GCF_014195725.1 - 11 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JACICH010000001.1 (Xanthomonas euroxanthea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lassopeptide	1,110,927	1,133,334	High	xanthomonin II/xanthomonin I	ribosomal:RiPP:Lasso peptide

NZ_JACICH010000002.1 (Xanthomonas euroxanthea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	terpene-precursor	605,919	626,794
Region 2.2	redox-cofactor	978,179	1,000,306
Region 2.3	NI-siderophore	1,047,346	1,080,097	High	xanthoferrin	other:other

NZ_JACICH010000005.1 (Xanthomonas euroxanthea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	t3nrps-iterative,NRPS	7,246	54,009
Region 5.2	arylpolyene	174,808	216,004	Medium	xanthomonadin I	other:other

NZ_JACICH010000006.1 (Xanthomonas euroxanthea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	NRPS-like	1	20,755	Low	myxovalargin A	NRPS:Type I

NZ_JACICH010000010.1 (Xanthomonas euroxanthea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	NRPS	1	10,843

NZ_JACICH010000013.1 (Xanthomonas euroxanthea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	NRPS	1	4,969

NZ_JACICH010000014.1 (Xanthomonas euroxanthea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	NRPS	1	4,754

NZ_JACICH010000015.1 (Xanthomonas euroxanthea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	NRPS	1	2,516

No secondary metabolite regions were found in these records:: NZ_JACICH010000003.1 (Xanthomonas euroxanthea); NZ_JACICH010000004.1 (Xanthomonas euroxanthea); NZ_JACICH010000007.1 (Xanthomonas euroxanthea); NZ_JACICH010000008.1 (Xanthomonas euroxanthea); NZ_JACICH010000009.1 (Xanthomonas euroxanthea); NZ_JACICH010000011.1 (Xanthomonas euroxanthea); NZ_JACICH010000012.1 (Xanthomonas euroxanthea); NZ_JACICH010000016.1 (Xanthomonas euroxanthea); NZ_JACICH010000017.1 (Xanthomonas euroxanthea); NZ_JACICH010000018.1 (Xanthomonas euroxanthea); NZ_JACICH010000019.1 (Xanthomonas euroxanthea); NZ_JACICH010000020.1 (Xanthomonas euroxanthea)

Compact view

NZ_JACICH010000001.1 - Region 1 - lassopeptide

Download region GenBank file

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Location: 1,110,927 - 1,133,334 nt. (total: 22,408 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FHY13_RS04825: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

FHY13_RS04830: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

FHY13_RS04855: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000580.3	0.88	ribosomal	xanthomonin II, xanthomonin I	Xanthomonas gardneri ATCC 19865
BGC0000570.3	0.63	ribosomal	astexin-1	Asticcacaulis excentricus CB 48
BGC0000573.3	0.60	ribosomal	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0001786.3	0.60	ribosomal	subterisin	Novosphingobium subterraneum
BGC0000574.3	0.58	ribosomal	caulosegnin I, caulosegnin II, caulosegnin III	Caulobacter segnis ATCC 21756
BGC0000577.3	0.57	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0000576.3	0.57	ribosomal	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0002633.2	0.43	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002403.2	0.42	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0000820.5	0.40	other (other)	physostigmine	Streptomyces griseofuscus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000580.3	0.88	ribosomal	xanthomonin II, xanthomonin I	Xanthomonas gardneri ATCC 19865
BGC0000570.3	0.63	ribosomal	astexin-1	Asticcacaulis excentricus CB 48
BGC0000573.3	0.60	ribosomal	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0001786.3	0.60	ribosomal	subterisin	Novosphingobium subterraneum
BGC0000574.3	0.58	ribosomal	caulosegnin I, caulosegnin II, caulosegnin III	Caulobacter segnis ATCC 21756
BGC0000577.3	0.57	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0000576.3	0.57	ribosomal	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0002633.2	0.43	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002403.2	0.42	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0000820.5	0.40	other (other)	physostigmine	Streptomyces griseofuscus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for FHY13_RS04840

FHY13_RS04840

Leader:

MNINDTTHSDASSEITVLGVASTDTK

Full core:

GGPLAGEEIGGFNVPG

Putative macrolactam:

GGPLAGEE

FHY13_RS04840

Cleaved off residues:

ISEE

antiSMASH-DB 4.0 matches for FHY13_RS04840

100.0%

NZ_CM002307.1and 56 others:

NZ_CP011256.1 Lassopeptides: XB05_RS24520_lassopeptideNZ_CP012251.1 Lassopeptides: AKJ12_RS23425_lassopeptideNZ_CP016878.1 Lassopeptides: XJ27_RS23915_lassopeptideNZ_CP018728.1 Lassopeptides: BJD10_RS25145_lassopeptideNZ_CP029263.1 Lassopeptides: DGN21_RS02930_lassopeptideNZ_CP044334.1 Lassopeptides: F6Y24_RS09085_lassopeptideNZ_CP062164.1 Lassopeptides: ICA18_RS02860_lassopeptideNZ_CP076534.1 Lassopeptides: KPG65_RS08545_lassopeptideNZ_CP098604.1 Lassopeptides: NDY25_RS14310_lassopeptideNZ_CP101417.1 Lassopeptides: NMB96_RS02310_lassopeptideNZ_CP107241.1 Lassopeptides: OEG85_RS03720_lassopeptideNZ_HG999362.1 Lassopeptides: KHN93_RS03315_lassopeptideNZ_HG999363.1 Lassopeptides: KHN77_RS02995_lassopeptideNZ_HG999364.1 Lassopeptides: KHO05_RS03095_lassopeptideNZ_JAASRA010000001.1 Lassopeptides: FHY35_RS01405_lassopeptideNZ_JAASRB010000002.1 Lassopeptides: FHT12_RS12290_lassopeptideNZ_JAASRF010000002.1 Lassopeptides: FHR48_RS06095_lassopeptideNZ_JAASRG010000002.1 Lassopeptides: FHY20_RS09925_lassopeptideNZ_JAASRJ010000002.1 Lassopeptides: FHY12_RS12975_lassopeptideNZ_JAASRK010000002.1 Lassopeptides: FHY11_RS09760_lassopeptideNZ_JAASRL010000003.1 Lassopeptides: FHY10_RS16380_lassopeptideNZ_JAATIU010000002.1 Lassopeptides: GGR60_RS11030_lassopeptideNZ_JAATIV010000002.1 Lassopeptides: GGR63_RS15750_lassopeptideNZ_JAATIY010000001.1 Lassopeptides: GGR72_RS06800_lassopeptideNZ_JACHNM010000002.1 Lassopeptides: FHY34_RS11015_lassopeptideNZ_JACHNN010000001.1 Lassopeptides: FHT07_RS03800_lassopeptideNZ_JACHNO010000002.1 Lassopeptides: FHT09_RS10540_lassopeptideNZ_JACHNQ010000001.1 Lassopeptides: FHR57_RS03345_lassopeptideNZ_JACHNR010000001.1 Lassopeptides: FHR58_RS07330_lassopeptideNZ_JACHNS010000004.1 Lassopeptides: FHR60_RS13510_lassopeptideNZ_JACHNT010000007.1 Lassopeptides: FHR62_RS17675_lassopeptideNZ_JACHOE010000002.1 Lassopeptides: GGR59_RS09535_lassopeptideNZ_JACHOI010000001.1 Lassopeptides: GGR67_RS03770_lassopeptideNZ_JACICH010000001.1 Lassopeptides: FHY13_RS04840_lassopeptideNZ_JACICI010000001.1 Lassopeptides: FHY16_RS03570_lassopeptideNZ_JACICJ010000002.1 Lassopeptides: FHY17_RS09150_lassopeptideNZ_JACIIP010000002.1 Lassopeptides: FHR64_RS08920_lassopeptideNZ_JACIIQ010000008.1 Lassopeptides: FHR65_RS11870_lassopeptideNZ_JACIIT010000002.1 Lassopeptides: FHT05_RS08405_lassopeptideNZ_JACIJV010000001.1 Lassopeptides: FHR59_RS03435_lassopeptideNZ_JZEF01000002.1 Lassopeptides: XARJCFBP2528_RS23390_lassopeptideNZ_JZEG01000001.1 Lassopeptides: XARJCFBP7179_RS23550_lassopeptideNZ_JZEH01000001.1 Lassopeptides: XARJCFBP7634_RS22250_lassopeptideNZ_JZEI01000001.1 Lassopeptides: XARJCFBP7651_RS22545_lassopeptideNZ_KL638866.1 Lassopeptides: IA64_RS22220_lassopeptideNZ_KL638873.1 Lassopeptides: GW16_RS22410_lassopeptideNZ_LMOG01000002.1 Lassopeptides: ASF73_RS22605_lassopeptideNZ_LR861803.1 Lassopeptides: H7A86_RS02980_lassopeptideNZ_LR861807.1 Lassopeptides: H5027_RS18790_lassopeptideNZ_LR990736.1 Lassopeptides: LMG31887_RS03570_lassopeptideNZ_LR990739.1 Lassopeptides: KC661_RS03500_lassopeptideNZ_LR994544.1 Lassopeptides: XTG_RS03110_lassopeptideNZ_PUPR01000001.1 Lassopeptides: C0535_RS05675_lassopeptideNZ_QREQ01000002.1 Lassopeptides: C0538_RS11855_lassopeptideNZ_QRER01000001.1 Lassopeptides: C0539_RS04405_lassopeptideNZ_VCME01000014.1 Lassopeptides: FFY45_RS13360_lassopeptide

Lassopeptides: XHC_RS22885_lassopeptide

1

GGPLAGEEIGGFNVPG

16

GGPLAGEEIGGFNVPG

1

GGPLAGEEIGGFNVPG

16

68.8%

NZ_CM002307.1and 32 others:

NZ_CP011256.1 Lassopeptides: XB05_RS24515_lassopeptideNZ_CP012251.1 Lassopeptides: AKJ12_RS23430_lassopeptideNZ_CP016878.1 Lassopeptides: XJ27_RS23910_lassopeptideNZ_CP018728.1 Lassopeptides: BJD10_RS25150_lassopeptideNZ_CP098604.1 Lassopeptides: NDY25_RS14305_lassopeptideNZ_CP101417.1 Lassopeptides: NMB96_RS02315_lassopeptideNZ_CP107241.1 Lassopeptides: OEG85_RS03715_lassopeptideNZ_HG999363.1 Lassopeptides: KHN77_RS02990_lassopeptideNZ_HG999364.1 Lassopeptides: KHO05_RS03090_lassopeptideNZ_JAASRB010000002.1 Lassopeptides: FHT12_RS12285_lassopeptideNZ_JAASRJ010000002.1 Lassopeptides: FHY12_RS12980_lassopeptideNZ_JAASRK010000002.1 Lassopeptides: FHY11_RS09765_lassopeptideNZ_JAATIU010000002.1 Lassopeptides: GGR60_RS11025_lassopeptideNZ_JAATIV010000002.1 Lassopeptides: GGR63_RS15745_lassopeptideNZ_JACHNM010000002.1 Lassopeptides: FHY34_RS11010_lassopeptideNZ_JACHNO010000002.1 Lassopeptides: FHT09_RS10545_lassopeptideNZ_JACHOE010000002.1 Lassopeptides: GGR59_RS09540_lassopeptideNZ_JACHOI010000001.1 Lassopeptides: GGR67_RS03765_lassopeptideNZ_JACICH010000001.1 Lassopeptides: FHY13_RS04845_lassopeptideNZ_JACICI010000001.1 Lassopeptides: FHY16_RS03565_lassopeptideNZ_JACICJ010000002.1 Lassopeptides: FHY17_RS09145_lassopeptideNZ_JACIIT010000002.1 Lassopeptides: FHT05_RS08410_lassopeptideNZ_JZEH01000001.1 Lassopeptides: XARJCFBP7634_RS22255_lassopeptideNZ_JZEI01000001.1 Lassopeptides: XARJCFBP7651_RS22540_lassopeptideNZ_KL638873.1 Lassopeptides: GW16_RS22405_lassopeptideNZ_LR861803.1 Lassopeptides: H7A86_RS02975_lassopeptideNZ_LR990736.1 Lassopeptides: LMG31887_RS03565_lassopeptideNZ_LR990739.1 Lassopeptides: KC661_RS03495_lassopeptideNZ_LR994544.1 Lassopeptides: XTG_RS03105_lassopeptideNZ_QREQ01000002.1 Lassopeptides: C0538_RS11850_lassopeptideNZ_QRER01000001.1 Lassopeptides: C0539_RS04400_lassopeptideNZ_VCME01000014.1 Lassopeptides: FFY45_RS13365_lassopeptide

Lassopeptides: XHC_RS22890_lassopeptide

1

GGPLAGEEIGGFNVPG

16

GGPLAGEE+GG G

1

GGPLAGEEMGGITTLG

16

68.8%

NZ_CP029263.1and 18 others:

NZ_CP044334.1 Lassopeptides: F6Y24_RS09090_lassopeptideNZ_CP062164.1 Lassopeptides: ICA18_RS02855_lassopeptideNZ_HG999362.1 Lassopeptides: KHN93_RS03310_lassopeptideNZ_JAASRA010000001.1 Lassopeptides: FHY35_RS01400_lassopeptideNZ_JAASRL010000003.1 Lassopeptides: FHY10_RS16375_lassopeptideNZ_JAATIY010000001.1 Lassopeptides: GGR72_RS06805_lassopeptideNZ_JACHNN010000001.1 Lassopeptides: FHT07_RS03795_lassopeptideNZ_JACHNQ010000001.1 Lassopeptides: FHR57_RS03340_lassopeptideNZ_JACHNR010000001.1 Lassopeptides: FHR58_RS07335_lassopeptideNZ_JACHNT010000007.1 Lassopeptides: FHR62_RS17680_lassopeptideNZ_JACIIP010000002.1 Lassopeptides: FHR64_RS08915_lassopeptideNZ_JACIIQ010000008.1 Lassopeptides: FHR65_RS11875_lassopeptideNZ_JACIJV010000001.1 Lassopeptides: FHR59_RS03430_lassopeptideNZ_JZEF01000002.1 Lassopeptides: XARJCFBP2528_RS23385_lassopeptideNZ_JZEG01000001.1 Lassopeptides: XARJCFBP7179_RS23555_lassopeptideNZ_KL638866.1 Lassopeptides: IA64_RS22225_lassopeptideNZ_LR861807.1 Lassopeptides: H5027_RS18795_lassopeptideNZ_PUPR01000001.1 Lassopeptides: C0535_RS05670_lassopeptide

Lassopeptides: DGN21_RS02925_lassopeptide

1

GGPLAGEEIGGFNVPG

16

GGPLAGEE+GG G

1

GGPLAGEEMGGSTTLG

16

with 9 more sequence matches

68.8%

NZ_LMOG01000002.1:

Lassopeptides: ASF73_RS22610_lassopeptide

1

GGPLAGEEIGGFNVPG

16

GGPLAGEE+GG G

1

GGPLAGEEMGGTTTLG

16

62.5%

NZ_CP076534.1:

Lassopeptides: KPG65_RS08540_lassopeptide

2

GPLAGEEIGGFNVPG

16

GPLAGEE+GG G

2

GPLAGEEMGGSTTLG

16

62.5%

NZ_JAASRF010000002.1and 2 others:

NZ_JAASRG010000002.1 Lassopeptides: FHY20_RS09930_lassopeptideNZ_JACHNS010000004.1 Lassopeptides: FHR60_RS13505_lassopeptide

Lassopeptides: FHR48_RS06090_lassopeptide

1

GGPLAGEEIGGFNVPG

16

GGPL+GEE+GG G

1

GGPLSGEEMGGTATLG

16

62.5%

NZ_JACHCO010000003.1:

Lassopeptides: HDE79_RS09305_lassopeptide

1

GGPLAGEEIGGFNVPG

16

GGPL E IGGF G

1

GGPLMNEVIGGFTTSG

16

62.5%

NZ_JACHCP010000001.1:

Lassopeptides: HDE80_RS00035_lassopeptide

1

GGPLAGEEIGGFNVPG

16

GGPL E IGGF G

1

GGPLMNEVIGGFTTAG

16

56.2%

NZ_CP089507.1:

Lassopeptides: LU699_RS12715_lassopeptide

1

GGPLAGEEIGGFNVPG

16

GG L GE+IG +PG

1

GGALVGEDIGDPFIPG

16

50.0%

NZ_CP017074.1:

Lassopeptides: BGP89_RS14250_lassopeptide

1

GGPLAGEEIGGFNVPG

16

G L GE++GG PG

1

GSALIGEDVGGRYTPG

16

50.0%

NZ_CP042218.1:

Lassopeptides: FPZ22_RS13815_lassopeptide

1

GGPLAGEEIGGF

12

GG L GE++GGF

1

GGTLIGEDMGGF

12

50.0%

NZ_CP089507.1:

Lassopeptides: LU699_RS12710_lassopeptide

1

GGPLAGEEIGGFNVPG

16

GG L GE++G +PG

1

GGALLGEDMGNTTMPG

16

MIBiG 4.0 matches for FHY13_RS04840

80.0%

BGC0000580.3 (EGD17354.1):

Lasso peptide: xanthomonin II or xanthomonin I

1

GGPLAGEEIGGFNVPG

16

GGPLAGEEIGGFNVPG

1

GGPLAGEEIGGFNVPG

16

55.0%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

1

GGPLAGEEIGGFNVPG

16

GGPLAGEE+GG G

1

GGPLAGEEMGGITTLG

16

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.78 out of 29.72

Confidence: medium

Additional weak hits (6):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.67 out of 20.01

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.06 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.43 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.59 out of 26.06

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.81 out of 20.01

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 20.28 out of 36.54

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

FHY13_RS04840 - Class II: Cleavage pHMM score: 9.50; RODEO score: 22; Monoisotopic mass: 1451.7 Da; Molecular weight: 1452.6 Da; Number of bridges: 0

RRE predictions

: RRE type: Lasso_Fused_RRE; Location: 3 - 66; Score: 64.9

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence

NZ_JACICH010000002.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 605,919 - 626,794 nt. (total: 20,876 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

FHY13_RS10840: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000643.3	0.33	terpene	carotenoid	Brevundimonas vesicularis
BGC0000640.3	0.32	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000634.3	0.32	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000630.3	0.31	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.31	terpene	β-carotein	uncultured bacterium
BGC0000639.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000643.3	0.33	terpene	carotenoid	Brevundimonas vesicularis
BGC0000640.3	0.32	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000634.3	0.32	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000630.3	0.31	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.31	terpene	β-carotein	uncultured bacterium
BGC0000639.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FHY13_RS10840: PT_FPPS_like

Domain 1 (31 - 291): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.96 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.01 out of 27.78

Confidence: medium

Additional weak hits (10):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.22 out of 30.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.42 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.63 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.51 out of 30.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.17 out of 18.57

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.32 out of 27.78

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.43 out of 24.78

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.90 out of 20.01

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.13 out of 27.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.37 out of 29.65

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator

NZ_JACICH010000002.1 - Region 2 - redox-cofactor

Download region GenBank file

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Location: 978,179 - 1,000,306 nt. (total: 22,128 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase

FHY13_RS12395: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001100.5	0.34	NRPS, PKS	lankacidin C	Streptomyces rochei
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000906.3	0.30	other (other)	heme D1	Heliophilum fasciatum
BGC0000905.5	0.30	other (other)	heme D1	Heliobacillus mobilis
BGC0000461.5	0.29	NRPS	WAP-8294A2	Lysobacter enzymogenes
BGC0000796.3	0.25	saccharide	S-layer glycan	Paenibacillus alvei
BGC0000768.5	0.23	saccharide	gellan polysaccharide	Sphingomonas elodea ATCC 31461

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001100.5	0.34	NRPS, PKS	lankacidin C	Streptomyces rochei
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000906.3	0.30	other (other)	heme D1	Heliophilum fasciatum
BGC0000905.5	0.30	other (other)	heme D1	Heliobacillus mobilis
BGC0000461.5	0.29	NRPS	WAP-8294A2	Lysobacter enzymogenes
BGC0000796.3	0.25	saccharide	S-layer glycan	Paenibacillus alvei
BGC0000768.5	0.23	saccharide	gellan polysaccharide	Sphingomonas elodea ATCC 31461

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.19 out of 20.47

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

Additional weak hits (6):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.21 out of 20.01

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.08 out of 30.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.85 out of 26.12

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.45 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.87 out of 32.93

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 1 - 91; Score: 116.6

TFBS definitions

Regulator	Description
MexT	Global virulence regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_JACICH010000002.1 - Region 3 - NI-siderophore

Download region GenBank file

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Location: 1,047,346 - 1,080,097 nt. (total: 32,752 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Select a gene to view the details available for it

Gene overview

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

FHY13_RS12685: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: sulfhydrylase

FHY13_RS12750: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

Lyases: decarboxylase

FHY13_RS12725: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001408.5	0.87	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2	0.80	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0000946.5	0.79	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0000947.5	0.62	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0000844.5	0.49	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0000943.5	0.49	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002681.3	0.48	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4
BGC0002692.2	0.47	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.47	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001408.5	0.87	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2	0.80	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0000946.5	0.79	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0000947.5	0.62	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0000844.5	0.49	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0000943.5	0.49	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002681.3	0.48	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4
BGC0002692.2	0.47	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.47	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.00 out of 28.19

Confidence: medium

Additional weak hits (9):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.84 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.12 out of 26.06

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.29 out of 20.97

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.46 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.56 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.50 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.21 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.78 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.38 out of 30.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MexT	Global virulence regulator
ZuR variant 1	Zinc-responsive repressor

NZ_JACICH010000005.1 - Region 1 - NRPS,t3nrps-iterative

Download region GenBank file

Download region SVG

Location: 7,246 - 54,009 nt. (total: 46,764 nt) Show pHMM detection rules used

t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FHY13_RS15980: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase glycosyltransferase

FHY13_RS15985: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

FHY13_RS15990: glycosyltransferase

smcogs: SMCOG1102: glycosyltransferase

Lyases: decarboxylase dehydratase

FHY13_RS15925: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

FHY13_RS16000: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase synthase

FHY13_RS15930: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

FHY13_RS15995: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.87	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.67	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.59	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.67	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46

Confidence: strong

Additional weak hits (22):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.34 out of 21.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.62 out of 30.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.90 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.89 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.35 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.33 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.98 out of 29.38

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.99 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.23 out of 26.06

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.25 out of 30.97

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.04 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.76 out of 26.06

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.84 out of 26.33

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.31 out of 27.78

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.34 out of 20.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.08 out of 28.19

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.34 out of 32.93

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.45 out of 35.63

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.63 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 7245 - 54009:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FHY13_RS15995: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (465..852): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDIAGLELQALVGGETQLYGPTETTIWSTI
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

NZ_JACICH010000005.1 - Region 2 - arylpolyene

Download region GenBank file

Download region SVG

Location: 174,808 - 216,004 nt. (total: 41,197 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FHY13_RS16740: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase halogenase

FHY13_RS16730: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

FHY13_RS16775: acyltransferase

smcogs: SMCOG1141: acyltransferase

FHY13_RS16790: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

Ligases: ligase synthase

FHY13_RS16715: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

FHY13_RS16725: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

FHY13_RS16805: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000840.5	0.76	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0000866.5	0.50	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002643.2	0.48	other (other)	aetokthonotoxin	Aetokthonos hydrillicola Thurmond2011
BGC0000867.3	0.48	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001987.2	0.46	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001366.5	0.44	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002008.3	0.44	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0001940.3	0.43	PKS	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0001075.5	0.43	PKS, terpene	aurachin RE	Rhodococcus erythropolis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000840.5	0.76	other (other)	xanthomonadin I	Xanthomonas oryzae pv. oryzae
BGC0000866.5	0.50	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002643.2	0.48	other (other)	aetokthonotoxin	Aetokthonos hydrillicola Thurmond2011
BGC0000867.3	0.48	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001987.2	0.46	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001366.5	0.44	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002008.3	0.44	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0001940.3	0.43	PKS	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0001075.5	0.43	PKS, terpene	aurachin RE	Rhodococcus erythropolis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.75 out of 23.79

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

Additional weak hits (6):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.87 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.11 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.65 out of 29.38

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.00 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.19 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.05 out of 24.78

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

FHY13_RS16805: X

AMP-binding (39..308): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TPQV-------LVTVSATAREMFGSTETCVFAVR
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
AfsR	Pleiotropic regulatory for antibiotic production
IolR	Regulator of the inositol catabolism

NZ_JACICH010000006.1 - Region 1 - NRPS-like

Download region GenBank file

Download region SVG

Location: 1 - 20,755 nt. (total: 20,755 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

FHY13_RS17355: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: phosphatase

FHY13_RS17320: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	0.63	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000308.5	0.46	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001168.5	0.43	NRPS	Livipeptin	Streptomyces lividans 1326
BGC0000393.5	0.43	NRPS, PKS	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0001768.4	0.41	NRPS	sansalvamide	[Nectria] haematococca mpVI 77-13-4
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	0.63	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000308.5	0.46	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001168.5	0.43	NRPS	Livipeptin	Streptomyces lividans 1326
BGC0000393.5	0.43	NRPS, PKS	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0001768.4	0.41	NRPS	sansalvamide	[Nectria] haematococca mpVI 77-13-4
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.60 out of 23.79

Confidence: medium

Additional weak hits (4):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.83 out of 21.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.57 out of 27.78

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.91 out of 35.63

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_JACICH010000010.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 10,843 nt. (total: 10,843 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

FHY13_RS19945: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

FHY13_RS19950: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FHY13_RS19960: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.64	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.64	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed domain annotation

Selected features only

Show module domains

NZ_JACICH010000013.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 4,969 nt. (total: 4,969 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

FHY13_RS20005: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 4969:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FHY13_RS20005: Phe

Search NORINE for peptide: strict or relaxed

AMP-binding (552..944): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LQQAFDASVFEMTLVSAGEFNAYGPTEATVWSTW
Nearest Stachelhaus code(s):: Phe DAFTVAAVWK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

NZ_JACICH010000014.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 4,754 nt. (total: 4,754 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

FHY13_RS20010: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FHY13_RS20015: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.66	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.66	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 4754:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FHY13_RS20010: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (6..416): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LAAHFDFSVWEGNQVFGGEVNMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

NZ_JACICH010000015.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 2,516 nt. (total: 2,516 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

FHY13_RS20020: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.61	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002518.3	0.57	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001844.4	0.56	NRPS	holrhizin A, holrhizin B, holrhizin C, holrhizin D	Paraburkholderia rhizoxinica HKI 454
BGC0001517.3	0.55	NRPS	asperphenamate	Aspergillus terreus NIH2624
BGC0000393.5	0.54	NRPS, PKS	myxoprincomide-c506	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.61	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002518.3	0.57	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001844.4	0.56	NRPS	holrhizin A, holrhizin B, holrhizin C, holrhizin D	Paraburkholderia rhizoxinica HKI 454
BGC0001517.3	0.55	NRPS	asperphenamate	Aspergillus terreus NIH2624
BGC0000393.5	0.54	NRPS, PKS	myxoprincomide-c506	Myxococcus xanthus DK 1622

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed domain annotation

Selected features only

Show module domains