LOCUS       NZ_JACICH010000014      4754 bp    DNA     linear   CON 07-MAY-2024
DEFINITION  Xanthomonas euroxanthea strain 2974 Ga0372488_14, whole genome
            shotgun sequence.
ACCESSION   NZ_JACICH010000014
VERSION     NZ_JACICH010000014.1
KEYWORDS    WGS; RefSeq.
SOURCE      Xanthomonas euroxanthea
  ORGANISM  Xanthomonas euroxanthea
            Bacteria; Pseudomonadota; Gammaproteobacteria; Lysobacterales;
            Lysobacteraceae; Xanthomonas.
REFERENCE   1  (bases 1 to 4754)
  AUTHORS   Potnis,N.
  TITLE     Studying the diversity of plant-associated saprophytic bacteria and
            their role in host health and plant-pathogen interactions
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4754)
  AUTHORS   Potnis,N., Huntemann,M., Clum,A., Wang,J., Palaniappan,K.,
            Ritter,S., Chen,I.-M., Stamatis,D., Reddy,T., O'Malley,R., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2020) Prokaryote Super Program, DOE Joint Genome
            Institute, 1 Cyclotron Road, Mail Stop: 91R0183, Berkeley, CA 94720,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 312.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014195725.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 06:44:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,037
            CDSs (total)                      :: 3,960
            Genes (coding)                    :: 3,887
            CDSs (with protein)               :: 3,887
            Genes (RNA)                       :: 77
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 22
            Pseudo Genes (total)              :: 73
            CDSs (without protein)            :: 73
            Pseudo Genes (ambiguous residues) :: 0 of 73
            Pseudo Genes (frameshifted)       :: 27 of 73
            Pseudo Genes (incomplete)         :: 55 of 73
            Pseudo Genes (internal stop)      :: 9 of 73
            Pseudo Genes (multiple problems)  :: 16 of 73
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:54:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 4754
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JACICH010000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..4754
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     gene            complement(<1..3144)
                     /locus_tag="FHY13_RS20010"
                     /old_locus_tag="FHY13_004094"
     CDS             complement(<1..3144)
                     /NRPS_PKS="Domain: AMP-binding (6-416). E-value: 2.5e-103.
                     Score: 337.8. Matches aSDomain:
                     nrpspksdomains_FHY13_RS20010_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (525-593). E-value: 7.4e-18. Score:
                     56.5. Matches aSDomain: nrpspksdomains_FHY13_RS20010_PCP.1"
                     /NRPS_PKS="Domain: Condensation_DCL (620-922). E-value:
                     1.3e-57. Score: 187.2. Matches aSDomain:
                     nrpspksdomains_FHY13_RS20010_Condensation_DCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.4"
                     /locus_tag="FHY13_RS20010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHY13_004094"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_184364053.1"
                     /sec_met_domain="AMP-binding (E-value: 5.3e-114, bitscore:
                     368.0, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.1e-12, bitscore:
                     34.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.4e-46, bitscore:
                     146.0, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLERLFEEQVRLRPEAIAIVDGSERISYAQLDTQSTAIAAALQA
                     RGVQPDEAVGLRMQRSATLIVAMVGLMKAGAGYVALDPIYPEDRLQRMQADSHVRFVIV
                     DAGSAVAQAPASATVLDVATLCAEAVVARGDAGHARLGDQGLAYVLYTSGSTGMPKGTP
                     VSHANVASLLAAANAWFEFGPDDIWSQFHSYAFDFSVWEIWGALAFGGRLVMVPDTVTR
                     APQEFLHLLRKSGVTILNQTPSAFAELHRCMVTEAAAPLPALSVVVFGGEAVDLQDLDR
                     WFARFGDQQPLLVNMYGITETTVHVTYRPLTRDDTGTGNARGTPIGVPLAHLKTYVLDE
                     MLNPVPAGTVGEIHVAGGGVARGYLRRPALTAERFIPDPFTVSPGGRLYRSGDLGYIDV
                     RGELRTLGRGDNQVKVRGYRIEIGEIEATLARHPLLTEAVVVPSQEESGTQLLAFVRPC
                     GDALPQLEALREYLAATLPTYMVPARYAAVPAFPLDVNGKRDRRALLEVEAMPLPRRSC
                     TVAPQNAMERSLSSVWAQVLEIDDFGIDDNYYALGGDSIRSIQIKSKAQEAGIVFSLAD
                     LLRTQTVRQLARIARRQAANESATPRAPFALIAPALADTLRGRYQDAYPVSGTQMGMLY
                     HSSLGADDAVYHNIEVHTLRLPFDGQCLAAVWETLGLQHEILRTGFDLSRPQQPLQVVR
                     PHGWVPLEVLDSRQLDADQVASTLQSWVEQEHVRGFGDWLDEPLFRVCVQRLDDAVFNL
                     IYSCHHAVLDGWSAARLTREFIDLYRQALAGKVGKMVAQTCSYADFIELEQQARADGSP
                     DRLFWSQALVDARPALFERMSPLESRSGAEAVTRVDVPMDAAASAQLKALARELEVPLK
                     SVLLTLHLKTLAVLTGQPEVVSGFVTNGRPERVGGDAVLGLFLNSVPLRLSTAGRSWVQ
                     LIRSAFAQEQALWPYRRLPLSEIMRLHDGRKLFDTLFNFTHFHVYGDEYGDDTSAIVDR
                     GGGFEHSSYPLILQAMQLPGLETLRLVLEADRAVFSPAQIERMVAIYTDALGRMLADPT
                     "
     source          1..4754
                     /country="USA"
                     /db_xref="taxon:2259622"
                     /isolation_source="Rain"
                     /mol_type="genomic DNA"
                     /organism="Xanthomonas euroxanthea"
                     /strain="2974"
                     /submitter_seqid="Ga0372488_14"
     cand_cluster    1..4754
                     /SMILES="NC(C(O)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..4754
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:3144](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..3144)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     aSDomain        complement(379..1284)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHY13_RS20010_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.30E-57"
                     /label="FHY13_RS20010_Condensation_DCL.1"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="922"
                     /protein_start="620"
                     /score="187.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHAVLDG"
                     /tool="antismash"
                     /translation="QDAYPVSGTQMGMLYHSSLGADDAVYHNIEVHTLRLPFDGQCLAA
                     VWETLGLQHEILRTGFDLSRPQQPLQVVRPHGWVPLEVLDSRQLDADQVASTLQSWVEQ
                     EHVRGFGDWLDEPLFRVCVQRLDDAVFNLIYSCHHAVLDGWSAARLTREFIDLYRQALA
                     GKVGKMVAQTCSYADFIELEQQARADGSPDRLFWSQALVDARPALFERMSPLESRSGAE
                     AVTRVDVPMDAAASAQLKALARELEVPLKSVLLTLHLKTLAVLTGQPEVVSGFVTNGRP
                     ERVGGDAVLGLFLNSVPLRLS"
     CDS_motif       complement(385..474)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20010_0007"
                     /evalue="1.60E-04"
                     /label="C5_LCL_267-296"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="920"
                     /protein_start="890"
                     /score="14.2"
                     /tool="antismash"
                     /translation="VVSGFVTNGRPERVGGDAVLGLFLNSVPLR"
     CDS_motif       complement(811..876)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20010_0006"
                     /evalue="5.90E-09"
                     /label="C3_DCL_135-156"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="778"
                     /protein_start="756"
                     /score="28.4"
                     /tool="antismash"
                     /translation="CHHAVLDGWSAARLTREFIDLY"
     CDS_motif       complement(1102..1188)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20010_0005"
                     /evalue="3.90E-04"
                     /label="C2_DCL_024-062"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="681"
                     /protein_start="652"
                     /score="12.7"
                     /tool="antismash"
                     /translation="TLRLPFDGQCLAAVWETLGLQHEILRTGF"
     aSDomain        complement(1366..1569)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHY13_RS20010_PCP.1"
                     /evalue="7.40E-18"
                     /label="FHY13_RS20010_PCP.1"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="593"
                     /protein_start="525"
                     /score="56.5"
                     /tool="antismash"
                     /translation="ERSLSSVWAQVLEIDDFGIDDNYYALGGDSIRSIQIKSKAQEAGI
                     VFSLADLLRTQTVRQLARIARRQ"
     aSModule        complement(1366..4556)
                     /complete
                     /domains="nrpspksdomains_FHY13_RS20015_Condensation_DCL.1"
                     /domains="nrpspksdomains_FHY13_RS20010_AMP-binding.1"
                     /domains="nrpspksdomains_FHY13_RS20010_PCP.1"
                     /locus_tags="FHY13_RS20010"
                     /locus_tags="FHY13_RS20015"
                     /monomer_pairings="Thr -> Thr"
                     /monomer_pairings="Thr -> Thr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(1867..1929)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20010_0004"
                     /evalue="2.70E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="426"
                     /protein_start="405"
                     /score="32.3"
                     /tool="antismash"
                     /translation="LGRGDNQVKVRGYRIEIGEIE"
     aSDomain        complement(1897..3126)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHY13_RS20010_AMP-binding.1"
                     /evalue="2.50E-103"
                     /label="FHY13_RS20010_AMP-binding.1"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="416"
                     /protein_start="6"
                     /score="337.8"
                     /specificity="substrate consensus: Thr"
                     /tool="antismash"
                     /translation="FEEQVRLRPEAIAIVDGSERISYAQLDTQSTAIAAALQARGVQPD
                     EAVGLRMQRSATLIVAMVGLMKAGAGYVALDPIYPEDRLQRMQADSHVRFVIVDAGSAV
                     AQAPASATVLDVATLCAEAVVARGDAGHARLGDQGLAYVLYTSGSTGMPKGTPVSHANV
                     ASLLAAANAWFEFGPDDIWSQFHSYAFDFSVWEIWGALAFGGRLVMVPDTVTRAPQEFL
                     HLLRKSGVTILNQTPSAFAELHRCMVTEAAAPLPALSVVVFGGEAVDLQDLDRWFARFG
                     DQQPLLVNMYGITETTVHVTYRPLTRDDTGTGNARGTPIGVPLAHLKTYVLDEMLNPVP
                     AGTVGEIHVAGGGVARGYLRRPALTAERFIPDPFTVSPGGRLYRSGDLGYIDVRGELRT
                     LGRGDNQVKVR"
     CDS_motif       complement(2020..2109)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20010_0003"
                     /evalue="7.90E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="375"
                     /protein_start="345"
                     /score="50.1"
                     /tool="antismash"
                     /translation="PAGTVGEIHVAGGGVARGYLRRPALTAERF"
     CDS_motif       complement(2149..2184)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20010_0002"
                     /evalue="7.70E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="332"
                     /protein_start="320"
                     /score="-2.6"
                     /tool="antismash"
                     /translation="ARGTPIGVPLAH"
     CDS_motif       complement(2647..2706)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20010_0001"
                     /evalue="6.90E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="FHY13_RS20010"
                     /protein_end="166"
                     /protein_start="146"
                     /score="27.8"
                     /tool="antismash"
                     /translation="AYVLYTSGSTGMPKGTPVSH"
     gene            complement(3141..>4754)
                     /locus_tag="FHY13_RS20015"
                     /old_locus_tag="FHY13_004095"
     CDS             complement(3141..>4754)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_DCL (65-365). E-value:
                     4.5e-61. Score: 198.5. Matches aSDomain:
                     nrpspksdomains_FHY13_RS20015_Condensation_DCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.4"
                     /locus_tag="FHY13_RS20015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FHY13_004095"
                     /product="condensation domain-containing protein"
                     /protein_id="WP_221197582.1"
                     /sec_met_domain="Condensation (E-value: 6.4e-54, bitscore:
                     170.1, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="IQIKAQAQQQGLEFALEALFERQTVARLAEVTTRTTGAAVVPLPR
                     VAPFALVDARVCERLPADVDDAYPASRMQMALLYHSDTSQDAIVYQDVVCYEVALSWNA
                     ATLQQVVDDLAVQHPVLRTSFSMAYGTEPLQLVWKNARIPLKVLPAAKDTVQANSELDA
                     LIARETLTAFDWGTAPLCRIHVMPLPAASRFHLCVTFHHAILDGWSETLLVKQMLTCYR
                     HALTGQPPLANGKTLPYREFIALEKAALGSEDSRTYWQAQLAQYTDASLEPADGGLGDH
                     AATSRIEREIEVADAVEERLNALAVAVGVPLKSVLLAAHLKVLAVALGQSDVITGVTVN
                     GRPEQEGGERTLGLFINTVPMRARLGGGRWHDLVRNVFERERETLPHRRFPLAEIVKSC
                     GGMPFDTAFNFTRFHVGEQMYSGEEAPIRDRRGFAATHFACVAEFMVRPGENRLRCVLI
                     FDGAKVPLPRQEIVAALYAQVLVAIAADPDAYHAGWGGVVAAQAELPLDPAILPEGFRK
                     RRRSAAPQPPVIDNSTELFQ"
     CDS_motif       complement(3330..3383)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20015_0005"
                     /evalue="1.80E+01"
                     /label="C3_dual_135-156"
                     /locus_tag="FHY13_RS20015"
                     /protein_end="474"
                     /protein_start="456"
                     /score="-1.2"
                     /tool="antismash"
                     /translation="LIFDGAKVPLPRQEIVAA"
     aSDomain        complement(3657..4556)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FHY13_RS20015_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="4.50E-61"
                     /label="FHY13_RS20015_Condensation_DCL.1"
                     /locus_tag="FHY13_RS20015"
                     /protein_end="365"
                     /protein_start="65"
                     /score="198.5"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHAILDG"
                     /tool="antismash"
                     /translation="DAYPASRMQMALLYHSDTSQDAIVYQDVVCYEVALSWNAATLQQV
                     VDDLAVQHPVLRTSFSMAYGTEPLQLVWKNARIPLKVLPAAKDTVQANSELDALIARET
                     LTAFDWGTAPLCRIHVMPLPAASRFHLCVTFHHAILDGWSETLLVKQMLTCYRHALTGQ
                     PPLANGKTLPYREFIALEKAALGSEDSRTYWQAQLAQYTDASLEPADGGLGDHAATSRI
                     EREIEVADAVEERLNALAVAVGVPLKSVLLAAHLKVLAVALGQSDVITGVTVNGRPEQE
                     GGERTLGLFINTVPMRARL"
     CDS_motif       complement(3666..3758)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20015_0004"
                     /evalue="8.50E-11"
                     /label="C5_DCL_263-294"
                     /locus_tag="FHY13_RS20015"
                     /protein_end="362"
                     /protein_start="331"
                     /score="34.3"
                     /tool="antismash"
                     /translation="DVITGVTVNGRPEQEGGERTLGLFINTVPMR"
     CDS_motif       complement(3879..3914)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20015_0003"
                     /evalue="1.10E+01"
                     /label="C3_dual_135-156"
                     /locus_tag="FHY13_RS20015"
                     /protein_end="291"
                     /protein_start="279"
                     /score="-0.5"
                     /tool="antismash"
                     /translation="DHAATSRIEREI"
     CDS_motif       complement(4089..4154)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20015_0002"
                     /evalue="2.80E-07"
                     /label="C3_DCL_135-156"
                     /locus_tag="FHY13_RS20015"
                     /protein_end="221"
                     /protein_start="199"
                     /score="23.1"
                     /tool="antismash"
                     /translation="FHHAILDGWSETLLVKQMLTCY"
     CDS_motif       complement(4377..4445)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FHY13_RS20015_0001"
                     /evalue="1.40E-05"
                     /label="C2_LCL_024-062"
                     /locus_tag="FHY13_RS20015"
                     /protein_end="125"
                     /protein_start="102"
                     /score="17.5"
                     /tool="antismash"
                     /translation="NAATLQQVVDDLAVQHPVLRTSF"
ORIGIN
        1 ggtggggtcg gccagcatgc ggcccagcgc atcggtatag atggccacca tgcgctcgat
       61 ctgcgccggc gaaaacaccg cgcgatcggc ttccagaaca agccgcaagg tttccaagcc
      121 gggcagctgc atcgcctgca ggatcaacgg ataactggaa tgctcgaagc caccaccacg
      181 atccacgatc gcagaggtat cgtcaccgta ttcgtcgccg tagacatgga aatgggtgaa
      241 gttgaacagc gtatcgaaca gcttccggcc gtcatgcagg cgcatgatct ccgatagtgg
      301 caggcgtcgg tatggccaca atgcctgctc ctgggcaaac gcagatcgga tcagctgcac
      361 ccagctccga ccagcagttg acagccgcaa tggcacgctg ttgagaaaca ggcccaagac
      421 ggcatcgcca ccgacccgct cgggacgacc attggtgaca aacccgctga ccacctcagg
      481 ctggccagtg agaacggcca gggttttgag atgcaaggtc agcaacacgc tcttcagcgg
      541 tacttccagt tcgcgcgcga gagccttcaa ctgtgccgat gccgcggcgt ccattggcac
      601 gtcgacgcgg gttaccgcct cggcacctga acgcgactcc agcggcgaca tgcgctcgaa
      661 cagcgccggc cgtgcatcga ccagggcctg cgaccaaaac aagcggtccg gcgagccgtc
      721 tgcgcgcgcc tgctgttcca gttcaataaa atcggcgtag ctgcacgtct gcgctaccat
      781 cttaccaacc ttgccggcga gtgcctgtcg gtaaagatcg atgaactcgc gcgtcagtcg
      841 cgccgcgctc cagccatcga ggacggcgtg gtggcaactg tagatgagat tgaacaccgc
      901 atcatccaac cgctgcacgc agacacggaa cagtggctcg tccagccagt cgccaaaacc
      961 gcgcacgtgt tcctgctcta cccaggactg cagggtactt gcgacctgat cggcgtcgag
     1021 ctgacgcgaa tcgaggactt ccagcggtac ccacccgtga ggacggacca cctgtaacgg
     1081 ctgctgcggc cgcgatagat cgaagccggt ccgcaggatc tcatgctgca ggcccaacgt
     1141 ttcccacacc gccgccagac attggccatc aaatggcaaa cgcaacgtat gtacttcaat
     1201 gttgtggtac accgcgtcgt cggcacccag gctgctgtga tacagcatgc ccatctgcgt
     1261 tccgctgacc gggtaggcgt cctgatagcg accgcgcagg gtgtcagcca gcgcaggggc
     1321 gatcagagcg aacggcgcac gtggcgttgc gctctcgttc gccgcctgcc gccgggcgat
     1381 cctggcaagc tgacgcacgg tttgcgtgcg tagcagatcg gccaggctga acacgatgcc
     1441 ggcttcctgc gccttggact tgatctgtat gctgcggatc gaatctccgc caagtgcgta
     1501 gtagttgtca tcgatgccga agtcatcgat ttccaacacc tgggcccata ccgacgacaa
     1561 actgcgctcc atagcgttct gcggcgccac ggtgcaggaa cggcgtggca gtggcatcgc
     1621 ctccacctcc agcagcgccc gtcggtcgcg cttgccattg acgtcgagcg gaaatgccgg
     1681 cacggcggcg tagcgcgcag gcaccatgta ggtcggtagc gtcgcggcga gatattcgcg
     1741 cagggcctcc agctgcggta gggcatcacc acagggacgt acgaacgcca acagctgggt
     1801 gccgctctcc tcctgggacg gcaccaccac cgcttcggtg agcaagggat gtcgcgcgag
     1861 cgttgcttcg atctcaccga tttcgatgcg atagccgcgc actttgacct gattatcgcc
     1921 tcgacccaag gtgcgcagtt caccgcgcac atcgatatag ccgaggtcgc cgctgcgata
     1981 aaggcgccca ccgggcgaga cggtgaacgg atctgggatg aagcgctcgg ctgtcagggc
     2041 cggccgccgc agataaccgc gtgcaacgcc gccaccagcg acgtggatct cgcccacggt
     2101 accggccggc acggggttga gcatctcatc gagtacgtat gtcttcaggt gtgccaacgg
     2161 cacgccgatc ggtgtgccgc gcgcattacc ggtgccggta tcgtcccggg tcaagggccg
     2221 gtaggtcacg tgaaccgtcg tttcggtaat accgtacatg ttgaccagca atggctgctg
     2281 gtcaccgaag cgcgcaaacc agcggtcgag atcctgcagg tccactgcct cgcccccgaa
     2341 tacgaccacg ctcaacgcgg gcagcggcgc tgccgcttcg gtcaccatgc agcggtgcag
     2401 ctcggcgaac gccgacggag tttgattgag tatcgtgacc ccgctcttac gcaacagatg
     2461 caggaattcc tgcggggcac gcgtcaccgt atcgggcacc atcaccagcc tgccgccgaa
     2521 cgccagcgcc ccccagattt cccagacaga gaaatcgaac gcataggaat ggaactggct
     2581 ccagatatcg tccgggccga actcgaacca cgcgttggcg gccgccagca acgatgccac
     2641 gttggcgtgc gaaaccgggg tgcccttcgg catgccggtg gaaccggagg tgtacagcac
     2701 atacgccaag ccctggtctc ccagccgcgc atggccggca tcgccccgag caaccacggc
     2761 ttccgcacac agcgtcgcaa cgtccagtac ggtggccgat gcaggcgctt gcgcaaccgc
     2821 gcttccggca tcgacgatca caaaacgcac atggctgtcc gcctgcatgc gttgcagacg
     2881 gtcctcggga tagatcggat ccagggccac gtagccggca ccggccttca tcagccccac
     2941 catcgctaca atcagcgttg ccgagcgctg catgcgcagg cccaccgcct cgtccggctg
     3001 gaccccgcgc gcctgcagcg ccgctgcgat cgccgtggac tgcgtgtcca gctgcgcgta
     3061 gctgatacgt tcgctgccat ccacgatcgc gatggcctcg ggacgcaacc gcacctgctc
     3121 ttcaaacagt cgttcgagtc tcactggaat agttccgtgc tgttgtctat gaccggcggt
     3181 tgcggcgcgg cgctgcggcg acgtttcctg aaaccctccg gcaggatcgc cggatccagc
     3241 gggagctctg cctgtgcggc gaccactccc ccccatccgg cgtggtacgc atcgggatcg
     3301 gcggcaatgg cgacaagcac ctgtgcgtac agcgcagcaa cgatttcctg gcgcggcaac
     3361 ggaaccttcg caccatcaaa gatcaggacg cagcgcagtc ggttctcgcc gggccgtacc
     3421 atgaactcgg ccacgcaggc gaaatgagtg gcggcgaagc cgcgcctgtc gcggatcggg
     3481 gcttcctcgc cgctgtacat ctgctcgccc acgtggaatc gggtgaagtt gaaggccgtg
     3541 tcgaacggca tgccgccgca gctcttgacg atctcggcca gggggaatcg acggtgtggg
     3601 agcgtttcgc gctcgcgctc gaacacattc cggaccagat cgtgccagcg cccgccaccg
     3661 aggcgtgcgc gcatcggcac ggtgttgatg aacaggccca atgtgcgttc tcccccctcc
     3721 tgctccggcc gcccgttaac ggtgaccccg gtgatcacat cgctctgccc cagagccacc
     3781 gccagcactt tcaagtgcgc ggccagcaac accgacttga gcggcacccc cacagccact
     3841 gccaaggcat tgagcctttc ctctacggca tcggctacct cgatttcacg ttcgatacgg
     3901 gatgtggcag cgtggtcgcc cagaccgccg tccgcaggct ccagcgatgc atcggtgtat
     3961 tgggccagct gcgcctgcca gtaggtccgg ctgtcttcgc tgccgagcgc tgccttttcc
     4021 agcgcgatga actcgcggta aggcaacgtc ttgccattgg caagcggggg ctgcccagtc
     4081 aatgcgtggc gatagcaggt aagcatctgc ttgactagca gtgtttcgct ccagccatcg
     4141 aggatcgcat ggtggaaggt cacgcaaagg tggaagcgcg aggcggccgg caacggcatg
     4201 acatggatgc ggcataacgg ggccgtgccc caatcgaatg cggtcagcgt ttcgcgagca
     4261 atcaatgcat ccagttcgct gttcgcctgc acggtgtcct tcgcggctgg cagcaccttc
     4321 agcggaattc gcgcgttctt ccacaccaac tgcagaggct cggtaccgta tgccatcgag
     4381 aacgatgttc gcagcaccgg gtgctgcacg gccagatcgt cgaccacctg ctgcagcgta
     4441 gcggcattcc aggacagggc gacctcgtag cagaccacgt cctggtagac gatggcgtcc
     4501 tggctggtgt cgctgtggta cagcagcgcc atctgcatac gcgacgcagg ataagcatca
     4561 tccacgtcgg caggtagtcg ctcgcatacg cgagcatcga ctagggcaaa tggcgcgacc
     4621 ctgggcagcg ggacgaccgc cgcacctgtg gtacgtgtgg tcacctcggc cagcctggcc
     4681 acggtctggc gttcgaacaa cgcctccagc gcaaactcca gcccttgttg ctgcgcctgc
     4741 gccttgatct ggat
//
