LOCUS       NZ_JACHJK010000008     21038 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Streptomyces echinatus strain CECT 3313 Ga0436950_08, whole genome
            shotgun sequence.
ACCESSION   NZ_JACHJK010000008
VERSION     NZ_JACHJK010000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces echinatus
  ORGANISM  Streptomyces echinatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 445398)
  AUTHORS   Whitman,W.
  TITLE     Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the
            genomes of soil and plant-associated and newly described type
            strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 445398)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 160.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014203595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 05:39:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,466
            CDSs (total)                      :: 8,381
            Genes (coding)                    :: 8,094
            CDSs (with protein)               :: 8,094
            Genes (RNA)                       :: 85
            rRNAs                             :: 7, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 5, 1 (5S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 287
            CDSs (without protein)            :: 287
            Pseudo Genes (ambiguous residues) :: 0 of 287
            Pseudo Genes (frameshifted)       :: 116 of 287
            Pseudo Genes (incomplete)         :: 236 of 287
            Pseudo Genes (internal stop)      :: 12 of 287
            Pseudo Genes (multiple problems)  :: 77 of 287
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 227887
            Orig. end                         :: 248925
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACHJK010000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21038
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21038
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21038
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11038](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11038
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(342..1658)
                     /gene="aroA"
                     /locus_tag="FHS34_RS23270"
                     /old_locus_tag="FHS34_004719"
     CDS             complement(342..1658)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674885.1"
                     /locus_tag="FHS34_RS23270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004719"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_184968510.1"
                     /transl_table=11
                     /translation="MAPNSSSTALWPAPHASGAVDATVHVPGSKSVTNRALVLAALASE
                     PGWLRRPLRSRDTLLMAGALRAMGVEIEEGVGPDGTGEAWRVLPTGLRGPATVDVGNAG
                     TVMRFLPPVAALADGPIRFDGDPRSYERPLDGVIDALRVLGARIDDDGRGALPLTVQGG
                     GALDGGPVSVDASSSSQFVSALLLSGPRFNQGVEVRHTGASLPSLPHIRMTVDMLRAVG
                     AQVDTPESGGEPNVWRVTPGALLGRDLTIEPDLSNAQPFLAAALITGGKVLIPDWPSRT
                     TQPGDRLREIFTEMGGSCELTEYGLRFTGSGAIHGIDVDLGDVGELTPGVAAVAALADS
                     PSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRPLHGGTFHTYEDHRM
                     ATAGAIIGLAVEGVQIENVATTAKTLPDFPELWTGMLGQ"
     gene            complement(1687..2409)
                     /locus_tag="FHS34_RS23275"
                     /old_locus_tag="FHS34_004720"
     CDS             complement(1687..2409)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674886.1"
                     /locus_tag="FHS34_RS23275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004720"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_184968512.1"
                     /transl_table=11
                     /translation="MDSLAATALPDLWDRLTGSQPDPDLWVVLATAAAALAVVVPHPLW
                     RISRNAITIAHEGGHGLTALLTGRQLTGIRLHSDTSGLTVSRGKPYGLGMILTAAAGYT
                     APSLLGLGGAALLAAGRITLLLWVATALLVVMLVMIRNAYGVLTVVLAGGAFLLVSWLT
                     GPQVQAAFAYAVVWFLLLGGVRPPFELQAKRSRGGAGDSDADQLSRLTHVPAGLWLFLF
                     HAVSLCSLIGGGRWLLEG"
     gene            2460..3275
                     /locus_tag="FHS34_RS23280"
                     /old_locus_tag="FHS34_004721"
     CDS             2460..3275
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="FHS34_RS23280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004721"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_184968514.1"
                     /transl_table=11
                     /translation="MCGRYASSRGPEDLAGIFEIEKWEPEETLEPDYNVAPTKEVYAVL
                     DRPLKDADSPRPVRQLRKLKWGLVPSWAKTPEGGARMINARAETVHEKPSYRRAFAARR
                     CIVPADGYYEWVTGEQERDLEVEGKKKRPRKQPYFVLPADGSVFAMAGLYEFWRDRTLP
                     DDHPRAWWVTCSVITTEAERTPLAVAPAEGPHTLADIHPRMPLMLTPDRWDAWLDPSRT
                     DPDGLRDLLTPPPAGLMRAYPVPTAVSNVRNNGPELLKELEAPEEGTLF"
     gene            3277..3906
                     /locus_tag="FHS34_RS23285"
                     /old_locus_tag="FHS34_004722"
     CDS             3277..3906
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998051.1"
                     /locus_tag="FHS34_RS23285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004722"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_184968516.1"
                     /transl_table=11
                     /translation="MTTETVATDAGDARITWHEAKRARLVLAVGHGAGGGIEARDLQAL
                     AGTLPGHGVTVALVEQPWRVAGKKVAPAPKTLDTGWRGVWPALAKPGLPVISGGRSAGA
                     RVACRTAAELGAHAVLALSFPLHPPGRPEKSRAQELLGAGVPTLVVQGGNDPFGRPEEF
                     PDGSYELIEVPYGDHGFAVPKRAGTTQERALEIITDGVAGWVAALG"
     gene            4164..4859
                     /gene="sigR"
                     /locus_tag="FHS34_RS23290"
                     /old_locus_tag="FHS34_004723"
     CDS             4164..4859
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="FHS34_RS23290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004723"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_225817570.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTDNGQAEQPEGQGVSAETSGETTAERSRRFERDAL
                     EFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINS
                     YRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEF
                     RIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGE
                     SNEAKGSGS"
     gene            4856..5167
                     /gene="rsrA"
                     /locus_tag="FHS34_RS23295"
                     /old_locus_tag="FHS34_004724"
     CDS             4856..5167
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136687.1"
                     /locus_tag="FHS34_RS23295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004724"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_184968520.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCGEVLDHLYEFLDSEMPDVDRDKFQHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGHDDVPADLRAKVMGRIDLIRSGQTVPEHDVTKAPTAPQES"
     gene            5279..6583
                     /locus_tag="FHS34_RS23300"
                     /old_locus_tag="FHS34_004725"
     CDS             5279..6583
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674892.1"
                     /locus_tag="FHS34_RS23300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004725"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_184968522.1"
                     /transl_table=11
                     /translation="MEAVPARARGYVTGVALLAALSLSRLPATPTPWAATLLLAALYAT
                     CEHVVHRRFGGPFYPVLLAGAFLLPPAAAALVPVPAALLSPVEHRPALPRRVWRAAQPA
                     LAVWAAARVHGALGGRDAVVRSDFPHALLPAGAAVLAFCLVLTALDGGLRAAAGPVPLR
                     RAWRGLLARSLAAVAVHGLAGLMMAVLWRSPYGPVSALLVLLPMCVSWWVFAQYHRERA
                     AHQATIRALVQAVDIKDGYTRGHSERVGQASVLIARELGMDDDRVEVLRFAGILHDVGK
                     LGVPTRLLRKDGPLTPQERRIIELHPEYGHEMVRGISFLGEARAAILHHHERLDGTGYP
                     YGLAGAQIPECARIVAVADAFDAMTSTRSYSRARPVEAAVAELERCAGAHFDPRMVTAL
                     VRALARSGWHPAVTADEPAYGTPPAQRASRTGVPR"
     gene            6580..7860
                     /locus_tag="FHS34_RS23305"
                     /old_locus_tag="FHS34_004726"
     CDS             6580..7860
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674893.1"
                     /locus_tag="FHS34_RS23305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004726"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_184968524.1"
                     /transl_table=11
                     /translation="MTVLRLVHGAAALVSAASLAVTLWTGLADRGDALAFGVLIAVGEL
                     TRWSDTRARQAAPLGAAGSLSYALLGADAGRPSQHDAAQVVTVVLVAALIGAVPHIWAG
                     RTATADHLARRVLTVGFAAVCFQPLYNRGVFDSWSGPAYALLLLTLLALTSLCGAVLAA
                     ALAHCRTGWPFGPLLREELRGLLGIGSAVVATGAVIALAVAVVGLWALPVFCLPMLLVQ
                     LSVRRYAAVRATYRQTIASLARATEIAGCTPAGHARRVAALSLAVGRDLGLTGPELTVL
                     EYAALMHDIGQLSLVDPVPAGATAALPAAEQRRIALLGGAVVRQTGVDAAVAVVVERQA
                     DPYPEQPLAARIVRAVNAYEEKTREAGPEGPLRALEELRLGTAGDYAPEVVESLARVLA
                     QPQGARERVPVRRTGLSDPEPGWVTHG"
     gene            7961..8941
                     /locus_tag="FHS34_RS23310"
                     /old_locus_tag="FHS34_004727"
     CDS             7961..8941
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="FHS34_RS23310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004727"
                     /product="hypothetical protein"
                     /protein_id="WP_184968526.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGELLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRETGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGGAAAAAEPLGMELGSAAVRLSPEGEAEVVWGRRLDPARLEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTSAGHSYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGEGVHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGVAAPASLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            9015..9665
                     /gene="def"
                     /locus_tag="FHS34_RS23315"
                     /old_locus_tag="FHS34_004728"
     CDS             9015..9665
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="FHS34_RS23315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004728"
                     /product="peptide deformylase"
                     /protein_id="WP_184968528.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDEGYVVDTGECEERESAWRERGTSRPIT
                     VVGNPVLHKECRDVTEFGEELQQLVADMFASQRTAEGVGLAANQIGVDSKVFVYDCQDD
                     EGVRHVGVVCNPKLVDLPAERRRLDDSNEGCLSVPTAYASLARPDYAEVTGQDEKGNPV
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMAENEPRYPVVAND"
     misc_feature    complement(9809..9826)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            10001..11038
                     /gene="cyc1"
                     /locus_tag="FHS34_RS23320"
                     /old_locus_tag="FHS34_004729"
     CDS             10001..11038
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980387.1"
                     /locus_tag="FHS34_RS23320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004729"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_184968926.1"
                     /sec_met_domain="T1TS (E-value: 5.9e-61, bitscore: 201.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSLALPVIESAFPRQLHPYWPRLQEKTRLWLLEKRLMPATKVA
                     EYADGLCYTDLMAGYYTGAPDEVLQAIADYSAWFFIWDDRHDRDVVHGRAGHWRRLRYR
                     LHAALDAPRHHLHHPDPLVASFADSVLRLYGFLPRTWNQRFARHFHAVIEAYDREFRNR
                     TEGYIPGVEEYLALRRHTFAHWIWTDLLEASAGRELPGAVRKNPAYRRAALLSQEFAAW
                     YNDLCSLPKEIAGDEVHNLGISLITHEGLTLEETVDEVRRRIEECIEEFLVVEKNALRF
                     ADEIDDGTVRGKELSAAVRSCVGNMRNWFSSVYWFHHESGRYMVDSWDDRSTPPYVTNE
                     AAGEK"
     gene            11035..12423
                     /locus_tag="FHS34_RS23325"
                     /old_locus_tag="FHS34_004730"
     CDS             11035..12423
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674897.1"
                     /locus_tag="FHS34_RS23325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004730"
                     /product="cytochrome P450"
                     /protein_id="WP_184968531.1"
                     /sec_met_domain="p450 (E-value: 5.1e-68, bitscore: 224.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLESVKPEAPGTRDTSEAPELRLPPLAGGAVPVLGHGLKLVRDP
                     LAFMSALREHGDIVRLRLGPKTVYAVTTPALTGALALSPDFKIDGPLWESLEGLLGKEG
                     VATANGPRHRRQRRTIQPAFRLDAIPDYGPVMEEEAHALTGRWKPGETIDCTSESFRVA
                     VRIAARCLLRGDCMDERAERLSIDLAAVFRGMYRRMVMPLGPLYRLPFPANREFNRALA
                     DLHLLVDEIVAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETVA
                     STIMWLLQVLAEHPEHAEKVRTEVESVTGGRPVGFEHVRALRHTNNVVVEAMRLRPAVW
                     ILTRRAVTDTELGGYRIPAGADIVYSPYAIQRDGRSYARHLDFDPDRWLPERAKDVPKY
                     AMSPFSVGNRKCPSDHFSMTQLSLITAAISAKYRFEQVDGSNDSTRVGITLRPHDLRLR
                     AMPW"
     misc_feature    11104..11106
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12446..13408)
                     /locus_tag="FHS34_RS23330"
                     /old_locus_tag="FHS34_004731"
     CDS             complement(12446..13408)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018544423.1"
                     /locus_tag="FHS34_RS23330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004731"
                     /product="GlxA family transcriptional regulator"
                     /protein_id="WP_184968533.1"
                     /transl_table=11
                     /translation="MLKNVAAVLLDGVHPFELGVVCEVFGIDRSDDGLPVYDFAVVSAE
                     GPELRTHCGFGVTTPYGLERLEEADLIAVPAGETYAQREYPAELLAALRRAVDRGTRVL
                     SVCSGVFVLAAAGLLDGRRCAVHWHHAEQLARRYPRLTVEPDVLYVDEDPVITSAGTAA
                     GIDACLHLVRKEQGPEVANKIARRMVVPPHRDGGQAQFIERPLPKAPCDTVGEVLAWME
                     SHLDQEVTVEQLAARAHMAPRTFARRFQQETGTTPYRWILRQRVLLAQELLEGTDETMD
                     AIAWRTGFGTAAALRHQFVRALGTTPNAYRRAFRGPQAA"
     gene            13502..13717
                     /locus_tag="FHS34_RS23335"
                     /old_locus_tag="FHS34_004732"
     CDS             13502..13717
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674899.1"
                     /locus_tag="FHS34_RS23335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004732"
                     /product="hypothetical protein"
                     /protein_id="WP_221509315.1"
                     /transl_table=11
                     /translation="MNGNQIEGLIGILATLGILVLLILPSALGAVRDRRVDRQLREAER
                     PATPPRAGAKEEPERLGRRSGVARHA"
     gene            complement(13797..14810)
                     /locus_tag="FHS34_RS23340"
                     /old_locus_tag="FHS34_004733"
     CDS             complement(13797..14810)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674901.1"
                     /locus_tag="FHS34_RS23340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004733"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_184968537.1"
                     /transl_table=11
                     /translation="MTTRNTNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLH
                     SDVADLARLTPEEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEE
                     AVHVQFYLTLLDTYLPDPDDRAAAFDAVENIPSIREKAGFCFKWINEVEKIDRLETKAD
                     RRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFD
                     VVDTVRKEEPELFDDELQQQVTDMLREAVEAELQFARDLCGDGLPGMNTDSMRQYLECV
                     ADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(14810..17167)
                     /locus_tag="FHS34_RS23345"
                     /old_locus_tag="FHS34_004734"
     CDS             complement(14810..17167)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674902.1"
                     /locus_tag="FHS34_RS23345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004734"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_184968539.1"
                     /transl_table=11
                     /translation="MTIAPADPASVTELETDGPGTALLRTLTELTVDLPDADPGRVAAA
                     ALRGRSARADEAELRELATEASAGLISEDPVYSKLAARLLTLAIRDEAASQGVTSFTGS
                     IAVGHREGLIADRTAEFVRIHAERLDALVDVAADDRFGYFGLRTLHSRYLLRHPITRKV
                     VETPQHFMLRVASGLAEDDTTRSVDEVAALYGLMSRLDYLPSSPTLFNSGTRHPQMSSC
                     YLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVPFLK
                     TLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWIPDE
                     FMRRVNADEQWSLFSPADVPELVDLWGEEFDAAYRGAEAAGLAKKTMPARELYGRMMRT
                     LAQTGNGWMTFKDAANRTANQTAEAGNVIHSSNLCTEILEVTDDGETAVCNLGSVNLGA
                     FVSDGDIDWDRLDETVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGAMGLQDVFF
                     KLRLPFDSAEAKALSTRIAERIMLAAYEASADLAERNGPLPAWDQTRAARGVLHPDHYG
                     VEPAWPERWDALRTRIAETGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLS
                     GEFLQVNSYLVQDLKNLGVWDARTREALRDANGSVQDFVWIPEDVRDLYRTAWEIPQRG
                     LIDMAAARTPYLDQAQSLNLFLETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATRIARA
                     AQAQATIPVQQVTDPDAVACSLENPESCEACQ"
     regulatory      complement(17291..17422)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17412..17426)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.4"
                     /tool="antismash"
     misc_feature    complement(17443..17457)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(17468..17974)
                     /locus_tag="FHS34_RS23350"
                     /old_locus_tag="FHS34_004735"
     CDS             complement(17468..17974)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326961.1"
                     /locus_tag="FHS34_RS23350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004735"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_184968542.1"
                     /transl_table=11
                     /translation="MDFLIRRAGPEEYGALGEITAQAYLRDGLLAFDEDDWYLGELRDV
                     AGRAAAAEVLVAVRDAGLLGGVTFVPSGGPMTDIAGPGEAEIRMLAVDHAARGQGVGEA
                     LVRACVERARAVEGCAGVVLSTQRTMRTAHRIYERLGFERAPERDWNPLPGRSDLTLLT
                     YALTL"
     gene            complement(18049..19677)
                     /gene="mctP"
                     /locus_tag="FHS34_RS23355"
                     /old_locus_tag="FHS34_004736"
     CDS             complement(18049..19677)
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006848 - pyruvate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mctP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="FHS34_RS23355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004736"
                     /product="monocarboxylate uptake permease MctP"
                     /protein_id="WP_184968544.1"
                     /transl_table=11
                     /translation="MKDGVNGVALGVFIFFFLAVTVMGFLAARWRKAENEQSLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHRHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     ENTNWFVKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDALIYIVIAVAIIYIPIKLGG
                     FDDVFAKAGDAFAQVNPATGKPRGALVPAEAGQWTYATLALGSALALFMYPHSITATLS
                     SRSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGVKVTNGQLAIPQLFEDMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATAAEETRVSKIVSLLVKVGAL
                     VFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMVYGTVAAY
                     GVASPTQKHFGGSAKEIPGIGEIGYIGLTAFVINVVVTVVLTFVLKALKAPEGLDETRP
                     EDYTADAGDPGVQAELPSATAGAGH"
     gene            complement(19674..19937)
                     /locus_tag="FHS34_RS23360"
                     /old_locus_tag="FHS34_004737"
     CDS             complement(19674..19937)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437917.1"
                     /locus_tag="FHS34_RS23360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004737"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_184968546.1"
                     /transl_table=11
                     /translation="MSETPEVRPPVVTPARVIIAVCLVAPFVAMLWVGSYAKTDPAFIG
                     IPFFYWYQMLWVLISTALTMLAYQLWKRDQRAREDANGGAVK"
     misc_feature    complement(19988..20003)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    complement(20006..20020)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     gene            complement(20059..20820)
                     /locus_tag="FHS34_RS23365"
                     /old_locus_tag="FHS34_004738"
     CDS             complement(20059..20820)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="FHS34_RS23365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_004738"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_184968548.1"
                     /transl_table=11
                     /translation="MTTDVSSAENEAGTTRTARVPKYYRLKKHLLDMTETQAPGTPVPP
                     ERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQ
                     GLEPTSQLLDIGYVTADDRLAELLDITAGGRVLRIERLRMANGEPMAIETTHLSAKRFP
                     ALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHS
                     LDREGKPVEWVRSVYRGDRYKFVARLKRPAE"
     misc_feature    20956..20971
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.44"
                     /tool="antismash"
ORIGIN
        1 gatcgtcgtc gtcggccgtg cggcgcagca gcgacgaccg ctcctcgatg cggacgatcc
       61 gcgcgagcgt gtccttcatg ccggacagat cgccgaccag ggccacccgg tcgcccacca
      121 cggccgcctt gcggcccagc tcgcgggcct tcatcgccat gatcgtgcgg tcgtcgacca
      181 gacaggtcag ccggccccgg tcgacggtga ggaccatccc ctccgccgcg tcctcgtgct
      241 tcgggcggat gttcgtccgc ggccggttgc ccttgcggtt gggacggctg cggatgtcgt
      301 cctcgtcggt gtgcttgccg tagcggcgca tggcgtgatc cctactgtcc gagcattccg
      361 gtccacagct cggggaagtc cggcagggtc ttcgccgtcg tcgccacgtt ctcgatctgc
      421 acgccctcga ccgccaggcc gatgatcgca ccggcggtcg ccatgcggtg gtcctcgtag
      481 gtgtggaagg tcccgccgtg cagcgggcgc ggacggatgt ggaggccgtc ggccgtctcc
      541 gtgacgtcac cgcccagctc gttgatctcc ttggtgagcg cggccagccg gtccgtctcg
      601 tgcagccgca gatgcgccac gccccgcagg gtggacggcg agtcggcgag cgcggccacg
      661 gccgcgacgc ccggggtcag ctcgcccacg tcgcccaggt ccacatcgat gccgtggatc
      721 gcacccgaac cggtgaaccg cagcccgtac tcggtgagct cgcaggaacc gcccatctcg
      781 gtgaagatct cccgcagccg gtcacccggc tgggtggtgc gggacggcca gtccgggatc
      841 agcaccttgc cgccggtgat cagggccgcc gccaggaacg gctgtgcgtt ggacaggtcc
      901 ggctcgatcg tcaggtcccg gccgagcagc gcgcccggcg tcacccgcca cacgttcggc
      961 tcgccgcccg actcgggggt gtccacctgg gcgccgaccg cacgcagcat gtccaccgtc
     1021 atccggatgt gcggcagcga gggcaggctc gccccggtgt gccggacctc cacgccctgg
     1081 ttgaagcgcg ggccggacag cagcagtgcc gagacgaact gggacgacga ggaggcgtcg
     1141 accgagaccg gaccgccgtc cagcgccccg ccgccctgca cggtcagcgg cagcgcgccc
     1201 cggccgtcgt cgtcgatccg ggcaccgagc acccgcagcg cgtcgatcac gccgtcgagg
     1261 ggacgctcgt acgaccgcgg gtccccgtcg aaccggatgg gaccgtcggc cagcgcggcc
     1321 accggcggca ggaaccgcat cacggtgccc gcgttgccga cgtcgaccgt ggccgggccg
     1381 cgcaggcccg tgggcagcac ccgccaggcc tcgccggtgc cgtcggggcc gacgccctcc
     1441 tcgatctcca cgcccatggc cctgagggcg ccggccatca gcagggtgtc ccgggaccgc
     1501 agcgggcggc gcagccagcc cggctcggag gcgagggcgg cgaggaccag ggcacggttg
     1561 gtgaccgact tggaccccgg cacgtggacc gtcgcgtcga cggccccgct cgcgtgcggg
     1621 gcgggccaga gtgcggtgga ggagctgttc ggggccatgg ggccacttta taaggagggc
     1681 ccggggtcaa ccttccagca gccagcggcc cccgccgatc agcgagcaca gggacaccgc
     1741 gtggaacagg aacagccaca ggcccgccgg tacgtgcgtc agccgcgaca gctggtccgc
     1801 gtccgagtcc ccggcccctc cccgggaccg cttggcctgc agttcgaacg gcggccggac
     1861 cccgccgagc agcaggaacc acaccaccgc gtacgcgaac gccgcctgca cctgcggtcc
     1921 cgtcagccag gacaccagca ggaacgcccc gcccgcgagg accacggtca gtacgccgta
     1981 cgcgttgcgg atcatcacca gcatcaccac cagcagggcg gtggccaccc acagcagcag
     2041 agtgatgcgg ccggcggcca gcagcgcggc cccgccgaga cccagcagcg agggagccgt
     2101 gtaccccgcc gcggccgtga ggatcatccc caggccgtac ggcttgcccc ggctgaccgt
     2161 gagcccgctg gtgtcggagt gcagccggat gccggtgagc tgccggccgg tgagcagggc
     2221 ggtcaggccg tggccgccct cgtgggcgat ggtgatcgcg ttgcgggata tccgccacag
     2281 cggatggggc acgaccacgg cgagcgccgc ggccgcggtg gccagcacca cccacaggtc
     2341 gggatcgggc tgggagccgg tgagccggtc ccagaggtcg ggcagcgcgg tggcggcgag
     2401 gctgtccata tctcgcggtg gctccctgca gtagtacgga gtctggcagt gtggcacgta
     2461 tgtgcggacg gtatgcatcg agtcgtgggc ccgaggatct cgcgggtatc ttcgagatcg
     2521 agaagtggga gcccgaagag accctggagc cggactacaa cgtggctccg accaaggagg
     2581 tctacgccgt cctggaccgc cccctgaaag acgcggactc cccgcgtccg gttcgccagc
     2641 tgcggaagct gaagtggggc ctggtcccgt cctgggccaa gacgcccgag ggcggcgccc
     2701 gcatgatcaa cgcgcgcgcc gagaccgtgc acgagaagcc ctcctaccga cgggccttcg
     2761 ccgcccgccg ctgcatcgtg ccggccgacg gctactacga gtgggtcacc ggcgagcagg
     2821 agcgcgatct ggaggtcgag ggcaagaaga agcggccgcg caagcagccg tacttcgtgc
     2881 tgcccgccga cggctcggtg ttcgcgatgg ccggcctgta cgagttctgg cgcgaccgga
     2941 ccctgcccga cgaccacccc cgggcctggt gggtcacctg ctcggtgatc accaccgagg
     3001 cggagcggac cccgctggcg gtggccccgg ccgagggccc gcacaccctc gccgacatcc
     3061 acccccggat gccgctgatg ctcaccccgg accgctggga cgcctggctc gacccgtccc
     3121 gcaccgaccc cgacggcctg cgcgacctgc tcacgccgcc gcccgccggc ctgatgcgcg
     3181 cctatccggt ccccaccgcc gtcagcaacg tccgcaacaa cggccccgag ctgctgaagg
     3241 agctggaggc accggaagag ggcacactct tctgacgtga ctaccgagac cgttgccacg
     3301 gatgcgggag atgcccggat cacctggcac gaggcgaagc gtgcgcggct ggtgctggcc
     3361 gtcggccatg gggcgggcgg cggcatcgag gcgcgcgacc tccaggcact cgccgggacg
     3421 ctcccggggc acggcgtcac cgtcgccctc gtcgagcagc cctggcgggt cgccgggaag
     3481 aaggtcgcgc ccgccccgaa gacgctggac accgggtggc gcggcgtgtg gcccgccctc
     3541 gcgaagccgg gactgccggt gatctccggc ggccggagcg ccggggcgcg cgtcgcctgc
     3601 cgtacggcgg ccgagctggg cgcccacgcc gtgctcgccc tcagcttccc gctgcacccg
     3661 ccgggcaggc cggagaagtc ccgcgcgcag gagctgctgg gcgccggcgt gcccacgctg
     3721 gtcgtccagg gcgggaacga ccccttcggc aggccggagg agttccccga cggctcctac
     3781 gagctgatcg aggtgccgta cggcgatcac gggttcgccg tgcccaagcg tgccgggacc
     3841 acccaggagc gcgcgctgga gatcatcacc gacggggtcg cggggtgggt cgcggcgctc
     3901 gggtgacggc cgggaatgtt gcgcggccgc ccgctgttga ggcccacaga agtgctgagg
     3961 acctcggcac cgacgtcgtg ggagaggaag tccgccgcat gggttcgacc atctgcccga
     4021 gccgcagcag ccgcaccgac ctggactgga cggtgctgca cgcggccagg accgctccta
     4081 ttcgagcggc ggcgggtacg ggtcgtgttc tatcctccga atcgagtggg atcggttctg
     4141 gtcctgcccg ggatcttgag gaggtgggtc cggtcaccgg taccgacgca gggaccgaca
     4201 acggccaggc ggagcagccc gagggccagg gcgtcagcgc ggaaacgtcc ggtgagacga
     4261 ccgcggagcg cagccggcgc ttcgagcggg acgcgctcga attcctcgac cagatgtact
     4321 cggccgcgct gcgcatgacc cgcaacccgg ccgacgccga ggacctggtg caggagacgt
     4381 acgccaaggc gtacgcgtcc ttccaccagt tccgcgaggg caccaacctc aaggcgtggc
     4441 tgtaccggat cctcaccaac accttcatca actcgtaccg caagaagcag cgcgagcccc
     4501 agcgcagcgc ggccgaggag atcgaggact ggcagctcgc ccgcgccgag tcgcacatgt
     4561 cgacgggact gcgttccgcc gagtcgcagg cgctggacca cctgccggac tcggacgtga
     4621 aggaagcgct gcaggcgatc cccgaggagt tccgcatcgc cgtctatctc gcggacgtcg
     4681 agggctttgc gtacaaggag atcgcggaca tcatggggac acccatcggt acggtgatgt
     4741 cccggctgca ccggggccgc cggcaactgc gcggcatgct ggaggactac gcccgtgagc
     4801 gcgggctggt cccggcgggc gccggggagt cgaacgaagc gaaaggctcg ggctcatgag
     4861 ctgcggagag ccgcacgaga cggactgcgg tgaggtcctg gaccatctgt acgagttcct
     4921 cgacagcgag atgccggacg tcgaccgcga caagttccag caccacttcg aggaatgctc
     4981 gccgtgcctg gagaagtacg gcctggagca ggccgtgaag aagctggtga agcggtgctg
     5041 cggccatgac gacgtgcccg ccgacctgcg cgccaaggtc atggggcgga tcgatctgat
     5101 ccgctccggg cagaccgtgc cggaacacga cgtgaccaag gcgccgaccg cgccccagga
     5161 gtcctgacac gccggggcat atcacccgaa cgtgctaatc ctcaggtcat aagccccgca
     5221 ccccccgata accgccctag gctccgagcc tggacaggca tggtcgggga ggggcgtgat
     5281 ggaggcggta ccggcgaggg cgcgcggcta tgtgaccggt gtcgccctgc tcgccgcgct
     5341 cagcctgtcc cggctgccgg ccacccccac cccctgggcc gccacgctcc tgctcgccgc
     5401 gctctacgcc acctgcgagc acgtcgtgca ccgccgcttc ggcggcccct tctaccccgt
     5461 gctgctcgcc ggcgcgttcc tgctgccccc ggcggccgcc gcgctcgtcc cggtgcccgc
     5521 cgccctgctg tccccggtcg agcaccggcc cgccctgccg cgaagggtgt ggcgggccgc
     5581 gcagcccgcg ctcgccgtgt gggccgccgc ccgggtgcac ggggcgctcg gcggccggga
     5641 cgccgtcgtc cgctccgact tcccccacgc cctgctgccc gccggcgcgg ccgtcctcgc
     5701 cttctgcctg gtgctcaccg cgctcgacgg cggcctgcgc gcggcggccg ggccggtgcc
     5761 gctgcgccgg gcctggcgcg gcctgctggc ccgctccctc gccgccgtcg cggtgcacgg
     5821 cctcgccgga ctgatgatgg ccgtgctgtg gcgcagcccc tacggccccg tgtccgcgct
     5881 gctcgtgctg ctgccgatgt gcgtctcctg gtgggtgttc gcccagtacc accgcgaacg
     5941 cgcggcccac caggccacca tccgcgccct cgtccaggcc gtcgacatca aggacggcta
     6001 cacgcgcggc cacagcgaac gggtcggaca ggcatctgtg ctgatcgccc gcgaactcgg
     6061 catggacgac gaccgtgtcg aggtgctccg cttcgccggc atcctgcacg acgtcggcaa
     6121 gctgggcgtg cccacccggc tgctgcgcaa ggacgggccg ctcactcccc aggagcggcg
     6181 gatcatcgaa ctgcatcccg agtacggcca cgagatggtc cgcgggatct ccttcctcgg
     6241 cgaggcccgc gcggccatcc tccaccacca cgagcggctc gacggcaccg gctacccgta
     6301 cgggctggcc ggcgcccaga tccccgagtg cgcccggatc gtcgccgtcg cggacgcctt
     6361 cgacgccatg acctccaccc gctcctacag cagggcccgc ccggtcgagg cggccgtcgc
     6421 cgagctggag cgctgcgccg gggcccactt cgacccccgc atggtcaccg cgctcgtccg
     6481 cgccctggcc cgctccggct ggcacccggc ggtcaccgcc gacgaaccgg cgtacggcac
     6541 cccgcccgcg cagcgggcct cccgcaccgg ggtgccccga tgaccgtcct gagactcgtc
     6601 cacggcgccg ccgccctcgt ctcggccgcc tccctcgccg tcaccctgtg gaccggcctg
     6661 gccgaccggg gcgacgcgct cgccttcggc gtgctcatag ccgtcggcga gctgacccgg
     6721 tggagcgaca cccgggcacg ccaggccgca ccgctcggcg ccgccggctc cctgtcgtac
     6781 gcactgctgg gcgccgacgc cggccggcca agccagcacg acgccgccca ggtcgtcacc
     6841 gtcgtcctgg tcgccgccct gatcggcgcc gtcccgcaca tctgggccgg ccgcaccgcc
     6901 accgccgacc acctggcccg ccgcgtcctc accgtcgggt tcgccgccgt ctgcttccaa
     6961 cccctgtaca accggggcgt cttcgactcc tggagcggcc ccgcctacgc cctgctgctg
     7021 ctcaccctgc tcgcgctcac ctcgctgtgc ggcgcggtcc tggccgccgc gctggcccac
     7081 tgccgcaccg gctggccgtt cggaccgctg ctgcgcgaag aactgcgcgg gctgctcggc
     7141 atcggctccg ccgtcgtcgc gaccggcgcg gtgatagcgc tcgcggtcgc cgtcgtcgga
     7201 ctgtgggcgc tgcccgtgtt ctgcctgccc atgctgctcg tccagctgtc cgtgcgccgg
     7261 tacgcggccg tgcgtgccac ctaccggcag accatcgcct ccctcgcccg cgccacggag
     7321 atcgccggct gcacccccgc cgggcacgcc cgccgcgtcg ccgcgctcag cctcgccgtc
     7381 ggccgggacc tcggcctgac cggcccggaa ctgaccgtcc tggagtacgc ggccctgatg
     7441 cacgacatcg gacagctcag cctggtcgac ccggtcccgg ccggcgccac cgccgccctg
     7501 ccggccgcgg agcagcggcg tatcgccctg ctcggcggcg ccgtcgtccg gcagaccggg
     7561 gtcgacgccg ccgtcgccgt cgtcgtggag cgacaggccg acccctaccc ggaacagccc
     7621 ctcgccgccc gcatcgtccg ggccgtgaac gcctacgagg agaagacccg ggaggccggc
     7681 cccgagggcc cgctccgtgc gctggaggag ctgcgactgg gcaccgccgg ggactacgct
     7741 cccgaggtcg tggagtcgct cgcccgggtg ctggcccagc cccagggcgc gcgggagcgc
     7801 gtcccggtga gacgaacggg actgtctgac cccgagcccg gctgggtaac ccatgggtaa
     7861 tgagcgcctt tcccgtcgta cgtggttgga tgcgagggag agggtgtccg ggggcacaag
     7921 ccagcccact gtgcggaact ggaactggca ggcgggaatc gtgaggatct tcggcaaggg
     7981 acggcaccgg ccctccgcct cctggcggca ggcgaccgac cgggcgttca cgctcatcgg
     8041 ggacggccgg tacgaggacg ccggcgagct gctgacacgc gccgccgacc tggagccctg
     8101 gctgtcggag tcctggttca acctcgccct gctgcacaag ttccggcacg actgggagca
     8161 ggcccgcgcg gccggactgc gtgcggtggc cctgctcgac cgggagaccg gggcgcccga
     8221 ctggtggaac gtgggcatcg ccgcgaccgc cctgcaggac tggccgctgg cccgccgcgc
     8281 ctggcaggcg tacgggctga aggtgcccgg gggtgccgcg gccgccgccg agccgctcgg
     8341 catggagctg ggcagcgccg ccgtacggct ctccccggag ggcgaggccg aggtcgtctg
     8401 gggccgccgg ctggacccgg cccggctgga ggtgctctcc atcccgctcc cctcgtccgg
     8461 gcggcgctgg ggcgaggtcg tgctgcacga cggcgtcccg cacggcgagc gcaccacgtc
     8521 cgcggggcac tcctacccgg tcttcgacga gatcgagctg tgggcgccgt cccccgtgcc
     8581 cacctgggtg gtcctgctgg aggcggccac cgaggcggac cgggacgcgc tggagcagct
     8641 cgcggccgac gccgggttcg ccgcggagga ctggtcgtcg tcggtgcggc tgctgtgccg
     8701 gatgtgctcc gagtcacgga tgccgtccga cgagggcgag ggcgtgcacc tcgacccgca
     8761 cgatcacagc gagccggggc atccggggcc gctggggcac cggacggacg ggcagctgtg
     8821 ggtgccggag cgggagtgcg gggtggccgc gccggcctcg ctggtgcggg ggctgctgga
     8881 cggctgggtg gccgacagcc cggactccag ggactggcgg gatctggaag aggtttgctg
     8941 agccgccggt gagcagccgc ctttaggctg tactcgcaga attttccagg cttgcaggaa
     9001 ggcgtacgtc ggtcatggcg cagcaggaca ccgatcagca gcacgcgggc gtgctccccg
     9061 tcgacgacga gggctatgtc gtcgacacgg gggagtgcga ggagcgcgag agcgcctggc
     9121 gtgagcgcgg cacctcgcgg ccgatcacgg tcgtcggcaa tccggtgctg cacaaggagt
     9181 gcagggacgt caccgagttc ggcgaggagc tgcagcagct ggtcgccgac atgttcgcca
     9241 gccagcgcac cgccgagggc gtgggcctgg ccgccaacca gatcggtgtc gactcgaagg
     9301 tcttcgtcta cgactgtcag gacgacgagg gcgtccggca cgtcggcgtg gtgtgcaacc
     9361 cgaagctggt cgacctgccc gccgagcggc gccggctcga cgacagcaac gagggctgcc
     9421 tgtccgtgcc cacggcgtac gcgtcgctgg cccggccgga ctacgccgag gtgaccggcc
     9481 aggacgagaa gggcaacccg gtcaaggtcc ggggcaccgg ctacttcgct cggtgtttgc
     9541 agcacgagac cgaccacctc tacggctacc tgtacatcga ccggctgtcg aagcgggacc
     9601 gcaaggacgc gctgcggcag atggccgaga acgagccacg ctaccccgtg gtcgccaacg
     9661 actgaccagg gcagggcact tggggcgccc ggccgggatc cttcccggcc gggcgccttc
     9721 gtgttgccgc ggttcgctca tgcgtgcgtc gtacaaccga tccaatgtgc gctcctagtg
     9781 atccttaatc agtcacacaa ggggggattc tcggcaccat ggggtagtga gtgaagcaaa
     9841 tccgttccca cgccggtcag ttgtggtgct gaatgtaaga gcggggatac gcaacggcgc
     9901 acgcccggca cgggaggggt gcgcgctcct ggcggctgag aggggtttgt acgtgcaagc
     9961 tttcccacgc agcaccacag cgacggcgac ggcggtcgta gtgccaccct cactggcact
    10021 cccggtgatc gaatccgcct ttccgcggca actgcacccg tattggcccc ggctccagga
    10081 gaagacacgg ctctggctcc tggaaaagcg gctcatgccg gcgaccaagg tagcggaata
    10141 tgccgatgga ctgtgctaca cggacctcat ggcgggctac tacacagggg ctccggacga
    10201 ggtcctgcag gccatagccg actacagcgc ctggttcttc atctgggacg accgccacga
    10261 ccgcgacgtc gtgcacggcc gggcgggcca ctggcggcgg ctgaggtacc ggctgcacgc
    10321 cgccctcgac gcccccagac accatctgca ccatcccgac ccgctggtgg ccagcttcgc
    10381 ggacagtgtg ctgcggctgt acgggttcct gccgcgcacc tggaaccagc ggttcgcccg
    10441 gcacttccac gcggtgatcg aggcctacga ccgcgaattc cgcaaccgca ccgaaggata
    10501 catacccggc gtcgaggagt acctcgccct gcgccgccac accttcgccc actggatatg
    10561 gacggatctg ctggaagcga gtgcgggccg tgaactcccg ggcgccgtgc ggaaaaaccc
    10621 ggcgtatcgc cgggcggccc tcctcagtca ggagttcgcc gcctggtaca acgacctctg
    10681 ctcactgccg aaagaaatag cgggcgatga ggtgcacaat ctcggaatca gtctcatcac
    10741 ccatgaggga ctgaccctgg aagaaacggt ggacgaagtc aggcgacgca tcgaggagtg
    10801 catcgaggaa ttcctcgtgg tggagaagaa cgccctgcgg ttcgccgatg aaatcgacga
    10861 cggaacggtg cgcggcaagg aattgagtgc cgccgtccgg tcctgtgtcg ggaatatgcg
    10921 caactggttc agctccgtct actggttcca ccacgagtcc ggccggtaca tggtcgacag
    10981 ctgggacgac cggtccacgc ccccgtacgt cacgaacgaa gcggcaggtg agaaatgacc
    11041 cttgagtcgg tcaagcccga ggcccccggg acccgcgaca cctccgaggc gcccgagctg
    11101 cgcttaccgc ccctggccgg cggagccgta ccggtcctcg ggcacggcct gaaactggtc
    11161 cgcgacccgc tcgccttcat gtccgcgctg cgcgagcacg gtgacatcgt gcgtctgcgg
    11221 ctcggcccca agacggtgta cgccgtcacc acgcccgcgc tcaccggggc actggccctg
    11281 agccccgact tcaagatcga cggcccgctg tgggagtccc tcgaagggct cctcggcaag
    11341 gagggcgtgg ccaccgcgaa cggcccccgg caccgcaggc agcggcgcac catacagccc
    11401 gcgttccggc tcgacgcgat acccgactac ggcccggtca tggaggagga ggcgcacgcg
    11461 ctgaccggcc gctggaaacc cggcgagacc atcgactgca cctccgagtc cttccgggtc
    11521 gccgtccgga tcgccgcccg ctgcctgctg cgcggcgact gcatggacga gcgcgcggaa
    11581 cggctcagca tcgacctcgc cgccgtcttc cggggcatgt accgccggat ggtgatgccg
    11641 ctcgggccgc tctaccggct gccgttcccg gccaaccgcg aattcaaccg ggcattggcc
    11701 gatttgcatc tgctggtgga tgagatcgtc gccgagcgga gggcgtctgg tcaaaagccg
    11761 gacgatttgc tgacggcatt gctggaggcg aaggacgaca atggcgatcc catcggggaa
    11821 caggagatcc acgaccaggt cgtcgcgata ctcacccccg gcagcgaaac agtcgcgtcc
    11881 acgatcatgt ggctgcttca ggtcctcgcc gaacatccgg aacacgccga gaaggtacgg
    11941 accgaggtcg aatccgtgac cggtggccga ccggtcggat tcgagcacgt gcgcgcgctc
    12001 aggcacacca acaatgtcgt cgtcgaggcc atgcggctcc ggcccgccgt atggattctg
    12061 acgcggcgcg cggtgaccga caccgagctc ggcggctatc gcattccggc cggggcggac
    12121 atcgtctaca gcccgtacgc gatccagcgt gacggccgct cctacgcccg ccacctcgac
    12181 ttcgaccccg accgctggct gccggagcgg gccaaggacg taccgaagta cgccatgagc
    12241 ccgttcagcg tcggcaacag gaagtgtccc agcgaccact tctccatgac ccagctgagc
    12301 ctgatcaccg cggcgatctc ggcgaagtac cgcttcgagc aggtcgacgg gtcgaacgac
    12361 agcacccgcg tgggcatcac gctccgcccg cacgacctac gcctgcgggc gatgccctgg
    12421 tagggcgcct ggtaccggtg cgcgctcagg cggcctgcgg gccccggaac gcgcgccggt
    12481 aggcgttcgg ggtcgtcccg agggcccgga cgaactgatg gcgcagcgcg gcggcggtgc
    12541 cgaagccggt gcgccaggcg atcgcgtcca tcgtctcgtc cgtaccctcc agcaactcct
    12601 gtgccagcag aacccgttga cgaaggatcc accggtaggg agtggtcccc gtctcctgct
    12661 ggaagcgccg ggcgaaggtg cgcggcgcca tgtgggcgcg ggcggcgagc tgctccacgg
    12721 tgacctcctg gtcgagatgg ctctccatcc aggccagcac ctccccgacc gtgtcgcagg
    12781 gagccttcgg caggggccgc tcgatgaact gggcctgccc gccgtcccgg tgcggcggca
    12841 ccaccatccg gcgggcgatc ttgttggcga cttccgggcc ctgttccttg cgcaccaggt
    12901 gcagacaggc gtcgatcccg gcggcggtgc cggcggaggt gatgacggga tcctcgtcca
    12961 cgtacagcac gtccggctcg accgtgagcc gggggtagcg ccgggcgagc tgctcggcgt
    13021 ggtgccagtg caccgcgcag cgccgcccgt ccagcagtcc cgccgcggcc agcacgaaca
    13081 cgccggagca gacgctgagc acccgtgtgc cccggtcgac ggcccgccgc agcgccgcca
    13141 gcagctccgc cggatactcg cgctgcgcat aggtctcacc ggccggtacg gcgatcagat
    13201 cggcctcctc cagccgctcc aggccgtacg gggtggtcac gccgaacccg cagtgcgtgc
    13261 gcagctcggg gccctccgcc gacaccacgg cgaagtcgta cacgggcagt ccgtcgtcgc
    13321 tgcggtcgat gccgaacacc tcgcacacga cgcccagctc gaagggatgc actccgtcca
    13381 gcaggacggc ggccacgttc ttcagcatgc tgacagtgtg cctcgacagt ggcggtaatt
    13441 cgagggtgtg cggcagtcct gccgctcacg gtaaggagca ttcggcgcga cagtggtgtc
    13501 catgaacgga aaccagatcg aaggcctcat cggaatcctc gccaccctcg ggatcctggt
    13561 cctcctgatc ctcccgtccg cgctcggagc ggtgcgcgac cggcgcgtcg accgacagct
    13621 cagggaggcg gagcggcccg cgacgccccc gcgcgccgga gcgaaggaag agcccgagcg
    13681 cctcgggagg cgctccggcg tggcccggca cgcctgaccg gagaacgaac ggcgtcgccc
    13741 gtccgcaccc tcccgaaggc ggtgcggacg ggcgacgccg aacagcccgt ggccggtcag
    13801 aagtcctcgt ccaggtcgac cgtgccctcc acggcgacct ggtaggcgga gggacggcgc
    13861 tcgaagaagt tggtcagctc ctggacgccc tggagctcca tgaaggagaa ggggttctcc
    13921 gagccgtaca ccggggcgaa gccgagacgc gtcaggcgct ggtcggcgac gcattcgagg
    13981 tactggcgca tcgagtcggt gttcatgccg ggcaggccgt cgccgcagag gtcgcgggcg
    14041 aactgcagct cggcttcgac ggcctcccgc agcatgtcgg tgacctgctg ctggagctcg
    14101 tcgtcgaaga gctccggctc ctccttgcgg acggtgtcca ctacgtcgaa ggcgaaggac
    14161 atgtgcatcg tctcgtcgcg gaagacccag ttggtgccgg tggccaggcc gtgcaggagg
    14221 ccgcggctgc ggaaccagta gacgtaggcg aaggcgccgt agaagaacag tccctcgatg
    14281 caggcggcga agcagatgag gttgagcagg aagcggcggc ggtcggcctt ggtctccagc
    14341 cggtcgatct tctcgacctc gttgatccac ttgaagcaga acccggcctt ctcgcggatg
    14401 gaggggatgt tctccacggc gtcgaaggcg gcggcgcggt cgtccgggtc ggggaggtag
    14461 gtgtccagga gggtcagata gaactggacg tgtacggctt cctcgaacag ctgccggctc
    14521 aggtacagac gggcttcggg ggagttgatg tgcttgtaca gcgtcagcac gaggttgttg
    14581 gcgacgatcg agtcgccggt ggcgaagaag gccaccaggc ggccgatgag gtgctgttcc
    14641 tcgggcgtga gcctggcgag gtcggcgacg tcggagtgga ggtcgacctc ctcgacggtc
    14701 caggtgttct tgatggcgtc ccggtagcgc tcgtagaagt cggggtagcg catggggcgc
    14761 agggtcagtt cgaagcccgg gtcgaggagg ttggtgtttc gggtggtcat tactggcagg
    14821 cctcgcagga ctcggggttt tccagcgagc aggcgaccgc gtcggggtcg gtgacctgct
    14881 gcacggggat ggtggcctgc gcctgggcgg cgcgggcgat gcgcgtcgcc ggacgggagc
    14941 gcaggtagta cgtcgtcttc agcccggact tccaggcgta ggcgtacatg gaggagagct
    15001 tgccgatcgt cggcgtctcc aggaacaggt tgagggactg ggcctggtcc aggtacgggg
    15061 tgcgggcggc ggccatgtcg atgaggccgc gctgggggat ctcccaggcc gtgcggtaga
    15121 ggtcgcgtac gtcctccggg atccagacga agtcctggac ggagccgttg gcgtcgcgca
    15181 gggcctcgcg ggtgcgggcg tcccagacgc cgaggttctt caggtcctgc accaggtagg
    15241 agttgacctg gaggaactca ccggagaggg tctcgcgctt gaacaggttc gacacctgcg
    15301 gctcgatgca ctcgtacacc cccgcgatcg aggcgatggt ggccgtcggc gcgatcgcca
    15361 ggagcagcga gttgcgcatg cccgtctccg cgatgcgcgt gcgcagggcg tcccaccgct
    15421 cgggccaggc gggctcgacg ccgtagtggt cggggtggag gacgccgcgg gcggcgcggg
    15481 tctggtccca ggcgggcagc gggccgttgc gctcggcgag gtcggcggag gcctcgtagg
    15541 cggccagcat gatgcgctcg gcgatccggg tggacagggc cttggcctcg gcggagtcga
    15601 agggcaggcg cagcttgaag aagacgtcct gcaggcccat cgcgcccagt ccgaccggac
    15661 gccacttggc gttggagcgg cccgcctgct cggtggggta gaagttgatg tcgacgacgc
    15721 ggtcgaggaa ggtgacggcc gtacgcaccg tctcgtccag ccggtcccag tcgatgtcgc
    15781 cgtcggacac gaaggcgccg aggttgacgg agccgaggtt gcagacggcc gtctcgccgt
    15841 cgtcggtgac ctccaggatc tcggtgcaga ggttggagga gtggatgacg ttgccggcct
    15901 cggcggtctg gttggcggtg cggttggcgg cgtccttgaa ggtcatccag ccgttgccgg
    15961 tctgtgccag ggtgcgcatc atccggccgt acagctcgcg ggccggcatg gtcttcttcg
    16021 ccaggccggc ggcttcggcc ccgcggtagg cggcgtcgaa ctcctcgccc cacaggtcga
    16081 ccagctcggg cacgtcggcg ggggagaaca gcgaccactg ctcgtcggcg ttgacccggc
    16141 gcatgaactc gtccgggatc cagtgcgcca ggttgaggtt gtgggtgcgg cgggcgtcct
    16201 cgccggtgtt gtcccgcagc tccaggaact cctcgatgtc ggagtgccag gtctccaggt
    16261 agaccgcggc ggcgcccttg cgccggccgc cctggttcac cgcggcgacg gaggcgtcca
    16321 gggtcttcag gaacggcacg atgccgttgg agtgcccgtt cgtcccccgg atcagcgaac
    16381 cacggctgcg gatgcgggag tacgacagac cgatgccgcc ggcgtgcttc gacagccggg
    16441 cgacctggtg gtagcggtcg tagatggagt ccagctcgtc cagcggggag tcgagcaggt
    16501 agcaggacga catctgcggg tgtcgcgtgc ccgagttgaa cagggtgggg gaggacggca
    16561 gatagtccag gcggctcatc agcccgtaca gcgccgcgac ctcgtccacg gagcgcgtcg
    16621 tgtcgtcctc cgccagaccg ctcgccacgc gcagcatgaa gtgctggggc gtctcgacga
    16681 ccttgcgggt gatcgggtgg cgcagcaggt aacggctgtg cagggtgcgc aggccgaagt
    16741 agccgaaccg gtcgtcggcc gcgacgtcga ccagcgcgtc gagccgctcg gcgtggatcc
    16801 ggacgaactc cgcggtgcgg tcggcgatca ggccctcccg gtgcccgacc gcgatggacc
    16861 cggtgaacga cgtcacgccc tgcgaggcgg cctcgtcccg gatcgcgagg gtcagcagcc
    16921 gggccgccag cttcgagtag acggggtcct cggagatcag gccggcggag gcctccgtgg
    16981 ccagctcccg cagttccgcc tcgtcggccc gcgcggaccg gccacgcagc gcggcggcgg
    17041 cgacccgccc cgggtcggcg tcgggcagat cgacggtcag ctcggtcaag gtccgcagca
    17101 gtgcggtacc gggaccgtcg gtctccagct cggtgactga agccgggtcg gctggcgcga
    17161 tggtcacgtg gggctctccc tcgctcggca cgggggcctg gcgaagggca ggggcgacca
    17221 cgagcgcgca cggcgtcgcg tccaccagcc cactccgcga ggcccggacg tcagaacgca
    17281 cccggatcgg acgaccgggt gggctgccgg caggtcctcg gactgaacag gcgtgcggac
    17341 gcacgcgagt acaccgttgc gggacagttc cggattcgca ccggattccc ctgcgacgac
    17401 aacggggatg agcatacatc tagtgccggg ctgtcctgtc acccccagat gttgtgtcgc
    17461 tccggtctca gagggtcaac gcgtaagtga gcagcgtgag gtcggaacgg cccgggagcg
    17521 gattccagtc ccgctccggc gcgcgctcga agccgaggcg ttcgtagatg cggtgggcgg
    17581 tgcgcatcgt ccgctgcgtg gagagcacca cgccggcaca gccttcgacg gcccgcgccc
    17641 gctcgacaca ggcccgcacc agcgcctcgc cgacaccctg gccccgggcg gcgtggtcga
    17701 cggccagcat ccggatctcg gcctcgcccg ggcccgcgat gtcggtcatg gggccgccgg
    17761 agggaacgaa ggtgacgccg ccgaggaggc cggcgtcccg gacggccacg aggacctccg
    17821 cggcggcggc ccgcccggcg acgtcccgca gctcgcccag gtaccagtcg tcctcgtcga
    17881 aggcgaggag gccgtcccgg aggtacgcct gagcggtgat ctcgcccagc gcgccgtact
    17941 cctcggggcc ggcccgccgg atcaggaagt ccatgacacc gagtctgccc gaggggtacg
    18001 acgacgggcc gccggaagtc ctccggcggc ccgtcgaacg gcgcccggct agtgaccggc
    18061 gcccgcggtc gcggacggca gctccgcctg gaccccgggg tcaccggcgt ccgcggtgta
    18121 gtcctccggc ctggtctcgt cgaggccctc gggggccttc agcgccttca gcacgaaggt
    18181 caggaccacc gtgaccacga cgttgatcac gaacgccgtc aggccgatgt agccgatctc
    18241 gccgatgccc ggaatctcct tggcgctgcc gccgaagtgc ttctgggtgg gcgaggcgac
    18301 tccgtacgcc gccaccgtgc cgtagaccat gcccacagcc cagccggcca gcagcgccca
    18361 gcggtggaac cagcgggtga acagtccgcc gaccagggcc gggaaggtct gcaggatcca
    18421 gatcccgccc agcagctgga agttgatggc gacggtcttg tccatggtga ggacgaagac
    18481 cagggctccg accttcacca gcagcgacac gatcttggag acgcgggtct cctcggcggc
    18541 cgtggcgtcc ggcttgatga agtccttgta gatgttgcgg gtgaagaggt tggccgcggc
    18601 gatggacatg atcgccgccg ggaccagcgc gccgatgccg atcgcggcga aggccacgcc
    18661 cgcgaaccag tccgggaaca tgtcctcgaa cagctgcggg atggccagct ggccgttggt
    18721 gaccttcaca ccggccgcga tcgccatgaa gcccagcagc gccagcagac ccagcatgag
    18781 ggagtacagc ggcaggatcg tggtgttgcg gcggatcacc tcgcggctcc tggaggagag
    18841 cgtcgcggtg atcgagtgcg ggtacatgaa gagggccagg gcggagccca acgccagggt
    18901 ggcgtaggtc cattggcccg cctccgccgg gaccagcgcg ccgcgcggct tgccggtcgc
    18961 cgggttgacc tgggcgaagg cgtcgcccgc cttggcgaag acgtcgtcga acccgcccag
    19021 tttgatcggg atgtagatga tcgccaccgc gatgacgatg tagatcaggg cgtccttgac
    19081 gaacgcgatc agcgcggggg cgcgcaggcc cgaggagtag gtgtaggcgg ccagcacacc
    19141 gaaggcgatg agcagcggca ggtccttcac gaaccagttg gtgttctctc cgccgccgac
    19201 gcccatcacg tccagcaccg cctggatgcc gacgagctgg agcgcgatgt acggcatcgt
    19261 cgccaggatg ccggtcaccg cgaccgccag cgacaggccc ttcgagccga accggccgcg
    19321 cacgaagtcg gaggtggtga cgtacccgtg gcggtgcgag accgaccaga ggcggggcag
    19381 gaaggtgaag atcagcgggt acaccaggat cgtgtacggc accgcgaaga agcccgccgc
    19441 gcccgccgcg tagatggccg ccgggacggc gacgaacgtg tacgccgtgt acaggtcacc
    19501 gccgagcagg aaccaggtga cccaggtgcc gaaggaccgg ccccccaggc cccattcgtc
    19561 cagggactgc tcgttctcgg ccttgcgcca gcgcgcggcc aggaagccca tgaccgtgac
    19621 ggccaggaag aagaagatga agacgccgag cgcgacgccg ttgacgccgt ccttcacttc
    19681 accgcacccc cgttcgcgtc ctcgcgggcg cgctggtcac gcttccacag ctggtaggcg
    19741 agcatcgtga gcgcggtgga gatcagcacc cagagcatct ggtaccagta gaagaacggg
    19801 atcccgatga acgccgggtc cgtcttggcg tacgagccga cccacagcat cgccacgaag
    19861 ggcgcgacga gacacacggc gatgatcact cgggccggtg tcaccaccgg tggtctcact
    19921 tcaggcgttt cggacatgcc acggctccgt cccctcactg atcacctgta atgcgcaggc
    19981 aatctaggtg acggcgtcgt gacagcggaa gacctcgtcc gcatatcggt atatcgattc
    20041 agcgaacgcg cccggttgtt actccgccgg cctcttcagc cgggccacga acttgtaccg
    20101 gtcgccccgg tacaccgacc gcacccactc caccggcttg ccctcgcggt ccagcgagtg
    20161 gcgggagagc atcagcatcg gcaggcccac gtcggtgccg agcaggcccg cctcgcgcgg
    20221 ggtggccagg gaggtctcga tggtctcctc ggcctcggcg agatggacgt cgtagacctc
    20281 ggcgagcgcg gtgtacaggg aggtgtactt caccagcgag cgcctgaggg ccgggaagcg
    20341 cttggccgac agatgggtgg tctcgatggc catcggctca ccgttggcca tgcgcagccg
    20401 ctcgatgcgc agcacgcgcc cgccggcggt gatgtcgagc agttcggcga gccggtcgtc
    20461 ggcggtgaca taaccgatgt ccagcagctg cgaggtcggc tccagcccct gcgcccgcat
    20521 gtcctcggtg taggaggtga gctgcagcgc ctgggagacc ttgggtttgg cgacgaaggt
    20581 gcccttgccc tggatacgtt cgagccggcc ctccacgacc agttcctgca gggcctggcg
    20641 caccgtggtg cgggacgtgt cgaactcggc ggccagcgtg cgctcgggcg gcaccggagt
    20701 gcccggcgcc tgcgtctccg tcatgtcgag caggtgcttc ttcaggcggt agtacttggg
    20761 cacgcgcgcg gtacgggtgg tgccggcctc gttctccgca ctgctgacgt cggtggtcat
    20821 gctctgcctt cccggctccg aatgccgaaa gcgaccgaca tcccatcggc cacggctcac
    20881 atcgtggcac gggttgttgt gtcaggactc cacccgcacg ctccgtgatc ccctctatat
    20941 accgttgcgc ccgctgctgg tctagtccat cgcgcggcgg cgcgggcgcc cggcaccgcc
    21001 ccggccggcg ccgtcacacc tcgcggctcc ggttcgcg
//
