LOCUS       NZ_JABBXA010000009     21134 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H13382 NODE_9, whole genome shotgun sequence.
ACCESSION   NZ_JABBXA010000009
VERSION     NZ_JABBXA010000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H13382
  ORGANISM  Microbispora sp. H13382
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 300695)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 300695)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Antibiotics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014161445.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 07:22:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,906
            Genes (coding)                    :: 7,786
            CDSs (with protein)               :: 7,786
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 21 of 121
            Pseudo Genes (incomplete)         :: 104 of 121
            Pseudo Genes (internal stop)      :: 8 of 121
            Pseudo Genes (multiple problems)  :: 11 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:45:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 105215
            Orig. end                         :: 126349
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBXA010000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21134
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21134
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21134
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11134](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11134)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(858..872)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     misc_feature    complement(903..917)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.5"
                     /tool="antismash"
     misc_feature    1501..1514
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.48"
                     /tool="antismash"
     misc_feature    1532..1545
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.4"
                     /tool="antismash"
     gene            1539..2174
                     /locus_tag="HHX41_RS19615"
     CDS             1539..2174
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540223.1"
                     /locus_tag="HHX41_RS19615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HNH endonuclease family protein"
                     /protein_id="WP_169981122.1"
                     /transl_table=11
                     /translation="MIFLHRTLRVTTLSLLVLPITAVALAPQAAADAGAPARRMLAQLK
                     VAKPLSIRGYSHRRFQPRWAHHKGECDAREAVLARDGRGVRRNAACQAVKGVWHSPYDG
                     KVLKSVKQTDVDHVVPLAYAWRSGAKRWSQAKRRAFANDLTRPELVVVSHSVNMAKGGQ
                     GPQSWRPPRRRYWCRYATSWITVKHHYRLFVTRKEKVALLNMLRTCGR"
     gene            complement(2202..2828)
                     /locus_tag="HHX41_RS19620"
     CDS             complement(2202..2828)
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017530.5"
                     /locus_tag="HHX41_RS19620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_182907138.1"
                     /transl_table=11
                     /translation="MNVPGSLTAQLYLLAYDPRKERVVTNYRFPYLLRAAALTDLLLMG
                     RIADDDGKVRVVSEDRLGDPVLDDLLRQLAETGPRPWRHWIGKDGRATVRAVRDELEAG
                     RWVRVELRQPFLIFNRSAVRVRDTRVVKRLAARFADAITGPASRVGDREAALVGLAAAA
                     ELGTVLPRAKRRAHKQRIDQLAERGGPAAAALHKVIQQARGASSG"
     gene            complement(2844..3086)
                     /locus_tag="HHX41_RS19625"
     CDS             complement(2844..3086)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634332.1"
                     /locus_tag="HHX41_RS19625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_182907139.1"
                     /transl_table=11
                     /translation="MATERKSILLRLDPAVHDALARWAGDELRSTNAQIEFLLRRALSE
                     AGRLPGGAGRIPRRGRPAKKQTPPPEAPAADPPDD"
     gene            complement(3090..4016)
                     /locus_tag="HHX41_RS19630"
     CDS             complement(3090..4016)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017607794.1"
                     /locus_tag="HHX41_RS19630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SPFH domain-containing protein"
                     /protein_id="WP_182907140.1"
                     /transl_table=11
                     /translation="MTDLQIAVDMPAPQTHERAARAAAGWPMLILALVGLLSAFALVPV
                     GAVLAAGGSGALGAMLIAAGVLLLLAALVVFTGLTAVAPGEARVIQLLGRYVGTVRTPG
                     LRFVAPFTQKRRVSTRIRNHETDIAKVNDADGNPIEMAAVVVWQVEDTAKAVFEVDDFV
                     EFVAFQTETAVRHIAGSYPYDGHDDMLSLRQNADEITGRLSVEIQARVASAGVKVIESR
                     ITRLAYAPEIAQAMLRRQQAGAVVAARQRIVEGAVGMVEAALARLDEHDVIELDEERKA
                     TMVSNLLVVLCGDRDVQPVVNTGSLYH"
     gene            complement(4098..5099)
                     /locus_tag="HHX41_RS19635"
     CDS             complement(4098..5099)
                     /NRPS_PKS="Domain: PKS_ER (12-327). E-value: 1.9e-45.
                     Score: 147.3. Matches aSDomain:
                     nrpspksdomains_HHX41_RS19635_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017597505.1"
                     /locus_tag="HHX41_RS19635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_182907141.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.1e-18, bitscore:
                     61.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIVQDTYGPADVLELRDVDRPSIGDDEVLVEVRAAAVDPGVWV
                     LMTGTPYLARGGFGLRRPKVPVRGRDVAGVVTAVGANVTRFRPGQEVYGTCPNGSLAEY
                     ARAPQARLAPKPANLTFEQAAAVPVSGMTALQAVRDVAGVRPGQRVLVIGASGGVGSFA
                     VQITKALGASVTGVCAAAKADFVRSLGADDVIDYTREEIDRDGARYDVVVDTAGNRPLS
                     LLRRALTPRGTLVIVGGGHTAYRFTGGMGRTFRAPLLSLFTGSMFRGQRLRPMFSRERA
                     EHLEELTRLIESGAVVPAVDRAYPLPAAPDAIRHLMEGHPAGKVVVTVAGTA"
     aSDomain        complement(4119..5063)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX41_RS19635_PKS_ER.1"
                     /evalue="1.90E-45"
                     /label="HHX41_RS19635_PKS_ER.1"
                     /locus_tag="HHX41_RS19635"
                     /protein_end="327"
                     /protein_start="12"
                     /score="147.3"
                     /tool="antismash"
                     /translation="DVLELRDVDRPSIGDDEVLVEVRAAAVDPGVWVLMTGTPYLARGG
                     FGLRRPKVPVRGRDVAGVVTAVGANVTRFRPGQEVYGTCPNGSLAEYARAPQARLAPKP
                     ANLTFEQAAAVPVSGMTALQAVRDVAGVRPGQRVLVIGASGGVGSFAVQITKALGASVT
                     GVCAAAKADFVRSLGADDVIDYTREEIDRDGARYDVVVDTAGNRPLSLLRRALTPRGTL
                     VIVGGGHTAYRFTGGMGRTFRAPLLSLFTGSMFRGQRLRPMFSRERAEHLEELTRLIES
                     GAVVPAVDRAYPLPAAPDAIRHLMEGHPAGKVVV"
     CDS_motif       complement(4602..4661)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX41_RS19635_0002"
                     /evalue="2.70E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="HHX41_RS19635"
                     /protein_end="166"
                     /protein_start="146"
                     /score="16.7"
                     /tool="antismash"
                     /translation="GQRVLVIGASGGVGSFAVQI"
     CDS_motif       complement(4860..4895)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX41_RS19635_0001"
                     /evalue="3.00E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="HHX41_RS19635"
                     /protein_end="80"
                     /protein_start="68"
                     /score="10.6"
                     /tool="antismash"
                     /translation="GRDVAGVVTAVG"
     gene            complement(5096..5329)
                     /locus_tag="HHX41_RS19640"
     CDS             complement(5096..5329)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890616.1"
                     /locus_tag="HHX41_RS19640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_182907142.1"
                     /transl_table=11
                     /translation="MVKPTRVTNRIRVLRFAHDEMTQAELAERIGVTRQTVIAIEQGRY
                     SPSLEMAFRIARVFNAPLDDVFQYPDLPEETK"
     gene            complement(5323..5751)
                     /locus_tag="HHX41_RS19645"
     CDS             complement(5323..5751)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890617.1"
                     /locus_tag="HHX41_RS19645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_182907143.1"
                     /transl_table=11
                     /translation="MTHEEKRAWIRLVVAVIAYAAYVVAILRRAGGGPLPDVPYAAAML
                     WTIGGAIGASILAEIGMAIVNPGASRVIDARDREIGRLGDYTGQAFVVIGAIAAMLMAM
                     AEWDRFWIANVIYLFFVLSAILGGITKIVLYRRSVPEW"
     misc_feature    complement(5647..5649)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5824..5837
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.87"
                     /tool="antismash"
     misc_feature    complement(5825..5838)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.04"
                     /tool="antismash"
     misc_feature    5870..5883
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            complement(5894..6745)
                     /locus_tag="HHX41_RS19650"
     CDS             complement(5894..6745)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017542087.1"
                     /locus_tag="HHX41_RS19650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_182907144.1"
                     /transl_table=11
                     /translation="MDKHGLARFLRSKRESIDPADVGLPLGRRRRTPGLRREEVAQLAY
                     ISVDHYTRLEQARGRHPSRRVLDGIARALRLSDQERAHLFRLAGEREESRSAEPASEVR
                     PSTLSLVNRLTDAAAIVVDDMCRVLAWNPLAAALFEDFSTLAGQERNVIRRYFLHPDPE
                     RRHFGMGSPERFAVTAVGYLRVAVTRYPDSRELKSLIEELLAGSEDFARLWNSQRFHID
                     RHLHQTVRHPRVGPIELDFDVLTVPDQEQQVVIFTAEPGSPAYESLRFLKVVGAEQVPA
                     DA"
     gene            6907..7806
                     /locus_tag="HHX41_RS19655"
     CDS             6907..7806
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016228.5"
                     /locus_tag="HHX41_RS19655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_182907145.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.3e-19, bitscore:
                     64.7, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIFVTGASGYVGAVVAEHLVRAGHEVVALARSDEARERVEGLGA
                     KAVLASLRDLDVLRGAAAAAEAVVHTAVDYADPDMGDIERDTLAALLDGLNDGGAFVYT
                     STGLVYPDRQGATVDEDHPVTPETSAQPYKVLGERQVLAAGHVAGTVIRAALVYGRGGS
                     GLLQGLIGAGRQNGMVPYIGDGANEWSSVHVDDLAELYVAALERREPQVVGNGVVVNAA
                     SAERTPIRRIAEAVAGLTGAQAVSLTMEQAVAAMGPAIAALTRSSPMDASRARRLFGWA
                     PERPGLIEELTTGSYTRS"
     misc_feature    complement(6953..6967)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(7807..8991)
                     /locus_tag="HHX41_RS19660"
     CDS             complement(7807..8991)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS19660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_182907146.1"
                     /transl_table=11
                     /translation="MREATVVRLRELAFRRDGSQWIVGRPDGDEFVAVPYEGMRAIELL
                     SAGATVEETERRLRAETGVDLDVGDFVRALGTLGFVEKPGAPAASAGPPTFPRLRPRHV
                     RWTLHPLLHLLVAGLIAAGIATAVVRRETLPGWRDLLWSERGTLVLASQIVVGWALIFL
                     HELAHLSAARAAGVPGRIRLGTRLQFLAVQTEVSGVWLAGRRVRLTVYLAGMATDASAC
                     SAALLLTAVVGRQPALSLVALTSLGMLATQFLVFMRTDVYFLLQDLSGCRDMYGDASAY
                     VRHLALRLLRRPSPDPLAGLPRRERRALRTYAVLLVVGTAACLGVAFAVTAPATLTLLG
                     RAVGVLAAPADPLAGLDAAAVLLSAVAFQVLWARAWWRRHGPRVRRALRTRRGR"
     gene            complement(9013..9684)
                     /locus_tag="HHX41_RS19665"
     CDS             complement(9013..9684)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF045158.2"
                     /locus_tag="HHX41_RS19665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6879 family protein"
                     /protein_id="WP_182907147.1"
                     /transl_table=11
                     /translation="MAHAGTIFDDVRQAEARVLPADAYQAEFTEEFERAPDGVWKLERA
                     QEFFEPDVASWRAMMAGDWDGSLAMLEELREFLVGYYRTRPQARRVRIVETPLTPYLQW
                     ELHVLAVRATAGERPRVLHADAVRELEHHAPLPEIVVLGPTLLYEVLYDEIGAHVGARR
                     ITDPGLVGPCLTAIKELYGRGEDVRAYVEREVAPLPPPVISDRTRALLPGYSHDTGTIR
                     P"
     gene            complement(9780..9905)
                     /locus_tag="HHX41_RS40735"
     CDS             complement(9780..9905)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS40735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_259401129.1"
                     /transl_table=11
                     /translation="MNTNEHETEPVEETASPAKTKITIRLLDKIETTTSSNSVGN"
     misc_feature    complement(9952..9967)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.65"
                     /tool="antismash"
     gene            complement(10001..11134)
                     /locus_tag="HHX41_RS19670"
     CDS             complement(10001..11134)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013094.5"
                     /locus_tag="HHX41_RS19670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_211591751.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 3.7e-20,
                     bitscore: 66.2, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 2.7e-48, bitscore: 158.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLPRVKFEHRPHRYDDGTIRIGGEIYGIAAEIADPYGWVWTALT
                     LMDGTRSRDEIAERLRLSHPEVPDAASIVEQLVATRYVEDAAAGPPAGLSERELDRYSR
                     NHAFFRAVDVAPRGDGWETQLRLKSARVVVLGLGGTGSHAAWALAAVGVGTIHCVDPDV
                     VELSNLNRQVLFGEDDIGRPKAEAAVARLRTVNSDIRVTGERRHIGSRRQLDDLIAGYD
                     ALALCADRPTGHGIRVWANRACAAANIPWAGGGYNGPLVTVGCFAPGAGACYECLSSGE
                     EARRRPGTPVNLGGPGVIATSAGVSGQLVAHALLGLLTGVPVPPAGTIQGVNLIAADHH
                     VWVRHPPRPGCPVCGTRAPAGGPKHNSFRPRTEIDAG"
     aSDomain        complement(10862..11134)
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHX41_RS19670_Pantocin_Microcin_RRE.1
                     "
                     /evalue="3.30E-21"
                     /identifier="RREFam017.1"
                     /label="HHX41_RS19670"
                     /locus_tag="HHX41_RS19670"
                     /protein_end="91"
                     /protein_start="0"
                     /score="66.2"
                     /tool="antismash"
                     /translation="MRLPRVKFEHRPHRYDDGTIRIGGEIYGIAAEIADPYGWVWTALT
                     LMDGTRSRDEIAERLRLSHPEVPDAASIVEQLVATRYVEDAAAGPP"
     gene            11373..12386
                     /locus_tag="HHX41_RS19675"
     CDS             11373..12386
                     /EC_number="2.7.7.6"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017586515.1"
                     /locus_tag="HHX41_RS19675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase subunit sigma-70"
                     /protein_id="WP_182907148.1"
                     /transl_table=11
                     /translation="MSADTRLEELGVSGLGVSGLGEVGEPVFSGLAERHRRELHVHCYR
                     MLGSFEDAEDTVQETFLRAWRRRETFEGRSTFRAWLYRIATNACLDLLAKCRPEPATGG
                     EVPWLQPYPDRLLDELPAGDADEPETVAVARETIELAYLVAVQHLAPRPRAVLILRDVL
                     GWRAKDVAELLGDSVNSVNSALQRARAGMREHLPTERQDWTGGEEDAGTRELVRRYTDA
                     SVATDVGGLAALLRDDVRCSMPPTPGLCVGRDAVVNDWIESGFEGMKHLRAVPTSVNRQ
                     PAVAFYQWRKREGAYLPLTIDVLRVTGGAITEIVTFHDDRFPRLGLPERLPADGTE"
     gene            12636..13601
                     /locus_tag="HHX41_RS19680"
     CDS             12636..13601
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013618.5"
                     /locus_tag="HHX41_RS19680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lytic murein transglycosylase"
                     /protein_id="WP_182907149.1"
                     /transl_table=11
                     /translation="MNDQPAVISPPRRRVLVAVLAAVVVPLTGCGGSAGEAASVAPRER
                     LSPPAPASSASPAPEPSVGDLPAPDEAVPKDPARLAEALTRTAGRLRDAIDDWRRTGDP
                     AKGEAPEPVVLLSLYEQRVYRYLARNPQVASRAYGKLPKAVAARTKDNVTAIRDLLSLA
                     HPVSGPIKIKVRPAEPADALLAAFRRAERRFGVEWEVLAAVMLVETKFGRVRSPSYVGA
                     RGPMQFMPGTWKAYGMGGDIDDTGDALFAAANYLHASGAPGDYRRALYAYNHSQAYVDA
                     VLLHARQMKQDIRNYYAYYTWQVYVITTKGERRLTGPDRR"
     gene            13754..16306
                     /locus_tag="HHX41_RS19685"
     CDS             13754..16306
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040347.4"
                     /locus_tag="HHX41_RS19685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6185 family protein"
                     /protein_id="WP_182907150.1"
                     /transl_table=11
                     /translation="MPLVVAALGLLIPGSGPALADGAACGFGPPRSAWVETSVTIAERG
                     HDTPVLTSTTRVGVPRDWAGSAALLGDGSGDGSTVACLLPDGGTPSVTTSADGAEVVVQ
                     STRETRLEHYGPRWSGESAGLWASRESGGTWFVALLPSTAGAPPTVDLPPGLAGARWRT
                     VVVRMPESRVRTVTPLPSQVLPGGTYVWRDAATPPRVEVAVPLSARATFQRWVDLRGQN
                     VLTVATYLGFALPYLLLAWLLVLLHRRSSDRRSGDRGSGDRGSGDRGERALVRLVLGTL
                     AAITTVEAITVVLVLTEAGFLAHLIGLTDGAAVAILVAPLCAAAWRTARTRIRRAGTAP
                     TRSGPTRSAPTRSAPTRSAPTRSGLTAFAAVVLGGVVLVAVCAYAPLSMRYFPSPGEPA
                     VVASGVATALLLTAAAWAVAVRAARIPGGRTPRAVRVLLRWSVPGLALLTLAFEAHAVV
                     VRMGSLADVVESPFLLLRSVAYLMWPLVVLLLLLLLRLHGRRTETVGPLTTWLVVFLFV
                     VGTIRWPGTYAGMPVPLAALVGLAVLPLLLRLTRRAEAADPGVSRRRLAMIVEEYRDLE
                     AREKGLRRRWAAGDMDDDAYHRENGPVVDRIRGLRMEIGLDPDREDGISPLDLALSRGP
                     GVSWWANARLAARYASYVGAPAAVFLIWATWSTDSRGRDGWLDRLGDPNGFYGLAGDLI
                     GGLLIWPVAGFVLGALWRRLPGRRGYLKGVVPVLAYAAATGAHAVLNNVIGQAPVRGSL
                     VRVLLLFLVLTVVAVLMDARTLQTRPGGLASRLTPVAVVYRLGTAGSGVALIVAQAAAI
                     LGLWSQLRNGIDITSQVDTSTQASLPADAQLLQGRAGD"
     gene            complement(16377..18134)
                     /locus_tag="HHX41_RS19690"
     CDS             complement(16377..18134)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132890.1"
                     /locus_tag="HHX41_RS19690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_182907151.1"
                     /transl_table=11
                     /translation="MPFGHHRFVRRILTVVAAVVPAAAPAVAGPVLGTTSADAAVTCQV
                     TYTSTQWGTGSGGFTAAVSVKNSGDPLTDWTLTFTFPGSQRVTQGWSAQWSQSGARVTA
                     KSESWNRPVASGGSFQIGFNGTWTGSNPPPTDFAVNGVPCQVAGTSPSPSPSPSPDVPV
                     DNPFVGVKGYVDPGWAADVESSAVRVDDATAQRIRGLKTTTTAVWLDRIADVTGGSGVA
                     RTLKDHLDTAVEQRAGYLTLVLHNLPDRDCRSRVSDAELHEQQNGLNRYKTEYVDAIAA
                     LLAKPEYRNLRVAAVVEPRALIDLIVGGAVDTYPCEQAAGSGVYVMGIRYALDKLAPLP
                     NVYTYLDAGSAGWAGWETNFTALASLVTETVRGTARGLNGLDGIATNVGDYIPLDEPFL
                     TDPYQTVSGQPIIQSRFIDWNPYLNERSYAVAMRAALIAKGFPGSLGVVVDTSRNGWGG
                     PARPTAASTSGDVNTYVDQSRVDRRPSRGAECNQNGAGLGTRPVAAPAPGVDAYLWIKR
                     PGESDGVGGPLLPEGSDRLIDYRCDPNGSLTPGTDGFRPTGALPNAPLIGDWHHEQFVM
                     LVNNAYPAL"
     gene            complement(18359..19324)
                     /locus_tag="HHX41_RS19695"
     CDS             complement(18359..19324)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038083.1"
                     /locus_tag="HHX41_RS19695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CU044_5270 family protein"
                     /protein_id="WP_182907152.1"
                     /transl_table=11
                     /translation="MDDLRLLREMRAEVPDPGPEWLVPARARLLRRVRAWHLPRFGRRL
                     LLAGALGGAASVVIATRPHEPGGVVRPATVRLDSATVLRQAAEVAESRPRRAVPRPDQW
                     HYTRTLDKQANDDSGTTQEGWIRYDGKQTAGYGEDGRMHVSDVPPDPGDDDLSPQQYDA
                     KLRRLPTDPDDLLAHVSGDRHWIDLPVEEGVKKNVEPPDARAFRVIFLYLERHVVMPPK
                     LEGAMFRALMRIPHVVVDKDVADAAGRRGLGIRFDWGADPGTLSYHILDPRTYRYLGSR
                     MVWVRDEYVEGDSTPAFRAGSVWATALLASGIVDRPGRRL"
     gene            complement(19317..19916)
                     /locus_tag="HHX41_RS19700"
     CDS             complement(19317..19916)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570935.1"
                     /locus_tag="HHX41_RS19700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_310742072.1"
                     /transl_table=11
                     /translation="MIPEAPPDRVDDAELIQRSRRDPEAFADLFDRHASALHRYVARRL
                     GASLADDVVSDTFLAAFRKRERYDPAQPDARPWLYGIAANLIGRHRRTEIRFYRALVRT
                     GVDEVAEPYADRVNQRVSAQSAQRGLAKALAGLSAGDRDVLLLVAWADLTYEEVARALD
                     IPVGTVRSRLHRARAKTRAALGGDDPSATSEEPLHG"
     misc_feature    complement(19398..19400)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(19983..19994)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.49"
                     /tool="antismash"
     gene            complement(20009..20443)
                     /locus_tag="HHX41_RS19705"
     CDS             complement(20009..20443)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019013.5"
                     /locus_tag="HHX41_RS19705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_169981165.1"
                     /sec_met_domain="PF07366 (E-value: 1.7e-19, bitscore: 64.2,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVLRAVDRLRQAINRHDLDALAQCFDERAVLVAPDGIAESREE
                     IASYYGQWMEAYPNMVITPQSVTMFGDTVAAEFTISGTHKGPLLVPGGDVLEGTGRPIL
                     VRSCSFSTVEEGLILSHRLFYDQLEMAAQIGGCLCFSDRP"
     misc_feature    20428..20442
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.88"
                     /tool="antismash"
     misc_feature    20519..20533
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.04"
                     /tool="antismash"
     gene            20790..>21029
                     /locus_tag="HHX41_RS42345"
                     /pseudo=""
     CDS             20790..>21029
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="HHX41_RS42345"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRWFTVCARVFHLTHLVGPHPGASSQRLAWLASRSDGVPAGSAY
                     LRLSTAAGHEHLAELDLHVHPAERRAGVGSRLLAA"
     misc_feature    20796..20814
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 20.85"
                     /tool="antismash"
ORIGIN
        1 caccgtgcgg cggcggcaga tcggctggct gctgtacgcc accgccgcca acctgatcgt
       61 cgaggtgtgg tggcaccagt cgccgctgtc gctcgtcacc agcgccgccg tgcccgtcgc
      121 gatcgccgtc gcggtcacgc actaccggct gtacgacatc gacacgctgg tcagcaggac
      181 cgtggtcgtc accggagttc tggcgtcggt caccgcgatc tacttcggcg tcggggtgtt
      241 gtggggggtc ttcgtctcgg agtacgggca gatccaggga ctggtggcgg cgctgttcgc
      301 gggggcgttc atccagccgc tgcggcgccg gctgcggcgg ctgctcgacc gtgtcttcta
      361 cggccccgtc ggggatcccg aggcgctcaa gcagcggctc acccgcgagg tgcacgccgc
      421 cgacccggtc accgcgctcg cctccgtcgc cgccgcggta cgtcagggcc tggcggtccg
      481 gggtgtggcc gtcgaggtgt acgacgggcg gccgcgctac gtcgagagcg gctgtgtcga
      541 cgccgcgcgc gtggtgccgc tggtgtggca cggcgaggac gtcggccggc tgctgatcgg
      601 cgcacccggc ccgcgccgct tccccgccgc ccacaacgac cggttgatca gtgcggtgac
      661 gccgtacgtc gccgacatcg cccatgccgt acggctctcc gcggatctgc agcgttcgcg
      721 cgagcggatc ctgagcgccc gggaggagga gcgccgcagg ctccgccgcg acctgcacga
      781 cggtctaggc caggcgctcg ccgccatggc gatgacgatc accatggccc ggcggacgct
      841 gcggacgtca ccgcagcagg ccgagcggat cctgctcgac ctgcgtacgg ccatggacgg
      901 agtggccggc gagatccgcg aactcgtcta cggcctgcgt ccgcccgtgc tcgaccagct
      961 ggccctggag ggagccgtcc gtgcgctcgc cgccgaggcg atggggggcg gcgcgggctc
     1021 ggacacccca cccggcccgc gagcggcccg ggtgagcggg agcgacggcg cgataaccga
     1081 tcgagccacc gcggtcgccg tggcggacgg ggacgagagg ggccgggccg gtggtcatgc
     1141 cccgcggatc acggtgtcgg tgagcgggga tctgacggat cttcccgccg ccgcggaggt
     1201 ggcggtctac cggatcgtcc aggaggcgct gaccaacgtg ctccggcacg cgaacgccac
     1261 gaccgtgtcc gtgacgctgc acaacggcgc ggggacgctg accctgcggg tgcgtgacga
     1321 cggcgtcggg ctgccggagt cgccgcgcgg cggggtgggc ctggcctcga tgcgggagcg
     1381 cgccgccgag gtgggcggct tctgcctgat ctcctccccg cccggcggcg gcgccctcat
     1441 cgaggtctcc ctccccgtgc ggaccgcctc caccatccgc tgaccgtcgc agcgcatatc
     1501 gtcacgctca gtggggagta tttggtatgg ctgtaactat gatcttcttg caccgcacgc
     1561 tccgagtcac cacgctttcc cttctggtcc tccccatcac cgctgtcgcg ctcgccccgc
     1621 aggccgcggc cgacgccggg gcgccggccc gccgcatgct ggcccagctg aaggtcgcca
     1681 agccgctgtc gatccgcggg tacagccatc ggcggttcca gccgcgctgg gcgcatcaca
     1741 agggggagtg cgacgcgagg gaggcggttc tcgcccgcga cgggcggggc gtgcgcagga
     1801 acgcggcgtg ccaggccgtg aagggcgtct ggcacagccc gtacgacggc aaggtgctga
     1861 agagcgtgaa acagaccgac gtcgaccacg tcgtcccctt ggcgtacgcc tggcgctccg
     1921 gcgccaagcg atggagccag gcgaaacggc gcgcgttcgc caacgacctc acccgtcccg
     1981 agctggtcgt ggtgagccac tccgtcaaca tggccaaggg aggccaggga ccgcagagct
     2041 ggcgtccgcc gcgccgccgc tactggtgcc gctacgcgac ctcgtggatc acggtgaagc
     2101 atcactaccg gctcttcgtc acccggaagg agaaggtggc cctgctcaac atgctccgca
     2161 cctgcggacg atgagcgggc ccgcgcggcc ggcgggcggg ctcagccgct gctcgcgccg
     2221 cgggcctgct ggatgacctt gtggagggcc gccgccgccg ggccgccgcg ttcggccagc
     2281 tggtcgatgc gctgcttgtg cgcgcgccgt ttcgcccgcg ggaggaccgt gccgagttcc
     2341 gccgcggcgg ccagcccgac gagggccgcc tcgcggtcac cgacccggga cgccggcccg
     2401 gtgatggcgt cggcgaaccg tgccgcgagg cgcttcacca cccgcgtgtc gcgtacgcgg
     2461 acggcgctcc tgttgaagat caggaacggc tggcgcagct ccaccctgac ccagcggccc
     2521 gcctccagct cgtcccggac cgcccggacc gtggcccggc cgtccttgcc gatccagtgc
     2581 cgccacggcc ggggtcccgt ctcggcaagc tggcggagca ggtcgtcgag gaccgggtcg
     2641 ccgagccggt cctccgacac cacgcgcacc ttgccgtcgt cgtcggcgat ccggcccatg
     2701 agcagcagat cggtgagcgc ggccgcgcgc agcaggtagg ggaagcggta gttcgtcacc
     2761 acccgctcct tgcgggggtc gtaggccagt agatagagct gggccgtcag ggaaccgggg
     2821 acgttcattg gactgccctc ctctcagtcg tcgggcgggt cggcggcggg ggcttccgga
     2881 ggcggcgtct gcttcttggc gggcctgccg cgccggggga tgcgaccggc gccgcccggg
     2941 agccgccccg cctccgacag cgcccggcgc agcaggaact cgatctgggc gttggtgctg
     3001 cgcagttcgt cgccggccca gcgggccagc gcgtcgtgca ccgcggggtc cagccgcagc
     3061 aggatgctct ttctttcggt cgccacggtc tagtggtaca gggagccggt gttcaccacg
     3121 ggctgcacgt cgcggtcgcc gcacaggacg acgagcaggt tgctgaccat ggtggccttg
     3181 cgctcctcgt cgagctcgat cacgtcgtgc tcgtcgaggc gggccagggc ggcctcgacc
     3241 atgccgaccg cgccctccac gatccgctga cgggccgcga cgaccgctcc ggcctgctga
     3301 cggcgcagca tcgcctgcgc gatctcggga gcgtacgcca gccgggtgat gcgcgactcg
     3361 atgaccttga ctccggccga ggccacccgc gcctggatct cgaccgacag gcggcccgtg
     3421 atctcgtccg cgttctggcg cagggacagc atgtcgtcgt gcccgtcgta cgggtagctg
     3481 ccggcgatgt gacggaccgc ggtctcggtc tggaaggcga cgaactccac gaagtcgtcg
     3541 acctcgaaga cggccttcgc cgtgtcctcg acctgccaca cgaccacggc ggccatctcg
     3601 atcgggttgc cgtcggcgtc gttgaccttg gcgatgtcgg tctcgtggtt gcggatccgg
     3661 gtggacacgc ggcgcttctg ggtgaaggga gccacgaacc ggaggccggg cgtgcggacc
     3721 gtgcccacgt agcggccgag cagctggatc acgcgcgcct caccgggggc gaccgcggtg
     3781 agcccggtga agacgacgag ggccgccagg aggagcagca ccccggcggc gatcagcatg
     3841 gctcccaggg cgccgctgcc gccggccgcg aggacggctc cgaccgggac cagcgcgaac
     3901 gcgctcagca ggcccaccag ggccaggatc agcatgggcc atcccgcggc tgctcgcgcc
     3961 gcccgctcgt gggtctgggg ggccggcatg tcgacggcga tctgcaggtc tgtcatgtct
     4021 tctcctcgat gtctagcatg acactagcaa agtgatatca cttttcgcca gacccgagga
     4081 gcccgggaac tcgggactca ggccgttccc gccacggtga cgacgacctt gccggcgggg
     4141 tggccttcca tgaggtgccg gatcgcgtcg ggcgcggcgg ggaggggata ggcgcggtct
     4201 accgccggga cgacggcgcc ggactcgatg agccgggtca gctcctccag gtgctcggcg
     4261 cgctcgcggg agaacatcgg gcgcagccgc tgccccctga acatcgaccc cgtgaacaac
     4321 gacagcagcg gcgcccggaa cgtgcgtccc atgccaccgg tgaagcggta cgcggtgtgc
     4381 ccgccgccga cgatcaccag cgtgccgcgc ggggtcaggg cacgccgcag cagggacagc
     4441 ggccggttgc ccgcggtgtc gacgacgacg tcgtagcgtg cgccgtcgcg gtcgatctcc
     4501 tcgcgggtgt agtcgatgac gtcgtcggcc ccgagcgacc gcacgaagtc cgccttcgcc
     4561 gccgcgcaca caccggtgac gctcgcgccg agcgccttgg tgatctgcac ggcgaacgac
     4621 cccacgcctc ccgacgcgcc gatcaccagc acccgctgcc ccgggcgcac gccggcgacg
     4681 tcgcgtacgg cctgcagcgc cgtcatgccg gagaccggca ccgcggcggc ctgttcgaac
     4741 gtgaggttgg ccggcttcgg cgcgaggcgg gcctgcggcg ccctcgcgta ctcggcgagc
     4801 gaaccgttgg ggcaggtgcc gtacacctcc tgcccgggcc ggaagcgggt gacgttggcg
     4861 ccgacggccg tcaccacccc ggcgacgtcg cggccccgga cgggaacctt ggggcggcgc
     4921 agcccgaatc ccccacgcgc gaggtacggc gtgccggtca tcaggaccca caccccggga
     4981 tccacggcgg ccgcgcggac ctcgacgagc acctcgtcgt cgccgatcga ggggcggtcg
     5041 acgtcacgca gttcgagcac gtcggccggg ccgtacgtgt cctggacgat ggccttcatt
     5101 tcgtctcctc tgggaggtcg ggatactgga acacgtcgtc gagcggggcg ttgaacaccc
     5161 gggcgatccg gaaggccatc tccagggacg gcgagtaccg gccctgctcg atggcgatga
     5221 cggtctgtct ggtcacgccg atgcgttcgg cgagttcggc ctgggtcatc tcgtcgtggg
     5281 cgaatcgcag cacgcggatg cggttcgtca cgcgtgtggg cttcaccact ccggaacgct
     5341 cctgcgatag agaacgatct tggtgatgcc gccgaggatc gccgacagga cgaagaagag
     5401 gtagatcacg ttggcgatcc agaaccggtc ccactccgcc atggccatga gcatcgccgc
     5461 gatcgccccg atgaccacga acgcctgacc ggtgtagtcg cccagccgcc cgatctccct
     5521 gtcgcgggcg tcgatgacgc gcgaggcccc cgggttgacg atcgccatcc cgatctcggc
     5581 caggatcgac gcgccgatcg ccccgccgat cgtccacagc atggcggcgg cgtacggcac
     5641 gtcgggtaac gggcctccgc ccgcccgcct gaggatggcg acgacgtacg ccgcgtaggc
     5701 gatcacggcg acgaccagcc ggatccaggc gcgcttctcc tcgtgggtca tgatcgattc
     5761 ccttcgggtg tacagaatct ttgacaccct caaggtaatc cgtctttgac ttgatgtaca
     5821 gaagttttta catcgaatcc gttggcggag ccgggcctgc cgagcgggga gaacatgcgt
     5881 ccgcgggcgc gggtcaggcg tcggcgggca cctgctcggc gccgacgacc ttgaggaacc
     5941 gcagggactc gtaggccggg gacccgggct cggcggtgaa gatgaccacc tgctgctcct
     6001 ggtcgggcac ggtgagcacg tcgaagtcca gctcgatcgg cccgacgcgc gggtgccgca
     6061 cggtctggtg gaggtgacgg tcgatgtgga accgctggga gttccacagc cgggcgaagt
     6121 cctcgctccc cgccagcagt tcctcgatca ggctcttcag ctcgcggctg tccggatagc
     6181 gggtcacggc gacgcgcagg tagccgaccg ccgtgacggc gaaccgttcc gggctgccca
     6241 tgccgaagtg ccgccgctcc gggtcgggat gcaggaagta gcgccggatg acgttgcgct
     6301 cctggccggc cagggtggag aagtcctcga acagggccgc cgccagcgga ttccaggcca
     6361 gcacgcggca catgtcgtcc acgacgatcg cggcggcgtc ggtcagccgg ttgaccaggc
     6421 tcagtgtgct cgggcgcacc tcgctcgcgg gctccgcgga ccggctctcc tcccgctccc
     6481 cggccaggcg gaacaggtgg gcgcgttcct ggtccgacag gcgcagggcg cgggcgatgc
     6541 cgtcgagcac ccgccgcgac gggtgacggc cccgcgcctg ttccagccgt gtgtagtggt
     6601 ccaccgagat gtacgcgagc tgggcgacct cctcgcgccg cagtccgggg gtgcggcggc
     6661 ggcgtcccag gggcaggccg acgtcggcgg ggtcgatgct ctcccgcttg ctccggagga
     6721 accgcgccag gccatgcttg tccatgtttg tgaccgtacg ccgggcatcg ggtgcgcgga
     6781 ccccctcagc cacggactct tggtccctgg ctgtgcggga cgccgggggc gacggtgggg
     6841 ttggcagcga ccggcggcga acacggacgc gccgcggtca cccgacctca tggaaggcac
     6901 acgatcatgc ggatcttcgt caccggtgcg agcggctacg tcggcgcagt cgtggccgag
     6961 cacctcgtca gggccggcca cgaagtggtc gccctggccc gctcggacga ggcgcgcgag
     7021 cgggtcgaag ggctgggcgc caaggcggtg ctcgcgagcc tgcgggacct cgacgtcctg
     7081 cgcggcgccg ccgcggcggc cgaggccgtg gtccacaccg ccgttgacta cgccgatccg
     7141 gacatgggcg atatcgagcg cgacaccctc gcggcgctgc tggacggcct caacgacggc
     7201 ggcgcgttcg tctacaccag cacgggactg gtctacccgg accggcaggg cgcgaccgtg
     7261 gacgaggacc accccgtcac ccccgagacg tcggcgcagc cgtacaaggt cctcggcgag
     7321 cggcaggtcc tggcggccgg ccacgtggcg ggcacggtga tccgggcggc gctggtctac
     7381 gggcgcggcg gatcgggcct gctccagggg ctcatcggcg ccggcaggca gaacgggatg
     7441 gtgccctaca tcggcgacgg cgccaacgag tggtcgtcgg tgcacgtcga cgacctcgcg
     7501 gagttgtacg tcgccgcgct ggagcgccgc gagccccagg tggtcggcaa cggggtcgtc
     7561 gtcaacgccg cgtcggccga gcggaccccg atccggcgga tcgccgaggc ggtcgccggc
     7621 ctgaccggcg cccaggccgt gtcgctgacg atggagcagg cggtcgccgc gatggggccg
     7681 gccatcgccg cgctcacccg ttcgtcgccg atggacgcct cgcgggcccg gcggctgttc
     7741 gggtgggccc cggagcggcc cgggctgatc gaggagctga cgaccggctc ctacacgcgg
     7801 tcctgatcaa cgcccccgcc gcgtacgcag cgcgcgccgt acgcgcgggc cgtgcctgcg
     7861 ccaccaggcc cgcgcccaga gcacctggaa cgcgaccgcg gacagcagca ccgccgcggc
     7921 gtccagcccg gcgagcgggt ccgcgggggc ggccagcacg cccacggccc ggccgagcag
     7981 cgtcagcgtc gccggcgccg tcaccgcgaa cgccacaccc aggcaggccg cggtgcccac
     8041 gaccagcagc accgcgtacg tacgcagggc gcgccgctcc cggcgcggca gcccggcgag
     8101 cgggtcgggg gagggacggc ggagcagccg cagcgccaga tggcggacgt aggcggaggc
     8161 gtcgccgtac atgtcgcggc acccgctcag gtcctgcagc aggaagtaga cgtcggtgcg
     8221 catgaacacg aggaactgcg tggccagcat gccgagcgag gtcagcgcga ccagcgaaag
     8281 cgcgggctgg cgacccacga cggcggtcag gaggagcgcg gccgaacagg ccgaggcgtc
     8341 ggtcgccatc ccggcgaggt agaccgtcag gcggacgcgc cgcccggcca gccagacgcc
     8401 ggagacctcg gtctggacgg ccaggaactg cagccgggtg ccgagccgga tcctgcccgg
     8461 caccccggcg gccctggcgg ccgacaggtg ggccaactcg tgcaggaaga tcagcgccca
     8521 gccgaccacg atctgcgacg cgagcacgag cgtgccgcgc tcgctccaca gcaggtcgcg
     8581 ccagccgggc agcgtctccc gccgtacgac cgccgtcgcg atcccggcgg cgatcaggcc
     8641 ggcgaccagc aggtggagca gcgggtgcag cgtccaccgc acgtgccggg gacgcaaccg
     8701 gggaaaggtc ggcggcccgg cggaggcggc cggggcgccg ggcttctcca cgaagcccag
     8761 cgtgcccagg gcgcggacga agtcgccgac gtcgagatcc acgcccgtct cggcgcgcag
     8821 ccgccgttcc gtctcctcga ccgtggcgcc cgccgacagc agctcgatgg cccgcattcc
     8881 ctcgtacggc acggcgacga actcgtcccc gtccgggcgg ccgacgatcc actgcgaacc
     8941 gtcccgccgg aacgccagct cgcgcagccg gaccacggtg gcctctcgca acgcgggcct
     9001 ccaggtgcgg ggtcaggggc ggatggtccc ggtgtcgtgg gagtagccgg gcaggagggc
     9061 gcgtgtcctg tcggagatca cgggcggtgg cagcggggcg acctcccgct cgacgtacgc
     9121 ccgcacgtcc tcaccacggc cgtagagctc cttgatcgcg gtcaggcagg ggccgacgag
     9181 gccggggtcg gtgatccgcc gggcgcccac gtgggcgccg atctcgtcgt acagcacctc
     9241 gtagagcagc gtggggccga gcacgacgat ctcgggcagc ggcgcgtggt gctccagctc
     9301 ccgcacggcg tccgcgtgca gcacccgggg acgctcgccc gccgtcgccc gtacggcgag
     9361 gacgtgcagc tcccactgga gatagggggt gagcggcgtc tccacgatgc ggacccggcg
     9421 ggcctggggc cgggtccggt agtagccgac gaggaactcc cgcagttcct ccagcatggc
     9481 gagcgacccg tcccagtcgc cggccatcat cgcccgccag ctcgccacgt cgggttcgaa
     9541 gaactcctgg gcgcgttcga gcttccacac cccgtcgggg gcccgctcga actcctcggt
     9601 gaactcggcc tggtacgcgt ccgcgggcag gacccgcgcc tcggcctgcc gtacgtcgtc
     9661 gaagatggtc ccggcgtgtg ccacccttcc ctccctgggc actccctggt gctggctctc
     9721 gtcggccgag gcgtgcggac ggccccgcgg cacccccgca cgcctcgggc ggtgcttcgt
     9781 cagttgccga cgctgttgct gctggtcgtg gtctcgatct tgtcgagcag ccggatggtg
     9841 atcttcgtct tggccggcga ggcggtctcc tcgacgggtt cggtctcgtg ctcgttcgtg
     9901 ttcatccggt tcctctctct ggaggggaca tggatgttct cgcgagaacg cgttcatgat
     9961 tcgcctttga ctgggggcag tcaaggattt ctctattcat tcaaccggca tcgatttcgg
    10021 tcctcggccg gaatgaattg tgtttcggcc cgccggccgg ggcccgcgtg ccgcacaccg
    10081 ggcagccggg gcgcggcgga tgcctgaccc acacgtggtg gtccgcggcg atcaggttga
    10141 cgccctggat ggtgccggcc ggcggcacgg gcaccccggt cagcagcccg agcagggcgt
    10201 gggcgacgag ctggccggac acgcccgccg aggtggcgat cacgcccggc ccgccgaggt
    10261 tcaccggcgt gccggggcgg cgccgcgcct cctcgccgct gctcaggcac tcgtagcagg
    10321 cgcccgctcc cggcgcgaaa caccccacgg tgacgagtgg gccgttgtat ccgccgccgg
    10381 cccaggggat gttcgcggcg gcgcaggcgc ggttggccca cacccggatg ccgtgcccgg
    10441 tgggccggtc cgcgcacagg gcgagcgcgt cgtagcccgc gatcaggtcg tccagttgcc
    10501 gcctgctgcc gatgtggcgg cgctcgcccg tgacccggat gtcggagttg acggtccgca
    10561 gccgcgcgac ggccgcctcc gccttcgggc gccctatgtc gtcttcgccg aagaggacct
    10621 ggcggttgag gttggacagc tcgaccacgt cggggtccac acagtggatc gtgccgacgc
    10681 cgacggcggc gagcgcccac gccgcgtggc tgccggtgcc gcccaggccg agcaccacga
    10741 cccgcgcgga cttcagccgc agctgggtct cccagccgtc gccgcgcggc gcgacgtcga
    10801 cggcgcggaa gaacgcgtgg ttcctgctgt agcggtcgag ctcgcgctcg ctcagcccgg
    10861 cgggcggccc ggccgcggcg tcctccacgt atcgggtggc gaccagttgc tcgacgatcg
    10921 acgcggcgtc cggcacctcc ggatgggaca ggcgcagccg ctcggcgatc tcgtcgcggg
    10981 accgggtgcc gtccatcagc gtgagggccg tccacaccca gccgtacggg tccgcgattt
    11041 cggcggcgat cccgtaaatc tcaccgccga tgcgaatggt gccgtcgtcg taccggtgag
    11101 gccggtgctc gaatttcacg cggggcagtc gcacgtgacg acgtttagtg ggcgataact
    11161 aggtgagtca acaccgattt tcgcgttgcg gaaaaagggg tcggccgtaa aacgttcccg
    11221 catcgccggc gtcgcatcgt cgtgtgctcg ccaccggatc cgtcaccgac tctgtcactg
    11281 aatcagccat gccggccgac cgtggtgatg agttgtcgcg cccgcacccg tcacacctac
    11341 gacgggacac gacgaggcgg gaggatgacg cgatgagtgc ggacacgcgg ctggaggagc
    11401 tgggcgtgag cggtctgggc gtgagcggtc tgggcgaggt cggcgagccg gtgttctcgg
    11461 ggctggcgga gcggcaccgg cgggagctgc acgtgcactg ctaccggatg ctcgggtcgt
    11521 tcgaggacgc cgaggacacc gtgcaggaga cgttcctccg tgcctggcgg cggcgggaga
    11581 ccttcgaggg gaggtcgacg ttccgggcct ggctgtaccg gatcgccacc aacgcctgcc
    11641 tggacctgct cgccaagtgc cgcccggagc ccgcgaccgg cggcgaggtg ccgtggctgc
    11701 agccctaccc ggaccggctg ctcgacgagc tgcccgcggg cgacgcggac gagccggaga
    11761 ccgtcgccgt cgcgcgggag acgatcgagc tggcgtacct ggtcgcggtc cagcacctcg
    11821 cgccgcgccc gcgggccgtg ctgatcctgc gggacgtgct cggctggcgg gcgaaggacg
    11881 tcgcggagct cctcggggac tccgtcaact ccgtgaacag cgcactgcag cgggcccgcg
    11941 ccggcatgcg ggagcacctg cccaccgagc ggcaggactg gaccggcggc gaggaggacg
    12001 ccgggacgcg cgagctggtg cgccgctaca ccgacgccag cgtggccacg gacgtcggcg
    12061 ggctcgccgc actgctgcgg gacgacgtcc gctgctcgat gccgcccacg ccgggcctgt
    12121 gtgtcggccg cgacgcggtg gtgaacgact ggatcgagag cggcttcgag ggcatgaagc
    12181 acctgcgcgc cgtccccacc tcggtgaacc ggcagcccgc cgtcgccttc taccagtggc
    12241 gcaagcggga gggcgcgtac ctgccgctga cgatcgacgt cctgcgcgtc accggcgggg
    12301 cgatcaccga gatcgtcacg ttccacgacg accggttccc gcggctcggg ctgccggagc
    12361 gcctgcctgc ggacggcacc gagtaggccc ggtgcggacg cagtaggccc ggtgcggacg
    12421 cggagtaggc ccggtgcgga cgctcgcgct gcgaggtggc gcgcgtgtcg cggcaccggc
    12481 ctcgtcgcca cgctcggggc gatggcggcc accaccctcg cggccgcgct cgccccgccg
    12541 ggcgattcct gtggacggcc ctgtcgcggc tgaggcctgg cacctacgcg tgccggaggg
    12601 catggatcgt caccgctggg catacgttgg tgacgatgaa cgatcagcct gctgtgatct
    12661 caccgccgcg ccgccgggtg ctggtcgccg tgctcgccgc cgtggtcgtc ccgctgacgg
    12721 gctgcggcgg ctcggcgggg gaggccgcct cggtcgcccc gcgcgagcgc ctgtccccgc
    12781 ccgcgccggc gtcctccgcg agcccggcgc cggagccgtc cgtaggggac ctgcccgccc
    12841 cggacgaggc ggtgccgaag gaccccgcgc ggctggccga ggccctcacc cgtacggccg
    12901 gacgactgcg cgacgcgatc gacgactgga ggcgtacggg cgaccccgcg aagggggagg
    12961 cgcccgagcc cgtggtcctg ctgtccctgt acgagcaacg cgtgtaccgc tacctcgccc
    13021 gcaatcccca ggtcgcctcc cgcgcctacg ggaaactgcc caaggcggtg gccgcgcgga
    13081 cgaaggacaa cgtgacggcc atccgcgacc tgctctccct cgcccacccc gtcagcggcc
    13141 cgatcaagat caaggtcaga ccggcggaac cggccgacgc cctgctcgcg gccttccggc
    13201 gcgccgagcg ccggttcggc gtcgagtggg aggtgctggc ggcggtgatg ctcgtcgaga
    13261 ccaagttcgg ccgggtgcgc tcgccgagct acgtgggcgc cagggggccg atgcagttca
    13321 tgccgggcac ctggaaggcg tacggcatgg gcggcgacat cgacgacacc ggcgacgccc
    13381 tgttcgccgc ggccaactac ctccacgcct cgggtgcgcc cggcgactac cggcgcgcgt
    13441 tgtacgccta caaccactcc caggcgtacg tggacgccgt cctgctgcat gcccgccaga
    13501 tgaagcagga catcaggaac tactacgcct actacacctg gcaggtctac gtgatcacca
    13561 cgaaggggga gcgccgcctg accggccctg accgcaggtg atgccgcggg agggacggtc
    13621 ctcggggaat cgtccgtaac caatgccgct ttccgtgcga ctcatccttg ggggatcgat
    13681 cgcgtacggg aggcgggttg tgcgtcgggt gacgagtggt gcggggacga agccggtcgg
    13741 gatcctcgct gtggtgccgc tcgtcgtggc ggcgctcggc ctgctgattc cgggctcggg
    13801 gccggcgctc gcggacgggg cggcgtgcgg gttcgggcct ccccgctcgg cctgggtgga
    13861 gacgtccgtg accatcgcgg aacgcggcca cgacactccc gtgctgacaa gcacgacgcg
    13921 ggtcggcgtc ccccgtgact gggcggggtc cgccgctctg ctcggcgacg ggagcggcga
    13981 cgggagcacg gtcgcctgcc tgctgccgga cggcggcacg ccgagcgtca cgacgtcggc
    14041 cgacggcgcc gaggtggtgg tccagagcac gcgggagacc cgcctggagc actacggccc
    14101 ccgttggagc ggggagtccg ccgggctgtg ggcgagccgc gagtccggcg ggacctggtt
    14161 cgtcgcgctg ctgccctcga ccgcgggcgc gccgccgacc gtggacctgc cgcccgggct
    14221 ggccggcgcg cgctggcgga ccgtggtcgt caggatgccg gagtcccggg tgcgcacggt
    14281 gacgcctctg ccgtcgcagg tgctccccgg cggcacctac gtctggcggg acgccgccac
    14341 cccgccgcgc gtcgaggtcg ccgtgccgtt gtccgcgcgg gcgacgttcc agcgctgggt
    14401 ggacctgcgg gggcagaacg tgctcacggt cgcgacctac ctgggcttcg cgctgccgta
    14461 cctgctgctg gcctggctgc tcgtgctgct ccaccggcga tcgagcgacc ggcgatcggg
    14521 cgaccggggc tcgggcgacc ggggctcggg cgaccggggc gagcgcgccc tcgtcaggct
    14581 cgtcctcggc accctggcgg cgatcaccac ggtggaggcg atcacggtcg tcctcgtgct
    14641 caccgaggcg ggcttcctgg cccacctgat cggcctgacg gacggggcgg cggtcgccat
    14701 cctggtggcg ccgctctgcg cggccgcgtg gcggacggca cgcacgcgga tccggcgcgc
    14761 cggcacagcg cccacccgtt cgggacccac ccgttcggcg cccacccgtt cggcgcccac
    14821 ccgttcggcg cccacccgtt cggggctcac cgcgttcgcc gcagtggtgc tcgggggagt
    14881 ggtgctcgtc gccgtctgcg cctacgcgcc cctgtccatg cggtacttcc ccagcccggg
    14941 ggagcccgcg gtggtcgcgt cgggcgtcgc gacggcgctg ctgctcaccg cggcggcgtg
    15001 ggcggtcgcg gtccgggccg cccggatccc gggcggacgg acgccccggg ccgtccgcgt
    15061 gctgctgcgc tggagtgtcc cgggactggc gctgctgacc ctggcgttcg aggcccacgc
    15121 ggtcgtcgtg cgcatgggaa gcctggcgga cgtggtcgaa tcgcccttcc tcctgctgcg
    15181 aagcgtcgcg tacctgatgt ggccgctggt ggtgctcctg cttctcctgc tgctgcgcct
    15241 gcacgggcgg cgtacggaga ccgtcgggcc gctcaccaca tggctcgtcg tcttcctgtt
    15301 cgtcgtgggc acgatcaggt ggcccggcac gtacgcgggg atgcccgtcc cgctcgccgc
    15361 gctcgtcggc ctggcggtgc tgcccctgct gctgcggctg acgcgacggg ccgaggccgc
    15421 ggacccgggc gtgtcgcggc gacggctggc gatgatcgtc gaggagtacc gggacctgga
    15481 ggcgcgggag aagggcctgc ggcggcgctg ggccgcgggc gacatggacg acgacgccta
    15541 ccacagggag aacgggccgg tcgtcgaccg catccgcggg ctccggatgg agatcggcct
    15601 cgatcccgac agggaggacg ggatcagccc gctcgacctg gcgctgtcgc gcggcccggg
    15661 cgtgtcgtgg tgggccaacg cgcggctcgc cgcgaggtac gcgtcctacg tgggggcgcc
    15721 cgccgccgtg ttcctcatct gggccacctg gagcaccgac agccgggggc gcgacggctg
    15781 gctcgaccgg ctcggcgacc cgaacgggtt ctacggcctg gccggcgacc tgatcggcgg
    15841 gctgctgatc tggccggtgg cgggcttcgt gctgggcgcg ctgtggcgtc gtctgcccgg
    15901 cagacgcggc tacctcaagg gcgtcgtgcc ggtcctcgcg tacgccgcgg cgacgggcgc
    15961 gcacgccgtg ctgaacaacg tcatcggtca ggcccccgtg cgcggctcgc tcgtgcgggt
    16021 gctgctgctg ttcctggtgc tcaccgtcgt cgccgtcctc atggacgcgc ggaccctgca
    16081 gacccgcccg ggtggtctcg cgtcgcggct cacccccgtg gccgtcgtct accggctcgg
    16141 tacggcgggc agcggggtcg cgctcatcgt cgcgcaggcg gcggccatcc tcggcctgtg
    16201 gagccagctg aggaacggca tcgacatcac ttcacaggtg gacacctcca cccaggcgtc
    16261 gctccccgcc gacgcgcagc tgctccaggg acgtgcgggc gattagccgc cgatgccgac
    16321 ggaaaccgcg agggaagggc ggctccggcg cccggcgccg gagccgcggc acgtcctcag
    16381 agcgcggggt aggcgttgtt caccagcatc acgaactgct cgtggtgcca gtcgccgatc
    16441 agcggcgcgt tgggcagagc gccggtgggc cggaaaccgt ccgtaccggg ggtgagggag
    16501 ccgttggggt cgcatcggta gtcgatcagc cggtccgagc cctcgggcag gagcggcccg
    16561 ccgaccccgt ccgactcgcc cggccgcttg atccacaggt aggcgtcgac gccgggagcg
    16621 ggcgccgcga ccggccgggt ccccagcccc gcgccgttct ggttgcactc cgcgccccgc
    16681 gacggacgcc ggtcgacgcg gctctggtcc acgtacgtgt tgacgtcgcc ggaggtgctc
    16741 gcggccgtgg gccgggcggg cccgccccag ccgttgcggg aggtgtcgac gaccacgccg
    16801 agcgagccgg ggaagccctt ggcgatcagg gcggcgcgca tcgcgacggc gtagctccgt
    16861 tcgttcaggt aggggttcca gtcgatgaac ctgctctgga tgatcggctg gccgctcacg
    16921 gtctgatagg ggtcggtgag gaacggctcg tcgaggggga tgtagtcccc gacgttcgtg
    16981 gcgatgccgt cgaggccgtt gaggccgcgt gccgtgccgc gcacggtctc ggtgacgagg
    17041 gacgcgagcg ccgtgaagtt cgtctcccag ccggcccatc ccgcgctgcc cgcgtccaga
    17101 tacgtgtaga cgttgggcag gggcgccagc ttgtcgaggg cgtaccggat gcccatcacg
    17161 tagacgcccg accccgccgc ctgctcgcac gggtaggtgt ccaccgcgcc acccacgatg
    17221 aggtcgatca gggcccgcgg ttcgacgacg gccgcgacgc gcaggttccg gtactcgggc
    17281 ttggccagga gggcggcgat ggcgtcgacg tactcggtct tgtagcggtt gaggccgttc
    17341 tgctgctcgt gcagctcggc gtcggagacc cgcgaccggc agtcgcggtc cggcaggttg
    17401 tggagcacga gcgtgaggta tccggcccgc tgctcgacgg cggtgtcgag gtggtccttc
    17461 agcgtacggg cgaccccgga gccgccggtg acgtccgcga tccggtccag ccagaccgcg
    17521 gtggtggtcg tcttcaggcc gcgaatcctc tgcgcggtcg cgtcgtccac ccgcacggcg
    17581 gaggactcga cgtcggccgc ccagcccggg tcgacgtacc ccttgacgcc gacgaacggg
    17641 ttgtccaccg gcacgtccgg gctcgggctc ggcgacgggc tcggcgaggt gcccgccacc
    17701 tggcagggca cgccgttgac ggcgaagtcc gtgggcggcg ggttgctccc ggtccaggtg
    17761 ccgttgaagc cgatctggaa ggagccgccc gaggcgacgg gccggttcca cgactcgctc
    17821 ttggccgtga cccgggcgcc ggactggctc cactgggccg accagccctg cgtgacccgc
    17881 tgggagcccg ggaaggtgaa ggtcagggtc cagtccgtga gcggatcacc gctgttcttc
    17941 acggagacgg cggccgtgaa gccgcccgaa cccgttcccc actgggtgct cgtgtaggtc
    18001 acctggcacg tgaccgcggc gtcggcggac gtcgtgccca ggaccggtcc cgccacggcc
    18061 ggcgccgcgg cggggacgac cgccgcgacg accgtcagga tcctgcggac gaaacgatgg
    18121 tggccgaagg gcataggcga tcgtctccag gggcgtggtg acaggttccg gcatccggcg
    18181 cccgttgccg gttcacgcag gggcgccgac gctcccagac tcggcaatcg cccggctcgt
    18241 gtacacgaat cgccgaagtg gaaatgtccc tttccatggc agaaatgcgg gaaccgtatg
    18301 gcacctcgcg aaacgtcgta cgagatgcgc ggggcggcgc ctgaatgcgg tgaaatattc
    18361 agagccgccg gccgggccgg tccacgatgc cggaggcgag cagggcggtc gcccacaccg
    18421 accccgctcg gaacgcgggc gtggaatcac cctcgacgta ctcgtcgcgc acccacacca
    18481 tgcggctgcc gaggtagcgg taggtgcggg gatcgaggat gtggtagctc agggtgcccg
    18541 gatcagcacc ccagtcgaag cggatcccca ggccgcgccg tccggccgcg tccgcgacgt
    18601 ccttgtcgac cacgacatgg gggatcctca tcagcgcccg gaacatcgcg ccctccagct
    18661 tcggcggcat gaccacgtgc cgttcgaggt agaggaagat cacgcggaag gcccgcgcgt
    18721 ccgggggctc gacgttcttc ttcacgccct cctcgaccgg caggtcgatc cagtgccggt
    18781 cgccgctgac gtgggccagc aggtcgtccg ggtccgtggg gagccggcgc agcttcgcgt
    18841 cgtattgctg gggggacagg tcgtcgtcgc cgggatccgg cggcacgtcg ctgacgtgca
    18901 tccggccgtc ctctccgtag ccggcggtct gcttcccgtc gtagcggatc cagccttcct
    18961 gcgtcgtgcc ggaatcgtcg ttggcctgct tgtccagcgt cctggtgtag tgccactggt
    19021 ccggcctggg gacggcccgc cgcggccgcg actcggcgac ctcggccgcc tgccgcagca
    19081 cagtcgcgga gtcgagccgt acggtcgccg gccgcacgac gccgccgggc tcgtgcggcc
    19141 gggtcgcgat cacgacggac gcggcgccgc cgagggcccc ggcgagcagc agcctgcggc
    19201 cgaaccgggg gaggtgccag gcgcggacgc ggcgcagcag ccgcgccctg gccgggacca
    19261 gccactcggg acccgggtcc ggcacctcgg cgcgcatctc acggagcagt cgcaggtcat
    19321 ccatggagag gctcctcact tgtcgcgctg gggtcgtcgc cgccgagcgc cgcgcgggtc
    19381 ttcgcccgcg cccggtgtaa ccgcgatcgc acggtcccca ccggtatgtc cagggccctg
    19441 gcgacctcct cgtaggtgag gtcggcccac gcgaccagca gcagcacgtc acggtcgccc
    19501 gccgacagcc cggccagcgc cttcgccagg ccgcgctgcg cgctctgcgc ggacacccgc
    19561 tggttcacgc ggtcggcgta cggctcggcg acctcgtcca cccccgtcct caccagtgcc
    19621 cggtagaacc ggatctcggt acggcggtgc cgtccgatga ggttcgcggc gatgccgtac
    19681 agccacgggc gcgcgtccgg ctgggccggg tcgtagcgct cgcgcttgcg gaaagcggcc
    19741 aggaacgtgt cggagacgac gtcgtcggcg agggacgcgc ccaggcggcg ggcgacgtac
    19801 cggtgcagag cggaggcgtg ccggtcgaac aggtccgcga aggcctcggg gtcgcgccgg
    19861 gaccgctgga tcagctcggc gtcgtcgacg cgatcgggcg gtgcttcggg gatcacgtgg
    19921 gggctccatc catccggcta cccgctttca cccgacgaag ggaaaagagt tcgcggacgg
    19981 ttgaaagcct ttcccgcgcg aaggccggtt acgggcggtc gctgaaacag aggcagccgc
    20041 cgatctgggc cgccatctcc aactggtcgt agaacagccg gtgactgaga atcagccctt
    20101 cctccaccgt ggagaagctg cacgaacgta cgaggatggg ccgcccggtc ccctcgagaa
    20161 cgtccccgcc ggggacgaga agcggcccct tgtgcgtgcc gctgatcgtg aactccgccg
    20221 ccacggtgtc tccgaacatg gtcaccgact gcggcgtgat caccatgttg gggtacgcct
    20281 ccatccactg gccgtagtag gaggcgatct cctccctgct ctcggcgatg ccgtccgggg
    20341 ccacgagaac ggcccgctcg tcgaagcact gcgccagggc gtcgaggtca tggcggttga
    20401 tggcctgtct cagcctgtcc acggcacgga gcacttcgga catcggacgt tcccttcccc
    20461 cgacgagagc ggccgtatga tgcgcccgca ccgtgaccgg catgacagcg tccggacatg
    20521 ggcggcattt tcacgataac tcaggtcaaa tggctcttag tggaccgtgt gagccggtga
    20581 gggattcctt ccgtggtccc tctaccgggg tctgctgctc ccgttcgcgg gagtccggcc
    20641 agccgggcac gaccatcggc agcggctcgc cagaggatca gccgccgggc agggcacggg
    20701 cgtacgccga cgtgacggcc ggtgaagcgg cgcccgggcg gcgggccccc gcctgcccgg
    20761 gactgcgggt aaatcccatt gatccgtgag tgggccgatg gtttacggta tgcgcccgtg
    20821 tcttccatct gacccacctg gtcggtcccc accccggcgc atcgagtcag cggctggcct
    20881 ggctggcctc ccggtccgac ggcgtacccg ccggatcggc gtacctgcgc ctgtccaccg
    20941 ccgcgggaca cgagcatctc gccgagctcg acctgcacgt ccacccggcc gagcgccgcg
    21001 ccggggtggg gtcgcgcctg ctcgccgcgg ccctcgcgga gccgcatccc ggatatcggc
    21061 tggtctcctg ggagggcgtg gtcccggacg aactggccga gaccttcgcc gcgtcccgcc
    21121 gcgcgatgga cgac
//
