LOCUS       NZ_JABBXA010000019     24977 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H13382 NODE_19, whole genome shotgun sequence.
ACCESSION   NZ_JABBXA010000019
VERSION     NZ_JABBXA010000019.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H13382
  ORGANISM  Microbispora sp. H13382
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 185865)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 185865)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Antibiotics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014161445.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 07:22:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,906
            Genes (coding)                    :: 7,786
            CDSs (with protein)               :: 7,786
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 21 of 121
            Pseudo Genes (incomplete)         :: 104 of 121
            Pseudo Genes (internal stop)      :: 8 of 121
            Pseudo Genes (multiple problems)  :: 11 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:45:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 153878
            Orig. end                         :: 178855
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBXA010000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24977
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24977
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24977
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:14977](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14977)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(644..1900)
                     /locus_tag="HHX41_RS30605"
     CDS             complement(644..1900)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.5"
                     /locus_tag="HHX41_RS30605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase"
                     /protein_id="WP_169988766.1"
                     /transl_table=11
                     /translation="MDSDSARGIDRRRLVRWGGLAAAGVVAAGGPLVSAGAGHAASSPT
                     DSSRRDRVPRDTLPGGAYDRYIARLAAEGKFSGVVLLSHRGRTVLSRSYGMADREKGIP
                     NHEGTAFSLSSAGKPFHAVAILQLAQRGRLRLSDTVGKYLTGFDPEVAERVTVHHLLSG
                     TSGLDSPDEDVRRVFQSRAEVHDHYVRRARQARLVGVPGTPSTTHQEAEVTIPALIVEA
                     VTGSTYWDYVQENIFKRCGMTGAGFYTRPQWLTDGRIAHPYMTLADGSQVDAVRNLDKG
                     SPAPYVLGKNPGRCFIDAPGDGGFATAPDLVRFAQALGDGTVLDRPWSDVLTAAKIPHG
                     PTSFGAYGISIDIVNGQWMFQRAGGNPGVGANWSIYPDTGWVGVILGNSDSEGVSLQDM
                     IGRETQAITGASPDGGSGG"
     misc_feature    complement(1937..1952)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            2073..2675
                     /locus_tag="HHX41_RS30610"
     CDS             2073..2675
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018028.5"
                     /locus_tag="HHX41_RS30610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RDD family protein"
                     /protein_id="WP_182908721.1"
                     /transl_table=11
                     /translation="MTTTPQAATRTTAARRHRFAAFLVDNVILLAANTATGLVLGIAGQ
                     PEADEADYLTTLLNPYAEADWPLQIAIIAAGAAYFWVQHALWGQTLGKRLYRLKVVPAG
                     TGATLTHRQVGIRTLVHPLLSSAAPYLGPVLYLVDALWIFGDPGRRCLHDVIAGTVVVD
                     VPAPGTKASRRSGFLIGLVVLVSVFAAFVLVTTLLAA"
     gene            complement(2683..3570)
                     /locus_tag="HHX41_RS30615"
     CDS             complement(2683..3570)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS30615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="WP_182908722.1"
                     /transl_table=11
                     /translation="MTRHGFTLTAQGPFDFGATLRFVEDWPATSGLPSDGRALCFAYCA
                     ESDWLPIGVTVTAAPDGVAVATTRAAGPGIRGEVARILSLDVDGSGFAEAGDADPVLGD
                     LQRKSPGLRPLCFWSPWEAACWAVIVQRSSMLVAARLKQRIAERYGAQVTVDREPYAAF
                     PPPMTLLEAGGLGLPAQKEEWLRGLARAALDGVLTAEHLRALDPQEALAELRALPGVGP
                     FSAGLILIRGAGAPDAFPGDEPRLFAILREAYGLPEDAPPAAYRKVAEAWRPYRSWASF
                     LFRASGYGVPADER"
     gene            3904..4194
                     /locus_tag="HHX41_RS30620"
     CDS             3904..4194
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (9-77). E-value: 7.9e-10.
                     Score: 30.9. Matches aSDomain:
                     nrpspksdomains_HHX41_RS30620_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.5"
                     /locus_tag="HHX41_RS30620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl carrier protein"
                     /protein_id="WP_182908723.1"
                     /sec_met_domain="PP-binding (E-value: 1e-09, bitscore:
                     32.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEEYTRRLAQLISEVSDGEITVEEVLAAGHSLSALGLTSFARI
                     RLIDAIEHAFGVEMDLSDELASFEDVGTLSALVARAPAVGGTAVGGTARAW"
     aSDomain        3931..4134
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX41_RS30620_PP-binding.1"
                     /evalue="7.90E-10"
                     /label="HHX41_RS30620_PP-binding.1"
                     /locus_tag="HHX41_RS30620"
                     /protein_end="77"
                     /protein_start="9"
                     /score="30.9"
                     /tool="antismash"
                     /translation="LAQLISEVSDGEITVEEVLAAGHSLSALGLTSFARIRLIDAIEHA
                     FGVEMDLSDELASFEDVGTLSAL"
     gene            4188..5567
                     /locus_tag="HHX41_RS30625"
     CDS             4188..5567
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Condensation_LCL (12-289). E-value:
                     1.3e-28. Score: 91.9. Matches aSDomain:
                     nrpspksdomains_HHX41_RS30625_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="HHX41_RS30625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_182908724.1"
                     /sec_met_domain="Condensation (E-value: 5.9e-24, bitscore:
                     78.0, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTVAFSGARDGEAPLTWGQRLIWRAVHLMGDSQTFLSCPWVLPV
                     YGRRDVGSVLDALRVLLERHESLRTTFALTPEGPVQRVARGGELTVDVVEAGQDRALRV
                     AERVAGELGRTAFVHDRDLPLRCALVVKNDRPMALAIAFSHLAVDFQALNTLSEEWKVL
                     LRGEKPPPAEWQPMDQAAAELEEPYPARSAKSIRYWHSVLADGPLDVFDHPPREADDPR
                     FIEVGMESTALAVAAQRLAERWTISTTSVLLAACATVLATVSGRPRAVMQLVHSNRRDP
                     RTHAMVGTVEQDGLFVLDLPATDFAAACRAAQRGALRAYRNAHYDPFEMQAMREEIGRR
                     RGREPDLDAFFNDRRTVGTWPGLPPVGPDEDVARLTSQTRTYVTNAWPGVRFKAFFTVV
                     SAPDTGQLSLIVDTAYLPREVAEAMLRGVEALLVRALTEDVPMTAVPKVCGIGPYAGSP
                     T"
     aSDomain        4224..5054
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX41_RS30625_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.30E-28"
                     /label="HHX41_RS30625_Condensation_LCL.1"
                     /locus_tag="HHX41_RS30625"
                     /protein_end="289"
                     /protein_start="12"
                     /score="91.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: SHLAVDF"
                     /tool="antismash"
                     /translation="EAPLTWGQRLIWRAVHLMGDSQTFLSCPWVLPVYGRRDVGSVLDA
                     LRVLLERHESLRTTFALTPEGPVQRVARGGELTVDVVEAGQDRALRVAERVAGELGRTA
                     FVHDRDLPLRCALVVKNDRPMALAIAFSHLAVDFQALNTLSEEWKVLLRGEKPPPAEWQ
                     PMDQAAAELEEPYPARSAKSIRYWHSVLADGPLDVFDHPPREADDPRFIEVGMESTALA
                     VAAQRLAERWTISTTSVLLAACATVLATVSGRPRAVMQLVHSNRRDPRTHAMVGT"
     CDS_motif       4353..4406
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX41_RS30625_0001"
                     /evalue="1.00E-06"
                     /label="C2_LCL_024-062"
                     /locus_tag="HHX41_RS30625"
                     /protein_end="73"
                     /protein_start="55"
                     /score="21.1"
                     /tool="antismash"
                     /translation="DALRVLLERHESLRTTFA"
     gene            complement(5564..5887)
                     /locus_tag="HHX41_RS30630"
     CDS             complement(5564..5887)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS30630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_182908725.1"
                     /transl_table=11
                     /translation="MARSWRRFPGWLSTGACLDGEWGDGTRQAILVDPPLGAPFERLRF
                     GHADPDLDARLRRAPEAARRAALLLLARHLAERFALDDPPIAAAIDEVAGGGLLGEELR
                     WDL"
     gene            complement(5965..6597)
                     /locus_tag="HHX41_RS30635"
     CDS             complement(5965..6597)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547810.1"
                     /locus_tag="HHX41_RS30635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysE family translocator"
                     /protein_id="WP_182908726.1"
                     /transl_table=11
                     /translation="MDINGALASFAVIVAFLTLTPGLDTALILRTSLLAGRRPAWAVVL
                     GIQAGTLLWGLLTAAGLSALLTASQVAYEVLRWAGVAYLIWMGARMLWHSRDSRADDVA
                     PPGPADAGWGQAFRRGLLTNLLNPKVGAFYVAVLPQFMPEGVPHAVMGVLLAGVHVCEA
                     LVWSAVLIGFTGMMRGWLRRPVVKRALDRLTGLIVIGFGLRLAVQQS"
     misc_feature    complement(6580..6596)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.08"
                     /tool="antismash"
     misc_feature    6704..6719
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.17"
                     /tool="antismash"
     gene            6712..6909
                     /locus_tag="HHX41_RS30640"
     CDS             6712..6909
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS30640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169988753.1"
                     /transl_table=11
                     /translation="MDEPMPVRLADGRDLKCDTCENELFEQHRWKLQTTGMTFMNLDWA
                     NRDATCFVCSSCRRIHWFHW"
     gene            complement(6964..7491)
                     /locus_tag="HHX41_RS30645"
     CDS             complement(6964..7491)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS30645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_182908727.1"
                     /transl_table=11
                     /translation="MCPRPYASRLIGRAGLVAVPMAVLLTACGTPQPEVRSRPAAPGGP
                     ATATVPAAASPSPAPSVVRAADDPQACRRADCEVEVRPGDRLRLDRKTGLDVITVVSVD
                     RGEVRLRFEAGGGTFRVEGMNTDVSQDCVNGRCRTEGGLTLAMGRPGRIGDIRLRLASV
                     APDHAVLVLAPS"
     gene            complement(7630..8445)
                     /locus_tag="HHX41_RS30650"
     CDS             complement(7630..8445)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013757.5"
                     /locus_tag="HHX41_RS30650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_182908728.1"
                     /transl_table=11
                     /translation="MGLFVASDRRAEAASALGSLERGIEILLCLAAGMRPMNLTQVHRS
                     TGFSKTTTHRLLGTLQRRGLVTRTGGDYTVGGRVADLVAPRGWAVQGRRLPGSRKAVLP
                     HLLQLYEATRQTVNLAVPDGFEVAYVERLYGHNRVKSPSDGLDRAPLYCTAAGKVLLAH
                     DAGLRTAFLAAPALRRVTGRTVTGRTVTGPAALERELAAVRGEGVGYAREEFAEGVCCA
                     AAPVFGPDGGVCMAVAVAAPAGAVGTAALPRLGAAVRRTARQITGALSL"
     misc_feature    complement(8458..8471)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            complement(8673..10004)
                     /locus_tag="HHX41_RS30655"
     CDS             complement(8673..10004)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658244.1"
                     /locus_tag="HHX41_RS30655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_182908729.1"
                     /transl_table=11
                     /translation="MTAPRLTLSTAAARNLATTAKTPPQMREITPRHLLRVLPWTEVQG
                     GVYRVNRRLTCTVGDGRVSFVSTGARVRVVPPELCELPSLHDYGDLDTLGALADRFVQH
                     DLRPGEPVPPGQVVLVAHGKIARVGAGAYGGEALLQVLADGDHLGDLTGPGAAPAKALT
                     SCIVLVLERSALDNLTALSGGLREHLGRPPVARPVNRYGEAEIALAAGHEGEATLPGTF
                     VDYELGPREYELSVAQTILRVHSRVADLYNEPMNQTEQQLRLTIEALRERQEHELVNNR
                     DFGLLHNADLKQRVHTRSGPPTPDDLDELLARRRSSHYFLAHPRAIAAFGRQCTRRGVY
                     PDVTEVNGATVMAWRGVPILPCDKIPITEGGLSSIVVMRTGAEKQGVVGLRRTGLVDEY
                     EPGLSVRFMDIDDKAIISYLVTTYYSAAVLVPDALGVLESVEVN"
     gene            complement(10001..12259)
                     /locus_tag="HHX41_RS30660"
     CDS             complement(10001..12259)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658229.1"
                     /locus_tag="HHX41_RS30660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="terpene synthase family protein"
                     /protein_id="WP_220504563.1"
                     /sec_met_domain="T1TS (E-value: 1.7e-81, bitscore: 268.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSYRLPDFYLPYPPRLNPHVETARAHTRRWAADMGMLDDPDIWT
                     EESLEAMDYGLMCAYTHPDCSAPELDLVTDWYVWVFYFDDHFLETFKRSRDLDGAQDYL
                     DRLDAFMSDDPPEPTNPVERGLADLWPRTVPAMSEAWRRRFVRVTRDLLQESMWELFHI
                     EREAVSNPIEYIEERRKVGGAPWSAALVEHAAGAELPARLAGSRPVRVLTESFADAVHL
                     RNDLFSYEREVLKEGELSNCVLVCERFFGCDTARAVEITNDLLTSRLHQFEHTALTELA
                     ALFADEGVLPPEQAPVLSYVKGLQDWQAGGHAWHTASSRYTKSGSLPGPLGVNVSRAHL
                     TGAGGLRNHTHTPYQQVSVRRPKPYMPFEVRDNPHLDAARTADVEWCAAMGFFDGVPGI
                     PATAVWTEPQLVGFDLALCASGINPDATAGELILATNWLAWGTYGDDYYPRVYGPARDL
                     VGAKLGNRRLKEFMPLDLVPRLTPMTGLERGLADLWPRTAGPLPEGSRRAFRAAVEEMI
                     DSWVWELANQAQHRVPEPIDYIEMRRRTFGSQMTMSLARLAPGRVIPMEIHRTREFLGM
                     TDAAQDYACLLNDLFSYQKEIQFEGELHNAVVVLGTFLGCAPDEAVTVVDALMTSRMRQ
                     FEHITTVDLPALLDRIEAREDVRRSVEGYVSDLRNWMAAILRWHERSRRYFEEELRRGP
                     AARWSQGPTGLGTATARILSLAPPAHRSPALTASSVTAPTLASSDLAAPADPLPVGAP"
     gene            complement(12259..13632)
                     /locus_tag="HHX41_RS30665"
     CDS             complement(12259..13632)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619264.1"
                     /locus_tag="HHX41_RS30665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_182908755.1"
                     /transl_table=11
                     /translation="MPNDNRLSLSTRAARNLATTTKTPPQMQEITSRHLLRVLPWIEAV
                     GGAYRVNRRLTYQMADGRVTFVSTGADVRVISAELCELPALRGFGDPDVLAAMADLFTQ
                     REYEAGQVIAEAGTPMDEVVLLAHGKVDKHGQGAYGNETLLGVLADGEYVGEQMLVNAD
                     ARWEWTVKAVTPCTVLTLGRDEFERLLTLSDSLREHVQAYHGDPDRPVNRYGEAEIALA
                     AGHEGEATLPGTFVDYELGPREYELSVAQTILRVHSRVADLYNEPMNQTEQQLRLTIEA
                     LRERQEHELVNNRDFGLLHNADLKQRVHTRSGPPTPDDLDELLTMVWKNPSVMFAHPKA
                     IAAFARQCNSRGIYPQTVEFSGQKAPAWRGVPMLPCNKIPVNDKGISSIMVMRLGEKDQ
                     GVVGLRRTGLVDEYEPGLSVRFMGIDDKAIISYLVTTYYSAAVLVPDALAILESVEVL"
     gene            complement(13901..14977)
                     /locus_tag="HHX41_RS30670"
     CDS             complement(13901..14977)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.5"
                     /locus_tag="HHX41_RS30670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_259401424.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.5e-51, bitscore:
                     166.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGIVDTSITGMTGRVRRRVDELLADFLDARRPPVGDPDVAEGY
                     RLLREFVVEGGKRVRPLLCYWGWRGAGGEEPHEDRAVVTGAALELYHAGLLIHDDVMDG
                     SELRRGRPTIHRGLARAPRWPGAETFGRSAAILLGVLAQAWADELLADATTGDVRGRAA
                     RELFNRMRTEVVTGQYLDILAHTRADADVEQALMVIRYKTARYTVERPLQIGGALAGAP
                     PALLEAYSRFGLPLGEAFQLRDDVLGVFGDPAVTGKPVLDDLREGKRTVLMAHAYARAR
                     GPERDLLRTWHGDPGLDERRAAELRRVIVDTGALDEVEELIALRAGQAIEALRDEAIAP
                     EAARALAVLTERLTRRVR"
     gene            complement(15284..15709)
                     /locus_tag="HHX41_RS30675"
     CDS             complement(15284..15709)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS30675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_182908730.1"
                     /transl_table=11
                     /translation="MPKFAISPYRLWTSSLVDRGRSSWQAAIESSYVPADPAQLTEYSL
                     AFEPENVRIFTIDRPADVGSLVSRYATCEDGRSLVDWRAVAREYDGVHLTFRGLLTAQG
                     VPIKTGAASFVLHGWDAESVARFDCRHFDDVATRTCR"
     misc_feature    complement(15512..15514)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16259..16390)
                     /locus_tag="HHX41_RS41155"
     CDS             complement(16259..16390)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS41155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_259401425.1"
                     /transl_table=11
                     /translation="MSTNSANTCTDGTYMGHGSGYYDSASGAKFGGSMDSTERDITC"
     misc_feature    complement(16396..16409)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.03"
                     /tool="antismash"
     gene            complement(16530..17510)
                     /locus_tag="HHX41_RS30680"
     CDS             complement(16530..17510)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1208: pirin
                     domain-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017623880.1"
                     /locus_tag="HHX41_RS30680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pirin family protein"
                     /protein_id="WP_220504564.1"
                     /transl_table=11
                     /translation="MSPGESALYGCTVLHGGTGATEAEPESVLMPGHDVPLGRYTTVRR
                     LLPQRPRRMVGAWCFVDHFGPDDVSGRPGMQVPPHPHTGLQTVTWLAEGEILHRDSLGN
                     VQPIVPGQLNLMTAAHGIAHSEQSPQEHPPGMHGLQLWVALPEDARHGEARFEHHAALP
                     VLREGNVTVTVVVGEAGPLRSPALVHTPLLGAEVLFAGPGEHRLPVDPAFETAVLAMSG
                     TADVAGVALAPGSLLYLGRGRTEVPIEAAGPARLFVLGGTPFEEPLVMWWNFVGRSHEE
                     IARARDDWARGDRFGVVPGGERRLPAPEMPTVRLKARDRHGRILS"
     gene            complement(17507..17842)
                     /locus_tag="HHX41_RS30685"
     CDS             complement(17507..17842)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014911861.1"
                     /locus_tag="HHX41_RS30685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_169988743.1"
                     /transl_table=11
                     /translation="MAQTEPQVADNPEASRFEITVDGALAGFADYRLKGPAISLTHTEI
                     DPAFEGRGLGSTLVRAALDAARDAGLSVLPFCPFVQRYIARHPEYLDLVPADRRARFSL
                     DGGEGSK"
     gene            complement(17863..18633)
                     /locus_tag="HHX41_RS30690"
     CDS             complement(17863..18633)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1208: pirin
                     domain-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF014708.5"
                     /locus_tag="HHX41_RS30690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pirin-like bicupin family protein"
                     /protein_id="WP_182908731.1"
                     /transl_table=11
                     /translation="MTTTRLTPRVDIRRAADRFATRISWLDSKHSFSFGGHYDAGNTHH
                     GLLLVNNDDVVHPGTGFETHPHRDMEIVTWVLQGSLVHQDSEGHNGVIYPGLAQRMSAG
                     TGILHSEKNDSWRLTGGDTHDKPVHFVQMWVVPDEPGIAPGYEQLEIENELLAGGLVPV
                     ASGMDKHDGEAAIRIKNRYAALYAARLQPGQTVELPEAPFLHLFVPRGSVTLEGAGTLE
                     TGDAVRFTATGGQKVTATEPAEILVWEMHATIAA"
     gene            18730..19254
                     /locus_tag="HHX41_RS30695"
     CDS             18730..19254
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888477.1"
                     /locus_tag="HHX41_RS30695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_182908732.1"
                     /transl_table=11
                     /translation="MDSPRWLDADEQRAWRAYLRMQGRLTARLNRQLQADSGLSLADYE
                     VLVHLTDREEGRLRPFELQRDLQWEQSRLSHHLTRMERRGLVSREECADDGRGAFVVIT
                     EEGRRVITTAAPGHVETVRRLFFDGLTRDQVAALERLAADVLDRLDQGASRDLLPPQRA
                     RQARQRSRDAT"
     gene            complement(19251..19856)
                     /locus_tag="HHX41_RS30700"
     CDS             complement(19251..19856)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012780.5"
                     /locus_tag="HHX41_RS30700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CBS domain-containing protein"
                     /protein_id="WP_169988738.1"
                     /transl_table=11
                     /translation="MLVREIMTTPVVTVRRTATIKQAVRLLYEQDITAAPVVDAAGRMV
                     GVVSEMDLLRGEFGANPRGFLRPEALPTGRPPALVEEVMTPRVATVGDGADTMDLVELM
                     ITTGVKSVPVTRDDELVGIVSRRDLMGLLAQGDERIREDVLAALRDCADTASFGAAVRD
                     GVVELYGPGDERSARIAELVARTVPGVADVVFPEGLVS"
     gene            complement(19868..20992)
                     /locus_tag="HHX41_RS30705"
     CDS             complement(19868..20992)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131093.1"
                     /locus_tag="HHX41_RS30705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CapA family protein"
                     /protein_id="WP_182908733.1"
                     /transl_table=11
                     /translation="MRSAAGDPVTLFLCGDVMLGRGVDQILPCPGDPALEESCVRDARE
                     YVELAEAANGPIPRPVGYSWPWGDALEVLDEAAPDVRVLNLETSVTRSRDFAPGKQVHY
                     RMNPANIPALAVARPDVCVLANNHVLDFGVHGLTETLDALAGAGLDQAGAGRDEDEAWR
                     PAVVALPGGGRVLVFAVAMSSSGVPGEWAAARDRPGVAYLPGPTRDAAAQTVRRVRQVK
                     QPGDIAVVSVHWGSNWGYEVEDDQVEFAHALAEGGVDLVHGHSSHHPRPAEVYRDRLIL
                     YGCGDFIDDYEGITGYEQYRDDLRLLYFVTADAATGRLLELRMAPMRAVRMRLRHARRE
                     DREWLLATLDGICREFGARVGPAPGGTLALAPAA"
     gene            complement(20994..21707)
                     /locus_tag="HHX41_RS30710"
     CDS             complement(20994..21707)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS30710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_182908734.1"
                     /transl_table=11
                     /translation="MTSRTRSRTTADGDLTRLPDRACRLVETLGGRFSREMGIDVDRGD
                     REVERWLLAATLFGARISAAIAVRTYRAMAEAGVRGISDVEGRTWEELVEILDRGGYAR
                     YDYRTATRLLRLAESVGGEVGALRGGGLDETRAALHALPGWGPVTVALFLRELRGVWPG
                     VDPPPDDRAVEAGRHAGLLGAEPHPLDRLREIAAEAGLDVRDLEAALVRLWLAHHKGFP
                     HCPGGARCAVLTEEG"
     gene            complement(21751..22698)
                     /locus_tag="HHX41_RS30715"
     CDS             complement(21751..22698)
                     /EC_number="2.7.6.1"
                     /GO_component="GO:0002189 - ribose phosphate
                     diphosphokinase complex [Evidence IEA]"
                     /GO_function="GO:0004749 - ribose phosphate diphosphokinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540941.1"
                     /locus_tag="HHX41_RS30715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribose-phosphate pyrophosphokinase"
                     /protein_id="WP_169988733.1"
                     /transl_table=11
                     /translation="MTLRIVAGTANRPLAAAVAAALYREPSVPVVERFPDGESRPVVTG
                     VRGADVYLVQPTGPPVDEHVMEALLLADACRRAGAARLTAVMPYVGYARQDRRRREGEA
                     IGLRVVVAALASAGVERLIAVDPHTAALEAVCPMPVETLTAVPALARTAGCGLPEDAVV
                     VAPDLGAVTLARHYAGLLARPVALVRKTRLTGADVRAEQVFGDVTGRPALVVDDMISTG
                     ATIVAAVEALLAQGAAPPFAVAATHGLFAGNARERLGGAEIRSVIRSLVVTDTLPQDHA
                     ALPSLEVCPVAPLLAEAIGRLHRDEGMDDLLSGA"
     gene            complement(22830..23642)
                     /locus_tag="HHX41_RS30720"
     CDS             complement(22830..23642)
                     /NRPS_PKS="Domain: oMT (39-138). E-value: 3.2e-07. Score:
                     20.6. Matches aSDomain: nrpspksdomains_HHX41_RS30720_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074933.1"
                     /locus_tag="HHX41_RS30720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_182908735.1"
                     /sec_met_domain="PCMT (E-value: 4e-12, bitscore: 39.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANETAVYTHGHHESVLRSHRWRTAANSAAYLLGALKPHMRILDV
                     GCGPGTITADLAELVPRGEVIGVDSEPGVLERARREAEGRGLANVSFATTDVHALGYPD
                     ASFCVVHAHQVLQHVGDPVSALREMRRVTKPGGIVAVRDSDYAGFVWYPRIPALDDWLD
                     LYRRVARANGGEPDAGRRLRAWAREAGFTEITSSSATWCYATPEERAWWGGLWADRTVQ
                     SSYAGRAIEGGHATRDDLRRIAGGWREWAASEDGWFSVLHGEILCRVT"
     aSDomain        complement(23229..23525)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX41_RS30720_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="3.20E-07"
                     /label="HHX41_RS30720_oMT.1"
                     /locus_tag="HHX41_RS30720"
                     /protein_end="138"
                     /protein_start="39"
                     /score="20.6"
                     /tool="antismash"
                     /translation="MRILDVGCGPGTITADLAELVPRGEVIGVDSEPGVLERARREAEG
                     RGLANVSFATTDVHALGYPDASFCVVHAHQVLQHVGDPVSALREMRRVTKPGGI"
     misc_feature    23654..23670
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.2"
                     /tool="antismash"
     gene            23751..24704
                     /gene="ligD"
                     /locus_tag="HHX41_RS30725"
     CDS             23751..24704
                     /EC_number="6.5.1.1"
                     /codon_start=1
                     /gene="ligD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544719.1"
                     /locus_tag="HHX41_RS30725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-homologous end-joining DNA ligase"
                     /protein_id="WP_182908736.1"
                     /transl_table=11
                     /translation="MTSDEVRDGVTLTNLDQPLFDGAGATKRDLVDYLDAVRDRVIPVL
                     RERPLSVVRVRQGQAPFMQKNVPSYAPDWVRTVTLWAESSQRRVSYALCDDRRTLLWLA
                     NQRAVEYHPALVRAGEWDRPTHLVLDIDPPSAEAFPQAVAAARLVGRALADAGLAGAVK
                     TSGAKGLHVFVPLEAHTTEDVAAATRALGVRAERLDPALATTAFIREDRGDRVFVDSTR
                     SGGATVVAAYSPRVRPGVPVSFPVAWDDLDRVTPGDFTVRTAAGLLRESDPWAVLMPEP
                     QRLPRDLIEEGHTIPVARVQAMHEGKRRARARRATS"
ORIGIN
        1 caccagcggc gcgacgccag cgcggccagc acggcgccgg cggcgttgac cagtacgtcg
       61 tccaccgagg acacccggtc aagctgcagg acgtactggg cgatttcgac cgccatcgag
      121 cagcctgccc cgagcgccag gatccgcggc acggacgcca gcgccgcgaa ccgcatcggg
      181 gcgaagaacc ccagcgccgc gaagatcagc aggttgccgc cgatgccgat cggccccatc
      241 gtgagcaggt cccggagcgg gatcagactt acccggccgg ggacgatgcc ggcccccggg
      301 cccggcatca tggtgagcca tacgaacggc accgtcccgt agaccatgcc cacctcggcc
      361 agcgacgtcc gccactccga tgtggcgccg gcggcacgcc ggctgcgcgc cagagcccac
      421 accgccagag cggccagcgg cagcgcgacc agcatcatca gcagcacgcc gttctccgtg
      481 tcgtagcagc cgtgccaccg cccggcgaag cacttcggag cggacatcag gagcggccgc
      541 cgcacgacga acgccacgcc cgccaggccg aggatcgcca ggccgacgag cacgatcctg
      601 cgcgtgcggc ggggcggtgg agacagggat gcactccggt tcatcagccg cccgaccccc
      661 catcgggcga ggccccggtg atggcctgcg tctcccgccc gatcatgtcc tgcagcgaca
      721 cgccctcgga gtcgctgttg ccgaggatga cgccgaccca gccggtgtcc gggtagatgc
      781 tccagttggc gccgacaccg gggttgccgc cggcgcgctg gaacatccac tgaccgttga
      841 cgatgtcgat cgagatcccg tacgccccga acgacgtcgg tccgtgggga atcttggccg
      901 cggtgagcac gtcggaccag ggacggtcca gcaccgtgcc gtcgcccagc gcctgcgcga
      961 accggaccag atccggcgcg gtggcgaagc cgccgtcccc gggggcgtcg atgaagcagc
     1021 gccccggatt cttgcccagt acgtacgggg ccgggctgcc cttgtccagg ttgcggacgg
     1081 cgtccacctg gctgccgtcg gccagcgtca tgtacgggtg cgcgatgcgc ccgtcggtga
     1141 gccactgcgg cctggtgtag aaccccgcgc cggtcatgcc gcagcgcttg aagatgttct
     1201 cctggacgta gtcccagtac gtcgagccgg tcacggcctc cacgatcagc gcgggaatgg
     1261 tgacctcggc ctcctggtgg gtggtggagg gagtgcccgg gacacccacc agcctcgcct
     1321 gccgggcgcg ccgcacgtag tggtcgtgca cctccgcccg gctctggaag acacgccgca
     1381 cgtcctcgtc cgggctgtcc agcccggagg tgccggacag caggtggtgg acggtcaccc
     1441 gctcggcgac ctccgggtcg aagcccgtca ggtatttgcc caccgtgtcg gacagccgca
     1501 acctgcctcg ctgggccagt tgcagaatgg ccaccgcgtg gaacggcttg cctgccgaac
     1561 tgaggctgaa cgcggtgccc tcgtggttgg ggatcccctt ctccctgtcc gccatgccgt
     1621 agctgcggga cagcaccgtg cggccccggt gcgacagcaa caccacaccg gagaacttgc
     1681 cctcggcggc cagccgcgcg atgtaccggt cgtaggcccc gccgggcagg gtgtcccgcg
     1741 ggacccggtc gcgccgggac gagtcggtgg gagacgaggc ggcgtggccg gccccggcgc
     1801 tcaccagcgg cccgccggcc gccaccacgc cggcggccgc cagcccgccc catctgacca
     1861 gccgccgccg gtcgatgccc cgtgccgaat ccgagtccat gatcacggtc cttcctggat
     1921 cgacgaatcc ggcgctgata gtgattcgcg gtggttcatg cctccactga agacgcgagg
     1981 ctgttgcggc ggcgtatgcg gttttcgata cgtccgcgat acaccgggac ggccggcacc
     2041 gccccgatga gcgccacggc acacttgcgg gcatgacaac caccccccag gcggccacac
     2101 ggacaaccgc cgcccggcgt caccgtttcg ccgccttcct ggtcgacaat gtgatccttc
     2161 tcgcagccaa cactgcgacc gggctggtgc tggggatcgc cggtcagccc gaggccgacg
     2221 aggcggatta cctcaccacg ctgctcaacc cctacgcgga ggccgactgg cccctgcaga
     2281 tcgcgatcat cgccgcgggc gctgcctact tctgggtgca gcacgccctg tggggccaga
     2341 cgctcggtaa gcggctgtac cgcctgaagg tggtgcccgc cgggaccgga gcgacgctca
     2401 cccatcgcca ggtggggatc cggacgctcg tccaccccct cctgagttcg gcggccccgt
     2461 atctcgggcc ggtgctctat ctcgtcgacg ccctgtggat cttcggcgac cccgggcggc
     2521 gctgcctgca cgacgtcatc gccgggaccg tcgtggtgga cgtgcccgcc cccggcacga
     2581 aggcgtcgag gaggtccggt ttcctgatcg ggctcgtcgt cctcgtttcc gtcttcgccg
     2641 ccttcgtgct ggtcaccacg ctgctggcgg cgtagtcgcc gttcaccgct catcggccgg
     2701 gacgccgtac ccggacgccc ggaacaggaa ggaggcccag gagcggtagg gccgccacgc
     2761 ctcggccact ttccggtacg cagcgggcgg agcgtcctcc ggcaggccgt acgcctcgcg
     2821 caggatcgcg aacaggcggg gttcgtcgcc cgggaacgcg tccggcgcgc ccgcgccgcg
     2881 gatcaggatc aggccggccg agaacggccc cacgccgggc agggcccgca gctcggccag
     2941 cgcctcctgg gggtcgagcg cgcgcagatg ctcggcggtg agcacgccgt cgagcgccgc
     3001 gcgggccagc ccgcgcagcc actcctcctt ctgcgcgggc aggccgaggc cgcccgcctc
     3061 cagcaacgtc atgggcgggg ggaaggcggc gtacggctcc cggtccacgg tcacctgcgc
     3121 gccgtaccgc tccgcgatgc gctgtttgag ccgggcggcg acgagcatcg acgagcgctg
     3181 cacgatgacc gcccagcagg ccgcctccca ggggctccag aagcacaacg gccgcagtcc
     3241 ggggctcttc cgttgcaggt cgccgagcac cgggtcggcg tcacccgcct cggcgaagcc
     3301 ggagccgtcc acgtcgaggg acaggatgcg cgccacctcg ccccggatcc ccggcccggc
     3361 ggcccgcgtc gtggcgacgg cgaccccgtc cggcgcggcg gtcacggtca cgccgatcgg
     3421 cagccagtcg gactcggcgc agtaggcgaa gcacagcgcc cgcccgtcgg aggggagccc
     3481 gctggtggcc ggccagtcct cgacgaagcg caacgtggcg ccgaagtcga acgggccctg
     3541 tgccgtgagc gtgaaaccgt gcctggtcat gggcctcatc gtacgagccc ggacagacaa
     3601 aggatcttgc cgcacggttc ggccgccgcc cggccccgcc ctgccggggc gccacgagac
     3661 cccgccaccc tgcccgaaag atttcgggta gctagttgca agtttcactg ttgccatacc
     3721 actcttgttg cctattcttc cgttgcaccg gatttccgga gcaacacaaa ccggactaac
     3781 cagcacttat atccccatcg caaagcaggg catcgtggcg aaaatttcgg tgacgtgtgg
     3841 tgagtgcagg cgggatcacc ctgcccgacc tgcctgcccc gtcgtgcgag aggaaggtgc
     3901 ggcgtgacgg cggaggagta cacgcgccgg ctggcgcagt tgatctcaga ggtgtcggac
     3961 ggcgagatca ccgtcgagga ggtgctcgcc gccggtcact cgctgtcggc gctcggcctc
     4021 acctcgttcg cgcggatccg gctcatcgac gcgatcgagc acgctttcgg cgtcgagatg
     4081 gacctgagcg acgagctcgc ctccttcgag gacgtcggca ccctgtccgc cctggtggcc
     4141 cgggccccgg cagtcggagg gacggcagtc ggagggacgg cacgcgcatg gtgacggtgg
     4201 cgttcagcgg cgcgcgggac ggcgaggcgc cgctgacctg gggacagcga ctgatatggc
     4261 gggcggtcca cctgatgggc gacagccaga cgttcctgag ctgcccgtgg gtgctcccgg
     4321 tgtacggcag acgtgacgtc ggcagcgttc tggacgcgct gcgcgtactg ctcgaacgcc
     4381 acgagagcct gcgtacgacc ttcgccctca ctccggaggg gccggtgcag cgggtcgcac
     4441 gcggtggcga gctgaccgtg gacgtcgtgg aggcgggaca ggaccgggcg ctgcgggtcg
     4501 ccgagcgggt cgcgggtgag ctgggccgga cggccttcgt ccacgatcgg gacctgccgc
     4561 tgcgctgcgc cctcgtcgtc aagaacgacc gcccgatggc gctggcgatc gccttctccc
     4621 atctggcggt ggacttccag gcgctgaaca cgctctcgga ggagtggaag gtcctgctgc
     4681 gcggcgagaa accgccgccc gccgagtggc agccgatgga ccaggcggcc gcggagctcg
     4741 aggagccgta ccccgcccgc tcggccaagt ccatccgata ctggcactcc gtgctggcgg
     4801 acgggccgct cgacgtgttc gaccatccgc cgcgcgaggc ggacgacccg cggttcatcg
     4861 aggtcggcat ggagtcgacg gcgctcgccg tggcggcgca acggctggcg gagcgctgga
     4921 cgatcagcac gaccagtgtg ctgctcgccg cctgcgccac cgtgctggcc acggtgagcg
     4981 gccgcccgcg cgcggtcatg cagctcgtgc acagcaaccg ccgcgacccg cgcacccacg
     5041 cgatggtcgg caccgtggaa caggacggcc tgttcgtgct cgacctgccc gccacggact
     5101 tcgccgccgc ctgccgggcc gcgcagcggg gggcgctcag ggcgtaccgc aacgcgcact
     5161 acgacccgtt cgagatgcag gccatgcggg aggagatcgg ccgccgccgc ggccgggagc
     5221 cggacctcga cgccttcttc aacgacaggc ggaccgtcgg cacctggccg ggcctgcctc
     5281 ccgtcggccc tgacgaggac gtggcccgcc tcaccagtca gacccggacg tacgtcacga
     5341 acgcctggcc cggcgtccgg ttcaaggcgt tcttcacggt cgtctcggcc cccgacaccg
     5401 ggcagctcag cctcatcgtt gacaccgcct acctgccccg ggaggtcgcc gaggccatgc
     5461 tgcgcggagt cgaggccctg ctggtccgcg ccctcaccga ggacgtcccg atgaccgccg
     5521 tccccaaggt gtgcgggatc ggcccgtacg ccgggagccc gacctaaaga tcccaccgca
     5581 gttcctcccc gagcaatccg ccgccggcga cctcgtcgat cgcggcggcg atcggtggat
     5641 cgtccagtgc gaaccgttcg gcgagatgcc gggccagcag gagcagggcg gcacgccggg
     5701 cggcctccgg ggcacgtcgc agccgggcgt cgaggtccgg gtccgcatgt ccgaaccgga
     5761 gccgttcgaa cggcgcgccg agcggaggat cgacgaggat cgcctgccgc gtgccgtcgc
     5821 cccactcacc gtccaggcag gcgccggtgg acaaccagcc cgggaacctc cgccaggatc
     5881 tcgccaccgg ccgcgaaggt cagccgttcg ccacgcacga acctcgtcgg ccgtcatcgg
     5941 cgtcctttga ttcgagggtg ggcgtcagga ctgctggacc gccaggcgca gaccgaagcc
     6001 gatgacgatg aggccggtga gccggtccag ggcgcgcttg accacgggcc tgcgcagcca
     6061 gccccgcatc atgccggtga acccgatgag cacggcgctc cacacgagcg cctcgcacac
     6121 gtggacgccc gccaggagca cgcccatcac cgcgtgcggc acgccctcgg gcatgaactg
     6181 gggcaggacc gcgacgtaga aggcgcccac cttcgggttg agcaggttgg tcagcaggcc
     6241 ccgccggaac gcctgtcccc acccggcgtc cgccgggccg ggcggcgcca cgtcgtccgc
     6301 ccggctgtcg cggctgtgcc agagcatcct ggcgcccatc cagatcaggt acgcgacgcc
     6361 cgcccaccgc agcacctcgt acgccacctg cgaggcggtg aggagcgcgg acaggccggc
     6421 ggccgtgagc aggccccaca gcagggtgcc ggcctggatg ccgagcacca cggcccaggc
     6481 cggcctccgg ccggcgagca gcgacgtacg caggatcagg gcggtgtcca gaccgggcgt
     6541 gagcgtgagg aatgccacga tgaccgcgaa cgaggcgagc gcaccattaa tgtccacgat
     6601 cggtcaccgt agcccacgcc cacatctgcg catggcggga ttccgggcgc aggggatgtt
     6661 cggattttca cggcagacca cagaaaggaa ccgcggttta gcatcgaaag catggacgaa
     6721 ccaatgccgg tcaggcttgc ggacggccgc gatctgaaat gcgacacgtg tgagaacgag
     6781 ctgttcgagc agcaccggtg gaagctgcag accacgggca tgacgttcat gaatctcgac
     6841 tgggccaacc gcgacgccac ctgcttcgtg tgcagcagtt gccgtcgcat ccactggttc
     6901 cactggtgat ctcgccgccg gatcgggcgg catcggcgac gcgtcacgcc gtgcgggaca
     6961 cgattacgac ggcgccagga ccaggaccgc gtggtcgggc gccacgctcg ccagccggag
     7021 acggatgtcg ccgatcctgc cgggccgtcc catggccagc gtcagcccgc cttcggtgcg
     7081 gcagcggccg ttgacgcagt cctgactgac gtcggtgttc atgccctcga cgcggaaggt
     7141 ccccccgccc gcttcgaaac gcagccgcac ctcgccccgg tcgacagaga cgaccgtgat
     7201 cacgtcgagg ccggtcttcc ggtcgagccg cagccggtcc cccgggcgga cctccacctc
     7261 gcagtccgcg cgtcggcacg cctgcgggtc gtccgcggcc ctgacgaccg aaggggcggg
     7321 cgagggcgag gccgctgcgg ggaccgtggc cgtcgccggg ccacccgggg cagcgggccg
     7381 cgaccgcacc tcaggctgcg gcgtcccgca cgccgtgagc agcacggcca tcggtacggc
     7441 gacgaggccg gcccggccga tcaggcggga cgcgtacggc cttggacaca tgactctccc
     7501 ccgcgacggc tgtgccgttc catggcaccg gcgaccggcc gtctccgccg cggcgggcag
     7561 gcccgggccc gatgctcaac gtggtcgagc cttccccgag cccggcggcc ccaatccgaa
     7621 gatcgggagt cacaggctga gggcgccggt gatctggcgg gcggtcctgc gcacggccgc
     7681 gcccaggcgc ggcagcgccg ccgtccccac cgctcccgcc ggggccgcga ccgcgacagc
     7741 catgcacacc ccgccgtccg ggccgaagac cggcgcggcc gcgcagcaca cgccctcggc
     7801 gaactcctcc cgcgcgtaac ccacgccctc ccctcggacg gcggcgagtt cacgttccag
     7861 cgcggccggg ccggtcaccg tgcggcccgt caccgtgcgg ccggtcaccc gccgcagggc
     7921 cggggcggcg aggaacgccg tacgcaggcc cgcgtcgtgg gcgaggagca ccttgcccgc
     7981 ggccgtgcag tacagcggcg cccggtccag gccgtcggag ggtgatttga cccggttgtg
     8041 cccgtacagc cgctcgacgt acgcgacctc gaacccgtcc ggcacggcca ggttgaccgt
     8101 ctgccgggtc gcctcgtaca gctggagcag gtgcggcagg accgccttgc gggagccggg
     8161 caggcggcgc ccctggaccg cccagccgcg cggcgccacg aggtcggcga cgcggccgcc
     8221 gaccgtgtag tcgccgcccg tgcgcgtgac caggccccgc cgctgcaggg tcccgagcag
     8281 gcggtgggtg gtggttttgg agaacccggt ggaccggtgc acctgggtga ggttcatcgg
     8341 ccgcatgccg gcggccaggc acaggagaat ctcgatcccg cgttccaggc tgcccagggc
     8401 ggaggccgcc tccgcccggc gatccgacgc tacgaacaag cccaccccac cacgctcgtg
     8461 atccggatca tgaccggcca gcggtcaccc tagtcgcgcc tcgccacgca tgcggggaga
     8521 acgcggttac tccgcgggag ccgccggccc ggcccggcgg ccggcttcgt cgcaccggct
     8581 caccggccgg gtcctcaccc tcggcggcgg tctggggctc ccccgaagcg ccggccggag
     8641 agcttcatcg ggcccccggc cggcgccggg cctcagttca cctcgacgct ctccagtacg
     8701 ccgagggcgt cggggaccag gacggccgcc gaatagtagg tggtcaccag gtaggagatg
     8761 atcgccttgt cgtcgatgtc catgaagcgc accgacaggc cgggctcgta ctcgtccacc
     8821 agcccggtgc ggcgcaggcc gaccacgccc tgcttctcgg cgccggtgcg catcaccacg
     8881 atcgagctga gcccgccctc ggtgatgggg atcttgtcgc agggcaggat cggcaccccc
     8941 cgccacgcca tgaccgtcgc cccgttcacc tcggtgacgt ccggatacac cccgcgccgg
     9001 gtgcactgcc gtccgaaggc ggcgatggcc cggggatggg cgaggaagta gtgcgagctg
     9061 cgccgccggg cgagcagctc gtcgaggtcg tcgggggtgg gcgggccgga gcgggtgtgc
     9121 acgcgctgct tgagatcggc gttgtgcagc aacccgaagt cgcggttgtt gaccagctcg
     9181 tgctcctgac gctcccgcaa cgcctcgatc gtcagccgca actgctgctc ggtctggttc
     9241 atcggctcgt tgtacagatc cgccacccgc gaatgcaccc gcagaatcgt ctgcgccaca
     9301 ctcaactcgt actcacgcgg ccccagctcg taatccacga acgtccccgg cagcgtcgcc
     9361 tcaccctcat gccccgccgc cagcgcgatc tccgcctcgc cgtaccggtt caccggccgc
     9421 gccacggggg gacggccgag atgctcgcgc aggccgccgg acaacgcggt caggttgtcc
     9481 agcgccgacc gctcgaggac gagaacgatg caggaggtga gggccttggc gggcgcggcg
     9541 cccgggccgg tgaggtctcc caggtggtct ccgtcggcca ggacctggag cagggcctcg
     9601 ccgccgtacg cgccggcgcc gacgcgtgcg atcttgccgt gggcgacgag caccacctgt
     9661 cccggcggca ccggctcgcc cgggcgcagg tcgtgctgga cgaaccggtc cgccagcgct
     9721 ccaagggtgt ccaggtcgcc gtagtcgtgc agggacggca gttcacacag ctcgggcggg
     9781 acgacccgca cccgcgcccc ggtggagacg aagctcaccc gcccgtcccc caccgtgcag
     9841 gtgagccggc ggttgacccg gtagacgccg ccctggacct ccgtccacgg cagcacccgg
     9901 agcaggtgcc gcggagtgat ctcccgcatc tgcggcggcg tcttggcggt ggtcgccagg
     9961 ttccgcgcgg cggccgtgct cagggtcaga cgtggcgcgg tcatggcgcc cccaccggga
    10021 gcggatcagc cggcgccgcg agatcggacg acgcgagagt gggcgccgtc acggacgacg
    10081 ccgtgagcgc cggcgaccgg tgagcgggcg gcgccaggga gaggatgcgt gcggtggccg
    10141 tgccgaggcc cgtcggaccc tgggaccacc gggccgccgg acccctgcgc agttcctcct
    10201 cgaagtagcg ccgggaccgc tcgtgccagc gcaggatcgc cgccatccag ttgcgcaggt
    10261 cggacacgta tccctcgacc gacctccgca cgtcctcccg cgcctcgatg cggtcgagca
    10321 gggcgggcag gtcgacggtg gtgatgtgct cgaactgcct catcctgctg gtcatgagcg
    10381 cgtccaccac ggtcaccgcc tcgtcgggcg cgcagccgag gaaggtgccc agcaccacga
    10441 cggcgttgtg cagctccccc tcgaactgga tctccttctg gtaggagaac aggtcgttca
    10501 gcaggcacgc gtagtcctgc gcggcatcgg tcatgcccag gaactcgcgg gtgcggtgga
    10561 tctccatggg gatgacccgg cccggcgcca gcctggccag gctcatcgtc atctgcgagc
    10621 cgaacgtcct gcgccgcatc tcgatgtagt cgatcggctc gggcacgcgg tgctgggcct
    10681 ggttggccag ctcccacacc cagctgtcga tcatctcctc gacggcggcg cggaaggccc
    10741 ggcgggagcc ctcgggcagc ggcccggcgg tgcgcggcca caggtcggcc agcccgcgtt
    10801 ccagcccggt catcggggtc aggcgcggaa cgaggtccag cggcatgaac tccttgagcc
    10861 gccggttgcc gagcttcgcg ccgaccaggt cgcgggccgg cccgtagacc cgcggatagt
    10921 agtcgtcgcc gtacgtcccc caggccagcc agttggtggc caggatcagt tcgccggccg
    10981 tggcgtccgg gttgatgccg gacgcgcaca gggcgaggtc gaaaccgacg agttgcggtt
    11041 cggtccacac ggcggtcgcc ggaatcccgg ggaccccgtc gaagaaaccc atggcggcac
    11101 accattcgac gtccgccgtt cgcgccgcgt ccaggtgcgg gttgtcgcgc acctcgaacg
    11161 gcatgtacgg cttcggccgc cgtaccgaga cctgctggta cggcgtgtgc gtgtggttgc
    11221 gcaggccgcc cgcgcccgtg aggtgggcgc gggagacgtt gacgccgagc ggcccgggga
    11281 ggctcccgga cttggtgtag cgactggagg cggtgtgcca cgcgtgtcct cccgcctgcc
    11341 agtcctgcag tcctttcacg tagctcagga ccggcgcctg ctcgggcggc aggacccctt
    11401 cgtcggcgaa gagggccgca agctcggtca gcgcggtgtg ctcgaactgg tgcagccggg
    11461 aggtgagcag atcgttggtg atctccacgg cccgcgcggt gtcgcagccg aagaagcgct
    11521 cgcagaccag cacgcagttg gacagctcgc cctccttcag cacctcccgc tcgtaggaga
    11581 acaggtcgtt gcgcaggtgc acggcgtcgg cgaacgactc cgtcagcacc cggaccggcc
    11641 gggagcccgc cagccgggcc ggcagttccg cgccggccgc gtgctccacc agcgcggccg
    11701 accacggggc gccgccgacc ttcctgcgtt cctcgatgta ctcgatcggg ttggagacgg
    11761 cctcccgctc gatgtggaac agctcccaca tcgactcctg caggaggtca cgggtgaccc
    11821 ggacgaaccg gcgccgccac gcctccgaca tggcgggcac cgtcctgggc cacaggtcgg
    11881 ccagtccccg ctccaccggg ttcgtcggct cgggcgggtc gtccgacatg aacgcgtcga
    11941 gccggtccag gtagtcctgg gcgccgtcca ggtccctgct gcgcttgaac gtctccagga
    12001 agtggtcgtc gaagtagaag acccacacgt accagtccgt gaccaggtcc agttcggggg
    12061 cggagcagtc gggatgggtg taggcgcaca tcaggccgta gtccatcgcc tcgagcgact
    12121 cctcggtcca gatgtccggg tcgtcgagca tgcccatgtc cgccgcccac ctccgggtgt
    12181 gcgcccgggc ggtctccacg tgcgggttca gccggggcgg ataggggagg tagaagtccg
    12241 gcagccggta ggaggacatc agaggacctc gacactctcc aggatggcga gggcgtcggg
    12301 gaccaggacg gccgccgaat agtaggtggt caccaggtag gagatgatcg ccttgtcgtc
    12361 gatgcccatg aagcgcaccg acaggccggg ctcgtactcg tccaccagcc cggtgcggcg
    12421 caggccgacc acgccctggt ccttctcccc caggcgcatg accatgatcg agctgatgcc
    12481 cttgtcgttg accgggatct tgttgcacgg cagcatcggc acgccgcgcc aggccggcgc
    12541 cttctggccg ctgaactcca ccgtctgcgg gtagatgccc ctgctgttgc actggcgggc
    12601 gaaggccgcg atcgccttgg ggtgggcgaa catgacgctc gggttcttcc acaccatggt
    12661 gagcagctcg tcgaggtcgt cgggggtggg cgggccggag cgggtgtgca cgcgctgctt
    12721 gagatcggcg ttgtgcagca acccgaagtc gcggttgttg accagctcgt gctcctgacg
    12781 ctcccgcaac gcctcgatcg tcagccgcaa ctgctgctcg gtctggttca tcggctcgtt
    12841 gtacagatcc gccacccgcg aatgcacccg cagaatcgtc tgcgccacac tcagctcgta
    12901 ctcacgcggc cccagctcgt aatccacgaa cgtccccggc aacgtcgcct caccctcatg
    12961 ccccgccgcc agcgcgatct ccgcctcgcc gtaccggttc accggccggt ccgggtcccc
    13021 gtggtaggcc tgcacgtgct cacgcaggct gtccgacagg gtgagcagcc gttcgaactc
    13081 gtccctgccg agggtgagca cggtgcacgg cgtcacggcc ttgaccgtcc actcccatcg
    13141 cgcgtccgcg ttcaccagca tctgctcgcc gacgtactcg ccgtcggcca gcacgccgag
    13201 cagcgtctcg ttgccgtacg ccccctggcc gtgcttgtcc accttgccgt gagccaggag
    13261 cacgacctcg tccatcgggg tgccggcctc ggcgatgacc tggccggcct cgtactccct
    13321 ctgggtgaac aggtccgcca tcgcggcgag cacgtcgggg tcgccgaagc cgcgcagggc
    13381 gggaagctcg cacaactcgg cggagatgac ccgcacgtcc gccccggtcg agacgaacgt
    13441 cacccgcccg tcggccatct ggtaggtcag ccgccggttg acgcggtagg cgccgcccac
    13501 cgcctcgatc cacggcagca cgcgcagcag atgacgggag gtgatctcct gcatctgcgg
    13561 cggggtcttg gtcgtcgtgg ccaggttgcg cgcggccctg gtgctcaggc tgagccggtt
    13621 gtcgttcggc atggtggttt cggtcacagc acttcacccc atctgttgtc ggcacggcgg
    13681 ccggtgtttc ggtgactggt cacgctcgtc gccgagcggc ggagggggag aaaaggtcag
    13741 agtcgttccg gccggggacg gccccggccc gcgtacggcc ccgcgcgggc gcaccagacg
    13801 caccgggcgc ggcgggtggc cgtacgaccg ggcgtggagc aggccggagt ggtcgcggcg
    13861 gcggaagtcg tgggagaggc gggcgtaccg gtcgcacgcc tcaccggacg cggcgggtga
    13921 gccgctcggt gagcaccgcg agcgcccgtg ccgcctccgg ggcgatcgcc tcgtcgcgca
    13981 gcgcctcgat cgcctgcccg gcccgcaggg cgatgagctc ctcgacctcg tcgagggcgc
    14041 cggtgtccac gatgacccgc cggagctcgg ccgcccgccg ctcgtccaga cccgggtcgc
    14101 cgtgccaggt ccgcagcagg tcccgttcgg gtccccgtgc ccgtgcgtac gcgtgcgcca
    14161 tgagcacggt ccgcttgccc tcacgcaggt cgtcgaggac cggcttgccg gtgacggcgg
    14221 gatcgccgaa gacgccgagg acgtcgtcgc gcagctggaa cgcctccccc agcggcagcc
    14281 cgaaccggga gtaggcctcc agcagagcgg gcggcgcccc ggcgagcgcc ccgccgatct
    14341 gcagcgggcg ctccaccgtg tagcgggcgg tcttgtagcg gatcaccatc agggcctgtt
    14401 cgacgtccgc gtccgcgcgc gtgtgcgcca ggatgtcgag gtactgcccg gtgacgacct
    14461 ctgtgcgcat ccggttgaac aactcgcgcg ccgcccgccc gcgcacgtcg ccggtggtgg
    14521 cgtccgcgag cagctcgtcc gcccacgcct gcgcgagcac gccgagcagg atcgcggcgg
    14581 accggccgaa ggtctccgct cccggccacc gcggagcccg ggcgagcccc ctgtggatgg
    14641 tcgggcgtcc acggcgcagc tcgctgccgt ccatgacgtc gtcgtggatc agcagaccgg
    14701 cgtggtagag ctccagcgcc gcaccggtga cgacggcccg gtcctcgtgc ggctcctcgc
    14761 cgccggcgcc ccgccagccc cagtagcaca gcagcggccg gacgcgctta cctccctcga
    14821 cgacgaactc gcgcagcagc cggtagccct cggcgacgtc cgggtcgccg accgggggac
    14881 gcctcgcgtc gaggaaatcg gccagcagtt cgtcgacccg cctccgtacc cggccggtca
    14941 tgccggtgat ggacgtgtcc acgattcccg ccgtcatggt cggtctcctc cgctcgacga
    15001 gccggtaccc cttgcggaaa gttacttaat gaacacgcaa agtagaacct cccgttccga
    15061 tagccggaac ttctcgccac tcagtccgct ctgccgaatg tgtgatcacg gagatcctca
    15121 agcgcatggc cgcgggcctg accgacgagg cgatcgcgct gcggctctgc aagcactctc
    15181 atgaaggacg agcctggtga ggctcccgcc gtcggcaacc cgattccgtc gtcgactggg
    15241 ccgggttgca gttccgagca gaaccggcga cgacggaccc cgctcagcga caggttctcg
    15301 tggcgacgtc gtcgaaatgc cggcagtcga accgggcgac gctctcggcg tcccagccgt
    15361 gcaggacgaa actcgcagcc cctgtcttga tcggaacacc ctgagccgtc agcagcccgc
    15421 ggaaggtgag gtgcacgccg tcgtactcac gggcgacagc cctccagtcg acgagagacc
    15481 ggccatcctc acatgtggca tatctactca ctaacgaccc gacgtccgcg gggcggtcga
    15541 tcgtgaagat cctcacgttc tccggctcga aggcaaggga gtattcggtg agctgggcgg
    15601 ggtcggcagg aacgtaggaa ctctcgatgg cggcttgcca cgagctgcgc ccccggtcga
    15661 ccagcgacga tgtccagagc ctgtacggtg agatcgcgaa cttcggcacc ggtgcggaat
    15721 tccgcaggca ggatcacggc gaccgatccg cccttctgcc gccgctgcga gcaggcggtg
    15781 tgttcccgca atccacatct ccagcgccga tcctcggcaa cacctcgggg gctggtcccg
    15841 tcttcccgga aggatcggat tcaattcagg cgggtggcac cggagtggca aggtgaagaa
    15901 tgagtggttc ccgtgccatc acactcgccg gccagggcgg agaacttccc ggaccgccgt
    15961 cgatgacgaa ccagtcggcg tggaaaagag gcagaacagc tccgttgata tcgacacgag
    16021 gagcggattc gatgctgctc ccccttttcc cgtgacgcca gtcgtcccag gggcttcccg
    16081 gcacgtcgtc tcgggacccg cagcccgccg tcgtcgccga gatcacgaga agaagcgtga
    16141 ggcgaggagc gaaggacgcc atccgtcagc caccttttca tgggcgtcgg gcggcggaga
    16201 ttctccgccg cccgcgaatc gtcgggccgt tctccgaaat ccgccaccag ggcgggggtc
    16261 agcaggtgat gtctcgctcg gtgctgtcca tgctgcctcc gaacttcgcc ccgctcgccg
    16321 agtcgtagta gccgctgcca tgccccatgt aggtgccgtc tgtacaggtg ttggcgctgt
    16381 tggtactcac gtaggatttg ttgtaaaccg tcttgtctcc gcggggcgca tactgcgtcc
    16441 aggcccagaa atcatccttg agcaggtcaa cggtgacgcg tacccgaggt tgggcgctag
    16501 gaagccggca gggcggccag gctcgtccgt cagctgagga tgcggccgtg gcggtcgcgg
    16561 gctttcagtc gcacggtggg catctcgggg gcgggcagcc gacgctcccc gccagggacg
    16621 acgccgaagc ggtcgccccg cgcccagtcg tcgcgcgccc gcgcgatctc ctcgtgcgaa
    16681 cggccgacga agttccacca catcaccagg ggctcctcga acggcgtgcc acccagcacg
    16741 aacagccggg ccgggccggc cgcctcgatc gggacctccg tacggccccg gccgaggtag
    16801 agcagcgagc ccggtgccag cgcgaccccg gccacgtcgg ccgtgcccga catggccagc
    16861 accgccgtct cgaaggccgg gtccaccggc agcctgtgct ctcccggtcc cgcgaacagc
    16921 acctcggccc cgagcagcgg ggtgtgcacg agggcgggcg agcgcagcgg cccggcctcc
    16981 cccaccacga cggtcaccgt gacgttcccc tcgcgtagca cgggcagcgc ggcgtggtgc
    17041 tcgaaccgcg cctccccgtg ccgggcgtcc tccggcagcg cgacccacaa ctgcagcccg
    17101 tgcatgcccg gcgggtgctc ctgcggcgac tgctccgagt gggcgatgcc gtgggcggcg
    17161 gtcatcaggt tgagctgccc gggcacgatc ggctggacgt tgccgaggct gtcgcggtgc
    17221 aggatctccc cctcggcgag ccacgtgacc gtctgcaggc cggtgtgggg atgcggcggc
    17281 acctgcatgc ccggccggcc gctcacgtcg tcgggtccga agtggtcgac gaagcaccac
    17341 gcgccgacca tgcggcgcgg gcgctgcggg agcagccgcc gcacggtcgt gtaccggccg
    17401 agcggcacgt cgtggccggg catgagcacg ctctccggct ccgcttcggt cgcgcccgtg
    17461 ccgccgtgca acacggtgca gccgtacaac gccgactccc cggggctcac ttcgatccct
    17521 ccccgccgtc gagggagaac cgggcccgcc ggtcggcggg caccagatcg aggtactccg
    17581 ggtgccgcgc gatgtaccgc tgcacgaacg ggcagaacgg caggaccgac agccccgcgt
    17641 cgcgggcggc gtcgagcgcc gcgcggacca gcgtcgagcc gaggccccgg ccctcgaagg
    17701 ccgggtcgat ctcggtgtgg gtgagggaga tcgccggtcc cttgagccgg tagtcggcga
    17761 agccggcgag ggcgccgtcc acggtgatct cgaagcggct cgcctccggg ttgtcggcga
    17821 cctgcggttc cgtctgtgcc atgggatttc cttccgggat cgtcaggcgg cgatcgtcgc
    17881 gtgcatctcc cacacgagga tctcggcggg ctcggtggcg gtgaccttct gcccaccggt
    17941 ggcggtgaag cgtacggcgt caccggtctc cagggtgccc gcgccctcca gggtgacgct
    18001 tccccggggg acgaacaggt gcaggaacgg cgcctcgggc agttccacgg tctggcccgg
    18061 ctggagacgt gcggcgtaca gcgcggcgta ccggttcttg atccggatgg cggcctcgcc
    18121 gtcgtgcttg tccatgccgc tggcgaccgg caccaggccg ccggccagca gctcgttctc
    18181 gatctccagc tgctcgtagc cgggagcgat gccgggctcg tcggggacca cccacatctg
    18241 gacgaagtgc acgggcttgt cgtgcgtgtc gccgccggtc agccgccagg agtcgttctt
    18301 ctccgagtgc aggatgccgg tgccggcgct catgcgctgg gccaggccgg ggtagatgac
    18361 gccgttgtgg ccctcggagt cctggtggac cagggacccc tggagcaccc aggtgacgat
    18421 ctccatgtcg cggtgcgggt gcgtctcgaa gccggtgccc gggtggacga cgtcgtcgtt
    18481 gttgaccagc agcagcccgt ggtgggtgtt gccggcgtcg tagtggccgc cgaacgagaa
    18541 cgagtgcttg gaatccagcc aggagatgcg ggtcgcgaaa cggtctgccg cccggcggat
    18601 gtccacacga ggggtcagcc tggtcgtggt catgagtgcc ctttcctcgt cgccatgtag
    18661 atgatgcgtc atctactggt gctcctcaac atacatgacg agtcattgat tccggatagc
    18721 ctgggagaca tggacagccc acggtggctc gacgcggacg agcagcgcgc ctggcgggcg
    18781 tacctgcgca tgcagggccg cctcacggcc cggctgaacc ggcaactgca ggccgactcg
    18841 ggtctgtccc tggcggacta cgaggttctc gtgcacctca ccgaccggga ggaagggcgg
    18901 ctgcggccgt tcgagctgca gcgcgacctc cagtgggagc agagccggct gtcccaccac
    18961 ctgacccgga tggagcgccg ggggctcgtc agccgggagg agtgcgcgga cgacggccgc
    19021 ggcgcgttcg tcgtgatcac ggaggagggc cgccgggtca tcaccacggc ggcccccgga
    19081 cacgtggaga ccgtgcggcg cctgttcttc gacgggctca cccgcgacca ggtcgccgcg
    19141 ctcgaacggc tcgccgcgga cgtcctcgac cggctcgatc agggagcgtc ccgtgatctt
    19201 ttgccgccgc aaagagcgcg gcaggcgagg caacgatcac gggacgcgac ctaactgacg
    19261 agcccctcgg ggaagacgac gtcggcgacg ccggggacgg tacgggcgac cagctcggcg
    19321 atgcgggccg accgctcgtc tcccggaccg tacagctcga ccacgccgtc gcgcacggcc
    19381 gcgccgaagg acgccgtgtc ggcgcagtcg cgcagcgccg cgagcacgtc ctcgcggatc
    19441 cgctcgtcgc cctgggccag caggcccatc aggtcgcgcc ggctgacgat ccccacgagt
    19501 tcgtcgtcac gcgtgacggg cacgctcttc acgcccgtcg tgatcatcag ttcgaccagg
    19561 tccatggtgt cggcgccgtc cccgacggtg gcgacgcgcg gcgtcatgac ctcctcgacg
    19621 agtgcgggcg gcctgccggt gggcagggcc tcggggcgca ggaacccccg ggggttggcg
    19681 ccgaactcgc cgcgcagcag gtccatctcg ctgacgacgc cgaccatccg cccggccgcg
    19741 tcgaccaccg gcgcggccgt gatgtcctgc tcgtacagca ggcggacggc ctgtttgatc
    19801 gtcgcggtgc gccggaccgt caccaccggc gtcgtcatga tctcgcggac cagcatgtga
    19861 ccacctccta cgcggccggc gcgagggcga gcgtgccacc gggcgccggt ccgaccctcg
    19921 cgccgaactc ccggcagatc ccgtcgagcg tcgcgagcag ccactcgcgg tcctcgcggc
    19981 gggcgtgccg cagccgcatc cgcacggccc gcatcggcgc catccgcagc tcgagcagcc
    20041 gccccgtcgc ggcatcggcc gtcacgaagt acagcagccg caggtcgtcg cggtactgct
    20101 cgtagccggt gatgccctcg tagtcgtcga tgaagtcgcc gcagccgtag aggatcagcc
    20161 ggtcccggta cacctcggcc ggccggggat ggtgggagga gtggccgtgg acgaggtcga
    20221 cgccgccctc ggccagcgcg tgcgcgaact cgacctggtc gtcctcgacc tcgtagcccc
    20281 agttggaccc ccagtggacg gagacgaccg cgatgtcccc cggctgcttg acctgccgta
    20341 cgcgccggac cgtctgcgcc gcggcgtcgc gagtgggccc ggggagatag gcgacgccgg
    20401 gccggtcccg ggccgccgcc cattcgccgg ggacgccgct ggacgacatc gccacggcga
    20461 agaccaggac ccgtccgccg cccggcaggg ccacgaccgc gggccgccac gcctcgtcct
    20521 cgtcccgtcc cgcgcccgcc tggtccagcc ccgcccccgc cagcgcgtcc agcgtctccg
    20581 tgagcccgtg tacgccgaag tcgagcacgt ggttgttggc cagcacgcac acgtcgggcc
    20641 gggccacggc cagggcaggg atgttggccg ggttcatccg gtaatgaact tgcttgcccg
    20701 gcgcgaagtc acggctgcgg gtgacactcg tctccaggtt cagcacgcgc acgtcggggg
    20761 cggcctcgtc gaggacctca agggcgtcgc cccagggcca ggagtagccg accgggcgcg
    20821 ggatcgggcc gttggccgcc tccgccagtt cgacgtactc ccgggcgtcc cggacgcacg
    20881 actcctccag cgcggggtca ccggggcacg ggagtatctg gtcgacgccc cggcccagca
    20941 tgacgtcacc gcacaggaac agcgtcaccg ggtcccccgc cgccgaccgc atctcacccc
    21001 tcctcggtga gtaccgcaca gcgggcgccg cccgggcagt gggggaagcc cttgtgatgg
    21061 gccagccaca ggcggacgag ggcggcttcg aggtcgcgca cgtccagccc cgcctcggcg
    21121 gcgatctccc gcagccgatc gagggggtgg ggttccgcgc cgagcagccc ggcgtgccgc
    21181 ccggcctcca ctgcccggtc gtccggcggc gggtccactc ccggccagac gccgcgcagc
    21241 tcgcgcagga acagcgcgac cgtcaccgga ccccagccgg gcagcgcgtg cagcgcggcg
    21301 cgggtctcgt ccaggccgcc cccgcgcagc gcgccgacct cgccacccac cgactcggcg
    21361 aggcggagca ggcgggtggc cgtgcggtag tcgtaacggg cgtagccgcc gcgatcgagg
    21421 atctcgacca gttcctccca ggtgcggccc tcgacgtcgg agatcccgcg cacccccgcc
    21481 tcggccatcg cccggtaggt ccgtaccgcg atcgcggcgg agatccgggc gccgaacagc
    21541 gtcgccgcga gcagccaccg ctcgacctcg cggtcccccc ggtcgacgtc gatgcccatc
    21601 tcacgggaga accggccgcc cagggtctcg acgagacggc acgcgcggtc cggcaggcgg
    21661 gtcaggtccc cgtccgccgt ggtacggctc cgcgtcctgg atgtcacact cctatcctcc
    21721 cccctggccg cccgccgcca ccgggcggcg tcaggcgccg gacagcaggt cgtccatgcc
    21781 ctcgtcccgg tgaaggcggc cgatcgcctc ggccagcagc ggggcgaccg ggcacacctc
    21841 cagcgacggc agggccgcgt ggtcctgcgg cagggtgtcg gtgacgacca ggctccggat
    21901 cacgctccgg atctccgcac cgcccagccg ttcccgcgcg ttcccggcga acaggccgtg
    21961 cgtcgcggcg acggcgaacg gcggcgccgc tccctgggcg agcagggcct cgacggccgc
    22021 cacgatcgtc gcacccgtgc tgatcatgtc gtccacgacc agcgcggggc ggccggtgac
    22081 gtcgccgaag acctgctcgg cccgcacgtc cgccccggtc agccgcgtct tgcgcaccag
    22141 cgcgacgggc cgcgccagca ggccggcgta gtggcgggcg agcgtgaccg cgccgaggtc
    22201 gggcgcgacc accaccgcgt cctccggcag cccgcacccg gcggtgcggg cgagggcggg
    22261 cacggccgtc agcgtctcca cgggcatcgg gcacaccgcc tccagcgcgg ccgtgtgcgg
    22321 gtcgaccgcg atcaagcgct cgaccccggc cgaggcgagc gcggccacca ccacccgcag
    22381 cccgatcgcc tccccctcgc ggcggcgccg gtcctgccgg gcgtacccca cgtagggcat
    22441 gaccgccgtc agccgggccg cgccggcccg gcggcaggcg tcggcgagca gcagcgcctc
    22501 catgacgtgc tcgtcgacgg gcggcccggt gggctggacg aggtagacgt ccgcgcccct
    22561 gacaccggtg acgaccggcc gcgactcgcc gtccgggaac cgctcgacca ccgggacgga
    22621 cggctcccgg tagagcgcgg ccgcgacggc ggcggcgagc gggcggttgg ccgtccctgc
    22681 cacgatccgc agcgtcatcg ctgttccccc ctcaaggccc cactggcacc gtcccccgtc
    22741 ggcgccggag gcaagcacgc cgcggccgtg gcggggctgc gggggccgtt ccccggcatt
    22801 cacagccgtt cccccggcgt tcacccgggt caggtcacgc ggcagaggat ctcgccgtgt
    22861 aggacgctga accagccgtc ctcgctcgcg gcccattccc gccagccgcc ggcgatccgg
    22921 cgcaggtcgt cccgcgtggc gtgtccgccc tcgatcgcgc ggccggcata ggaggactgg
    22981 accgtgcggt cggcccacag gccgccccac caggcccgct cctcgggggt ggcatagcac
    23041 caggtggccg acgacgaggt gatctcggtg aagcccgcct ccctggccca ggcgcgcaga
    23101 cggcgcccgg cgtcgggctc gccgccgttg gcgcgggcca ctcgacggta gaggtccagc
    23161 cagtcgtcca gggccgggat ccgcggatac cacacgaaac cggcgtagtc ggagtcgcgg
    23221 accgccacga tcccgcccgg cttggtcacc cgccgcatct cgcgcagcgc gctcaccggg
    23281 tcgcccacgt gctgcaggac ctggtgggcg tgcacgacgc agaaggacgc gtcggggtag
    23341 ccgagcgcgt gcacgtcggt ggtcgcgaag ctcacgttgg ccaggccgcg cccctccgcc
    23401 tcgcggcgtg cccgctccag gacgcccggc tcgctgtcga caccgatcac ctcgccccgc
    23461 ggcaccagtt cggccaggtc ggcggtgatc gtgcccgggc cgcagccgac gtccaggatc
    23521 cgcatgtggg gcttcagcgc acccagcagg tacgccgccg agttggcggc cgtacgccag
    23581 cggtgggagc gcagaacgga ctcgtggtga ccgtgggtgt acacggccgt ttcgttcgcc
    23641 atgccggcca cggtttcaca cgtctcgcta tttgagcaaa tatgtctcat atattgagcg
    23701 aatatctgag ggcgttgatt ccggcggccg gtcacgggca tggtgatcgg atgaccagcg
    23761 atgaggttcg cgacggagtc acgctgacca acctcgacca gccgcttttc gacggcgcgg
    23821 gcgcgaccaa gcgcgacctg gtcgactacc tggacgcggt tcgcgaccgc gtcatcccgg
    23881 tgctgcgcga gcgcccgctg tccgtggtgc gggtgcggca ggggcaggcg ccgttcatgc
    23941 agaagaacgt gccctcgtac gccccggact gggtgcggac ggtcaccctg tgggccgagt
    24001 cgtcacagcg gcgggtgtcg tacgccctgt gcgacgaccg gcgcaccctg ctgtggctcg
    24061 ccaaccagcg ggcggtggag tatcacccgg ccctcgtccg cgccggggag tgggaccgtc
    24121 ccacgcatct cgtgctcgac atcgacccgc cgtcggccga ggcgttcccg caggccgtcg
    24181 ccgccgcccg cctggtcggc cgggcgctgg ccgacgccgg cctggccggg gcggtgaaga
    24241 ccagcggcgc gaagggcctg cacgtgttcg tcccgctgga ggcgcacacc acggaggacg
    24301 tcgccgccgc cacccgcgcg ctgggcgtac gcgcggaacg cctcgacccc gccctcgcca
    24361 cgacggcgtt catccgggag gaccgggggg acagggtgtt cgtcgattcg acccggtcgg
    24421 gcggcgcgac cgtggtcgcc gcctacagcc cgcgcgtacg gcccggcgtc ccggtgtcgt
    24481 tcccggtcgc ctgggacgac ctggaccggg tcacgcccgg cgacttcacc gtgcgcacgg
    24541 cggcgggcct gctgcgcgag agcgacccct gggccgtgct catgccggag ccccagcggc
    24601 tgccccgcga cctgatcgag gaaggccaca cgatcccggt cgcccgcgtc caggccatgc
    24661 acgagggcaa acgccgcgcc cgcgcccgcc gcgccacctc gtgaggagtt tggcgacaca
    24721 gcgttgctat agttcgcgac atgtcgtcgc caaactcgcg ccagagctgg ctccccctgg
    24781 tcgtactcgc caccggcgtg tcgatggtcg tcgtcgacgc cacgatcgtg aacgtggcgg
    24841 tgcccgcgat catcgccgac ctcggcctcg gcgccaccga cgtggagtgg gtcaactcga
    24901 tctactcgct gatgttcgcg gcactgctca tcccgttcgg ccgtgccggt gaccggtacg
    24961 gcagacgccg cctgttc
//
