LOCUS       NZ_JABBXA010000018     25042 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H13382 NODE_18, whole genome shotgun sequence.
ACCESSION   NZ_JABBXA010000018
VERSION     NZ_JABBXA010000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H13382
  ORGANISM  Microbispora sp. H13382
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 191265)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 191265)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Antibiotics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014161445.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 07:22:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,906
            Genes (coding)                    :: 7,786
            CDSs (with protein)               :: 7,786
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 21 of 121
            Pseudo Genes (incomplete)         :: 104 of 121
            Pseudo Genes (internal stop)      :: 8 of 121
            Pseudo Genes (multiple problems)  :: 11 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:45:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 97376
            Orig. end                         :: 122418
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBXA010000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25042
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25042
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25042
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15042](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15042)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(351..361)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            356..733
                     /locus_tag="HHX41_RS29440"
     CDS             356..733
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027097.1"
                     /locus_tag="HHX41_RS29440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_182908552.1"
                     /transl_table=11
                     /translation="MAIQATAQRTFSFLRIAIILQTLTIFLQAVSAGLLLTASYGETLH
                     SAGARVMYGASLLYLLAAVLAWKPGGGSPRPVWHAAGFLVLASVQVVLGIAHVPAAHLP
                     LGVLMFGLSVLALARPRRSHV"
     gene            complement(730..1179)
                     /locus_tag="HHX41_RS29445"
     CDS             complement(730..1179)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS29445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169982583.1"
                     /transl_table=11
                     /translation="MTDPVPPAGVLSGHVLDLDAVVHLIEGKSMYGRAVVRQSSAHGVT
                     LLVPALAVQVLSLGPIQPRLERFLRMSMVVTGALSPDDAVEGGPYAQAIMASLRRHRPA
                     AADAHLPDVLVAAHAAVHATRRGWRIITATPYLYEGLDIRLEILP"
     gene            complement(1176..1409)
                     /locus_tag="HHX41_RS29450"
     CDS             complement(1176..1409)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS29450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169982584.1"
                     /transl_table=11
                     /translation="MTKKITISLPDELADEAQASGNASAYIAAALRERRRIQGDLAIMA
                     DLWGPGWQDGITDDDSARAARLMTGGAKADAA"
     misc_feature    complement(1269..1271)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1406..2461)
                     /locus_tag="HHX41_RS29455"
     CDS             complement(1406..2461)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012863.5"
                     /locus_tag="HHX41_RS29455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_182908553.1"
                     /transl_table=11
                     /translation="MGDSISHGLEGDYTWRYRLARHFAACGAPVRFAGPWTGTCALPDL
                     APEEGAAGVRAGGYRPGIVFPGDRHHARWGGLMDEARGGVADAVAAHRPDHLMVALGFN
                     DLAWGVSGPERLLAHVGEFVRRAREARPDLRFLVADVVRRTPLPHLPHLPGIVETYNAR
                     LPGVLAALSTPGSPVVPVGLAAVYDPYTDTYDGLHPNSVGEFKIAKAFADAYSRAFHGG
                     RPAFATPVPAVAEPLPIRPPGEIAVALHGSTARVSWSRVFGASGYWLDLRDVDAGTGFE
                     RSPLPIAACGCDLRLPGDGTYEVRVSAARGDQETAPTRAVRFACRVPAATPALFREPVD
                     RRQYDWVASQV"
     gene            complement(2512..2979)
                     /locus_tag="HHX41_RS29460"
     CDS             complement(2512..2979)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS29460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169982586.1"
                     /transl_table=11
                     /translation="MTAGPGAGRRSPFFIAVLTFLAAFLLFLAVPSIGPVVRAARADGV
                     PGSFTARQVECVRHPGHESCTWTGDFRSSDGAVLRTGVALYGADREMLREGQRTPAVDV
                     GRQNRVYGPGGSMEWVFTALLLLAALGILYAAYGRPVRNLLGARTTATAGR"
     gene            complement(2984..3550)
                     /locus_tag="HHX41_RS29465"
     CDS             complement(2984..3550)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893363.1"
                     /locus_tag="HHX41_RS29465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_169982587.1"
                     /transl_table=11
                     /translation="MATEAVSAFHPSRRGGELNARHHRAALNVFAFIVVAHWAEHIAQA
                     VQVYVLGWKLPEARGVLGLPFPWLVTSEWMHYGYALLMLVGLIMLRHGFTGRARVWWNV
                     SLGIQVWHHFEHFLLLMQVLVGANLLGRPAPTSIIQLLVPRMELHLFYNTLVTIPMVVA
                     MILHRRPSTAERTLMACSCAPALAR"
     gene            complement(3747..4487)
                     /locus_tag="HHX41_RS29470"
     CDS             complement(3747..4487)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS29470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_182908554.1"
                     /transl_table=11
                     /translation="MYRKCRQLALATVFVSAMTAGGTAVLSGPALATDGYAIAGIAPQA
                     SEPGGSVQTTTYSYSESPLMMTAEQARAEEQSIVDQARAERDRIRAQGRADRDRIRAEA
                     RAERDRIRASEWQSSGSAGSDPPASYHDGSRTRSEYRSERYRARSVSYGTVRTAPVRYR
                     MRERLSELRVRESARTARVSKRVDERRSRLLERVSGRRDRLVKRVESRRSERVRETAYR
                     GGGRYEQQQFKSVRYERRSSFRTH"
     misc_feature    complement(4458..4460)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4905..5651
                     /locus_tag="HHX41_RS29475"
     CDS             4905..5651
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-167). E-value: 6.6e-13. Score:
                     40.9. Matches aSDomain:
                     nrpspksdomains_HHX41_RS29475_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540960.1"
                     /locus_tag="HHX41_RS29475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_182908555.1"
                     /transl_table=11
                     /translation="MRLAGARVLVTGASSGIGAATALELSARGARLVLSGRDEEALAGV
                     AARTGGEALPADLSDGTVDRGADLAVRAGRVDVLVACAGEGWSGPLARMSGGTAERVIA
                     VNLTAHLQLTRLLLPGMIERGRGHLVYVASIAGVVGVREEAVYAATKAGLLAFAESLRY
                     ELPAVGVTAVVPGVVDTSFFARRGRPYTRRRPAPVPPERVARAIAVAVERGRAEVYVPA
                     WLRLPARLHGAAPGVFRVLARRFGRP"
     aSDomain        4926..5405
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX41_RS29475_PKS_KR.1"
                     /evalue="6.60E-13"
                     /label="HHX41_RS29475_PKS_KR.1"
                     /locus_tag="HHX41_RS29475"
                     /protein_end="167"
                     /protein_start="7"
                     /score="40.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VLVTGASSGIGAATALELSARGARLVLSGRDEEALAGVAARTGGE
                     ALPADLSDGTVDRGADLAVRAGRVDVLVACAGEGWSGPLARMSGGTAERVIAVNLTAHL
                     QLTRLLLPGMIERGRGHLVYVASIAGVVGVREEAVYAATKAGLLAFAESLRYELPA"
     CDS_motif       4929..5015
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX41_RS29475_0001"
                     /evalue="5.50E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="HHX41_RS29475"
                     /protein_end="37"
                     /protein_start="8"
                     /score="22.2"
                     /tool="antismash"
                     /translation="LVTGASSGIGAATALELSARGARLVLSGR"
     gene            complement(5691..6371)
                     /locus_tag="HHX41_RS29480"
     CDS             complement(5691..6371)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.5"
                     /locus_tag="HHX41_RS29480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_182908556.1"
                     /transl_table=11
                     /translation="MSGLRERWRLKAMRTIQERALDLFDERGFGAVTIEEIAAAAEVSP
                     SSVYRIFGTKEGIVVADVEFDSMSPEALASILDPADPIGSLLRAVRAYESPPEGESGSG
                     NAGEGSQATRSPWRRVRYFFAEPSVRMAVCGTLDRASQRIAPLITVPGEVSETQARVIA
                     KALAFGYFAALEQWYLDGGNRPIADYVEEGMRPLRSIWSAPHASSERDHPGTSVPPPLS
                     SFTM"
     misc_feature    complement(6428..6442)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.36"
                     /tool="antismash"
     gene            6504..6953
                     /locus_tag="HHX41_RS29485"
     CDS             6504..6953
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS29485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_182908557.1"
                     /transl_table=11
                     /translation="MTTLKQRSRTRTALAMMYIGAGLTSIAALFPFVDRATTTVLADHI
                     KAGYPAYAPGAIDTAVTAYLVILSVVGALGLLGWMGTIWAARAGKRWTFPLAIGLLGLA
                     LCVAIAALTVQDTSGDVGLAPLLGWLLVLPCVPGLAAVVLWRRAG"
     misc_feature    6550..6566
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.65"
                     /tool="antismash"
     gene            7136..7546
                     /locus_tag="HHX41_RS29490"
     CDS             7136..7546
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS29490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_211592046.1"
                     /transl_table=11
                     /translation="MGRRSGTITPVPVAVTHYRGADFLVSMLGPDASWVRNVEAAGGKA
                     ALRRQGRECPILLEEIPSEHRAQILRRYLAGAPGARPHLGLGPTAPLPEFHRIAPRHPV
                     FRIHERPGSYVPRRARRDSRSEPRVAKTAVGS"
     gene            complement(7474..8478)
                     /gene="hpnH"
                     /locus_tag="HHX41_RS29495"
     CDS             complement(7474..8478)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076658.1"
                     /locus_tag="HHX41_RS29495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_182908558.1"
                     /sec_met_domain="PF04055 (E-value: 8.8e-21, bitscore: 68.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3e-09, bitscore: 30.3,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPMPLRQSLRVGAYILRQRLRRRERFPLLLELEPLFACNLKCAGC
                     GKIQHPAGVLKQRMPVEQAVAAVEECGAPMVSIAGGEPLMHPQIGEMVEELVARRKYVF
                     LCTNALLIPRKIDRFEPSPYFAWAVHIDGLRERHDASVCKEGVFDEAVAAVRECRRRGF
                     RVTTNTTFFAGDSPRTVVEVLDFLNDELCVDQMMISPGYAYEKAPDQDCFLGVRQTREL
                     FRAAFAGGNRERWRFNHSPLFLDFLEGKTDFRCTAWAIPSYSVFGWQRPCYLMADGYAK
                     TYRELVEETDWDSYGRGRDARCANCMAHCGYEPTAVFATLGSLRESLRALRGT"
     misc_feature    complement(8464..8466)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8478..10004)
                     /gene="ispH"
                     /locus_tag="HHX41_RS29500"
     CDS             complement(8478..10004)
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /GO_process="GO:0050992 - dimethylallyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="ispH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076659.1"
                     /locus_tag="HHX41_RS29500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_182908559.1"
                     /transl_table=11
                     /translation="MTGLIVCTALGMEARAVARGLRPARDHPRVRVFRIGMGPERAARA
                     AALLPPAAALAVTGFGGALHEGLRPGDVLVATEVRSGGRVWPCPSAPLLAGELVRAGLP
                     ARTGPLVTSPGIVTGRARLALAREGACAVDMESALIAEAADGRPFAAVRVIVDTPGVPL
                     VNPATLGGALAARRALARIGPVLARWAAAVGPRRVLLASPRSFCAGVERAIEIVERALD
                     RFGAPVYVRKQIVHNIHVVRDLERLGAVFVDDLAEVPEGAVTVFSAHGVAPAVREEAAR
                     RGLRVVDATCPLVAKVHAEARRFAARGDLVVLIGHAGHEEVEGVLGEVPGAGVLVEDEA
                     GVEGAVEGLRPGRGVAYLTQTTLAADEAGRVAAAVRRRFPDAEGPRGDDICYATTNRQR
                     AVRAVAAEAGLVLVVGSANSSNALRLTEVAGRSGHDGAPLVRLVDGPGDVALDWLRGVR
                     TVGLTAGASTPGSLVDAVVAALGGLGPLEVEERRVIEENVEFTLPKEVRP"
     gene            complement(10001..11884)
                     /gene="shc"
                     /locus_tag="HHX41_RS29505"
     CDS             complement(10001..11884)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634144.1"
                     /locus_tag="HHX41_RS29505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_182908560.1"
                     /sec_met_domain="T2TS (E-value: 6.7e-149, bitscore: 490.4,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGVTTGVATGAARAETALEAARDHLLGLQSPGGWWKGELRTNVT
                     MDAEDLLLREFLGVRTARETAEAARWIRSQQRADGGWANFHDGPADLSTTVEAYAALRL
                     AGDPPSAPHMRAAAACARGAGGVESARVFTRIWLALFGQWRWEDLPVIPPEIMFLPPWC
                     PLNVYDWACWARQTIVPLTIVTAHRPVRPLPFALPELRAGHPPRRAARTGWDAAFAALD
                     RALHRYERRPLAGLRRAALRRAAEWVVARQEADGSWGGIQPPWVYSLIALSLSGYGLDH
                     PVMRAGLAGLDRFTIRENGTRRLEACQSPVWDTALAMTALLDAGLPRDHPALDRAGEWL
                     LREEVRGPGDWAVRRPGLAPGGWAFEFDNDGYPDVDDTAEVVLALRRWGRPDARPAVER
                     GLRWMAGMACRDGGFAAFDADNTRTLCLRLPFCDFGAVIDPPTADVTAHVVEALAAEGL
                     ARSPVVRRAVRWLLRAQEPDGSWFGRWGANHVYGTGAVLPALAAAGMPPGAPCVRRAVA
                     WLKAHQHPCGGWGEDMRSYRDPAWIGRGEPTASQTAWALIGLLAAGERGRSVDRGAAWL
                     AGSQRPDGTWDEPHYTGTGFPGDFFINYHLYRLVFPLSALGRYLRAREVTP"
     gene            complement(11881..13239)
                     /gene="hpnE"
                     /locus_tag="HHX41_RS29510"
     CDS             complement(11881..13239)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540955.1"
                     /locus_tag="HHX41_RS29510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_182908561.1"
                     /sec_met_domain="DAO (E-value: 5.2e-09, bitscore: 29.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGPTNGAGYDGVAPVAVVGGGLAGITAALALAEAGRPVTLYEAR
                     PRLGGATHSFARGGLTADNGQHVFLRCCTAYLGLLDRLGGIGRVRLQERFDVCVLTPHG
                     GRGRLRRAALPGPFHLLPALAGYRLLSPADRLRAVRGALALRGLDPAAPALDRAALGGW
                     LAANGQRDAVRRALWDLFAVAALNIPSDEAALGPAAMVFKTALLGRADAADIGVPSVPL
                     GDLHGGAALAAIARLGGEVRLRAKVDAVLPGPSVLVGGRRVEAPAVVVAAPHGQAARLV
                     PAEAAPDRDAWAGLGASPIVNVHVVYDRPVTRLPFAAVVGSPVQWIFDRTEAGGLARGQ
                     YLTVSVSAARHWIDVPTAVMREVFLPELERLLPAARAARVVDLFITRERRATFRQVPGS
                     GGLRPGAATRWPGVFLAGAWTDTGWPDTMEGAVRSGLQAARLVRRHLEREQAR"
     gene            complement(13236..14216)
                     /locus_tag="HHX41_RS29515"
     CDS             complement(13236..14216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152784.1"
                     /locus_tag="HHX41_RS29515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_310742243.1"
                     /sec_met_domain="phytoene_synt (E-value: 3e-51, bitscore:
                     167.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.1e-63,
                     bitscore: 208.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPGAIPDPVPDRPPGPALRPVGAGPARTPAPVPLPLAYRHCER
                     VVRTRARNFAYGIRLLAPPERRALCALYAFARRIDDIGDAAGPVDERLSALEEARAGLR
                     APRPDPTDAVLVALRDTAARFPVPLEAFEELIDGCAADVAGARYQSHDDLVGYCREVAG
                     SIGRLSLGVFGLADGPGRDPGALRRAARLADSLGVALQLTNVLRDLREDRCAGRVYLPA
                     DDLRRFGCTLGLDASGAFTDPPERLARLVRYEAGRALAWYAEGMRLIPLLDRRSAACTA
                     AMAGIYRRLLARIAADPAQALAGRLSLTPWAKAMVAARAIAGAAR"
     gene            complement(14191..15042)
                     /gene="hpnC"
                     /locus_tag="HHX41_RS29520"
     CDS             complement(14191..15042)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540954.1"
                     /locus_tag="HHX41_RS29520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene synthase HpnC"
                     /protein_id="WP_169982596.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.6e-44,
                     bitscore: 145.9, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 4.4e-40, bitscore:
                     131.2, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAADVRDAARRENFPVASRLLPRAYRLDLMAVYCFARYVDDVGD
                     EADPAERPALLNAVEADLGRLYAGGSPRLPAVRALTPLVAGRGVPRAHFLHLVEANRRD
                     QVVRRYDTFAQLLAYCELSANPVGRIVLHVFGAATPERARLSDRICSALQVIEHCQDVG
                     EDHARGRVYLPAEDLRRFGCREADLGAPHASPRLRRAVALQARRAATLLDEGMPLLETL
                     SGFARTAVAGYVAGGRAALAALERGRHDVLGRAVRARRRAVLGEWARVLKEVNGDGSRR
                     DS"
     misc_feature    complement(15039..15053)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.54"
                     /tool="antismash"
     misc_feature    15063..15076
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.34"
                     /tool="antismash"
     gene            complement(15214..15984)
                     /locus_tag="HHX41_RS29525"
     CDS             complement(15214..15984)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540953.1"
                     /locus_tag="HHX41_RS29525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_182908562.1"
                     /transl_table=11
                     /translation="MRPHALAAAGLALLHAGPGAAWLPPVRRLLPSLAGEGDPGHVALT
                     FDDGPDPRSTPLFLDELDRLGCRATFFLLGELLERHPEVGRSIARAGHEVAVHGWRHGN
                     ALVARPGRVAAEIGRAARLVAAVTGVPPSWYRPPYGVLSAEALLAARWHGLRPVLWTAW
                     GADWTARATPGSVLRTLEPGLRGGATLLLHDCDHTSAPGSWRSALGALAGVVGRCRAAG
                     LRVGPLGAHGVGVPGGAGAHRLPLPASFYPRPEA"
     gene            16032..17159
                     /locus_tag="HHX41_RS29530"
     CDS             16032..17159
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633008.1"
                     /locus_tag="HHX41_RS29530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MGDG synthase family glycosyltransferase"
                     /protein_id="WP_182908563.1"
                     /transl_table=11
                     /translation="MSNRTLIVSASMGAGHDAVAAELARRLTAAGVRAEIVDVLALLPL
                     RLGALLRWWYRVVMLRAPWLYALVYRVFFVSRRAPSTSPLTVVAAAGLARAVRRVRPSL
                     VVPVFHVAAQAAGHLRARGRLAAPSVVVLTDFAVHRLWLHPGNDRYLCPDAATALAVTA
                     ALGRPAFRCAPIVRPRFAAPRDRAGMADVRTRIGLRDGGPIVLVCAGSWGVGRVAETAG
                     ILARSGRYAPVVLCGRNERLRRRLARLLGRAGAGAALGWRDDLADLLASAYALVDNAGG
                     LTCREAFAAGVPVVTYRPIAGHGGDGVRAMARAGVSVHVRRRAELLRALDRLQPGLPGR
                     AALTARAAALFSASPAESLLLPDLAAASRSCEPAS"
     gene            complement(17083..17988)
                     /locus_tag="HHX41_RS29535"
     CDS             complement(17083..17988)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038012.1"
                     /locus_tag="HHX41_RS29535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DMT family transporter"
                     /protein_id="WP_182908564.1"
                     /transl_table=11
                     /translation="MIAVVLAVLAAAANAVASVLQRRAARAAPAAEAFRPGLIWDLVRR
                     PTWLGGIAALIAGFLLQAGALTSGGLALVQPLLVAELPITMLVAGWMFRVRLDPKTWLA
                     VGLLTAGLAGFLAAASPTPGHRLPGLLTWVISAGVTIGLLACCVTAAIALGGAARAVLL
                     GMAAGLGFAYTAVLMKRTVDELPAGARTLAGSWSLWAMVAAGLCSLFLLQNALHSGPLV
                     AVQPALTVTDPVASTAYGVAMFGEDIRTGPWVVPELTGMALILYGSVLLSRYAPLRRQA
                     HMIGTRRRGPGEEGTRPAKR"
     misc_feature    complement(17668..17670)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18133..18146
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.63"
                     /tool="antismash"
     misc_feature    18133..18146
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.98"
                     /tool="antismash"
     misc_feature    complement(18133..18148)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.4"
                     /tool="antismash"
     misc_feature    18134..18147
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.28"
                     /tool="antismash"
     misc_feature    18134..18148
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.06"
                     /tool="antismash"
     misc_feature    18134..18149
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.02"
                     /tool="antismash"
     misc_feature    complement(18135..18148)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.49"
                     /tool="antismash"
     misc_feature    complement(18136..18149)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.53"
                     /tool="antismash"
     misc_feature    complement(18136..18149)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.51"
                     /tool="antismash"
     gene            18220..18687
                     /locus_tag="HHX41_RS29540"
     CDS             18220..18687
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131916.1"
                     /locus_tag="HHX41_RS29540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SPW repeat protein"
                     /protein_id="WP_169982600.1"
                     /transl_table=11
                     /translation="MVGPTGLERHPDVTELRQTYDRAGSTAPAQVLEGLSFLAGLYLAL
                     SPWIVGFFGLRGLTVSNLVTGLVISALALGLASAYGRTYGLGWLLPLLGVWAIVSPFVV
                     RAGREATATTIWNNVAIGIVTLALGAAALAMAQAFRRHERGERSARRLGNW"
     gene            complement(18800..19711)
                     /locus_tag="HHX41_RS29545"
     CDS             complement(18800..19711)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892042.1"
                     /locus_tag="HHX41_RS29545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_169982605.1"
                     /transl_table=11
                     /translation="MLSSHRLKVLLEVFRTGSIAGAAKSLRLSPSAVSHQLARLEEEAG
                     VGLVERAAHSLRLTAAGHRLAGRAQEVLDLIESAEKDLLAQARADAGQLRIGFFASAGY
                     RLLPMALSSFTARHPGVVLDLVLGQPHELLTDVERGELDVLVVFEHALDPWKAPKGVEV
                     VHLFDEPQLLVMPLGHPVGSRPRVRLTDLADEPWITTFGTETPVSVLERASALEGFTPT
                     IRCRSDHYEVTLGLVRAGLGVALVPSLGVQGAAGIQVCQVEGQKLYRRVGAALRPTNPN
                     PALRAFVDYLRDASARLSVTLR"
     gene            complement(19746..20591)
                     /locus_tag="HHX41_RS29550"
     CDS             complement(19746..20591)
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541198.1"
                     /locus_tag="HHX41_RS29550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase"
                     /protein_id="WP_310742244.1"
                     /transl_table=11
                     /translation="MSGKDAGGVPGAARLAEAAAACPGTLAVCVPGLLGVNEDVVLPLA
                     STGKVLLLAALAQDVAGGVVDPDEPVPLLDEDYASGSGLLTDLSARVWTAGDLALLTAS
                     VSDNTATNALLRRLGLARVDAAAAALGLARTRIHDRIREPRLPVHPPAFATGTARELAG
                     LMRSLAHGREPWQRLLLGWMAHNTDRALVPALLPHEPEDRDPPVALPYAAGVWVANKTG
                     TDAGTRADVGVMAGTRWEGYAVLAHGPVGREHALVRAIRQAGLAVAASVLPPRWLGFPL
                     "
     gene            complement(20605..22221)
                     /locus_tag="HHX41_RS29555"
     CDS             complement(20605..22221)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892064.1"
                     /locus_tag="HHX41_RS29555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_182908565.1"
                     /transl_table=11
                     /translation="MTGFDLLIRGGLLVDGTGRPGRPADVGVAAGRLTVLAPGEAPRTG
                     GAAEVIDARGRVVSPGFVDVHTHSDGVTLLGPSGGGSGRALVRASVLQGVTTEICGNCG
                     SGLFPALPERLPAMRAEARITFGGDVGMYADFAGFAAAHARVLRANHLASLVGHGTLRA
                     GVLGPVDRPARPDELRAMCALLDASLSQGAAGLSTGLIYTPGSYAGTDEVVALAAVAAR
                     HGKPYVTHLRDEMSRVEEALEEAIEISRRSGAALHVSHHKTAGRYAWGRTERTLPRIAA
                     LRAEGMDITCDVYPYTAGSTALAAMLPPWANDGGLGALTARLGDPAERDRMRRAIAEGV
                     PGWENTVGNGGWDRISVACAPRHPQAEGRTIADLAASAGADPLDVAADLLVAEAGEVTI
                     ISHSMVEEDVRRVLAAPYTMIGSDGVPKPGGRPHPRWAGTFPRVLGRYVRELGLLRLEE
                     AVHKMTGMAAARFGLTGRGVIRDGAHADLVVFDPAAVADLATFTEPLLPPAGIDVVVAG
                     GQVVVRDGEETGARPGSVLAL"
     gene            complement(22218..22991)
                     /locus_tag="HHX41_RS29560"
     CDS             complement(22218..22991)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658361.1"
                     /locus_tag="HHX41_RS29560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_283246784.1"
                     /transl_table=11
                     /translation="MSGPDQPMVRIRAVRKRFGALEVLKGIDLDVPAGEVVCIVGPSGS
                     GKSTLLRCVNRLETIDSGRIWVNGELMGYAERGGRLHALRPAELSRQRRGIGMVFQRFH
                     LFPHRTAIENVMEGPVTVLGTRAAQARRQAEELLERVGLADRAHHYPAQLSGGQQQRVA
                     IARSLAMRPSLMLFDEPTSALDPELVQEVLAVMRDLAATGMTMMVVTHEMNFAREVGDQ
                     LVFMDDGVIVERGDPREVLSAPRHERLRTFLGQVR"
     gene            complement(22988..23902)
                     /locus_tag="HHX41_RS29565"
     CDS             complement(22988..23902)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633222.1"
                     /locus_tag="HHX41_RS29565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_310742245.1"
                     /transl_table=11
                     /translation="MEVTREQEAAAELPIEAVRPVRPGRWLGAAAALLFLVWLAYTVIV
                     NENLHWDVIVAYLADGRILGGLWVTIQLTVLSMAIGLVLGVLAAVMQLSDNPALRGTSA
                     LYTWFFRGTPLLVQLIFWFNIGLVFPAFAIGVPFGGPKLIEWQANEVITPFTAALLGLA
                     INEGAYMAEIVRAGIRSVDPGQREAAESLGMSHRQVLRRVVLPQAMRVIIPPTGNQFIS
                     MLKTTSMVSVIAGAELLTVAQRIYLGNFEVIAMLVVASIWYVVLTTIASVGQHFVEKRF
                     ERGHVRLSSRVRRNLRPLQKEPS"
     gene            complement(23893..24777)
                     /locus_tag="HHX41_RS29570"
     CDS             complement(23893..24777)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892067.1"
                     /locus_tag="HHX41_RS29570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_182908566.1"
                     /transl_table=11
                     /translation="MTKRLYVAIVGALVVSALAGGCGRSSSGTAAGENAAATTGKTAKD
                     LVPEDVRKTGTLRVATSEGYPPMEMYKKGTQELTGVDPDLGAAIAAKLGLKFSITNAAF
                     DGLIPGLQGGRWDIVMSSMSDTEERRAAVDFVDYFNAGGAIMVKKGNPDGIKNLEDLCG
                     RTVVLAKGSSNLAIGEKQNEKCATKMKIMQSEDAPTGLLSIDSGRAVATIVDYPVAVMY
                     AKDTGKYDVLPEQYDAGPWGIAVDKRKTALRDAVAKAMEELQADGGYKAVLDEYGVAAN
                     AVDGVLVNTQPWK"
     misc_feature    24865..24879
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
ORIGIN
        1 cgacatagcg ttcgcgccgg gcccgtgccg agcccagcag gtccaggcag acgcgcccgg
       61 tcaccgtcgt cagccaggcg ccggggaaca cgatctcctc ctgccggctt cgcggcagcg
      121 cgtaccagcg cgcgtaggcc tcctgtacgg cgtcctcggc ctcggccagc gaaccgagca
      181 accggtaggc gacattgatc agttggcgcc gctcaccggt tacctcatcg gtgctcgttc
      241 cagccgtccc catgctcccg gcggccccct cgccttacct ttcgcaggcc cgcgtcgtcg
      301 ggctggtgag accttatcga tctactgccc ccggggcgga acaggggacc gtgacatggc
      361 catccaggcg acggcacagc gcaccttctc gtttctgcgg atcgcgatca tcctgcagac
      421 cctgaccatc ttcctccagg cggtctccgc cggactgctg ctgaccgcgt cctacggaga
      481 gacgctgcac agtgccggag cccgcgtgat gtacggggcg tcgctgctgt acctgctcgc
      541 ggcggtgctg gcgtggaagc cgggcggcgg ctcgccccgg cccgtctggc acgcggccgg
      601 cttcctcgtg ctcgcctccg tccaggtcgt gctcggcatc gcgcacgtgc cggcggccca
      661 tctccccctg ggcgtcctga tgttcgggct gagcgtcctg gcgctggcgc gcccccgtcg
      721 ttcgcacgtc taggggagga tctccaggcg gatgtcgagg ccctcgtaca ggtagggggt
      781 cgccgtgatg atccgccagc cgcggcgggt ggcgtggacg gcggcgtggg cggccaccag
      841 gacgtcgggc aggtgcgcgt cggcggccgc cggccggtgg cgccgcaagc tcgccatgat
      901 cgcctgcgcg tacggcccgc cttcgacggc gtcgtcgggg gagagcgcgc cggtgaccac
      961 catcgacatg cgcaggaacc gttcgagccg gggctggatg gggcccagcg acagcacctg
     1021 gacggcgagt gcggggacga ggagggtgac gccgtgggcc gaggactggc gcacgacggc
     1081 cctgccgtac atgctcttgc cctcgatcag gtggacgacg gcgtcgaggt ccagcacgtg
     1141 gccggacagg acgccggccg gtgggacggg gtcggtcacg cggcgtccgc cttggcgccg
     1201 cccgtcatca ggcgcgccgc gcgggcgctg tcgtcatcgg tgatcccgtc ctgccagccc
     1261 ggcccccata aatcggccat gatggccagg tcgccctgga tgcgccgccg ctcccgcagc
     1321 gccgcggcga tgtaggccga ggcgttgccg gacgcctgcg cctcgtcggc cagttcgtcc
     1381 ggcaaggaga tcgtaatctt cttggtcata cttgggaggc tacccagtca tactgtcggc
     1441 ggtccaccgg ttcgcggaaa agcgcaggtg tggcggcggg cacacggcag gcgaaccgga
     1501 cggctctcgt cggcgcggtc tcctggtcgc cgcgggccgc gctcacccgc acctcgtacg
     1561 tcccgtcgcc gggcagccgc aggtcgcagc cgcaggccgc gatcggcagc ggcgagcgct
     1621 cgaatcccgt tccggcgtcc acgtcgcgca ggtcgagcca gtagccgctc gcgccgaaga
     1681 cccgtgacca ggagacccgg gccgtggagc cgtggagcgc cacggcgatc tcgccgggcg
     1741 ggcggatcgg cagcggctcg gcgacggcgg gaaccggcgt ggcgaaggcc ggccgcccac
     1801 cgtggaaggc ccgggagtac gcgtccgcga aggccttggc gatcttgaac tcgccgacgc
     1861 tgttggggtg cagcccgtcg taggtgtcgg tgtacgggtc gtagacggcc gcgaggccga
     1921 cggggacgac gggggagccg ggcgtggaca gggcggccag gacgcccgga aggcgcgcgt
     1981 tgtacgtctc gacgatcccc ggcaggtgcg gcaggtgggg cagcggagtg cgccggacga
     2041 cgtcggccac gaggaaacgc aggtccgggc gggcttcgcg ggcccggcgc acgaactccc
     2101 cgacgtgggc cagcagccgc tcggggccgc tcacccccca ggcgaggtcg ttgaacccca
     2161 gcgcgaccat gaggtggtcg ggccggtggg cggcgacggc gtccgcgacg ccgcccctgg
     2221 cctcgtccat gaggccgccc cagcgggcgt ggtgccggtc gccggggaag acgatccccg
     2281 ggcggtagcc gcccgcgcgc accccggcgg cgccctcctc cggcgccagg tcgggcaggg
     2341 cgcaggtacc cgtccacggc ccggcgaacc gcacgggcgc gccgcacgcg gcgaagtggc
     2401 gggccagccg gtatcgccag gtgtagtcgc cctccaggcc gtggctgatc gagtcaccca
     2461 cgatcatgat cgtcggacgc ggaatggcac gcctcccggg tggatcgtcc gtcaccgacc
     2521 ggccgtcgcg gtggtgcggg caccgagcag gttccgcacc ggccggccgt acgcggcgta
     2581 caggatgccg agcgcggcca gcagcagcag cgcggtgaac acccactcca tcgaaccacc
     2641 ggggccgtag acccggttct gccgccccac gtccacggcc ggggtccgct gcccctcgcg
     2701 cagcatctcg cggtcggcgc cgtacaacgc gacgccggtc cggaggaccg cgccgtcgga
     2761 cgaccggaag tcgcccgtcc aggtgcagga ctcgtgcccg gggtgccgga cgcactccac
     2821 ctgccgggcg gtgaaggacc cggggacgcc gtccgccctg gcggcccgta cgacgggacc
     2881 gatgctcggc acggccagga agagcaggaa ggccgcgagg aacgtgagga cggcgatgaa
     2941 gaacggggag cggcggcctg ccccgggccc ggccgtcacg ccgtcacctc gcgagcgccg
     3001 gggcgcagga gcaggccatc agcgtgcgct cggcggtgct gggacgacgg tgcaggatca
     3061 tcgcgacgac catcgggatc gtcacgaggg tgttgtagaa caggtgcagc tccatgcgcg
     3121 gcaccagcaa ctggatgatg ctggtcggcg ccgggcggcc cagcaggttg gctccgacca
     3181 gcacctgcat gagcagcagg aagtgctcga agtggtgcca gacctggatg ccgagggaca
     3241 cgttccacca gacgcgggcc cggccggtga agccgtgcct gagcatgatc agcccgacca
     3301 gcatcagcag cgcgtagccg tagtgcatcc actcggacgt gaccagccac gggaagggca
     3361 ggccgagcac gccgcgggcc tcggggagct tccagccgag cacgtagacc tggacggcct
     3421 gggcgatgtg ctcggcccag tgggccacga cgatgaaggc gaagacgttg agcgcggccc
     3481 ggtggtgccg ggcgttgagc tcccctcccc ggcgggaggg gtggaatgcg gaaaccgctt
     3541 cggtcgccat gcgcaaacct cgatccggga agggtggtct gcgggcccgg cacgggatca
     3601 cgggcccgta cgccccattg ttcgatcacg ctcgcgcggc gccttctccc atcgtgcggt
     3661 gtctcggtca ccggccggca cgcggacggc cccgcactcg cggagtgcgg ggccgtctct
     3721 gataccgggc ggtggcgccg aaccggtcag tgcgtccgga acgacgaacg gcgctcgtac
     3781 cggacgctct tgaactgctg ctgctcgtac cggccgccgc cccgatacgc cgtctcccgc
     3841 acgcgctcgc tgcgccggga ctccacccgt ttgacgaggc ggtcacgccg gcccgacacc
     3901 ctctcgagca ggcgggagcg ccgctcatcg accctcttgg acacccgcgc ggtccgggcc
     3961 gactccctca cgcgcagctc ggacagccgt tcccgcatcc ggtagcgcac cggggccgta
     4021 cggaccgtgc cgtagctcac cgaccgtgcc cggtagcgct cggaacggta ctcggaccgg
     4081 gtgcgtgagc cgtcgtggta cgaggcgggc gggtcggacc cggcgctccc ggacgactgc
     4141 cactcgctcg ccctgatccg gtcgcgttcg gcgcgggcct cggccctgat gcggtcccgg
     4201 tcggcccggc cctgggcccg gatgcggtcg cgttccgccc gcgcctgatc gacgatgctc
     4261 tgctcctcgg cccgcgcctg ttcggcggtc atcatcaagg ggctctccga gtacgagtac
     4321 gtcgtggtct gtaccgagcc gccgggctcg ctcgcctggg gcgcgatacc ggctatggca
     4381 taaccgtcgg tggcgagggc gggaccgctc aggaccgcgg tgcctccggc cgtcatcgcc
     4441 gagacgaaga cagtcgctaa tgccagctgt ctgcacttcc ggtacatggt gcctccttga
     4501 gcccgactgg gctgggcaga tcagatcacc agggtttcgt ggtcctggat ccggccgcgg
     4561 ctcacccctg ggtcgttccg tcggacgacg ggaatcggtg tgatggacga ggggtcggtt
     4621 tcgccaggcg gcatcgcgca ttacggcctt gtctcgatcc tccgccgggc cgcgcgaagc
     4681 cgtctagggc gtttgaccca agcgttccct ccggccttgg aggatctgac cgccgggggc
     4741 agtgctgcgg aagtatccgc cggggtgttt gcggccgctt gtacgcgcga gcagcttggg
     4801 gttgccccag cccttctccg gtcacatccg ccactcgcgg cacgtgcggc aagccgggcg
     4861 cctcccgcga ggcgggtaca cccagggacg agggggtggg gcggatgcgg cttgcggggg
     4921 cacgggtgct cgtcacgggc gcgtcgtcgg gcatcggcgc cgccacggcg ctggagctgt
     4981 cggcgcgcgg cgcgcggctg gtgctgtccg ggcgtgacga ggaggcgctc gccggcgtcg
     5041 ccgcccggac cgggggcgag gcgctgcccg ccgacctgtc cgacggcacc gtcgaccggg
     5101 gcgcggacct cgccgtacgc gccgggcggg tggacgtgct ggtggcgtgc gcgggcgagg
     5161 gctggagcgg gccgctcgcg cggatgtccg gcggcacggc cgaacgcgtg atcgcggtca
     5221 acctgacggc ccacctgcag ctcacccggc tgctgctgcc cgggatgatc gagcgcggcc
     5281 ggggccacct cgtctacgtc gcctcgatcg ccggcgtggt cggcgtgcgg gaggaggcgg
     5341 tgtacgccgc gaccaaggcg gggctgctgg ccttcgccga gagcctgcgc tacgaactgc
     5401 cggcggtcgg cgtgacggcc gtggtgcccg gggtggtcga cacgtcgttc ttcgcccggc
     5461 gcggccggcc gtacacccgc cgcaggccgg cgcccgtccc accggagcgg gtggcccggg
     5521 ccatcgcggt cgccgtcgag cgcgggcgcg ccgaggtgta cgtgccggcc tggctgcggc
     5581 tgcccgcccg cctgcacggg gccgcgcccg gcgtgttccg cgtcctcgcc cgccgcttcg
     5641 gccgcccctg agcgttcctc cgaggtgtac gactgccccg atctgatgat ctacatcgta
     5701 aaggaactca atgggggagg caccgaggtg ccggggtgat cgcgctcgga ggacgcatgc
     5761 ggtgcgctcc agatgctgcg tagtggccgc atgccttcct cgacgtagtc ggcgataggg
     5821 cggttgccgc cgtcgaggta ccactgctcg agtgcggcga agtagccgaa ggcgagggcc
     5881 ttcgcgatca cgcgagcctg cgtctcgctc acctctccag gcacggtgat cagcggcgcg
     5941 atccgctggc tggcgcggtc gagtgtgcca cagacggcca tgcgcaccga tggctcggcg
     6001 aagaagtaac ggaccctgcg ccacgggctc ctggtggcct gagagccttc gcccgcgttg
     6061 ccggaaccgg attcgccttc tggtggggat tcgtacgcac ggacggctcg gagcaggctt
     6121 ccgatgggat cggcggggtc caggatgctt gcgagtgcct ccgggctcat gctgtcgaac
     6181 tcgacgtcgg cgaccacgat cccttccttg gtgccgaaga tgcggtacac cgacgacggc
     6241 gagacctcgg ccgccgccgc gatctcctcg atggtgacgg cgccgaaccc tctctcgtcg
     6301 aacaggtcga gggcacgttc ctggatggtg cgcatggcct tgagtcgcca acgctcacga
     6361 agcccgctca tgtgctcacg gtagcaggca gtcacgctct caagcgtgtg actgctgtcg
     6421 ggacattgac tgtctgaaag cagatcccta cagtcacttg ctggagacag tgactttctc
     6481 tttactccgg aaggactcat gccatgacca cgctgaagca gagatcgcgc acccggaccg
     6541 cgttggcgat gatgtacatc ggggcaggac tcacctcgat cgccgccctc tttccgttcg
     6601 tcgaccgggc caccacgacc gtcttggcgg accacatcaa ggccggctac ccggcctacg
     6661 cgcccggtgc gatcgacact gccgtcaccg cctacctggt catcctgtct gtggtcgggg
     6721 cgctgggact cctgggctgg atgggcacga tctgggcggc ccgcgccggt aagcgctgga
     6781 ctttcccgct ggcgatcggg ctgctcgggc tcgcgctctg cgtcgcgatc gccgcactga
     6841 ccgtccagga cacctcgggt gatgtcggtc tggccccgct gctgggctgg ctgctggtcc
     6901 ttccttgtgt tcccggtctc gccgcggtcg tgctgtggag aagagcggga tgaccaaagg
     6961 tcccacggcg gcgcggagcg tcggccgtgc tctgacacgc ggggtcgccg cactcaagcg
     7021 tgcgatgtat cgaggagggc ggccgaacgc gctcatgcgg ctcgggaacc ggcttgacgt
     7081 cctgctgtat ggggctcggt ggctgtcacc gcgccgtgcc gccgtcttga aggtggtggg
     7141 gcgccgcagc gggaccatca cgccggttcc ggtcgcggtc acccactacc gcggcgccga
     7201 cttcctcgtc tcgatgctcg ggccggacgc gagctgggtg cgcaatgtcg aggccgcggg
     7261 cggcaaggcc gcgcttcgcc gtcaggggcg cgagtgtccg atcctgctcg aggagatccc
     7321 gtctgagcat cgtgcgcaga tcctgcgccg ctaccttgcc ggcgcgccgg gtgcgcggcc
     7381 tcacctggga ctggggccga cggcgccgct gccggagttc caccggatag cgcctcggca
     7441 ccccgtcttc cgcatccatg agcgccccgg ctcctatgtg ccgcgcaggg cgcgcaggga
     7501 ctcgcgcagc gagccgaggg tggcgaagac cgccgtcggc tcgtagccgc agtgcgccat
     7561 gcagttggcg cagcgcgcgt cccgcccccg gccgtaggag tcccagtcgg tctcctcgac
     7621 cagctcccgg taggtcttcg cgtacccgtc ggccatcagg tagcagggcc gctgccagcc
     7681 gaacaccgag taggacggga tcgcccaggc cgtgcagcgg aagtcggtct tcccctcgag
     7741 gaagtcgagg aacagcggcg agtggttgaa ccgccagcgc tcgcggttgc cgcccgcgaa
     7801 cgcggcgcgg aacagctccc gcgtctgccg cacgcccagg aagcagtcct ggtcgggcgc
     7861 cttctcgtag gcgtaccccg gcgagatcat catctggtcg acgcacagct cgtcgttgag
     7921 gaagtcgagc acctcgacga ccgtgcgcgg gctgtccccg gcgaagaacg tggtgttggt
     7981 ggtgacgcgg aagccgcgcc gccggcactc gcgcaccgcc gcgaccgcct cgtcgaacac
     8041 gccctccttg cacaccgacg cgtcgtgccg ctcgcgcagg ccgtcgatgt ggaccgccca
     8101 ggcgaagtag ggcgacggct cgaaccggtc gatcttgcgc gggatcagca gcgcgttggt
     8161 gcacaggaag acgtacttcc tgcgcgccac cagctcctcg accatctccc cgatctgggg
     8221 gtgcatgagg ggctccccgc ccgcgatcga caccatcggg gcgccgcact cctcgacggc
     8281 ggccaccgcc tgctcgaccg gcatgcgctg tttcagcacg ccggccgggt gctggatctt
     8341 cccgcagccc gcgcacttca ggttgcacgc gaacaacggc tcgagttcga gcagcagcgg
     8401 gaacctctcc cgccggcgga gccgctggcg caggatgtaa gcgccgacac gcaggctctg
     8461 gcgtaagggc atcggcatca gggtcgcacc tccttcggca acgtgaactc gacgttctcc
     8521 tcgatcaccc ggcgctcctc cacctccagc gggccgagtc cgccgagggc cgccacgacg
     8581 gcgtccacca gcgagccggg cgtcgacgcc ccggcggtca gcccgaccgt ccgcactccg
     8641 cgcagccagt cgagcgcgac gtcgcccgga ccgtcgacca ggcggacgag cggcgcccca
     8701 tcgtgacctg agcgcccggc gacctcggtg aggcgcaggg cgttggagga gttcgccgac
     8761 ccgacgacca ggaccaggcc ggcctccgcg gcgacggcgc gcaccgcgcg ctgccggttg
     8821 gtcgtcgcgt agcagatgtc gtcgccgcgc gggccctcgg cgtccgggaa gcgccgccgg
     8881 accgccgccg cgacccgccc ggcctcgtcg gccgcgagcg tggtctgggt gaggtaggcg
     8941 accccgcgcc ccggccgcag gccctcgacc gcgccctcca ccccggcctc gtcctcgacc
     9001 agcacgcccg cgccgggcac ctccccgagc acgccctcga cctcctcgtg ccccgcgtgg
     9061 ccgatcagca cgacgagatc gccccgcgcg gcgaacctgc gggcctccgc gtggaccttc
     9121 gcgaccagcg ggcaggtcgc gtcgacgacg cgcaggccgc gccgcgccgc ctcctcccgc
     9181 acggcgggcg cgaccccgtg cgcggagaag acggtcaccg cgccctccgg cacctcggcc
     9241 aggtcgtcga cgaacaccgc gccgagccgc tccaggtcgc gtacgacgtg gatgttgtgc
     9301 acgatctgct tgcgcacgta cacgggcgcg ccgaaccggt ccagcgcgcg ctccacgatc
     9361 tcgatggccc gctcgacccc ggcgcagaac gagcggggcg aggccagcag gacccggcgc
     9421 gggcccacgg ccgccgccca ccgcgccagc accgggccga tccgggcgag cgcgcggcgc
     9481 gcggcgagcg cgccgcccag ggtggcgggg ttcaccaggg ggacacccgg ggtgtccacg
     9541 atgacccgca cggccgcgaa cggccgcccg tccgcggctt ccgcgataag agcgctctcc
     9601 atgtcgacgg cgcaggcgcc ctcgcgggcc agggcgagcc gggcgcggcc cgtcactatc
     9661 cccggcgagg tgacgagcgg gccggtgcgg gcgggcagcc ccgcccggac gagctctccg
     9721 gcgagcagcg gggccgacgg gcacggccag acccggccgc cggagcggac ctcggtggcg
     9781 acgagcacgt ccccgggacg caggccctcg tggagggccc cgccgaagcc ggtgacggcg
     9841 agggcggcgg cgggcgggag caaggccgcc gcgcgcgccg cgcgctccgg ccccatcccg
     9901 atccggaaga cccggacacg ggggtggtca cgcgcgggcc gcaggccgcg ggcgacggcc
     9961 cgcgcctcca tccccagcgc ggtgcacacg atcaggccgg tcatggcgtc acctcccggg
    10021 cacgcaggta gcggccgagc gcgctgaggg ggaagacgag gcggtagagg tggtagttga
    10081 tgaagaagtc gccggggaag cccgtcccgg tgtagtgcgg ctcgtcccac gtgccgtcgg
    10141 ggcgctggct gccggccagc caggccgccc ccctgtccac ggaccggccg cgctccccgg
    10201 cggcgagcag gccgatgagg gcccacgccg tctgcgaggc ggtcggctcg ccccgcccga
    10261 tccacgcggg gtcgcggtag gagcgcatgt cctcgcccca gccgccgcag gggtgctggt
    10321 gggccttgag ccaggccacg gcccgccgta cgcagggggc gccgggcggc atcccggccg
    10381 ccgcgagtgc gggcagcacc gcgccggtgc cgtacacgtg gttggccccc catctgccga
    10441 accacgagcc gtcgggctcc tgcgcccgca gcagccacct cacggcccgc cgtacgacgg
    10501 gggagcgggc caggccctcg gcggccagcg cctcgaccac gtgcgcggtc acgtcggccg
    10561 tcggcgggtc gatgaccgcg ccgaagtcgc agaacggcag ccgcaggcac agcgtgcggg
    10621 tgttgtcggc gtcgaaggcg gcgaaccccc cgtcgcggca ggccatcccg gccatccagc
    10681 gcagcccccg ctccaccgcc gggcgggcgt cgggccggcc ccaccggcgc agcgcgagga
    10741 ccacctccgc cgtgtcgtcg acgtcggggt agccgtcgtt gtcgaactcg aacgcccagc
    10801 cgcccggcgc gagcccgggc cgccgcaccg cccagtcgcc aggcccgcgc acctcctcgc
    10861 gcagcagcca ctcgcccgct ctgtccagcg cggggtggtc gcggggcagg ccggcgtcca
    10921 ggagggcggt catcgcgagc gcggtgtccc agaccggcga ctggcacgcc tccagccggc
    10981 gcgtgccgtt ctccctgatg gtgaacctgt ccagcccggc caggccggcc cgcatgacgg
    11041 gatggtccag gccgtacccg ctcaggctca gggcgatcag cgagtagacc cagggaggct
    11101 ggatgccgcc ccaggagccg tcggcctcct ggcgggccac gacccactcg gcggcccgcc
    11161 gcagcgcggc gcggcgcagc cccgcgagcg gccgccgttc gtaccggtgc agggcgcggt
    11221 cgagcgccgc gaacgccgcg tcccagccgg tacgcgcggc gcggcgcggc ggatgcccgg
    11281 cccgcagctc tggcagggcg aacggcagcg ggcggaccgg ccggtgcgcg gtcacgatcg
    11341 tgagcggcac gatggtctgc cgcgcccagc aggcccagtc gtagacgttc agcgggcacc
    11401 acggcggcag gaacatgatc tccgggggga tgaccggcag gtcctcccac cgccactggc
    11461 cgaacagggc gagccagatc cgggtgaaga cccgggccga ctcgacgccg ccggccccgc
    11521 gcgcacacgc cgccgcggcg cgcatgtgcg gagccgaggg cgggtcgccc gccaggcgca
    11581 gcgcggcgta cgcctcgacc gtggtggaca ggtcggcggg accgtcgtgg aagttggccc
    11641 agccgccgtc cgcccgctgc tgcgacctga tccaccgggc tgcctcggcc gtctcccgcg
    11701 cggtccgcac gccgaggaac tcacgcagca ggaggtcctc ggcgtccatc gtcacgttgg
    11761 tccgcagctc gcccttccac catcccccgg gcgactgcag gccgagcagg tggtcacggg
    11821 ccgcctcgag ggcggtctcg gcgcgggcgg cgccggtggc gaccccggtg gtgacgccgg
    11881 tcaccgcgcc tgctcccgtt cgagatgccg cctcacgagg cgggccgcct ggagtccgct
    11941 gcgcacggca ccctccatcg tgtcgggcca gcccgtgtcg gtccacgcgc cggcgaggaa
    12001 cacccccggc caccgggttg ccgcgccggg gcgcagcccc ccgctcccgg ggacctgccg
    12061 gaaggtcgcc cgccgctccc tggtgatgaa caggtccacg acccgcgccg cccgcgcggc
    12121 cggcagcagc cgctccagct cgggcaggaa cacctcccgc atcaccgccg tgggcacgtc
    12181 gatccagtgc cgcgccgccg acaccgagac cgtcaggtac tggccccgcg cgagcccgcc
    12241 cgcctcggtc ctgtcgaaga tccactgcac cggtgagccg acgacggcgg cgaacggcag
    12301 ccgggtgacc ggccggtcgt agaccacgtg cacgttgacg atcgggctcg caccgaggcc
    12361 ggcccaggcg tcccggtcgg gcgccgcctc cgcggggacg agccgcgcgg cctggccgtg
    12421 cggggcggcg acgacgacgg ccggcgcctc gacccgccgg ccgcccacga ggactgaggg
    12481 ccccggcagc accgcgtcca ccttcgcccg cagccgtacc tcgccgccca ggcgggcgat
    12541 ggccgcgagc gcggcgccgc cgtgcaggtc gccgagcggc acggacggca cgccgatgtc
    12601 ggcggcgtcg gcgcggccca gcagggccgt tttgaagacc atcgccgccg gccccagcgc
    12661 ggcctcgtcg gacgggatgt tgagcgccgc caccgcgaac aggtcccaca gcgcccggcg
    12721 tacggcgtcc cgctggccgt tggcggccag ccagccgccg agcgcggccc ggtcgagggc
    12781 gggcgcggcc gggtcgagcc cgcgcagcgc gagcgcgccg cgcaccgcgc gcagccggtc
    12841 ggcgggggac agcaggcggt agcccgcgag cgccgggagc aggtggaacg gcccgggcag
    12901 cgcggcccgg cgcagccgtc cccgcccgcc gtgcggggtg agcacgcaca cgtcgaaacg
    12961 ctcctgcagg cgcacccgcc cgatcccgcc gagccggtcg agcaggccga ggtacgccgt
    13021 gcagcagcgc aggaagacgt gctgcccgtt gtcggccgtc aggccgcccc tggcgaagga
    13081 atgggttgcc ccgccgagcc ggggcctcgc ctcgtacagg gtcaccggcc ggccggcctc
    13141 cgcgagcgcg agggccgcgg tgatgccggc gaggccgccg cccaccaccg ccacgggcgc
    13201 aaccccgtcg taaccggcgc cgttcgtcgg gccgttcatc gggccgctcc cgcgatcgcg
    13261 cgggccgcga ccatcgcctt cgcccagggc gtgagcgaca ggcgcccggc cagcgcctgg
    13321 gccgggtcgg cggcgatgcg ggcgagcagg cgccggtaga tgccggccat cgccgcggtg
    13381 caggccgcgc tgcgccggtc cagcagcggg atcaggcgca tcccctcggc gtaccaggcg
    13441 agcgcccgcc cggcctcgta ccggacgagc cgcgccagcc gctcgggcgg gtcggtgaac
    13501 gcccccgacg cgtcgaggcc gagcgtgcag ccgaacctgc gcaggtcgtc ggccggcagg
    13561 tacacccgcc cggcgcaccg gtcctcacgc aggtccctga gcacgttggt gagctgcagc
    13621 gccaccccca gggagtccgc gagccgcgcc gcgcgccgca gcgccccggg atcgcggccc
    13681 gggccgtcgg ccaggccgaa gacgccgagc gacagccgcc cgatggaccc ggcgacctcc
    13741 cggcagtagc cgacgaggtc gtcgtgggac tggtagcgcg cgcccgcgac gtcggcggcg
    13801 catccgtcga tcagctcctc gaacgcctcc agcgggacgg ggaagcgcgc ggcggtgtca
    13861 cgcagggcca ccagcacggc gtcggtgggg tccggccgcg gcgcccgcag ccccgcccgc
    13921 gcctcctcca gcgccgacag ccgctcgtcc accggcccgg ccgcgtcgcc gatgtcgtcg
    13981 atccgccggg cgaaggcgta gagcgcgcag agcgcgcggc gctcgggcgg ggcgagcagg
    14041 cggattccgt aggcgaagtt gcgtgcccgg gtgcgtacga cgcgctcgca gtgccggtag
    14101 gccagcggca gcggtacggg cgccggcgtg cgggccggtc ccgcgccgac ggggcgcagc
    14161 gcggggccgg gcgggcggtc ggggacggga tcaggaatcg cgccgggaac cgtcaccgtt
    14221 cacctccttc agcacgcgtg cccactcgcc gagcaccgcg cggcggcgtg cgcggaccgc
    14281 ccggccgagg acgtcgtgcc gcccgcgctc cagcgccgcg agcgcggccc gcccgcccgc
    14341 gacgtacccg gccaccgcgg tgcgcgcgaa cccgctcagc gtctccagca gcggcatgcc
    14401 ctcgtccagc agcgtggcgg cgcggcgggc ctgcagggcg acggcccggc gcagccgcgg
    14461 ggacgcgtgc ggggcgccga ggtcggcctc gcggcagccg aacctgcgca ggtcctcggc
    14521 ggggaggtag acccggccgc gggcgtggtc ctcacccacg tcctggcagt gctcgatcac
    14581 ctgcagggcc gagcagatgc ggtccgacag ccgcgcccgc tccggcgtgg ccgcgccgaa
    14641 gacgtgcagg acgatccggc cgaccgggtt ggcggacagc tcgcagtagg ccagcagttg
    14701 cgcgaatgtg tcgtagcgcc gcaccacctg gtcgcgccgg ttggcctcca cgaggtggag
    14761 gaagtgcgcc cgcggcacgc cgcgcccggc gaccagcggc gtcagcgccc gcacggcggg
    14821 cagccggggg ctccccccgg cgtagagccg gcccaggtcg gcctccaccg cgttgagcag
    14881 ggcgggccgc tcggcggggt ccgcctcgtc gccgacgtcg tccacgtaac gggcgaagca
    14941 gtacaccgcc atcaggtcga ggcggtacgc gcgcggcagc aggcgggagg ccaccgggaa
    15001 gttctcccgg cgcgcggcgt cgcgtacgtc cgctgcggac atgcctgaag aatctccacc
    15061 gcaattcacc acaaaacccg atagagcggg cgggcgtctt tacgcgcgca acctcccggg
    15121 aaaagcggcg tacaccgccg cgccgctaac ggaaaaagcg gtaaaaacgt ggtcgggaaa
    15181 gacggtggaa gtaagcggcc tttttcccgc ttcttacgct tccggccgtg ggtaaaagct
    15241 tgccgggagc gggagccggt gggcccccgc gccgccgggt acacccacgc cgtgggcgcc
    15301 cagcggtccg acccgcagtc cggcggcgcg gcagcggccg accacgccgg cgagcgcgcc
    15361 cagcgccgaa cgccaggaac cgggggcgga ggtgtggtcg cagtcgtgca gcaacagcgt
    15421 cgccccgccg cgcaggccgg gctccagggt gcgcagcacc gagccgggcg tggcccgtgc
    15481 cgtccagtcc gcgccccagg ccgtccacag caccggccgc aggccgtgcc accgggccgc
    15541 gagcagcgcc tcggcgctca gcacgccgta cggcgggcgg taccacgagg gcggtacgcc
    15601 ggtgacggcg gcgacgaggc gcgcggccct gccgatctcc gcggcgaccc tgcccggccg
    15661 ggcgaccagg gcgttgccgt gccgccagcc gtgcacggcc acctcgtgac cggcccgcgc
    15721 gatgctccgc ccgacctcgg ggtggcgttc gagcagctcg ccgaggagga agaaggtcgc
    15781 ccggcacccg agccggtcca gctcgtcgag gaacagcggg gtagagcgcg gatccggccc
    15841 gtcgtcgaag gtcagcgcca cgtgcccggg atcgccctcg cccgccagag acggcagcag
    15901 gcggcggacc ggaggcagcc aggccgcccc cggtcccgcg tggagcaggg ccagtccggc
    15961 ggcggcgagc gcgtgaggtc gcatcgcctt ccagtgtccg ccacgccgcc ccccaccccg
    16021 gaaggagggc catgagtaac aggacattga tcgtcagcgc ctcgatgggc gcgggccacg
    16081 acgccgtcgc cgccgaactg gcgcgccgcc tgaccgccgc cggggtgcgc gcggagatcg
    16141 tggacgtgct cgccctgctg ccgctgcggc tcggcgcgct gctgcggtgg tggtaccgcg
    16201 tggtgatgct gcgggcgccg tggctgtacg cgctggtcta ccgcgtcttc ttcgtctcac
    16261 gccgggcccc gtccacctcg ccgctgacgg tggtggccgc cgccgggctg gcccgggcgg
    16321 tgcgccgcgt ccgcccctcg ctggtcgtgc cggtcttcca cgtggccgcg caggccgcgg
    16381 ggcacctgcg ggcgcggggg cggctcgcgg cgccgagcgt ggtcgtgctg accgacttcg
    16441 ccgtgcaccg cctctggctg caccccggca acgaccgcta cctgtgcccg gacgcggcca
    16501 cggccctcgc cgtgacggcc gccctcggcc gtccggcctt ccgctgcgcc ccgatcgtcc
    16561 gccccaggtt cgcggcgccc cgggaccgcg ccggcatggc ggacgtccgg acccggatcg
    16621 gcctgcggga cggcgggccg atcgtgctcg tctgcgcggg atcctggggg gtcggccggg
    16681 tcgcggagac cgccgggatc ctggcccggt cgggccggta cgcgcccgtc gtgctgtgcg
    16741 ggcgcaacga gcggctgcgc cgccgtctcg cgcggctgct cggccgcgcc ggagcgggcg
    16801 ccgccctcgg ctggcgtgac gacctggcgg acctgctcgc ctccgcgtac gcgctggtcg
    16861 acaacgcggg cgggctgacc tgcagggagg cgttcgccgc gggggtgccg gtcgtcacgt
    16921 accggcccat cgcgggtcac ggcggggacg gcgtgcgcgc gatggcacgc gccggggtga
    16981 gcgtccacgt gcgccgccgc gcggagctgc tgcgggcgct cgaccggctc cagcccggcc
    17041 tgcccgggcg ggccgcgctc accgcgcggg ccgccgctct gttcagcgct tcgccggccg
    17101 agtcccttct tctcccggac ctcgccgccg cgtcccgatc atgtgagcct gcctcctgag
    17161 cggcgcgtac cgcgacagca gcacgctgcc gtacaggatg agggccatgc ccgtcagctc
    17221 gggcaccacc cacgggcccg tgcggatgtc ctcgccgaac atcgccacgc cgtacgccgt
    17281 gctcgccacg gggtcggtca cggtcagcgc gggctgcacg gcgacgagcg gaccgctgtg
    17341 cagggcgttc tgcagcagga acaggctgca cagcccggcg gccaccatgg cccacagcga
    17401 ccaggagccg gcgagcgtcc gcgcgccggc cggcaactcg tccaccgtgc gcttcatgag
    17461 gacggcggtg taggcgaagc ccagcccggc ggccatcccg agcagcaccg cgcgggcggc
    17521 cccgccgagg gcgatcgcgg cggtcacgca gcaggcgagg agcccgatgg tcacgcccgc
    17581 cgagatcacc caggtcagca ggccgggaag ccggtggccg ggggtgggcg aggccgccgc
    17641 gaggaacccg gccaggccgg ccgtcagtaa gccgacggcc agccaggtct tggggtcgag
    17701 gcggacccgg aacatccagc cggccaccag catcgtgatc ggcagttccg cgacgagcag
    17761 gggctggacg agtgcgagcc ctccgctcgt cagggcgccg gcctgcagca ggaaacccgc
    17821 gatgagcgcg gcgatgccgc ccagccaggt gggccgccgg acgaggtccc agatcaggcc
    17881 gggccggaac gcctcggcgg cgggggcggc gcgggcggcc cggcgctgca gtacggacgc
    17941 gacggcgttg gccgccgcgg cgagcaccgc caggacaaca gcgatcatga ccccccgcgc
    18001 cacgtctcag gcttctcgtc gtcgcgggcc ctctgatcga ggccctgtca gtaccctccc
    18061 cggcgatggc cgccgcatgt cggcgtgaac gctccgaacc ctttttattc ggctataacc
    18121 aaagaaaggc gcgattatta ataaaaatcg agaatgccgg gatttttggg ggtatggccg
    18181 tttgcacaaa cgcacgcagc aggaaaggcg gaaccagaca tggttggacc caccggcctc
    18241 gagcgtcatc ccgacgtcac cgaactgcga cagacctacg atcgggcggg ctcgacggcc
    18301 cccgcccagg tattggaggg gttgtccttc ctggccggcc tttacctggc cctctcgccg
    18361 tggatcgtcg ggttcttcgg actccgcggc ctgaccgtca gcaacctcgt caccggcctc
    18421 gtgatctccg ctctcgctct cgggctcgcg tccgcctacg gccgcacgta cggactgggg
    18481 tggctgctcc cgctgcttgg cgtgtgggcg atcgtctcgc cgtttgtggt gcgcgcggga
    18541 cgtgaggcca cggcgacgac catctggaac aacgtggcga tcggcatcgt gacccttgcg
    18601 ctgggagccg ccgcactggc gatggcacag gcgttccgcc ggcatgagcg gggcgagcgg
    18661 agcgcgcgca gactgggcaa ctggtgacag aagcggcgcc cggcccgcgg caggcgggcc
    18721 gggcgccgtg ctgtcagccc acggggccgg tcgccacctg ggcggtggca accaaggccc
    18781 ggctcgcgcg gggacgcgct cagcgcaggg tgacgctgag acgggccgag gcgtctctga
    18841 ggtagtcgac gaaggcgcgc agggcggggt tggggttggt cgggcggagg gcggcgccga
    18901 cccgccggta gagcttctgc ccctccacct ggcagacctg gatccccgcc gctccctgca
    18961 cgccgaggct cggcacgagg gccacgccga gcccggcccg gaccaggccg agcgtcacct
    19021 cgtagtggtc gctgcggcag cggatggtgg gcgtgaaccc ctccagggcg ctggcccgct
    19081 ccagcaccga caccggggtc tcggtgccga acgtggtgat ccacggctcg tcggccaggt
    19141 cggtcagccg gacgcggggg cggcttccca cggggtggcc gagcggcatg acgagcagct
    19201 gcggctcgtc gaacaggtgg acgacctcga cgcccttcgg cgccttccag gggtccagcg
    19261 cgtgctcgaa cacgaccagc acgtccagct cgccgcgttc cacgtcggtc agcaactcgt
    19321 gcggctgccc gagcaccagg tcgagcacga cgcccggatg gcgggccgtg aaggacgaca
    19381 gcgccatcgg cagcagccgg tagccggccg aggcgaagaa cccgatacgc aactgcccgg
    19441 cgtccgcccg cgcctgcgcg agcaggtcct tctcggcgga ttcgatgagg tcgagcacct
    19501 cctgggcccg cccggccagg cggtgacccg ccgcggtcag ccgcaggctg tgcgcggccc
    19561 gctccaccag cccgaccccc gcctcctcct ccagccgggc gagctggtgg gagacggccg
    19621 agggcgacag ccgcagggac ttggcggctc cggcgatgct cccggtcctg aagacctcca
    19681 ggagcacctt gaggcggtgg ctgctgagca tgcccccagt atcggcgacc tggcatccac
    19741 gctggtcaca gcgggaagcc gagccatcgg ggcggaagga cgctggcggc gacggcgagg
    19801 cccgcctgcc ggatcgcccg gaccagggcg tgctcgcggc ccaccggccc gtgcgcgagc
    19861 acggcgtagc cctcccaccg cgtcccggcc atgacgccca cgtcggcccg ggtgccggcg
    19921 tcggtgccgg tcttgttcgc cacccagacc ccggcggcgt acggcagggc caccggcggg
    19981 tcgcggtcct cgggctcgtg cgggagcagc gcgggcacca gggcgcggtc ggtgttgtgc
    20041 gccatccagc cgagcagcag ccgctgccac ggctcgcggc cgtgcgccag ggaccgcatg
    20101 agcccggcca gctcgcgcgc cgtcccggtg gcgaaggccg gcggatgcac cgggagcctg
    20161 ggctcgcgga tcctgtcgtg gatccgggtc ctggccagtc cgagcgcggc ggcggccgcg
    20221 tccacccggg cgagcccgag ccgccgcagc agcgcgttcg tcgcggtgtt gtcgctgacg
    20281 gaggcggtga gcagcgcgag gtcgccggcc gtccagacgc gggccgagag atcggtcagc
    20341 aggcccgacc cgctcgcgta gtcctcgtcg agcagcggca ccggctcgtc cgggtccacg
    20401 acgccccccg ccacgtcctg ggcgagcgcc gcgagcagca gcaccttgcc ggtgctggcc
    20461 agcggcagca ccacgtcctc gttcacgccg agcaggccgg gaacgcagac ggccagcgtg
    20521 cccggacagg cggccgccgc ctcggccagc cgtgccgccc ccggcacgcc gccggcgtcc
    20581 tttccgctca ccacgtcatt cctttcacag agccagcacc gaacccggac gcgcgccggt
    20641 ctcctcgccg tcgcgcacca ccacctgacc acccgcgacg accacgtcga tcccggcggg
    20701 cggcagcaga ggctcggtga acgtcgccag gtcggccacc gccgcggggt cgaagaccac
    20761 caggtcggcg tgcgcgccgt cgcggatcac cccgcgcccg gtcagcccga aacgggccgc
    20821 ggccatcccg gtcatcttgt gcaccgcctc ctccagtcgc agcagcccca gctcccggac
    20881 gtaccgcccg agcacccggg ggaacgtccc ggcccagcgc gggtgcgggc gcccgcccgg
    20941 cttcggcacg ccgtcggaac cgatcatcgt gtacggcgcg gccagcaccc gccgcacgtc
    21001 ctcctcgacc atcgagtggc tgatgatcgt cacctcgccc gcctcggcca ccagcaggtc
    21061 ggcggccacg tcgaggggat cggcgccggc cgaggccgcg aggtcggcga tggtcctgcc
    21121 ctcggcctga ggatggcggg gcgcgcaggc gaccgagatg cggtcccagc cgccgttgcc
    21181 gaccgtgttc tcccagccgg gcacgccctc cgcgatggcc cggcgcatcc tgtcccgctc
    21241 ggcggggtcg ccgagccgcg ccgtgagcgc ccccaggccg ccgtcgttcg cccagggcgg
    21301 cagcatggcg gccagcgccg tgctgcccgc ggtgtagggg tagacgtcac aggtgatgtc
    21361 catcccctcg gcccgcagcg cggcgatgcg cggcagcgtg cgctcggtgc gtccccaggc
    21421 gtaccggccc gcggtcttgt ggtgcgagac gtgcagcgcc gcgccgctgc gccgggagat
    21481 ctcgatcgcc tcctccagcg cctcctccac gcgcgacatc tcgtcacgca ggtgggtgac
    21541 gtacggcttg ccgtgccggg cggccaccgc ggcgagcgcc acgacctcgt cggtcccggc
    21601 gtacgagccg ggggtgtaga tgaggccggt ggacagcccg gccgcgccct gcgacaggga
    21661 ggcgtcgagc agcgcgcaca tcgcgcgcag ctcatcgggc cgggcgggcc ggtcgaccgg
    21721 gccgagcacg cccgccctga gcgtgccgtg gccgaccagc gaggccaggt ggttggcccg
    21781 gagcacccgc gcgtgcgcgg cggcgaaacc cgcgaagtcg gcgtacatgc cgacgtcgcc
    21841 gccgaaggtg atccgcgcct cggcgcgcat cgccggcagc cgctccggca gggccgggaa
    21901 gaggccggac ccgcagttgc cgcagatctc ggtggtgacg ccctgcagca ccgacgcccg
    21961 caccagcgcc ctgccggagc cgccgccgga cgggccgagc agcgtgacgc cgtcggagtg
    22021 cgtgtgcacg tcgacgaacc cgggggagac gacgcgcccg cgcgcgtcga tcacctccgc
    22081 cgcgccgccc gtgcgggggg cctcgcccgg ggccagcacg gtcagccgcc cggcggccac
    22141 gccgacgtcg gcgggccgcc cggggcggcc cgtgccgtcc accagcaggc caccccggat
    22201 gagcaggtcg aagccggtca ccggacctgc ccgaggaagg tgcgcaaccg ctcgtggcgg
    22261 ggcgcggaga gcacctcgcg cgggtcgccg cgctcgacga tgacgccgtc gtccatgaac
    22321 acgagctggt cgccgacctc ccgggcgaag ttcatctcgt gggtgacgac catcatggtc
    22381 atgccggtcg ccgcgaggtc ccgcatgacg gccagcacct cctgcaccag ctcggggtcg
    22441 agcgcgctgg tcggctcgtc gaacagcatc aggctgggcc gcatcgcgag gctgcgggcg
    22501 atggccaccc gctgctgctg gccgccggac agctgggccg ggtagtggtg ggcgcggtcg
    22561 gccaggccga cccgctcgag cagctcctcc gcctgccgtc tggcctgggc ggcgcgcgtg
    22621 cccagcacgg tgaccggccc ctccatgacg ttctcgatcg cggtgcggtg cgggaacagg
    22681 tggaagcgct ggaacaccat gccgatgccg cgccgctgcc gggacagctc ggccgggcgc
    22741 agcgcgtgca gccggccgcc gcgctcggcg tagcccatca gctcgccgtt cacccagatc
    22801 cggcccgagt cgatcgtctc caggcggttg acgcagcgca gcagggtcga cttgcccgac
    22861 cccgacgggc cgacgatgca caccacctcg ccggcgggga cgtcgaggtc gatgcccttg
    22921 agcacctcca gagcgccgaa ccgcttgcgg accgcgcgga tgcgcaccat cggctggtca
    22981 gggccgctca tgagggctcc ttctgcaggg gccgcaggtt gcggcggacc cgggaggaca
    23041 gccgcacgtg gccgcgttcg aaccgcttct ccacgaagtg ctggccgacg ctcgcgatcg
    23101 tggtgagcac gacgtaccag atcgaggcga ccacgagcat cgcgatgacc tcgaagttgc
    23161 cgaggtagat gcgctgcgcc acggtcagca gctcggctcc ggcgatcacc gagaccatcg
    23221 aggtggtctt cagcatcgag atgaactggt tgccggtcgg cgggatgatc acccgcatgg
    23281 cctgcggcag caccacgcgg cgcagcacct gccggtgcga catgccgagc gactcggccg
    23341 cctcccgctg gccggggtcg accgagcgga tacccgcgcg gacgatctcc gccatgtacg
    23401 cgccctcgtt gatggccagg ccgagcaacg ccgcggtgaa cggcgtgatg acctcgttgg
    23461 cctgccattc gatcagcttg ggcccgccga acgggacgcc gatcgcgaag gcggggaaga
    23521 ccagcccgat gttgaaccag aagatgagct gcaccagcag cggcgtgccg cggaagaacc
    23581 acgtgtagag cgcggaggtg ccgcgcagcg cggggttgtc cgacagctgc atgacggcgg
    23641 cgagcacccc aagcaccagg ccgatggcca tggacagcac ggtgagctgg atcgtgaccc
    23701 acagaccgcc gaggatcctg ccgtcggcca ggtaggcgac gatgacgtcc cagtgcaggt
    23761 tctcgttgac gatgaccgtg taggccagcc agaccaggaa gaggagggcg gcggccgccc
    23821 cgagccaccg gccgggccgt acgggacgca cggcctcgat cggcagctcg gcggcggcct
    23881 cctgctcccg ggtcacttcc acggctgggt gttgaccagc acgccgtcga cggcgttggc
    23941 cgccacgccg tactcgtcga gcacggcctt gtagccgccg tcggcctgga gctcctccat
    24001 cgccttggcg accgcgtcgc gcagcgccgt cttgcgcttg tcgacggcga tgccccacgg
    24061 cccggcgtcg tactgctcgg gcagcacgtc gtacttgccg gtgtccttgg cgtacatgac
    24121 ggcgacgggg tagtccacga tcgtggccac ggcgcgcccg gagtcgatcg agagcaggcc
    24181 ggtgggcgcg tcctcgctct gcatgatctt catcttcgtg gcgcacttct cgttctgctt
    24241 ctcgccgatg gcgaggttgg agctgccctt ggccagcacc accgtgcggc cgcacaggtc
    24301 ctcgaggttc ttgatgccgt cggggttgcc cttcttcacc atgatggcgc cgcccgcgtt
    24361 gaagtagtcg acgaagtcga ccgccgcgcg ccgctcctcg gtgtcgctca tcgaggacat
    24421 cacgatgtcc cagcgcccgc cctgcaggcc ggggatgagc ccgtcgaagg ccgcgttggt
    24481 gatcgagaac ttcagcccga gcttggccgc gatggccgcg ccgagatcgg ggtcgacacc
    24541 ggtgagctcc tgggtgccct tcttgtacat ctccatcggg gggtagccct cggacgtggc
    24601 gacccgcagc gtgcccgtct tgcgcacgtc ctcggggacc aggtccttgg cggtcttgcc
    24661 cgtcgtcgcc gccgcgttct cgcccgcggc ggttccggac gacgaacgcc cgcagccgcc
    24721 ggcgagcgcc gacacgacca gcgcgccgac tatggccaca tataggcgct ttgtcatgga
    24781 acctcctgtt ttgcgaacga ttgagcttat gctggcgaca ggaggtatcg gccgtaacac
    24841 tcgtgaacgc ttgcgcttct gagcatcgaa gatttcgatg ctcgcgcgcc tcagcctccg
    24901 gcctcgtgcg ccgggcggga ggcggacgcc gcgggccgta cgaccgcgac ccgggcacgc
    24961 tgaacgccgt gcttgccagc cgggcgcgcc attgcggtcc agcacaccgc gcccgcggcg
    25021 agagccgcca ccagcgtgag cc
//
