LOCUS       NZ_JABBXA010000006     23733 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H13382 NODE_6, whole genome shotgun sequence.
ACCESSION   NZ_JABBXA010000006
VERSION     NZ_JABBXA010000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H13382
  ORGANISM  Microbispora sp. H13382
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 381387)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 381387)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Antibiotics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014161445.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 07:22:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,906
            Genes (coding)                    :: 7,786
            CDSs (with protein)               :: 7,786
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 21 of 121
            Pseudo Genes (incomplete)         :: 104 of 121
            Pseudo Genes (internal stop)      :: 8 of 121
            Pseudo Genes (multiple problems)  :: 11 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:45:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6454
            Orig. end                         :: 30187
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBXA010000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23733
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23733
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23733
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13733](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13733
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(110..124)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            complement(684..1397)
                     /locus_tag="HHX41_RS14115"
     CDS             complement(684..1397)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133106.1"
                     /locus_tag="HHX41_RS14115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_310741983.1"
                     /transl_table=11
                     /translation="MLTVDFNRLPVGPGDRVLDLGAGGGRHAFEVLRRGADVVAFDMDA
                     AEMESVAAMFAAMDKEGEVPAGATGDTVVGDALDMPFPDASFDRVIAAEVLEHIPDDMA
                     AMREIVRVLKPGGRAAITVPSFLPERICWALSEDYHTAPGGHIRIYTLAELQAKLKASG
                     LDVGGHHYAHGLHSPYWWIKCAVGVNDDGHPLAKAYHELLVWDIMKRPLATRLAEAVLN
                     PLIGKSVVVYVRKPA"
     gene            complement(1429..2670)
                     /locus_tag="HHX41_RS14120"
     CDS             complement(1429..2670)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017610778.1"
                     /locus_tag="HHX41_RS14120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_182906345.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3.6e-32,
                     bitscore: 105.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAERLRVALLSYRSKPTCGGQGVYLRHISRELVALGHHVEVFSGQ
                     PYPELDEGVILNKVPSLDLYRDEDPFRTPKLDEYRDWIDALEVATMWTAGFPEPLTFSL
                     RAYRELKRRRGDFDVVQDNQTLGYGLLGIKKLLPVVGTIHHPISVDRRIELKAAKGWKR
                     LSMRRWYGFVRMQSIVAPRLSPILTVSESSLADIHRDFDVPQSNMRLIPLGVDTRFFHP
                     RPELPKRDNSIVAVASADSPMKGVATLLRAVAKLATEREVNLTVVSRPTPGGPTEQLVN
                     ELSLHDRVRFVHGIPDEELAELIATSDVAVVPSLYEGFSLPAVEHMACGTPLVASRTGA
                     LPEVVGDAAVQVTPGDPEELAAVLRRLLDSPEERAEFGRRGYERVMERYAWPVVARRTV
                     EAYHEAIAAHTPSR"
     gene            2926..3951
                     /locus_tag="HHX41_RS14125"
     CDS             2926..3951
                     /EC_number="4.2.1.47"
                     /GO_function="GO:0008446 - GDP-mannose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_function="GO:0070401 - NADP+ binding [Evidence IEA]"
                     /GO_process="GO:0019673 - GDP-mannose metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0042351 - 'de novo' GDP-L-fucose
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894608.1"
                     /locus_tag="HHX41_RS14125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="WP_182906346.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.6e-09, bitscore:
                     31.7, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARRALITGITGQDGSYLAEHLLSEGYEVWGLVRGQANPRVPRVR
                     RLLQDVRLVRGDLLDQGSLISAVEKVQPDEVYNLGAISFVPMSWEQAELTGEVTGMGVL
                     RVLEAIRVCSGITASRGSAAGQIRFYQASSSEMFGQVRETPQTERTPFHPRSPYGVAKA
                     YGHFLTQNYRESYGMFAVSGILFNHESPRRGAEFVTRKVSLGVARIKLGMAAELRLGNL
                     EARRDWGFAGDFVRAMHMMLSAAEPEDYVIGTGRIHSVRELVEAAFAAADLDWERYVVC
                     DAALHRPAEVDLLCADPKKARTQLGWEPTVSFEELVGMMVEADLRLLADGGDPEQDSSW
                     A"
     misc_feature    4027..4041
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            4110..5336
                     /locus_tag="HHX41_RS14130"
     CDS             4110..5336
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545919.1"
                     /locus_tag="HHX41_RS14130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_220504057.1"
                     /transl_table=11
                     /translation="MAVPGPGSSARRGHERAVLGLLRAHGPLNRGELGRRCGLSRTTLH
                     EALSGLLAAGAVVTAAPDDGPRGRGRPAGKLALNTAVGQAVGIDFARRAVHVAAVDVTY
                     EVLGTAGEAHAPGLPWPDRVALAERLVRRVVGGEPWLRALRGVGVGLVGPVAGAAAVAG
                     VESLLRDRFGGPVLLDNNTRLAALAESTWGAAAGAQDVLYLRLSYGVGGGVVAGGALHR
                     GADGVSGEIGHIPVDPEGRRCECGGTGCLETVASIRAVLDAYRARGGRGDSLPALMAAV
                     EAGDPLALGLLRDVGVQIGRVLAALSNAIGPRVIAIGGELAEIGAPLLGPVQEALHAGA
                     VPISRHRLTLRRAALGDVAGALGGVALAMGESPLLSRYAAAEPETGPAGSRAGRYGAVA
                     AGRRLALTG"
     gene            complement(5364..6563)
                     /locus_tag="HHX41_RS14135"
     CDS             complement(5364..6563)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894598.1"
                     /locus_tag="HHX41_RS14135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_182906348.1"
                     /sec_met_domain="p450 (E-value: 1.6e-15, bitscore: 51.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEINLVDKDLYTRSGVPHEQLRWLRANAPVYWHEGQDDWPGFWAI
                     TKHADVVHVSRHSDLFSSARKLALFDEMPEEQRELQRLMMLNQDPPDHTRRRSLVNRGF
                     TPRQIGRLEEHIRDICHALVDEVRDKPEVDFVRDIAAPLPLYVICELLGAPVEDRDKIF
                     EWSNRMIGSDDPDYSTSPEEGQAAALEVYSYAHTLAEARRQEPRDDIVTKLLQPDEDGQ
                     TLTEDEFDLFVLLLIVAGNETTRNAASGGMLTLFEHPDQWKRLVDDPSLARTAADEIVR
                     WVSPVNLFRRTATADSEIRGQKIAEGDKVVVFYASANRDADVFERPDEFDIGRDPNPQI
                     GFGGGGAHFCLGNHLAKLELRVLFEVLAQRLPGIRQAGEAKRLRSNFINGIKTLPVTLG
                     "
     misc_feature    complement(6543..6557)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    complement(6549..6564)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.24"
                     /tool="antismash"
     misc_feature    complement(6699..6714)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(6731..9565)
                     /locus_tag="HHX41_RS14140"
     CDS             complement(6731..9565)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.5"
                     /locus_tag="HHX41_RS14140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_182906349.1"
                     /transl_table=11
                     /translation="MASGRPVLLHRDKELEVVDDVLAGLSDGRPAVLVIQGTRGIGKTR
                     LLHAALARRPGGVVLSARGHADERSFAFGIVRQLFDPMMSGSGRAAELGVPAAVLEANV
                     HAPAMTAVAYDGSAPGVPATLLDDLYRATRSLTAGQPLIIAVDDLNHADPQSAQWCSYI
                     ARRLDGLPIAMILTCDADDRSAGETVRDILALPYARSLRPSALCRKCAATLVESALGAS
                     VDDEIVSACHRLTKGNPLLLLETAARLAAADVLPDRSELPRVQRIGAIALSETVLEWLG
                     GRYPSILTLLQSLAIIAPYAGLETAAMLAGYGAVAAEEAGQALAGAGLLEGSPPQRFTH
                     DLVQSTILARMDPRARDELHRRAASLLHRLGSPPKRSARHLLSASPTGDPWAVSVLREA
                     AREAVSENAWEDATRYLHRALATAKGQTVLQVTAELGAVVVHLDIPACLRHFRTVTALA
                     DGVGERADSLAPFATTLLTLNSPEAASAFCDVARGLDDDPDGRLPDRREVLLRLSAQAL
                     LTGQSYGSRAAMRHLGTGTSAGAQDYLATAALSGAARGKHRERTLALARRCLDGGGPIP
                     PTLVIALLWAGRVDEAAYWSEQVAADARAHASVTGQALAVTLLSDVAYRRGELRASLAH
                     AREAILFARASHAFGLHAAAVSCAARALLERDELDVAHALFDEVAAREPVHPFLHGALL
                     EAQGRVSIARGDVREGLRALLEAGRQLLSAGVVNPACGGWRGQAALAYMRLGQRVTARR
                     LAEEELELARAWGAPYGIGRALSTMSATAEGDRRLDLLTEALTVLDGAEGGMERLRAMV
                     RMGIALQAAGDARRAHDMLSEAYALADGRGAVRLAALAERSLAGTGGRPRGGHAGGPSP
                     LTAGEMRVTDLVLRGLSNLQVATELSISKRTVDTHLARIYRKLGIHTRAELAEIVKRLR
                     ERHAGTGRWPGQEE"
     misc_feature    9589..9603
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.38"
                     /tool="antismash"
     misc_feature    9645..9660
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.15"
                     /tool="antismash"
     gene            10001..12256
                     /locus_tag="HHX41_RS14145"
     CDS             10001..12256
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Goadsporin_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="HHX41_RS14145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_182906350.1"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 1.7e-18, bitscore:
                     61.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 4.6e-13,
                     bitscore: 43.6, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 1.5e-13,
                     bitscore: 45.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 1.8e-89, bitscore: 295.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 6.4e-78, bitscore:
                     256.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERPRLKAHFTTEVLDDAKVFLLAEGQHYLVRGAGSGRVLPYLDG
                     RHTVMDIVQALAGELSPAQAVLAIRRYEAAGHLVEGRPALTDPVLAFWDAQGIDPAAVV
                     TALEQTSFRVFAGTGVDPGPVEALLREHGLRTDPHGDGMVVAVVDDYLDPGLEELNAEC
                     LAAGRPWVLVRPAGTVAWLGPLFQPGDTGCWACMSQRLEGNRQVERYLAGKRGGGRPTH
                     PVREALPGGVAAVGGLLAAELVRTAATGEPSTLQGKMITVDLRTLTTAEHQLIRLPQCP
                     VCGDPSLIREREPKVALASRTARHVTDGGYRVEQPSATYARLERHVSPYLGAVTGLRPW
                     TGEDNGVTYSYTAGHNFAMLGDNMDLLRRNLRGQSGGKGRTEVQAKVSALCEAIERYSG
                     VWRGEEPVLKAAYADIGEGLAVHPDDLLLFSDKQYGDRSAWNSDPSHRLHLVPERFRTD
                     LPLDWSRAWSLTADEERLIPAGYAWYGHPDLERHFYCVGDSNGSASGNTLEEAILQGFC
                     EVVERDAVALWWYNRARRPAFDLDSLNEPYVDTLREFYADMGRSLWLLDLTTDLGVPAF
                     AGVSHRLDHPVQDIIVGFGAHLDPRIAALRTLTEVNQFLPSVRRRDENGETIYHDDDIA
                     TLRWWKGTTIESDPWLLPDPAQRPRTLADHVVPQDTDLAADVETCVARAAACGLEMIVL
                     DQTRPDLELNVARVLVPGMRHFWRRLGPGRLYDVPVALGWRTQPATEEELNPTSVFF"
     aSDomain        10004..10282
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHX41_RS14145_NHLP_CD_RRE.1"
                     /evalue="1.30E-19"
                     /identifier="RREFam015.1"
                     /label="HHX41_RS14145"
                     /locus_tag="HHX41_RS14145"
                     /protein_end="94"
                     /protein_start="1"
                     /score="61.0"
                     /tool="antismash"
                     /translation="ERPRLKAHFTTEVLDDAKVFLLAEGQHYLVRGAGSGRVLPYLDGR
                     HTVMDIVQALAGELSPAQAVLAIRRYEAAGHLVEGRPALTDPVLAFWD"
     aSDomain        10013..10234
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHX41_RS14145_Cyanobactin_D_RRE.1"
                     /evalue="3.60E-14"
                     /identifier="RREFam007.1"
                     /label="HHX41_RS14145"
                     /locus_tag="HHX41_RS14145"
                     /protein_end="78"
                     /protein_start="4"
                     /score="43.6"
                     /tool="antismash"
                     /translation="RLKAHFTTEVLDDAKVFLLAEGQHYLVRGAGSGRVLPYLDGRHTV
                     MDIVQALAGELSPAQAVLAIRRYEAAGHL"
     aSDomain        10013..10294
                     /aSDomain="Goadsporin_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     goadsporin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HHX41_RS14145_Goadsporin_CD_RRE.1"
                     /evalue="1.20E-14"
                     /identifier="RREFam013.1"
                     /label="HHX41_RS14145"
                     /locus_tag="HHX41_RS14145"
                     /protein_end="98"
                     /protein_start="4"
                     /score="45.2"
                     /tool="antismash"
                     /translation="RLKAHFTTEVLDDAKVFLLAEGQHYLVRGAGSGRVLPYLDGRHTV
                     MDIVQALAGELSPAQAVLAIRRYEAAGHLVEGRPALTDPVLAFWDAQGI"
     gene            12273..13733
                     /locus_tag="HHX41_RS14150"
     CDS             12273..13733
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.5"
                     /locus_tag="HHX41_RS14150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_182906351.1"
                     /sec_met_domain="PF00881 (E-value: 9.3e-18, bitscore: 59.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTVEVRLRRDAGLSEPGETPGAVTLTTPFGPAALRGLPAGAVAA
                     LRVLAGGGASEEELAGIVTGHDGEGGLLRWHMLLRKLSAGALLERAVAPSGGEPVAVLR
                     PYGGGPLRPAAPLAADTRVRLSRFAVAGPEDGRLVVRAPRSPLGVELAPAAAPLLGLLA
                     DWTTPAALACPGLPAGTTAAVLGLFADAGLLVRPTPEGEDPERGAAPLAQWSPADLWLH
                     TRTREPRTTGRYGGTYPLKGVWDPLPATPPAFPGPRIALEPPDLDAIAKTEAGLTEVLE
                     GRRSIREHDAAAPITLDHLGELLYRTMRQRRTFTGEDGQELADRPYPSGGAVHELEVYP
                     LVVSCEGLEPGLWHYAADAHALERVADPGPATRILLDRARSAAMMTEDPQVLLIVTARF
                     GRVMWKYETIAYSLILKHVGVLYQTFYLVATAMGLAVCGLGGGDAAEFAAASGLDPHAE
                     GSVGELLLGSRPGAAAGTPPRWPTGGPA"
     gene            13730..14542
                     /locus_tag="HHX41_RS14155"
     CDS             13730..14542
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012584.5"
                     /locus_tag="HHX41_RS14155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="biotin/lipoyl-containing protein"
                     /protein_id="WP_182906352.1"
                     /transl_table=11
                     /translation="MKFRLKALQRMREPDELDSPTLLASPRGWIATFVVLIVVVAAGAW
                     SFVGRLPVTVTAKGLLTRPAGTAELQSPYTGTVRTMMVSPGLRVVRGQAVAEVLRADGT
                     VRTVSSPFAGEVVTTSASVGAMVREGDGLLAMERTDDPHDRLVAMLFVPGDHALGIAPG
                     RMVDLAVADAPPGVFGLLRGKVTSISPYPLMAEGVAGLVGGDLAARGYVTAQPPRLVVV
                     DLLPDAATPSGYSWTTETGPPTKLRSQVTVTGTVTLSSQTPFNLLLGR"
     gene            14554..16806
                     /locus_tag="HHX41_RS14160"
     CDS             14554..16806
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR03796.1"
                     /locus_tag="HHX41_RS14160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_182906353.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.2e-35, bitscore:
                     116.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQVTAPRADAQPPRAPRRRAHPRRGGRRGSTPTVIQMEAVECGA
                     AALAMILGHYGKFVPLEELRAACAVSRDGAKASSVIAAARKYGLEAKGFQMELDDLRDV
                     VKPAIIFWAFQHFMVVEGIRTRFGRQAVAVNDPASGPRLLDWDEFDSGFTGIVLTFEPG
                     PGFRPGGRPTRVAEALLSRRMPTGRALPLVLLASLLLVVPGIIAPAFSRVFIDHILTGR
                     SPGFILPLLLAMSMTALAMFVLTSVQRHYLLRMEIRMGLVSSARFFRHLLRLPVEFFLQ
                     RRPAEVSRRVSANDTVAEILSRDLAITVVNLVLVLFYAVVLIRYDLLLGLIGVGMALLN
                     IVVLRQVSRARTDAVAALRADLGNLTSATFNTLQLVETVKATGAEPGAFQRWAGFLAKA
                     VTARQRLGVPSAVITVVPPLLAGVNSGLILLVGGLRVVDGAVSVGLLVAFQSLLGALSR
                     PVTQLTNLGGRLQYISADITRLYDVERHPRSPVFDREDRPLGSRLDGSITFDEVTFGYN
                     PLAKPVIRQVSFSVVPGRRVAIVGSSGSGKSTIGRLAAGLYGPTSGRVLLDGRDRQEIS
                     RTELAASIAYVDQDISLFEGTVRDNLTLWSDDVSDEVVTAALHDAAIFDVISARPGGLN
                     SGVREGGRNFSGGQRQRMELARALAAQPTLLVLDEATSALDPETERVIADNLRRRGCAC
                     LIIAHRLSTVRDADEILVLHEGEVVERGIHEDLVRLGGHYARLIENARTGGEGADQ"
     gene            16803..19778
                     /locus_tag="HHX41_RS14165"
     CDS             16803..19778
                     /GO_function="GO:0015440 - ABC-type peptide transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0043213 - bacteriocin transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR03797.1"
                     /locus_tag="HHX41_RS14165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NHLP bacteriocin export ABC transporter
                     permease/ATPase subunit"
                     /protein_id="WP_182906354.1"
                     /transl_table=11
                     /translation="MSVSTVAESPAFSSFFTDAATPVDYSADRLLVLADLREVLLVEHG
                     AVDLFAVRLENGRPVGRWNYLCRVRQGTLMLGSPRGPRHSIVGRPVLGTRVSRLPLARL
                     EGLSARRVHGPSRSGKAVRALSTREYGLAVGEFVRGLDAGVVALAASIRDTLPPRDFVP
                     LVPHEPVVVREGEAVRSVDGVQWITVEDGVVEMPEGVAGQLSAGAEVCVTERDWLVALG
                     PARLRARSTLDLLGEGALWHRWVEYTTRFLYTIDRRVERRNSAELKVLTSRAERGGDVL
                     RTTARGFDTLVRDTEARVRLADVAGDPPALAAARLVASHAGFSVTAPPQGGAHGGRIDP
                     LQAIALASGVRTRRIRLDDRWWRRDIGPMVGYLTSDGAPVALLPIGSRYVMAAPGEERV
                     TPVTAAVAGTLTRHADVLYEPLPPTVAGVGGLLRFGLAKNRKDLWTLLSLGTLVAVIGL
                     LVPAMTGLVLGTYVARAEREMIVQGALLVIAGSLVAAALSVVQNFAALRIEGRSSSRLQ
                     AGAWMRLLSLPATFFTNYSTAELGTTVLGVSAVQETLSGVMTTAALGLFAGLANLVLVY
                     FYDVGLALIATALVLAGVLVCAVAGCFEVRLQRRLYTHEQRLSSRVFQLLTAVPKLRVA
                     AAEDRAFGVWASQFLRARSIGVSARRVQNFVTTFNAGFPLVASVIVFAVVAGPMLGQVA
                     VPAFLAFFAAFNLLLASVLQFTGAAITAMSVVPMLERMRPILAAEPEEHTGKADPGELS
                     GRIELSRVSFRYGEDGPLVLDEVDVSIEPGEFVAVVGPTGSGKSTILRLLLGFESPSSG
                     TVLYDGQDLGELDIGAVRRQCGVVLQNSALLAGDIKTNIIGSTDHTTDDAWDAAGMAGI
                     ADDIANMPMGMHTVLSEGTNTLSGGQRQRIMIARALVSHPRIVLFDEATSALDNPTQKI
                     VTESTRQLNATRVVIAHRLSTIRDADRIVVLDRGRVVQQGRYHELLEDAGGLFARLARR
                     QI"
     gene            complement(19850..20035)
                     /locus_tag="HHX41_RS14170"
     CDS             complement(19850..20035)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS14170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_169984297.1"
                     /transl_table=11
                     /translation="MSPFWKIFLAIFCYISGLVGLGLAIANASVKPPATTHAFVYGGLG
                     VVFLIAGIAMSRKPRY"
     gene            complement(20032..20874)
                     /locus_tag="HHX41_RS14175"
     CDS             complement(20032..20874)
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="HHX41_RS14175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_169984296.1"
                     /transl_table=11
                     /translation="MSGASGVSAGSYDPATTTAGGLSGELARLEAQAELSFDEELRVLL
                     DVGVPAPLLELGAGSGAVTRRLRAALPDLPIVAADIDTALLAHAADARVPLMGCDAVRL
                     PLADGVVGTVLLRYVLQHVADPAAVVAEALRVLRPGGRLVVIEVDSMLWGLADPMYPEL
                     AGVHGRMAGAQRQAGGDRLIGRKLTRILRRAGFREVVLRPFATTNDDRPTEAFAPHMGP
                     ERLAPLVASGALSLPELALAADRWRRFRADPDAWVMLLGLVVAGTAPGGPAESERSTS"
     gene            complement(20871..22121)
                     /locus_tag="HHX41_RS14180"
     CDS             complement(20871..22121)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="HHX41_RS14180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_182906355.1"
                     /sec_met_domain="p450 (E-value: 2.8e-79, bitscore: 261.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREAPLRFVTEMAAYGDVTRHETETGPVYMLHRPDLARHVLKDNG
                     ANYTKDRTPDDDMLRPLLGNGLLTSGGEEWARQRKMIAPAFRPTEVERFDQIMTDAAAG
                     LTERWRRAGEEGAAVRVDHDLTSLTLTVLARAMLGADIAGVGDGFGRAVDEVNRFIGHF
                     DPASEGGGREGFRRAKAFLDGVTRAIVAARRATGQEGDDLLGAMLASGHAMTATDLRDQ
                     VLTIVMAGHETTAKALTWTLYLLDRHPDVARAVRAEVDEVLGGDRTATAADLPRLAACQ
                     RAIKEAMRLYPPVWLISRRSVEADVVGGYPIPPGTLVCVSPYVLHRDPRYWHDPETYAP
                     DRFTAEHTHAGHQYLPFGGGPRVCVGRHFAMVEATLVLAVLLRGVRPELVPGFPVEPEA
                     LVTLRPRHGMLMVPRPR"
     misc_feature    22201..22214
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.01"
                     /tool="antismash"
     misc_feature    22201..22215
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.32"
                     /tool="antismash"
     misc_feature    complement(22210..22223)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.87"
                     /tool="antismash"
     misc_feature    complement(22398..22413)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            22421..22813
                     /locus_tag="HHX41_RS14185"
     CDS             22421..22813
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS14185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_211592441.1"
                     /transl_table=11
                     /translation="MSLDPRQRAEFVNAYTRVLITAWSSEEYSARLDSDPRSALAESGL
                     ELPAGAEVVLVRNIPEGHHDSNIDVQVALWERGLETGRFELHIPETPQVDMAELSEGDL
                     DSIAAGASAQEAIDINCCCCPCCCCT"
     misc_feature    complement(23191..23205)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 gcgccggacc gccgccgcgc cgcgtacggc gccgccgagc acggggtagt accagtccat
       61 cgagaaccgg ctcttgtcgg cgaacgcctc cgggtggtcg gcgatcacgt ggccgagctg
      121 gtcggcggcg agctcccagt cgggctgcgg gtcgcccagc cgttcggcga gcagcgcccc
      181 gcaccgcagg ccctggtaaa tggaggagga tccggtgagc agggcgtact ccgccggacg
      241 gccctcggcg tcgcgctgcc acagcacctc gccgcgcgcg gtctgcaggc cgatgacgaa
      301 gtcgagggcc cgggtcaccg ccggccacat cgaccgggcg aagtcctcgt cgccggtcac
      361 cagcaggtcg tgccagaccc ccaccgcgat gtacgccgca tggttggact ccccggccgc
      421 ctcggcgggc tcgccgtcgc gcaccttcat cggccaggag ccgtccggtc gctggtgccg
      481 tacgagccag tcgtagccct tgcgggcctc ctcgcgcagc ccggcgacgg tcagcgccat
      541 caggcactcg atgtggttcc acgcgtcgat gtggccctcg ggccagggca cgccaccctg
      601 ctcgtcctgg atcgcggcga tgctctcggc cgtacggacg acctgctctg gggtgatgat
      661 tcccgaaacg tccggcagcc gcctcatgcg ggcttccgga cgtagaccac cacgctcttg
      721 ccgatcaggg ggttgagcac ggcctcggcc agccgggtgg cgagggggcg cttcatgatg
      781 tcccagacga gaagctcgtg gtaggccttg gccagcgggt gcccgtcgtc gttcaccccg
      841 accgcgcact tgatccacca gtacggcgag tgcaggccgt gggcgtagtg gtggccgccg
      901 acatcgagcc cggaggcctt cagcttcgcc tggagctccg ccaacgtata aatccggata
      961 tgtccgccgg gggccgtgtg gtagtcctcc gacagggccc agcagatccg ctcgggcagg
     1021 aaactcggca ccgtgatcgc ggcccggccg cccggcttca gcacgcgtac gatctcgcgc
     1081 atcgcggcca tgtcgtcggg gatgtgctcc agcacctcgg cggcgatgac gcggtcgaac
     1141 gacgcgtcgg ggaacggcat gtcgagggcg tcgccgacca cggtgtcgcc ggtcgcgccc
     1201 gccggcacct cgccctcctt gtccatggcc gcgaacatgg ccgccacgct ctccatctcg
     1261 gcggcgtcca tgtcgaaggc gaccacgtcg gcgccccggc gcagcacctc gaaggcgtgc
     1321 cggccaccac cggccccgag gtcgaggaca cggtcgcccg gtccgacggg cagccggttg
     1381 aagtcgacgg tcagcactcg ctgcctgcct ttcgtcagtt ctggggagtc accgcgaggg
     1441 ggtgtgggcg gcgatggcct cgtggtaggc ctcgaccgtg cggcgggcga ccaccggcca
     1501 cgcgtagcgc tccatgacgc gctcgtagcc gcgccggccg aactcggcgc gctcctcggg
     1561 ggagtcgagc aggcggcgca gcacggcggc cagctcctcg gggtcgcccg gcgtcacctg
     1621 cacggccgcg tcgccgacca cctcgggcag ggcgcccgta cgcgaggcga ccagcggcgt
     1681 gccgcacgcc atgtgctcga cggccggcag cgagaacccc tcgtacagcg aggggaccac
     1741 cgcgacgtcg gaggtggcga tgagctcggc cagctcctcg tcggggatgc cgtgcacgaa
     1801 ccgtacgcgg tcgtgcaggg acagctcgtt gacgagctgt tccgtgggcc ctccgggggt
     1861 gggcctgctc acgacggtga ggttgacctc tcgctcggtg gcgagcttgg cgaccgcccg
     1921 cagcagggtc gccacgccct tcatgggcga gtcggcgctg gccacggcga cgatcgagtt
     1981 gtcccgcttc ggcagttccg gccgggggtg gaagaaccgc gtgtcgaccc cgagcgggat
     2041 cagccgcatg ttggactgcg gcacgtcgaa gtcgcggtgg atgtcggcca gcgacgactc
     2101 gctgaccgtc aggatcgggc tgagccgtgg cgccacgatg ctctgcatgc gcacgaagcc
     2161 gtaccagcgg cgcatcgaca gccgcttcca gcccttggcg gccttcagct cgatccgccg
     2221 gtccacgctg atcgggtggt ggatcgtgcc gaccacgggg agcagcttct tgatgccgag
     2281 caggccgtag cccagcgtct ggttgtcctg gacgacgtcg aagtcgcccc gccgcctctt
     2341 cagctcgcgg taggcccgca ggctgaacgt cagcggctcg gggaagccgg ccgtccacat
     2401 cgtggcgacc tcgagcgcgt cgatccagtc gcggtattcg tcgagcttcg gcgtgcggaa
     2461 cgggtcctcg tcgcggtaga ggtccaggct cggcaccttg ttgaggatca cgccctcgtc
     2521 cagctccggg tacggctggc ccgagaagac ctcgacgtgg tggcccagag cgacgagctc
     2581 gcggctgatg tggcgcaggt acaccccctg gccgccgcag gtgggcttgc tgcggtagga
     2641 cagcagcgcg actcgcagcc tctccgccaa gaggcacccc tttccagccg gtttcccgcc
     2701 gtgccccgtg gggctgctgc caggaacact accatttgac cttagatggg gtaggtgagg
     2761 tggaaagggt cctcgatcga ctgtcaccct gcccgacctg gggtgttagc ttacccgaac
     2821 gagattcggt gtaacacgtt ctagcggcgc atatgtagga cgtggccggg cagggcggta
     2881 cattcgcctc tcataggcca agttgggcgc tacgaggagg atccgttggc caggcgtgcg
     2941 ctgatcaccg gcatcaccgg tcaggacggc tcctatctcg cggaacacct gctgagcgag
     3001 ggatacgagg tctggggcct ggtccggggg caggccaacc cccgcgtccc gcgggtgcgc
     3061 cggctcctgc aggacgtacg gctggtccgc ggcgacctgc tcgaccaggg gtcgctgatc
     3121 tcggccgtgg agaaggtgca gccggacgag gtctacaacc tgggcgccat ctcgttcgtg
     3181 ccgatgtcgt gggagcaggc cgagctgacc ggcgaggtga ccggcatggg cgtgctccgc
     3241 gtgctcgagg ccatccgcgt ctgctcgggg atcaccgcct cgcggggctc ggcggccggg
     3301 cagatccgct tctaccaggc gtcgtcctcg gagatgttcg gccaggtcag ggagacgccg
     3361 cagaccgagc gcaccccctt ccaccccagg tcgccgtacg gcgtggccaa ggcgtacggg
     3421 cacttcctca cgcagaacta ccgcgagtcg tacgggatgt tcgcggtgtc ggggatcctg
     3481 ttcaaccacg agtcgccccg gcggggggcc gagttcgtca cccgcaaggt ctcgctcggc
     3541 gtcgcgcgga tcaagctcgg catggccgcg gaactgcgcc tgggcaacct ggaggcgcgc
     3601 cgcgactggg gattcgccgg cgacttcgtc cgcgccatgc acatgatgct gtcggccgcc
     3661 gagcccgagg actacgtcat cggcaccggg cgcatccact cggtgcgcga actggtcgag
     3721 gcggcgttcg ccgccgccga tctggactgg gagcggtacg tcgtctgcga cgcggccctg
     3781 caccgcccgg cggaggtcga cctgctgtgc gcggacccga agaaggcccg cacgcagctc
     3841 ggctgggagc cgacggtgtc gttcgaggag ctcgtgggga tgatggtcga ggccgacctg
     3901 cgcctgctcg ccgacggcgg cgaccccgag caggactcct cctgggcctg acatccccct
     3961 tgcgggccgc gggcctggcc tcggccgtcc aggattgaca caaaacctac caactgtgca
     4021 tgctttatcg catgtggcga tcggacggtg ctgcgtctcc tgacccggcg tctcctggct
     4081 tggcgtctcc tggcttggcg tctcctggct tggcggtccc cggtccggga tcctcggcgc
     4141 ggcgcgggca cgagcgggcc gtgctcggcc tgctgcgcgc gcacggtccg ctgaaccggg
     4201 gcgaactcgg ccggcggtgc ggcctgtcgc gcacgaccct gcacgaggct ctcagcgggc
     4261 tgctggccgc gggcgcggtg gtcacggcgg cgccggacga cgggccgcgc ggcaggggcc
     4321 gccccgccgg gaaactggcc ctcaacaccg cggtgggcca ggccgtcggc atcgacttcg
     4381 cccgtcgcgc ggtgcacgtc gcggccgtgg acgtgacgta cgaggtcctg ggcacggcgg
     4441 gggaggccca cgcgcccggc ctgccgtggc cggaccgggt ggcgctcgcc gagcggctcg
     4501 tccggagggt cgtcggcggc gagccatggc tcagggcgct caggggcgtc ggcgtgggcc
     4561 tggtgggccc ggtggccggg gcggcagcgg tggccggcgt cgagtccctc ctccgggacc
     4621 gcttcggcgg gccggtgctg ctggacaaca acaccaggct cgcggcgctc gccgagtcga
     4681 cgtggggcgc ggccgccggc gcccaggacg tgctctatct gcgactgtcg tacggagtcg
     4741 gcggcggggt ggtggcagga ggggcgctgc accgcggtgc cgacggggtg tccggggaga
     4801 tcgggcacat cccggtggac ccggagggaa ggcgctgcga gtgcggcggc acgggatgcc
     4861 tggagaccgt cgcctcgatc agggcggtgc tcgacgcgta ccgtgcccgg ggcggacgcg
     4921 gcgacagcct gcccgcgctg atggccgccg tggaggcggg cgacccgctc gccctgggcc
     4981 tgctgcgcga cgtcggcgtc cagatcgggc gggtgctcgc cgcgttgtcc aacgcgatcg
     5041 ggcccagggt gatcgccatc ggcggggaac tggccgagat cggtgctccg ctcctggggc
     5101 ccgtgcaaga ggccctgcac gcgggcgcgg tgccgatctc gcgccaccgg ctgaccctgc
     5161 gccgggcggc gctcggcgac gtcgcgggcg ccctcggcgg cgtcgcgctg gcgatggggg
     5221 agtctccgct gctgtcgcgc tacgcggccg ccgagccgga gaccggcccc gcgggctcgc
     5281 gcgccggccg gtacggcgcg gtcgcggccg ggcgacgcct ggcgctgacc ggctgaccac
     5341 gccgccggcg gctgtggcgc ccgtcagccg agggtgacgg gcagcgtctt gatgccgttg
     5401 atgaagttgg acctcagccg cttggcctcg ccggcctgcc ggatgccggg caggcgctgg
     5461 gccagcacct cgaacagcac ccgaagctcc agcttggcca ggtggttgcc gaggcagaag
     5521 tgcgccccgc ccccgccgaa cccgatctgg gggttgggat cgcggccgat gtcgaactcg
     5581 tcgggccgct cgaacacgtc ggcgtcccgg ttggccgacg cgtagaagac caccaccttg
     5641 tcgccctcgg cgatcttctg gccgcggatc tcgctgtccg cggtggccgt acgccggaac
     5701 aggttgaccg gggacaccca gcggacgatc tcgtcggcgg ccgtcctggc gagggagggg
     5761 tcgtccacca ggcgcttcca ctggtccgga tgctcgaaga gggtcagcat gccgccggac
     5821 gccgcgttcc tggtggtctc gttgcccgcc acgatgagca gcaggacgaa caggtcgaac
     5881 tcgtcctcgg tcagcgtctg cccgtcctcg tcgggctgca gcagcttggt gacgatgtcg
     5941 tcgcggggct cctgcctgcg tgcctcggcg agggtgtggg cgtacgagta gacctcgagg
     6001 gcggcggcct gcccctcctc cgggctggtg gagtagtcgg ggtcgtcgct gccgatcatg
     6061 cggttggacc actcgaagat cttgtcccgg tcctcgaccg gcgcgccgag cagctcgcag
     6121 atcacgtaca gcgggagcgg cgcggcgatg tcccgcacga agtcgacctc gggcttgtcc
     6181 cggacctcgt ccaccagcgc gtggcagatg tcgcggatgt gctcctccag ccgcccgatc
     6241 tggcgcgggg tgaaaccccg gttgaccagc gagcggcgcc gggtgtggtc gggcgggtcc
     6301 tggttgagca tcatcaggcg ctggagctcg cgttgctcct cgggcatctc gtcgaacagc
     6361 gccagcttgc gggccgagga gaacagatcg gaatggcggg agacgtggac gacgtccgcg
     6421 tgcttggtga tcgcccagaa tccgggccag tcgtcctgcc cctcgtgcca gtagacgggc
     6481 gcgttggccc tgagccagcg gagctgctcg tgcgggaccc cgctgcgcgt gtaaaggtcc
     6541 ttgtcgacga ggttgatttc catgcatcca cctaatcggg ttcggctgcc cttggtaaga
     6601 gggatgatcg ccctgtcggc gcggtacgtg tggtcgacgc ctgctcgacc tgaaatcgat
     6661 ctgaaacgtg ttctagtacg cgtgcgacgg cccgtcaagg gacccggagg tgacggagcg
     6721 ctggcgcgtc ctattcctcc tggccgggcc accggcccgt gccggcgtgg cgttcgcgca
     6781 gccgtttgac gatctccgcc agctcggcac gggtgtggat gccgagcttg cggtagatgc
     6841 gggccaggtg ggtgtccacg gtccgcttgc tgatggacag ctccgtcgcg acctggaggt
     6901 tgctcaagcc gcgcaggacc aggtcggtga cccgcatctc cccggccgtc agcggtgacg
     6961 ggccaccggc atgcccgccg cggggccgtc cgccggtgcc ggcgaggctg cgctcggcga
     7021 gcgcggcgag tcgcacggcg ccgcggccgt cggcgagcgc gtacgcctcg ctgagcatgt
     7081 cgtgggcccg gcgcgcatcc ccggcggcct gcagggcgat gcccatgcgc accatcgcgc
     7141 ggaggcgttc catgccgccc tcggccccgt cgagcacggt cagcgcctcg gtgagcaggt
     7201 cgaggcggcg atcaccctcg gcggtcgcgc tcatggtgct cagcgcgcgg ccgatgccgt
     7261 agggggcgcc ccaggcccgg gccagctcca gttcctcctc ggccaggcgg cgggcggtca
     7321 cgcgctggcc gagccgcatg taggccagcg ccgcctggcc gcgccagccc ccgcaggccg
     7381 ggttgaccac cccggccgac agcagctgcc gcccggcctc cagcagggcc cgcagcccct
     7441 cgcgtacgtc acccctggcg atcgagaccc ggccctgggc ctccagcagg gctccgtgca
     7501 ggaagggatg caccggctcg cgtgcggcga cctcgtcgaa cagcgcgtgt gcgacgtcga
     7561 gttcgtcgcg ctcgaggagc gcgcgggccg cgcaggacac cgcggcggcg tgcagtccga
     7621 aggcgtgcga cgcccgcgcg aagaggatgg cctcacgcgc gtgcgccagc gacgcgcgca
     7681 gctcccccct gcggtaggcg acgtccgaca gcagcgtgac ggcgagggcc tgcccggtca
     7741 ccgaggcgtg cgcccgcgcg tcggcggcca cctgctccga ccagtacgcc gcctcgtcca
     7801 cgcggcccgc ccacaacagc gcgatgacca gcgtcggcgg gatcggcccg cccccgtcga
     7861 ggcagcgccg ggccagggcc agggtgcgct cgcggtgctt tcccctggcc gcgccggaca
     7921 gcgcggcggt ggcgaggtag tcctgtgctc cggcgctggt gccggtgccg aggtggcgca
     7981 tcgccgcgcg tgagccgtac gactggccgg tgagcagcgc ctgcgcgctg agcctcagca
     8041 gcacctcgcg gcggtcggga agccggccgt ccgggtcgtc gtcgagaccg cgggcgacgt
     8101 cgcagaaggc cgaggcggcc tccggggagt tgagcgtgag cagggtggtg gcgaagggag
     8161 ccagggagtc ggcccgctcg ccgacgccgt cggcgagtgc ggtcacggtg cggaagtgcc
     8221 gcaggcaggc ggggatgtcg aggtgcacca cgacggcgcc cagctcggcg gtcacctgga
     8281 gaacggtctg gcccttggcc gtggcgagtg cccggtggag gtagcgggtc gcgtcctccc
     8341 aggcgttctc ggagaccgcc tcccgcgcgg cctcgcgcag caccgacacg gcccacgggt
     8401 caccggtggg actggccgac agcaggtgcc gggccgaccg cttgggtggc gagccgaggc
     8461 ggtgcagcag cgaggccgcc cgccggtgca actcgtcgcg cgcgcgagga tccatccgcg
     8521 cgaggatcgt cgactggacg aggtcgtgcg tgaaccgctg cggggggctg ccctccagca
     8581 ggccggcccc cgcgagtgcc tgtcccgcct cctcggccgc gaccgcgccg tacccggcca
     8641 gcatcgccgc cgtctccagc ccggcgtacg gcgcgatgat ggccaggctc tgcaggaggg
     8701 tgaggatgga cggatacctg ccgccgagcc attcgaggac ggtctccgac agagcgatgg
     8761 cgccgatccg ctgcaccctg ggcagctccg agcggtccgg caggacgtcg gcggcggcca
     8821 gccgtgccgc cgtctccagc aggagcagcg ggttgccctt ggtgaggcgg tgacaggcgc
     8881 tcacgatctc gtcgtccacg gaggcgccca gcgccgactc gacgagcgtg gcggcgcatt
     8941 tccggcacag cgcggagggc ctcagcgacc gcgcgtacgg cagcgccagg atgtcccgga
     9001 ccgtctcgcc ggcgctgcgg tcgtccgcgt cgcaggtcag gatcatcgcg atgggcaggc
     9061 cgtcgagccg ccgggcgatg taggagcacc actgcgccga ctgagggtcg gcatggttga
     9121 ggtcgtcgac cgcgatgatg agcggctgtc ccgcggtcag cgagcgggtg gcccggtaga
     9181 ggtcgtcgag cagcgtggcg ggcacgcccg gcgcgctccc gtcgtacgcc acggccgtca
     9241 tcgcgggcgc gtgcacgttc gcctcgagga cggcggcggg tacgccgagc tcggccgccc
     9301 gtcccgagcc gctcatcatc gggtcgaaca actgacggac gatgccgaac gcgaaggagc
     9361 gctcgtcggc gtgaccccgg gcgctcagga ccactccacc cggcctgcgc gccagcgcgg
     9421 cgtgcagcag ccgggtcttc ccgattcccc gggtgccctg aatcaccagt acggccggcc
     9481 gcccatcgga aagcccggcc agtacgtcgt cgacgacctc tagctccttg tcacggtgca
     9541 gtagtaccgg ccgccctgag gccatcccta cccccggacc acatgcttat ttttccgaca
     9601 cacggatcat gccggacagg gtcggccttc tgtcaatacg tgaaatctag tcgagtaaac
     9661 acacaatcac cgacaagtag tggttgattc ccgtcaggat ttccggtccg atgactgggg
     9721 tgaatcgccc attcgtagcc ggaaccctca cgcgtccggg aattcgggcg gccgaatcgc
     9781 cgcgacggcc cggcgcccga tgccgtcgga gcccgtgggg catacgtatt ccgccgcgcg
     9841 gccggcgcat acgcatcgcc gtacgcacca gtccggattc cgcgttgtgc gggcgatgcg
     9901 tacgtatata tccgtatggc gataaatacg tctttacttc ctcctgaatc caatggaatt
     9961 ctccgctcat cggctaatcg cgcagtgaat ggcggggggc atggaacggc cacggctaaa
    10021 ggcgcacttc accaccgaag tcctcgacga cgcgaaagtc ttccttctgg cggagggcca
    10081 gcactatctc gtacgcggcg cgggctcggg ccgcgtcctt ccctatctcg acggccggca
    10141 cacggtgatg gacatcgtcc aggcactggc cggcgaactg tcaccggccc aggcggtcct
    10201 cgccatccgg cgctatgagg ccgccggtca cctggtcgag ggccggccgg ccctgaccga
    10261 tccggtgctc gctttctggg acgcgcaggg catcgacccc gcggccgtcg tcacggccct
    10321 ggagcagacc tccttccgcg tgttcgcggg cacgggcgtc gaccccggac cggtcgaggc
    10381 gctgctgcgc gagcacgggc tgcgcacgga tccgcacggc gacggcatgg tcgtggcggt
    10441 ggtcgacgac taccttgacc cgggtctgga ggagctcaac gccgagtgcc tggcggccgg
    10501 gcggccctgg gtgctggtca ggccggccgg caccgtggcc tggctcggac cgctgttcca
    10561 gccgggtgac acgggctgct gggcctgcat gtcccagcgg ctcgagggca accggcaggt
    10621 cgagcgttac ctggcgggca agcggggcgg cgggcggccg acccatccgg tgcgcgaggc
    10681 tctgccgggc ggcgtggcgg cggtgggcgg gctgctcgcg gccgagctcg tgcggaccgc
    10741 cgccaccggc gaaccctcga cgctgcaggg caaaatgatc acggtcgacc tgcgcacgct
    10801 caccaccgcc gagcaccagc tgatccggct gccgcagtgc ccggtgtgcg gcgatccctc
    10861 gctgatccgc gagcgcgagc cgaaggtggc gctggcctcg aggaccgccc ggcacgtgac
    10921 cgacggcggc taccgggtcg agcagccctc ggcgacgtac gcccggctcg agcggcacgt
    10981 cagcccttat ctgggcgcgg tcaccgggct gcgcccgtgg accggcgagg acaacggggt
    11041 tacctacagc tacaccgcgg gtcacaactt cgcgatgctc ggcgacaaca tggacctgct
    11101 gcgccgcaac ctgcgcgggc agagcggcgg caagggccgg accgaggttc aggccaaggt
    11161 cagcgcgctg tgcgaggcga tcgagcgcta ctcgggcgtg tggcgcggcg aggagccggt
    11221 gctcaaggcg gcctacgccg acatcgggga gggcctcgcg gtccacccgg acgacctgct
    11281 gctgttctcg gacaagcagt acggcgaccg gtccgcctgg aacagcgacc cctcgcaccg
    11341 gctgcacctg gtgcccgaga ggttccgcac cgacctgccg ctggactggt cgcgggcctg
    11401 gtcgctgacc gccgacgagg agcggctgat ccccgccgga tacgcctggt acggccaccc
    11461 cgacctggaa cgtcacttct actgcgtcgg cgactccaac ggcagcgcct cgggcaacac
    11521 cctggaggag gcgatcctgc aggggttctg cgaggtggtg gagcgggacg cggtcgcgct
    11581 gtggtggtac aaccgggccc gcaggcccgc cttcgacctc gactcgctca acgagccgta
    11641 cgtcgacacg ctgcgcgagt tctacgcgga catgggccgc agcctgtggc tgctcgacct
    11701 gaccaccgac ctcggcgtgc cggccttcgc cggcgtctcc caccggctcg accacccggt
    11761 gcaggacatc atcgtggggt tcggcgccca cctcgatccc cggatcgccg cgctgcggac
    11821 gctgaccgag gtcaaccagt tcctcccctc cgtacgccgc agggacgaga acggcgagac
    11881 gatctatcac gacgacgaca tcgccacgct ccgctggtgg aagggcacga ccatcgagag
    11941 cgatccctgg ctgctgcccg accccgcgca gcgtccccgc acactcgcgg accacgtggt
    12001 gccacaggac accgacctcg cggccgacgt cgagacctgc gtcgcccggg ccgccgcctg
    12061 cgggctggag atgatcgtgc tcgaccagac ccggccggac ctggagctca acgtggcccg
    12121 ggtgctggtt cccgggatgc gccacttctg gcgcaggctc ggcccgggcc gcctgtacga
    12181 cgtcccggtg gccctcggct ggcggacgca gccggccacg gaggaggaac tcaaccccac
    12241 gagcgtcttc ttctgacccg atagggggag cgatgcacac cgttgaggtg cggctgcgcc
    12301 gtgacgccgg cctgtcggaa ccaggggaga cgccgggggc ggtcactttg accacgccgt
    12361 tcggcccggc cgcgctgcgg ggcctgcccg cgggcgcggt cgccgcgctg cgcgtgctcg
    12421 cgggcggcgg tgcgagcgag gaggagctgg ccgggatcgt caccgggcac gacggcgagg
    12481 gcgggctgct gcgctggcac atgctgctgc gcaagctgtc ggccggggcg ctgctggagc
    12541 gggccgtggc gccgtccggc ggtgagccgg tggccgtgct gcgtccctac ggcggcggcc
    12601 ctctgcgccc ggccgcgccg ctcgccgcgg acacccgggt gcgcctgtcg aggttcgccg
    12661 tcgcggggcc ggaggacggc aggctcgtgg tgcgcgcgcc ccgtagtccc ctcggggtcg
    12721 agctcgcccc ggccgccgcc ccgctgctcg gcctgctcgc ggactggacg accccggccg
    12781 cgctcgcctg ccccggcctg ccggccggga ccacggcggc cgtcctcgga ttgttcgccg
    12841 atgccgggct gctggtgcgg ccgacgccgg agggagagga ccccgagcgc ggcgccgcac
    12901 cgctcgccca atggtcgccg gccgacctgt ggctgcacac ccgcacccgg gaaccgcgca
    12961 cgaccgggcg ttacggcggc acctatcccc tgaaaggtgt gtgggatccg ctgccggcga
    13021 cgccgcccgc cttccccggt ccccggatcg ccctggagcc tccggacctg gacgcgatcg
    13081 cgaagaccga ggccggtctc accgaggtgc tggagggccg ccgctcgatc cgcgagcacg
    13141 acgccgccgc cccgatcacc ctggaccacc tgggcgagct gctctaccgg acgatgcgcc
    13201 agcggcgcac gttcaccggt gaggacggcc aggagctggc cgaccggccc tatccgtccg
    13261 gaggcgccgt ccacgagctg gaggtctacc ccctcgtcgt ctcctgcgag ggtctggagc
    13321 ccgggctgtg gcactacgcc gccgacgcgc acgcgctgga acgggtggcc gatcccggcc
    13381 cggcgacccg gatcctgctc gaccgggcca ggtcggcggc catgatgacc gaggaccccc
    13441 aggtcctgct gatcgtgacg gcccgcttcg gccgggtgat gtggaagtac gagaccatcg
    13501 cgtactcgct gatcctcaag cacgttggcg tgctgtacca gaccttctac ctggtggcca
    13561 cggccatggg tttggcggtc tgcgggctcg gcggcgggga cgcggcggag ttcgccgcgg
    13621 cgagcggcct cgacccgcac gcggagggca gcgtgggtga gctcctgctc ggcagcaggc
    13681 cgggtgccgc ggcggggacg ccgccgcgat ggccgacggg ggggccggcg tgaagttccg
    13741 gttgaaggcc ctgcagcgga tgcgggagcc cgacgagctc gactccccga ccctgctcgc
    13801 ctctccgcgc ggctggatcg ccacgttcgt cgtgctgatc gtggtcgtcg ccgcgggggc
    13861 gtggtcgttc gtcggccggt tgccggtcac cgtcaccgcc aaaggactgc tgacccgtcc
    13921 ggcgggcacc gccgagctgc agagccccta caccgggacc gtgcggacca tgatggtgag
    13981 ccccggcctg cgggtggtgc gtggtcaggc ggtggcggag gtcctgcggg ccgacggcac
    14041 cgtgcgcacc gtgagcagcc cgttcgcggg cgaggtcgtc accacgtcgg cgagcgtggg
    14101 cgcgatggtc cgcgagggcg acgggctgct cgcgatggag cggaccgacg atccccacga
    14161 ccgcctggtc gcgatgctgt tcgtgccggg cgaccacgcg ctcggcatcg cccccggccg
    14221 gatggtcgac ctcgcggtcg ccgacgcccc gcccggagtg ttcgggctgc tgcgcggcaa
    14281 ggtgacctcg atcagcccct acccgctgat ggcggagggc gtcgccggcc tcgtcggcgg
    14341 ggacctcgcg gcgcgcggct acgtcaccgc gcagccgccc cgcctggtgg tcgtcgacct
    14401 cctcccggac gcggcgaccc cctccggcta ctcctggacg accgagaccg gtcccccgac
    14461 gaagctgcgg tcgcaggtca cggtgacggg cacggtcacg ctcagcagcc agaccccctt
    14521 caacctgctc ctcggacgct gagaaggaga cggatgagcc aggtcacggc gccccgcgcc
    14581 gacgcccagc cgccccgcgc cccgcgcagg cgcgctcatc cccgaagggg cggccggcgc
    14641 gggagcacac cgaccgtcat ccagatggag gccgtcgagt gcggggcggc cgccctcgcc
    14701 atgatcctcg gccactacgg caaattcgtg ccgttggagg agctgcgggc cgcctgcgcg
    14761 gtgtcccggg acggtgccaa ggcgtccagc gtgatcgccg ccgcacgcaa gtacgggctg
    14821 gaggccaagg gcttccagat ggagctggac gacctgcgtg acgtcgtcaa accggcgatc
    14881 atcttctggg cgttccagca cttcatggtc gtcgagggca tccgtacccg cttcggcagg
    14941 caggcggtgg cggtcaacga ccccgcgagc ggtccccgcc tgctcgactg ggacgagttc
    15001 gactcgggct tcaccggcat cgtgctgacc ttcgagcccg ggcccgggtt ccggcccggc
    15061 ggccgcccca cccgggtggc cgaggcgctg ctgtcgcgcc gcatgcccac cggccgggcg
    15121 ctgccgctgg tgctgctggc gagcctgctg ctggtcgtgc ccgggatcat cgcgccggcg
    15181 ttcagccggg tgttcatcga ccacatcctc accggccgca gtcccggctt catcctgccg
    15241 ctgctgctgg cgatgtcgat gaccgccctg gccatgttcg tgctgacctc ggtccagcgg
    15301 cactacctgc tgcggatgga gatacggatg gggctggtca gctccgcccg tttcttccgt
    15361 catctgctgc gcctgccggt ggagttcttc ctgcaacgca ggcccgccga ggtctccagg
    15421 cgggtgtcgg ccaacgacac ggtcgccgaa atcctgtcca gggatctggc gatcaccgtc
    15481 gtcaacctcg tcctggtgct cttctacgcg gtcgtcctga tccggtacga cctgctgctc
    15541 ggcctcatcg gcgtgggcat ggcgctgctc aacatcgtgg tcctgcggca ggtgtcgagg
    15601 gccaggaccg acgcggtggc cgctttgcgg gccgacctcg gcaacctcac ctcggccacc
    15661 ttcaacacgc tgcagctcgt ggagaccgtc aaggccaccg gcgccgagcc cggcgcgttc
    15721 cagagatggg ccggtttcct ggccaaggcc gtgaccgccc ggcagcggct gggtgtgccc
    15781 agcgcggtca tcacggtcgt gccaccgctg ctcgccgggg tcaacagcgg gctcatcctg
    15841 ctcgtcggcg gcctgcgggt ggtggacggc gcggtcagcg tcggcctgct ggtggccttc
    15901 cagagcctgc tcggcgcact gtcgcggccg gtcacccagc tcaccaacct cggcgggcgc
    15961 ctccagtaca tctcggccga catcacgcgc ctgtacgacg tggaacgtca cccccgctcg
    16021 cccgtcttcg accgtgagga caggcccttg ggcagccgcc tcgacgggtc gatcaccttc
    16081 gacgaggtga cgttcggcta caacccgctg gccaagccgg tgatcagaca ggtgtcgttc
    16141 tcggtggtgc ccggccgccg ggtggcgatc gtggggagct cgggaagcgg caagtcgacg
    16201 atcggcaggc tcgcggcggg gctgtacggg cccacctcgg gccgggtgct gctcgacggg
    16261 cgcgaccgcc aggagatctc gcggaccgag ctggcggcct cgatcgcgta cgtggaccag
    16321 gacatctcgc tgttcgaggg cacggtgcgc gacaacctca cgttgtggag cgacgacgtc
    16381 tccgacgagg tcgtcaccgc cgcgctgcac gacgcggcca tcttcgacgt catctccgcc
    16441 cgccccggcg ggctcaacag cggggtgcgc gagggcgggc gcaacttcag cggcggccag
    16501 cgtcagcgga tggagctggc cagggcgctg gccgcgcagc cgaccctgct cgtcctcgac
    16561 gaggcgacca gcgcgctgga cccggagacc gagcgggtga tcgccgacaa cctgcgccgc
    16621 cggggatgcg cctgcctgat catcgctcac cggctgtcga ccgtacggga cgccgacgag
    16681 atcctcgtgc tgcacgaggg cgaggtggtg gagcgcggca tacacgagga cctggtgcgc
    16741 ctcggcgggc actacgcgcg gctgatcgag aacgcccgga cgggcggcga gggagcggac
    16801 caatgagcgt ctcgaccgtg gcggaatccc cggcgttctc gtcgttcttc accgacgcgg
    16861 ccacgcccgt cgactactcg gccgaccggc tgctcgtgct cgccgacctg cgcgaggtgc
    16921 tgctggtcga gcacggcgcg gtcgacctgt tcgccgtacg cctggagaac ggcaggccgg
    16981 tcggcaggtg gaactacctg tgccgggtgc ggcagggcac gctgatgctc ggctcgcccc
    17041 ggggacccag gcacagcatc gtcgggcggc cggtgctcgg cacccgcgtg tcgcgcctgc
    17101 cgctggcccg gctggagggc ctgtcggccc ggcgcgtcca cggcccgtcc cgatcgggca
    17161 aggcggtccg cgccctgtcc acccgcgagt acggcctggc ggtgggcgag ttcgtgcggg
    17221 gcctggatgc cggggtggtg gcgctcgccg cgtcgatccg cgacacgctg cccccgcgcg
    17281 acttcgtccc gctggtgccg cacgagcccg tcgtcgtccg cgagggcgag gccgtccgtt
    17341 cggtcgacgg cgtccagtgg atcaccgtcg aggacggcgt ggtcgagatg cccgagggcg
    17401 tcgccggtca gctcagcgcg ggcgccgagg tctgcgtcac cgagcgggac tggctggtgg
    17461 cgctcggccc ggcccggctg cgcgcccggt cgaccctcga cctgctcggc gagggcgcgc
    17521 tgtggcaccg gtgggtcgag tacaccaccc gcttcctcta cacgatcgac cggcgggtcg
    17581 aacgccggaa ctccgccgag ctgaaggtgc tgacgagccg ggccgagcgg ggcggggacg
    17641 tgctgcgcac caccgcccgc gggttcgaca cgctggtgcg cgacaccgag gcgcgggtcc
    17701 gcctcgccga cgtcgcgggg gatccgcccg cactggccgc cgcgcgcctg gtggcctcgc
    17761 acgccggctt ctcggtgacc gcacccccgc agggaggggc gcacggcggc cggatcgacc
    17821 cgctccaggc catcgcgctc gcctccggcg tgcgcacccg caggatcagg ctggacgacc
    17881 gctggtggcg gcgggacatc gggccgatgg tgggctacct cacctccgac ggtgcgccgg
    17941 tggcgctgct gcccatcggg tcgcgctacg tcatggccgc gccgggggag gagcgcgtca
    18001 ccccggtcac ggcggcggtg gccggcaccc tgacccggca cgccgacgtg ctgtacgagc
    18061 cgctgccgcc caccgtcgcc ggggtgggcg ggctgctgcg gttcgggctc gccaagaacc
    18121 gcaaggacct gtggaccctg ctcagcctgg gcacactggt ggccgtcatc ggcctgctgg
    18181 tgcccgccat gaccggcctc gtgctcggca cgtacgtggc cagggccgag cgcgagatga
    18241 tcgtgcaggg cgcgctgctg gtgatcgcgg gctcgctcgt ggcggccgcg ctgtcggtgg
    18301 tgcagaactt cgccgcgctg cgcatcgagg gcaggtcgtc gtcacgcctg caggcgggcg
    18361 cgtggatgcg gctgctgtcg ctgccggcga cgttcttcac caactactcc accgccgagc
    18421 tgggcaccac ggtcctcggc gtcagcgcgg tgcaggagac gctgtccggc gtcatgacga
    18481 cggcggccct cggcctgttc gccggcctgg ccaacctcgt gctcgtctac ttctacgacg
    18541 tggggctggc gctgatcgcg acggcgctcg tgctggccgg agtgctcgtg tgcgcggtcg
    18601 cgggctgttt cgaggtgcgc ctgcagcgcc ggctctacac gcacgagcag cggctgtcgt
    18661 cccgggtctt ccagcttctt acggcggtgc cgaagctgcg ggtggcggcg gccgaggacc
    18721 gggccttcgg ggtctgggcg tcgcagttcc tcagggcgcg cagcatcggc gtgtccgccc
    18781 gccgggtgca gaacttcgtc acgaccttca acgccggctt ccccctggtc gcctcggtca
    18841 tcgtcttcgc cgtggtggcc gggccgatgc tcgggcaggt ggccgttccc gcgttcctgg
    18901 cgttcttcgc cgcgttcaac ctgctgctgg cctcggtgct gcagttcacc ggcgcggcga
    18961 tcaccgcgat gagcgtggtg cccatgctgg agcggatgcg gccgatcctg gcggccgagc
    19021 cggaggagca cacgggcaag gccgatccgg gcgagctgtc gggccggatc gagctgtcgc
    19081 gggtgtcgtt ccggtacggc gaggacgggc cgctcgtcct ggacgaggtg gacgtgtcga
    19141 tcgagcccgg tgagttcgtc gccgtcgtcg gcccgaccgg cagcggcaag tcgacgatcc
    19201 tgcggctgct gctgggcttc gagtcgccga gctcgggcac ggtcctgtac gacggccagg
    19261 acctgggcga gctggacatc ggcgcggtgc gtcgccagtg cggggtggtc ctgcagaaca
    19321 gcgcgctgct ggccggcgac atcaagacca acatcatcgg cagcaccgat cacacgaccg
    19381 acgacgcgtg ggacgccgcc ggcatggcgg gaatcgccga cgacatcgcg aacatgccca
    19441 tgggcatgca cacggtgctg tcggagggca ccaacacgtt gtcgggcggg cagcgccagc
    19501 gcatcatgat cgcgcgcgct ctcgtctcgc acccccgcat cgtgctgttc gacgaggcga
    19561 ccagcgcgct ggacaacccc acccagaaga tcgtcacgga gagcacccgc cagctcaacg
    19621 ccacccgggt cgtgatcgcc caccggctct cgacgatcag ggacgccgac aggatcgtgg
    19681 tgctcgaccg cgggcgcgtc gtccagcagg gcagatacca cgagctgctg gaggacgccg
    19741 gcgggttgtt cgcccggctg gcccgccggc agatctgacg accggagacg tgtgcgccgc
    19801 cggcggaccc ggggtccgcc ggcggcgcct gtgtgcccgg tagcggtgct cagtagcggg
    19861 gcttgcggct catcgcgatg ccggcgatga ggaacaccac gccgagcccg ccgtacacga
    19921 aggcgtgggt ggtggcgggc ggcttcacgc tggcgttggc gatggccagc ccgaggccca
    19981 ccaggccgct gatgtagcag aagatcgcta gaaagatctt ccagaagggg ctcatgacgt
    20041 actccgttcg gactcggcgg gaccacccgg tgcggtcccg gcgacgacga ggccgagcaa
    20101 catgacccag gcgtcggggt cggcgcggaa acgccgccac cggtcggccg ccagggcgag
    20161 ctcgggcagg gacagggccc cggaggcgac cagcggcgcc agccgctccg gccccatgtg
    20221 gggggcgaac gcctcggtgg ggcggtcgtc gttggtggtg gcgaacggcc gcagcaccac
    20281 ctcgcggaag cccgcgcggc gcaggatccg ggtgagcttg cggccgatca gccggtcgcc
    20341 tccggcctgg cgctgcgccc cggccatgcg gccgtggacg ccggccagtt ccgggtacat
    20401 cgggtcggcc aggccccaca gcatgctgtc cacctcgatc acgaccagcc gcccgcccgg
    20461 ccgcagcacc cgcagggcct cggccaccac cgccgcgggg tcggccacgt gctgcaggac
    20521 gtaccgcagc aggaccgtgc ccaccacgcc gtccgccagc ggcagccgta cggcgtcgca
    20581 gcccatcagg gggacccggg cgtccgccgc gtgcgccagc agcgcggtgt cgatgtcggc
    20641 ggccacgatg ggcaggtccg gcagcgcggc ccgcagccgc cgcgtgacgg cgcccgagcc
    20701 cgccccgagc tccagcaggg gggcggggac gccgacgtcg agcaggaccc gcagctcctc
    20761 gtcgaaggag agctccgcct gggcctccag ccgtgccagc tcgccggaca ggcctccggc
    20821 ggtcgtcgtg gccgggtcgt aggagccggc gctcaccccg ctcgccccgc tcatctgggc
    20881 ctcgggacca tcagcatgcc gtgccggggg cgcagcgtga cgagggcctc gggctcgacg
    20941 gggaagccgg ggacgagctc cgggcgcacg ccgcgcagca gtacggccag cacgagagtg
    21001 gcctcgacca tcgcgaagtg gcggcccacg cacacccgcg gaccaccgcc gaaggggagg
    21061 tactggtgcc ccgcgtgggt gtgctcggcc gtgaaccggt ccggtgcgta cgtctccggg
    21121 tcgtgccagt accgcggatc ccggtggagt acgtacgggc tgacgcacac gagcgtgccg
    21181 ggcggtatcg ggtagccgcc gacgacgtcg gcctcgacgg agcgccggga gatgagccac
    21241 acgggcgggt acagccgcat ggcctccttg atcgcccgct ggcaggccgc cagccggggc
    21301 aggtcggccg cggtggcggt ccggtccccg cccagcacct cgtccacctc cgcgcgcacc
    21361 gcccgcgcga catcggggtg gcggtcgagg aggtagagcg tccaggtcag cgccttggcc
    21421 gtggtctcgt gcccggccat gacgatcgtc agcacctggt cgcgcaggtc ggtcgcggtc
    21481 atcgcgtgcc ccgaggccag catcgcgccg agcaggtcgt cgccctcctg gccggtggcc
    21541 cgccgggcgg ccacgatcgc ccgcgtgaca ccgtcgagga acgccttcgc ccggcggaac
    21601 ccctccctgc cgcctccctc ggacgcgggg tcgaagtggc cgatgaaacg gttgacctcg
    21661 tccaccgccc gtccgaagcc gtctccgacg cccgcgatgt cggcgccgag catggcccgt
    21721 gcgaggacgg tgagcgtgag agaagtcagg tcgtggtcga cccggaccgc cgcgccctcc
    21781 tcaccggccc gccgccaccg ctcggtcagg ccggccgcgg cgtcggtcat gatctggtcg
    21841 aaccgctcga cctcggtcgg gcggaaggcc ggggcgatca tcttgcgctg ccgggcccac
    21901 tcctcgccgc cgctggtcag caggccgttg ccgagcagag gacgcagcat gtcgtcgtcg
    21961 ggcgtgcggt ccttggtgta gttggcgccg ttgtccttca gcacgtgccg ggccaggtcg
    22021 ggccggtgca gcatgtagac cggcccggtc tccgtctcgt gcctggtcac gtcgccgtag
    22081 gcggccatct cggtgacgaa gcgcagcggg gcctcccgca tcgcgcgcag actctgggcg
    22141 ccctgcggcc ccggtggcag ggatacgtat cgattgtgcg taccggccat gcccaccccc
    22201 agttttcagt aatacgtatt ctccggggaa ttgcgcatgc gattcacggc caatacgtac
    22261 cgggtgatat ttcctgatcg gagcatagtc tccgtcgtgc acggcctcaa tacttatgcc
    22321 ccggcgcgaa aattaagtct gtcccggact tcccggccgt gtaagactcc attttgaaag
    22381 cggcgaaaca caacgccgcg aaaaagccgg gaggcatgtc atgtctttgg acccgaggca
    22441 gcgcgcggaa ttcgtgaacg cgtacacccg cgttctgatc acggcgtggt cgagtgagga
    22501 atactcggcg cggctggact ccgacccccg ctcggccctg gccgagtccg gtctggagct
    22561 gcccgcggga gccgaggtcg tgctcgtccg taacatcccc gagggccacc acgacagcaa
    22621 catcgacgta caggtcgcgc tctgggagcg gggcctcgag acgggccggt tcgagctgca
    22681 catccccgag acgccgcagg tcgacatggc cgagctgagc gagggcgacc tcgactccat
    22741 cgcggccggc gcgagcgcgc aggaagcgat cgacatcaac tgctgctgct gcccctgctg
    22801 ctgctgcacc tgacatcacg acccactcgg aggaccaggc catgtccacg gtcgccgacc
    22861 aggcgaatcc cgtccacgtg cgctccctgc gcaagcggta cggtccggtg aacgcggtcg
    22921 aggaggtgga cctcgacgtg cggagcggcg aggtgttcgc cctcctcggg ccgaacggcg
    22981 ccggcaagac caccacggtg gagatcctgg tgggcgttcg ccggcggacc tccggcgacg
    23041 tgcgcgtcct cggccgcgac ccggccgagg acgcgcccga gtggcgcgcc cggatcggtg
    23101 tcgtccccca gacgacgggg gcgtacaccg atctgaccgt acgcgaggtg gtcgagcact
    23161 tcgcgtcgtt ctatcccgcg ccgctgccgg tggccgaggt gatcgacatg gtcggcctcg
    23221 gcaagcaggc gcgcaagcag gcgcagacgc tctccggcgg ccaggcgcgg cggctcgacg
    23281 tcgcggtcgg cgtcgtcgga gaccccgatc tgatcttcct ggacgagccg acgacggggc
    23341 tcgaccccgt cgcccgccgt gaggcgtggg acctcgtccg ctatttcacc ggccggggca
    23401 agaccaccgt gctgaccacc cactacctgg acgaggtcga ggcgctggcg cagcgcgcgg
    23461 ccgtcatcgt caacgggcgg gtcgtcgagt cgggcccggt gacggagctg ggcggccggc
    23521 gcgcgacgcc cgcggcggtg agcttcgcca ggacggacgg gctcggcgcg agcctgcccg
    23581 cgctgccggg cgacgccgtg gtggaggagg cggagggcct ggtcgtcgtg cgtacgcacc
    23641 atcccaccga ggccatggcc gcgctgctgc cctgggcggc ctcctccggc gtccgcgaac
    23701 tgccggacct gcgcatccac cggccgtcgc tgg
//
