LOCUS       NZ_JACHJK010000003     21251 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Streptomyces echinatus strain CECT 3313 Ga0436950_03, whole genome
            shotgun sequence.
ACCESSION   NZ_JACHJK010000003
VERSION     NZ_JACHJK010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces echinatus
  ORGANISM  Streptomyces echinatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 825906)
  AUTHORS   Whitman,W.
  TITLE     Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the
            genomes of soil and plant-associated and newly described type
            strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 825906)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 160.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014203595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 05:39:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,466
            CDSs (total)                      :: 8,381
            Genes (coding)                    :: 8,094
            CDSs (with protein)               :: 8,094
            Genes (RNA)                       :: 85
            rRNAs                             :: 7, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 5, 1 (5S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 287
            CDSs (without protein)            :: 287
            Pseudo Genes (ambiguous residues) :: 0 of 287
            Pseudo Genes (frameshifted)       :: 116 of 287
            Pseudo Genes (incomplete)         :: 236 of 287
            Pseudo Genes (internal stop)      :: 12 of 287
            Pseudo Genes (multiple problems)  :: 77 of 287
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 788798
            Orig. end                         :: 810049
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACHJK010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21251
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="atropopeptide"
                     /region_number="6"
                     /rules="atropopeptide_p450"
                     /tool="antismash"
     cand_cluster    1..21251
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21251
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11251](-)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11251)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     misc_feature    115..128
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.57"
                     /tool="antismash"
     misc_feature    complement(115..131)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.53"
                     /tool="antismash"
     misc_feature    complement(178..192)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            197..703
                     /locus_tag="FHS34_RS12285"
                     /old_locus_tag="FHS34_002494"
     CDS             197..703
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889155.1"
                     /locus_tag="FHS34_RS12285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002494"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_184964129.1"
                     /transl_table=11
                     /translation="MSDAVDAIIGQWAEERPDVVEDLWPVQLFGRIQRLARVVDKSARA
                     AAAAHGVEHGEFDVLTTLQRSGPPYTLTAGAFVKASMVTSGAITNRIDKMEAKGLVERV
                     RDDDDRRTIKIRLTEHGHEITRAAFADHLANYAQLLADVDRGVVDKTAEGLRRVLESLG
                     DTTIK"
     gene            complement(923..3838)
                     /locus_tag="FHS34_RS12290"
                     /old_locus_tag="FHS34_002495"
     CDS             complement(923..3838)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572677.1"
                     /locus_tag="FHS34_RS12290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002495"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_184964131.1"
                     /transl_table=11
                     /translation="MRFGILGETRAWHDDDEVPLGGPARRALLALLLVRPGEVVSTDRL
                     ADEIAPTGALSAHSLQSQVSRLRTALGAAAAIERAGAGYRIVIDPDDVDAFRFERLAGE
                     GRAALADGEAGRAVVLLHEALELWRGPVLADLPESETAQAVAVRLEERRLVALEDRIEA
                     ELRLGEHRAVVPELRELVGRHPLRERLAGLLMRALFAEGGQAEALVVFEATRRHLADEL
                     GADPSAELTALHRELLSTDPTASPAAPPAQLTNFVGRADEVTEVAEALRVARLVTLLGP
                     GGVGKTRLSVEVAGAADVAGQVCFVELAPLRDGAGLPHALLGALGLRENGLQMGGGATA
                     PVDRLIAALSDQVLLLVLDNCEHLVDEVAGLAARLLAACPRLRVLATSREPLGIIGEHL
                     YPVRPLDEDAAVRLFTERAGAVRRGFTADPEVVRRICAALDDLPLAIELAAARSRTLDI
                     DDLAGRLDDLLAVGARGNRTADERHRTLRSVVAWSWDLLSEPEQRAARRFTVFAGGATA
                     RSAVRVCGTDAETLEALADKSLLEVAGGRYRMLETIRAYGAERLDAAGERESVRRAHAQ
                     RLLELVRTADPHLRRAEQLEWLAVVAAEHEDLLAALRWAVEEPAVQTAFELLAAAFNYL
                     WIRGASASVAPLAIALLASVGEAVPDGLGEEYATCVLLAGAASATDGAGERMWQRHRAT
                     AGKALAAAWPGDRSGRYPVVVLLWMMRNAGGPSPQDAFALVSSQRDCPEPWTRAAAHYV
                     SGFGHLGRRDPAAAEVAFGQALEGFRSLGDRWGMALALDTLAGVAGARGDRTRAVGLTD
                     EALVLTERLDALEDSADLLVNRGDHLAGDDAAGARTAYANAAALARRAGSSTYLAAALR
                     GLGDIALEEGDLAEAERLYSEALERIDPHWIKSLGPRVRTLIGLGRVAAARSHHAKARE
                     HYRQAAEVADTAGARAPEVLRMLGLSEKTVGCVLEAVAADR"
     gene            complement(3878..4645)
                     /locus_tag="FHS34_RS12295"
                     /old_locus_tag="FHS34_002496"
     CDS             complement(3878..4645)
                     /NRPS_PKS="Domain: PKS_KR (7-182). E-value: 2.5e-09. Score:
                     29.2. Matches aSDomain:
                     nrpspksdomains_FHS34_RS12295_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572678.1"
                     /locus_tag="FHS34_RS12295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002496"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_184964133.1"
                     /sec_met_domain="adh_short (E-value: 2.8e-31, bitscore:
                     104.5, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.4e-34, bitscore:
                     115.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVLTGKTALVTGGSRGIGRAVALRLAAAGALVAVHYGGNEQAAK
                     EVVGRIEEAGGRAFLIRARFGEAGAVDRLFEELTVGLAGAGLDILVNNAGISSGNPISQ
                     VTEEEFGRLMEINVATPFFVVQRAMALLNDAGRIINMGSTASRFAVSTQIGYTISKAAL
                     EAMAPSLANELGRRGITVNTVAPGAVRTDMTAGYTSIPEVVAGLESITALGRLGEPEDI
                     SDVVAFLAGPQGRWVTGQTIDVSGGTFLGPIAP"
     aSDomain        complement(4100..4624)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHS34_RS12295_PKS_KR.1"
                     /evalue="2.50E-09"
                     /label="FHS34_RS12295_PKS_KR.1"
                     /locus_tag="FHS34_RS12295"
                     /protein_end="182"
                     /protein_start="7"
                     /score="29.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TALVTGGSRGIGRAVALRLAAAGALVAVHYGGNEQAAKEVVGRIE
                     EAGGRAFLIRARFGEAGAVDRLFEELTVGLAGAGLDILVNNAGISSGNPISQVTEEEFG
                     RLMEINVATPFFVVQRAMALLNDAGRIINMGSTASRFAVSTQIGYTISKAALEAMAPSL
                     ANELGRRGITVN"
     CDS_motif       complement(4553..4618)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHS34_RS12295_0001"
                     /evalue="1.20E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="FHS34_RS12295"
                     /protein_end="31"
                     /protein_start="9"
                     /score="18.0"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAVALRLAAAGA"
     tRNA            complement(4873..4949)
                     /anticodon=(pos:complement(793711..793713),aa:Met,seq:cat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FHS34_RS12300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FHS34_002528"
                     /product="tRNA-Met"
     gene            complement(4873..4949)
                     /locus_tag="FHS34_RS12300"
                     /old_locus_tag="FHS34_002528"
     gene            complement(5086..5466)
                     /locus_tag="FHS34_RS12305"
                     /old_locus_tag="FHS34_002497"
     CDS             complement(5086..5466)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676850.1"
                     /locus_tag="FHS34_RS12305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002497"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_184964135.1"
                     /transl_table=11
                     /translation="MAAEQNHDSAACKRVDDGITRVFQLLGKRWSGPIVAVLVEQSAYF
                     ADLRRAIPGISERMLSDRLAELGAAGLVVREVDEGPPLRVSYRLTDAGAALEPALRELA
                     EWAKAHLPEAAACPETALERRA"
     gene            5616..6266
                     /locus_tag="FHS34_RS12310"
                     /old_locus_tag="FHS34_002498"
     CDS             5616..6266
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073540.1"
                     /locus_tag="FHS34_RS12310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002498"
                     /product="FMN-dependent NADH-azoreductase"
                     /protein_id="WP_184964137.1"
                     /transl_table=11
                     /translation="MATLLHIDSSVFPTEASASRAVAEAFRKQWEEQHPEGTVIHRDLA
                     AEPVAHITADAHLAGFVPESAHTPGQAAAFAERVKLIEELERADAILIGAPMYNFTIPS
                     TLKAWLDNVILMGRTAGETQSAKGTPVTVIASRGGSYAPGTPREGYEYVQNYLKAVLAD
                     ALGLDLEFIVPELTMASKNPAMADLVPLAEASHDRALEAAATRARRLAEHIAA"
     gene            6519..6800
                     /locus_tag="FHS34_RS12315"
                     /old_locus_tag="FHS34_002499"
     CDS             6519..6800
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676842.1"
                     /locus_tag="FHS34_RS12315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002499"
                     /product="hypothetical protein"
                     /protein_id="WP_184964139.1"
                     /transl_table=11
                     /translation="MNNPPSVNSYVDRVTAGPGGAMTDEAGVVTGDLIVATILRADGIS
                     VRVAVQHSGSETWYTLSGSPAPVPSGRLAAYHRDLLGRIRRGGGTRAT"
     misc_feature    complement(7066..7081)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.97"
                     /tool="antismash"
     misc_feature    7067..7080
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(7082..7097)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.79"
                     /tool="antismash"
     gene            7169..8917
                     /locus_tag="FHS34_RS12320"
                     /old_locus_tag="FHS34_002500"
     CDS             7169..8917
                     /GO_function="GO:0016798 - hydrolase activity, acting on
                     glycosyl bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141077.1"
                     /locus_tag="FHS34_RS12320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002500"
                     /product="carbohydrate binding domain-containing protein"
                     /protein_id="WP_184964141.1"
                     /transl_table=11
                     /translation="MRRPRSARALLTGVATLAAAAGLTLGAGSAAHAATPLPAHVFAPY
                     FEAYNGDSPAALAQASGAKYLTMAFLQTDRKGSCTPYWNGDTGTPVDASVFGSDFTTIR
                     ARGGDVIPSLGGYAADNGGTEMADSCANVDSIAAAYEKVITTYDVSRLDMDIEDNSLTN
                     TAGINRRNQAIKKVQDWAAANGRSVQISYTLPTTTTGLADSGLAVLRSAKNAGAKVDVV
                     NLMTFDYYDGATHHMATDTQTAASGLHDQLAGLYPNLSDTQLWNMIGVTEMPGVDDYGP
                     AETFTTADATAVYDWAVAKGINTLSFWALQRDNGGCPGSPASDTCSGIPQDTWYFTHTF
                     APFTGGTTTPPADDFSVSLSPATASVDPGGSATATVRTSVTAGSARTVDLAVSGAPGGV
                     TATLSPASVTAGGTATLTLKATAATAPGTYPLTVTGTAGATRHSASFTLTVNGPGGTAA
                     LANGDFETGSLAPWTCDNGAAVVSSPAHAGSHALKTAPSATQTGQCAQTLTLKPHTSYT
                     LSGWVQGPYAYLGVGGGATASTWASPSSWSKLTVPFTTGDSGTVTVYVHGWYGQGAVLA
                     DDLSVS"
     gene            9051..9932
                     /locus_tag="FHS34_RS12325"
                     /old_locus_tag="FHS34_002501"
     CDS             9051..9932
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676839.1"
                     /locus_tag="FHS34_RS12325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002501"
                     /product="DMT family transporter"
                     /protein_id="WP_184964143.1"
                     /transl_table=11
                     /translation="MIELAAVFAVAGAASNAVGTAFQRKAASDSKRGGLRLIAELVRRP
                     YWMIGMAGVICAALFQSLALVNGPLALVQPLFILELPFALLVAAPLMHRRLPRSGWWGV
                     AGCVAGLAVLLIAAAPHGATDQAPLVRWIPAVCLCAGAMAVAVLLAGRGRPPARRAALL
                     AAASAIGNALTAALLKSASGTFADHGFTAFLRSWQTYGFALAGTAAVLLLENALQAGPL
                     AAAQPALTIGDAVVSLTLGITLFDERIRTGWWLVPETCGALLIVAGVLVLSRAVQHIVV
                     LPVPAEGQNVAS"
     gene            complement(10001..11047)
                     /locus_tag="FHS34_RS12330"
                     /old_locus_tag="FHS34_002502"
     CDS             complement(10001..11047)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000172: Biaryl bond formation (75% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568017.1"
                     /locus_tag="FHS34_RS12330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002502"
                     /product="cytochrome P450"
                     /protein_id="WP_184964145.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 6.8e-189,
                     bitscore: 622.7, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 3.2e-13, bitscore: 44.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSSAAPARTTVFAPRLAALIGDHLGQDVFRLEPDTIGVAGHEV
                     ADRILAARRATETERPTFKPLHGRSISRTEASTVTRTIGNDVREALSGPLPRNVDLAGP
                     WPLTGHLFLRDLILGQDPYRLRMLMSRALELTPKLTWSVIAVGAALPGWPRPGARLTGL
                     ADRAARARGYQERRYAMGMYRRAAAPVCFTVSTLVANALWLGAPFDAGTSNRNIVLESL
                     RLLPPSWNVLRNASPEYPAVDGRIGERDDVLVLPLLSHRDPALWDAPDTFRPERWDSLD
                     PDTAPGYLPFGHSSERCWGRHMVMPLAELLLDLVRGSGLVVDPGQRAGRVPLLGLLGVE
                     EVRLTRSR"
     gene            complement(11171..11251)
                     /locus_tag="FHS34_RS44160"
     CDS             complement(11171..11251)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038372.1"
                     /locus_tag="FHS34_RS44160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tryptorubin family RiPP precursor"
                     /protein_id="WP_221508864.1"
                     /sec_met_domain="atropopeptide_precursor (E-value: 1.0,
                     bitscore: 1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLFAIRNRVAANKSLKANAWYLWY"
     misc_feature    complement(11269..11284)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(11668..12150)
                     /locus_tag="FHS34_RS12335"
                     /old_locus_tag="FHS34_002503"
     CDS             complement(11668..12150)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676838.1"
                     /locus_tag="FHS34_RS12335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002503"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_225817408.1"
                     /transl_table=11
                     /translation="MTSPVPAGATRRIFIDKQSPKAYHALVQTSEAVRAVAADAGLDRV
                     LVELVNLRVSQINGCASCLDVHTRAALRAGDTPRRLGVLAAWRDTELFTPAERAALALA
                     EATTAAADGAAQDVAHAAAREVLTDDQVAAVIWVAVTINAFNRVSIMSRHPVRAER"
     misc_feature    complement(12189..12202)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.28"
                     /tool="antismash"
     gene            complement(12210..13802)
                     /locus_tag="FHS34_RS12340"
                     /old_locus_tag="FHS34_002504"
     CDS             complement(12210..13802)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (122-285). E-value:
                     1.7e-15. Score: 49.3. Matches aSDomain:
                     nrpspksdomains_FHS34_RS12340_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017242049.1"
                     /locus_tag="FHS34_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002504"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_184964149.1"
                     /sec_met_domain="PF00561 (E-value: 5.6e-20, bitscore: 67.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTTSRDNGCRPRPGRPRRFTGRAAAAVVLSLAGALALGTAPAP
                     PAAARPATDPLARYHDQRLHWKSCLLGPDDTTGKELEQAGAQCADVTVPLDYARPDGRT
                     ISVAISRIRGTDTTHRAGALLLNSGGPGGQTIGDPPWVRSAMKDVAARYDVVGVDPRFV
                     GRSTPLDCHWPTGSMIRGAGTGRAAFGRMVAFSADLARRCRTHAGDLLPYATTRDTARD
                     MDVVRAALGERRISYLGYSYGSYLGQVYATMFPGRTDRVVLDGVVAPAGYGPRLLRGTE
                     EANRHALRDWADWTAAHAVAYGLGGTRSAVLAAVEAARSAAARTPLRVGGYRVDEHVLP
                     VIVFNGLSQDNPKAYGDFAEAVRDLRRAAGGRTVSPSPWLASTLKFVLTGDESVYGSAQ
                     TSILCGDVPASHDPETYWRDLRRAGTRDRLFAPVTKDINPCAFWGPPRERTTTIRDDLP
                     ALLVNATGDPRTTYRSARTVHHDWPSSRLVTLRGADQHGVYGVFGSPCVDSTVNAYLAT
                     GRLPSADVSCPAP"
     CDS_motif       complement(12504..12551)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHS34_RS12340_0001"
                     /evalue="2.20E-02"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="FHS34_RS12340"
                     /protein_end="433"
                     /protein_start="417"
                     /score="7.5"
                     /tool="antismash"
                     /translation="RDLRRAGTRDRLFAPV"
     aSDomain        complement(12948..13436)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHS34_RS12340_Abhydrolase_1.1"
                     /evalue="1.70E-15"
                     /label="FHS34_RS12340_Abhydrolase_1.1"
                     /locus_tag="FHS34_RS12340"
                     /protein_end="285"
                     /protein_start="122"
                     /score="49.3"
                     /tool="antismash"
                     /translation="ALLLNSGGPGGQTIGDPPWVRSAMKDVAARYDVVGVDPRFVGRST
                     PLDCHWPTGSMIRGAGTGRAAFGRMVAFSADLARRCRTHAGDLLPYATTRDTARDMDVV
                     RAALGERRISYLGYSYGSYLGQVYATMFPGRTDRVVLDGVVAPAGYGPRLLRGTEEANR
                     "
     gene            complement(13799..15004)
                     /locus_tag="FHS34_RS12345"
                     /old_locus_tag="FHS34_002505"
     CDS             complement(13799..15004)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005466.1"
                     /locus_tag="FHS34_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002505"
                     /product="serine hydrolase"
                     /protein_id="WP_225817371.1"
                     /transl_table=11
                     /translation="MAIPLRSTTLRRRTGLAAVAMACLLGAAPAAVAQSHRDASRPCGP
                     HPELSRSVHHLVAHDRFAGAAVLVTGPDPAAPCARWTVTDGVADLGTGRAMNATDRLRV
                     GSVTKTFTATVVLQLAAERRLSLDAPVERYLPGLIRAGGHDGRRITVRQLLQHTSGLPD
                     YLEAPEWEHPERVRYRHFEPRRLVARALRLPRPERAWHYATTNYLVAGLIVREVTGHSP
                     ESEITRRIIAPLGLRDTYWPGDDARIRGPHSHSYFTAADGRRADGTAWNTTFGGVGGAL
                     ISTPADLNRFTAALFSGRLLPAPQLAEMRRTVAADPDRLWPGARYGLGLISSPLSCGGS
                     WEGHAGTVPGGHRALAAVGPGGRRVAFVLNEVPATLQAELDFLDVVDKALCEGTSAERT
                     SA"
     misc_feature    complement(14990..14992)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14999..15009
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 20.07"
                     /tool="antismash"
     misc_feature    complement(15112..15126)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.07"
                     /tool="antismash"
     gene            15406..16170
                     /gene="uppS"
                     /locus_tag="FHS34_RS12350"
                     /old_locus_tag="FHS34_002506"
     CDS             15406..16170
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018847992.1"
                     /locus_tag="FHS34_RS12350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002506"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_184964341.1"
                     /transl_table=11
                     /translation="MFPDPARGRPRGEARRRVPRHVACVMDGNGRWAARRSLPRTSGHR
                     AAETTVIDVIEAARTAGVEWLSLYAFSTENWQRPGSEVDFLMRLVRRVVRKHAPVLHLR
                     GIRCRFLGVTDPRIPPALARDFADLMTLTGENRGMTLTVAFDHGGRGDIVAAARSLIRS
                     GVPAEAVDERSFAAHLPFPDTPDVDLVIRTSGEQRISNFMLWQVAYAEWIFPPVLWPDF
                     RAAHFLECLDTYRQRDRRFGGVTPNANGERRP"
     gene            16257..17666
                     /locus_tag="FHS34_RS12355"
                     /old_locus_tag="FHS34_002507"
     CDS             16257..17666
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019434065.1"
                     /locus_tag="FHS34_RS12355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002507"
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_221508866.1"
                     /transl_table=11
                     /translation="MFGPDSRFHAFFHDPRWALSIVRATVLEAAHPQVGAALTDNSTFV
                     AHPWRRLRNTVVSLQRMFGADDEVRRREAARLNRLHARLKGADAHDRPYDAMDPAVRGW
                     VVATLFESSVTMCRLSGQPLERGDMDRLYAEFRAYLAALEGDAGHLPPTVQEFWPYYDR
                     VVEEELENTEAMRVILYRLFDHLPAPPLLHGLPAMWAAGRAVAGPLIGVITVASLPEPF
                     RRRAGLPEMPGAQTLMQGAYLAAGLARFLPDGWIQPEGIAKLLALDPGGDDPRARSIGA
                     LTDRMKRAGALVRLLAPLPPEPDPAGGTDVRREAEAFFTAVLDQTGDGYLDWPDLAAMA
                     REVAGRLDLDEPDETRLYDAFAGWWRELQAALDTDGDGRVSVREYAEAVPSLAGPALIR
                     VAEVLFDVTDTDGDRRVDADEYRALFRRGFRRDMAGADGTYSRAAFVRDFLSFMAGRER
                     STAYDPLFSDA"
     gene            complement(17695..18567)
                     /locus_tag="FHS34_RS12360"
                     /old_locus_tag="FHS34_002508"
     CDS             complement(17695..18567)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980729.1"
                     /locus_tag="FHS34_RS12360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002508"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_184964153.1"
                     /transl_table=11
                     /translation="MPKPALRRVLTATSAAVGALILGLTTAPAQAGTPLNYAALGDSYS
                     AASGVLPVDLSSPLCLRSTANYPHVIASRTAARLTDVTCGAAQTKHFTEAQYPGVAPQA
                     DAVTADTDLVTLTIGGNDNGTFINAVTACGTAGVFSGGKGSPCKDKYGTAFDDQIDADT
                     YPALKAALRSVRAKAPRARVAVLGYPWITPATAEPSCFVTLPVATGDVPYLHSLQAHLN
                     TVVRRAAEETGTTYVDFSAVSAGHDACQPVGTRWIEPLLFGQNIVPVHPNALGERSMAE
                     HTLSVLGLG"
     misc_feature    18813..18826
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.8"
                     /tool="antismash"
     gene            18978..19133
                     /locus_tag="FHS34_RS12365"
                     /old_locus_tag="FHS34_002509"
     CDS             18978..19133
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676832.1"
                     /locus_tag="FHS34_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002509"
                     /product="DUF6131 family protein"
                     /protein_id="WP_184964155.1"
                     /transl_table=11
                     /translation="MIALGIILLIIGFVTGISILWTIGVILLVVGAVLWIMGSMGHAVA
                     GRRHYW"
     misc_feature    complement(18979..18994)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.92"
                     /tool="antismash"
     gene            complement(19200..20048)
                     /locus_tag="FHS34_RS12370"
                     /old_locus_tag="FHS34_002510"
     CDS             complement(19200..20048)
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-262). E-value:
                     7.7e-16. Score: 50.4. Matches aSDomain:
                     nrpspksdomains_FHS34_RS12370_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016473255.1"
                     /locus_tag="FHS34_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002510"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_184964157.1"
                     /sec_met_domain="PF00561 (E-value: 5e-09, bitscore: 31.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEIELSAGTIDYDDTGGDGPVVVLAHGLGFDGSVWAEVVARMRP
                     GFRVLVPVLPIGSHRRPMRPDADLSAHGIACLLAEFMERLDLRDVTLVQNDTGTAQLLV
                     GVRDERVARLVLTSCEALENYPPGVQGRLLHAASRVPGGLFLLLQSFRFPFLARMETSL
                     GGMAKKRLPKELIARWYGPVLTNRHIRRDLAKFCRATRKDCYLRAARNLPLFTRPALVA
                     WGAEDRMMPPETGRRLARLLPNARYVEIPDARTLVQWDNPAALTGEIRRFVAANPLAGE
                     G"
     aSDomain        complement(19263..19988)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHS34_RS12370_Abhydrolase_1.1"
                     /evalue="7.70E-16"
                     /label="FHS34_RS12370_Abhydrolase_1.1"
                     /locus_tag="FHS34_RS12370"
                     /protein_end="262"
                     /protein_start="20"
                     /score="50.4"
                     /tool="antismash"
                     /translation="PVVVLAHGLGFDGSVWAEVVARMRPGFRVLVPVLPIGSHRRPMRP
                     DADLSAHGIACLLAEFMERLDLRDVTLVQNDTGTAQLLVGVRDERVARLVLTSCEALEN
                     YPPGVQGRLLHAASRVPGGLFLLLQSFRFPFLARMETSLGGMAKKRLPKELIARWYGPV
                     LTNRHIRRDLAKFCRATRKDCYLRAARNLPLFTRPALVAWGAEDRMMPPETGRRLARLL
                     PNARYVEIPDARTLVQWDNP"
     misc_feature    complement(20172..20186)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.91"
                     /tool="antismash"
     gene            20180..20785
                     /locus_tag="FHS34_RS12375"
                     /old_locus_tag="FHS34_002511"
     CDS             20180..20785
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005307892.1"
                     /locus_tag="FHS34_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_002511"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_184964159.1"
                     /transl_table=11
                     /translation="MSKGRAPSTHETRQRILTAGTELFRRTGYTGTGMKQIAAAAGAPF
                     GSIYHFFPGGKAQLGEEVVRTSGAGYLELITALMTPYEDRVAATADAFDAAAGTLAELD
                     FADPCPIATVAMEVASTDETLRRATAEVFDSWTGRLAAYYAEGGIPEPAARETATSVIA
                     LLEGAFMLGRAARSTAPVLAAARAAAAIVRAALDAGRG"
ORIGIN
        1 tccacgagcc gctcgcgggc ctcttcggag cggaccagga ccacccgcag cggcggctgg
       61 tagtacgagc tcggacatca ggggtgctcc tgtcgttcag ccttgataat ctcaacgtta
      121 agataaaacc agtccgactc tctcaacgtc aagtgtctta acgttgagaa gatgtccatc
      181 gagaggagtg acggcgatga gcgatgccgt ggacgcgatc atcggccagt gggccgagga
      241 gcgccccgac gtggtggagg atctctggcc ggtacagctc ttcgggcgga tccagcggct
      301 ggcacgggtg gtcgacaagt ccgccagggc cgcggccgcc gcacacggcg tggagcacgg
      361 cgagttcgac gtgctcacta cgctgcagcg ctcagggccg ccctacacgc tcaccgccgg
      421 ggccttcgtc aaggcatcca tggtgacctc cggtgcgatc accaaccgca tcgacaagat
      481 ggaggccaag ggcctggtcg agcgggtacg ggatgacgac gaccggcgca ccatcaagat
      541 ccgcctcacc gaacacgggc acgagatcac ccgggccgcc ttcgccgacc atctggcgaa
      601 ctacgcacag ctgctcgccg acgtggaccg cggtgtggtc gacaagaccg cagaggggct
      661 ccgccgagtg ctggagagcc tcggcgacac caccatcaag tgacgacggc ccgacagacc
      721 ggggacgcac gcggtgagcc ggatgtgccg gccgccgtac cccgttcgcg acgcctgcgg
      781 tgcgcggcgt ccgactgggc caccacctcg gagatcggta ccttgaggtt cgtcatgcct
      841 cagaccttct acgggagcgc tcaccgcggg ctcacggcga gctcaccgcg ctcgccggct
      901 caccgcggtg gaatgacccg gctcaccggt ccgcggccac ggcctcgagg acgcacccca
      961 cggtcttctc ggacaacccc agcatgcgca gcacctccgg ggcgcgcgcc ccggccgtgt
     1021 cggcgacctc ggcggcctgc cggtagtgct cgcgcgcctt cgcgtggtgg ctccgggccg
     1081 cggccacccg gccgaggccg atgagcgtgc gcacccgggg gcccaggctc ttgatccagt
     1141 gcggatcgat ccgctccagc gcctcgctgt acagccgttc cgcctccgcc aggtcgccct
     1201 cctccagagc gatgtcgccg agcccgcgca gcgcggccgc caggtaggtg gaactgccgg
     1261 cgcggcgggc gagcgcggcg gcgttcgcat aggcggtacg agcccccgcc gcgtcgtccc
     1321 cggcgaggtg atcgcctcgg ttgaccagca ggtcggcgct gtcctccaag gcatcgagcc
     1381 gttcggtgag caccagggcc tcgtcggtga gcccgaccgc ccgtgtccgg tcaccgcgcg
     1441 cgccggccac gccggccagc gtgtccaggg ccagcgccat gccccagcgg tcgccgagcg
     1501 agcggaatcc ctccagggcc tggccgaagg cgacttcggc cgccgcggga tcccgccggc
     1561 cgaggtgccc gaaccccgag acgtaatggg cggcggcccg cgtccacggc tcgggacagt
     1621 cgcgctggga cgagaccagc gcgaatgcgt cctgcgggga cggtccgccc gcgttccgca
     1681 tcatccacag cagcacgacg accgggtagc ggcccgagcg gtcgccgggc cacgcggccg
     1741 ccagcgcttt gccggccgtc gcacggtgcc gctgccacat ccgttccccg gcgccatccg
     1801 tcgccgacgc cgctccggcg agcagcacgc atgtcgcgta ctcctcgccg agcccgtcgg
     1861 ggaccgcctc acccaccgaa gcgagcagtg cgatcgccag gggcgcgacc gacgcggacg
     1921 caccccggat ccagaggtag ttgaacgccg cggcgagcag ctcgaaggcg gtctgcacgg
     1981 ccggctcctc gaccgcccag cgcagcgccg ccagaagatc ctcgtgctcg gcggcgacca
     2041 cggccagcca ctccaactgc tcggcccgcc gcagatgcgg gtcggccgtc cgcacgagct
     2101 ccagcaggcg ctgggcgtgg gcgcgtcgca cggactcgcg ttcacccgcc gcgtcgagcc
     2161 gttcggcacc gtacgcgcgg atcgtctcca gcatccggta gcggccgccc gcgacctcca
     2221 gcagcgactt gtcggccaga gcctccagcg tctcagcgtc ggtgccgcag acccgaaccg
     2281 cggaccgggc cgtcgcgccc ccggcgaaga ccgtgaaccg ccgcgcggcc cgctgctcgg
     2341 gctcggagag caggtcccag ctccacgcga ccaccgagcg cagcgtgcgg tgccgctcgt
     2401 ccgccgtgcg gttgccgcgg gcgccgacgg cgaggaggtc gtccagcctc cccgccaggt
     2461 cgtcgatgtc cagggtgcgc gaccgcgccg ccgcgagctc gatggccagc ggcaggtcgt
     2521 cgagcgccgc gcagatgcgc cgtacgacct cggggtcggc ggtgaagccg cgccgcacgg
     2581 caccggcgcg ctcggtgaac agccgtacgg ccgcgtcctc gtcgagcggc cgcacggggt
     2641 agaggtgctc gccgatgatg ccgagcggct cccggctcgt cgccagcacg cgcagccgcg
     2701 ggcaggccgc cagcagccgc gccgccagcc cggcgacctc gtcgacaagg tgctcgcagt
     2761 tgtccaggac gagcaggagc acctggtcgg acagcgccgc gatcagacga tcgaccggtg
     2821 ccgtcgcgcc gccgcccatc tggagcccgt tctcacgcag gccgagcgcg cccagcaggg
     2881 catgcggcag gccggcgccg tcgcgcagcg gtgccagctc cacgaagcac acctggcccg
     2941 cgacgtccgc ggcacccgcg acctcgaccg acagccgggt cttgccgacg ccgcccggcc
     3001 cgaggagggt gaccagccga gccacccgca acgcctcggc gacctcggtc acctcatcgg
     3061 cgcgcccgac gaaattcgtc agctgcgcgg gcggcgctgc cggcgacgcc gtcggatcgg
     3121 tgctcagcag ttcccggtgc agcgccgtca gttcggccga gggatcggcg ccgagctcgt
     3181 cggccaggtg ccgccgggtc gcctcgaaca ccaccagcgc ctcggcctgc ccgccttcgg
     3241 cgaacagcgc ccgcatcagc agccccgcca gccgttcacg cagtggatgg cggccgacca
     3301 gctcgcgcag ttcgggtacg accgccctgt gctcgccgag ccgcagctcc gcttcgatgc
     3361 ggtcttcgag tgccacgagc cgacgttctt ccaggcgcac ggcgacggcc tgagccgtct
     3421 cgctctcggg caggtcggcc agcaccggtc cccgccacag ctccagcgcc tcgtgcagca
     3481 gcacgaccgc ccgtccggcc tcgccgtcgg cgagcgccgc acggccctcc ccggccaggc
     3541 gctcgaaacg gaaggcgtcc acatcgtccg gatcgatcac gatccggtac cccgcaccgg
     3601 cccgttcgat cgcggctgcg gcgcccagtg cggtacggag cctggacacc tgggactgca
     3661 gcgaatgcgc cgaaagcgcc ccggtggggg cgatctcgtc agccagccgg tccgtcgaca
     3721 cgacctctcc ggggcgcacc agcagcaggg ccagcaacgc ccgtcgggcc ggtccgccca
     3781 acgggacttc gtcgtcgtcg tgccatgctc gcgtctcgcc gaggattccg aaccgcatgc
     3841 cggagattat tcaccggcac gcaggatcca cgaaggatca tggagcgatc gggccgagaa
     3901 aggtcccgcc cgacacgtcg atggtctgac cggtcaccca gcggccctgt ggaccggcca
     3961 ggaacgcgac gacgtccgag atgtcctccg gctcgcccaa tcgccccagc gcggtgatcg
     4021 actccagccc ggccaccacc tcggggatgg aggtgtagcc cgcggtcatg tcggtccgca
     4081 cggcgcccgg cgcgaccgtg ttcacggtga tgccgcggcg gccgagttcg ttggccagcg
     4141 acggtgccat cgcctccagc gccgccttgc tgatcgtgta gccgatctgc gtggagaccg
     4201 cgaaccggct ggccgtggag cccatgttga tgatgcgtcc ggcgtcgttc agcagtgcca
     4261 tcgcgcgctg gaccacgaag aacggggtag ctacgttgat ctccatcagc ctgccgaact
     4321 cctcctcggt gacctgcgag atcgggttgc ccgagctgat gcccgcgttg ttgaccagga
     4381 tgtcaaggcc ggctcccgcc agccccacgg tcagttcctc gaacagccgg tccaccgcgc
     4441 cggcctcgcc gaaccgggcc cggatcagga acgcccggcc gcccgcttcc tcgatccgcc
     4501 ccacgacctc cttggccgcc tgctcgttgc cgccgtagtg gacggcgacc agcgcgcccg
     4561 cggccgccag ccgcagcgcg acggcccggc cgattccccg cgaaccgccg gtcaccagtg
     4621 ccgtcttgcc ggtcagaacg ttcatcgtcg ccccctgtcg catggccggt ccgcggcgga
     4681 tccggcgatg accccacagt cgcggcgagg gctcaccggg agctcaccgc gggctcaccg
     4741 ggccacgccg gcgccagtct ccgcctccgc ttctggcagg gaaggggcgt cacgcgcccg
     4801 ccggtggcgg ctgctcgatg tcggcaggct ggggggacgc agaaggggcc cgcgtctgcg
     4861 ggccccttct tctggtagcg gggacaggat ttgaacctgc gacctctggg ttatgagccc
     4921 agcgagctac cgagctgctc caccccgcgt cgttgatgcc actctacacg ctggacagcg
     4981 ggcctccggc cggccgtcag ccaccgccgg cgacgaaggc gtctgtcagg tggtgcctcg
     5041 gcccgcttcg acgccgcgga cccgggccga tcctgacgaa gccctctagg cccgtcgctc
     5101 cagggccgtc tcggggcatg cggccgcctc cggcagatgg gccttcgccc actccgcgag
     5161 ttcacggagc gcgggctcca gggcggcgcc ggcatcggtc agccggtagg agacgcgcag
     5221 cggggggcct tcgtcgacct cgcgcacgac gaggccggcg gcgccgagtt cggcgagccg
     5281 gtcggacagc atgcgttcgc tgatcccggg gatcgcgcgc cggaggtcgg cgaagtacgc
     5341 ggactgctcc accaggacgg ccacgatcgg gccgctccag cgcttgccga gcagttggaa
     5401 gacacgggtg atgccgtcgt ccaccctctt gcacgccgca ctgtcgtgat tctgctccgc
     5461 cgccatggca tcagggtact actccgccgt agggggctga aaaaaagtaa gtccgtgtgc
     5521 taaaagtagt ccagtacgaa aagtgagcca gggcgcctcg gcgtccggcc gcgtacaccc
     5581 ctcatcgctt cgcacagccc cttacggaga cccccatggc caccctgctg cacatcgatt
     5641 cgtccgtttt cccgaccgag gcctcggcct cccgcgccgt ggcggaggcc ttccgcaagc
     5701 agtgggagga gcagcacccc gagggcaccg tcatccaccg tgacctcgcg gccgagcccg
     5761 ttgcgcatat caccgccgac gcgcacctcg ccggtttcgt ccccgagtcc gcccacacgc
     5821 ccgggcaggc cgccgccttc gccgagcgcg tcaagctgat cgaggagctg gagcgggccg
     5881 acgcgatcct gatcggcgcc cccatgtaca acttcacgat cccgtcgacc ctcaaggcct
     5941 ggctggacaa cgtgatcctc atgggccgca cggcgggcga gacccagtcc gccaagggca
     6001 cccccgtgac cgtcatcgcc agccggggcg gctcctacgc gccgggcact ccccgtgagg
     6061 gctacgagta cgtgcagaac tacctcaagg ccgtcctcgc cgacgcgctc ggcctggacc
     6121 tggagttcat cgtcccggaa ctgaccatgg cgtcgaagaa cccggcgatg gccgacctgg
     6181 tcccgctggc cgaggcctcc cacgaccgcg ccctcgaagc cgcggccacc agggcacggc
     6241 ggctcgcgga gcacatcgcg gcctgaccgc cggcatcgag ccgggtggcg ggcggtcacc
     6301 gggccgcccg ccggtcacgc ggcggaccgg ctcccgcgcc cccgcgcggc gcggtcgccg
     6361 ccccgcccgc ccgcctgccc gtccgtcagc cggtggaccg gttcccgtgc ccggcgcggg
     6421 ccgccggccc ccggccgcac gcccgacacg gggacacggg cgtgcgacac ccgcgcggtg
     6481 cggggcgcgc cggacagggt gatggaaacc tgcgccccat gaacaaccca cccagcgtca
     6541 acagctatgt cgaccgtgtc acggccggtc ccggcggggc gatgaccgac gaggccggcg
     6601 tcgtcaccgg cgacctcatc gtcgcgacca tcctgcgtgc ggacggcatc agcgtgcgcg
     6661 tcgccgtcca gcactccggc agcgagacct ggtacaccct ctccggcagc cccgccccgg
     6721 tgccgtcggg ccggctcgcg gcctaccacc gcgatctgct cggccgcatc cggcggggcg
     6781 gcggaacgcg cgccacctga gccgggcccg gcgggacggg ccgccggcgg ggctcccgcc
     6841 accacacatc tcggcgtcgc cggcgtgccc tcatgaggtg gcccagcaag ccctcaccgc
     6901 gggcaggccg gcagccaccg ggcgcgggcc cgaagtgcga agcctcaccc cggccatgac
     6961 gcgacgtcag gaccgcgccc tccggtcgga cacggccgat ccccacgacg gacacggccg
     7021 attcccatga acgtgcaaaa gccgttcccc acaccttgac cgtcatttgg tccagaccaa
     7081 ttatggccta gaccaatagc cccggccggg ccgcacagcg cgacaacccc gtttctctcg
     7141 cctgtcgttc gctatccggg agtacccgat gagacgtccg agatccgccc gcgccctgct
     7201 caccggcgtg gccacgctgg ccgcggccgc cgggctcacc ctgggggccg ggagcgccgc
     7261 gcacgccgcg accccgctgc ccgcccacgt cttcgccccc tacttcgagg cctacaacgg
     7321 cgacagcccc gccgcactcg cccaggcctc cggcgccaag tacctgacca tggccttcct
     7381 gcagaccgac cggaagggct cgtgcacccc gtactggaac ggggacaccg gcaccccggt
     7441 cgacgcctcg gtcttcggct ccgacttcac caccatccgc gcccgcggcg gtgacgtgat
     7501 cccctccctc ggcggatacg cggccgacaa cggcggcacc gagatggccg acagctgtgc
     7561 gaacgtggac tccatcgccg ccgcctacga gaaggtcatc accacctacg acgtctcacg
     7621 cctcgacatg gacatcgagg acaactccct cacgaacacg gccggcatca accggcgcaa
     7681 ccaggccatc aagaaggtcc aggactgggc cgccgccaac gggcgctccg tgcagatctc
     7741 gtacaccctc ccgaccacga ccacgggact cgccgacagc ggactcgccg tgctgcgcag
     7801 cgccaagaac gcgggcgcca aggtggacgt cgtcaacctg atgacgttcg actactacga
     7861 cggcgccacc caccacatgg ccaccgacac ccagacggcc gcgagcgggc tgcacgacca
     7921 gctcgccggg ctgtacccga acctgtcgga cacccagctg tggaacatga tcggcgtcac
     7981 cgagatgccc ggcgtggacg actacggccc ggcggagacc ttcaccaccg ccgacgccac
     8041 ggccgtgtac gactgggcgg tcgccaaggg catcaacacc ctgtccttct gggcgctcca
     8101 gcgcgacaac ggcggctgcc ccggctcccc cgcctccgac acctgctccg gcatccccca
     8161 ggacacctgg tacttcacgc acaccttcgc gcccttcacc ggtggtacga cgacaccgcc
     8221 ggccgacgac ttctccgtct ccctctcccc cgccaccgcc tcggtcgacc ccggcggctc
     8281 ggcgacggcg acggtccgga cctcggtgac cgcggggagc gcccggaccg tcgacctggc
     8341 ggtgagcggc gcgccgggcg gggtgaccgc gaccctgagc ccggcctcgg tcaccgcggg
     8401 cggcaccgcc acgctgacgc tgaaggccac cgccgccacg gcacccggca cctatccgct
     8461 gaccgtcacc ggcacggcgg gcgcgacccg gcacagcgcc tcgttcaccc tgaccgtgaa
     8521 cggaccgggc ggaaccgccg cgctcgccaa cggtgacttc gagaccggct cactggctcc
     8581 gtggacctgt gacaacggcg cggcggtggt gtcctcgccg gcgcacgccg gcagccacgc
     8641 gctgaagacc gcgccgtccg ccacgcagac cgggcagtgc gcccagaccc tcaccctgaa
     8701 gccccacacg tcgtacacgc tgagcggctg ggtgcaggga ccgtacgcct acctcggggt
     8761 cggtggcggc gcgacggcga gcacctgggc ctccccctcg tcgtggtcga aactgacggt
     8821 gccgttcacc accggtgact cgggcacggt caccgtgtac gtccacggct ggtacggcca
     8881 gggcgccgtc ctcgcggacg acctgtccgt ctcctgatcc actcccgccc gccggcctcg
     8941 ccccggctca ccggggcggc gccggccgca cggcgcggcg gcgccgcctt ccgtaggctg
     9001 aagaagcccg atcctccctc cgggaggcca gccgcaggcg ggagacggtc gtgatcgaac
     9061 tggccgcggt gttcgccgtc gcgggagcgg cgagcaacgc cgtgggcacc gcgttccagc
     9121 gcaaggctgc ctcggacagc aagcgcggcg ggctccgcct gatcgcggag ctggtgcgcc
     9181 ggccctactg gatgatcggc atggccggcg tgatctgcgc cgcgctgttc cagagtctcg
     9241 ccctggtcaa cggcccgctc gcgctggtcc agccgctgtt catcctggaa cttcccttcg
     9301 cgctgctcgt cgccgccccg ctgatgcacc ggcggctgcc gcgctcgggc tggtgggggg
     9361 tcgccggctg tgtggcgggg ctcgccgtcc tgctgatcgc ggccgccccg cacggcgcga
     9421 ccgaccaggc accgctcgtc cggtggatcc cggctgtgtg cctgtgtgcc ggtgcgatgg
     9481 cggtggcggt actgctggcc ggccgggggc gcccgccggc ccggcgcgcg gccctgctgg
     9541 cggccgcctc cgcgatcggc aacgccctga ccgccgcgct gctgaagtcg gccagtggga
     9601 cgttcgccga ccacggcttc accgcgttcc tgcggtcctg gcagacatac ggcttcgcgc
     9661 tggccggcac ggccgccgtg ctcctgctgg agaacgcgct gcaggccggt cccctggcag
     9721 cggcccagcc cgcgctgacc atcggtgacg cggtggtgag cctcaccctc ggcatcaccc
     9781 tcttcgacga gcggatccgc accgggtggt ggctcgtacc cgagacgtgc ggtgccctgc
     9841 tgatcgtggc gggggtgctg gtcctcagcc gggccgtcca gcacatcgtc gtgctccccg
     9901 tcccggccga ggggcagaat gtggcctcgt gaggccgctc gggggcggcg accagcggcg
     9961 cgcgaggtgg ccggcggcac gggcccccgg gccggcgccg tcagcgcgac cgggtcagcc
    10021 gcacctcctc cacgcccagc agcccgagca gcgggacccg gccggcccgc tgaccggggt
    10081 cgaccaccag gccggagccg cggacgaggt cgagcagcag ctcggccagc ggcatgacca
    10141 tgtgccggcc ccagcagcgc tccgacgagt ggccgaaggg cagatagccc ggggcggtgt
    10201 ccgggtcgag gctgtcccag cgctccgggc ggaaggtgtc cggggcgtcc cagagcgcgg
    10261 ggtcccggtg ggacagcagc ggcagcacca ggacgtcgtc ccgctcgccg atccggccgt
    10321 cgacggccgg gtactcgggc gacgcgttgc gcagcacgtt ccacgagggc ggcagcagcc
    10381 gcagggactc caggacgatg ttccggttgg atgtgccggc gtcgaacggg gcgcccagcc
    10441 agagggcgtt ggccaccagg gtggacacgg tgaagcacac gggggccgcg gctctgcggt
    10501 acatgcccat ggcgtagcgc cgttcctggt acccgcgtgc ccgcgccgcg cggtccgcga
    10561 gtccggtgag ccgggcgccg ggccggggcc agccgggcag cgcggcaccg acggcgatca
    10621 cggaccaggt cagcttgggt gtgagttcca gggcgcggct catcagcatg cgcagccggt
    10681 aggggtcctg gccgaggatg agatcgcgca ggaagaggtg cccggtcagc ggccagggcc
    10741 cggcgaggtc cacgttccgg ggcaggggcc cggacagggc ctcgcgcacg tcgttgccga
    10801 tggtgcgggt gaccgtagag gcctcggtac ggctgatgga ccgcccgtgc agcggcttga
    10861 aggtggggcg ctcggtctcg gtcgcccggc gcgcggccag gatgcggtcg gcgacctcgt
    10921 gtcccgcgac cccgatggtg tcgggttcga gccggaagac gtcctggccc aggtggtcgc
    10981 cgatgagcgc ggcgagccgc ggggcgaaca cggtggtacg cgcgggcgcg gcggaagacg
    11041 gcggcatggc tcctccggta cggggacggg gcggggaggg cgaccgcggc acggcgggac
    11101 accgctgccc gtccggaccg cggcgcggac ggacaacgat gtcaccgtgg gtgcgcgcgg
    11161 cggcgccgga tcagtaccag aggtaccagg cgttggcctt gaggctcttg ttggcggcaa
    11221 ccctgttacg gatggcgaaa agaagcttca tcactgcacc tcccctcggg gacggacggg
    11281 tgacacgcgt cggctccggc ggaggaccgg tgaagatcgc gtgtcggcga cccccggaac
    11341 cttcccgcga tggttcaccg cttaatcgcc gaggcggtca aagacgttgc cacgcagtcg
    11401 atttcggact ttcggcgatc atcggcgatc cggtttgacc cgtcggcccg gcatgcgccc
    11461 accgcaccgc cgccgggacc cgagccacag gtggcagccg tgccgaccgc ccggataccg
    11521 gacggccggt cgtccggagc ggacgcgccc cgcaccgcac ccggccgttc cccggccggg
    11581 gaacggccgg agattggccg gatgctcacg cgcgggcagc gcccgggcgt ctacggcatc
    11641 gcgcccccgg agacacccgg cactgtgtca ccgctcggcc cgcaccggat gccggctcat
    11701 gatcgagacc cggttgaacg cgttgatggt gacggcgacc cagatcaccg cggccacctg
    11761 atcgtcggtg agcacctccc gcgccgcggc gtgggcgacg tcctgtgcgg cgccgtcggc
    11821 cgcggcggtc gtcgcctcgg ccagggccag ggcggcccgt tcggcggggg tgaacagctc
    11881 ggtgtcgcgc caggcggcca gcaccccgag gcgccgcgga gtgtcgcccg cccgcagcgc
    11941 ggcccgggtg tgcacgtcca ggcaggaggc gcagccgttg atctgcgaga cgcggaggtt
    12001 gaccagctcg accaggacgc ggtccagccc ggcgtcggcg gcgaccgcgc ggaccgcctc
    12061 ggacgtctgc accagggcgt ggtacgcctt cgggctctgc ttgtcgatga agatccgccg
    12121 ggtggcgccg gccgggacgg gactggtcag ctcggactcg ctggtcaaga cggactcctc
    12181 cggactcatc tttgttgaag atgaaactat cacggagcgg ggcagctgac gtccgccgag
    12241 ggcagccggc cagtggcgag ataggcgttg accgtggagt ccacgcacgg gctgccgaag
    12301 acgccgtaga ccccgtgctg gtccgctccc cgcagcgtca ccagacggga actcggccag
    12361 tcgtggtgta ccgtccgggc actgcggtag gtggtgcgcg ggtcgccggt ggcgttcacg
    12421 agcagggccg gcagatcgtc ccggatcgtg gtcgtgcgtt cgcgcggcgg gccccagaac
    12481 gcgcaggggt tgatgtcttt cgtgaccggg gcgaacaacc ggtcccgggt gccggcgcgc
    12541 cgcagatccc gccagtacgt ctccgggtcg tgcgacgcgg gaacgtcccc gcacaggatg
    12601 gacgtctgcg cgctgccgta gacggactcg tcgccggtca gcacgaactt cagggtcgag
    12661 gccagccacg gggacggcga gaccgtccgg cccccggcgg cgcgccgcag gtcgcgcacg
    12721 gcctcggcga agtcgccgta ggccttgggg ttgtcctgcg agagcccgtt gaagacgatg
    12781 acaggcagga cgtgttcgtc cacgcggtag ccgccgacac gcagcggggt gcgggcggcg
    12841 gccgaccggg cggcttcgac ggccgccagc acggcgctcc gggtgccgcc gagcccgtag
    12901 gccacggcgt gcgcggcggt ccagtcggcc cagtcgcgca gggcgtgccg gttggcctcc
    12961 tcggtgcccc gcagcagccg gggaccgtag ccggcgggtg ccaccacgcc gtccaggacg
    13021 acccggtcgg tgcgcccggg gaacatcgtc gcgtacacct ggccgagata actgccgtag
    13081 gagtagccca ggtaggagat ccggcgttcg cccagcgccg cacggaccac gtccatgtcg
    13141 cgcgcggtgt cgcgggtggt cgcgtacggc agcaggtcac cggcgtgggt acggcagcgg
    13201 cgggcgaggt ccgcggagaa ggcgaccatg cggccgaagg cggcgcggcc ggtgccggcc
    13261 ccgcggatca tgcttccggt gggccagtgg cagtccagcg gggtgctccg gccgacgaac
    13321 cgggggtcca cgcccaccac gtcgtagcgg gcggcgacgt ccttcatggc gctgcgcacc
    13381 cagggcggat cgccgatcgt ctgcccgccg gggccaccgc tgttgagcag cagcgcgcct
    13441 gcccggtggg tggtgtcggt gccccggatc cgcgagatcg ccacgctgat cgtgcggccg
    13501 tcgggacggg cgtagtccaa cgggacggtg acgtccgcgc attgggcccc ggcctgttcg
    13561 agctccttgc cggtggtgtc gtcggggccg agcagacagc tcttccagtg cagccgctgg
    13621 tcgtggtagc gggcgagggg gtcggtggcc gggcgggccg cggcgggcgg ggcgggggcg
    13681 gtgcccagag ccagtgcgcc cgccagggac aggacgacgg ccgccgcggc ccgcccggtg
    13741 aagcggcgcg gacggccggg gcgcggacgg cacccgttgt cccgggaggt ggtactggtc
    13801 atgcggatgt cctttcggcg gacgtgccct cgcagagggc cttgtcgacg acgtcgagga
    13861 agtccagttc ggcctggagc gtggcgggca cctcgttcag gacgaaggcc acgcggcggc
    13921 cgcccggacc gacggcggcc agcgcccggt gcccgccggg cacggtcccg gcgtggccct
    13981 cccagctgcc gccgcacgac agtggtgagg agatcaggcc gagcccgtag cgggcgccgg
    14041 gccagagccg gtcggggtcc gcggccaccg tccgccgcat ctcggcgagt tgcggtgcgg
    14101 gcagcagccg cccggagaag agggcggcgg tgaaccggtt caggtcggcc ggagtggaga
    14161 tcagggcgcc gccgacaccg ccgaaggtcg tgttccaggc ggtgccgtcc gcacggcggc
    14221 cgtcggccgc ggtgaagtag ctgtgcgaat gcgggccccg gatgcgggcg tcgtcaccgg
    14281 gccagtacgt gtcgcgcagg cccagcggcg cgatgatgcg acgggtgatc tccgactcgg
    14341 ggctgtggcc ggtgacctcg cggacgatca gcccggcgac gaggtagttg gtggtcgcgt
    14401 agtgccaggc gcgctccggg cgcggcagcc gcagggcgcg ggcgacgagc cggcgcggct
    14461 cgaagtggcg gtaccgcacc cgttcggggt gctcccactc cggggcttcg aggtagtccg
    14521 ggagcccgct ggtgtgctgg aggagctgtc gtacggtgat ccggcggccg tcgtgtccgc
    14581 cggcgcggat caggcccggc aggtaacgct cgacgggcgc gtccagggac agccgccgct
    14641 cggcggcgag ttgcaggacg accgtcgcgg tgaaggtctt ggtgacgctg ccgacgcgca
    14701 gccggtcggt ggcgttcatg gcccggccgg tgccgagatc ggccacgccg tcggtcaccg
    14761 tccagcgggc gcagggggcg gccgggtcgg ggccggtgac caggaccgcg gcgccggcga
    14821 accggtcgtg cgccacgagg tggtgcacgg accggctcag ctccggatgc gggccgcacg
    14881 ggcgggacgc gtcccggtgc gactgcgcga cggcggccgg ggcggcgccg agcagacagg
    14941 ccatggccac ggcggcgagg ccggtgcgtc gtcgaagtgt cgtactgcgt aaggggattg
    15001 ccatgtgaca gcacgctagg gatctttcgg ggcgtactca ttccggctgg caggcgattc
    15061 ggtacggggg tcagcaccag cgcgcggggg gaggcaggcc cccgggcccg ccgggccgga
    15121 cggcccggga acggtcggac ggccccggca agaccggcct cggacgacca ccaacgggtg
    15181 ctccgatgcg cgggtttgcc gtgcggcccg gcggctgatc gccccctcac acagcagtgc
    15241 caagggtgaa ccgcgggcgt tacggcgtct cccggtccgg ggactgacac gctgctggag
    15301 acgatccggc ccctcacccg ggagagggcc gtgaggcggc ggacggtccg cccgtcgccg
    15361 ctggggggca gtgtgacggc cgaggaagtc atcgacggtt ccgccgtgtt ccccgatccg
    15421 gcccggggcc ggccgcgggg cgaggcacgc cggagggtcc cccggcacgt cgcctgcgtg
    15481 atggacggca acggccgctg ggcggcacgc cggtcgctgc cccgtacgtc gggtcaccgc
    15541 gcggcggaga cgacggtgat cgacgtcatc gaggcggcgc ggacggccgg cgtggaatgg
    15601 ctgagcctgt acgcgttctc cacggagaac tggcaacggc cgggcagcga ggtcgacttc
    15661 ctcatgcgac tggtccgccg cgtggtgcgc aaacacgcac ccgtgctgca cctgcgcgga
    15721 atccgctgcc gcttcctcgg agtgacggat ccacgcatcc ctccggcgct ggcccgggac
    15781 ttcgccgacc tgatgacgct gaccggtgag aaccggggca tgacgctgac cgtggcgttc
    15841 gatcacggcg gacgcggcga catcgtggcg gcggcacggt cgctgatccg cagcggagtg
    15901 ccggccgagg ccgtggacga gcggagcttc gccgcccatc tgccctttcc cgacacaccc
    15961 gatgtggacc tcgtcatccg cacctccggg gaacagcgca tctccaactt catgctgtgg
    16021 caggtcgcct acgcggaatg gatcttcccg ccggtcctct ggcccgactt ccgcgcggct
    16081 cacttcctgg agtgcctgga cacctatcga cagcgcgatc gccgcttcgg cggcgtgacc
    16141 ccgaacgcga acggagaacg acgaccgtga ccgacacagg cagcgacgga cccgccggca
    16201 ccggtgccga ccacagcgac cggcgccccg ggcagccggc acacgacgag gcacccctgt
    16261 tcggtccgga cagccggttc cacgcgttct tccacgatcc gcgctgggcc ctgtccatcg
    16321 tccgggcgac cgtgctggag gccgcgcacc cgcaggtcgg cgcggcgctg accgacaact
    16381 cgacgttcgt ggcccatccg tggcgccggc tgcgcaacac ggtcgtgagc ctgcagcgca
    16441 tgttcggcgc ggacgacgag gtccggcgca gggaggccgc ccggctcaac cggctgcacg
    16501 cacggctgaa gggtgccgac gcgcacgacc ggccgtacga cgcgatggat cccgcggtgc
    16561 ggggctgggt ggtggcgacc ctcttcgaga gcagcgtcac gatgtgccgg ctcagtgggc
    16621 agccgctgga gcggggtgac atggatcggc tgtacgcgga gttccgggcc tatctggcgg
    16681 ctctggaggg ggacgccggt catctgccgc ccacagtgca ggagttctgg ccctactacg
    16741 accgggtggt cgaggaggag ctggagaaca ccgaggcgat gcgcgtcatc ctgtaccggc
    16801 tcttcgacca tctcccggcg ccgccgctgc tgcacggcct gcccgccatg tgggcggccg
    16861 gccgcgcggt cgccggtccc ctcatcggtg tgatcaccgt ggcgtcgctt ccggagccct
    16921 tccgccgccg ggcgggtctg cccgagatgc ccggcgccca gaccctgatg cagggcgcct
    16981 atctggccgc gggcctcgcc cgcttcctcc cggacggctg gatccagccc gagggcatcg
    17041 cgaagctcct cgccctcgat cccggcggcg acgacccccg ggcccggtcg atcggcgcgc
    17101 tgaccgaccg tatgaagcgg gcgggggccc tggtccggct gctcgcaccc cttccgccgg
    17161 agccggaccc cgccggggga accgatgtgc ggcgcgaagc cgaggcgttc ttcacggcgg
    17221 tgctggacca gaccggggac ggctatctgg actggcccga cctcgccgcc atggcccggg
    17281 aggtcgccgg ccgtctcgac ctggacgagc cggacgagac gcggctctac gacgccttcg
    17341 ccggctggtg gcgggagctc caggcggctc tcgacaccga cggcgacggc cgcgtcagcg
    17401 tccgggagta cgccgaggcc gtgccgtcgc tcgccggccc cgccctgatc cgggtcgccg
    17461 aggtgctctt cgacgtcacc gacacggacg gcgaccggcg cgtcgacgcg gacgagtacc
    17521 gggcgctgtt ccgccggggt ttccgcaggg acatggccgg cgccgacggc acgtactcgc
    17581 gtgccgcgtt cgtgcgggac ttcctgtcgt tcatggcggg ccgtgagcgc tccaccgcct
    17641 acgacccgct gttctccgac gcgtgacccg cggtccggac ggggcggggc ccggtcagcc
    17701 gaggccgagg acgctcaggg tgtgttcggc catgctccgc tcgccgaggg cgttcgggtg
    17761 gaccgggacg atgttctgcc cgaacaggag cggctcgatc caccgggtgc cgacgggctg
    17821 acacgcgtcg tgtccggcgg agaccgcgga gaagtcgacg tacgtcgtgc ccgtctcctc
    17881 ggcggcgcgc cgcaccacgg tgttgaggtg tgcctggagg gagtgcaggt acggcacgtc
    17941 accggtggcg acgggcaggg tgacgaagca ggacggctcg gccgtggcgg gcgtgatcca
    18001 cgggtagccg agcaccgcca cccgggcccg gggggccttg gcgcggacgc tgcggagcgc
    18061 ggccttcagc gccgggtagg tgtcggcgtc gatctggtcg tcgaaggccg ttccgtactt
    18121 gtccttgcag gggctgccct tgccgccgct gaagacgccc gcggtgccgc aggcggtcac
    18181 ggcgttgatg aaggtgccgt tgtcgttgcc gccgatcgtc agggtcacca ggtcggtgtc
    18241 cgcggtgacc gcgtcggcct ggggggcgac gccggggtac tgggcctcgg tgaagtgctt
    18301 ggtctgggcg gcaccgcagg tgacgtccgt cagccgtgcc gccgtgcggg aggcgatgac
    18361 gtgggggtag ttcgccgtgg aacgcagaca caggggactg ctgaggtcga cggggaggac
    18421 accggaggcg gcgctgtaac tgtcccccag cgcggcgtag ttcagggggg tgccggcctg
    18481 ggcgggggcg gtggtgaggc cgaggatcag cgcgccgacg gccgcggacg tcgcggtgag
    18541 gacacggcgc agggcaggct tgggcatggc tctcccttct cgggacgggg caggggacgg
    18601 aaaacgggca tggcggtgcc acgggagtgc tggatcacga gagcggggcg gctcgaccgc
    18661 gcgaggacgt gcgaggacgt gcgaggacgt gcgaggacgg tccggggtgc gagaacggtg
    18721 cgcgaggggc gtgcgagccg gcggggcgtg gcagtgagcg cacgtacgac ggcgacgaga
    18781 gaccggccgc gggattaccg ggcggttcta ccgataagta atgtgaggcc gccgacatag
    18841 cgcgtcaaca ttgtggaccg aacttcttga aacacggacc gtcatgatcc gcgaagtttt
    18901 tccccttccg gatgcaattc cggccacgtt tggggcaccc gaaggacagg agcaccacta
    18961 cccgctggag gcacgccatg atcgccctcg gcatcatcct gctcatcatc ggcttcgtca
    19021 caggcatctc gatcctgtgg accatcggcg tgatcctgct ggtggtggga gccgtcctgt
    19081 ggatcatggg gtccatgggg cacgcggtcg ccggccgacg ccactattgg tgaggcggca
    19141 gccgcgacga ccggtcccct cccggcacac ccgcccgcgg gccgccggga ggggccgttt
    19201 cagccttcgc cggccagcgg gttcgccgcg acgaagcgcc ggatctcccc cgtcagggcg
    19261 gccggattgt cccactggac cagcgtcctg gcgtcgggga tctccacata gcgcgcgttc
    19321 ggcagcagcc gggccaggcg gcggccggtc tcgggcggca tcatgcggtc ctcggcaccc
    19381 caggcgacca gcgccgggcg ggtgaacaac ggcaggttcc gcgccgctcg cagatagcag
    19441 tccttccgcg tggcacggca gaacttggcc aggtcccggc gaatgtgccg gttcgtcagc
    19501 acagggccgt accagcgggc gatcagttcc ttcggcagcc gcttcttcgc catgcccccg
    19561 agcgaggtct ccatgcgggc gaggaagggg aagcggaagg actgcaggag gaggaagagt
    19621 ccgccgggaa ccctggaggc cgcgtgcagc agccggccct ggacaccggg cggatagttc
    19681 tccagcgcct cgcaggaggt gaggacgagc cgtgcgacgc gctcgtcccg caccccgacc
    19741 aggagctggg ccgtacccgt gtcgttctgg acgagggtga cgtcgcgcag gtccaggcgc
    19801 tccatgaact ccgccagcag gcacgcgatc ccgtgcgcgg acaggtcggc gtcgggccgc
    19861 atcgggcgcc ggtggctgcc gatcggcagg acggggacca gtacccggaa gccgggccgc
    19921 atccgggcga cgacctcggc ccacaccgat ccgtcgaatc cgaggccgtg cgccaggacc
    19981 accacgggac cgtcgccccc ggtgtcgtcg tagtcgatgg ttcccgcgct cagttcgatc
    20041 tccggcatac cgtgcctccg cccggccgag tggccgcatc gtggtcgtgt ccgtggaacc
    20101 atctctagat agatcgttct agtgacagaa tagacaccga cccccgacgg cgacagcggc
    20161 ttcccggagg attcggaaga tgagcaaggg cagggccccc agcacccatg agacccggca
    20221 gcgcatcctg accgccggca cggagctgtt ccggcgcacg ggatacaccg gcaccggcat
    20281 gaaacagatc gccgcggccg ccggtgcccc cttcggctcg atctaccact tcttccccgg
    20341 cggcaaggcc cagctgggcg aggaggtggt ccgcacctcg ggcgccggct acctggagct
    20401 catcaccgcc ctgatgacgc cgtacgagga ccgggtcgcc gccaccgcgg acgccttcga
    20461 tgcggcggcc ggcaccctcg ccgaactgga cttcgccgac ccctgcccga tcgcgaccgt
    20521 cgcgatggag gtcgcgagca ccgacgagac gctacggcgc gccaccgccg aggtgttcga
    20581 cagctggacc ggccgcctcg ccgcctacta cgccgagggc ggcatcccgg aaccggccgc
    20641 ccgggagacg gccacgtcgg tcatcgccct gctggagggc gcgttcatgc tcggccgggc
    20701 cgcgcgcagc acggcaccgg tcctggcggc ggccagggcg gcggcggcga tcgtccgcgc
    20761 cgcgctggac gccggccgag ggtgacgacc ggcgtccagg gtgttggggg agacggccgg
    20821 tgaactcctg ccccgggtcc ggggcgagac tgtcgcggaa gcgcctcgga attgtccgtg
    20881 atccgtaaca gacggatccc gtgatcgcat ttcaccgtcc tgccaggtgc acggaatcca
    20941 tcggcatatc agggggcggg gcggacatgg cgcggcatgg cgggcgggga tggtacggcc
    21001 gagtggtcgc agcggcggtc ggggtcacgg cggtggccgc ggccacctcg gtgtggacgg
    21061 cgcaggccgg acagagcggc ggcgggtcag cggcaccgag cacctccgcc cggccggccg
    21121 cgcccgaggc ggcgcccgtg tccgagacca tcgcgcacgc ctccgccgcg ggcgcgcacg
    21181 cggtcaacat caccatcgac gacggcccgg acccggtctg gacgccgcag gtgctccaag
    21241 tgctgcgtga c
//
