LOCUS       NZ_JACHJK010000003     22166 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Streptomyces echinatus strain CECT 3313 Ga0436950_03, whole genome
            shotgun sequence.
ACCESSION   NZ_JACHJK010000003
VERSION     NZ_JACHJK010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces echinatus
  ORGANISM  Streptomyces echinatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 825906)
  AUTHORS   Whitman,W.
  TITLE     Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the
            genomes of soil and plant-associated and newly described type
            strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 825906)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 160.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014203595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 05:39:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,466
            CDSs (total)                      :: 8,381
            Genes (coding)                    :: 8,094
            CDSs (with protein)               :: 8,094
            Genes (RNA)                       :: 85
            rRNAs                             :: 7, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 5, 1 (5S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 287
            CDSs (without protein)            :: 287
            Pseudo Genes (ambiguous residues) :: 0 of 287
            Pseudo Genes (frameshifted)       :: 116 of 287
            Pseudo Genes (incomplete)         :: 236 of 287
            Pseudo Genes (internal stop)      :: 12 of 287
            Pseudo Genes (multiple problems)  :: 77 of 287
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 136824
            Orig. end                         :: 158990
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACHJK010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22166
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="2"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22166
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22166
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12166](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12166)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    480..495
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.45"
                     /tool="antismash"
     misc_feature    968..985
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            complement(1648..2310)
                     /locus_tag="FHS34_RS09195"
                     /old_locus_tag="FHS34_001865"
     CDS             complement(1648..2310)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018846478.1"
                     /locus_tag="FHS34_RS09195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001865"
                     /product="response regulator transcription factor"
                     /protein_id="WP_184963127.1"
                     /transl_table=11
                     /translation="MSIRVLVADDQTIIRTGLRIMLNAQPGIEVVGEAADGQEAVRLAR
                     ELRPDVCLFDIRMPVIDGLEATRLVAGPGVADPLAVVVITTFDLDEYVYGALRAGARGF
                     LLKDTGPDLLAQAVRSASGGEALIAPSVTVRLLQAFADLPAGRPVAQPVSAVTAREEQV
                     LLAVARGLTNTEIADALHISLSTVKTHLASLMAKLGARNRVEIAMWAYETRRILPGT"
     gene            complement(2285..3457)
                     /locus_tag="FHS34_RS09200"
                     /old_locus_tag="FHS34_001866"
     CDS             complement(2285..3457)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031367.1"
                     /locus_tag="FHS34_RS09200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001866"
                     /product="histidine kinase"
                     /protein_id="WP_184963130.1"
                     /transl_table=11
                     /translation="MLRDDLRTLWTEPRPPDAPARVWRDWALLAAGLVGVVLEATLREN
                     VVWRPVAVVFAVWLCVLPLWRRTRPLTTVVLAFGGMIVLQVVSLVATPRAPVGLYVGAV
                     VLLLVYALPRWGSGREIVLGGAVILAAGALCSVTDETPVVENVVGFVFLLLPGVVGAAV
                     RFRVTARERQLEQVRSREREQLARELHDTVAHHVSAMVIIAQAGRVLAGTDPSAAVEAL
                     EGVEEEGARTLEEMRAMVAALRDRGVGAQLAPPAGVADLERLVRTPGGRLRVDLGLHGE
                     LDTLPPAVDAAVYRIVQESVTNALRHAVDATELVVRVAAERHWVRVSVRDNGRRTGRGR
                     DGYGLTGLRERATLIGGTLRAGPGTDRGWHVEAELPRARSESGVHTRPRR"
     gene            3690..5903
                     /locus_tag="FHS34_RS09205"
                     /old_locus_tag="FHS34_001867"
     CDS             3690..5903
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018846480.1"
                     /locus_tag="FHS34_RS09205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001867"
                     /product="MMPL family transporter"
                     /protein_id="WP_225817306.1"
                     /transl_table=11
                     /translation="MIAAWLIAATLAVLAAIAIGGRTADSMTAPGLDSQRAAELIERAG
                     TGQEGMTAQVVVTPLDDGATFFDHGSARTALTRLQTEVKRLPHVLGTSDPAGALDAGGD
                     TTVRGGLVSADGRTAVVRVQYPDQSRLSAEDLDALVDLGDRLRAELPLRIEMGGNLFYV
                     FSDPDGGASELIGLLAAAAILFLAFGSLVAAALPIGMAVFGLTVGVATMTVLAGVTDVP
                     TFAPVLGSMVGLGVGIDYALFVLARHREYLARGLDPREAAGRAVATAGRPVVFAGGTVV
                     VSILGLAVANVPFMTVGGLAVSIVVLTMVVASVTLLPAFLGAAGPRLARADRIGRALQT
                     RKLGRLARRRNPAAGAAHAAGWRRWIGHVSRHPVPYVVGAAGLLLTATLPVLGLRVGLP
                     DDGSLPHSRTERRAYDLVAEGFGPGTNGPLVIAADPTGDPGVLDRLVGAVAADPGIASV
                     APTHIDRATGIATLVVFPTTSPQDKATADTIARLRTDVLPTAIGHGPARAHVGGAAASL
                     SDVGQRTSQRLPVLVAAVLAMSFLLLMLVFRSILVPLKAVLLNLLSIGAAYGIMVAVFQ
                     WGWGGALIGLEATVPIVSFIPMFLFAILFGLSMDYEVFLLSRVREEYLRTGDNGTAIVE
                     GVSRTARIITSAALIMVAVFLSFAVAEDPSTKMFGLGLATAIFIDATVVRMVLVPATMT
                     LLGRTNWWLPKWLDRMLPRGPVGTDDTDAESTGQARRPRLVDR"
     gene            6179..7393
                     /locus_tag="FHS34_RS09210"
                     /old_locus_tag="FHS34_001868"
     CDS             6179..7393
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557615.1"
                     /locus_tag="FHS34_RS09210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001868"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_225817307.1"
                     /transl_table=11
                     /translation="MDHSARITAFTGLVGPPPGPAPAVDWAAVEGWLGTPLPGDYKALV
                     SAYGAAEIGGPGAAIRLHPPCVSTDGRFEYAAWIVETHRHSAIRPGMFTARRRPFLPEE
                     GGLLAFATTRSGDHLFWNTGASDDPDEWPVTLMTTNVAVGVSEPWVDYEVPFLELLFTL
                     LRTGVPHPGEPGGLLGPLSSQIRVWPPLAGSAPWSPPPAGTAVDARQHAALTEGSGLDA
                     VMALVPPPLEPYLGEGTWEQVFERLGTRLPPDFVALAERYGAGNWSWWLDMSAPLSLDR
                     PREQGLAATVEGMLDGYRQLRAAHPQYYPMPAWPEPGGFLPFASTIDGDQIGWCADGPP
                     ETWRVAVNPRHCDQGPPLPGDFTATLLTWLRGGPAESGFPGLTGRDLHPLDVMFFEPFG
                     PGAPW"
     gene            complement(7484..7726)
                     /locus_tag="FHS34_RS43755"
                     /old_locus_tag="FHS34_001869"
     CDS             complement(7484..7726)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHS34_RS43755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHS34_001869"
                     /product="hypothetical protein"
                     /protein_id="WP_308288283.1"
                     /transl_table=11
                     /translation="MLPGGEGEEGHREAEDGSASDGPTLRTLTIVDPGIRARIALARRS
                     AGPASPAAKALLDSLRGRLRERLPAMAEVPETPAG"
     gene            complement(7642..7986)
                     /locus_tag="FHS34_RS09215"
     CDS             complement(7642..7986)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015431.5"
                     /locus_tag="FHS34_RS09215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_308288272.1"
                     /transl_table=11
                     /translation="MSFQTVIDVSLAVLAAAGDPLFERADATSVSLAELRDRALICLPR
                     GTGVRTALERACRRAGFPPRIAFEAAAPDVLVQLAARGWASRCCRAGRVRRGTGRPRTA
                     LLRTDPPCVP"
     misc_feature    8014..8027
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.43"
                     /tool="antismash"
     gene            complement(8437..8633)
                     /locus_tag="FHS34_RS09220"
                     /pseudo=""
     CDS             complement(8437..8633)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966491.1"
                     /locus_tag="FHS34_RS09220"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF3117 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSLNDGDFLQPRAKIRPRTGDGPLEVTEEGQGTCACRSKAAVGW"
     misc_feature    complement(9217..9231)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.13"
                     /tool="antismash"
     misc_feature    9253..9267
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.83"
                     /tool="antismash"
     misc_feature    complement(9278..9296)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.13"
                     /tool="antismash"
     misc_feature    complement(9295..9311)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 21.01"
                     /tool="antismash"
     gene            9383..9922
                     /locus_tag="FHS34_RS09225"
                     /old_locus_tag="FHS34_001872"
     CDS             9383..9922
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559519.1"
                     /locus_tag="FHS34_RS09225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001872"
                     /product="manganese efflux pump"
                     /protein_id="WP_184963136.1"
                     /transl_table=11
                     /translation="MIWEILILGFVLSLDNFRVSIALGTVPFGLKRAVQVSLTFGLWDA
                     IMPLVGLLVGHQIGESVGGVADVIGAAALGGYGLYLVISALRHPEPEELDHPWALFGIP
                     LTLSLDNLLAGASLGVLGLSPWFSAAVFGAMTAVLSLVGLQLGRAAARLIRIRSDLLSG
                     VVLIIAAAALPLWLGG"
     gene            complement(10001..11140)
                     /gene="pqqE"
                     /locus_tag="FHS34_RS09230"
                     /old_locus_tag="FHS34_001873"
     CDS             complement(10001..11140)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056910.1"
                     /locus_tag="FHS34_RS09230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001873"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_184963138.1"
                     /sec_met_domain="PF04055 (E-value: 1.4e-23, bitscore: 79.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.4e-09, bitscore: 32.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.9e-09, bitscore:
                     32.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSPFGLLAELTYRCPLACPYCSNPLNMAGYQDELATDEWRRVLV
                     EASDLGVLQCHLSGGEPLLRRDLVEIVADAHDLGLYTNLITSALGLSRPRAEQLRAAGL
                     DHVQISIQADEPTVSDRIAGIPSFQRKIEAMGVVKELGWPLTMNVVLHRHNIDRVADVL
                     ALAEEVGADRVELANTQYYGWAWRNRDALLPSRAQLEAAEVVVRAARERLRERMDVIYV
                     IPDYYSRYPKPCMGGWASRQLTVTPNGDVLPCPAAQPLPLPRASVREDPLERIWAEAPV
                     MTAFRGTDWMPEPCRSCYRRELDFGGCRCQAFLLTGDAARTDPVCCLSPDHDLVARAVE
                     AANSDSSEDLPLVPRPHRAGLPPVTRPRPGRPGRRSSPC"
     gene            complement(11133..11462)
                     /gene="pqqD"
                     /locus_tag="FHS34_RS09235"
                     /old_locus_tag="FHS34_001874"
     CDS             complement(11133..11462)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671045.1"
                     /locus_tag="FHS34_RS09235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001874"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_184963140.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.5e-21, bitscore:
                     70.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.4e-08,
                     bitscore: 28.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 8.3e-16, bitscore: 53.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 3.8e-07,
                     bitscore: 25.7, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPTHTAATRTATRTPPGAGVSGSDRPRLARHVRLTFCRTRQRKI
                     LLHPETVVVLNASGADILELCDGRHTVTEIVTELGARYQNVPEDEVRQFLTRLVARRWV
                     EVTDG"
     aSDomain        complement(11145..11360)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FHS34_RS09235_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.90E-09"
                     /identifier="RREFam002.1"
                     /label="FHS34_RS09235"
                     /locus_tag="FHS34_RS09235"
                     /protein_end="106"
                     /protein_start="34"
                     /score="28.4"
                     /tool="antismash"
                     /translation="LTFCRTRQRKILLHPETVVVLNASGADILELCDGRHTVTEIVTEL
                     GARYQNVPEDEVRQFLTRLVARRWVEV"
     aSDomain        complement(11148..11330)
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FHS34_RS09235_Pantocin_Microcin_RRE.1
                     "
                     /evalue="1.40E-08"
                     /identifier="RREFam017.1"
                     /label="FHS34_RS09235"
                     /locus_tag="FHS34_RS09235"
                     /protein_end="105"
                     /protein_start="44"
                     /score="25.7"
                     /tool="antismash"
                     /translation="ILLHPETVVVLNASGADILELCDGRHTVTEIVTELGARYQNVPED
                     EVRQFLTRLVARRWVE"
     aSDomain        complement(11148..11402)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FHS34_RS09235_PqqD_RRE.1"
                     /evalue="1.30E-22"
                     /identifier="RREFam006.1"
                     /label="FHS34_RS09235"
                     /locus_tag="FHS34_RS09235"
                     /protein_end="105"
                     /protein_start="20"
                     /score="70.4"
                     /tool="antismash"
                     /translation="VSGSDRPRLARHVRLTFCRTRQRKILLHPETVVVLNASGADILEL
                     CDGRHTVTEIVTELGARYQNVPEDEVRQFLTRLVARRWVE"
     gene            complement(11468..12166)
                     /gene="pqqC"
                     /locus_tag="FHS34_RS09240"
                     /old_locus_tag="FHS34_001875"
     CDS             complement(11468..12166)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671046.1"
                     /locus_tag="FHS34_RS09240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001875"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_184963142.1"
                     /sec_met_domain="TIGR02111 (E-value: 6e-97, bitscore:
                     319.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTIRTGADGFVETLRAQSRRYHDQHPFHVRMNAGRLSRRQIR
                     GWVANRFYYQENIPRKDAAILSNCPDLEVRRRWIRRILDHDGTATGEGGIEAWLRLGEA
                     AGLTREEIRDHRHLVPGVRFAVDSYVNFARTRPWVEAVASSLTELFAPDLMAARLAAFE
                     RWYPWIAPEALAYFRARLEQAPRDCEHALEVVTAHCLSAESQARAVDALSFKCDVLWGL
                     MDAIDQAYPE"
     gene            complement(12171..13058)
                     /gene="pqqB"
                     /locus_tag="FHS34_RS09245"
                     /old_locus_tag="FHS34_001876"
     CDS             complement(12171..13058)
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559515.1"
                     /locus_tag="FHS34_RS09245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001876"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_184963144.1"
                     /transl_table=11
                     /translation="MLLRVLGSAAGGGSPQWNCGCPVCAAVRSRAGLARTQSSVAISAD
                     SRRWFLINASPDLRTQIEAFPSLHPHDDRTTPLEAVLVTDAELDHTLGLLLLREARALR
                     LYATPTVRKTLSDGSGILRTLERYCPVEWRAVDPGADLALADGLSCRAFDVPTTKRDRF
                     GAGVDHGRVVGYRLTDERSKGTLVYLPGAQSLTPALRGEIEGCACLLIDGTCWRDDELI
                     RLGLAGKTSREMGHLPIDGPDGSLAQLPSMGVGRTIYVHMNNTNPILLEDAPERHTLEE
                     RGMEVAMDGLEIQV"
     gene            complement(13168..13263)
                     /gene="pqqA"
                     /locus_tag="FHS34_RS09250"
                     /old_locus_tag="FHS34_001877"
     CDS             complement(13168..13263)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: protein motif:HMM:NF019654.5"
                     /locus_tag="FHS34_RS09250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001877"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_184963147.1"
                     /transl_table=11
                     /translation="MESQPAEWETPEFEEITVAAEVTMYLDRLED"
     gene            complement(13312..15021)
                     /locus_tag="FHS34_RS09255"
                     /old_locus_tag="FHS34_001878"
     CDS             complement(13312..15021)
                     /EC_number="1.1.2.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671047.1"
                     /locus_tag="FHS34_RS09255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001878"
                     /product="PQQ-dependent dehydrogenase, methanol/ethanol
                     family"
                     /protein_id="WP_184963149.1"
                     /transl_table=11
                     /translation="MTVDYADYVDAGEAVDQGALSGKVAGGDVAPPVVAGVDYERLLNA
                     REEPQNWLTYYGAYNGQRYSPLDQINTDNVKRMVPAWVFQAGTTGLIAGASTYSFEAAP
                     IVVDGVMFLSGWDGWVWALDAKTGVEIWRYKHAVPFDVSLCCGNVNRGVAVAQGKVFFV
                     TANARVLALDATTGKRVWDKTYGDVRAGESATVAPLVVKNMVIVGSSGGEFGVRGHLDA
                     FDLETGEHQWRSYMVPKPGEPGSETWPADGEAWARGGANCWITGTFDPETNLLYVGTGN
                     PAPDFDGGVREGDNLFTDSIVAVDVDSGQIRWHYQCTPHDLWDYDSIGECILFEQDGRK
                     LLGHFDKNGYFFVLDRTNGARVSITPFVDRITWGAITRDGQVTAKVYPDKEGEPVHFYP
                     GPAGAKEWTHASYSPETGLFYVPVQDTGATATRRRREFKESIPYWGAGVQVDIEDMAGS
                     ISAFDAGGEEKWRWRNELPMCASTLVTGGDLVFAGEASGEFNALDARTGELLWQFQCGS
                     GHHSSPTTYMVDGRQYVAVPVGWGGWAEGFLPGMLGAGHGSALIVFALPEPS"
     gene            complement(15044..15505)
                     /locus_tag="FHS34_RS09260"
                     /old_locus_tag="FHS34_001879"
     CDS             complement(15044..15505)
                     /GO_process="GO:1901661 - quinone metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559512.1"
                     /locus_tag="FHS34_RS09260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001879"
                     /product="MSMEG_3727 family PQQ-associated protein"
                     /protein_id="WP_184963152.1"
                     /transl_table=11
                     /translation="MTTAQERADLLDQLGLAAQNKAALGQVLGTGSIGQATEESDGHMK
                     ATIRINPDELTWDPSILVMPHGGDIELELVNDDMNTHCALLPSNGDRKFIWLVNHSHGH
                     AHLNLDGPGYYWFGSPTGNDEGRGLTGSIVVLGDAPPEARLDRPEQPRP"
     gene            complement(15707..17995)
                     /gene="katG"
                     /locus_tag="FHS34_RS09265"
                     /old_locus_tag="FHS34_001880"
     CDS             complement(15707..17995)
                     /EC_number="1.11.1.21"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="katG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559511.1"
                     /locus_tag="FHS34_RS09265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001880"
                     /product="catalase/peroxidase HPI"
                     /protein_id="WP_184963154.1"
                     /transl_table=11
                     /translation="MSDSPDTVAGEKNAGGAGGLGLPGPAGHRGRATGGASNRDWWPDR
                     LDLAILRKHPAVADPMGEDFDYAAEFRTLDLGALARDVDEVLTTSQEWWPADFGHYGPL
                     MIRMVWHGAGTYRVADGRGGAGAGMQRFAPLNSWPDNRNLDKARRLLWPVKKKYGRKIS
                     WADLMVFAGNRALETMGLTTFGFAGGRADVWEPDEDVYWGPEHAWLGDERHGGVRELAN
                     PLAADQMGLIYVNPEGPNTVPDPLTAARDIRETFWRMGMNDEETVALIAGGHTFGKTHG
                     AADPVAHLGPDPEGAPLEEQGLGWKSSYGTGKGADAISSGLEGTWTPTPTRWDNSFFET
                     LFGYEWDLELSPAGLWQWIPRDGGGAGTVPDAHDPSTTHAPRILTTDLALRMDPVYEPI
                     SRRFLEHPDQLADAFARVWFKLTHLDMGPIQRYLGPLVPRETLRWQDPVPAVDHELVGA
                     ADISALKSRILASGLSVSQLVSTAWASASTFRVSDKRGGANGARIRLEPQRGWEVNEPD
                     TLAQVLRPLEGIQEAFNSSETGHKKISLADLIVLGGAAAVEQAARAAGHEVQVPFSPGR
                     TDATQEWTDVESFAPLEPAADGFRNYSGKGGRLPPEHALVDRANLLNLSAPEMTVLVGG
                     LRVLGANYQQSPLGVFTSAPGSLTNDFFVNLLDTGTEWKPTSETGETFEGRDRATGEVK
                     WTGSRVDLVFGSNSELRAIAEFYASDDAREKFVQDFVAAWAKVMNLDRYDLGAAPPGSS
                     QRRHIGYER"
     gene            complement(18036..19430)
                     /locus_tag="FHS34_RS09270"
                     /old_locus_tag="FHS34_001881"
     CDS             complement(18036..19430)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671050.1"
                     /locus_tag="FHS34_RS09270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_001881"
                     /product="DNA-binding protein"
                     /protein_id="WP_184963156.1"
                     /transl_table=11
                     /translation="MRHVRRLEPSSANLDSGTVLAAWERFVQGVDQVPDVRPLVAISWH
                     RCREQYRVDPHLTEAPVAVAELEHTPEHDVVFAELGFRAASVAHEVGSLGGVVTVTDAT
                     GRILAEWGDQATLARAGESNLAPWFCWSECAVGTNGMGTALEAHGPVRIRGAEHWCQAL
                     HDWVGAGIAVRDVVTREPIAVLGVCRWRSPLPAATESWLANAATMIQCPLKRHARDSGA
                     ELVAAYTQARAHSGAALAAVDTAGKVVIADDMASELLGVPACTPAVDPTLRWNPGLPEL
                     ITAARYAARQAAHNPDWIGSTQIFAHLADEPTSISIRPVFSFGRLIGNLVSFGASGGAQ
                     LPQAEGAAHLRAQPRRLVAMRDNRMVLLRLPEVSFAESQGNDVWLSTDQGRLRAASMSL
                     DKLEGELADVGFLRVHRRYVVNLSRIREIERGLKGELSLVMDDRAKEMVPVSRRHAAAV
                     RRALDI"
     misc_feature    20296..20311
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.2"
                     /tool="antismash"
     misc_feature    complement(20936..20951)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.41"
                     /tool="antismash"
     misc_feature    21753..21769
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.65"
                     /tool="antismash"
ORIGIN
        1 ccgccgcacg ctccgggtcg gagcccgtgc cgccgacgac gcgggtcagc agggccaccg
       61 cctcgtccat gtccagcggc gccagcgaga ccctgcggtc ggcatccagc ccggtcagcc
      121 gctgacgact ggtcaccagt acgaggctgc cgggaccggc gggcagcagg gggcgcacct
      181 gttgtgcagc gcacgcgtca tcgaccacca ggatcaaccg gaggacggcg gtcgccgctc
      241 tccacgacgc cgccaggccg tcaaggtcat gtgatgcgtc gtcgccttcg gtgatgtcgc
      301 cgactgcccg cagcaatcgg cgcagcacgc gctgcggggt cgctgcttcc cgcccctgcc
      361 ggtgaccatg aaggtccacg aacaggcagc catccggaaa acggtcttgc atggcacgcg
      421 cggcgcgtac gacgagcgcg gtcttgccga ccccggccat gccgtccacc gcacggaccg
      481 tcaccacctg gtcatcgtta ggcgcgagaa gcacctcaag ttcgtggttc cgcccggtga
      541 agccgttgac gccgaccggg agttcgttcc gcacacgtcg gagcgcgcga tcgactgcgg
      601 gccgctggtc cgtcgatcgg cgtgcccgtg gcgacgcgcc gacaaggaag gattcatcag
      661 cgcgcagcac cgcctcgtgc acccgccgca gttcaccgcc tggctccgct ccctgttcct
      721 gcaccagacg gcggcgcacc ttggcgaaga cagacagtgc gtccgcttgc cggttgccgg
      781 catagagggc acgcatcagc agagcggcca gggactcgtt gtgcggatgc gtttcggaca
      841 gagcgaacag ctctccgacg acctcggcgt gccgtcccag ctgcaactgg cactccacct
      901 tgtcccgcac cagcgcgagc ctgtgttccg acagccgtag acgctctgcc tcggcgaacg
      961 gcccagggat cccggagagg ggatctccgt ggaaaagctc cagagcggcc gaccacgcgc
     1021 tcaccgcggc ggccaggtca ccggaatccc gcccggcgtg cgcctcggtg acgatctccc
     1081 tcagccgggc tacgtccgtc cagacgtttc gtgggtctat gcggtagccg ccccgctcgg
     1141 tcacgatcag ggatccggag gcgcttcctc ggccaggatc cagacgtctg cgcagctggt
     1201 gcacatagac cggaatcacc ttggcaccgg tgcccggcgg ctccggcccc cacactccgt
     1261 cgagcaactg ctgccggctg acggtcgtgc ccggccgtaa cagcaacgcc gtcagcagag
     1321 cctgctgacg aaccgggccg aggtccagct gcacgtcgcc gcgccagacc cgcagcggac
     1381 cgagcacagc gaaccgcagt cggctgccac ccgtcggcgg ctcccccatc gatggcacgc
     1441 tggcgagtat aggcccgtcc cctcactctc ccggaagcac gggcttcacg cgggcagccg
     1501 ggcctgcgtc cgtccggcca ggcctggcgg gagccgatcc gaaggtcacg gccaagacgg
     1561 ggcgggtgac gcacgtggag ccgacgtgag ccgaccggtg cactgatgtc cgggcgggga
     1621 ctcaggggac atggcccggc acccaggtca ggttccgggg aggatacggc gggtttcgta
     1681 ggcccacatc gcgatctcga cccggttgcg ggcgccgagt ttggccatca ggctggccag
     1741 atgcgtcttc accgtgctga ggctgatgtg cagtgcatcg gcgatctcgg tgttggtcag
     1801 cccgcgagcg acggcgagga gcacctgctc ctcgcgggcg gtgacggcgg agaccggctg
     1861 ggccacgggt cggccggcgg gcaggtccgc gaatgcctgg agcagacgga cggtgacgct
     1921 gggcgcaatg agcgcctcac cgccggacgc cgaccgtacg gcctgcgcca gaaggtccgg
     1981 tccggtgtcc ttgaggagga atccgcgggc gccggcacgc agcgcgccgt agacgtactc
     2041 gtcgaggtcg aacgtggtga tgacgaccac ggccagcggg tcggcgacgc ccgggccggc
     2101 gaccagccgg gtggcctcga gcccgtcgat cacgggcatg cggatgtcga acaagcagac
     2161 gtcggggcgc agttcgcggg ccagacgtac cgcttcctgt ccgtcggcgg cctcgccgac
     2221 cacctcgatg ccgggctggg cgttcagcat gatccgcagc ccggtgcgga tgatcgtctg
     2281 gtcgtcagcg acgaggacgc gtatggacac cgctctcgct cctcgctctc ggcagctcgg
     2341 cttcgacatg ccagccccgg tcggtgcccg ggccggctcg tagtgtgccg ccgatcaggg
     2401 tcgcgcgctc gcgcagtccg gtaagtccgt atccgtcgcg accccggccg gtgcgccggc
     2461 cgttgtcgcg cacgctcacc cgtacccagt gccgttccgc ggcgacccga acgacgagct
     2521 cggtcgcgtc gaccgcgtgg cgcagcgcgt tggtcaccga ctcctgcacg atccggtaga
     2581 cggccgcgtc cacggccggg ggcagcgtgt ccagttcacc gtggagcccc aagtcgaccc
     2641 tgaggcgacc acccggggtg cgcaccaggc gctccagatc cgcgactccg gcagggggcg
     2701 ccagctgggc gccgactccg cggtcgcgca gcgcggcgac catggcgcgc atttcctcca
     2761 gcgtgcgcgc cccttcctcc tcgacccctt ccagcgcctc gacggcggcg gacgggtcgg
     2821 tgcccgcgag cacccggccc gcctgagcga tgatcaccat ggccgacacg tggtgggcca
     2881 ccgtgtcgtg cagttcccgg gcgagctgct cgcgctcgcg ggagcgcacc tgctccaact
     2941 gccgctcgcg agcggtcacc cggaaccgca cggcagcccc gaccacgccg ggcagcagca
     3001 ggaagacgaa gcccacgacg ttctcgacga ccggggtctc gtccgtgacg gaacacagcg
     3061 cgccggccgc gaggatcact gcgccgccca gcacgatctc gcgtcccgat ccccaccggg
     3121 gcagcgcgta caccagcagg aggacgaccg cgccgacgta cagaccgacc ggcgcccgag
     3181 gggtggccac cagcgagacc acctggagca cgatcatccc gccgaacgcg agcacgaccg
     3241 ttgtcagcgg gcgggtccgg cgccacaggg gcagcacgca cagccatacg gcgaacacca
     3301 ccgccaccgg ccgccacacg acgttctcgc gcagggtggc ctccagcacc acaccgacaa
     3361 ggcccgcggc gagcagcgcc cagtcccgcc acacccgggc gggcgcgtcg ggcggccggg
     3421 gttcggtcca cagggttcgc aggtcgtctc gcagcacggt tctcagccta ggggccgcgc
     3481 cgtgccgcgc atcggccgaa aggacgggtc gtcactccgc cccggggccg acggatccgc
     3541 ggcccgcgag ccgatgccgc agagcgccgt ggcgacgaac ctcggcatcg gcggccgtac
     3601 aaggacggcc gacgaggtgg ttggaggacc cgatgctctc gaaagccctg ttgcgcctgg
     3661 gcgcaagcgc cgcccgccat ccttggcggg tgatcgcggc atggctgatc gccgccacgc
     3721 tcgccgtcct cgccgcgatc gccatcggcg ggcggaccgc ggactcgatg accgctccgg
     3781 gactggactc ccaacgggcc gcggaactga tcgagcgggc aggcaccggc caggagggga
     3841 tgaccgccca agtggtcgtc acccccctcg acgacggtgc gacgttcttc gaccacggca
     3901 gcgcgcgcac cgctctcacg cggctgcaga ccgaggtgaa gcggctgccg cacgtgctcg
     3961 gcacgagcga cccggcgggg gcactcgacg caggcgggga caccaccgtg cgcggcggcc
     4021 ttgtctcggc cgacgggcgg accgcggtcg tccgggtgca gtaccccgac cagagccggc
     4081 tgtcggccga agacctcgac gccctcgtcg atctcggcga ccggctgcgc gccgagctgc
     4141 ccctgcgcat cgagatgggc gggaacctct tctacgtctt ctccgacccc gacggcggcg
     4201 caagcgagtt gatcggcctc ctcgccgccg ccgcgatcct gttcctggcg ttcggttcgc
     4261 tcgtcgccgc cgcgctgccg atcggcatgg cggtcttcgg gctgaccgta ggggtcgcca
     4321 cgatgacggt actggcgggg gtgacggacg tcccgacctt cgcccctgtc ctgggcagca
     4381 tggtcgggct cggagtgggc atcgactacg cgctgttcgt gctcgccagg caccgggagt
     4441 acctcgcgcg cgggctcgat ccccgcgagg cggcggggcg agcggtggcc acggcgggga
     4501 ggccggtggt cttcgccggc ggcaccgtcg tcgtatcgat cctcggcctg gcggtcgcga
     4561 acgtaccgtt catgacggtg ggcgggctcg ccgtctcgat cgtcgttctg accatggtgg
     4621 tcgcgtcggt gacgctgctg ccggccttcc tcggcgccgc cggcccacgc ctggcccggg
     4681 ccgaccggat cggccgggct ctgcagacca ggaagctggg ccgactcgca cggcggcgga
     4741 acccggcggc aggcgccgcc cacgccgccg ggtggcgtcg ctggatcggg cacgtcagcc
     4801 ggcacccggt gccgtacgtg gtcggcgcgg cggggctgct gctgaccgcg acgctgcccg
     4861 tgctcggcct gcgcgtcggc ctgcccgacg acggctcact gccccacagc cgtaccgagc
     4921 gccgggccta cgacctcgtc gccgaggggt tcggcccggg caccaacggt cccctcgtca
     4981 tcgccgcgga ccccaccggt gatccgggag tgctggaccg actcgtcggg gcggttgcgg
     5041 cggatccggg catcgcatcc gtcgcgccga cacacatcga tcgggccacc ggcatcgcga
     5101 ccctcgtggt gttcccgacc accagccctc aggacaaggc cacggccgac accatcgccc
     5161 ggctgcgcac cgacgtgctg cccacggcga tcgggcacgg cccggccagg gcccacgtcg
     5221 gcggcgccgc cgcgagcctg tccgatgtgg gccaacggac cagccaacgc ctgccggtgt
     5281 tggtcgccgc cgtcctggcg atgtcgttcc tgctgctgat gctggtcttc cgctcgatac
     5341 tcgtcccgct caaggcggtg ttgctgaatc tgctgagcat cggagcggcc tacggcatca
     5401 tggtcgcggt gttccagtgg ggctggggag gcgcactcat cgggctggaa gcgacggttc
     5461 cgatcgtgtc gttcatcccg atgttcctct tcgccatcct gttcggcctg tcgatggact
     5521 acgaggtgtt cctcctctcg cgcgtgcgcg aggagtacct gcgcaccggc gacaacggca
     5581 cggcgatcgt ggagggcgtc tcgcgcaccg ctcggatcat cacctcggcc gccctcatca
     5641 tggtggcggt cttcctgtcc ttcgccgtcg ccgaggaccc ctccaccaaa atgttcgggc
     5701 tcggcctggc caccgcgatc ttcatcgacg ccacggtcgt acgcatggtg ctggtaccgg
     5761 cgaccatgac actcctcggc cggaccaact ggtggctgcc gaagtggctg gaccggatgc
     5821 ttccccgcgg cccggtcggc accgacgaca ccgacgcgga atccacgggt caggcccggc
     5881 gtccacggct ggttgaccgt tgactcaact ctgcccgccc ttggcgtccg gcacctcagc
     5941 gcgtcaccta ggggcatatc aacaccgctg cgttaacgct gtgacctgca gggcaagggg
     6001 gttgggcgag gcaatgaggt catggtggcc cggccggtca cgcgcgctgt ggcaccgccc
     6061 gggagccgac ccgattcaac ccgaggacag ccgaagcgtc agtcagtggg cgggtcagac
     6121 gcccgagcgg tgccaggtcc cagtctcaat gtcggtgggg gatgtcatcc tcggctccat
     6181 ggatcactct gcgcggatca ccgcgttcac aggtctcgtc ggaccgccgc ccggcccggc
     6241 gcccgccgtc gactgggcgg cggtcgaggg ctggctcggc accccgctgc ccggtgacta
     6301 caaggcgctc gtgtcggcgt acggtgcggc cgagataggc ggcccgggtg cggcgatccg
     6361 gctgcacccc ccgtgcgtca gcaccgacgg ccgcttcgag tacgcagcat ggatcgtcga
     6421 gacgcaccgg cactcggcga tccggcccgg catgttcacc gcgcgtcggc gccccttcct
     6481 gcccgaggag ggcggcctgc tcgccttcgc cacgacgagg agcggcgacc acctcttctg
     6541 gaacacgggc gcgtcggacg accccgacga gtggccggtc acgctcatga ccacgaatgt
     6601 ggcagtcggg gtgagcgagc cctgggtgga ctacgaagtc ccgttcctgg agctgctgtt
     6661 cacgctgctg cgcaccggcg tgccgcaccc gggcgagccc ggcgggctgc tgggcccgct
     6721 ctcctcacag atacgggtct ggccgccgct ggccgggtcc gcaccctggt cgccaccgcc
     6781 tgcgggcacc gccgtggacg cgcggcagca cgcggcgctc accgagggct cgggcctcga
     6841 cgccgtcatg gcgctggttc caccgcccct ggagccgtac ctgggcgagg gcacatggga
     6901 gcaggtcttc gagcggctcg gcacccggct gccgccggac ttcgtggcgc tcgcggagcg
     6961 gtacggggcg ggcaactgga gctggtggct ggacatgagc gccccactgt ccctggaccg
     7021 gccacgggag caagggctcg cggccaccgt cgagggcatg cttgacggat accgccaact
     7081 gcgcgccgcc catccccagt actacccgat gcccgcgtgg cccgagcccg gcggcttcct
     7141 gccgttcgcg tcgacgatcg acggggacca gatcggctgg tgcgcggacg gcccgcccga
     7201 gacatggcgc gtagctgtca acccacgcca ctgcgaccaa ggaccgcccc tgccaggcga
     7261 cttcacggca accctgctca cgtggttgcg cggtggcccc gccgagtccg gcttccccgg
     7321 tctgaccggc cgggacctgc atccgctgga cgtcatgttc ttcgaaccgt tcgggccggg
     7381 cgcgccgtgg tgaaggcccc tcgtcaccac gggctgggac ctcagcaccg ttgcgttagg
     7441 gccatgagcg gctgttgagg ccgtgggcga tctgcgacac ccttcagccc gccggcgtct
     7501 cgggcacctc tgccatcgcc ggcaggcgct cgcgcagccg cccgcggagg ctgtccagca
     7561 gggccttcgc cgccgggctc gcggggccgg cggagcgccg ggcgagggca atgcgggcgc
     7621 ggatgccggg gtcgacgatg gtcagggtac gcagggtggg tccgtccgaa gcagagccgt
     7681 cctcggcctc ccggtgcccc tcctcaccct ccccgcccgg cagcaccgcg acgcccagcc
     7741 ccgggccgcc agctgcacca acacatctgg cgccgccgcc tcgaaggcga ttcgaggcgg
     7801 aaatcccgcc cgtcggcagg cccgttccag cgccgtccgc accccggtcc cccgcggcag
     7861 gcagatcagg gcccggtcgc gcagctcggc cagggacacg ctcgtggcgt cggcccgttc
     7921 gaagagcggg tccccggccg ccgccaggac cgccagcgag acgtcgatca ccgtctggaa
     7981 ggacatcaac ctatccggga ggactgacag ttgagaacaa tcgatcttcg cggggttcct
     8041 cacaccgtcc tggggtggac gccgtttcgc cctgacggcg aaacggctac ctctgccctg
     8101 ctccgcagga gtccgattcc tccccgcccc aaaggacggg ccatcctcgg aggaacccgg
     8161 tgaacaagcg ccgtgccgct ggccgccggt gcggcgcgga tcgctgacga gccgaatcac
     8221 acgatgagac agccgagtcg ggctccgcgg acaacggcac gcaagactgc ggcccagggc
     8281 ccccgaggct tcatggatgc gacacccccc tagctgttcg cgaggccctg cccttatgcc
     8341 ccaccgaccg gaagaccacc cgaccgaagc cacgtcccac cgtcaggcga cctctgcggt
     8401 acgccaacta ctttccagtc ccgctgacca acggcatcag ccgacgacgt tcctgagtcc
     8461 gtcggcgagg gcgccggcct cgtccggggt cagatcgact accagccgac cgccgccttc
     8521 gagcggcacg cgcatgtgcc ctgcccctcc tcggtcactt cgagcggacc gtcgcctgtc
     8581 cgtggcctga tcttggcgcg cggctgaagg aaatcaccgt cgttgaggga cagcgcccgc
     8641 gttccgttgc cctcgatctt gactgtgcac tcccccagag cgggggtcgc ggtggcggca
     8701 ggcgtcagga cgaccgtgac ccctggaacg aacgatgagg cgacgagcga gatgacggcg
     8761 ttgcatcgga tgcgccgggc catgatgggt gtgctccctc gcgatgagtg gagggcgccg
     8821 cggaaacacg ggggcaagtc gccgcgccag cgctccggga gtggcccctc caaccacagc
     8881 gcgacaacgg atgtacggct gtggcaccgc tgcgacgcca gactgatcgg aaggcgccgc
     8941 tccatccatc ctggttgttg ttcaccggcc caaggttcgc cagcgtggga aagcgcacgc
     9001 tcctcctacc cggtgggcga tcccctgctg ttctggacgc tggacctgct ggccccctac
     9061 gtggccttcg gcaaccccgg tccgggagtc tgggacaggg tcgtcgacgt actgagccgg
     9121 gtcgcgcggg ggcgacgacg gccagtcagt caccggcgcg ggccgcaacg gcccacagaa
     9181 acagcgaggc ctgccggttc aatcaacgag ctcttctgga agtgatagcc accgtcgggc
     9241 gagcagcgtc gaaatattat ggaaatcacc ttacaggttt atattgtgaa ccatctgaga
     9301 tattatgacg aattatggcg gatactaacc gagtcagagt cgtttccgcc ggcgtcggtc
     9361 gtcgttgggc agctacctcg ccatgatctg ggaaatattg atcctgggtt ttgtactcag
     9421 cctcgacaat ttccgggtat ccatcgcgct cggcacggtc ccattcggtt tgaagcgcgc
     9481 ggtgcaggtc tcgctcacct tcgggctgtg ggacgcgatc atgcccctcg tcggactgtt
     9541 ggtcggtcat cagatcgggg agtccgtcgg aggagtggcc gatgtgatcg gcgcggccgc
     9601 gctcggcgga tacggcctct acctcgtcat ctcggccctt cgtcaccccg agccggaaga
     9661 gttggaccac ccgtgggcct tgttcggcat cccgctgaca ctgagcctgg acaacttgct
     9721 cgccggagcg agcctggggg tccttgggct ctcgccttgg ttttcggccg ccgtcttcgg
     9781 cgccatgacg gcggtgttgt cactggtcgg gctgcaactc ggacgggccg cggcacgcct
     9841 catccggatc cgctcggacc tgctgagcgg ggtcgtcttg atcatcgccg ctgcggcgct
     9901 gccgttgtgg ttgggcggct gacccgctcc accgggaggc aggcgggcct gcaggcagga
     9961 gatcagcggc agatcgccga tccgcgcgtc agcacgccac tcagcatggg ctgcttcgac
    10021 ggcccgggcg accaggtcgc ggccgggtga caggtggcag accggctcgg tgcgggcggg
    10081 ggaccagcgg aagatcctct gacgagtcgg agttggcggc ctccaccgcc cgggcgacca
    10141 ggtcgtggtc gggtgacagg cagcagaccg ggtcggtgcg ggcggcgtcg ccggtgagca
    10201 ggaatgcctg gcagcggcac ccaccgaagt ccagctcccg ccggtagcag ctccgacagg
    10261 gctccggcat ccagtcggtc ccccgaaacg cggtcatcac cggggcctcg gcccagatcc
    10321 gctccagcgg gtcctcacgc acgctggccc gcggcaacgg caggggctgg gcagccgggc
    10381 agggcagaac gtcgccgttc ggtgtcacgg tcagctgccg ggaggcccaa ccgcccatgc
    10441 agggcttcgg gtagcggctg tagtagtcgg ggatgacata gatgacgtcc atgcgttccc
    10501 gcagccgctc gcgggcggcc cgcaccacga cctcggccgc ctcgagctgg gcccggctcg
    10561 gcagcagcgc gtcacggttt cgccaggccc agccgtagta ctgggtgttg gccagctcca
    10621 cccggtcggc gcccacctcc tcggccaggg cgagcacgtc ggcgacgcgg tcgatgttgt
    10681 gccggtgcag caccacgttc atggtgagcg gccagcccag ttccttgacc acgcccatcg
    10741 cctcgatctt gcgttggaag gacgggatcc cggcaatccg gtcggacacg gtcggttcgt
    10801 cggcctggat gctgatctgc acatggtcca gaccggcggc ccgcagctgc tcggccctcg
    10861 gacgcgagag cccgagcgcg ctggttatga gattggtgta gaggcccagg tcgtgggcgt
    10921 ccgccacgat ctccaccagg tcgcgccgca gcaacggttc cccgccggac aggtggcact
    10981 gcagaacccc caggtcactg gcctcgacca gcacccgccg ccactcgtcg gtggccagct
    11041 cgtcctggta gccggccatg ttgagcgggt tggagcagta cgggcaggcc aaagggcagc
    11101 ggtaggtgag ctcggcgagc aacccgaacg ggctatccat cggtgacctc cacccagcgc
    11161 cgggcgacga gccgggtcag gaactgccgc acctcgtcct cgggaacgtt ctggtaacgg
    11221 gcgcccagct cggtcacgat ctcggtcacg gtgtgccgcc cgtcgcacag ctcgaggatg
    11281 tccgcgccgc tggcgttcag aaccaccacc gtctcggggt gcagcaggat cttgcgctgc
    11341 ctggtccggc agaaggtcag ccggacatgg cgcgccaacc ggggccggtc cgagccggac
    11401 acccctgcgc cgggcggggt cctggttgcg gtgcgggtcg ctgcggtatg tgtcgggtcc
    11461 atggtggtca ctccgggtag gcctggtcga tggcgtccat caggccccac aggacgtcgc
    11521 acttgaacga cagcgcgtcg acggcgcgtg cctgggactc ggcggagagg cagtgggcgg
    11581 tgaccacctc gagggcgtgt tcgcagtcgc ggggtgcctg ttccaggcgg gcgcggaaat
    11641 aggcaagggc ctcgggggcg atccacgggt accaccgctc gaacgcggcc agccgcgccg
    11701 ccatcaggtc gggcgcgaac agctcggtga gggaggacgc caccgcctcc acccacggcc
    11761 gggtccgggc gaagttcacg taggagtcga cggcgaaccg cacgccgggt accaggtgcc
    11821 ggtggtcccg gatctcctca cgggtcagcc cggcggcctc gccgaggcgc agccacgcct
    11881 cgatgccgcc ctcgccggtt gcggtgccgt cgtggtcgag gatccgtcgg atccagcggc
    11941 ggcggacctc gaggtcaggg cagttggaca ggatcgcggc gtccttgcgg gggatgttct
    12001 cctggtagta gaagcggttg gccacccagc cccggatctg gcggcggctc agccggccgg
    12061 cgttcatccg cacgtggaac gggtgctggt cgtggtatcg ccgcgactgg gcccgcaacg
    12121 tctcgacgaa gccgtcggcg ccggttctga tggtggttgt cgtcacggct ctacacctgg
    12181 atttcaaggc cgtccatggc cacttccata ccgcgctcct ccaaggtatg ccgctcgggc
    12241 gcgtcctcca ggaggatcgg gttggtgttg ttcatgtgca cgtagatcgt ccgccccacg
    12301 cccatcgacg ggagctgcgc gagactgccg tccgggccgt cgatgggcag gtgccccatc
    12361 tcccgggacg tcttgccggc caggccgagc cgtatgagct cgtcgtcgcg ccagcaggtc
    12421 ccgtcgatca gcaggcatgc gcagccctcg atctccccgc gcagtgccgg tgtcagcgat
    12481 tgcgctcctg gcaggtacac gagcgttccc ttgctgcgct cgtcggtcag ccggtagccc
    12541 acgacgcggc cgtggtccac cccggctccg aaccgatcgc gcttggtggt gggcacgtcg
    12601 aacgcccggc aggacagccc gtccgccagg gcgaggtcgg cgcctggatc cactgcccgc
    12661 cactcgaccg ggcagtaacg ttcgagcgtg cgcagaatcc ccgagccgtc agacagggtc
    12721 ttgcgcaccg tcggcgtggc gtagagccgc agggcgcggg cctcgcgcag caggagcagg
    12781 cccagcgtgt ggtccagctc ggcgtcggtg acgagcaccg cctccagcgg cgtcgtccgg
    12841 tcgtcgtgcg ggtgcagact ggggaaggcc tcgatctggg tgcggagatc gggcgaggcg
    12901 ttgatgagga accaccggcg gctgtcggcg ctgatggcga ccgacgactg ggtgcgcgcg
    12961 aggccggcgc gggagcggac cgcggcgcac accgggcagc cgcagttcca ctgcggggag
    13021 ccgccccccg cagcggagcc cagcactcgc agcaacacgc cggcactccg ttcatcgaag
    13081 atccgggtcc gtcaccggcc cggccgtccg tggccatcgc gagccgccgg agggcgccgg
    13141 acaaggtccg acgccgcccc acgtccgcta gtcctccagc cgatcgaggt acatggtcac
    13201 ctcggccgcg actgtgatct cctcaaactc gggcgtctcc cattcagcgg gctgagactc
    13261 catggattca cctcctttct gaccgaattc cggcaggctc cgagtcccgt gctacgacgg
    13321 ttccgggagg gcgaagacga tcagggcgct tccgtgcccc gcgccgagca tgccggggag
    13381 gaatccctcg gcccatccgc cccagccgac cggcacggcc acgtactgcc tgccgtcgac
    13441 catgtaggtg gtcgggctgc tgtggtggcc gctaccgcac tggaactgcc acagcagctc
    13501 cccggtgcgg gcgtcgagcg cgttgaactc gccggaggcc tcgcccgcga acaccaggtc
    13561 accgccggtg accagcgtcg aggcgcacat cgggagttcg ttgcgccagc gccacttctc
    13621 ctcgccgcca gcgtcgaacg cgctgatgga ccccgccatg tcctcgatgt cgacctgaac
    13681 gcccgcgccc cagtagggaa tgctctcctt gaactcccgg cgccgccggg tggcggtggc
    13741 accggtgtcc tggaccggga cgtagaagag cccggtctcg gggctgtagg acgcatgggt
    13801 ccattccttg gcgccggccg gacccgggta gaagtggacc ggttctccct ccttgtccgg
    13861 gtacaccttg gccgtcacct ggccgtccct cgtgatcgcc ccccatgtga tgcggtcgac
    13921 gaagggagtg atcgagaccc tcgcgccgtt cgtgcggtcg aggacgaaga agtagccgtt
    13981 cttgtcgaag tgcccgagca gtttgcgccc gtcctgctcg aacaggatgc actcgccgat
    14041 gctgtcgtaa tcccacaggt cgtgtggcgt gcactggtag tgccagcgga tctgaccgct
    14101 gtccacgtcc acggcgacga tgctgtcggt gaagaggttg tcgccctcgc ggacccctcc
    14161 gtcgaagtcg ggcgccgggt tgccggtgcc cacgtacagc aggttcgtct ccgggtcgaa
    14221 ggtaccggtg atccagcagt tcgccccgcc ccgtgcccag gcctcgccgt cggcgggcca
    14281 ggtctccgag ccgggctccc cgggcttggg caccatgtag ctgcgccact ggtgctcgcc
    14341 ggtctcgaga tcgaatgcgt cgaggtggcc gcgtacgccg aactcgccgc cggaacttcc
    14401 gacgatgacc atgttcttca cgaccagcgg ggcgactgtg gcgctctccc cggcccggac
    14461 gtctccgtag gtcttgtccc agacccgctt gccggtggtg gcgtcgagcg cgagcacacg
    14521 ggcgttcgcc gtgacgaaga agaccttccc ctgagccacg gcgaccccgc ggttcacgtt
    14581 cccgcagcac aaggacacgt cgaaggggac ggcgtgcttg taccgccaga tctccacgcc
    14641 cgtcttcgcg tcgagggccc agacccagcc gtcccagccg gagaggaaca tgaccccgtc
    14701 gacgacgatc ggggcggcct cgaacgagta ggtcgacgcg cccgcgatca ggccggtcgt
    14761 gccggcctgg aagacccaag cggggaccat gcgtttgacg ttgtccgtgt tgatctggtc
    14821 cagcgggctg taccgctgcc cgttgtaggc gccgtagtag gtgagccagt tctggggttc
    14881 ctcgcgagcg ttcaacaggc gctcgtagtc gacgccggct actaccggcg gcgcgacgtc
    14941 cccgcccgcg accttgccgc tcagggctcc ctgatcgacg gcctcacccg cgtcgacgta
    15001 gtcggcgtag tcgacggtca ttccctccac ctcctacttc ttcctacggc cgcggctgtt
    15061 cgggacggtc gaggcgagcc tccggagggg cgtctcccag gaccacgatg gacccggtca
    15121 gcccccggcc ctcgtcattg cctgtgggcg agccgaacca gtagtagccc gggccgtcga
    15181 gattgaggtg cgcatgcccg tgcgaatggt tcaccaacca gatgaacttc ctgtcgccgt
    15241 tgctcggcag aagtgcgcag tgcgtgttca tgtcgtcatt gacgagctcg agctcgatat
    15301 cgcctccatg gggcatgacc agaatagagg gatcccaggt cagctcatcc gggttgatgc
    15361 gtattgtggc cttcatgtgg ccgtccgatt cctcggtggc ctgcccgata cttccggttc
    15421 ccagcacttg ccccagcgct gctttgttct gtgcggccaa cccgagctgg tccagcaggt
    15481 cggcccgctc ctgcgcggtc gtcataggag gttccactcc tcgaaatctc tatttctgca
    15541 ccaccgatgc ccggctgcaa tcggtcgtca aggagcgcac tgcgccggat aaatcgcacc
    15601 cgatatggtg ctgaattcgc agttgccaaa aacgctacgc cgggtggatc acgccgacaa
    15661 ggtgcgccca ggtgcgggcc gtttcatgcc gttcgtccgc gacgggctac cgttcatacc
    15721 cgatgtgccg ccgttgggag gagccgggcg gcgccgcacc gaggtcgtac cggtcgaggt
    15781 tcatgacctt ggcccatgcg gcgacgaagt cctggacgaa cttctcccgt gcgtcgtcgc
    15841 tcgcgtagaa ctccgcgatg gcacgcagct cggagttcga gccgaagacg aggtcgacgc
    15901 ggctaccggt ccacttgacc tcgccggtgg cgcgatcgcg cccctcgaag gtttccccgg
    15961 tctcggaggt gggcttccat tccgtgcccg tgtcgagcag attcacgaag aagtcgttgg
    16021 tcagcgaccc gggcgccgag gtgaagacgc ccagcggcga ctgctggtag ttggcgccca
    16081 gcacccgcag gccacccacg aggacggtca tctcgggcgc gctcaggttc agcaggttcg
    16141 cgcggtcgac cagcgcgtgc tcgggcggca gccggccgcc cttgccgctg tagttgcgga
    16201 acccgtccgc ggccggctcg agcggggcga aggactccac atctgtccac tcctgtgtgg
    16261 cgtccgtgcg tcccgggctg aaggggacct ggacttcgtg gccggcggcc ctggcggcct
    16321 gctcgacggc ggcggctccg ccgagcacga tgaggtcggc cagtgagatc ttcttgtgcc
    16381 cggtctcgga gctgttgaag gcctcctgga tcccctccag ggggcgcagc acctgtgcca
    16441 gggtgtcggg ctcgttgacc tcccagcccc gctgcggctc gaggcggatg cgcgcgccgt
    16501 tcgccccgcc gcgcttgtca ctgacgcgga acgtcgaggc cgacgcccag gcggtcgaga
    16561 cgagctggga gacggacagc ccggaggcga ggatccggct cttgagcgcg gagatgtccg
    16621 ccgccccgac gagctcgtgg tccacagcgg ggaccgggtc ctgccagcgc agcgtctccc
    16681 ggggaaccag gggtccgagg tagcgctgga tcgggcccat gtcgaggtgc gtcagcttga
    16741 accagacgcg ggcgaacgca tccgcgagct ggtccgggtg ctccaggaag cgtcgcgaga
    16801 tcggctcgta gaccgggtcc atccgcaagg cgaggtccgt cgtcaggatc ctcggggcgt
    16861 gtgtcgtcga tgggtcgtgg gcgtccggca cggtaccggc cccgccgccg tctctcggga
    16921 tccactgcca cagacccgcg gggctcagct ccaggtccca ctcgtagccg aacagggtct
    16981 cgaagaagct gttgtcccat ctcgtcgggg tgggtgtcca ggtgccctcc aacccgctgg
    17041 agatggcgtc cgcgcccttt ccggtgccgt agctgctctt ccagcccaag ccttgctcct
    17101 cgaggggggc gccctcgggg tcggggccga ggtgggcgac cgggtcggcc gcgccgtggg
    17161 tcttgccgaa ggtgtggccg cccgcgatca gcgcgacggt ctcctcgtcg ttcatcccca
    17221 tgcgccagaa cgtctcgcgg atgtctcggg ccgcggtgag tgggtcgggg acggtgttcg
    17281 gtccctccgg gttgacgtag atgaggccca tctggtcggc ggccagaggg ttcgccagct
    17341 cccggacgcc gccgtgccgt tcatcgccca gccaggcgtg ctcgggaccc cagtagacgt
    17401 cctcgtcggg ctcccagacg tccgcccggc cgccggcgaa gccgaaggtc gtgaggccca
    17461 tcgtctccag ggcacggttg cccgcgaaga ccatcaggtc ggcccaggag atcttgcggc
    17521 cgtacttctt cttcaccggc cagagcagcc ggcgcgcctt gtcgaggttg cggttgtccg
    17581 gccagctgtt cagcggtgcg aaacgctgca tgccggcgcc cgcgcccccg cggccgtcgg
    17641 cgacgcggta cgtacccgcc ccgtgccaca ccatccggat catgagcggc ccgtagtgac
    17701 cgaagtcggc cggccaccac tcctgcgacg tcgtgagcac ctcgtcgacg tcccgtgcca
    17761 gggcgccgag gtcgagcgtc cggaactccg cggcgtaatc gaagtcctcg cccatgggat
    17821 cggccacggc ggggtgtttc cggagaatcg ccaggtcgag ccggtccggc caccagtcgc
    17881 ggttgctcgc gccccccgtc gcgcgaccgc ggtgcccggc cgggccggga aggccgaggc
    17941 cacccgcgcc cccggcgttc ttctcgccgg cgacagtgtc aggactgtcg gacacgggac
    18001 tcctccttcc gggagcaggg gtcgtgccgg gccgctcaga tgtccagcgc gcgacgcacg
    18061 gccgccgcgt gccgccggga aaccggcacc atctccttcg cccggtcgtc catgaccaga
    18121 gaaagctcgc ccttgaggcc gcgctctatc tccctgatgc ggctgaggtt gaccacatac
    18181 cggcggtgca cccgcaggaa gccgacatcc gccagctcac cttcgagttt gtccagactc
    18241 atggaggcgg cccgcagtcg cccctgatcg gtggagagcc atacgtcgtt tccctgcgat
    18301 tcggcgaagg agacttctgg cagccgcagc agcaccatcc ggttgtcccg catcgcgacc
    18361 agtcggcgcg gctgcgcccg aaggtgcgcg gccccctccg cctggggcag ctgcgccccg
    18421 ccggaggcac cgaacgagac caggttcccg atcaggcgtc cgaaggagaa gacgggtcgg
    18481 atgctgatcg aggtcggttc gtcggcgagg tgggcgaaga tctgcgtcga gccgatccag
    18541 tcgggattgt gggccgcctg cctggcggca taccgggcgg cagtgatcag ttcgggcagc
    18601 ccggggttcc accgcagtgt ggggtcgacc gccggggtgc atgccgggac gcccaggagc
    18661 tcgcttgcca tgtcgtcggc gatcaccacc ttgcctgcgg tgtccaccgc ggcgagtgcc
    18721 gcaccggagt gcgccctggc ctgggtgtag gccgcgacca actcggcacc gctgtcccgg
    18781 gcgtgcctct tcagcgggca ctggatcatg gtggccgcgt tcgccagcca gctttccgtg
    18841 gccgcaggaa gcgggctgcg ccagcggcag acaccgagga ccgcgatcgg ttccctggtc
    18901 accacgtcgc gcaccgcgat gcccgcgccg acccagtcgt ggagcgcctg gcaccagtgt
    18961 tccgcgcccc tgatccgcac cgggccgtgc gcctccagcg ccgtgcccat gccgttcgtg
    19021 ccgaccgcgc actcggacca gcagaaccag ggcgccagat tggactcacc ggctctggcg
    19081 agcgtggcct ggtcacccca ctcggccagg atgcggccgg tggcatcggt gacagtgacg
    19141 acgcccccga ggctgcccac ctcatgtgcc acggaggcgg cacgaaaacc cagctcagcg
    19201 aatacgacat cgtgctcggg cgtgtgctcg agctccgcga cggccaccgg agcctccgtg
    19261 aggtgaggat cgacccggta ctgctctcgg cagcgatgcc aggagatcgc caccaggggc
    19321 cggacatccg ggacctggtc cacgccctgc acgaaccgtt cccatgccgc gagcacggtg
    19381 ccgctgtcca ggttcgccga gctgggttca agccgacgta catgcctcat ggttcagaac
    19441 cgtccttggt ccatccccga cgcccgacgg tgtgagcgcc gtccgcgccg gtcgccgctc
    19501 ctcgcggccg ggccggcagc ggactggggc ccgcgtcgcg cgtcctcctg cttcgtcact
    19561 cgttccaggc tgtgtcacag gcctgcactc cccaccctag gtaccgttgt ccaccggcgc
    19621 acgtgcctct ccaggccacc cggacgaact tggagcaggc cgggagcacg cctgaccgct
    19681 cccggatccg tgactcggcc gacaggaggc cgaccctgcg gagcgatgcg gatcgcttgc
    19741 cggcctcgac gcccgagcca tagtcctgac ctgcgggttc gtccaagtat tcgatcttgg
    19801 acttgatgat gtaccggcgg cccggtgcag accccaggca ccggccaggc ggttccggcc
    19861 gtagccgtac ttctcggcga tctccggtgg cgtgatctcg tagccgtccc tgcggcgcag
    19921 ggcgacggtc gcaggcgcag gaccctcagg ttggggttgt tcgcatcatc gacagtctca
    19981 ttgaacgcgg gcagccgaag atcgtggcaa cgcccggagt tcgtgacggg gcttcaccct
    20041 catcatgatc caccgcgatg gtctacgaac gccccatacg ggaccgcctc aggcgatcgc
    20101 gccggccggg atggcctgct ccgtccagat gatcttgccg gtcgtggtgt aacgggtgcc
    20161 ccacctgtgg gcgagctggg cgacgatcaa caggccccgt cctccctcgt cagtggtccg
    20221 cgcatggcgg agacgtggag aagtactgct ggcgtcggag acctcgcaaa tcaggccgcg
    20281 atcccggatc agacgcagac cgactggtcc ggccgcatgc cgaatggcat tggtgaccag
    20341 ttcgctgacg atgagttccg tggtgaacgt cagatcgggg atcccccact cggacacctg
    20401 ctggatggcg agggtacggg cgtgcgcgac ggcagccgga tcgctgggca ggtcccagaa
    20461 ggccacctgg tccggggcca ggacgcgggt ccgagcgagg agcagggccg cgtcgtcggg
    20521 cggtgggccg gccaggagag tctcgatcac tcgttggccg gtctccgtca gggaaggcag
    20581 gggcgccgcg agggcattgc ccagccggga aagcccgatg tcgatgtccc ggtcgaccga
    20641 ttcgatgagg ccgtcggtgt agagggcgat caggctgcct tcggccagct ctgtctcgat
    20701 ggactggaag gggaggtagc cgaggccgag tggtggtccg gcgggcaggt ccaggatgtc
    20761 ggcggcgccg tcggggccga cgatcatcgg ggggaggtgg ccggcccggg ccatgctgca
    20821 ccgcccgctg accgggtcgt agacggcgta caggcaggtg gcgcccagga acgcggtgcc
    20881 cgtcgcctcg ccctccgccg ccgtgggagc atcggcgtgc gctcccatga gaccgatgac
    20941 caggtcgtcc agatgagcca gtagctcgtc cggggagagg tcgaggttgg cgagcgtgcg
    21001 cacggcggtc cgcaggcgcc ccatggtcgc tgccgcattg atgccgtgcc cggccacgtc
    21061 tcccacgacc agtgctacgc gtgcgccgga gagcggaatc acgtcgaacc agtcgccgcc
    21121 cacaccactg gggacatccg cggggaggta ccaggaggcc atctccagag cggatcctcc
    21181 ggtcaggtcc tgcggcagca ggtagcgctg catggaccgg gccgcggtgc gttcgcgggt
    21241 gaaacggcgt gcgttgtcga tgcacaccgc cgcgcgggag acgagttcct cggcgagacg
    21301 tgcgtcgtcg tcctcgaagg ggcccagtcg ccgggagcga gcgaacgtcg ccacgcccag
    21361 ggtgacgccg cgtgcccgca ccggaatcac catcaccgag cggaggtcgt ggtcgaggag
    21421 cgaggcaccc agcgtctcgt ccatggtcaa ccaccgactg ctggcgccgt ccaagatctt
    21481 ctcgaccagg gttctactct ccatcaagca gcgggtcacc ggcgacgaag gggctcgccg
    21541 gactgtctcc cccacggcca gggaggcctc gggacaacct tcgcgtaccg actgctgcgc
    21601 cgcgcgtcgg atgacgggcg ccatgccgac cggccccggt gccggttcct cgcccctcat
    21661 gacgccgtcc agcaggtcga cggcgacgaa gtccgccacg gccggcaccg cgtcgtcggc
    21721 cagttcctgc gcggtccgcg tcacgtccag ggtgctgccg atgcgggcag cggcctcgtt
    21781 gagcagggcc agtcgttcct gagcccgcca ccgctcggtg atgtcgatga tcatgtacca
    21841 cacgcctacg ttccggtcgt ggcggtcctt catcgcgaag aaggaggcgg agatcgcccg
    21901 ggttcggtcg ggctccgaaa ggttcgcccc ccggtattcg aagtccatga ccggggaccc
    21961 ggtctccagg acgagccgca tgcgctcctc gaaggcctcg gcctcggcct tcggcagtac
    22021 gtccgccatc cgccgcccca gcctccgttt caaggggatc tgctggtcga gtggctcgtt
    22081 cacccagacg taccgaaggt ccgtgtcgag gacggcgatg ccgaccggtg cgtgacggag
    22141 gaagggggtg agcatcagct gactga
//
