LOCUS       NZ_JACHGT010000018     12253 bp    DNA     linear   CON 26-SEP-2024
DEFINITION  Phytomonospora endophytica strain YIM 65646 Ga0310468_18, whole
            genome shotgun sequence.
ACCESSION   NZ_JACHGT010000018
VERSION     NZ_JACHGT010000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Phytomonospora endophytica
  ORGANISM  Phytomonospora endophytica
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Phytomonospora.
REFERENCE   1  (bases 1 to 203921)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 203921)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 173.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014202425.1-RS_2024_09_26
            Annotation Date                   :: 09/26/2024 09:39:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,840
            CDSs (total)                      :: 7,783
            Genes (coding)                    :: 7,704
            CDSs (with protein)               :: 7,704
            Genes (RNA)                       :: 57
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 79
            CDSs (without protein)            :: 79
            Pseudo Genes (ambiguous residues) :: 0 of 79
            Pseudo Genes (frameshifted)       :: 21 of 79
            Pseudo Genes (incomplete)         :: 67 of 79
            Pseudo Genes (internal stop)      :: 5 of 79
            Pseudo Genes (multiple problems)  :: 14 of 79
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:30:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 155155
            Orig. end                         :: 167408
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACHGT010000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12253
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12253
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12253
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7253](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7253
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(11..28)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     gene            238..1302
                     /locus_tag="HNR73_RS33000"
                     /old_locus_tag="HNR73_006734"
     CDS             238..1302
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HNR73_RS33000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HNR73_006734"
                     /product="hypothetical protein"
                     /protein_id="WP_184791699.1"
                     /transl_table=11
                     /translation="MTSDLDSACAELETAIADRDIDAFGQAMGLLWNAGQQAPAEELTA
                     ILPRCADILGTLHIGMGSQLALMCGAFAERGADPAPLVTPVAEGLREAMRRARLLRKAW
                     RAMGDPSPLPGEETTVEEYDAIVTALAASVGEEEARALAEGWDTLNLWQMPATSLLQLD
                     RSVRAAFPHRAEILEGCLELVDDQPSLSWLQGLLTVLDNEPLLVLHRPSGRGYEVTIAG
                     LGDNFQLHSLLAAALDGPVEEGLLGDLGLDPHWAAVATDAPPEDFGGTAEGRFNPADAT
                     GAWIWNEGRPADIPLFEDRRVVVLDPPSYPRSWNNDRQYPMMTGSLTLDRVLPEAEAAA
                     WLAKVGPAQDVPAV"
     gene            complement(1299..2195)
                     /locus_tag="HNR73_RS33005"
                     /old_locus_tag="HNR73_006735"
     CDS             complement(1299..2195)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019619.5"
                     /locus_tag="HNR73_RS33005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HNR73_006735"
                     /product="JmjC domain-containing protein"
                     /protein_id="WP_184791701.1"
                     /transl_table=11
                     /translation="MTTAVAATELFGPDGAIGRAWGTIPTVVRDGPLTALLPGADELLA
                     TPLLRPPFITVLDEGTPVAPSRYCRAEAFASPGRAEQIVDADALDGLLSAGAAVKFNRL
                     ELWSPAVAALASEIGAARGKKVKVWGFLSPHAQRLVPAHRDPAHVVAVQLDGRKGWILG
                     GPCPEEAWSAMKTPEPGEETRVELEAGDILYLPYGYAHCAAAETSSSFHISFALEGTTA
                     GELRHRIVKHVVDRLDGTDSTEVGEHNLAAIAAELHGVLDEAARAVAALPGRDGVERIH
                     AGDTAEVIDRLLGSDAP"
     gene            complement(2192..3502)
                     /locus_tag="HNR73_RS33010"
                     /old_locus_tag="HNR73_006736"
     CDS             complement(2192..3502)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.5"
                     /locus_tag="HNR73_RS33010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HNR73_006736"
                     /product="MFS transporter"
                     /protein_id="WP_311677837.1"
                     /transl_table=11
                     /translation="MTAGEESVETLEPPSPPVRRSLWRHRDFMLVWLGQSASMFGSTVS
                     FIALPLIGVLLLELSAFEMGLVATASTVPGVLLSPFSGTIVDRVDRRRLMIGADLGRAL
                     LIVSIPLATLFGVLSMAQLIVVGGGLAVLTRLFNLAHMTFLPSVVEEESLADGNSKLEA
                     SQSVADVSGPGAAGLLVTAVGPAVTVLVDAGSYVVSAVSLARVRFSSAASAAVKPRGRS
                     LKGFWRDTVTGFRLMWTDEVLRSISVSYASLALFAQIQMVVYMLFLVRNLHFPPIVIGL
                     VFALSGVVGFGAALLGGRLAGTLGVGRLLVLGQGAMVAGGVLLASVAGSTVQAAGTMLV
                     AEAFFAIGMSFWGVGSRTLFQIRTADEVRGRVIGASGVLTGVLVACSGLLGGALGSAFG
                     LRTALVIGAVGMLLSLALVLRRRVWMVHLDKTKVGQA"
     gene            complement(3499..4113)
                     /locus_tag="HNR73_RS33015"
                     /old_locus_tag="HNR73_006737"
     CDS             complement(3499..4113)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HNR73_RS33015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HNR73_006737"
                     /product="hypothetical protein"
                     /protein_id="WP_184791705.1"
                     /transl_table=11
                     /translation="MARAAHTLTDTRATRSLGRDDGVFHLGRPGWLTGELFDGLLRESR
                     EQRAGAEKIREQHFAELGPVGCSLRESDELRNYVETNAGVSATASGKGNYRYYDIPHSH
                     VVPHIDTDQFALNVIVMLEHDWVSERRSGLLLFPHGKDPVTVLLEVGEVILFYARRVIH
                     ARTPISDNNDERAVNLGIGFTPAGPVDAPEFWHPAEGWSPA"
     gene            4283..4438
                     /locus_tag="HNR73_RS33020"
                     /old_locus_tag="HNR73_006738"
     CDS             4283..4438
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HNR73_RS33020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HNR73_006738"
                     /product="hypothetical protein"
                     /protein_id="WP_184791707.1"
                     /transl_table=11
                     /translation="MFEEIEKANDGRELLIAPQNHPDARLSFVWDTTAGTEETFSEETA
                     TESDTV"
     misc_feature    complement(4460..4475)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     gene            4537..5004
                     /locus_tag="HNR73_RS33025"
                     /old_locus_tag="HNR73_006739"
     CDS             4537..5004
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013412.5"
                     /locus_tag="HNR73_RS33025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HNR73_006739"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_184791709.1"
                     /transl_table=11
                     /translation="MATWQEFAEQAPDIAELGLRIFTNYGIAYLGTIRADGGPRVVPVS
                     PVVVGDRIYIGVMPDTPKRHDLDRDPRCVVHSLPGPMDAEVCLTGTARQVSAEWVETLI
                     ATAPPNIRFARDTFVYEIDLERVNCTNFDNLVPGRRPRPTRSKWTAQGVAA"
     gene            5001..7253
                     /locus_tag="HNR73_RS41030"
                     /old_locus_tag="HNR73_006740"
     CDS             5001..7253
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="HNR73_RS41030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HNR73_006740"
                     /product="YcaO-like family protein"
                     /protein_id="WP_184791711.1"
                     /sec_met_domain="YcaO (E-value: 7.7e-60, bitscore: 196.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.4e-76, bitscore:
                     251.3, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRADRPRLVRVDAVAHPEGGMVLTTPRGRTFRLVLGERELAEVL
                     AACDGSTPVSEIVAGRERPAELASLVDMLTEEGCLSLKAPGPADADWARFAEADAAGPA
                     RTTVVVLGTGAFAATTVELLGRVGDRFGEVRTASSPNALTGLDPSATVVLACLDRFDPA
                     ELSRLERACASAGLRWSHFHFEAERGWFGPHHEPGGGPTFGDLHGRRLAATADPAALRA
                     RSQPAPGDAYLPPPHERFWMVSAFLVDVERWLAGAGPLGSWHEVELDPVDLGVERRPVL
                     PLPDAPPSSPPPGLFTDPAGPLTDRRLGIVTRLEKIPSHPLGPPGMTTVHAAGCNIGRI
                     SRWRNDPSGGGSSFGDPEAAAKAAVGELVERYCGNIVRADLLRRASHRELTRAGEHAVD
                     PERLALFSAAQYAAPGFPFAPMTRDTPIHWVRGRNLTRNVPAWLPASLVYVNWYKTSPE
                     DAPPTNGTAYAGVAAGVSLDDAVLSGLQEVVERHSTMVWWLNRPTLPAVVPSPRLAEAW
                     PNGTPDGPLRAWLIHLDNEFSIPVMAGVVEDADQGLFTIGFASRSDPEDAALKAWAEGL
                     TLQEIARDLAGPDNQYGRAVANGRLPDQGLKPWRADRRYLDDYRPDFRDVPTLICQTQV
                     HLDPRAVERIRPWVDVPLTRAVSDLPRLGGADLDTYRKAVEAPGYEVFYADITTPDVAA
                     AGLSVTRTLVPGLVGNFPAAFPFLGRGVVQDSAVRLGWRSEPRPEGDLTTIPIPHA"
     gene            7246..9396
                     /locus_tag="HNR73_RS33035"
                     /old_locus_tag="HNR73_006741"
     CDS             7246..9396
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014896.5"
                     /locus_tag="HNR73_RS33035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HNR73_006741"
                     /product="prolyl oligopeptidase family protein"
                     /protein_id="WP_184791713.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.2e-50, bitscore:
                     164.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSPAASGEAPFAHRDTTADMLHGVLVPDPYRWLEDRSSAATRSW
                     SADQDLHWSAVRDRLPGLDRWRAAVAEHLDVDYASAPIWRGRTRFEMRHTRGGTRPGLY
                     ATGPDGPARNLLDLLPPHLAAAAELHAWRPSPDGDRLALNLAVGGSEQAALYIMDVASG
                     RITDGPIEGCGHSSVAWFPCGRRLYYVRGGTDEAPRRGVYLHNVGADWRDDPQVYGGDQ
                     DRYYSVSVSPDGNWAAVSVTDGSAASGNELLLSDLRSAPPERPVPVQVQAPGTASSGIT
                     FGTDGLLYILTNREAPNRRIVVADPERPGHDGWRPLAGPDPGAVIVDFAIVGDHLLVSW
                     SRSALSEVSLHRLGDGERLREVPLPGEGKVGPLLTRAGDGDRAWFSYTDVTTSPRVVTY
                     RISTGLAESGTERPNRSQPTAVRTDRIRCVSADGTPIEMIMVRPRAAHGPISTILSGYG
                     GFGTSRPPTYSAATMAWLRAGGGYVSASLRGGGEHGETWHAAGRRHGKQNVIDDLLACA
                     RHLIDEGWTSRERLAVWGGSNGALVAAAAVTQDPDLFAAAVCTAPLCDMVRYESSGLGP
                     IWRSEYGTVADAEDFRHLLAYSPYHRVTDGRRYPATLFTVSEDDERVDPLHGRKMCAAL
                     QRASTGPGPVAIRRDRRVGHGNRALASTVAHTGDVLAFMAAHTGLLGLDEAASGGDDPG
                     LEAAGRVEAVEEFPRAAAERAS"
     gene            complement(9292..10008)
                     /locus_tag="HNR73_RS33040"
                     /old_locus_tag="HNR73_006742"
     CDS             complement(9292..10008)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HNR73_RS33040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HNR73_006742"
                     /product="hypothetical protein"
                     /protein_id="WP_184791715.1"
                     /transl_table=11
                     /translation="MNEHARRLTMFAAGYLQEAVLRIRRLFPDADGPRGGRAAEQVVND
                     VLIPHRPQPRGVTHRMMVAEGFGAIERMLLARLKCDDATGTGVRVIRSTDTAVSGAYDA
                     PPAARPVRSTPLELPFMVITPDKVVLGAERAVPAPPRLLVVGDQKALAELRACYDLLWW
                     AMSDDIRAEETHDPLPPDLLELLKELATGATDATAARNLHLSGRTLSRRARELLDSLDA
                     TSRFQAGIVAARRGLV"
     misc_feature    complement(9868..9870)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10153..11724)
                     /locus_tag="HNR73_RS33045"
                     /old_locus_tag="HNR73_006743"
     CDS             complement(10153..11724)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082267.1"
                     /locus_tag="HNR73_RS33045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HNR73_006743"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_184791717.1"
                     /transl_table=11
                     /translation="MDTDVVIAGGGPNGLMLACELALAGIRPLVLERLAEPSREPKANG
                     LLGQVVRLMDQRGLFESLSGGDGPPSPNRAYFMFGALPLDLSVLDDSPLYALPAPQHHI
                     VRVLDDRARELGVPVLRGHEVTGLSQDDDAVTVTVTGPDGPYTLRARHLVGADGAHSVT
                     RKLAGIEFPGVSYDRATVRSAHASLPAAWINPGSGALNVPGHGPVLPFLPHRTERGGFS
                     YAPLPGHPPLISTTEWEPPATTEPMTLAEMRASVARVLGADLPLEAPPGEGPHVLRRLA
                     GGNTRIAERFRDRRVFLVGDAAHVYAAGGGPGLNLGLQDAVNLGWKLAAALDGRAPDGL
                     LDTYETERRLAAERMVMNARAQSALIAPGPDVTGMRELFTELLGDPATVGRLAALTAGA
                     DVRYAITGEHPLTGTFAPDLALETPDGPTRLAELARSARPLLLDLTSNGSLAAALTEPP
                     VDVVTASAGPDAPTALLLRPDGYVAWASSAARPDPAELEKALGEWFTAAPADGRRDSRA
                     PGTSLH"
ORIGIN
        1 gcgaggtcga gatcctctcg accggctacc ccttcgccta catccgcggc gggcgcttcc
       61 tcgtcgtcgt caaccccgga cgcgacgccg tcaccctcga cgtgcccgcc ctcgcccgcg
      121 cggcgagccc ggtcgaggtc aagggcatca ccgtcgacgg cggccgcgtc gaggccgcgg
      181 gcttctccta cggcgtcttc gagctggcgc cctgagcccg gcggctacca tccgtcggtg
      241 acctcagacc tcgacagcgc gtgcgcggaa ctcgaaaccg ccatcgccga ccgcgacatc
      301 gacgccttcg gccaggccat gggcctgctg tggaacgccg gacagcaggc cccggccgaa
      361 gagctcaccg cgatcctgcc gcgctgcgcc gacatcctcg ggaccctcca catcggcatg
      421 ggcagccagc tcgcgctgat gtgcggggcc ttcgccgagc gcggcgccga cccggcaccg
      481 ctggtcacgc cggtcgccga aggcctgcgc gaggccatgc gacgcgcccg tctcctgcgc
      541 aaggcctggc gcgccatggg cgacccctcg ccgctgcccg gcgaggagac caccgtcgag
      601 gagtacgacg cgatcgtgac cgccctggcc gcctcggtcg gcgaggagga ggcccgcgcc
      661 ctcgccgagg gctgggacac cctcaacctc tggcagatgc cggcgacctc actgctccag
      721 ctcgacaggt ccgtccgcgc cgccttcccc caccgtgcgg agatcctcga aggctgcctc
      781 gaactcgtcg acgaccagcc ctccctgagc tggctgcaag gcctgctgac cgtcctcgac
      841 aacgagccgc tcctcgtcct gcaccgcccg agcggccgcg gctacgaggt caccatcgcc
      901 gggctcggcg acaacttcca gctgcactcc ctgctcgccg ccgcgctcga cgggcccgtc
      961 gaggagggcc tcctcggcga cctcggcctc gacccgcact gggccgccgt cgccaccgac
     1021 gcgccgcccg aggacttcgg cggaaccgcc gagggccgct tcaaccccgc cgacgccacc
     1081 ggcgcgtgga tctggaacga aggccgcccc gccgacatcc cgctcttcga ggaccgccgc
     1141 gtcgtcgtgc tcgacccgcc gtcctacccg cgctcgtgga acaacgaccg ccagtacccg
     1201 atgatgaccg gatccctgac gctcgaccgg gtcctgcccg aggccgaggc ggccgcgtgg
     1261 ctggccaagg tcgggccggc gcaggacgta ccggcggtct agggcgcgtc gctccccagc
     1321 aaccggtcga tgacctcggc ggtgtcgccg gcgtggatcc gctcgacacc gtccctgccc
     1381 ggcagcgcgg cgaccgcgcg ggcggcctcg tcgagcacgc cgtgcagttc ggcggcgatc
     1441 gcggccaggt tgtgctcacc gacctcggtg gagtcggtgc cgtcgagccg gtccacgacg
     1501 tgtttgacga tccggtggcg tagttccccg gcggtggttc cctccagcgc gaaggagatg
     1561 tggaacgacg aggaggtctc ggcggccgca caatgcgcgt agccgtaggg caggtacagg
     1621 atgtcgcccg cctccagctc gacccgggtc tcctcgccgg gctcgggcgt cttcatcgcc
     1681 gaccacgctt cctcggggca ggggccgccg agaatccagc ccttgcggcc gtcgagctgc
     1741 acggccacga cgtgcgccgg atcgcgatgt gcggggacga gccgctgggc gtgcggagac
     1801 aggaaacccc acaccttcac cttcttgccg cgggccgcgc cgatctccga ggccagcgcc
     1861 gccaccgccg gactccacag ttccagccgg ttgaacttga ccgccgcacc ggccgacagc
     1921 aggccgtcga gcgcatccgc gtcgacgatc tgctccgccc ggccggggct ggcgaaagcc
     1981 tccgcacggc agtaccggga cggcgccacg ggcgtgccct cgtcgaggac ggtgatgaac
     2041 ggtggccgca gcaagggcgt ggccaggagc tcgtccgcgc ccggcaggag cgccgtgaga
     2101 gggccgtccc ggacgaccgt cgggatcgtt ccccacgccc gcccgatcgc gccgtccggg
     2161 ccgaacagtt cggttgccgc gaccgccgtc gtcatgcctg acctaccttc gtcttgtcga
     2221 ggtgaaccat ccagacccgc cggcgcagca cgagcgcgag ggagaggagc atgccgacgg
     2281 caccgatcac cagcgccgtc cgcagcccga aggccgagcc gagcgcgccg ccgagcagtc
     2341 cggaacaggc gaccagcacg ccggtgagca ccccggaggc accgatgacc cggccccgga
     2401 cctcgtcggc ggtcctgatc tggaagaggg tccggctgcc cacgccccag aaggacatcc
     2461 cgatcgcgaa gaaggcctcg gcgaccagca tcgtcccggc ggcctggacc gtggaacccg
     2521 ccacggacgc cagcagcacc ccgcccgcga ccatggcgcc ctggccgagc accagcaggc
     2581 gcccgacgcc cagggtcccg gcgagacggc cgccgaggag ggccgcgccg aagcccacca
     2641 cgcccgacag ggcgaagacg aggccgatca cgatcggcgg gaagtgcaga ttgcggacca
     2701 ggaagagcat gtagacgacc atctggatct gcgcgaacag cgccagggag gcataggaga
     2761 cgctgatcga gcgcagcacc tcgtccgtcc acatcagccg aaagccggtc acggtgtcgc
     2821 gccagaaccc cttgaggctg cggccccgcg gtttaacggc ggcactcgcg gcggaggaga
     2881 acctcaccct cgccaggctg accgccgaga ccacatagga cccggcgtcg acgagaaccg
     2941 tcaccgccgg cccgaccgcg gtcaccagca gcccggccgc gccgggcccg ctgacgtcgg
     3001 cgaccgactg gctcgcctcc agcttgctgt tgccgtcggc gaggctctcc tcctcgacga
     3061 cactgggcag aaaggtcatg tgggccaggt tgaacaaccg ggtcagcacg gccagtcctc
     3121 cgccgaccac gatgagctgc gccatcgaca gcacgccgaa cagcgtcgcg agcggaatgg
     3181 acacgatcag caacgcgcgg cccaggtcgg cgccgatcat cagccgccgc cggtccaccc
     3241 ggtccacgat ggtccccgag aacgggctca gcagcacacc gggaacggtg ctcgcggtgg
     3301 ccacgaggcc catctcgaag gcgctgagct ccagcaggag cacaccgatg agcggcaggg
     3361 cgatgaagct gaccgtcgag ccgaacatcg acgccgactg gccgagccac acgagcatga
     3421 agtcacggtg cctccacaga ctccgccgca ccggcggaga agggggctcc agcgtctcca
     3481 cactctcctc accggccgtc acgcgggcga ccagccctcg gcggggtgcc agaactccgg
     3541 ggcgtcgacc ggcccggcgg gagtgaaccc gatgccgaga ttgaccgccc gctcgtcatt
     3601 gttgtccgag atcggagtgc gggcgtggat gacccggcgg gcatagaaca aaatgacctc
     3661 gccgacctcc agcagaaccg tcaccgggtc tttcccatgc gggaaaagca gcagacccga
     3721 gcgccgttca ctgacccaat catgctccag catcacgatc acgttgagcg cgaactggtc
     3781 ggtgtcgata tgcggcacga catgactgtg cggaatgtcg taataccggt agttcccttt
     3841 tccgctcgcg gtcgccgaaa ctccggcatt cgtctcgaca tagttgcgca gctcatccga
     3901 ctcgcgcagg gaacacccga ccggaccgag ttcggcgaag tgctgctcac ggatcttctc
     3961 ggctcccgcg cgctgctccc gcgattctcg caaaagcccg tcgaacagtt ccccggtaag
     4021 ccagccggga cggccgaggt gaaagacgcc gtcgtcgcgg cccaggctcc tggtcgctct
     4081 ggtatcggtc aacgtgtgag ctgccctggc cattcgtgcc tcccggtggc tcggcgaggg
     4141 tggactgcga ccgaagctac cgccctcacc gggctccggc ggcggccgtg gcgacaagtc
     4201 gccaaggaag atttcgacca cgccatcccc gcgatccccg gatacgttgg cgattcctca
     4261 ccaccagaaa agaggtgccg caatgttcga agagatcgaa aaggcgaacg acggccgtga
     4321 actgctgatc gcgccgcaga accaccccga cgcccgcctg tccttcgtat gggacaccac
     4381 ggccggcacc gaggagacct tctccgagga gacggcgacc gagtccgaca cggtctgaat
     4441 cagtcgcaag aactgaactg gttcgccagc ggcgagctgc gttcccacct cggaacgcag
     4501 ctcgctttca gccgacccat ccttgagggg agaaccatgg caacgtggca ggaattcgcc
     4561 gagcaggcac ccgacatcgc cgagctcgga cttcgcatct tcaccaatta cgggatcgcc
     4621 tacctcggca cgatccgcgc cgacggcgga ccccgcgtcg tgccggtctc gccggtggtc
     4681 gtcggcgacc ggatctacat cggcgtcatg cccgacaccc ccaagcgtca cgacctcgac
     4741 cgggacccgc gctgtgtcgt ccactccctg ccgggcccga tggacgccga ggtgtgcctc
     4801 accgggaccg cgcgccaggt gtccgccgaa tgggtcgaga ccctcatcgc caccgccccg
     4861 cccaacatcc gcttcgcgcg cgacaccttc gtctacgaga tcgacctgga acgggtcaac
     4921 tgcaccaact tcgacaacct cgtgcccggc cgccgaccac gccccacgcg atcgaagtgg
     4981 acggcacagg gcgtcgcggc gtgacccgcg ccgaccggcc acggctcgtc cgcgtcgacg
     5041 ccgtagccca tcccgaaggg ggcatggtcc tgaccacccc gcgcggaagg acgttccggc
     5101 tcgtcctcgg cgagcgagaa ctggccgagg tcctggccgc ctgcgacggc agcacgccgg
     5161 tcagcgagat cgtcgccggc cgcgagcgcc cggcggaact cgcgtctctt gtggacatgc
     5221 tgaccgagga gggttgtctc tccctcaagg ctcccggccc cgccgacgcc gactgggccc
     5281 gtttcgccga ggccgacgcc gccgggcccg cgcgcacgac ggtggtcgtg ctcggcaccg
     5341 gcgccttcgc ggccacgacc gtcgaacttc tcggccgggt cggcgaccgc ttcggcgagg
     5401 tccgaaccgc gtcctcacca aacgccctca ccggtctcga tccgtcggcc accgtcgtcc
     5461 tggcctgcct cgaccgcttc gacccggcgg aactgtcccg gctggagcga gcctgcgcgt
     5521 ccgcgggcct gcgatggagt cacttccact tcgaggcgga acggggatgg ttcggcccgc
     5581 accatgaacc gggcggcggg ccgaccttcg gtgacctcca cggccgccga ctggccgcca
     5641 cggcggatcc cgccgcgctg cgggcccgct cgcaaccggc gccgggtgac gcctacctgc
     5701 cgccgcccca cgagcgtttc tggatggtct cggccttcct cgtcgacgtc gaacgctggc
     5761 tcgccggcgc cgggcccctg ggctcctggc acgaggtcga gctggacccg gtcgatctgg
     5821 gcgtcgagcg ccgcccggta ctcccgctgc ccgacgcgcc gccgtcgtcg ccgccacccg
     5881 ggttgttcac cgatccggcc gggcccctga ccgaccggcg tctgggcatc gtcacccgcc
     5941 tggagaagat cccgtcgcac ccgctcgggc cacccgggat gaccaccgtc cacgcggcgg
     6001 gctgcaacat cgggcggatc agtcgctggc gcaacgatcc ctccggtgga gggagctcct
     6061 tcggcgatcc ggaagccgcc gcgaaggccg ccgtcggtga gctcgtggaa cgctactgcg
     6121 gcaacatcgt ccgggccgat ctgctgcgcc gggcgagcca ccgggagctg acacgggccg
     6181 gtgagcacgc cgtcgacccc gaacgcctgg cgttgttctc cgccgcccag tacgcggcac
     6241 ccgggttccc tttcgctccc atgacccgcg acacgccgat ccactgggtc cgcggccgca
     6301 acctgacccg gaacgtaccg gcgtggctgc cggccagcct cgtctatgtc aactggtaca
     6361 agacctctcc cgaggacgct cccccgacga acgggaccgc ctacgccggt gtcgcggcgg
     6421 gggtgagcct cgacgacgcc gtcctgtccg gtctgcagga ggtcgtggag cggcacagca
     6481 cgatggtctg gtggctcaac cggccgaccc tgcccgcagt ggtcccctcg ccacggctcg
     6541 ccgaggcctg gccgaacgga acaccggacg gtcccttgcg cgcgtggctg atccacctgg
     6601 acaacgagtt ctcgatcccg gtcatggcgg gcgtcgtcga ggacgccgac cagggtctgt
     6661 tcaccatcgg cttcgcctca cgctccgatc cggaggacgc ggccctgaag gcctgggccg
     6721 aaggcctgac gctgcaggag atcgcccgcg acctggcggg gcccgacaac cagtacggcc
     6781 gggccgtcgc caacgggcgt ctcccggacc agggactcaa gccgtggcgc gcggaccgtc
     6841 gctacctcga cgactaccgg ccggacttcc gcgacgtgcc caccctgatc tgccaaacgc
     6901 aggtccacct ggatccacgc gcggtggagc ggatccgccc ctgggtcgac gtcccactca
     6961 cccgtgccgt gtccgacctg ccgcgactcg gcggcgccga cctcgacacc taccgcaagg
     7021 ccgtcgaggc gcccggatac gaggtcttct acgccgacat caccactccc gacgtggccg
     7081 cggcgggcct gagcgtcacg cggacgctgg taccgggcct cgtcgggaac ttcccggcgg
     7141 ccttcccctt cctcggccgc ggtgtcgttc aggacagcgc cgtgcggctc ggctggcgct
     7201 ccgaacccag gcccgagggc gatctcacca cgattccgat tccccatgcc tagccccgcc
     7261 gcttcgggcg aggccccgtt cgcgcaccgg gacacgaccg ccgacatgct gcacggtgtc
     7321 ctggtcccgg acccctaccg gtggctggaa gaccggtcgt cggccgcgac ccgaagctgg
     7381 agcgccgacc aggatctgca ctggtcggcc gtccgcgaca ggctgccggg gctggaccgg
     7441 tggcgcgcgg ccgtcgccga acacctcgac gtcgactacg ccagcgcacc gatctggcgg
     7501 ggccgaacgc gcttcgagat gcgccacacg cgcggcggaa cgcggccggg gctgtacgcg
     7561 accggcccgg acgggccggc gcgcaatctt ctggacctgt tgccgccgca cctcgcggcc
     7621 gccgccgaac tgcacgcctg gagaccgtcg cccgatgggg accggctggc cctgaacctc
     7681 gccgtcggcg gttccgagca ggccgcgctg tacatcatgg acgtcgcctc cggccggatc
     7741 accgacggtc cgatcgaggg ctgcggccac tcctcggtcg cctggttccc ctgcggacgc
     7801 aggctgtact acgtccgcgg cggcaccgac gaggccccgc gacgcggggt ctacctgcac
     7861 aacgtcggcg ccgactggcg cgacgatcca caggtctacg gcggggacca agaccggtac
     7921 tactcggtgt cggtctcgcc cgacgggaac tgggcggcgg tgtcggtcac cgacgggagc
     7981 gccgcctccg gcaacgagct cctactctcc gacctgcggt ccgcaccgcc cgagcggccg
     8041 gtcccggtcc aggtgcaggc tcccggcacc gccagcagcg gcatcacctt cgggaccgac
     8101 ggtctgctgt acatcctcac caatcgggag gcgccgaacc ggcgcatcgt cgtcgccgat
     8161 cccgaacggc ccgggcacga cggctggcgc cccctcgccg gacccgatcc cggcgcggtc
     8221 atcgtcgatt tcgcgatcgt cggcgaccat ctcctggtgt cgtggagccg atcggcgctc
     8281 agcgaggtgt cgctgcaccg gctcggcgac ggcgagcgcc tgcgcgaggt gccgttgccg
     8341 ggcgagggca aggtcggccc ccttctcacc cgcgcgggcg acggtgatcg ggcgtggttc
     8401 agctacaccg acgtcacgac ctcaccgcgg gtcgtcacct accggatctc caccggtctc
     8461 gccgagagcg gcaccgagcg gccgaaccgg tcacagccga cggcggtgcg caccgaccgg
     8521 atccggtgcg tctcggccga cggcaccccc atcgagatga tcatggttcg gccgcgtgcc
     8581 gcacacggcc ccatctcgac gatcctgagc ggctacggcg gcttcggcac ctcccgcccg
     8641 ccgacctact cggcggccac catggcatgg ctccgcgcgg gcggcggcta tgtcagcgcg
     8701 agcctgcgcg gcggcggcga gcacggcgag acctggcacg cggcgggacg ccgccacggg
     8761 aagcagaacg tcatcgacga cctgctggcc tgcgcgcggc atctcatcga cgagggctgg
     8821 acgtcgcggg aacggctggc ggtctggggc ggcagcaacg gggccctcgt cgccgccgcc
     8881 gcggtgacac aggaccccga tctgttcgcc gcggcggtct gcaccgcgcc gctgtgcgac
     8941 atggtccgct acgagtcgtc gggcctgggc ccgatctggc gctcggagta cgggaccgtc
     9001 gccgacgccg aggacttccg gcacctgctc gcctactccc cctaccaccg cgtcaccgac
     9061 ggccgccgct atccggcgac gctgttcacc gtctccgagg acgacgagcg cgtcgatcca
     9121 ctgcacggcc gcaagatgtg cgcggccctc cagcgcgcga gcacgggtcc ggggccggtg
     9181 gcgatccggc gggaccgccg ggtcgggcac ggcaaccggg cgctggcgtc gaccgtcgcc
     9241 cacaccggcg acgtcctggc cttcatggcc gcccacaccg gactgctcgg gctagacgag
     9301 gccgcgtctg gcggcgacga tcccggcctg gaagcggctg gtcgcgtcga ggctgtcgag
     9361 gagttcccgc gcgcggcggc tgagcgtgcg tcctgatagg tgcaggttgc gcgcggccgt
     9421 cgcgtcggtg gctcccgtcg ccagttcctt gagtagttcc aggaggtccg ggggcagcgg
     9481 atcgtgcgtc tcttcggcgc gtatgtcgtc gctcatggcc caccacagca ggtcgtagca
     9541 ggcgcgcaac tcggcgaggg ccttctggtc gccgacgacc aggagccggg gcggcgccgg
     9601 cacggcgcgc tcggcgccga ggacgacctt gtcgggcgtg atcaccatga aggggagctc
     9661 cagcggcgtg ctgcgcaccg gccgcgcggc gggcggtgcg tcgtaggcgc cggacaccgc
     9721 cgtgtcggtc gagcggatga cccgcacacc ggtcccggtg gcgtcgtcgc acttgagtct
     9781 ggcgagcagc atccgttcga tggcgccgaa cccctcggcg accatcatcc ggtgggtgac
     9841 cccgcgcggc tgggggcgat gcgggattaa gacgtcgttg acgacctgct cggcggcccg
     9901 cccaccgcgc gggccgtcgg cgtcggggaa gagccgccgg atccgcagca ccgcctcctg
     9961 cagataaccc gccgcgaaca tcgtcagccg ccgagcatgt tcgttcatgt ctctcccgct
    10021 cccctcgcac cgcgaccgat tccgcctcgc cggtccacgt ggtcaccact gtgaccggac
    10081 cgcctcgccg aaaccttgag cggaacttgg tcgcggcttg aagcgcgagc gcggaccgga
    10141 tcaccggtga ggtcagtgaa gcgaggttcc gggcgcgcgg ctgtcccgtc ggccgtccgc
    10201 cggggccgcg gtgaaccact cccccaaggc cttctccaac tcggccggat cgggccgggc
    10261 cgccgaggag gcccaggcca cgtacccgtc cgggcgcagg agcagcgcgg tcggcgcgtc
    10321 gggcccggcg ctcgccgtga cgacgtcgac gggcggctcg gtgagcgcgg cggcgaggga
    10381 gccgttgctg gtcaggtcga ggaggagggg ccgggccgag cgggcgagtt cggcgaggcg
    10441 ggtggggccg tcgggggtct ccagggcaag gtcgggggcg aaggttccgg tcagcgggtg
    10501 ttcgccggtg atggcgtagc ggacgtcggc accggcggtg agtgcggcga ggcgtccgac
    10561 cgtggcgggg tcgccgagca gttcggtgaa cagctcgcgc atgccggtga cgtcggggcc
    10621 gggtgcgatg agggccgact gggcccgggc gttcatcacc atgcgttcgg cggcgaggcg
    10681 ccgttcggtc tcgtaggtgt cgaggagccc gtcgggggcg cggccgtcga gggcggcggc
    10741 gagtttccag ccgaggttga ccgcgtcctg gaggccgagg ttgagtccgg gtccgccacc
    10801 ggcggcgtag acgtgggcgg cgtcgccgac gaggaacacg cggcggtcgc ggaagcgctc
    10861 ggcgatgcgg gtgttgcctc cggcgaggcg ccgcagcacg tgcggtcctt cgccaggcgg
    10921 tgcttcgagg ggcaggtcgg cgccgaggac gcgggcgacg ctcgcgcgca tctcggcgag
    10981 ggtcatcggc tcggtcgtcg caggcggctc ccactcggtc gtgctgatca gcggggggtg
    11041 cccgggcagc ggcgcgtagg agaagccgcc gcgttcggtc cggtgcggca ggaacggcag
    11101 gacgggcccg tgcccgggca cgttcagtgc cccgctgccg ggattgatcc acgccgccgg
    11161 gaggctcgcg tgggcagagc ggacggtcgc gcgatcgtag gagacgccgg ggaactcgat
    11221 gcccgcgagc ttgcgggtca cgctgtgggc tccgtcggcg ccgacgaggt ggcgcgcccg
    11281 cagcgtgtag ggaccgtccg gtccggtgac cgtgacggtc acggcgtcgt cgtcctggga
    11341 aaggccggtg acctcgtgcc cgcgcaggac cggcacaccc agttcgcggg cgcggtcgtc
    11401 gaggacgcgc acgatgtggt gctgtggggc gggaagggcg tagagggggc tgtcgtcgag
    11461 gacgctgagg tcgaggggca gcgcgccgaa catgaagtag gcccggttcg gtgacggcgg
    11521 gccgtcgccg ccgctcaagg attcgaacag tccgcgctgg tccatcaggc gcacgacctg
    11581 gccgagcagt ccgttggcct tcggttcgcg gctcggttcg gccagccgct ccagcacgag
    11641 cggccggatc ccggcgaggg cgagttcgca ggccagcatc aggccgttgg gtccgcctcc
    11701 ggcgatgacg acgtcggtgt ccatgtgggt ttcctcgttt cagggcaggg gtgagcggcc
    11761 cggcggtcgc cgggctgcgt tgggcgagat gggggttagg gggtggggag gccggcgcgc
    11821 aggccgtcga agacctcgcg caggagcggc ccgagcggtg gcgggtcgtc ggcccggagg
    11881 cagtgttcga cggcggtggc actggccgcg ccgacgacgg cggcgacgag cttggggtag
    11941 acgtcgcggg tcacgtcggt gccggtccgt tcggcgacga cggcggcgag agcgtcctgg
    12001 gcggcggcgt tggccttgag gatctcgccc tgcagcgcgg gttcggcgaa gaggagcatc
    12061 agcgcgtccc gccagcggcg gtcggccggg gatccgccgg tgccgtcggc gggggcgaac
    12121 tgggcgtgga ccgcgccggc gagggagtcc cacaggggct cgtcggcggg gcgggcgcgg
    12181 agttcgtcgg cgatgcgcat ggcgcgttcg acgtggctgg cggcgatcgc ctcggccttg
    12241 ccggagaagt agt
//
