LOCUS       NZ_JACHJK010000001     10474 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Streptomyces echinatus strain CECT 3313 Ga0436950_01, whole genome
            shotgun sequence.
ACCESSION   NZ_JACHJK010000001
VERSION     NZ_JACHJK010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces echinatus
  ORGANISM  Streptomyces echinatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1030765)
  AUTHORS   Whitman,W.
  TITLE     Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the
            genomes of soil and plant-associated and newly described type
            strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1030765)
  AUTHORS   Whitman,W., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 160.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014203595.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 05:39:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,466
            CDSs (total)                      :: 8,381
            Genes (coding)                    :: 8,094
            CDSs (with protein)               :: 8,094
            Genes (RNA)                       :: 85
            rRNAs                             :: 7, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 5, 1 (5S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 287
            CDSs (without protein)            :: 287
            Pseudo Genes (ambiguous residues) :: 0 of 287
            Pseudo Genes (frameshifted)       :: 116 of 287
            Pseudo Genes (incomplete)         :: 236 of 287
            Pseudo Genes (internal stop)      :: 12 of 287
            Pseudo Genes (multiple problems)  :: 77 of 287
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:56:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 371339
            Orig. end                         :: 381813
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACHJK010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10474
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="2"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10474
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10474
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5474](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5474
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(159..174)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.27"
                     /tool="antismash"
     misc_feature    complement(862..877)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            1012..1251
                     /locus_tag="FHS34_RS01600"
                     /old_locus_tag="FHS34_000313"
     CDS             1012..1251
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056482.1"
                     /locus_tag="FHS34_RS01600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000313"
                     /product="chaplin"
                     /protein_id="WP_184959163.1"
                     /transl_table=11
                     /translation="MSRIAKGLVLTYAAVAAVAAGAGVAAADAGATGFAANSPGVLSGN
                     AVEVPIHLPINVCGNTVDVIGALNPAFGNACVSD"
     gene            1424..2359
                     /locus_tag="FHS34_RS41860"
                     /old_locus_tag="FHS34_000314"
     CDS             1424..2359
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHS34_RS41860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHS34_000314"
                     /product="hypothetical protein"
                     /protein_id="WP_221508405.1"
                     /transl_table=11
                     /translation="MRDLPARRLASTVLCAAVLVGITGPAVAAADTARHQGRVPAPVPA
                     AAKEKLLAQARALGDTNPVLSPVVELLDQSLQKGKLPADRARQLGEAAKEAVARAAADP
                     KPATPTATAAPTATAKPATPTATAAPTTTAKPATPTATAAPTTTAEPAKPTATAKPAAE
                     VSPTAPVTAKPAAPTGTAAPTATAKPATPTASAAPAAPTASGVPASPAAPASSAAPAAL
                     TAPVAARHANVGVPSSRDLLGDALSAVQTAIDNLVKAVTDGLDQLLSSADDVVSGLVDL
                     LTSVLGGGLPTNTLAELPSPAALPSLPTTG"
     gene            2492..2884
                     /locus_tag="FHS34_RS43690"
                     /old_locus_tag="FHS34_000315"
     CDS             2492..2884
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358350.1"
                     /locus_tag="FHS34_RS43690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000315"
                     /product="hypothetical protein"
                     /protein_id="WP_308288328.1"
                     /transl_table=11
                     /translation="MKSLKAAAVVAGTVALAGITAPAFADDTSDWTPTSLNGAVNKLTE
                     EPITLKDAMPIRHQPDVVDTKSTGSLRHEGKGKGKGKGKGKGKGKGKGTGKGKSTGKGT
                     GKSTGKAVGTTSNQHKPLLGGLPLHG"
     gene            3085..3576
                     /locus_tag="FHS34_RS01615"
                     /old_locus_tag="FHS34_000316"
     CDS             3085..3576
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065676.1"
                     /locus_tag="FHS34_RS01615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000316"
                     /product="DUF5949 family protein"
                     /protein_id="WP_184959165.1"
                     /transl_table=11
                     /translation="MTTTPLENRPAGLGTLVVLAWSGEAPDGSDMPYLLAYSLGDAAGG
                     PEATAAAVERLLVSNGLPVGGELIDGTGRPGLPVSLLVAAGQAVVRMPQMVAQADAPPE
                     WLAAVRERGYAYLVFTTRAWPEGAPGQVVEPAALAAFAGAEETLQAAAHVVLPVTSLRG
                     "
     gene            3573..4160
                     /locus_tag="FHS34_RS01620"
                     /old_locus_tag="FHS34_000317"
     CDS             3573..4160
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019359676.1"
                     /locus_tag="FHS34_RS01620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000317"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_184959167.1"
                     /transl_table=11
                     /translation="MTSRAPAGDRGFGLLLVITGAAGLLASWVITLDEFKLLENPAFVP
                     GCSLNPVVSCGSVMKSDQASVFGFPNPMLGLVAYAVVICVGMSLLAGARFPGWYWLLFE
                     AGCLFGIGFVSWLQFESLYRIDALCLWCCLAWIATILIFWYATALIVRAGFLPAPGRLK
                     RFFGEFGWVLPQLHLGVIGMLVLTRWWDFWTS"
     gene            4291..4809
                     /locus_tag="FHS34_RS01625"
                     /old_locus_tag="FHS34_000318"
     CDS             4291..4809
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976098.1"
                     /locus_tag="FHS34_RS01625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000318"
                     /product="hypothetical protein"
                     /protein_id="WP_184959169.1"
                     /transl_table=11
                     /translation="MKPTTRATLAAVITGVTAAVGAAATPAVAATGTIPVPVPLDGVSR
                     SLGVEMPQAVLDVPLLTPGVPEGPRFVTGRLMPERTVPQVPIRGALPGVNLRTPVPHLI
                     GGGADHIGVGTPASALRTLTPGLALDAPLTPPNPGRADLPDLKMPQAAVIGPVLQTVAG
                     ADLSTGPGR"
     gene            complement(4940..5029)
                     /locus_tag="FHS34_RS43985"
     CDS             complement(4940..5029)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01409.1"
                     /locus_tag="FHS34_RS43985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_372478611.1"
                     /transl_table=11
                     /translation="MACCSAPTATPPTPTAMLAPRPGSDVRTG"
     gene            5001..5474
                     /locus_tag="FHS34_RS01630"
                     /old_locus_tag="FHS34_000319"
     CDS             5001..5474
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007499741.1"
                     /locus_tag="FHS34_RS01630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000319"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_225817721.1"
                     /sec_met_domain="melC (E-value: 4.5e-45, bitscore: 149.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVGAEQQATAEPVRRSRREVARGLLGSAAVLAMAPVVAASRPLP
                     TAGPADAGAFDETYRGRRIQGVQVSDTGRTLVDGVWQITVDGRPLHLMRRADGTWLSII
                     DHYTSYRTPLEATRAAVDELGPHRKLRDLAPGRFGGEHSGVHTGEGGQHGVRA"
     gene            5458..6324
                     /locus_tag="FHS34_RS01635"
                     /old_locus_tag="FHS34_000320"
     CDS             5458..6324
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116480.1"
                     /locus_tag="FHS34_RS01635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000320"
                     /product="tyrosinase family protein"
                     /protein_id="WP_184959173.1"
                     /transl_table=11
                     /translation="MVYVRKDVSTLTAGERRRFVNALLELKRRGEYDEFVRLHIDVYTA
                     DGENGLRSAHMAPSFLPWHRRFVLELERALRRVDSSVTVPYWDWTRNRKATSVPWTKDL
                     LGGNGRRSDRQVTTGPFAYAAGHWTIKEGVTDGRFLTRDLGRAAAPIQLPTKSELQWAL
                     ADPVYDVRPWNSTVRKGFRNKLEGWGSGSGSASWLNHNRVHRWVGGAMLGGASVNDPVF
                     WMHHAFLDLQWTRWQRAHRSHRYLPAEPPGAGDAQHGRVVARHEKLPPWDETPDQLEDL
                     SRIYRYG"
     gene            complement(6397..6684)
                     /locus_tag="FHS34_RS01640"
                     /old_locus_tag="FHS34_000321"
     CDS             complement(6397..6684)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672799.1"
                     /locus_tag="FHS34_RS01640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000321"
                     /product="chaplin"
                     /protein_id="WP_184959175.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVALGTGAVVVSGSGLALADSGALGAATGSPGVVSGN
                     VVQVPLHVPVNVCGNTVDVIALLNPAFGNACANIDDHDTPGTPGGNGYGN"
     gene            6983..7597
                     /locus_tag="FHS34_RS01645"
                     /old_locus_tag="FHS34_000322"
     CDS             6983..7597
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016326259.1"
                     /locus_tag="FHS34_RS01645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000322"
                     /product="DUF2087 domain-containing protein"
                     /protein_id="WP_184959177.1"
                     /transl_table=11
                     /translation="MDTDNVPDTRERSRQLIGLLADESRLRAFAAIALGARSAGQVAET
                     AGLPPRETALALLRLREQGAVTGRGREAAGGRSGRSENGGALPGGAEEGLAVSYDLLRE
                     LARPERPARPAGGGTLETFVRDGRLVRLPARWTRKQQVLRHIAEQTFEPGVAYPERVVN
                     ERLRAWCQESDEIDHVTLRRYLVDLGELRRSEGVYERVAAA"
     gene            complement(7608..8567)
                     /locus_tag="FHS34_RS01650"
                     /old_locus_tag="FHS34_000323"
     CDS             complement(7608..8567)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672797.1"
                     /locus_tag="FHS34_RS01650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000323"
                     /product="D-2-hydroxyacid dehydrogenase family protein"
                     /protein_id="WP_184959178.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 4.8e-53, bitscore:
                     174.9, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRCAVLDDFQGVAAESADWSVIEDQVDVVPLREHLDGEDALAA
                     ALADYDIVVTLRERVPFPGSLIARLPRLKLLVASGMRNSVIDYAAAEAHGVTVCGTASS
                     STPPVELTWALLLGLARGIVQESNALRGDGPWQSTVGADLHGRRLGLLGLGKIGGRVAQ
                     VGLAFGMRVSAWSQNLTKERAGEAGVELAASKEELLGDSDFVSIHLALGDRTRGLVGAA
                     ELALMKPTAYLVNTSRAAIVDQDALLAALREGRIAGAGVDVFDVEPLPAGHPMRSAPRL
                     LATPHLGYVSRANYATYYGQAVEDIQAYLAGSPLRRLP"
     gene            8734..9129
                     /locus_tag="FHS34_RS01655"
                     /old_locus_tag="FHS34_000324"
     CDS             8734..9129
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985123.1"
                     /locus_tag="FHS34_RS01655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHS34_000324"
                     /product="hypothetical protein"
                     /protein_id="WP_184959180.1"
                     /transl_table=11
                     /translation="MLLEPENTLFVRGATPVLLLAGAPVHDALPQLSAPDGAIPLCEGW
                     SIVPRLTLCVVDGPGDHGIVVPALAAPVVGEADGGTAPGDMADWCADAEQAGGAVVLSL
                     DRLPETLDWSALLSSGTTRGGFLPALA"
     gene            9274..9468
                     /locus_tag="FHS34_RS01660"
                     /old_locus_tag="FHS34_000325"
     CDS             9274..9468
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHS34_RS01660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHS34_000325"
                     /product="hypothetical protein"
                     /protein_id="WP_184961362.1"
                     /transl_table=11
                     /translation="MSHGLRRITGLTIMIAGIALGAWVAFGSPQHWHGAQALGRMALGL
                     GSLGMISASPRLIFPDASD"
     misc_feature    9286..9288
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9303..9318
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
     gene            9694..10020
                     /locus_tag="FHS34_RS01665"
                     /old_locus_tag="FHS34_000326"
     CDS             9694..10020
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FHS34_RS01665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FHS34_000326"
                     /product="hypothetical protein"
                     /protein_id="WP_184959182.1"
                     /transl_table=11
                     /translation="MVKAINTANGSPGADTLRLARKCTYKLTSPNATDPANGLPTVTSE
                     ITIEGNGATITRAKSASDFRILLVGASGTLMLNRTTISGGRATDCRSSPEARSAGAAST
                     TREP"
ORIGIN
        1 gctcccagcg cagcgcgagt gccgcggtga gtccgccgac cgcctcgaag gaccaggcgt
       61 gcggctggaa cacggtcggg gtccgcccgc ggaccgcgag ccgcgcggcc agaccggcct
      121 tcgcgctgtg cgcgtgcacc agttcgggcc ggacctcgtc gatcagccgt acgagccgtc
      181 gcacctcacc cggcaggccg ggtcccgggg acctgcccgc ccgccagtcg cggacgtcgg
      241 cgcccagcgc ccgcaggtcc gtggcgagcg caccgtcggg gcaggcgatc gtgacccgct
      301 ggcccgccgc gagctgagct ctcgtcaggt cggtcacgac gcgggccaca ccgccgtcga
      361 cgggttgcgc gaggtgcagg acccggggcc gcagggcggg tgctgactgg tgcattcgcg
      421 ggatacctcg ctcacgggac gctcgggact gcgggcgtga acgcgtcttc ggttccgggc
      481 gtccacgagg cggagggcgc gccggcccac gccacgtccg cgtgggaaac gagccggaag
      541 cccggctggt caccaccgtg cctcagagcc ggtccgagac cgtgcacgtc gtggtcgtag
      601 acgaccgtgt cggcgcaggc aggcacccgc ccggccggta cggcaccccg gttcgccggc
      661 cgtggatccg ctacgtcgtt cgcggggcca cacggagccg cgcggtgcga ccggcgtacg
      721 ccggaggccg gtggcgaggg tgagcggaag cccggtcccg gcagcctcgt acgccctgcc
      781 gccgaccctt cctcggtgga gggcgggccg cacgacgggg gagtgcggtc acgtaatgcc
      841 atcggccatt cgcatctatc ggtctaaaag gtgcgaagtg tttttaaagg tgtgatcatg
      901 tctcttccgt acatcacccc attggcggca caacccgcgc gagggccgcg cgttgacaca
      961 gcgccgggtg tccgcccgga cgtttgtgtc gaccccaagg agcacttctc catgtcgcgt
     1021 atcgcgaagg gcctggtcct gacctacgcc gccgtcgcgg ccgtcgccgc tggtgccggc
     1081 gtggccgccg ccgacgccgg cgccaccggt ttcgccgcca actcgccggg tgtcctgtcg
     1141 ggtaacgccg tcgaggtccc gatccacctg ccgatcaacg tctgcggcaa caccgtcgac
     1201 gtcatcggtg cgctgaaccc ggcgttcggc aacgcctgcg tcagcgactg acgtcggaac
     1261 gcagatcttc cggccggccg cccaccccgc gcatgcgctg cgaggcggac ggccggtttc
     1321 gcgctccctc ggacggatca cagcgggtgt gtgagcggtt gcgccgcgcg atgggcgaac
     1381 agacggtggg cacaggtccc actgttcgcc gaaaggaaag tccatgcgtg atctgcccgc
     1441 ccggcgtctc gcgtccaccg tcctctgtgc ggccgtcctg gtcggcatca ccggcccggc
     1501 cgtcgccgcc gccgacacgg cccggcatca ggggcgtgtc cccgcccctg tcccggccgc
     1561 ggcgaaggag aagctgctcg cccaggccag agccctgggt gatacgaacc ccgtgctctc
     1621 tccggtcgtc gaactgctcg accagtcgct gcagaagggc aagctccccg ccgaccgggc
     1681 ccgacagctg ggcgaggcgg cgaaggaggc tgtggccagg gccgccgccg acccgaagcc
     1741 cgcgacgccg acggccactg ccgctccgac ggcgaccgcg aagcccgcga cgccgacggc
     1801 cactgccgcg cccacgacaa ccgccaagcc cgcgacgccg acggccactg ccgcgcccac
     1861 gacaaccgcc gagcccgcga agccgactgc gaccgcgaag cctgcggccg aggtgtcgcc
     1921 cacggcgccg gtgaccgcga agcccgcggc cccgacgggc accgccgcgc ccacggcgac
     1981 cgccaagccc gccaccccca ccgcgtccgc ggcgccggcc gcgcccacgg cctccggcgt
     2041 ccccgcgtcc cctgccgctc ccgcgagttc cgccgccccc gcggccctca cagcccctgt
     2101 ggccgcacgg cacgcgaacg tcggcgtgcc ctcctcccgc gacctcctcg gtgacgcgct
     2161 cagcgcagtg cagaccgcga tcgacaacct ggtgaaggcg gtcaccgacg gcctcgacca
     2221 gctcctgtcg tccgccgacg acgtggtgtc cggcctggta gacctgctga cgtccgtcct
     2281 cggtggcggc ctgcccacga acactctggc cgaacttccc tcgccggccg cgctgccgag
     2341 cctgcccacg accggctgag ccggggttcc gccggcccgg tcggggattt catatgtctt
     2401 ctgcgcgtgg ggtttccggc tcgtccggaa ctcgttgggc acggtgtcag aattccctgc
     2461 ggcgacttgc gttgccgatg aaaggaacac gatgaagtcc ctgaaggctg ccgccgtcgt
     2521 cgccggaacc gtggctctcg cgggcatcac cgcgcccgcg ttcgccgacg acacctccga
     2581 ctggacgccc accagcctca acggtgccgt caacaagctc accgaggagc ccatcaccct
     2641 caaggacgcg atgccgatca ggcaccagcc ggacgtggtc gacaccaaga gcacgggctc
     2701 gctgcgccac gagggcaagg gcaagggcaa gggcaagggc aagggcaagg gcaagggcaa
     2761 gggcaagggc acgggcaagg gcaagagcac gggcaagggc acgggcaaga gcacgggcaa
     2821 ggccgtcggc accacgtcga accagcacaa gccactcctc ggtgggctgc ccctccacgg
     2881 ctgacacccc gtccccgcac ccggaacact caggaggcga gaggccggac acgtaggagg
     2941 cgaggggccg gtaccgcacc cgcggcaccg gcccccggcc tgttcgaggc caattccctc
     3001 gttcgtgtgg agcgctcccg ggcgctggtc cggaagggtg agaagtcgtc cggcggtgcc
     3061 agggggcgcc ggtacggtcg cgcggtgacc acaacccccc tcgagaaccg tcccgccggg
     3121 ctcggcacgc tcgtcgtcct ggcctggagc ggcgaggccc ccgacggctc cgacatgccc
     3181 tacctgctgg cctactccct cggtgacgcc gcgggcggcc cggaggcgac cgccgccgcg
     3241 gtcgagcggc tgctggtgag caacgggctg ccggtcggcg gcgagctgat cgacggcacc
     3301 ggccggcccg gcctcccggt cagtctgctg gtggcggccg gccaggccgt cgtccgaatg
     3361 ccgcagatgg tcgcccaggc cgacgcgccg ccggagtggc tcgccgcggt cagggaacgt
     3421 ggttacgcct atctcgtctt caccacccgc gcctggcccg agggcgcgcc cggccaggtc
     3481 gtcgagccgg cggcgctggc cgcgttcgcc ggtgccgagg agacgctgca ggccgcggcg
     3541 cacgtcgtcc tgccggtcac cagcctgcgc ggatgacgtc cagggccccc gccggtgaca
     3601 gggggttcgg tctactcctg gtgatcaccg gcgcggccgg actgctcgcc tcctgggtca
     3661 tcaccctgga cgagttcaag ctgctcgaga accccgcgtt cgtgcccggg tgcagtctga
     3721 acccggtggt gtcctgcggg agcgtgatga agagcgacca ggcctcggtc ttcgggttcc
     3781 ccaatccgat gctggggctg gtggcctacg ccgtggtgat ctgcgtcggc atgagcctgc
     3841 tggccggcgc ccgcttcccc ggctggtact ggctgctgtt cgaggccggt tgcctgttcg
     3901 gcatcgggtt cgtctcgtgg ctccagttcg agtcgctgta ccggatcgac gcgctctgcc
     3961 tgtggtgctg tctggcctgg atcgccacca ttctcatctt ctggtacgcc accgcactca
     4021 tcgttcgagc cgggttcctg cccgcccccg gccggctgaa gcgcttcttc ggtgaattcg
     4081 gctgggtgct gccccagctc catctcggag tgatcggaat gctcgtactc acccgctggt
     4141 gggacttctg gacgagctga ccatcgcccg gacggctgtg accagctgac aaatacggca
     4201 atcgggcgaa aagtgaactg gtggcgaatt ccggctcgtt acccggtacg gacgtcgatt
     4261 ccccgcatcc tgaaagggac cgtacctgac atgaagccga ccacccgagc aacgctcgcc
     4321 gccgtcatca cgggcgtcac ggccgccgtg ggggccgcgg ccacccccgc cgtcgccgcg
     4381 accggcacga tcccggtccc cgtgccgctg gacggcgtct ccaggtccct gggtgtggag
     4441 atgccccagg ccgtcctgga cgtgccgttg ctgacgccgg gggtgcccga ggggccgcgc
     4501 ttcgtcaccg ggcggctgat gccggaacgc accgttcccc aggtgccgat caggggtgcc
     4561 ctgcccggcg tgaacctccg gacgcccgtg ccgcacctca tcggcggcgg ggccgaccac
     4621 atcggtgtcg gcacccccgc ctccgccctg cgcaccctca cccccggcct ggccctggac
     4681 gccccgctga ccccgccgaa cccgggccgt gccgacctcc cggacctgaa gatgccgcag
     4741 gccgccgtca tcggcccggt cctgcagacc gtggccggcg cggacctcag cacgggcccg
     4801 ggacggtagc cgcgcacggc cggaccgccg tccggccgca cggccgtacc cgccgtacgt
     4861 acggccacac ggccgcacgg ccgcacggcc gtacccgccg tatggctcta cggcggtgac
     4921 cccgcgcccc ctcggccggt tagccggtac ggacatctga acccggacga ggagcgagca
     4981 tggctgtggg tgtgggcgga gtggcggtcg gcgcggagca acaggccaca gcggaacccg
     5041 tcagaaggtc acggcgggag gtggcgcggg ggctgctggg ctccgccgcc gtgctggcga
     5101 tggccccggt cgtcgccgct tcccggcccc tgcccaccgc cgggccggca gacgccggag
     5161 ccttcgacga gacgtaccgg ggccgccgta tccagggagt gcaggtttcc gacacgggcc
     5221 gcacgctggt ggacggcgtt tggcagatca ccgtcgacgg ccgtccgctg cacctgatgc
     5281 gccgggccga cggcacctgg ctgagcatca tcgaccacta cacgtcgtat cgcacgccgc
     5341 tggaggcgac acgggcggca gtggacgagc tggggcccca ccggaagttg cgcgacctgg
     5401 cgccgggccg gttcggcggc gagcactccg gtgtgcacac gggggagggc ggacagcatg
     5461 gtgtacgtgc gtaaggacgt cagcacgctc accgccgggg agcgcagaag gttcgtgaac
     5521 gcgctgctgg aactcaagcg gcgtggtgag tacgacgaat tcgtccgcct gcacatcgac
     5581 gtctacaccg ccgacggcga gaacggactg cgcagcgccc acatggcgcc ctccttcctg
     5641 ccctggcacc gcaggttcgt gctggagctg gagcgggcgc tgcgtcgcgt cgactcctcg
     5701 gtgacggtcc cgtactggga ctggacccgg aaccgcaagg cgacgtccgt gccatggacg
     5761 aaggatctgc tcggcgggaa cggcaggcgc tccgaccggc aggtgacgac cggcccgttc
     5821 gcctacgcgg cgggccactg gaccatcaag gagggggtca ccgacggcag gttcctcacc
     5881 cgggacctgg gccgcgccgc cgcccccatc cagctgccca cgaagagcga gctgcaatgg
     5941 gcactcgccg atcccgtcta cgacgtgcgg ccctggaact ccaccgtccg caaggggttc
     6001 cgcaacaagc tggagggctg ggggagcggc agcggcagcg cctcctggct caaccacaat
     6061 cgagtgcacc ggtgggtcgg cggcgcgatg ctcggcggcg cgtccgtcaa cgacccggtg
     6121 ttctggatgc atcacgcctt cctcgacctg cagtggacgc gctggcagcg ggcccaccgc
     6181 agccaccgct atctgccggc cgagccgccc ggggccggtg acgctcagca cgggcgggtc
     6241 gtcgctcggc acgagaagct cccgccgtgg gacgagacgc cggaccagct ggaggatctg
     6301 agcaggatct atcgctacgg ctgagcacct ggtcgtggac gtgggggagc cccggcgctc
     6361 ggagtgccgg ggctcccgtc cgctgtgccg gtccgctcag ttgccgtacc cgttgccgcc
     6421 gggcgtaccg ggcgtgtcgt ggtcgtcgat gttggcgcag gcgttgccga aggccgggtt
     6481 cagcagggcg atcacgtcga cggtgttccc gcacacgttg accgggacgt ggagcggaac
     6541 ctggaccacg ttgccggaca ccacgccggg cgatccggtg gccgcgccga gggcgcccga
     6601 gtcggcgagg gccagcccgg acccactgac caccacggca ccggtgccga gagcgacagc
     6661 ggctgccttc gcgatgcgag acatcacgtt ctccttttgt agctcggtaa gcgcggcggc
     6721 cagaccagcc gccgcactcc ccgttcaacg gcggggcgcg gggtgggtca cgcagatcag
     6781 ccggggatca cccgttcaac ggccggtctg tccgggaggg agtcccgggt gaggtggcgg
     6841 ggtgtgtccg gcggggtgtc cagggtgagg tggcggggtg tggccggcgg ggtgcccggg
     6901 gggaagcggc ggggctgccg cggcgcggaa ccgcggggaa attcacgggc gcgcggcggg
     6961 gccggtctcc taccctccgg ccatggacac cgacaacgtt cccgatacgc gcgagcggtc
     7021 ccggcaactg atcggtctgc tggccgacga gagccggctg cgggccttcg ccgcgatcgc
     7081 actgggcgcg cggagcgccg gccaggtcgc cgagacggcc ggcctcccgc cgagggaaac
     7141 ggccctcgcg ctgctcagac tgcgcgagca gggtgccgtg accggccggg gccgggaggc
     7201 cgccgggggt cggagcggcc ggagtgagaa cggcggggcg ctgcccggcg gggcggagga
     7261 agggctcgcg gtctcctacg acctgctgcg cgagctggcc cggccggaaa ggcccgcgcg
     7321 gccggccggc ggcggcacac tggagacttt cgtacgggac ggccggctgg tgcggctgcc
     7381 cgccaggtgg acccgtaagc agcaagtgct gcggcacatc gcggagcaga ccttcgagcc
     7441 gggcgtcgcc tatccggagc gggtcgtgaa cgagcgcctg cgcgcctggt gccaggaatc
     7501 cgacgagatc gaccatgtga cgctccggcg ctatctcgtg gacctgggcg agctgcgccg
     7561 gagcgagggc gtctacgaac gtgtggcggc cgcctgaccg gacggcctca gggcagccgc
     7621 cgcagcgggg agcccgccag ataggcctgg atgtcctcca cggcctggcc gtagtacgtc
     7681 gcgtagttgg cgcgcgagac gtagccgagg tggggcgtgg cgaggagccg gggcgcgctg
     7741 cgcatcggat ggccggcggg cagcggctcg acgtcgaaga catcgacgcc ggcgccggcg
     7801 atccggccct cgcgcagcgc ggccagcagc gcgtcctggt cgacgatggc cgcgcgggag
     7861 gtgttgacca ggtaggcggt cggcttcatc agggcgagtt cggcggcgcc gacgagaccg
     7921 cgggtgcggt cgccgagggc cagatggatg gagacgaagt cgctgtcgcc cagcaactcc
     7981 tccttggagg cggccagttc cacaccggcc tccccggcgc gctccttggt gaggttctgg
     8041 ctccaggcgc tcacccgcat gccgaaggcg agcccgacct gggcgacccg gccgccgatc
     8101 ttgcccagcc cgagcagccc cagccggcgg ccgtgcagat cggcgccgac ggtcgactgc
     8161 caggggccgt cgccgcgcag ggcgttgctc tcctggacga tcccgcgggc gagcccgagc
     8221 agcagtgccc aggtcagctc gaccggcggg gtgctcgaac tcgccgtacc gcacacggtg
     8281 acgccgtgcg cctcggcggc ggcgtagtcg atgacgctgt tgcgcatccc ggaggcgacg
     8341 agcagcttga gccggggcag gcgggcgatc agggagcccg ggaaggggac gcgttcgcgc
     8401 agggtgacga cgatgtcgta gtcggcgagg gccgcggcga gggcgtcctc accgtcgagg
     8461 tgctcgcgca gcgggacgac gtccacctga tcctcgatca ccgaccagtc ggccgattcg
     8521 gcggccaccc cctggaagtc gtccagcacc gcacaccgaa gccgcatgtc gtctcccttc
     8581 cccgggcgac tgtaccgatc ggccccggaa cgcgaccgac agggtcaccc cgcccttcgc
     8641 cccgcgactc ccgggccccc cgtccccggt caactcctac cggccaactc cccctggccc
     8701 gctcctctcc ccccagcctg gaagagtggc cccatgctgc tcgaacccga gaacacgctg
     8761 ttcgtccgtg gtgccacgcc cgtgctcctg ctggcggggg cgcccgtcca cgacgccctg
     8821 ccgcaactga gcgcgcccga cggggcgata cccctgtgcg agggctggag catcgtgccc
     8881 cggctcaccc tgtgcgtggt ggacggcccg ggcgaccacg gaatcgtggt gcccgccctc
     8941 gccgcgccgg tggtcggcga ggccgacggc ggtacggcgc cgggcgacat ggccgactgg
     9001 tgcgcggacg ccgagcaggc cggcggcgcg gtcgtcctgt cgctggaccg gctgcccgag
     9061 acgctcgact ggtccgcgct cctgtcctcg ggcaccacgc gcggaggctt cctgcccgcc
     9121 ctggcctgac accacgtgac accggcttgg cagaccgaca gcacacccgc cggccggcct
     9181 gccgaacccg gccccgccga acctttcgcg ccgagcgact cggagcggga tttttctgtt
     9241 gagcaccgat gggtgatcgg caaccatggg cccatgagtc acggcttacg tcgcatcacc
     9301 ggactgacga tcatgatcgc gggcatcgcg ttgggtgcct gggtggcctt cgggtcccca
     9361 cagcactggc acggcgccca agccctgggg cgcatggcgc tgggcctggg atccctgggg
     9421 atgatcagcg cctcaccccg cctgatcttc cccgacgcct cggattgatc accgaagacg
     9481 cggcggtgcc cggcgacacg gccccccgcc ggcagaagcg accggccgcc ccagcagaac
     9541 ccgaaccaga gaccaagcac cgagaagacg ctcggcacga cgcgggtcac ccccgctgac
     9601 ctgctcctcc cgccctgccg gtccgtgtcc gcgacggttg gcctgacctg gggaaagtgc
     9661 tgggccgacg ggtgacgaac gggcgaggcc agggtggtca aggcgatcaa cacggccaac
     9721 ggttcaccgg gcgccgacac cctccggctg gcccgcaagt gcacctacaa gctgacgtcc
     9781 ccgaacgcga ccgatcccgc gaacggcctg cccaccgtca ccagcgagat cacgatcgag
     9841 ggcaacggcg cgacgatcac gcgcgccaag tcggcctcgg acttccgcat cctgttggtg
     9901 ggcgcgtcgg gcaccctgat gctcaacagg accacgatca gcggcggccg ggcgacggac
     9961 tgccgctctt ccccggaggc gcggtctgcg ggggcggcat caacaaccag ggaaccctga
    10021 cggtgaacca cggcaaggtg gtccacaacg ccgccggctc cgccacggac ggcatcgtcg
    10081 tggagggcgg tggcatcgac agcgacggca ccgcagcgac ggcaccgcga ccgtgaacga
    10141 caccgacatc agtgacaaca ccgccatcta accggcagca ccgcgagcag tgccgacggc
    10201 ggcggactcg ccaacgacgg ccctctcacg ctcaagcgca gccgggtgac cggcaacatc
    10261 gtgcgcgtcg ccgagaacgc cggcagcttc gcgttcggcg ccggctacgc cgtcttcgcg
    10321 aagacgacca tcgaccacag caccatcagc ggcaaccgtg ccgacgcccc gcgcgggacc
    10381 gcgcgtggcg ctctggcgaa cgcctccccg gagggcatta cggtgaccga caccgtcatc
    10441 agccgcaacg ccaccagcgc tccgggcggc accg
//
