LOCUS       NZ_JACHJK010000006     22576 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Streptomyces echinatus strain CECT 3313 Ga0436950_06, whole genome
            shotgun sequence.
ACCESSION   NZ_JACHJK010000006
VERSION     NZ_JACHJK010000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces echinatus
  ORGANISM  Streptomyces echinatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 546324)
  AUTHORS   Whitman,W.
  TITLE     Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the
            genomes of soil and plant-associated and newly described type
            strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 546324)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 160.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014203595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 05:39:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,466
            CDSs (total)                      :: 8,381
            Genes (coding)                    :: 8,094
            CDSs (with protein)               :: 8,094
            Genes (RNA)                       :: 85
            rRNAs                             :: 7, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 5, 1 (5S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 287
            CDSs (without protein)            :: 287
            Pseudo Genes (ambiguous residues) :: 0 of 287
            Pseudo Genes (frameshifted)       :: 116 of 287
            Pseudo Genes (incomplete)         :: 236 of 287
            Pseudo Genes (internal stop)      :: 12 of 287
            Pseudo Genes (multiple problems)  :: 77 of 287
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 201732
            Orig. end                         :: 224308
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACHJK010000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22576
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="3"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22576
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22576
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12576](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12576)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            368..1513
                     /locus_tag="FHS34_RS18520"
                     /old_locus_tag="FHS34_003756"
     CDS             368..1513
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013998.5"
                     /locus_tag="FHS34_RS18520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003756"
                     /product="DUF58 domain-containing protein"
                     /protein_id="WP_184966679.1"
                     /transl_table=11
                     /translation="MLTRSGLVVALAAAILLSTGALLDYPELTLLGFACLIAILAAALW
                     MLAKPDLLVHRQIRPGRVTEGEEAVGVITVTNEMSRRCPPITAAEWVAGRSVGVPLPSL
                     APRAGHSMTYALPTSRRGVYKVGPLTIGHTDPLRLMAVTKQYATESTLYVHPQTDLVHP
                     VPTGQSRDQDGPTSSLAPQGGIAFHSLRDYVSGDDWRLIHWKSSARTGQLMVRHNVVPN
                     EPRLMILLDTSESPYTEKSFEDAVSAAASLCVAAVRAGFPLELRTTGGGMTAADQTGEG
                     LTPTLDLLAGVERDRQDPGLAALPSMVPEQGAVSLGVVTGQPEPAMLTALPQVRSRFMM
                     ISLVQFADTYAAPPSALHGVVSMNVRSREEFAATWNDLVRR"
     gene            1489..3780
                     /locus_tag="FHS34_RS18525"
                     /old_locus_tag="FHS34_003757"
     CDS             1489..3780
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023418.5"
                     /locus_tag="FHS34_RS18525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003757"
                     /product="transglutaminaseTgpA domain-containing protein"
                     /protein_id="WP_184966681.1"
                     /transl_table=11
                     /translation="MERSGTTMKSPSRTGEPVGVLHYAELALATLSVATTALVYGELFA
                     TKGHLVPLLAATAGAAVLATVTALLRRRTPTTVAVAVVGFVVVAVYAVLTPTLRHGIPT
                     LDTLDTLRTGVLRGWARILSVGLPADVSGELLITPALILFTAAFVAVSVSLRTRSLLGP
                     LAAPVLSLVAALLLTASRAGDELMLTGVLLPVLLLLVLIRAVRLDQTDIVTGTDGDSAA
                     RGTAGRTLFGLPVVVIVTVVGVVLSQAVPLATGSNRFDPRDVVSVPVEVEDTLTPLATL
                     KSQLQEKKPRELFTVRVDGNPLGGRLDRVRTAALDTYDGALWTSSDQFLVAGHTLAPDP
                     GLTPTARVALHVEIKQLDHPYLPAVGRPERVTAHGIGFSDDSGVLAADARTRPGLSYDV
                     VGAVRPRDSAARLALPRLTPDTKRYTTVPPELPAELSRAAVEITGGADEPYAKLVALEK
                     RLRSSPYSLSARPGHSLDALRRLFDDKQHKTAVGYAEQYAAAFVVLARSQGFPARVATG
                     YVLRPGERKGSTYTVRSTDAYAWAEVAMTGYGWMAFDPTDPTRKPTDKSDPKKPDRAGG
                     QNPAASDNRATDQGTIPNIPVAGGGRSAMDWALIVLGILLALVIVVPTLIALEKWRRRR
                     GRRTGPPSRQIVGAWRTSTDRLMETGMPVPRSLTALEVAGRAEHRLGETAAPVAVLAPL
                     VTEAVFSPAEPALEAVAQAWQADAALRSALRRDRGAAATVVAWFDPRPLIAGSRQDRRS
                     RKALKKLQGG"
     gene            3784..6252
                     /locus_tag="FHS34_RS18530"
                     /old_locus_tag="FHS34_003758"
     CDS             3784..6252
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039835.4"
                     /locus_tag="FHS34_RS18530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003758"
                     /product="PKD domain-containing protein"
                     /protein_id="WP_184966683.1"
                     /transl_table=11
                     /translation="MARARLTRAQLGEAARWLLRGRRASLIAWTLAGALALGVVVIAGA
                     EEGYTAKRPRLLSGAAWLPSTKAGQLALLDGATAEVAAQVKVSSGGGDLDVVQQDSHAY
                     VVNTSRGFVRRVNGATLAVTPALAGGDPGARPLPDAGKGLRVFAGPGVLYAVDTEHGVL
                     VQTDPVTLARRGDLQPLAADAAPESTVLDDHGALWALDDRTGDLNILRAGHRVTRRGVK
                     APGPGRLVVAGGAPVLVDTAARTASLLDRDSGEPASAVPLELRDGDEVAISGSPHSARL
                     YVVSRGVLTICELKSTNCGRAISLGRSGDGFGAAVENGGRLFVPNYVTGRVWIVDLATS
                     KVVAQPEVLDPPTRFQLLTRDGVVFFNDPASERAGIIRLDGDVLKVPKYDPGNPDKGLT
                     ERPDDEGGLSPEHPTERPDDPESSPAPTPSSDVSVPPDSSPPPDSGGTPPSQPSTGGPK
                     PLPSTGPSGPSTPPPPTTSPPPSTSPPPGPPTVSISLSQTTATTDEPVTLRATAPTGKP
                     SPTGATWTFGDGKTGSGVLTSHAWTTPDTFQINVTATFPGGRTAVAAASVQITERPVLT
                     VQTPLGGKVTGGGIDCAPTCTKAADPGETITLTAQPSTGFRVRGWGGACSGTAATCVVT
                     MDAGKTVSVQFARDSLALIPLAPAAAWRTGVGPIPWSGTSAVNGGPDANPDGFALLRPA
                     GSLLLEDRTDPEYLETHPQWVNNGWIEGDFTLPAPVVPGDRFRTTLGFMAVANPPSAGE
                     ADFVVLAVFPNGSVLELSRTHDRGDDGVMHPLDVDLSQAVGATKIRLRAEAGAKADQDW
                     CSWVNPRIEG"
     gene            6366..7673
                     /locus_tag="FHS34_RS18535"
                     /old_locus_tag="FHS34_003759"
     CDS             6366..7673
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHS34_RS18535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHS34_003759"
                     /product="hypothetical protein"
                     /protein_id="WP_184966685.1"
                     /transl_table=11
                     /translation="MTSTLTVAVAPAEITVRPGESVDVSVTVVNTGTLVSHYETTVVGL
                     PDAEHVQAEPPQVELNPKQTGTVSVRISVPAQGEPFAGRHVLGILVRAIGDQPASRCEE
                     LALTVPPVPALSAAVRPEVAEGGPSARFTVDVRNTGNTALPVTLSASNPENKVTFTCTP
                     RTVTVAPGAAVSVDMAVEAAAPWSGAQVRRTLKITAAAGQARAEQQATFVQSPRIRGGL
                     LKAAGLATGVLIMAASVLGAALLVRGGRPAAQPIRTPSPPASGPSTPSTPPNKATIIDF
                     GKERGDQLVPADRYTKQGITLSTVLERAPEQCADASALALRTVTGLGTFLTSARPTGVD
                     LCNTIPVQVDLAAPADTVRLTFAGKGAQYTLGAQLSDGSKAAADGTSQAGTATQLTYQA
                     PPGLSVVSFTFGHADPSPTSKDPTVIKQIAFTPAKF"
     gene            complement(8151..10004)
                     /locus_tag="FHS34_RS18540"
                     /old_locus_tag="FHS34_003761"
     CDS             complement(8151..10004)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988508.1"
                     /locus_tag="FHS34_RS18540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003761"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_184966687.1"
                     /transl_table=11
                     /translation="MTGATVPHGGRAAVAEADKSTWAAVATMYRLTAGHRSSIAVASVL
                     TLVGSTLGLVQPLVAKQVVDASGRGQVIWPLLALLGTLFVAEAATGAAGRFLLERMGEG
                     VVRQLRLGLVDRLLRLEMREYDRHRGGDLISRVTADTTLLREVVSQALVDLVTGSLVAA
                     GAIALMAWLDLLLLFLVAVTVAAATVVVASLLTGIRNASEHMQGSVGAVAADMERALGA
                     LPMVRVHGAEEREAAGIGAGVEAAYGAGVRTAKLASVMSSAVELAVQGSFLIVLVVGGL
                     RVGGHAGSLGDLVAFLLYASYLVLPLSSVFRAVGLVQRGMGAYQRIDEVLRLPVEPTAP
                     QIPKDRAPTLRPTRPSGSREQPVLALRDVHFGYDPQRPVLRGVSFTVPKRRHVALVGRS
                     GAGKSTVFALVARFYEPDAGTLLFDGRPATELTRGACRRDIAVVDQNTHVVHGTLRDNI
                     TYAVPDATEAEIRRVVELARLDEVVDRLSGGLAAVIGERGSKLSGGERQRVALARALLA
                     RPSLLLLDEPTSHLDAINESALTSVMKDVAQECALLVIAHRLSTVQHADHIVVLQDGRT
                     ATGGRHEELLVSSALYRELAASQMLRAGGKPGTGKRGRTDG"
     gene            complement(10001..10438)
                     /locus_tag="FHS34_RS18545"
                     /old_locus_tag="FHS34_003762"
     CDS             complement(10001..10438)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988507.1"
                     /locus_tag="FHS34_RS18545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003762"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_184966688.1"
                     /sec_met_domain="PF13471 (E-value: 4.5e-26, bitscore: 85.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALERPTGVPLARRLTARLVLLPAVAFALLPPRRIRAVLGF
                     LRRGAAPSTTEQAQNARDAMCAVSLRCAGPKGCLPRSLGAVLLCRLGGTWPTWCTGVRV
                     TPPFTAHAWIEAEGRPVGEGVPQGYFARLMAVDPLPRPTER"
     gene            complement(10435..10689)
                     /locus_tag="FHS34_RS18550"
                     /old_locus_tag="FHS34_003763"
     CDS             complement(10435..10689)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988506.1"
                     /locus_tag="FHS34_RS18550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003763"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_184966690.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 8.6e-26,
                     bitscore: 84.6, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.9e-16, bitscore: 54.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLRFGDNVSTAETDYGTVLLDEQAGAYWELNPTATVVVRTLLDG
                     GEEADAAAALVQEFDIDQAQALQDVETLVRELRDSGLAS"
     aSDomain        complement(10441..10683)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FHS34_RS18550_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.70E-27"
                     /identifier="RREFam002.1"
                     /label="FHS34_RS18550"
                     /locus_tag="FHS34_RS18550"
                     /protein_end="83"
                     /protein_start="2"
                     /score="84.6"
                     /tool="antismash"
                     /translation="LRFGDNVSTAETDYGTVLLDEQAGAYWELNPTATVVVRTLLDGGE
                     EADAAAALVQEFDIDQAQALQDVETLVRELRDSGLA"
     gene            complement(10726..12576)
                     /locus_tag="FHS34_RS18555"
                     /old_locus_tag="FHS34_003764"
     CDS             complement(10726..12576)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988505.1"
                     /locus_tag="FHS34_RS18555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003764"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_184966692.1"
                     /sec_met_domain="Asn_synthase (E-value: 9.3e-49, bitscore:
                     161.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELHESAGTGPGDAHFAVFTDRADAAAAARSFTRPGSRTLAHAS
                     GRPWLVGHWHDDEVVTAGAGGASLAVVGCCPIDADELRRRAARLRDLAQLDALVRSLPG
                     SFHLIGALDGQIRVQGTASGLRLVFHAEIDGVRVAATRADTLATVLGLDPDVEELAVRL
                     LWPAPYPLFETSMWRAVTAVPPQAAVVVAADGRTARHTQWWTPPEPVQPLTEAAPLIRR
                     ALQEAVDARTRQGGVVSCDLSGGLDSTSVCFLADRSPARVLASTWPGRDPADTDLHWAQ
                     RAMGHLPDVEHLVWDADASPLVYEDLLDIDDLLDEPTIGVMDRSRVLHHLPGLAARGSR
                     LHLTGIGGDHVAWCSEAYYHRLLRTRPLFALRQLRGFRALWQWPLGGTLRALADSRPYG
                     NWLADAAGDLRGPMSPSVATGLGWGMAPRLFDWVTPEAERMARRALLDAAATTSPLHPD
                     RGLHTDLEQIRSCTRVIRQWDRMAARAGLPMASPFLDDRVIEACLAVRPSERVTPWRYK
                     PVLSAAMRGIVPEECLRRSNKATASMDASNGLREHRADLLALWEDSRLAELGLVDGAEL
                     RRLARRPASPGLSDAILYSTIAAEVWLRGLARGRTHVPQP"
     gene            complement(12603..12713)
                     /locus_tag="FHS34_RS18560"
                     /old_locus_tag="FHS34_003765"
     CDS             complement(12603..12713)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656044.1"
                     /locus_tag="FHS34_RS18560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003765"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_184966700.1"
                     /transl_table=11
                     /translation="MKKAYEAPTLVRLGSFRKETGLLQRSGNDRLILSKN"
     misc_feature    complement(12889..12901)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     misc_feature    complement(13262..13280)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.49"
                     /tool="antismash"
     misc_feature    complement(13648..13662)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            complement(13791..14234)
                     /locus_tag="FHS34_RS18565"
                     /old_locus_tag="FHS34_003766"
     CDS             complement(13791..14234)
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144: thioesterase superfamily protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717268.1"
                     /locus_tag="FHS34_RS18565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003766"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_184966702.1"
                     /transl_table=11
                     /translation="MTTTDLTAMTGLELMRWVQTERPTDVPSIGRLLGMRFDEVAHGRI
                     VISLDTRPDFANPLGTVHGGIAATLLDSAMGCAVHTTLPAGTGYTTLELKVNYIRAART
                     DGQTLTAEGTVIHAGRRTATAEGKVLDDQGKLIAHATTTCMIL"
     gene            complement(14731..15402)
                     /locus_tag="FHS34_RS18575"
                     /old_locus_tag="FHS34_003767"
     CDS             complement(14731..15402)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (9-210). E-value: 3e-30. Score:
                     97.3. Matches aSDomain: nrpspksdomains_FHS34_RS18575_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006136021.1"
                     /locus_tag="FHS34_RS18575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003767"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_184966704.1"
                     /transl_table=11
                     /translation="MPSLDRQDNVFVLDLGDGENRFHPDWLTAVSAALDEVEKVEGPRA
                     LVTAATGKFYSNGLDLDWLSAHTDHYQDYVVTVHELFARMLSLPVITVAALQGHTFAAG
                     AMFSLAHDFRVMRADRGFWCLPEADINIPFTRGMAALIQSRLAPQTAHEAMITARRYGG
                     ADAAAAGIVDQAVTEEAVRSTAIEIAQAQVNKAGDTLGTIKARMYAPALATLRDTTNPL
                     G"
     aSDomain        complement(14773..15375)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHS34_RS18575_ECH.1"
                     /evalue="3.00E-30"
                     /label="FHS34_RS18575_ECH.1"
                     /locus_tag="FHS34_RS18575"
                     /protein_end="210"
                     /protein_start="9"
                     /score="97.3"
                     /tool="antismash"
                     /translation="VFVLDLGDGENRFHPDWLTAVSAALDEVEKVEGPRALVTAATGKF
                     YSNGLDLDWLSAHTDHYQDYVVTVHELFARMLSLPVITVAALQGHTFAAGAMFSLAHDF
                     RVMRADRGFWCLPEADINIPFTRGMAALIQSRLAPQTAHEAMITARRYGGADAAAAGIV
                     DQAVTEEAVRSTAIEIAQAQVNKAGDTLGTIKARMYAP"
     gene            complement(15447..16220)
                     /locus_tag="FHS34_RS18580"
                     /old_locus_tag="FHS34_003768"
     CDS             complement(15447..16220)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF047071.1"
                     /locus_tag="FHS34_RS18580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003768"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_225817516.1"
                     /transl_table=11
                     /translation="MVCRICMCMWPSGAIGTDSMIAGTCSCMFYGIHLKLLIGRPFGGP
                     YGHGEAGEQMSPRKSESRDRMVLSAAALLREYGASATSIDRVLAHSGAPRGSVYHHFPG
                     GRAQLIEEALALAADFLTGLIDTAMQVDDPVAAVDAFFRLWRDRLVESGFRAGCPIVAV
                     AVETNDDAPQLARSAAAVFARWQEALAAFLVRHGLTEERSRRLGAFMIAAVEGAVIMCR
                     AERSTAPIEAAAAEIHDLLLHALRDRPGAGSGPRP"
     misc_feature    complement(16113..16115)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16938..17819)
                     /locus_tag="FHS34_RS18585"
                     /old_locus_tag="FHS34_003769"
     CDS             complement(16938..17819)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012955.5"
                     /locus_tag="FHS34_RS18585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003769"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_221509116.1"
                     /transl_table=11
                     /translation="MALEYDVLVTLPPRAVLPDGSSVRPLPAWSPISATLIYGERDAIL
                     IDAPHLEEQSRQVAEWVLASGKNLVAMYATHGHGDHWFGFSEVAKHFPDARMIATEGTV
                     ALAEFTAGKRMAFWNSQFPGQIVKDIVLPEAIDDHTFLLEGEEVRFVEAGDSDAPDTTF
                     VHVPSVGLVVAGDIVYNGVHPYLAGGEKARPLPERRADWIAAIDKIAAVHPRAVVAGHK
                     NPANDDGPRHLDETRTYLQDTEEVAAVARHAKEFADLMLLRHLDRINPTMLALTAEHLY
                     PGTTVDGRAIEW"
     misc_feature    complement(17808..17822)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    18094..18108
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(18331..19371)
                     /locus_tag="FHS34_RS18595"
                     /old_locus_tag="FHS34_003770"
     CDS             complement(18331..19371)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134183.1"
                     /locus_tag="FHS34_RS18595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003770"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_184966708.1"
                     /transl_table=11
                     /translation="MSTPTISSLAFLTPGNFADDDPYTGLEETLQLFEYGERLGFDGAW
                     IRQRHLEHGVGSAAVFLAAAGQRTERVELGTAVIPIGYENPFRLAEDLALADVLSRGRL
                     QAGFSTGMPHAELLGDLVHDGDWHDFDLSYGRIARVIDHLRGDYLGGPDTVIRSPGNTQ
                     RPRLQPHAPGLVDRVWYGGGSLRSIRWAAEHGLNLLSGNIVTGEGTDDFTTAQLALLCE
                     HRRLITSDRSPRVALGRVIVPFDSADATTRARYRAYAASRHARTLAPQGPKRTLFAPDV
                     VGTADQILEQLTADPVVAAVSELRLELPYEFERADYEQILHDVRHSIAPELGWRPDSAL
                     LHEAVR"
     misc_feature    complement(19326..19340)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(19419..20243)
                     /locus_tag="FHS34_RS18600"
                     /old_locus_tag="FHS34_003771"
     CDS             complement(19419..20243)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126667.1"
                     /locus_tag="FHS34_RS18600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003771"
                     /product="DUF1684 domain-containing protein"
                     /protein_id="WP_184966710.1"
                     /transl_table=11
                     /translation="MTVHDTTADLSAFIHDWQEWHTRQEAELAAPHGFLAITGLHWLGE
                     EPQRLPDAPGAWSTGADGVVVILDDGEELVVDGAPVRGEHRFGVLPERGGVNAVWGDAV
                     IEVAKRGGHDIVRPRHPDNPLRTAFTGTPAYAPHPRWTVTGRYTAFDEPRPTTVGAAVE
                     GLEHVYDAPGRVEFELDGRPQALTAFPGRSPGSLLVLFTDATSGVTTYAANRALVLPPP
                     AADGTVVLDFNRAANLPCAYTDLATCPLPPAENRLSVAIEAGEKIPRERGGS"
     misc_feature    complement(20342..20356)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.59"
                     /tool="antismash"
     gene            complement(20440..20562)
                     /locus_tag="FHS34_RS43815"
     CDS             complement(20440..20562)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042934.1"
                     /locus_tag="FHS34_RS43815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative leader peptide"
                     /protein_id="WP_313149244.1"
                     /transl_table=11
                     /translation="MSVLYSSVPGPSLVCAATFSRFSRRRHIDLQRITSCLCHG"
     regulatory      complement(20592..20701)
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00634"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00634"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="SAM riboswitch class IV; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(20701..20717)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.0"
                     /tool="antismash"
     misc_feature    20816..20826
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(20840..20853)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.0"
                     /tool="antismash"
     gene            20881..20955
                     /locus_tag="FHS34_RS44185"
     CDS             20881..20955
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042934.1"
                     /locus_tag="FHS34_RS44185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative leader peptide"
                     /protein_id="WP_350839685.1"
                     /transl_table=11
                     /translation="MPISLRFTRRRAVDLLRVAAALCS"
     gene            21011..22273
                     /locus_tag="FHS34_RS18605"
                     /old_locus_tag="FHS34_003772"
     CDS             21011..22273
                     /EC_number="1.11.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009320492.1"
                     /locus_tag="FHS34_RS18605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_003772"
                     /product="vanadium-dependent haloperoxidase"
                     /protein_id="WP_184966712.1"
                     /transl_table=11
                     /translation="MHPLTTRRSALRALGSAALLAASGTVPSATAAVADERTSRPSVAL
                     DWYDLTAATIAAAGAATQITNNRTWAISWLAAARATREVPPGVDRRDFQDAALASAVHD
                     ALLALVPSRTQELDAALRTTLDRVPDGLARSKGVAAGARQARLVLASREGDGLDPASVN
                     APFTVPPAAPGVWQPTPPAYAPAAQYGNRLARPFLLDGPDQYRLPAPPALDSARYRADL
                     AEVRAYGAVDSTVRTALQTETATFWLGSSLTLYTEPLRVALARSPRFVPARAALVALFH
                     IALVDTQIATSDTKYAYLRWRPVTAIRAGTIDPDPDWTPLHVTPAHPDYPSGHNTYSGA
                     AETILTGLTGPRTAPFELTSPTAPGVTRTYTAWSQLSQDNEDARVYSGIHTRSADVAGL
                     ALGKRVAGHALRNAERLFGVS"
ORIGIN
        1 gtcaccaatg tcagcgagct cacgaagatg atccaggtgg cccgcgccac acacgtcgcc
       61 gacgcggtcc gctcgtacat cgtcacggtc gtcggaggca cccgcgccct caaggagaag
      121 gtgcggctcg gcgcaagtcc ccgggccagc aacgcccttg ccgtggccag tcaggccagg
      181 gccgcggtgg acggccgctc gtacgtcacc gccgatgacg tcaaggcgat ggcgcacccg
      241 gtgctgtgcc accggatcat cctcaccccg gaggcctcga tcaagggtgt gacgacgtcc
      301 tcggtcgtgg acgagatcct cgcctcggtt cccgtgccgc acgcttccgc gggtctgtga
      361 ggcgaggatg ctgacgcgat cggggctcgt ggtcgcgctc gcggccgcca tcctgctgtc
      421 gacgggcgcg ctgctggact acccggaact gacgctgctc gggttcgcat gcctgatcgc
      481 gatcctcgcg gccgcactgt ggatgctcgc gaagccggat ctgctggtgc accggcagat
      541 ccggccgggc cgggtgaccg agggcgagga ggcggtgggg gtcatcaccg tcaccaacga
      601 gatgtcgcgg cgctgtccgc cgatcacggc cgccgaatgg gtggccggac gcagcgtggg
      661 tgtgccgctc ccgagcctcg ccccgcgggc cggccactcc atgacgtacg ccctgcccac
      721 atcccggcgc ggggtctaca aggtgggccc gctgaccatc gggcacaccg atccgctgag
      781 gctcatggcg gtcaccaagc agtacgccac cgagtcgacg ctgtacgtgc atccgcagac
      841 cgacctcgtc caccccgtgc ccaccggcca gagccgtgac caggacggcc ccacctccag
      901 cctcgccccg cagggcggta tcgccttcca cagcctgcgg gactatgtct ccggcgacga
      961 ctggcggctg atccactgga agtccagtgc ccggacggga cagttgatgg tccgtcacaa
     1021 cgtcgtcccc aacgaacccc ggctgatgat cctgctggac accagcgaaa gcccgtacac
     1081 ggagaagtcc ttcgaggacg ccgtgagcgc cgccgcctcg ctctgcgtgg cggcggtccg
     1141 ggccgggttc ccgctcgaac tgcgcaccac aggtggcggg atgaccgccg ccgaccagac
     1201 cggcgagggc ctcaccccca ccctcgatct gctggccggt gtcgagcgcg accgccagga
     1261 cccgggtctg gccgcgctgc cctcgatggt gcccgagcag ggcgccgtat cgctcggtgt
     1321 cgtcacagga cagcccgagc ccgcgatgct caccgcgctg ccacaggtgc gctcccggtt
     1381 catgatgatc agtctggtgc agttcgccga cacctacgcg gcgcccccga gcgcgctgca
     1441 cggcgtggtg tcgatgaacg tccgcagccg cgaggagttc gccgccacgt ggaacgatct
     1501 ggtacgacga tgaagtcccc ctccaggacc ggcgagccgg tcggcgtcct gcactacgcg
     1561 gaactcgccc tggcgaccct ctcggttgcg accacggcgc tggtctacgg cgaactgttc
     1621 gccaccaagg gccacttggt tccgctcctg gccgccaccg cgggcgccgc ggtgctggcc
     1681 accgtcaccg ccctgctgcg ccggcgtacg cccacgaccg tggccgtcgc ggtggtcggc
     1741 ttcgtcgtcg tggcggtgta cgcggtactg acccccacgc tccggcacgg gattcccacc
     1801 ctcgacaccc tcgacaccct gcgtaccggc gtactgcgcg gctgggcccg gatactgagc
     1861 gtgggcctgc ccgccgatgt cagtggagag ctgctgatca caccggctct gatcctgttc
     1921 accgcggcgt tcgtggcggt gagcgtgtcc ctgcgcaccc gcagcctgct cggcccgctg
     1981 gccgctccgg tcctctcgct cgtcgccgcg ctgctgctga ccgcctcacg cgccggcgac
     2041 gaactgatgc tgaccggcgt cctgttgccg gtcctgctgc tgctcgtgct catccgggcg
     2101 gtacgcctgg accagaccga catcgtgacc gggaccgacg gcgacagcgc ggcgcgcggt
     2161 acagcgggac gcaccctgtt cggactgccc gtggtggtga ttgtcaccgt ggtgggtgtc
     2221 gtgctgtccc aggccgtgcc cctggccacc gggtcgaacc ggttcgaccc gcgggacgtg
     2281 gtgtccgtac ccgtcgaagt ggaggacacg ctcacgccgt tggccactct gaagagccag
     2341 ctccaggaga agaagcctcg cgagctgttc accgtccggg tggacggcaa ccccctgggc
     2401 ggacggctcg accgggtgcg caccgccgca ctggacacgt acgacggcgc cctgtggacc
     2461 tccagcgacc agttcctcgt cgccgggcac accctggcgc ccgaccccgg gctgaccccc
     2521 accgcacggg tcgcattgca cgtggagatc aaacagctcg accaccccta tctgcccgcg
     2581 gtcggccggc cggaacgggt caccgcccat ggcatcggct tcagcgacga ctccggcgtg
     2641 ctcgccgcgg acgcgcgaac gcggcccggc ctctcctacg acgtcgtcgg cgcggtacga
     2701 ccacgcgaca gcgcggccag gctggcgctg ccccggctga cgcccgacac caagcggtac
     2761 accaccgtgc cccccgagct gcccgccgaa ctgagccggg ccgcggtcga gatcaccggt
     2821 ggcgccgacg agccgtacgc caaactcgtc gcactggaga agagactgcg ctcgtccccg
     2881 tacagcctgt ccgcccggcc ggggcactcc ctggacgcac tgcgccgact gttcgacgac
     2941 aagcagcaca agacggcggt cggttacgcg gagcagtacg ctgccgcgtt cgtggtcctc
     3001 gcccggtccc agggcttccc cgcccgcgtg gccaccggct acgtactgcg ccccggcgag
     3061 cgcaagggca gcacgtacac cgtgcgttcc accgacgcct acgcctgggc cgaggtcgcc
     3121 atgaccggct acggctggat ggccttcgac ccgaccgacc cgacccgcaa gccgaccgac
     3181 aagtccgatc cgaagaagcc cgaccgcgcc ggcggccaga accccgccgc ctcggataac
     3241 agggcgaccg accaggggac catcccgaac atccccgtcg caggcggcgg ccggtcggcg
     3301 atggactggg cgctcatcgt cctcggcatc cttctcgccc tcgtgatcgt ggttcccaca
     3361 ctgatcgccc tggagaaatg gcgcagacga cgcggcaggc gtacgggccc gccgtcgcgg
     3421 cagatcgtcg gcgcgtggcg caccagcacg gaccggctca tggagaccgg tatgccggta
     3481 ccgcggtcac tgaccgccct ggaagtggcg ggccgcgcgg aacacaggct cggcgagacc
     3541 gccgcacccg tcgccgtcct cgcaccactg gtcaccgagg cggtgttcag cccggccgag
     3601 cccgcactcg aggcggtcgc ccaggcctgg caggcggacg ccgcgctgcg ttccgcgctg
     3661 cgccgcgacc ggggtgcggc ggccaccgtc gtggcgtggt tcgacccgcg cccgctcatc
     3721 gccggaagcc gtcaggaccg gcggtcccgc aaagctctga agaagctcca agggggatag
     3781 gccatggcca gggcacggct cacaagggca cagctggggg aggcggcccg gtggctgctg
     3841 cgcggccggc gtgcatccct gatcgcctgg acactggccg gggccctcgc cctgggcgtc
     3901 gtggtcatcg cgggcgccga ggagggctac accgccaagc ggccacggct gctctccggc
     3961 gcggcatggc tgccgtccac gaaggcgggc cagctcgccc tgctggacgg cgcgacggcc
     4021 gaggtcgccg cgcaggtgaa ggtctcctcg ggcggcggcg acctggatgt cgtccagcag
     4081 gactcacacg cctacgtggt caacacctcg cggggcttcg tacggcgcgt caacggcgcc
     4141 acgctggcgg tcacccccgc cctcgccggc ggcgacccgg gcgccaggcc cctccccgac
     4201 gcgggcaagg gactgcgcgt gttcgccggc cccggtgtgc tgtacgccgt ggacaccgag
     4261 cacggcgtcc tggtccagac cgacccggtg accctggccc gccgtggcga tctgcagcct
     4321 ctggcggccg acgcggcccc ggagtccacg gtgctcgacg accatggcgc gctgtgggcc
     4381 ctggacgacc ggacagggga cctgaacatc ctcagggccg ggcaccgggt gacccggcga
     4441 ggcgtgaagg ctcccggtcc gggccggctg gtggtggcgg gcggtgcgcc ggtgctggtc
     4501 gacacggcgg cgcgtaccgc gtcgctgctg gaccgggact ccggtgagcc ggcctcggcc
     4561 gtaccgctgg aactgcgcga cggggacgag gtggcgatca gcggctcgcc gcattccgca
     4621 cgcctgtatg tggtgtcccg gggcgtgctg acgatctgcg aactgaagtc cacgaactgc
     4681 ggccgcgcga tcagcctcgg ccgctccggt gacggtttcg gtgcggcggt ggagaacggc
     4741 gggcggctgt tcgtgcccaa ttacgtcacc ggccgggtgt ggatcgtcga cctcgccacc
     4801 tcgaaggtgg tggcccagcc ggaggtactc gacccgccga cccggtttca gctgctcacc
     4861 cgtgacggtg tggtgttctt caacgatccc gccagcgagc gggccggcat catccggttg
     4921 gacggcgacg tcctcaaagt gcccaagtac gaccccggca accccgacaa gggcctcacc
     4981 gagcgacccg acgacgaagg cggcctgtcg cccgaacacc ccaccgagcg gccggacgac
     5041 ccagagtcga gcccggcccc gacaccgtcc tcggacgtga gcgtgccccc cgacagctca
     5101 ccgccgccgg actccggcgg gacacccccg tcgcaaccgt ccaccggggg ccccaagccc
     5161 ttgccgtcga ccggtccgtc gggcccgtcg accccaccgc cgccgacgac ctcaccgccg
     5221 ccgtcaacct caccgccgcc gggcccgccg accgtgtcca tctccctgtc ccaaacgacc
     5281 gcgacaacag acgaaccggt gacgctgcgg gccaccgcgc cgaccggcaa accgtccccg
     5341 accggggcca cgtggacatt cggtgacggc aaaaccggct ccggagtgct caccagccat
     5401 gcgtggacga ccccggacac cttccagatc aatgtcaccg cgacgttccc cggtggccgg
     5461 acggcggtgg ccgccgcctc ggtccagatc acggaacgtc cggtgctgac cgtacagaca
     5521 cccctcggcg gcaaggtcac cggcggaggc atcgactgcg caccgacgtg caccaaggcc
     5581 gccgatccgg gggagacgat cacgctcacc gctcagccgt ccaccggatt ccgggtgcgc
     5641 ggctggggcg gcgcctgctc aggtacggcg gccacctgcg tggtgaccat ggacgccggc
     5701 aagaccgtgt cggtccagtt cgcgagggac tcgctggcgc tgatcccgct cgcgcccgcg
     5761 gctgcctggc gaacgggcgt gggccccatc ccctggagcg gcacctccgc cgtcaacggc
     5821 ggcccggacg ccaaccccga cggcttcgcg ctgctgcgtc cggccggcag cctgctgctc
     5881 gaggacagga ccgaccccga gtacctggaa acccatccgc agtgggtcaa caacggctgg
     5941 atcgagggcg acttcaccct gcccgcgccg gtggtcccgg gcgatcggtt ccgcaccacg
     6001 ctcggcttca tggcggtcgc caacccgccg tcggcgggcg aggccgactt cgtcgtgctg
     6061 gcggtgttcc ccaacggctc cgtgctggag ctcagccgca cacacgaccg cggtgacgac
     6121 ggcgtcatgc acccactgga cgtcgatctg agccaagccg tcggcgcgac caagatccgc
     6181 ttgcgggccg aggcgggcgc gaaggcggac caggactggt gttcctgggt gaacccgagg
     6241 atcgagggct aggagtgtcc gggtgggatc gggccggatc cctgagcccg gcgtgatccc
     6301 accggacgac gcccactgag gcgagccggc ctcatggccg acacacagga ggagacacca
     6361 tcccgatgac cagcacgctg acggtggccg tggcgccggc ggagatcacg gtgcggccgg
     6421 gggagtccgt cgacgtctcc gtgaccgtcg tgaacaccgg caccctggtc agccattacg
     6481 agacgaccgt cgtgggactg cccgacgccg agcacgtcca ggccgagccg ccgcaggtgg
     6541 agctcaaccc caagcagacc ggcaccgtct ccgtgcggat ctcggtgccg gcccaggggg
     6601 agccgttcgc ggggcggcat gtgctgggga ttctggtgcg cgcgatcggt gaccagcccg
     6661 cttcccgatg cgaggaactg gcactgaccg tgccgcccgt ccccgcgctg agcgccgcag
     6721 tgcgccccga ggtcgccgag ggcgggccgt ccgcccgctt cacggtggac gtccgcaaca
     6781 cggggaacac ggccctgccg gtgacgctga gcgcgagcaa cccggagaac aaggtcacct
     6841 tcacctgcac cccgcggacc gtcactgtgg cccccggagc cgctgtctcc gtggacatgg
     6901 ccgtggaggc cgcggcgccc tggtccggtg cccaggtgcg ccgcacgctc aagatcaccg
     6961 ccgccgcagg ccaggccagg gcagaacagc aggccacctt cgtacagagc cccagaatca
     7021 gaggcggact gctcaaggcc gccggactgg ccaccggcgt gctgatcatg gccgcctccg
     7081 tgctcggcgc cgcgctcctg gtccggggcg gcagaccggc ggcccagccc atccgcacgc
     7141 cctcgccccc ggcgtccgga ccgtcgactc cgtcgacgcc cccgaacaag gccacgatca
     7201 tcgacttcgg taaggaacgc ggcgaccagc tcgtccccgc cgaccgctac accaagcagg
     7261 gcatcaccct ctccacggtc ctcgagcggg cccccgaaca gtgtgccgac gcctccgcgt
     7321 tggctctgcg gacggtcacc ggtctcggca ccttcctcac cagcgcgcgc cccaccggcg
     7381 tcgacctctg caacaccatc cccgtccagg tcgacctcgc cgcgcccgcc gacacggtgc
     7441 gtctcacctt cgcgggcaag ggcgcccagt acaccctggg cgcccagctc tcggacggaa
     7501 gcaaggccgc cgccgacggc acgtcccagg ccggtaccgc cacccagctc acctaccagg
     7561 cgccgccggg tctgtccgtc gtgtcgttca ccttcggcca cgcggatccc agccccacgt
     7621 ccaaggaccc cacggtcatc aagcagatcg ccttcactcc cgcgaagttc tgagccgctc
     7681 ggtgttgtgc tgcttccggt tgttcgtggt ccacggggtg atgcgggcgc cgtcgtcggt
     7741 cgccatgttg taggcatcca gcggtaactg gccagcaccc aaacgccaca catgccgaga
     7801 cggctgccca aacaaaggcc tggtgggcgg cgtcacagcg gcctggtcct cgcggaagta
     7861 gcaggcgggg cgccttctca ccgcccttga cctgcacaaa gcaggcaggg agccgtcttc
     7921 caggagtcca gagtgctgcg tactctgttc aagtccaaga tctaacgttt gggtgttttt
     7981 gcaggtcagc ggcttgttag ccccgctcgg gtcagcaaac ggtcagcacc ggacgcggga
     8041 gcgtcccagc ttgccgacca ggtggccgcc atgacggggg agctgagaaa ggccgatggc
     8101 ccgtgcatgg gtccggatct cggccggctg ggccgcgaac gcgaaacgct tcaaccgtcc
     8161 gtccgccctc gcttgccggt cccgggcttc ccgccggccc ggagcatctg gctcgcggcc
     8221 agctcgcgat agagggcgct actgaccagc aattcctcgt ggcgtccgcc ggtggccgtg
     8281 cggccgtcct ggagcaccac gatgtggtcg gcgtgctgca cggtggacag gcgatgcgcg
     8341 atgaccagca gggcgcactc ttgggcgacg tccttcatga cggaggtgag cgccgattcg
     8401 ttgatcgcgt cgaggtggga ggtgggttcg tccagcagaa gcagcgaagg gcgggccagc
     8461 agcgcgcggg cgagggcgac gcgttgccgt tcaccgccag agagtttgct gccgcgttca
     8521 ccgatgacag cggccaggcc cccggacagc cggtcgacga cctcgtcgag cctggccagt
     8581 tcgacgacgc gccggatctc cgcctccgtg gcgtcgggca ccgcgtaggt gatgttgtcg
     8641 cgcaaggtgc cgtgcacgac atgggtgttc tggtcgacca cggcgatatc ccggcggcag
     8701 gcgccacggg tgagttcggt tgcgggccgc ccatcgaaga gcaaggtgcc cgcatccggc
     8761 tcgtagaacc gcgccaccag ggcgaacacc gtgctctttc cggcgccgga ccggcccacc
     8821 agggccacgt gccggcgctt cgggacagtg aacgaaacac cgcgcaggac cggccgctgc
     8881 gggtcgtagc cgaagtggac gtcgcgcagg gcgaggacgg gctgctcgcg ggagccggac
     8941 ggccgggtcg gccgcagtgt gggtgcgcgg tctttcggga tctggggtgc ggtgggctcc
     9001 acaggaaggc ggagtacctc gtcgatgcgc tggtaggcgc ccatcccgcg ttggacgagg
     9061 cccacagcgc ggaagacgga ggacagcggc agcacgaggt acgaggcgta cagcaggaac
     9121 gcgacgaggt cacccaggga gccggcatga ccgcctacgc gcaggccgcc gacgaccagg
     9181 acgatgagga aggagccttg aacggcgagt tcgacggcgg agctcatcac ggaggcgagc
     9241 ttcgccgtgc gcacccccgc gccgtaggcc gcctccacgc cggcgccgat gccggccgcc
     9301 tcacgctcct cagcaccgtg cacgcggacc atcggcaggg cgcccagggc gcgttccata
     9361 tcggcggcga cggcaccgac cgaaccctgc atgtgttcgg acgcgttcct gatgcccgtg
     9421 agcagtgagg cgaccaccac ggtcgccgct gccacggtca cggcgaccag aaacagcagc
     9481 agaaggtcca gccacgccat gagggcgatc gccccggcgg cgaccaggct tcccgtcacg
     9541 agatcgacca gagcctgcga gacgacctcc cgcagcaagg tggtgtcggc cgtcacccgg
     9601 gagatgaggt cgccgccccg gtggcggtcg tactccctca tctccagccg cagcagccga
     9661 tccaccagcc cgagccggag ttgtcgtacg acgccttcgc ccatccgttc cagaaggaag
     9721 cgtcctgcag cccccgtcgc cgcctcggcg acgaagaggg tacccaggag tgccagcagc
     9781 ggccagatga cctgtccgcg gccgctcgcg tcgacgacct gcttggcgac gagtggctgg
     9841 accagtccca gggtggagcc caccagggtc agtacgctgg cgacggcgat ggagctccga
     9901 tgcccggcgg tgagccggta catcgtggcc accgcagccc aggtggactt gtcggcttca
     9961 gcgaccgcgg cccgtccgcc gtgcgggacc gtcgcgccgg tcatcgttca gtaggccgtg
    10021 gcagcgggtc gacggccatc agccgggcga agtagccctg cgggactccc tcgccgacgg
    10081 gacggccttc agcctcgatc caggcgtgtg cggtgaaggg cggggtgacc cgtacgccgg
    10141 tgcaccaggt cggccatgtt ccgccgagcc ggcacagcag taccgctccc agggagcgcg
    10201 gcaggcaccc cttggggccg gcgcagcgca ggctgacggc gcacatggcg tcgcgcgcgt
    10261 tctgggcctg ctcggtggtc gagggagcgg cgccgcgccg cagaaagccg agcacagcgc
    10321 ggatgcggcg gggcggcagc agggcgaagg caacggcggg gagcaggacg aggcgggcgg
    10381 tgagacgtcg ggccaggggg accccggtgg ggcgctcgag cgcgctgggc gtcgtcatga
    10441 ggcgagcccc gagtcgcgca gctcccgtac gagcgtctcg acgtcctgca gggcctgcgc
    10501 ctggtcgatg tcgaactcct ggaccagggc ggcggccgcg tccgcctcct caccgccgtc
    10561 cagcagcgtc cgtaccacga cggtggccgt cgggttcaac tcccaatagg caccggcctg
    10621 ttcgtccagc agcaccgtgc cgtagtcggt ctcggccgtg gagacgttgt cgccgaaccg
    10681 caggggcatg tgagggcctt tctgacgtgc ctgacaggga tgcggtcagg gttgtgggac
    10741 gtgggtgcgg ccgcgggcga gtccgcgcag ccacacctcc gcggcgatcg tggagtagag
    10801 gatggcgtcg gagagccccg gggaggcggg ccgccgggcg aggcggcgca gctccgcgcc
    10861 gtccaccagg cccagctccg ccagccgtga gtcctcccac agggccagca ggtcggcgcg
    10921 gtgttcacgc agcccgttgg aggcgtccat ggaggccgtg gccttgttgc tgcgccgcag
    10981 gcactcctcg ggcacgatcc cgcgcatcgc ggcgctcagg acgggcttgt accgccaggg
    11041 cgtgacgcgc tcgctcggcc gtacggcgag acacgcctcg atgacgcggt cgtcgaggaa
    11101 gggagaggcc atcggcaggc cggcgcgggc cgccatccgg tcccactgcc ggatgacgcg
    11161 ggtgcacgag cggatctgtt ccaggtcggt gtggagccca cggtccggat ggagcggaga
    11221 ggtcgtcgcc gcagcatcga gcagcgcccg gcgggccatc cgttcggcct cgggagtcac
    11281 ccagtcgaac aggcgtgggg ccatccccca gccgagcccc gtcgcgacgg acggggacat
    11341 cgggccgcgt aggtcaccgg cggcgtcggc gagccaattc ccgtacggtc gggagtcggc
    11401 gagagcgcgg agcgtgccgc cgaggggcca ttgccacagc gcccggaatc cgcgcaactg
    11461 gcgcagggcg aacagcgggc gggtacgcag cagtcggtgg tagtacgcct cggagcacca
    11521 tgccacgtgg tcgccgccga tgccggtcag gtgcaaccgg ctgccgcgtg cggcgaggcc
    11581 aggcaggtgg tgcaggaccc gggagcggtc catgacgccg atggtgggct cgtcgagcag
    11641 gtcgtcgatg tcgagcaggt cctcgtagac cagcggcgag gcgtcggcgt cccagaccag
    11701 gtgctcgacg tccgggaggt gccccatcgc ccgctgggcc cagtgcagat cggtgtccgc
    11761 cggatcacgt cccggccacg tactggccag cacgcgggct ggggagcggt cagccaggaa
    11821 gcagacggag gtcgagtcca ggccgcccga caggtcgcag ctcaccacgc cgccttgacg
    11881 ggtacgcgcg tcgacggcct cctgcagtgc cctccggatc aggggcgccg cttcggtgag
    11941 cggctggacc ggctccggcg gcgtccacca ctgagtgtgc cgtgcggtgc gcccgtccgc
    12001 tgcgacgacc acggcggctt gcggaggaac ggcggtgacc gcacgccaca ttgatgtctc
    12061 gaacagcgga tacggggcgg gccacagcaa ccgtacggcc agttcctcca cgtcggggtc
    12121 caggcccagg acggtggcca gcgtgtcggc gcgggtcgcc gccactcgca cgccgtcgat
    12181 ctccgcgtgg aaaacgagtc gcagcccgga ggcagtgccc tggaccctga tctgtccgtc
    12241 gagggcgccg atgaggtgga aactgccagg gagggatcgg accagtgcgt cgagctgagc
    12301 gaggtcacgc aaccgtgcgg cccggcgccg cagctcgtcg gcgtcgatcg ggcagcatcc
    12361 gacgacggcg agggaggcgc cgccggcgcc ggccgtgacg acctcgtcgt cgtgccagtg
    12421 gccgaccagc cacggccggc ccgacgcatg cgcgagggtc cggcttccgg ggcgggtgaa
    12481 ggagcgggcc gcggcggccg cgtccgcacg gtccgtgaag accgcgaagt gcgcgtcgcc
    12541 ggggcccgtc cccgcacttt cgtgcagttc agtcatgacg tcgggtcaag gaccgtcggt
    12601 cgtcagttct tgctcaggat cagccggtcg ttgccggagc gctgaaggag ccccgtctcc
    12661 ttccggaacg aaccgagccg gacgagcgtc ggtgcctcat atgccttctt cacgactact
    12721 cctcactgca ggcttcgcga acacatccct gaccgacggc ccggggactg gccgatgtgc
    12781 tgtcggtcgg cccagggctc atcgggaacc cgggccagga agtggcgcag caatagctag
    12841 ctgcagagcg tgagatcacg gcaagagccc ttgcgaagct cggataatat gcaaaattcg
    12901 aatccccctg gttgcgcacc cgctcccgtt ccggttgtcg tcggtgcggc attgttgtgt
    12961 gacccgggtg tacacatgct cgattgaacg ttttgacatg cgttccggcg gtcgctcgtc
    13021 gctcctgcca ggacgcgtcc gacggccgtc acgggggggc gccgccgggg cgcgctccgt
    13081 gccctcgatg tgctcccctt cggtccgctc ctaatcggtc gccagggaaa tcacacgtcg
    13141 tcagccctca acgacaccac gccacaaagg ttggtaaccg tcacgcgtgt gcgcatacga
    13201 ctggcgcgcc gtcaggaaag tcagcaacgg gtcagtgtga gtcctggaac acctggcgac
    13261 agctgggtgt ttttgcaggt caagcccctg atcgctgcct ccgggtcagc aaacggtcag
    13321 catcgattcg gacggtgtcc ggcttgctga cctgcacgta tgacatgggt ctgccgggcc
    13381 gtccacgccc tgctcgcaag gcttgatacg tggctcgaca gctcgcccgt gggatggggt
    13441 cgttcttcaa ggagtgtggt tgttccaggt cgacccgtca ctcgcacccg tacacgattc
    13501 ggttccgtga cggtctcggc aagcagcgtg aagaggtcgg ctacgacgtc ctcgccgtcg
    13561 acgagctgtg tgccgcggac gccgagagat cgcccagcac aaggaagacg tcgaagctct
    13621 catcggcgcc ctgcaccagg ccacggtcga aaaccagatc cagcgccagc agccggctag
    13681 ggcagcgcgc tgccatcgtc cacgcgctgc ccccccccgc agcctcggcc gccgacggcc
    13741 cacgcggaac gtgaccttca cggcaggtga agccgacctc ggcgagcgac ctaaaggatc
    13801 atgcaggtgg tggtggcgtg ggcgatcagt ttgccctggt cgtccagcac cttgccttcg
    13861 gcggtcgccg tacggcggcc ggcgtggatg acggtgccct cggcggtgag ggtctggccg
    13921 tcggtgcggg cggcgcggat gtagttgacc ttgagttcga gggtggtgta gccggtgccg
    13981 gcggggaggg tggtgtggac ggcgcagccc atggcggagt cgaggagggt ggcggcgatg
    14041 ccgccgtgga cggtgccgag agggttggcg aagtcggggc gggtgtcgag ggagatgacg
    14101 atgcggccgt gggcgacctc gtcgaagcgc atgccgagca ggcggccgat ggaggggacg
    14161 tcagtggggc gttcggtctg cacccagcgc atcagttcca ggccggtcat ggcggtgagg
    14221 tcggtggtgg tcacgggtcg ttctccttgc gaggtgctgg tggtgccgcc ccgaggggcg
    14281 gggtgttcat caggcgggga ggggctggac acggacggga acgtgcttgt gccagggggt
    14341 tccggcgatg gggtcgcgcc aggtgaggtc agtgagggtg ttcagggcga cgccggtgcg
    14401 ttcgttgccg ccgtcgtggg tgggcaggtc gaggccgaag ccgttcggca gggccgcgtc
    14461 ccgggctgca ggcgggcgtc gctctcgacc accgcctcag cggtgccgcg cgacgcggtg
    14521 atctgggcga gggcgccgtc ggacaggctc agccgttcgg cgtcgtgtgg gccggcgcgc
    14581 agggcgtcct gctggtcgcg ctcgcgccag gtgttgtcgc ggaagatggt gtttgcggtg
    14641 aacgccctga tgcggtgggc agttggggca gcccgtgccc ccgggagacg gcgcccgggg
    14701 cacggcttgg tgcggtcggt ggggtgctgg tcagccgagc gggttggtgg tgtcgcgcag
    14761 ggtggccagg gccggtgcgt acatgcgggc cttgatggtg ccgagggtgt cgccggcctt
    14821 gttcacctgt gcctgggcga tctcgatcgc ggtggagcgc acggcttcct cggtgacggc
    14881 ctggtcgacg atgccggcgg ccgcggcgtc ggcgccgccg tagcggcggg cggtgatcat
    14941 ggcctcgtgc gcggtctgcg gcgccagccg ggattggatg agggcggcca tgccgcgggt
    15001 gaaggggatg ttgatgtccg cttcgggcag gcaccagaag ccgcggtcgg cgcgcatgac
    15061 gcggaagtcg tgcgcgaggg agaacatcgc gccggcggcg aaggtgtgcc cctgcagcgc
    15121 ggccaccgtg atgaccggca gcgacagcat ccgcgcgaac agctcatgga cggtgaccac
    15181 gtagtcctga tagtggtcgg tgtgggcgga cagccagtcc aggtcgagcc cgttggagta
    15241 gaacttgccg gtggcggcgg tgaccagggc gcgagggcct tccaccttct ccacctcgtc
    15301 gagcgcggcg ctgacggcgg tgagccagtc ggggtggaag cggttctctc cgtctcccag
    15361 gtcgaggacg aagacgttgt cctgacggtc gagtgagggc atggcgactc cttcgggctg
    15421 agctgactcg gacaagcgac tgcgggctac ggccggggac cggatccggc accggggcgg
    15481 tcgcgcaggg cgtggaggag caggtcgtgg atctcggcgg cggctgcctc gatcggggcg
    15541 gtgctccgtt cggcccggca catgatcacc gcgccttcga cggcggcgat catgaaggca
    15601 ccgagccggc ggctgcgttc ctcggtcagg ccgtgccgga cgagaaaagc cgcgagggcc
    15661 tcctgccagc gggcgaagac tgcggcggcc gagcgggcaa gctggggtgc atcatcgttg
    15721 gtctccacgg ccaccgccac gatcgggcag ccggcccgga agccgctctc cacgagccgg
    15781 tcacgccaca gccggaagaa cgcgtcgacg gccgccaccg ggtcatccac ctgcatcgcg
    15841 gtgtcgatca gccccgtgag gaagtccgcc gccagtgcca gcgcctcctc gatgagctgc
    15901 gcccgcccgc cggggaagtg gtgatacacc gagccccggg gagctccgct gtgggcgagc
    15961 acccggtcga tgctggtcgc gctcgcaccg tattcacgca gcagagctgc agcactgagg
    16021 accatccggt cacggctttc actcttgcgc gggctcatct gctcaccggc ttccccatgg
    16081 ccatacggcc caccaaacgg tctacctatc agtaacttaa ggtgtatgcc atagaacatg
    16141 caagagcagg tgccggcgat catcgaatcc gttccgatgg cgccgctcgg ccacatgcac
    16201 atacagatgc ggcagaccac ggcctccttc cgcgcttcca gcgccccgtc caggctgtct
    16261 cggtgaggct ttgatgcagg tccgagcaga tgcggccgag ctgcatcgca ccaggttctc
    16321 cgcctcgctc cgcagatgac actcagcacg gccacaacgt cagggcgtgg gcaggtgccg
    16381 gcgcacccag ccggccagca gctcgctctg tccgacgtcc tcggtgagtg gtagcggaag
    16441 cggggattcg gggcgagggg tgtgccgtcg tactccagca gcggacgtat gccgagcaga
    16501 tcgctgatct ccccgcggag ggctccgacg tcccggtccg ggcccacacg cagccgcgcg
    16561 tccagagccg gcagccgccc gtcgagccac tgcccctgcg gttcttcgcc gccgccaatg
    16621 tcggggttca gccacgaggg gtgaaggggg tccagaagcc ggagtgcgcc cgcgggaagg
    16681 cggtcatccc gtccctcgac catgtgaaaa cggcgccggc cgccgcggat cacatccttg
    16741 cgttccgaga ggttcctctg ccgcgctcgc tgcgggaagc gatggaacgc cacgaggaga
    16801 agcacggcac cacgaaagac ggctacctgc tgcgcggtcc gagcggctct ttcccgggac
    16861 ccgggctccg tcgttctcgc gctcggcccg acgtggctgg tatcggccgt ggtgccggtg
    16921 cccgcgggag tggtgtgtca ccactcgatg gcgcgtccgt cgacggtcgt tccggggtag
    16981 aggtgttcgg cggtcagggc cagcatggtg ggattgatgc ggtccaggtg gcgcagcagc
    17041 atcaagtcgg cgaactcctt ggcgtggcgg gcgacggcgg ccacttcctc ggtgtcctgc
    17101 aggtacgtgc gagtctcgtc caggtggcgg gggccgtcgt cgttggcggg gttcttgtgt
    17161 ccggcgacga cggcgcgagg gtggaccgca gctatcttgt cgatggcggc gatccagtcc
    17221 gcgcgccgct cgggcagcgg ccgggccttc tcgccgccgg cgaggtaggg gtggacgccg
    17281 ttgtagacga tgtcgcccgc gacgacgagg ccgacggacg gcacgtgcac gaacgtggtg
    17341 tccggtgcgt cgctgtcgcc ggcctcgacg aacctgacct cttcgccctc caggaggaag
    17401 gtgtggtcgt cgatcgcctc gggcagcacg atgtccttga cgatctggcc gggaaactgg
    17461 ctgttccaga acgccattcg ctttccggcg gtgaactccg ccagggccac ggtgccctca
    17521 gtggcgatca tccgcgcgtc gggaaagtgc ttggcgacct cggagaatcc gaaccagtgg
    17581 tcgccgtggc catgagtggc gtacatggcg accaggttct tgcccgaggc cagcacccat
    17641 tcggccacct gccgggactg ctcctccagg tgcggggcgt cgatcaggat ggcatcccgc
    17701 tccccgtaga tgagggtcgc cgatatcggc gaccaggccg ggagaggccg gaccgaggaa
    17761 ccatcgggca ggaccgcccg gggaggaagg gtgacgagca cgtcgtattc gagagccatg
    17821 attttctgct ttctgtactt tcaatgctct gttcctattt ttgccagacc atccgaaatg
    17881 gttcctgtcg ggttggtgaa ctcgttggtg gcggtgacgg caacgcatga tcaggtgtgt
    17941 gctctcggcc gcgccgaaat ccccaagcgc tcggtcgcgt gaaagagcga gttggacctg
    18001 caacgccggt tcgctgcgga tacgacacgg cccattccga ggcgcgcatg ccgcccatgg
    18061 atccgccgac gaccagggcc cagcgatcga tgccgagggc gtcggccagg caagcttccg
    18121 cagcgacctg atcgctctgt ggccaaagag gggaggtggc accccagtgt cgttcgtcgg
    18181 gacgcatgga ggacggtcca gtactgccct ggcagccgcc cagcacatcg gcacctcgta
    18241 cgccccggca tcggttgaag cggcggccgt cggcgaaacg gctcccgggt gtggatctcc
    18301 ggccgcacgg cggctcccgc ggatcggggc tcatcggacc gcctcgtgca gcagcgcgga
    18361 gtcgggccgc cagcccagct cgggcgcgat cgagtgccgt acgtcgtgca ggatctgctc
    18421 gtagtcggcc cgttcgaact cgtagggcag ctccaggcgc agctccgaga cggccgcgac
    18481 cacgggatca gcggtcagct gctccaggat ctggtccgcg gttcccacca cgtccggggc
    18541 gaacagggtc cgcttcgggc cctgcggcgc cagggtgcgt gcgtgccgac tggccgcgta
    18601 cgcacggtag cgggcccggg tcgtcgcgtc cgcgctgtcg aacggcacga tcactcgtcc
    18661 caacgccacc cgtggcgagc ggtcgctggt gatcaaccgc cggtgttcgc agagcagggc
    18721 gagctgggcc gtggtgaagt cgtcggtgcc ctcgcccgtc acgatgttgc cgctgagcag
    18781 gttcaggccg tgctcggcgg cccagcggat cgagcgcaga cttcccccgc cgtaccagac
    18841 ccggtccacc aggccggggg cgtgtggctg caggcgcggc cgctgggtgt tgccgggcga
    18901 ccggatgacc gtgtcggggc cgccgagata gtcgccgcgc aggtggtcga tgacacgggc
    18961 gatcctgccg tacgacaggt cgaagtcgtg ccagtccccg tcgtggacca ggtcgccgag
    19021 gagttcggcg tgcggcatgc cggtgctgaa gccggcctgc aggcggccgc gggacagtac
    19081 gtcggcgagc gccaggtcct cggcgaggcg gaacgggttc tcgtacccga tcgggatgac
    19141 cgcggtcccc agttccaccc gctcggtgcg ctggccggcg gcggcgagga acaccgcggc
    19201 cgagccgaca ccgtgttcga gatggcgttg ccggatccag gcaccgtcga agccgagtcg
    19261 ttcgccgtac tcgaacagct gcagggtttc ctccaggccg gtgtacgggt cgtcatcggc
    19321 gaagtttccc ggagtgagaa aggccagcga gctgatcgtg ggtgtgctca tgcggtctcc
    19381 gccctcttcg tcgtggtccc ctcggtggcg caaggtgttc aggagccgcc ccgctcacgt
    19441 gggatcttct ccccggcctc gatcgccacc gacagccggt tctcggcggg cggcagcggg
    19501 caggtggcca gatcggtgta ggcgcacggc aggttcgccg cccggttgaa gtccaggacg
    19561 accgtgccgt cggcggcggg cggggggagg acgagggccc ggttggcggc gtaggtggtg
    19621 accccggacg tcgcgtcggt gaacagcacc agcagactgc ccggactgcg tccggggaac
    19681 gcggtgaggg cctggggccg cccgtccagt tcgaactcga cccggcccgg cgcgtcgtac
    19741 acgtgctcga gaccctcgac cgccgcgccc accgtcgtcg gtcgtggctc gtcgaaggcc
    19801 gtgtagcggc cggtcaccgt ccagcgggga tgcggggcat aggcgggcgt gccggtgaag
    19861 gcggtgcgca aggggttgtc cgggtgccgg ggacggacga tgtcgtgtcc gccgcgcttg
    19921 gccacctcga tcacggcgtc gccccagacc gcgttgactc cgccgcgctc cgggagcacc
    19981 ccaaagcggt gctcgccgcg gacgggggcg ccgtccacga ccagttcctc accgtcgtcg
    20041 aggatgacga cgaccccgtc ggccccggtc gaccaggcgc ccggagcgtc cgggagacgc
    20101 tgcggctcct cgcccagcca gtgcagcccg gtgatcgcga ggaacccgtg cggggcggcg
    20161 agttctgcct cctgcctggt gtgccattcc tgccagtcgt ggatgaaggc ggacaggtct
    20221 gcggtggtgt catgaacggt catgcggact cccttgctcg catcggcttg atgcggccgt
    20281 ggcacggcgg ccgcggggat caccgcgagc agctcgcgga tgtcggtgtg gcgggggtgg
    20341 gtgaacacga aagcctcgtg gggacgaggc gggaacgaca gaagagcgcc gtggacgtcg
    20401 aacagcgctg aacgtcctca ggcagccggc gggacgcggt cagccatgac acagacagct
    20461 ggtgatgcgc tgcagatcga tgtggcgtcg gcgggagaat cgagagaaag tcgccgcaca
    20521 cacgagggag ggaccgggga cgctgctgta caacacgctc acccctccgt gtcccaggcc
    20581 cctgccacgg cgccacgcgc ttgccggatc ggcgacccgg ccgggctttc acctggagca
    20641 ccccaccgcg tcggagggtt gccggtcagc aagccagggc ttgacgctga cactcaatgc
    20701 cggttgaaaa gctacctatc gccgccgtag cccgtcaatg tcgagagacg agccgtcgct
    20761 tcgtctcgaa aggtactcgg gtaacgggcg tatggcgggg acgcgaagcc gtcattgcaa
    20821 tgtcaggcgg gcaacctcct tttgttgacc aagggttggg gcctggatag cgtccccggc
    20881 atgccgatct ccctgcggtt cactcggcgg cgcgccgttg atctgctgcg tgtcgccgcc
    20941 gcgctgtgta gctgaccctc acctgcgccc cggtcaacag cagtcaccgc atatccgcga
    21001 gggagtaccc gtgcatccgc tcaccacccg ccgctccgcc ctgagggcgc tgggctcggc
    21061 cgccctgctg gccgcctccg gcaccgtccc gtccgccacg gctgccgtgg cggacgaacg
    21121 gacgtcgcgc ccgtccgtgg cgctcgactg gtacgacctg acggccgcta ccatcgcggc
    21181 cgccggcgcc gccacccaga tcaccaacaa ccgtacctgg gccatcagtt ggctcgcggc
    21241 ggcccgagcc acccgcgagg tgccgcccgg cgtcgaccgg agggacttcc aggacgcggc
    21301 cctggcgtcc gccgtacacg atgccctgct ggccctggtc ccgtcccgca cccaggaact
    21361 ggatgccgcg ttgcgaacca ctctggaccg cgtcccggac gggttggcca ggtcgaaggg
    21421 tgtggcggcc ggtgcgcgcc aggcacggct ggtcctcgct tcccgcgagg gcgacggtct
    21481 cgacccggcc tcggtcaacg cgcccttcac cgtgccgccc gcggctcccg gcgtgtggca
    21541 gccgacgccg cccgcctacg cccccgccgc acagtacggc aaccggctcg cgagaccctt
    21601 cctgctggac ggccccgatc agtaccggct gcccgcaccg cccgccctgg actccgcgcg
    21661 ctatcgtgcc gacctggccg aggtacgggc gtacggggcc gtggacagca ccgtgcgcac
    21721 agcgctgcag accgagaccg ccaccttctg gctgggctcc tcactgacgc tgtacaccga
    21781 gccgctgagg gtcgccctcg cccggtcgcc acgcttcgtc cccgcacggg ccgcgctggt
    21841 ggcgctgttc cacatcgccc tggtggacac gcagatcgcc acctccgaca ccaagtacgc
    21901 gtacctgcgc tggcgccccg tcacggccat ccgcgccggc acgatcgacc ccgaccccga
    21961 ctggacgccg ctgcacgtca cgccggccca ccccgactac cccagcggcc acaacaccta
    22021 ctcgggcgcg gcggagacga tcctgacggg gctcaccggg ccgcggaccg caccgttcga
    22081 gctgaccagc cccaccgccc ccggagtgac gcgcacatac acggcctgga gtcagctgtc
    22141 ccaggacaac gaggacgccc gcgtctactc cggcatccac acccgctcgg ccgacgtggc
    22201 cggcctcgcc ctcggcaagc gggtggcggg gcacgcgctg cgcaacgcgg aacgtctgtt
    22261 cggcgtgtcg tgaacgattc gggatgcggc cacccggcgg ccccgtcccg aacctcgtta
    22321 cccgacacgg cggccgcctc ccgcagtgcc tgagccgccg cctggggtga gtccgggcca
    22381 ggggcgtccg ggtggcaggt gaccgagcgg agggcgccgg tgtagcggaa gacgccgtgg
    22441 cgctcgtaca gcggccggga gaccggcgac ttgcggtcga ggtccacgct gacgccctgg
    22501 aacggggcca tgccgatgag ctggtggacc ggtcacggtg cggcgcgttc ggcgccgtcc
    22561 acggcgagcg cgaagc
//
