LOCUS       NZ_JABBXA010000012     10900 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H13382 NODE_12, whole genome shotgun sequence.
ACCESSION   NZ_JABBXA010000012
VERSION     NZ_JABBXA010000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H13382
  ORGANISM  Microbispora sp. H13382
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 257541)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 257541)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Antibiotics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014161445.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 07:22:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,906
            Genes (coding)                    :: 7,786
            CDSs (with protein)               :: 7,786
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 21 of 121
            Pseudo Genes (incomplete)         :: 104 of 121
            Pseudo Genes (internal stop)      :: 8 of 121
            Pseudo Genes (multiple problems)  :: 11 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:45:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 207654
            Orig. end                         :: 218554
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBXA010000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10900
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10900
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10900
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5900](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5900)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            135..1580
                     /locus_tag="HHX41_RS24060"
     CDS             135..1580
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133318.1"
                     /locus_tag="HHX41_RS24060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_182907809.1"
                     /transl_table=11
                     /translation="MTWVPTGLRARLVITFLLVAITASAMVAGLGYQIVRRGLLERAER
                     GAVADVRETLSRITLPIGASEVVWPSDTTVTDEDLDGVVRALEAPERTVIVTYGDHRRA
                     NTGAQFTMTDVPDQLRWQAARRLVYQRVLFRDRAWLIVATQIQRANRDGVLRPTGLTAY
                     VFVPLSDEEAVLTRLRTALAQAGGITLVLALTLALLSARRVLLPVRRLGAAARALGAGE
                     LHVRLPVRGRDELAELTATFNETAAALEDTVSELRTLESTSRRFVADVSHELRTPLTAM
                     TAVTDMLSEDAEDLPDDAGEAVRIVVREIDRLRVLVEHLIEISRFDAGAATLRRETVDV
                     GDTLADCLEVRGWADRVKLTVPVGLTFSLDARRFDVMVANLVGNALNHGAPPVVVSARV
                     AVGGKTHGWLEVTVRDHGSGIPEQVLPLVFDRFYKAGTDRARSAGSGLGLAIAKANAEL
                     HGGSITAERCEPGTLFLLRIPKP"
     gene            1577..2137
                     /locus_tag="HHX41_RS24065"
     CDS             1577..2137
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS24065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_182907810.1"
                     /transl_table=11
                     /translation="MKAPRLRTALAALLAGLLVAPAAACGVAPTGVTDAGPAPVISGTP
                     TLVTIYLLRNGRLAPTRVAARSPHVNDVLDALFKASGRSSNRLSTALTGLTPTQVQLVR
                     YAPDAGSRNDPDNTLSLRVRLFVTGWKITRTAMAQITCTARLRPEIWAVEIAHATPGRN
                     GPLKTHTCQEFWDLAPKDGHLPP"
     gene            complement(2145..3455)
                     /locus_tag="HHX41_RS24070"
     CDS             complement(2145..3455)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133320.1"
                     /locus_tag="HHX41_RS24070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PhoH family protein"
                     /protein_id="WP_169983413.1"
                     /transl_table=11
                     /translation="MAVSSSNPSTSRTYVLDTSVLLADPAAMSRFAEHEVVVPIVVITE
                     LEAKRHHPELGYFAREALRFLDDLRVRYGRLDEPMPIGDGTIRVELNHSDPSCLPAGFR
                     LGDNDTRILTVAQNLAVEGKDVVLVSKDLPMRVKAASIGLSAEEYRAGMVVESGWTGMA
                     ELQVTTEEMDALFESGTADIDEARDLPCHTGLRLLSSRGSALGRVLPDKSVRLVRGDRE
                     VFGLHGRSAEQRIALDLLMDPDVGIVSMGGRAGTGKSALALCAGLEAVLERRQHRKIIV
                     FRPLYAVGGQELGYLPGTENDKMGPWAQAVYDTLGAVTSPEVIEEVIDRGMLEVLPLTH
                     IRGRSLHDAFVIVDEAQSLERGVLLTVLSRIGANSRVVLTHDIAQRDNLRVGRHDGVVA
                     VVEKLKGHPLFAHITLTRSERSPIAALVTEMLEDITL"
     misc_feature    complement(3409..3422)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.88"
                     /tool="antismash"
     gene            complement(3702..4463)
                     /locus_tag="HHX41_RS24075"
     CDS             complement(3702..4463)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894896.1"
                     /locus_tag="HHX41_RS24075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isoprenyl transferase"
                     /protein_id="WP_169983414.1"
                     /transl_table=11
                     /translation="MSVRDLVYKLYERRLERKLSSDQIPRHVGVIVDGNRRWARAMGLR
                     DVSRGHQKGADKISELVAWCREAGVEYVTLWLLSTDNLTRDKAELEPLLQVIENLVQDL
                     VDQGWHLNPMGSLDLLPDHTARVLKHAKETTSHRPGLIVNVAVGYGGRREIADAVRSLL
                     QEHASKGASIEDLVEVLDVEHIAEHLYTRGLPDPDLVIRTSGEQRLSGFLLWQSAHSEF
                     YFCEAYWPDFRRVDFLRALRSYAARHRRYGS"
     gene            complement(4691..5008)
                     /locus_tag="HHX41_RS39785"
     CDS             complement(4691..5008)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS39785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_220504365.1"
                     /transl_table=11
                     /translation="MPEPAAPRNARAALAAAQAELVAALVAGGRVPDGFDPGRLAVQAR
                     GLLAKRCGSVARAAPDLAEALGAEFAGLFAAYAAGNVKPEGGPRADARDFTAWMRARGR
                     P"
     gene            complement(5001..5900)
                     /locus_tag="HHX41_RS24080"
     CDS             complement(5001..5900)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545141.1"
                     /locus_tag="HHX41_RS24080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_310742146.1"
                     /sec_met_domain="DUF692 (E-value: 3.8e-80, bitscore: 262.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAERRFGRWLPSGRPAGGHKRHAAGAGQNAGRSAGLGVGIGWRPE
                     IDLTVERLPGVGFVEVIAENVDPARPPESLTVLRAAGVPVVPHGVGLGVGGADRPDPAR
                     LARLAACAEALDAPLVSEHVAFVRAGGVEAGHLLPVPRTREALSVIVENVREAQDALPV
                     PLALENVAALFGWPDDELTEARFLGELVERTGVRLLVDVANLYTNQVNLGLDARRALDA
                     LPLEAVAYVHVAGGHAHDGLWHDTHTASPPAEVLDLLTELCGRVTPPGVLLEWDDAYPG
                     DGVLAGELGRIREAMSRA"
     gene            complement(5893..6864)
                     /locus_tag="HHX41_RS24085"
     CDS             complement(5893..6864)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="HHX41_RS24085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_182907811.1"
                     /transl_table=11
                     /translation="MELVLVVAAAILAALIVTTALAVGRERREARLASGARPGSGLDAY
                     ELAYLAGGPPQVVNTALASLAVGEQVRVARGGRVTAVAGAPATSADPVEQAVLDLATRA
                     GGASAAEVRRRAGDGSAMAALKERLLAQGYLLPEGSLEGARRLNARLRALAVLALAAAS
                     VTLVLILFIGTVAATAADWVTAGIAAVSGGCALIASLTYAASLRNPLSPAGEEALRQAR
                     ERHPRGVFAHGTAGALGVGGAAGLAAVTPIALYGLGELGDPHLAAQIATDEVLMRRPVD
                     GGPSGGDGGGFVGCASSGCGSGGSHSCGGGCGGGCGGGCGGG"
     misc_feature    complement(6904..6918)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.07"
                     /tool="antismash"
     gene            complement(7001..8797)
                     /locus_tag="HHX41_RS24090"
     CDS             complement(7001..8797)
                     /EC_number="4.1.1.32"
                     /GO_function="GO:0004611 - phosphoenolpyruvate
                     carboxykinase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0017076 - purine nucleotide binding
                     [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133322.1"
                     /locus_tag="HHX41_RS24090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoenolpyruvate carboxykinase (GTP)"
                     /protein_id="WP_182907812.1"
                     /transl_table=11
                     /translation="MSISVEVPTPTTHSDLAAWVSQIAELTQPDRIEWCDGSEAEWTRL
                     TNLLVEQGTFKRLVKRPNSFYAASDPSDVARVEDRTFICSEREEDAGPTNNWIAPDEMR
                     RTFATLFKGCMRGRTMYVVPFCMGPLGGNISQLGVEITDSPYVVVSMRIMTRMGEEALR
                     LIEERGDFVKAVHSVGAPLEHGQADVPWPCSKTKYISHFPETREIWSYGSGYGGNALLG
                     KKCYALRIASVMARDEGWLAEHMLILKLTPPQGEARYVAAAFPSACGKTNLAMLQPTIP
                     GWKVETIGDDIAWMRFGPDGRLYAINPEAGFFGVAPGTGQSTNANAIETLWGNSIFTNV
                     ALTDDGDVWWEGLTDEPPAHLVDWKGRDWTPDSPEPAAHPNARFTTPAEQCPTIAREWQ
                     DPAGVPISAILFGGRRATAVPLVTESLSWQHGVFLGANVASEKTAAAEGKVGELRRDPF
                     AMLPFCGYNMGDYFAHWVEVGTMTDPEKLPKIYYVNWFRKDANGRFLWPGFGENSRVLK
                     WIVDRLNGVADAVPTPIGNLPASLDTEGLDLAPEDMELLLSVDPEVWREEAALIPSHFE
                     TFGDHMPKELWDEYRALVQRLG"
     misc_feature    8861..8876
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.76"
                     /tool="antismash"
     misc_feature    8877..8894
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.96"
                     /tool="antismash"
     misc_feature    9032..9047
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.22"
                     /tool="antismash"
     misc_feature    9051..9066
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.25"
                     /tool="antismash"
     misc_feature    complement(9073..9088)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.34"
                     /tool="antismash"
     gene            complement(9079..9597)
                     /locus_tag="HHX41_RS24095"
     CDS             complement(9079..9597)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894902.1"
                     /locus_tag="HHX41_RS24095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_182907813.1"
                     /transl_table=11
                     /translation="MNADEQLSAWFAGRLPENWFTGTPEVVVDREEISVLGTLPPLSVV
                     EGLPDPERAAAVEGYVERFREETRERRIDIAREAEHRFRRKVSWGVVVGDETVMFTTLS
                     VPVMTRLRQPERQVLDTLVAAGVARSRSDALAWCVRLVGKHTDSWLADLRDALQHVDRI
                     RAEGPGGLD"
     misc_feature    9597..9610
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.79"
                     /tool="antismash"
     misc_feature    complement(9599..9612)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.73"
                     /tool="antismash"
     misc_feature    9649..9658
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.37"
                     /tool="antismash"
     misc_feature    9654..9669
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    9656..9670
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.12"
                     /tool="antismash"
     misc_feature    9657..9670
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.45"
                     /tool="antismash"
     misc_feature    complement(9657..9672)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.21"
                     /tool="antismash"
ORIGIN
        1 gaccacacgc acgtggcgga ctcccgcctg gtcgacgcgt gtgtgcagcg catccgcgcc
       61 aagatcgagc cggtgcccgc cgaccccgtc tacatccaca ccgtgcgcgg cttcgggtac
      121 cgcttcagcc cgccatgacc tgggtgccca ccgggttgcg ggcccggctg gtgatcacct
      181 tcctgctggt ggcgatcacg gcgtccgcca tggtcgcggg gctgggatac cagatcgtcc
      241 gccgggggct gctggagcgc gcggagcggg gcgcggtcgc cgacgtgcgc gagacgctct
      301 ccaggatcac gctgccgatc ggcgcgagcg aggtggtctg gccgagcgac accaccgtca
      361 ccgacgagga cctcgacgga gtggtgcggg cgctggaggc ccccgagcgg accgtcatcg
      421 tgacctacgg ggaccaccgg cgcgccaaca ccggggccca gttcaccatg accgacgtgc
      481 ccgaccagct ccgctggcag gcggcgcggc ggctggtcta ccagagggtg ctgttcaggg
      541 accgggcctg gctgatcgtc gccacgcaga tccagcgggc caaccgcgac ggtgtgctac
      601 gcccgacggg cctgaccgcc tatgtcttcg tgcctctgtc ggacgaggag gccgtgctta
      661 cccgcctcag gaccgcactc gcgcaggccg gaggcatcac gctcgtcctg gcgctgaccc
      721 tggccctgct gtcggcccgg cgggtgctgc tgcccgtacg gcggctgggc gcggccgccc
      781 gcgcgctcgg cgcgggggaa ctgcacgtcc gcctccccgt acggggcagg gacgagctgg
      841 ccgagctgac cgcgacgttc aacgagacgg cggcggcgct ggaggacacg gtctccgagc
      901 tgcggacgct ggagtcgacg tcgcggcggt tcgtcgcgga cgtctcccac gagctgcgca
      961 cgccgctgac cgcgatgacc gcggtgacgg acatgctgtc ggaggacgcc gaggacctgc
     1021 cggacgacgc cggggaggcc gtgcggatcg tcgtccgcga gatcgacagg ctccgggtgc
     1081 tggtcgagca cctcatcgag atcagcaggt tcgacgcggg cgccgccacg ctccgccggg
     1141 agaccgtcga cgtgggcgac acgctggccg actgcctgga ggtgcggggc tgggccgacc
     1201 gggtgaagct caccgtgccc gtcgggctca cgttctccct ggacgcccgg aggttcgacg
     1261 tgatggtggc caatctcgtc ggcaacgcgc tgaaccacgg cgcgccgccc gtcgtggtga
     1321 gcgcgcgggt cgcggtcggc ggcaagaccc acgggtggct ggaggtgacc gtgcgcgacc
     1381 acgggagcgg catccccgaa caggtcctcc ccctcgtctt cgaccgcttc tacaaggcgg
     1441 gcaccgaccg ggccaggagc gcgggcagcg gcctcggcct ggccatcgcc aaggccaacg
     1501 cggagctgca cggcggctcg atcacggccg agcggtgcga gcccggcacc ctcttcctgc
     1561 tgcggattcc caagccatga aagcgccgag gctcagaacg gcgctggcgg ccctgctcgc
     1621 ggggctcctc gtggcgccgg cggcggcctg cggggtcgcg ccgaccgggg tgaccgacgc
     1681 cggtcccgcg ccggtcatca gcggcacccc caccctcgtc acgatctacc tgctgcggaa
     1741 cggccgcttg gcgccgacgc gggtcgcggc ccggtcgccg cacgtcaacg acgtgctcga
     1801 cgccctgttc aaggccagtg gacggtcgtc gaaccggctg tccacggcgc tgaccgggct
     1861 cacgccgacg caggtgcagc tcgtcaggta cgccccggac gcgggcagcc gcaacgaccc
     1921 cgacaacacc ctcagcctgc gggtgcggct gttcgtgacc ggctggaaga tcaccaggac
     1981 cgccatggct cagatcacct gcacggcgcg gctgcgtccc gagatctggg ccgtggaaat
     2041 cgctcacgcg actcctggca ggaacgggcc cctcaagacc cacacctgcc aggagttctg
     2101 ggatctggcc ccgaaggacg gccatctccc gccgtgaggg agttctagag cgtgatgtcc
     2161 tccagcatct cggtcaccag ggcggcgatc ggcgaccgct cggacctggt cagcgtgatg
     2221 tgggcgaaca gcgggtggcc cttgagcttc tccaccaccg cgacgacgcc gtcgtgccgg
     2281 cccacccgca ggttgtcccg ctgggcgatg tcgtgggtga gcacgacccg cgagttggcc
     2341 ccgatgcggg acaggaccgt cagcagcacg ccgcgctcca gcgactgcgc ctcgtccacg
     2401 atcacgaacg cgtcgtggag ggaacggccg cggatgtggg tcagcgggag gacctccagc
     2461 atgccgcggt cgatgacctc ctcgatgacc tcgggagacg tcaccgcgcc cagcgtgtcg
     2521 tagaccgcct gggcccaggg gcccatcttg tcgttctccg tgccgggcag gtagcccagc
     2581 tcctggccgc ccacggcgta caggggccgg aacacgatga tcttgcggtg ctggcggcgc
     2641 tccagcaccg cctccaggcc cgcgcacagc gccagcgcgg acttgccggt gcccgcccgg
     2701 ccgcccatcg agacgatgcc gacgtcgggg tccatgagca ggtcgagcgc gatgcgctgc
     2761 tcggcggacc ggccgtgcag cccgaagacc tcccggtcgc cccggaccag ccgtaccgac
     2821 ttgtccggca ggacgcggcc gagcgccgag ccgcggctcg acagcagccg caggccggtg
     2881 tgacacggca ggtcgcgcgc ctcgtcgatg tcggccgtgc cggactcgaa gagggcgtcc
     2941 atctcctccg tggtgacctg gagctccgcc ataccggtcc agccggactc gaccaccatg
     3001 ccggcgcggt actcctccgc gctgaggccg atggacgcgg ccttgacccg catcggcagg
     3061 tccttcgaca ccagcaccac gtccttgccc tccaccgcca ggttctgggc gacggtgagg
     3121 atgcgggtgt cgttgtcgcc caggcggaag cccgccggga gacaggatgg atcactatgg
     3181 ttcagctcga cccggatggt cccgtcgccg atcggcatgg gctcatccag ccgtccgtac
     3241 cgcactctga ggtcatcgag gaagcgcagc gcctccctgg cgaagtagcc cagctcgggg
     3301 tggtggcgct tggcctccag ttccgtgatg acgacgatcg gaacgacgac ctcgtgctcg
     3361 gcgaagcggc tcatcgccgc cgggtcggcg agcaggacgg acgtgtccag aacgtaggtg
     3421 cgggatgtgg acgggttgct cgaggacact gccacgcgtt ctcccccggg cgcctgaggt
     3481 gggcgccctg ccttgactgg tggtgaacgg accgggcccg tgacctgcga gggcagaccg
     3541 gggctccggc cctccccgca tggtggtcgc gcaaggacgg gccctctccc gaggtgatgg
     3601 ccgccgatct cctcgacggc cgctcagcta ccacggtacg taacgaatct cccgggccca
     3661 ataggtctgc gccgtttgga agatgctggt cacgtaccgt ctcaggagcc gtaccgacgg
     3721 tgtcgtgcgg cgtacgagcg gagcgcccgc aggaagtcga ctctgcggaa gtcgggccag
     3781 taggcctcgc agaagtagaa ctcggagtgg gcgctctgcc agagcaggaa tccggagagt
     3841 cgctgctctc ccgaggtccg gatgacgaga tccgggtcgg gcaggccgcg cgtgtagaga
     3901 tgctccgcga tgtgctcgac gtcgaggacc tcgacgaggt cctcgatgct cgcgcccttg
     3961 ctggcatgct cctggaggag ggagcgcacc gcatcagcga tctcacgcct tcctccatac
     4021 ccaacggcaa cgttcacaat caggcctgga cgatgcgatg tggtttcttt tgcgtgtttg
     4081 aggacacgag ccgtgtgatc gggcagaagg tcgagcgagc ccatggggtt gaggtgccat
     4141 ccctggtcca cgagatcctg cacgaggttc tcgatcacct ggagcagcgg ctccagctcg
     4201 gccttgtccc tggtgaggtt gtcggtggag agcagccaca gcgtcacgta ctcgacgccg
     4261 gcctcgcggc accacgcgac cagctcggag atcttgtcgg cgcccttctg atggccccgg
     4321 ctgacgtccc gcaaccccat ggcccgcgcc caccggcggt tgccgtccac tatgacgccg
     4381 acatggcggg gaatctggtc ggaggacagc ttccgttcga gcctgcgctc gtacagcttg
     4441 tacacgagat cgcgcacgct catgccacct cctcgcctgt cggctcggag ttcggtcgtg
     4501 ccggaggcgc gcaggtcagc acttcgcgaa acgcgctgtg tttatcgatt cgctcgctgc
     4561 gctcgctcat gcaaccctct tcctcgcgac cggtggggct cgatcaccaa ttatcgcggg
     4621 cgaaccggca tgccctgccc tctcctcaga ggctttcctg ggcacggccg gagtaacccg
     4681 cgccgcgtgg tcaggggcgt ccgcgggccc gcatccaggc ggtgaagtcc cgcgcgtccg
     4741 ccctcggccc gccctcgggc ttcacgtttc cggcggcgta cgcggcgaac agaccggcga
     4801 actcggcgcc gagtgcctcg gcgaggtcag gggcggcgcg ggcgaccgag ccgcaccgtt
     4861 tggccagcag cccgcgggcc tggacggcca gcctgccggg atcgaagccg tccggcacgc
     4921 gtccgcccgc gaccagggcc gccaccagct ccgcctgggc ggcggccagc gcggcccgcg
     4981 cgttccgggg agccgccggc tcaggcacgg gacatcgcct cccggatccg gcccagctcg
     5041 cccgccagga cgccgtcgcc gggataggcg tcgtcccact ccagcagtac gcccggcggc
     5101 gtcacccggc cgcacagctc ggtcagcagg tcgagcacct cggcgggagg ggaggcggtg
     5161 tgcgtgtcgt gccagaggcc gtcgtgagcg tgcccgcccg ccacgtgcac gtacgcgacg
     5221 gcctccagcg gcagcgcgtc gagcgcccgc cgcgcgtcca gaccgagatt gacctggttc
     5281 gtgtagaggt tggccacgtc gaccagcagc cgcacgcccg tacgctcgac cagttcgccg
     5341 agaaaccgcg cctcggtcag ttcgtcgtcc ggccagccga acagggccgc cacgttctcg
     5401 agcgcgagcg gcacgggaag cgcgtcctgc gcctcccgca cgttctccac gatcaccgac
     5461 agggcctccc gggtgcgcgg gaccggcagc aggtggccgg cctccacgcc cccggcccgc
     5521 acgaaggcca cgtgctcgct cacgagaggc gcgtccaacg cctcggcaca cgccgcgagg
     5581 cgcgccagcc gggccggatc gggacggtcc gccccgccga cacccaggcc cacgccgtgg
     5641 ggcacaacgg gcaccccggc ggcgcgcagc acggtcaggg actcgggcgg ccgggccgga
     5701 tcgacgttct cggcgatcac ttcgacgaac ccgacgccgg gcagccgctc caccgtgaga
     5761 tcgatctccg gccgccagcc gatgccgacg ccgagaccgg cacttcgacc ggcattctgg
     5821 ccggcaccgg cggcgtgcct cttgtgcccc ccggcaggcc tgccggacgg cagccacctc
     5881 ccgaaccggc gctcagccac cgccgcaacc gcctccacag ccgccgccgc aaccccctcc
     5941 gcaggaatgc gagccgccgg agccgcatcc gctcgacgcg cagcccacga acccgccgcc
     6001 gtcaccgccc gagggcccac cgtcgacggg acggcgcatg aggacctcgt cggtcgcgat
     6061 ctgggccgcg aggtgcgggt cgccgagctc gcccaggccg tacagggcga tgggcgtcac
     6121 cgcggcgaga cccgccgcgc cgcccacgcc gagcgccccg gcggttccgt gcgcgaagac
     6181 gcccctcgga tgcctttcgc gcgcctgccg cagcgcctcc tcgcccgccg ggctcagcgg
     6241 gttccgcagg gacgcggcgt acgtgaggga ggcgatcagt gcgcagccgc cggagaccgc
     6301 ggcgatcccg gccgtgaccc agtcggccgc ggtggcggcg acggtcccga tgaagaggat
     6361 cagcacgagc gtgacggagg cggcggcgag ggcgagcacc gcgagtgcgc gcaggcgtgc
     6421 gttgaggcgg cgcgcgccct ccagagagcc ctcgggcagc aggtagccct gcgcgagcag
     6481 gcgttccttc agcgccgcca tcgcggagcc gtcgcccgcg cggcgcctga cctcggccgc
     6541 gctcgccccg ccggcccgcg tggccaggtc gaggacggcc tgctcgacgg gatcggcgga
     6601 ggtggcgggg gcgccggcga cggcggtgac cctgccgccg cgcgcgaccc gcacctgctc
     6661 accgacggcc agcgaggcga gcgccgtgtt gaccacctgc ggcggcccgc ccgcgagata
     6721 ggccagttcg taggcgtcga ggccggaccc tggccgcgct ccggacgcga gccttgcttc
     6781 gcgccgctcc cggccgacgg cgagagcggt cgtgacgatg agtgccgcga gaatcgccgc
     6841 ggcgacgacg agcaccagtt ccatgtgcgc cctcctccgg gggagaagag ggggaccccg
     6901 aaccgggccg gacggcccgc gccccgtcta tccgctagac gaacctccca cggggagagt
     6961 tccgtgccgg gacgacggcg cgcgggccgt ggtcgaggac tcagccgagc cgctggacca
     7021 gggcgcggta ttcgtcccac agctccttcg gcatgtggtc gccgaaggtc tcgaagtggg
     7081 acgggatcag cgcggcctcc tcgcgccaca cctcgggatc gacgctgagc agaagctcca
     7141 tgtcctcggg cgcgaggtcg aggccctcgg tgtcgagcga ggccggcagg ttgccgatcg
     7201 gcgtgggcac ggcgtcggcc acgccgttca gccggtcgac gatccacttg agcacccggc
     7261 tgttctcgcc gaagcccggc cacaggaagc ggccgttcgc gtccttgcgg aaccagttca
     7321 cgtagtagat cttcggcagc ttctccgggt cggtcatcgt gccgacctcg acccagtgcg
     7381 cgaagtagtc gcccatgttg tagccgcaga acggcagcat cgcgaacggg tcgcggcgca
     7441 gctcgccgac cttgccctcg gcggcggccg tcttctccga ggccacgttg gcgcccagga
     7501 agacgccgtg ctgccagctc agcgactcgg tcaccagcgg cacggcggtc gcccggcggc
     7561 cgccgaacag gatggccgag atcggcaccc cggccgggtc ctgccactcg cgggcgatcg
     7621 tcgggcactg ctcggccgga gtggtgaacc gggcgttcgg gtgggcggcg ggctccgggg
     7681 agtccggcgt ccagtcgcgg cccttccagt cgacgaggtg cgccggcggc tcgtcggtga
     7741 ggccctccca ccagacgtcg ccgtcgtcgg tcagcgcgac gttggtgaag atgctgttgc
     7801 cccacagcgt ctcgatcgcg ttggcgttcg tggactggcc ggtcccgggc gcgacgccga
     7861 agaagccggc ctccgggttg atcgcgtaga gcctgccgtc ggggccgaag cgcatccagg
     7921 cgatgtcgtc gccgatcgtc tcgaccttcc agcccgggat cgtgggctgg agcatggcga
     7981 ggttcgtctt gccgcacgcc gacgggaagg ccgccgcgac gtaccgcgcc tcgccctgcg
     8041 gcggcgtgag cttgaggatc agcatgtgct cggccagcca gccctcgtcg cgggccatca
     8101 cgctggcgat gcgcagtgcg tagcacttct tgcccagcag cgcgttgccg ccgtagcccg
     8161 agccgtacga ccagatctca cgggtctccg ggaagtggct gatgtacttg gtcttgctgc
     8221 agggccacgg cacgtcggcc tggccgtgtt ccagcggcgc gcccaccgag tggaccgcct
     8281 tgacgaagtc gccgcgttcc tcgatcaggc gcagcgcctc ttcccccatg cgggtcatga
     8341 tccgcatcga cacgacgacg tacggcgagt cggtgatctc gaccccgagc tgcgagatgt
     8401 tcccgcccag gggacccatg cagaacggca cgacgtacat cgtccggccc cgcatgcagc
     8461 ccttgaacag cgtggcgaac gtccggcgca tctcgtcggg cgcgatccag ttgttggtgg
     8521 ggccggcgtc ctcctcgcgc tcggagcaga tgaacgtccg gtcctccacc cgggcgacgt
     8581 cgctcgggtc cgaggcggcg tagaagctgt tgggacgctt gaccagccgc ttgaaggtgc
     8641 cctgctccac cagcaggttg gtcaggcgcg tccactcggc ctcggagccg tcgcaccatt
     8701 cgatccggtc cggctgggtc agctccgcga tctggctcac ccaggccgcc agatcgctgt
     8761 gcgtggtggg cgtcggtacc tctactgaaa tggacacggg ggcggctcct taatctctca
     8821 gggccagagc atcatgagcg atgaatggcc tccgaatcca attggagtag accaccgtgt
     8881 ttccactccg ttaaatcggc gccattcttg gcttcacgac ctccaacagc gtcgccgcag
     8941 gcagtggtcg tgatgtcgtg ggaccttacc cactccggcc ctgttggaaa aaacgtcctt
     9001 ctccccctta cccgcctcgc cggcgttaca cattggtata ggccaattca attggtccag
     9061 accactgggc gaattggttc agtccaatcc gccgggccct tccgccctga tccggtccac
     9121 gtgctggagg gcatcgcgca ggtcagcgag ccaactgtcg gtgtgtttgc cgacgagccg
     9181 gacgcaccag gccagggcgt cgctgcggct gcgcgcgaca cccgcggcga ccagtgtgtc
     9241 gaggacctgc cgttcgggct gccgcagccg ggtcatgacc gggacgctga gagtggtgaa
     9301 catcaccgtc tcatcgccca cgacgacgcc ccaggagacc ttgcggcgga agcggtgctc
     9361 ggcctccctc gcgatgtcga tcctgcgctc gcgggtctcc tcgcggaagc gttcgacata
     9421 tccctcgacg gccgccgcac gctccgggtc ggggagccct tcgaccaccg acagcggcgg
     9481 gagcgtgccc agcacgctga tctcctcgcg gtcgacgacg acctcggggg tcccggtgaa
     9541 ccagttctcg ggcaaccggc ccgcgaacca ggcactcagc tgttcgtctg cattcatgta
     9601 atcaacatta catcgctacc cacagcggaa gccgaggttg acagtagcta ctttttgaga
     9661 gttactttca aattatggct tctcccactt cccgctggtg ggcgctcggc gccctcgtgc
     9721 tgagcgccct cgtcatcggc atggacgcga cggtgctcaa cgtggcgctg cctacgctcg
     9781 cggccgacct gcacgcctcg accggcgacc tgcagtggat cgtcgacgcg tacctgattc
     9841 cgttcgccgc gctcatgctc ccggcgggcg cgctcggcga ccgcttcggc cgcaggcgcc
     9901 tgctattggc cgggctcgcg gccttcggga tcgcgtcggt gctcgcgacg tacgcgggcg
     9961 gcatcggcgc cctgatcgcg gcccgcgcgc tgatgggcgc cggcggcgcg gtgatcatgc
    10021 cgctgtcgac ctcgatcctg ccggtggtct tccctccggc cgagcgtggg cgcgcgatcg
    10081 ccgtgtggac ggccgccatg gcgctcggcc tgcccctcgg ccccgtcgtg ggcggctacc
    10141 tgctcgacca cttctggtgg ggctcggtct tcctcgtgaa catccccatg atcgtcgtcg
    10201 cggcggtggc ggtggccgtg ttcctccccg agtcgcgtga ccccgccgcg ccgcggaccg
    10261 acgtgcccgg cgcgctgctg tcggtgacgg gcctggccgc gctggtgtac ggcgtcatcg
    10321 aggctccggc gcgcggctgg ggccaccccg ccgtgctggg cggtctcggc accggggcgg
    10381 cgctgctggc ggtgttcgtc cgcgtcgagg cccgcacccg gcagccgatg atggacctcg
    10441 gcctgttccg cagccgggtc ttcgtgtggg gcgcggccgg cgcgacgttc gtgagcctcg
    10501 gcatgtcggg cgtgctgttc gtcgtccccc agcacctgca ggccgtgctc gggcacgacg
    10561 ctctcggcac cggtgtacgg gtgatcccca tggtggccgg gctgatggcc ggcggcctgg
    10621 ccggagagcg gctcacgacc cgcctcgggc tgcgcgtggt gatgccggcg ggcctggtcg
    10681 tgctcgccgc cgggttcttc ctgggcgccg ggaccacggt gtcgggcggg gcgtcctcgg
    10741 cgtacggcta cgtcgcggcc tggctggccg tcctcggcgc gggtgtcggc ctcgccatgg
    10801 tccccgccat ggacggcgtt ctcgccacgc tgcccgagga ccggtcgggc tccggctcgg
    10861 cgaccctgca gaccgtgcgc caggtcggcg gcgcgctggg
//
