LOCUS       NZ_JABBXA010000004     27279 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H13382 NODE_4, whole genome shotgun sequence.
ACCESSION   NZ_JABBXA010000004
VERSION     NZ_JABBXA010000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H13382
  ORGANISM  Microbispora sp. H13382
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 488556)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 488556)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Antibiotics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014161445.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 07:22:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,906
            Genes (coding)                    :: 7,786
            CDSs (with protein)               :: 7,786
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 21 of 121
            Pseudo Genes (incomplete)         :: 104 of 121
            Pseudo Genes (internal stop)      :: 8 of 121
            Pseudo Genes (multiple problems)  :: 11 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:45:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 291932
            Orig. end                         :: 319211
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBXA010000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27279
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="2"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..27279
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27279
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:17279](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..17279)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            119..2932
                     /locus_tag="HHX41_RS11095"
     CDS             119..2932
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890451.1"
                     /locus_tag="HHX41_RS11095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbohydrate-binding protein"
                     /protein_id="WP_182905873.1"
                     /transl_table=11
                     /translation="MSSRHRPWLRLLTTMSLVASGVAVAAATGPAARASTIPASDYQQI
                     SLASGGAALGEPMSLAVLPDRSVIHTARDGTVRVTSAAGSTKQAGKLNVYTHDEEGLQG
                     VAVDPGFATNRYVWLYYSPALNTPGGDAPTTGTQAQFDQWKGNLNLSRFTLNADNTLNM
                     ASEKVVLQVPNDRGQCCHVGGDIDFDAQGNLYLTTGDDTNPFDSAGYAPLDERTDRNPQ
                     FDAQRSSANTNDLRGKLLRIHPEANGTYTIPSGNLFAPGTAKTRPEIYAMGFRNPFRMS
                     VDKATGIVYLGDYGPDAGGTDANRGPGGQVEFNRITGPGNYGWPYCTGTNTASETYGEW
                     TFPNGPSLGKYNCAGGPTNNSFRNNGLTTLPAAKPSWIKYGGDAGSPPEFGSGSESPMG
                     GPVYRYNASLNSSVKFPQSLDGRYFAGEYGRKWIKAIEVKSDGGYGDIGAFPWTGTQVM
                     DMAFGPDGALYVLDYGTGSNNQALWRIEYIGAANRNPIAKASVSKTSGPAPLAVTFSSA
                     GSSDPEGGALTYSWNFGDGTTSTAANPNKTYTTNGTYTATLTVKDPQGLTGSASVIITV
                     GNTAPTVTLNQPADGQLFSFGDTVPFQVNVSDPEDGTIDCSKVTVTYFLGHDSHRHQIT
                     SKTGCSGSIAVPVDGEHDAAANIYGVFEASYTDKGGLTSTSARTLQPRHRQAEHFSAQS
                     GIQLADHTPAEGAKTVGYIDNGDWISFTPYNLSNATSVTARVSSAGSGGTIEVRAGSAT
                     GTLLGSAAVANTGSWDTFVNVTAPISNAPSGTTTLYFVFKGGAGNLFDLDAFTFNTGTS
                     QTVEGEAYTSQSGVQPAAHAGASGGYTLGYIDNGDWAAYSQVNTQGAKSFSARVSSGGA
                     GGTIQIRSGSQTGTLLGSVNVANTGSWDTFTTVSTTLTGSASGTLFLTFTGGSGSLLDV
                     DTFTITR"
     gene            3023..4585
                     /locus_tag="HHX41_RS11100"
     CDS             3023..4585
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018038.5"
                     /locus_tag="HHX41_RS11100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ThuA domain-containing protein"
                     /protein_id="WP_220503934.1"
                     /transl_table=11
                     /translation="MLPVFRKVFRSAALRCGVAAAAALTATVSLPTAAHAADPAYKVLV
                     FSKTAGFRHDSIPAGIQAIRDLGAANNFTVTATEDSTAFTTSNLAQFKAVVFLSTTGDV
                     LNDAQQTAFASYVDGGGGYVGVHAAADTEYDWPYYGRLVGAWFNSHPAIQQARVKTEDA
                     THPATTGLPATWTRTDEWYNYRTNPRSTTHVLQTLDETSYSGGNMGGDHPITWCHPQAS
                     GRSFYTGLGHTIESYAEANFRTLLLGAIRYAAGMVQANCAPPTGDGTIEAESYTSQFGV
                     QQAAHATASGGKTVGYIDNGDWVGYSSVSTAGATGFTARVSSAGAGGTIQIRSGSQTGT
                     VLGSVSVPVTGSWDTFTTVSTTLTGSASGSLFLVFTGGAGNLFDLDTFSLTKSAATTVE
                     AESYTSQFGVQQAAHATASGGKTVGYIDNGDWVGYSSVNTQGAKGFSARVSSAGAGGTI
                     QVRSGSQTGTVLGSVSVPVTGSWDTFTTVSTTLTASASGSLFLVFTGGAGSLFDVDTIT
                     ITK"
     misc_feature    3062..3064
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4710..4728)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            4878..5099
                     /locus_tag="HHX41_RS11105"
     CDS             4878..5099
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018933.5"
                     /locus_tag="HHX41_RS11105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_310741925.1"
                     /transl_table=11
                     /translation="MTGAAVGLHRARENCVTQAEFACTACGHEAHADANAAVNILRAGL
                     ALRGAHAAQASGCRRASLSSRSPSSVRE"
     gene            complement(5036..6061)
                     /locus_tag="HHX41_RS11110"
     CDS             complement(5036..6061)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039924.4"
                     /locus_tag="HHX41_RS11110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5937 family protein"
                     /protein_id="WP_220503935.1"
                     /transl_table=11
                     /translation="MIHLHFTATDLTRVRFAASPLMETVASLRTLAARRQGRHLHRPWI
                     DRFAERAGRLRERDLDLLRALVRPEGYIPDFLVPPPGRRSSTFADALAQIADADPEIVA
                     QELAHLAAHPVAQQGPGREGRRALLQALVDRPDAGIGPVTEALEAYHRVAIAPDWPRID
                     ALLNDDIAYRLDTLADGGVDRMMSDLHPSVTFADQTLKIVKYYEGHADCAGRGLFLVPC
                     AFAWPDVLLRTAQPEAPSVSYSPRGLGRLWEEHPEQTGSALAGVLGQTRAALLAQLDLP
                     MSTSQAATQMALSAPTLSVHLQALRAAGLLTSRRAGRQVLYSRTELGDRLLSEARRQPD
                     A"
     misc_feature    complement(5567..5569)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6163..6744
                     /locus_tag="HHX41_RS11115"
     CDS             6163..6744
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658251.1"
                     /locus_tag="HHX41_RS11115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_169988071.1"
                     /transl_table=11
                     /translation="MRTLIYTAFVSLDGVVDSPGGGSRSEAHRSGGWTFKDIEFLPEAY
                     ELKGRETEEATALMFGRTSYEVFSPVWPDMEEFAALKELPKYVVSTTLGQDALVDNWGD
                     ITILRSLEDVVKVKETDGGSIFIHGSATLARNLSDAGLIDRYHLLVFPVLLGAGKRMFS
                     DTDKDKQMLKVVESETYANGITKLVYDVVR"
     gene            6755..7837
                     /locus_tag="HHX41_RS11120"
     CDS             6755..7837
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025393.5"
                     /locus_tag="HHX41_RS11120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="questin oxidase family protein"
                     /protein_id="WP_182905875.1"
                     /transl_table=11
                     /translation="MTRESMTEALPAAYERLHAYGPEFGGDEEGNHGLTNHGPMAVEVM
                     VRRGLDIDVEGWLDRYVRRLAELPGTSAAIQPGEWGAALGQARRLPDWTAYFRHELTER
                     PWQEVLAVWWPRLLPGIVAGSTHGVIRVSHAVRTLRGTACAPARQTLDELAHGLAFWAA
                     RYRELAGVVAPEGALTPQQALTAVTRLNDQSGFIAHRLDRLERSPGWTASLRALKPAAS
                     AEEVPARLESLVDSAARAYLRLGHGSPVLLVHAATAPNAVRHVLPVLPAEQWLPSLTAA
                     WAAVAAVIATYAPARPAPHAEIVRRYPELTREDTLQRAAEHGDEHVLKFADTAVESYDR
                     TGDPELLAATLHVGELIDRP"
     gene            complement(8317..9099)
                     /locus_tag="HHX41_RS11125"
     CDS             complement(8317..9099)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013757.5"
                     /locus_tag="HHX41_RS11125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_182905876.1"
                     /transl_table=11
                     /translation="METLESGSPLESVDRALRLVEMLRHGELLTVKAAAERLAVAPSTA
                     HRLLGALVYRGFAVQDRERRYRAGPAISQQHDTALSTSELRATARAGLDHLHAAVGETV
                     QLMVLQRWSIKFIDGIECDAPLRVGVRVGDLMPAYCSAGGKALLAELSNTDLEVLHRGG
                     LPPWPTARIATLAALKTQLMTVRRRGYGMNNEETEQGVSGVGVAIRDPAGKAVAAFTVA
                     VPSVRFDRSGVSAYVASLREAVELTQAQISDLPRRAPQ"
     gene            complement(9108..10004)
                     /locus_tag="HHX41_RS11130"
     CDS             complement(9108..10004)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008354742.1"
                     /locus_tag="HHX41_RS11130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_182905877.1"
                     /transl_table=11
                     /translation="MTTRYEPAIDVAGVVAIDVHTHIEADRDHRHFALDDELLAASAKY
                     FKSGDNRTPTIDELASYYRERNMAAVVFTVDASTGMNHPALSSEEIAEQAAEHADVLIP
                     FGSVDPRRGSAAVAQARRLVEEYGVRGFKFHPSMQAFEPNSTEFYPLYAALEELGVVAL
                     FHTGQTGIGSGLPGGRGIKLRYADPMLLDDVAADFPGLDIVMAHPAVPWVDAQISIATH
                     KPNVYIDLSGWSPKYFPPQLVRQANSLLKHKVLFGSDYPLLTPDRWLSDFGKLEINDEV
                     RSLIMKDNAIRLLRLTA"
     gene            complement(10001..12025)
                     /locus_tag="HHX41_RS11135"
     CDS             complement(10001..12025)
                     /EC_number="6.2.1.16"
                     /GO_function="GO:0030729 - acetoacetate-CoA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (114-539). E-value: 1.8e-56.
                     Score: 183.4. Matches aSDomain:
                     nrpspksdomains_HHX41_RS11135_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619739.1"
                     /locus_tag="HHX41_RS11135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetoacetate--CoA ligase"
                     /protein_id="WP_182905878.1"
                     /sec_met_domain="AMP-binding (E-value: 3.9e-64, bitscore:
                     211.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADPTVDLATRSAAAGLEPLTSPPYDSSRESGVQRYLRWLETERG
                     LRFSGWDELWRWSVTDLEGFWASIWDYFGVRAHTPYEKVLGRREMPGAEWFPGATLNYA
                     EHAFGLPEDADTVAIVAHSQNRPPMELTFGDLRAQVARAQAGLRRLGVGRGDRVVAYLP
                     NIPETMVAFLATAGLGAVWASCSPEFGPAGIVDRFEQIEPTVLLTVSEYTYGAKHIDRR
                     AAVEEIRAGLPTLKHVVHVPNGTQDLPGTLSWAELLGDPGDAPGEPAFEPVPFDHPLCV
                     LFTSGTTGRPKPIVHGHGGVLLEHLKNHALQWDLQPGDRLLWFSTTAWMVWNMLVSALL
                     TRSSVVLIDGDPTYPDLNFQWRLAERTRTTLMGISPPYLMACRKAGLNPGRDFDLSSIR
                     QIGAVGSPLAAEGYRWIHEQFGDDVLLNVGSGGTDVCTGIVQGSPEQPVWLGEMSGPSL
                     GVDAKAYDEKGDVVVGELGELVITSPMPSMPVGFWGDRDGSRYRDAYFGTYPGVWRHGD
                     WIRFSELGSSVITGRSDATLNRGGVRLGTAEFYRAVEEIDGVADSLVVHLEDPEGGTGE
                     LLLFVVPSAGGPLDETLRDTIVRTIRTGLSPRHVPDRILRLAKVPYTRTGKKLELPVKR
                     ILRGEAPQAVVNMDAVADPDTLTAFADLARHRIHPQGES"
     aSDomain        complement(10409..11683)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HHX41_RS11135_AMP-binding.1"
                     /evalue="1.80E-56"
                     /label="HHX41_RS11135_AMP-binding.1"
                     /locus_tag="HHX41_RS11135"
                     /protein_end="539"
                     /protein_start="114"
                     /score="183.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DTVAIVAHSQNRPPMELTFGDLRAQVARAQAGLRRLGVGRGDRVV
                     AYLPNIPETMVAFLATAGLGAVWASCSPEFGPAGIVDRFEQIEPTVLLTVSEYTYGAKH
                     IDRRAAVEEIRAGLPTLKHVVHVPNGTQDLPGTLSWAELLGDPGDAPGEPAFEPVPFDH
                     PLCVLFTSGTTGRPKPIVHGHGGVLLEHLKNHALQWDLQPGDRLLWFSTTAWMVWNMLV
                     SALLTRSSVVLIDGDPTYPDLNFQWRLAERTRTTLMGISPPYLMACRKAGLNPGRDFDL
                     SSIRQIGAVGSPLAAEGYRWIHEQFGDDVLLNVGSGGTDVCTGIVQGSPEQPVWLGEMS
                     GPSLGVDAKAYDEKGDVVVGELGELVITSPMPSMPVGFWGDRDGSRYRDAYFGTYPGVW
                     RHGDWIRFSELGSSVITGRSDATLNR"
     CDS_motif       complement(11132..11188)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HHX41_RS11135_0001"
                     /evalue="2.20E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="HHX41_RS11135"
                     /protein_end="298"
                     /protein_start="279"
                     /score="20.2"
                     /tool="antismash"
                     /translation="CVLFTSGTTGRPKPIVHGH"
     gene            complement(12018..13121)
                     /locus_tag="HHX41_RS11140"
     CDS             complement(12018..13121)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013491.5"
                     /locus_tag="HHX41_RS11140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PEP/pyruvate-binding domain-containing protein"
                     /protein_id="WP_182905879.1"
                     /sec_met_domain="PPDK_N (E-value: 7e-95, bitscore: 312.7,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVYTVPFDSEACRDVREVGGKALGLAEMTAAGLPVAPGFTVTAA
                     AYRDFLDENGLRDDVRRILGQVDPDDRSTYDAAERALTERLSRAPLPARVADEVRRAYA
                     ELNARIGGGDVPVAVRSSATAEDSGGDSFAGEFETWVDVVGAEDVLAHVHRCYLSVFTG
                     RVLSYAVERGIDLRTVEMAVVVQKTVRARSAGVMFTLDPITGDRSRIVLESSWGLGLSV
                     VGGEVTPDRYVVNKVGLSLDQRVLGDKRVEYRRGDRPVPVPEDRRERLCLEDHEVLALA
                     ALGRKLEQLQGRPQDIEFAVDEDLPQDANLVLLQCRPETVWSSVKRAPAFDAGTGLMSW
                     IVGSIGAGARTPAGAGDGHGHGGHRHG"
     gene            complement(13118..14962)
                     /locus_tag="HHX41_RS11145"
     CDS             complement(13118..14962)
                     /GO_function="GO:0016772 - transferase activity,
                     transferring phosphorus-containing groups [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF006150.0"
                     /locus_tag="HHX41_RS11145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PEP-utilizing enzyme"
                     /protein_id="WP_182905880.1"
                     /transl_table=11
                     /translation="MTANDHSRFPFFNEAQAPDGAAGWESMYPYFLVPSEETREEENSR
                     FWFADTMHWSRGVHPFDSIGAEAVYLGAGQNSTRIFVLPTSLGLDVRVVNGYVYISPIA
                     VTDPEEIGRRASFFQERAGYYYANWDELYGRWKEKMLAAIESMRTLKFTPLPELDPVEV
                     VTEARGRSVSWDVIENYHRLIDEFFLVWQYHFEFLNLGYGGYITFFQFCRQAFPQISEQ
                     DVARMVAGVDVLAFRPDDELRRLAVLAGELDLADRFAGFTATSAADALLDALAGTENGQ
                     VWLKAFEKAKDPWFNYFAEYGFTHDQDTWAGNLSIPLTGIARYVAKLQAGEDISRPVAR
                     LREERDRLVAEYRALLTEEEARQFDELLNLARTVFPYIEEHNIYVEHWAHAVFWEKAWE
                     LGGLLVSAGFTRERDDVFYLNRFELDTVLFDVVESWAIGVPARGSKRWQAEIDRRRGIM
                     AALQSQVAPPAYGIPPEQVTDPFAVMNYGVTTERVQEWLGAASGGDARLTGIPGGPGTV
                     EGVVRVLRTENDLGLLQPGEILVAPITAPSWAAAFSVAVGVVTDIGGMMSHAAIVCREY
                     GLPAVVGTGFATARLKTGQRVRVDGETGVVTILTEAGE"
     gene            complement(14959..15810)
                     /locus_tag="HHX41_RS11150"
     CDS             complement(14959..15810)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024740.5"
                     /locus_tag="HHX41_RS11150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD-IIA family hydrolase"
                     /protein_id="WP_169983233.1"
                     /transl_table=11
                     /translation="MTGPLHAIDAWVLDVDGCLMRTAHAGGAGGTPMPDAVRFVSALKA
                     AGHEVVICTNASEQPPGTYAEHLRAHGFDIADDHFVTAGSAAADFIAREHPGARVLVVG
                     EEGLRDPLRRLGVALADPGDLADVVVVGAARSYGTAELNAAGLAVDAGAPLYTTVDVRW
                     FHGGLGKSICASAAIANAIGWVAGAEPRVLGKPSPALAATLAHRLGRPPGRVAVVGDAL
                     VEVRLARHMGAHALLVLSGATTPEQLDGVSQEERPDAVYADVAELYRLLTPHLTMSEGV
                     TA"
     gene            complement(15807..17279)
                     /locus_tag="HHX41_RS11155"
     CDS             complement(15807..17279)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012885.5"
                     /locus_tag="HHX41_RS11155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyruvate/oxaloacetate carboxyltransferase"
                     /protein_id="WP_169983232.1"
                     /sec_met_domain="HMGL-like (E-value: 2e-24, bitscore: 81.2,
                     seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDINLIDVSLRDGNQSLWGAVGVTTRMVEGVAPLLDQVGYRAVE
                     IASSTVLAVAVRFHKEDPWARLRAARDRMPNTRLGFLTTGKRFITFYRTPDALFELAFR
                     LLVRNGVTRLWIIDPMHDMAGAKRMAAMARRAGFEEIVGGVCYTTSPVHTDVYYAERIA
                     ELDGCPDIDNVYLKDPAGLLTPERLSTLVPMLQSKLSRLRLNELHSHSTTGLSPLTALT
                     AADHGIDTIHCALPPLANGNSHPAAQRLVRNLRARGHRLDVDLDAMDRASAYLTRQAKI
                     KRLPAGVPAEYDQDYYRHTIPGGVQSTLARQLGELGRPELVPAVIEESVRVREDLGWPI
                     VMTPFAQYIVTQATLNVITGERYRQISDEVVDLLRGDFGPLPGPVNQDLLDRALSTKRG
                     SRPADDGSSDITLAELRKRFGETTSDEDLLLRAVMPAEQVDAMVAARGSSPASTLRNLL
                     RSVEDRPRLTTVSVQLGDTRLDLTRNAPEEAR"
     gene            complement(17280..18662)
                     /locus_tag="HHX41_RS11160"
     CDS             complement(17280..18662)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541208.1"
                     /locus_tag="HHX41_RS11160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetyl/propionyl/methylcrotonyl-CoA carboxylase
                     subunit alpha"
                     /protein_id="WP_182905881.1"
                     /sec_met_domain="ATP-grasp (E-value: 6.4e-14, bitscore:
                     46.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.9e-14,
                     bitscore: 48.2, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRQADRTRQRVFVANRGEIALRIIEACDRLGFETVLGVSSADRD
                     TLAARRAGQVVVLGGPHATGSYLSIPSVLHTAVSTGCTAVHPGYGFLSERPDFARECAA
                     NGLTFVGPSPEALEALGDKLSARELAESLGVPVSAGGYASSVAEAAELAARIGYPVLIK
                     AAHGGGGRGMKLVESDAGLAEAWALASAEAEAAFGDGTVFLERYVTDAKHVEVQILGDR
                     HGNRIHLGERECSVQYRYQKMVEEAPCAALPQATRERLHDSALRIARALDYVGLGTVEF
                     LYDVRRDELNFLEVNPRLQVEHPVTEAVTGVDLVREQLLAALGEPLSVRQEDVRLTGHA
                     IEARITAQDPYDLLRPSPGTVTRWRPPVGGGLRLDSHIYEGYAFPPFYDALMGKLVAWG
                     TDRAAAAARLNAALAAFEIGGVTTSRDLLRSITRHGDFLAGTVTTHWLNDRYNDLLGDR
                     NE"
     gene            complement(18659..19180)
                     /gene="accB"
                     /locus_tag="HHX41_RS11165"
     CDS             complement(18659..19180)
                     /EC_number="6.4.1.2"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="accB"
                     /inference="COORDINATES: protein motif:HMM:TIGR00531.1"
                     /locus_tag="HHX41_RS11165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="WP_169983230.1"
                     /transl_table=11
                     /translation="MDFDLEELASIIELLDKADFRHFRFEKGDLRITVSRDGNVPLDLA
                     APTVPPPAAVPGAPVQAAPASAAPAPLKNPAKTPLKAPAQAAAEPDEGEIVITAPLLGT
                     FYRSPKPGEPPYVEIGDKVEPDSVLCIVEVMKLMNSVPAGVSGEVTKVFAGDGELVEYG
                     SPLFAVRPAA"
     misc_feature    19204..19224
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.77"
                     /tool="antismash"
     misc_feature    19213..19230
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.82"
                     /tool="antismash"
     misc_feature    complement(19255..19269)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.14"
                     /tool="antismash"
     gene            19362..>19849
                     /locus_tag="HHX41_RS40445"
                     /pseudo=""
     CDS             19362..>19849
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611183.1"
                     /locus_tag="HHX41_RS40445"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MARLKPWEVSDELWAVIEPLLPKHQRRSRYPGRKRLDDRLVLQGI
                     LFVLHTGIGWEHLPQELGYGSGMTCWRRLAEWQKAGVWQRLHEVLLDRLRAADALDFSR
                     AVVDSSHVRALKGGRRPAQARSIEAARAASTTWSPTPPASRWHSPSPVATATTSPSSS"
     misc_feature    19398..19400
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19704..19706
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20374..20940
                     /locus_tag="HHX41_RS11175"
     CDS             20374..20940
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025919.5"
                     /locus_tag="HHX41_RS11175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_182905882.1"
                     /transl_table=11
                     /translation="MSAQYAWPELFPARHQVTDGSDHPAVSPLGDLFSPATEAEVRELE
                     ERLGVELPPSYRQFLLSANGWGSDDDCCLLRVEEVGWLRDVDPSIAESWSAPKPENSWS
                     VPDELYFVYGLEQDSIHFRGEYVPDTLLLGYWDDGAALLNPHVSTVEGEWEAWYLAPWL
                     PGARRYRSFWDLAMDQLRMGVNRIR"
     gene            complement(21261..21791)
                     /locus_tag="HHX41_RS11180"
     CDS             complement(21261..21791)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013340.5"
                     /locus_tag="HHX41_RS11180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YbhB/YbcL family Raf kinase inhibitor-like
                     protein"
                     /protein_id="WP_182905883.1"
                     /transl_table=11
                     /translation="MKLGKRVVAGAVILLLTGCAPGNAGDASPTDGLKVSSPAFAESAE
                     IPEKYVCTQQGGENVSPPLTWTGVPESARELAIVVDDPDAPGGTYIHWIVTGIPVSATS
                     VSEGQTQGKVLPGSDGQAAYAGPCPPSGVHHYHFIVYALRGPVAPSGDAKSTHQQIKDA
                     AVASGETVGVWGS"
     gene            22122..22388
                     /locus_tag="HHX41_RS11185"
     CDS             22122..22388
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF041742.1"
                     /locus_tag="HHX41_RS11185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_182905884.1"
                     /transl_table=11
                     /translation="MRKMLTSLGLAFLLTLAPAAAATAETPVAPATYSQPNPSPQPGQG
                     RDGGGNGGLWGLLGLLGLLGLAGVRKQKHRVGTAEHMSNRPYS"
     gene            22529..24790
                     /locus_tag="HHX41_RS11190"
     CDS             22529..24790
                     /EC_number="1.11.1.6"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542044.1"
                     /locus_tag="HHX41_RS11190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="catalase"
                     /protein_id="WP_182905885.1"
                     /transl_table=11
                     /translation="MDASKPAKAVKEVVENAAEKVTDFLTPDVPGSPGSAPATVEEPTT
                     PRDPLPPKKEQGAPATVTPTGAETGAPATAKGQQGAHLTTAQGARLRDTDHSLKAGERG
                     PTLLQDHHLREKITHFDHERIPERVVHARGAGAHGVFEAYGTAEAVTRAGFLKKGKKTD
                     VFVRFSTVLGSRGSADTVRDTRGFATKFYTDEGTFDLVANNMPVFFIQDGIKFPDVIHA
                     GKPHPDREIPQAQSAHDTFWDFVSLHTEAQHHTMWNMSDRGIPRSFRMMEGFGVHTFRL
                     VNEAGETVLVKFHWKPKLGVHSLTWEEAQMLGGMDPDFHRRDLYDAIEAGAYPEWELGI
                     QVLPDTPDQTFEGIDLLDPTKIVPEELAPVQPIGRMTLDRTPTNFFGEVEQVAFHVGHL
                     PPGIDVTNDPLLQTRLFSYLDTQITRLGGPNFAQIPINRPHCPVNDMLRDGFHQHAVHA
                     GVAPYRPNSLDGGNPFVAGDGEKAYTDVPVEVAQARKVRANPVSFDDHFSQTRLFWLSM
                     TPVEKEHIIRAYTFELGKCYEQAIKERQLQCLANIDPVLCREVATGLGLPAPEPALPLA
                     DPAPSPALSQVGKEWPGDGRMVGIVVDDGADLDGVRDLRKAVFAAGMVPLLIAPHGGTL
                     GDMPVQRTFATARSIEFDALLLAAAPVPAPDALPARDAKAGAGDATVVDPRVMLMIDEC
                     WRHAKAIGAWGGGAKLLAQAGITGTPGVVSGDSATEVFTAVQRSMAAHRVWERFPASVA
                     "
     gene            complement(25043..26224)
                     /locus_tag="HHX41_RS11195"
     CDS             complement(25043..26224)
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541682.1"
                     /locus_tag="HHX41_RS11195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_259400893.1"
                     /sec_met_domain="p450 (E-value: 1.4e-21, bitscore: 71.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPPLHMRRDGFHPVPELSALRNDEGVARIRTVFGTDAWLVTRFE
                     DVRTVLSHPELYSNALVPPLRPPGAPPPSAEEAAAMRAGNLLGSDPPEHTRLRRMLTAQ
                     FTVRRMRRLEPRVQQIVDDHLDAMERGGPPADLVTDFALPVPSLVICELLGVPYADRAG
                     FQGTSKRILDVSLSPDERAAAAAEARAYIAGLIERMRTDPGDDLLGMLVREHGDELSDA
                     ELTGIGTLLLLAGHETTANMLSLGTLALLRHPGQLTLLRDEPDRVGAAVEELLRWLSIV
                     HSGTVKITTSEVRLGDRTLGPGETVICSLPAANRDPGLVPNPDDLDIRRDAIGHVAFGH
                     GVHHCLGAPLARMEMHIAFPALLRRFPGLRLAGEPLFRSLTVVHGLTTMPITW"
ORIGIN
        1 gcctctggcc ggtccctgcc gcagcacccc cggcagtacc cgcaacaccg caacaccggc
       61 aacagcgcgg cggcgcgcgc cttgcctgac tgcacccccc aagtcaggaa ggaccccgat
      121 gtcatcacgt catcggccgt ggctcaggct gctcaccacg atgtcgctgg tcgccagcgg
      181 agtggcggtc gctgcggcga ccggcccggc ggcccgggcc tcgaccattc ccgcctccga
      241 ctaccagcag atctctctcg ccagtggcgg cgcggcgctc ggcgagccca tgtccctcgc
      301 tgtgctgccc gaccgctcgg tcatccacac cgcccgtgac ggcacggtcc gggtcacgag
      361 cgcggccggc agtacgaagc aggccggcaa gctcaacgtc tacacccacg acgaagaggg
      421 cctccagggc gtcgccgtcg acccgggctt tgcgaccaac cgctatgtct ggctgtacta
      481 ctcgcccgcg ctgaacaccc ctggaggcga cgcgccgacc accggcaccc aggcgcagtt
      541 cgaccagtgg aagggcaacc tgaacctatc ccggttcacc ctgaacgccg acaacacgct
      601 caacatggcg agcgagaagg tcgttctcca ggtccccaac gaccgtgggc agtgctgcca
      661 cgtcggcggg gacatcgact tcgacgcaca gggcaacctg tacctcacca ccggagatga
      721 caccaacccg ttcgactccg ccgggtacgc gccgctggac gagcggaccg accgcaaccc
      781 gcagttcgac gcgcagcggt cctccgccaa caccaacgac ctgcggggaa agcttctgcg
      841 gattcacccg gaggccaacg gcacctacac catcccctcg ggcaacctgt tcgcccccgg
      901 cacggcgaaa acccgccccg agatctacgc catgggcttc cgcaacccgt tccgcatgtc
      961 ggtcgacaag gccaccggca tcgtctatct gggcgactac ggcccggacg ccggaggcac
     1021 ggacgccaat cgcggtcccg gcggccaggt cgaattcaac cggatcaccg gtccgggcaa
     1081 ctacggctgg ccgtactgca ccggcaccaa caccgcctcc gagacctacg gcgagtggac
     1141 cttccccaac ggtccctccc tcggcaagta caactgcgcg ggcggcccga ccaacaactc
     1201 cttccgcaac aatggtctga ccacgctgcc cgcagccaag ccgagctgga tcaagtacgg
     1261 cggcgacgcc ggctccccgc cggagttcgg cagcggctcg gagtcgccga tgggcggccc
     1321 ggtctaccgg tacaacgcct cgctcaactc cagcgtcaag ttcccgcagt cgctcgacgg
     1381 ccgctacttc gccggtgagt acggccgcaa gtggatcaag gcgatcgagg tgaagtccga
     1441 cggcggctac ggcgacatcg gtgcgttccc ctggacgggt acgcaggtca tggacatggc
     1501 cttcggcccc gacggcgccc tatacgtgct cgactacggc acagggagca acaaccaggc
     1561 cctctggaga atcgagtaca tcggcgcggc caaccgcaac ccgatcgcca aggcgtcggt
     1621 cagcaagacg tccggaccgg ccccgctggc ggtgacgttc tcctcggcgg gcagctccga
     1681 ccccgagggc ggggcgctga cctactcgtg gaacttcggc gacggcacca cctccacggc
     1741 ggccaacccg aacaagacct acaccaccaa cggcacctac acggcgacgc tgaccgtcaa
     1801 ggatccccag gggctgaccg ggtccgcgag cgtcatcatc accgtgggaa acaccgcgcc
     1861 gacggtgacg ctgaaccagc cggcggacgg ccagttgttc tccttcggtg acaccgtgcc
     1921 cttccaggtc aacgtcagcg acccggagga cggcacgatc gactgctcga aggtgacggt
     1981 cacctacttc ctggggcacg acagccaccg ccaccagatc acctccaaga ccggctgctc
     2041 gggctccatc gcggtgccgg tcgacggcga gcacgacgcg gcggccaaca tctacggcgt
     2101 gttcgaggcg tcctacaccg acaagggcgg cctgacctcc accagcgccc gcacactcca
     2161 gccgcggcac cggcaggccg agcacttctc ggcgcagtcg ggcatccagc tggccgacca
     2221 caccccggcc gagggcgcca agacggtcgg ctacatcgac aacggcgact ggatctcctt
     2281 cacgccgtac aacctgagca acgccaccag tgtgacggcc agggtctcct cggcgggctc
     2341 cggcggcacg atcgaggtgc gagccgggtc ggcaaccggc acgctgctgg gatcggcggc
     2401 cgtcgccaac accggcagct gggacacctt cgtcaacgtc accgcgccca tcagcaacgc
     2461 gccgagcggc acaaccacgc tctacttcgt gttcaagggc ggtgcgggca acctgttcga
     2521 cctcgacgcg ttcaccttca acaccggcac aagccagacg gtcgagggtg aggcgtacac
     2581 ctcgcagtcc ggcgtgcagc cggccgccca cgcgggggcc agcggcgggt acacgctcgg
     2641 ctacatcgac aacggtgact gggccgcgta ctcgcaggtg aacacccagg gcgcgaaatc
     2701 cttctcggct cgggtgtcct cgggcggagc cggcgggacc atccagatcc gctccggctc
     2761 gcagaccggg accctgctgg gttcggtcaa cgtggccaac accgggagct gggacacctt
     2821 cacgacggtt tcgacgacgc tgaccggctc ggcgtccgga acgctgttcc tcaccttcac
     2881 cggcggctcg ggctccctgc tcgacgtcga caccttcacc atcacccgtt agcggcaggc
     2941 cgcggtgcgg aggccggcag gcaaccgcac cgcggccggg cacgcccaga cgaacggcgt
     3001 gccgtacacg gaaggaccag ccatgctccc agtcttccgg aaggtgttcc ggagcgccgc
     3061 gttacgatgc ggcgtggcgg ccgccgccgc gctcaccgcg accgtgtcac tccccacggc
     3121 cgcgcacgcg gccgacccgg cctacaaggt gctcgtcttc tccaagacgg ccggtttccg
     3181 gcacgactcc attcccgcgg gtatccaggc gatccgcgac ctgggcgccg cgaacaactt
     3241 caccgtcacc gccaccgagg actcgacggc cttcaccaca tccaacctcg cccagttcaa
     3301 ggcggtggtc ttcctcagca cgacagggga cgtgctcaac gacgcccagc agacggcctt
     3361 cgcctcctac gtcgacgggg gcggcggcta cgtcggcgtg cacgcggcgg ccgacaccga
     3421 gtacgactgg ccgtactacg ggcggctggt gggcgcctgg ttcaacagcc acccggcgat
     3481 ccagcaggcg agggtcaaga ccgaggacgc cacgcatccc gcgaccaccg gcctgccggc
     3541 gacgtggacg cggaccgacg agtggtacaa ctaccgcacc aacccccggt ccaccacgca
     3601 cgtgctgcag accctggacg agaccagcta cagcggcggg aacatgggcg gcgaccaccc
     3661 gatcacctgg tgccaccccc aggcctccgg acggtcgttc tacacgggcc tcggccacac
     3721 gatcgagtcc tacgcagagg cgaacttccg caccctgctg ctcggagcca tccggtacgc
     3781 cgccggaatg gtgcaggcca actgcgctcc tcccaccggt gacggcacga tcgaggccga
     3841 gtcctacacc tcgcagttcg gcgtccagca ggcggcccac gccacggcga gcgggggcaa
     3901 gaccgtcggc tacatcgaca acggtgactg ggtgggctac tcctcagtga gcacagcggg
     3961 cgcgaccggg ttcaccgccc gggtctcctc ggcgggggcc ggtggcacca tccagattcg
     4021 gtccggctcg cagaccggaa ccgtgctcgg atcggtttcc gtcccggtga ccggcagttg
     4081 ggacaccttc acgaccgtgt ccaccacgct gaccgggtcg gcctccgggt cgctcttcct
     4141 ggtcttcacc gggggagcag gcaacctgtt cgacctcgac acgttctcgc tgaccaagtc
     4201 cgccgcgacc acggtggagg cggagtcgta cacgtcgcag ttcggcgtcc agcaggcggc
     4261 ccacgccacg gcgagcgggg gcaagaccgt cggctacatc gacaacggtg actgggtggg
     4321 ctactcctcg gtcaacaccc agggggcgaa gggcttctcc gcccgggtct cctcggcggg
     4381 ggccggtggc accatccagg tccggtccgg ctcgcagacc ggaaccgtgc tcggatcggt
     4441 ttccgtcccg gtgaccggca gttgggacac cttcacgacc gtgtccacca cgctgaccgc
     4501 gtcggcctcc ggatcgctct tcctggtctt caccggggga gcaggctcac tgttcgacgt
     4561 cgacaccata accatcacca agtaacccaa accgcggtgg tgcccgcccg gggcatcggg
     4621 cgggcacacg cgatctcctg gtgacgggtc gggcgcagca ggaacttgta ggacctacgc
     4681 acggccgctc cccttggggg cgcgctcgta ctgcgtctcg atcgccactt ggccgcgtcc
     4741 gccggccgtc tcgcggcggc ccagcaggtg tcgcccgtaa caagcgcggg tccaagcggc
     4801 gacgcaaagc cgtctccgct ccctgaaggg agcggcttct cgctaagccg cttccgccac
     4861 gcctcggcga cccacctgtg acgggtgcgg cggtcgggct gcaccgcgca cgggagaact
     4921 gcgtcaccca ggccgagttc gcctgtacgg cgtgcggtca cgaggcgcac gccgacgcga
     4981 acgcggccgt caacatcctc agggcagggc ttgcccttcg cggcgcacat gcagctcagg
     5041 cgtcgggctg tcggcgtgcc tcgctgagca gtcggtcgcc gagttcggtc cgcgagtaga
     5101 gcacctgccg gcccgcacgg cgcgaggtga gcagcccggc ggcgcgcagc gcctggaggt
     5161 gcacgctgag cgtcggcgcg gagagcgcca tctgagtggc ggcctggctg gtcgacatcg
     5221 gcaggtcgag ctgggccagc agggcggccc gggtctgccc gagcacgccg gcaagcgccg
     5281 agccggtctg ctcggggtgc tcctcccaga gccggccgag gccgcgcggg gagtaggaga
     5341 cgctgggtgc ctccggctgc gcggtccgca gcaggacgtc cggccaggcg aaggcgcacg
     5401 gcacgaggaa caggccgcgc ccggcgcagt cggcgtggcc ctcgtagtac ttgacgatct
     5461 ttagcgtctg gtcggcgaag gttaccgacg gatgcaggtc gctcatcatc cggtcgacgc
     5521 cgccgtcggc cagggtgtcg agccggtagg cgatgtcgtc gttgagtaac gcatcgatcc
     5581 gcggccagtc tggggcgatc gcgacccggt ggtacgcctc gagcgcctcc gtgacggggc
     5641 cgatgcccgc atccggccgg tccaccagcg cctggagcag ggctcgccgt ccttcgcggc
     5701 cgggcccctg ctgggcgacc ggatgggccg ccaggtgcgc caactcctgc gccacgatct
     5761 ccggatcggc gtcggcgatc tgcgccagcg cgtccgcgaa ggtcgaggac cggcgaccgg
     5821 gcggcggcac caggaagtcg gggatgtagc cctccggacg caccagcgcc cgaagtaggt
     5881 cgaggtcgcg ctcgcgcagc cggcccgctc gctcggcgaa cctgtcgatc cagggacggt
     5941 gcaggtgccg cccttgcctg cgggcggcca gcgtacgcag gctggcgacg gtctccatga
     6001 ggggcgaggc ggcgaagcgc acgcgggtca agtccgtcgc cgtgaagtgc aggtggatca
     6061 cgcggcgccc cttccgatta gatccgagcc taatcgtggc cgtgcgcgtg aggtcaccgc
     6121 agactgagga catccacccc gaccacggat aggacatcga agatgcgcac gctgatctac
     6181 accgccttcg tctcgctgga cggtgtcgtc gactctcccg gcggcggcag ccgctccgag
     6241 gcccaccgca gcggcggctg gaccttcaag gacatcgagt tcctgcccga ggcgtacgag
     6301 ctcaagggtc gggagaccga ggaggccacc gcgctgatgt tcggccggac cagctacgag
     6361 gtgttctcgc cggtgtggcc ggacatggag gagttcgccg ctctcaagga actgccgaag
     6421 tacgtcgtct cgaccaccct cggccaggac gccctcgtcg acaactgggg tgacatcacg
     6481 atcctgcgct ccctcgagga cgtcgtgaag gtcaaggaga ccgacggcgg ctccatcttc
     6541 atccacggca gcgccaccct cgcccgcaac ctctccgacg ccggtctgat cgaccgctac
     6601 cacctgctgg tctttcccgt gctgctcgga gcgggcaagc ggatgttcag cgacaccgac
     6661 aaggacaagc agatgctgaa ggtggtcgag tccgagacgt acgccaacgg catcaccaag
     6721 ctcgtctacg acgtcgtccg ctgaggtggc cgtcatgacc cgcgaatcga tgacggaggc
     6781 cctgcccgca gcgtacgaac gactgcacgc gtacgggccg gagttcggcg gtgacgagga
     6841 gggcaaccac gggctgacca accacggtcc gatggccgtg gaggtcatgg tccggcgggg
     6901 actcgacatc gacgtcgagg gctggctcga ccgctacgta cgccgcctgg cggagctgcc
     6961 cggcacgagc gcggccatcc agcccggcga gtggggcgcg gcgctgggcc aggcgcgacg
     7021 actgcccgac tggaccgcgt acttccggca cgagctgacc gagcgcccgt ggcaggaagt
     7081 gctcgccgtg tggtggcccc ggctgctacc gggcatcgtg gccggctcga cccacggcgt
     7141 gatccgggtc agccacgcgg tgcgtacact gcgcggcacc gcttgcgccc cagcacgcca
     7201 gaccctcgac gagctggccc acgggctggc gttctgggcg gcgcgctacc gcgagctcgc
     7261 cggggtggtc gcgccggagg gcgccctcac accgcaacag gccctgacag ccgtcacccg
     7321 gctcaacgac caaagcggct tcatcgccca ccggctcgac cggctcgagc gcagcccggg
     7381 ctggactgcg agcctgcgcg cgctgaaacc cgccgcgtcc gccgaggagg tccccgcgcg
     7441 gctggagtcg ctcgtcgaca gcgccgccag ggcctacctc aggctcggcc acggctcgcc
     7501 ggtcctgctg gtccacgccg ctaccgcgcc caacgccgtg cggcacgtgc tcccggtcct
     7561 gccggccgag cagtggctgc cgagcctgac ggcggcctgg gcggccgtgg cggcggtcat
     7621 cgcgacgtac gccccggccc ggccggcccc gcacgcggag atcgtccggc gctatcccga
     7681 gctgacccgc gaggacacgc tccaacgggc ggctgagcac ggcgacgagc acgtcctgaa
     7741 gttcgccgac accgccgtcg agtcctacga ccgcaccggc gaccccgagc tgctcgccgc
     7801 gaccctgcac gtcggcgagc tgatcgaccg tccctgacgg gagaaaggtc agatccccac
     7861 gacgaccttg gcgcggacgt gcgcgacctc gaggtgatgg gtactccggc tccgcccact
     7921 cctacgtctg gcaggaagct cggaaacccg ccctcacgcc ggcccaggtc gcgtctccgc
     7981 gcatccgcat agacacgccg tgccgatgca ggtgtcggct gaccgtctgc cgcgcgattc
     8041 cgaaccgctc ggccagctcg tataccgtcg cgccggcttc ataggccgcg atgagctcct
     8101 gcacctgggt cttgttgagc ccgatctcat ccttcggtga gccgtcactc cccgtcccag
     8161 accgacaccg agcggcccgc gccggcccga catgcttggc tggaagtcgg gccgtggcgg
     8221 agcaggcagg ccaaacggag gcacccgccg agccgcagat cggatcgctt agcgcagccg
     8281 atcggcgcgg ccgatggtcg cggcatcgcg ctgggatcac tgcggggcgc ggcggggtag
     8341 gtcgctgatc tgggcctggg tcagctcgac ggcctcgcgt agcgaggcca cgtacgccga
     8401 gacgccggag cgatcgaacc ggaccgaggg aacggcgacg gtgaaggcgg cgacggcctt
     8461 gcccgccggg tcgcggatgg ccacgccgac gccgctcact ccctgctcgg tttcctcgtt
     8521 gttcatgccg tagccgcgcc tgcggacggt catgagctgg gtcttcagcg cggccagcgt
     8581 ggcgatcctg gcggtgggcc aaggcggtag gccgcccctg tgcagcacct ccaggtcggt
     8641 gttgctcaac tcggcaagca gggccttgcc cccggccgag cagtacgcgg gcatcaggtc
     8701 gccgacccgc acgccgaccc ggagcggggc gtcgcactcg attccgtcga tgaacttgat
     8761 gctccatcgt tgcagcacca tgagctggac ggtctcgccg acggcggcgt gcaggtggtc
     8821 gagcccggcc cgggccgtcg ccctgagctc gctcgtgctc agggcggtgt cgtgctgctg
     8881 actgatcgcc gggcccgcgc ggtaccggcg ttcccggtcc tggacggcga agccgcggta
     8941 gaccagcgcg ccgagcagcc ggtgcgcggt ggagggtgcg acggcgaggc gttccgccgc
     9001 ggccttgacg gtcagcagtt cgccgtgacg cagcatctcg accaggcgta gcgcccggtc
     9061 gaccgattcc agcggcgacc ccgactcgag ggtttccatc gctccctcta cgctgtgagc
     9121 cgaagcagcc ggatcgcgtt gtccttcatg attagcgacc gtacctcgtc attgatctcc
     9181 agcttgccga aatcggacag ccaccggtcc ggggtgagca gcggatagtc ggagccgaac
     9241 agcaccttgt gcttgagcag cgagttcgcc tgccggacga gctgcggcgg gaagtacttg
     9301 ggcgaccagc cactgaggtc gatgtagacg ttcggcttgt gcgtggcgat cgagatctgc
     9361 gcgtccaccc atggcacggc cgggtgggcc atgacgatgt ccaggccggg gaagtcggcc
     9421 gcgacgtcgt cgagcagcat cgggtcggcg taccgcagct tgatgccccg gccgccgggg
     9481 agtccgctgc cgatgccggt ctggccggtg tggaacagcg cgaccacccc cagctcctcc
     9541 agcgccgcgt acagcgggta gaactcggtg gagttcggct cgaacgcctg catgctggga
     9601 tggaacttga agccgcgcac gccgtactcc tcgaccaggc ggcgggcctg ggcgacggcg
     9661 gccgagccgc ggcgcgggtc cacggacccg aacgggatga gcacgtcggc gtgctccgcg
     9721 gcctgttcgg cgatctcctc gctggatagc gccgggtggt tcatcccggt tgaggcgtcc
     9781 acggtgaaga cgacggcggc catgttccgc tcgcggtagt aggaggccag ctcgtcgatg
     9841 gtcggcgtgc ggttgtcgcc ggacttgaag tacttcgcgg aggcggcgag cagttcgtcg
     9901 tcgagcgcga agtgccggtg gtcgcggtcg gcctcgatgt gggtgtgcac gtcgatggcc
     9961 acgacgccgg cgacgtcgat ggcgggttcg tagcgggtgg tcatgattct ccctgcgggt
    10021 gaatgcggtg ccgggcgagg tcggcgaagg cggtgagcgt gtcggggtcg gcgaccgcgt
    10081 ccatgttgac cacggcctga ggcgcctcgc cgcgcaggat gcgctttacc gggagttcca
    10141 gcttcttgcc ggtccgggtg tacgggacct tcgctagccg aaggatccgg tccgggacgt
    10201 gccggggcga gagcccggtg cggatcgtcc ggacgatcgt gtcccgcagc gtttcgtcga
    10261 gcggcccgcc ggcggagggg acgacgaaca gcagcagctc accggtgccg ccctccgggt
    10321 cttccaggtg gacgacgagg ctgtccgcga cgccgtcgat ctcctccact gcccggtaga
    10381 actcggcggt gccgaggcgt acgccgccgc ggttgagcgt ggcgtcggat cggccggtga
    10441 tcacgctgct gcccagctcg ctgaacctga tccagtcgcc gtgccgccac accccggggt
    10501 aggtgccgaa gtacgcgtcg cggtagcggc tgccgtcccg gtcgccccag aagccgaccg
    10561 gcatggacgg catcggcgag gtgatcacca gctcgcccag ctcgccgacc acgacgtcgc
    10621 ccttttcgtc gtacgccttg gcgtccacgc cgaggctggg gccggacatc tcgccgagcc
    10681 agaccggctg ctcggggctg ccctgcacga tgccggtgca cacgtcggtg ccaccgctgc
    10741 ccacgttgag cagcacgtcg tcgccgaact gctcgtggat ccaccggtag ccctccgcgg
    10801 ccagcgggct gccgaccgcg ccgatctgcc ggatgctgga caggtcgaag tcgcggcccg
    10861 ggttgagccc ggccttgcgg cacgccatca ggtacggcgg gctgatgccc atcagcgtcg
    10921 tccgggtgcg ctccgcgagc cgccactgga agttcaggtc cggatatgtc ggatcgccgt
    10981 cgatcaggac gaccgagctg cgggtcagca gcgcggagac cagcatgttc cacaccatcc
    11041 acgccgtggt ggagaaccac agcagccggt cgccaggctg gagatcccac tggagcgcgt
    11101 ggttcttcag gtgctccagc agcacgccgc cgtgaccgtg cacgatcggc ttgggcctgc
    11161 cggtcgtccc ggaggtgaac agcacacaca gcgggtggtc gaacggcacc ggctcgaacg
    11221 cgggctcgcc cggcgcgtcg cccggatcgc cgagcagctc cgcccaggac agcgtccccg
    11281 gcaggtcctg tgtaccgttc ggcacgtgca cgacgtgctt gagcgtcggc agcccggccc
    11341 tgatctcctc cacagccgcc ctgcggtcga tgtgcttggc gccgtaggtg tattcggaga
    11401 cggtgagcag cacagtcggc tcgatctgct cgaacctgtc cacgatgccg gctgggccga
    11461 actctggaga gcaactcgcc cacaccgcgc cgagaccggc ggtggccagg aacgccacca
    11521 tggtctccgg gatgttcggc aggtaggcca cgacccggtc gccccggcct acacccagcc
    11581 ggcgcaggcc cgcctgggcc ctggccacct gggcgcgcag gtcgccgaat gtcagctcca
    11641 tcggcggccg gttctgcgag tgggccacga tcgcgaccgt gtccgcgtcc tccggcaggc
    11701 cgaacgcgtg ctccgcgtag ttgagcgtgg ccccggggaa ccattcggca ccgggcatct
    11761 ccctgcggcc gagcaccttc tcgtacggtg tgtgcgcccg gaccccgaag tagtcccaga
    11821 tcgacgccca gaacccttcg aggtcggtga ccgaccagcg ccacagctcg tcccacccgg
    11881 agaaccgcag cccgcgctcg gtctccagcc agcgcaggta gcgctgcacg cccgactcgc
    11941 gggaggagtc gtacggtggg gacgtcagcg gttcgagacc cgcggcggcg gagcgggtgg
    12001 ccaggtccac cgtcgggtca gccatgacgg tgacctccgt gcccgtgacc gtcgcccgcc
    12061 ccggcgggcg tccgggctcc cgctccgatc gaaccgacga tccacgacat caggcccgtg
    12121 cccgcgtcga acgccggggc gcgtttgacc gagctccaca cggtctccgg gcggcactgg
    12181 agcagcacca ggttggcgtc ctgcggcagg tcctcgtcga cggcgaactc gatgtcctgc
    12241 ggcctgccct ggagctgttc gagcttgcgg ccgagcgcgg ccagggcaag cacctcgtgg
    12301 tcctccaggc agagccgttc cctgcggtcc tccggcaccg gcaccggccg gtcgcccctg
    12361 cggtactcca cccgcttgtc gcccaggaca cgctggtcca ggctgagccc caccttgttg
    12421 accacgtacc ggtcaggggt gacctcgccg ccgacgacgg acaagccgag gccccagctc
    12481 gattcgagga cgatcctgga ccggtcgccg gtgatcgggt cgagcgtgaa catgacgccc
    12541 gccgacctgg cccggacggt cttctgcacc acgaccgcca tctcgacggt ccgcaggtcg
    12601 atgccgcgct ccaccgcgta cgacaacacc cggccggtga agacgctcag atagcagcgg
    12661 tgcacgtggg ccagcacgtc ctcagcgccg accacgtcca cccaggtctc gaactccccg
    12721 gcgaagctgt cgccgccgga gtcctcggcg gtggcgctgg aacggacggc caccgggaca
    12781 tcgcccccgc cgatccgcgc gttcagctcg gcgtacgcgc ggcgcacctc gtcggcgacc
    12841 cgcgcaggca gcggcgcccg gctcagccgc tcggtcagcg cccgctccgc cgcgtcgtac
    12901 gtggaccggt cgtccggatc cacctggccg aggatgcgcc ggacgtcatc acgcagcccg
    12961 ttctcgtcca ggaagtcgcg gtaggcggcg gcggtcaccg tgaaaccggg tgcgaccggc
    13021 agcccggcgg cggtcatctc ggccaggccg agcgccttgc cgccgacctc gcgcacgtcg
    13081 cggcacgcct cggagtcgaa cggaaccgtg tagaccgtca ttcgcccgcc tcggtcagga
    13141 tcgtcacgac accggtttcg ccgtccaccc ggacccgctg accggtcttc agcctcgccg
    13201 tggcgaagcc ggtgcccacc acggcgggca ggccgtactc acggcagacg atggcggcat
    13261 ggctcatcat gccgccgatg tcggtgacca cgccgaccgc gacggagaac gccgccgccc
    13321 aggacggcgc ggtgatcggc gcgaccagga tctcgccggg ctggagcagc ccgaggtcgt
    13381 tctcggtgcg cagcacccgc accacgccct cgacggtgcc gggaccgccg gggatgccgg
    13441 tgagccgggc gtcgccgccg ctcgccgcgc ccagccactc ctgcacccgc tccgtggtga
    13501 cgccgtagtt catgacggcg aacgggtcgg tcacctgctc gggcgggatg ccgtaggcgg
    13561 ggggcgccac ctgactctgc agggcggcca tgatgccgcg gcggcggtcg atctcggcct
    13621 gccagcgctt ggagccgcgg gccgggacgc cgatcgccca ggactcgacg acgtcgaaca
    13681 ggacggtgtc cagctcgaag cggttcaggt agaacacgtc gtcacgctcc cgggtgaatc
    13741 cggccgacac cagcaggccg cccagctccc aggccttctc ccagaagacc gcgtgcgccc
    13801 agtgctcgac gtagatgttg tgctcctcga tgtacgggaa caccgtccgg gccaggttga
    13861 gcagctcgtc gaactggcgg gcctcctcct cggtgagcag cgcgcggtac tcggcgacca
    13921 gccggtcccg ctcctcgcgc agcctggcca ccgggcggct gatgtcctca ccggcctgga
    13981 gcttcgcgac gtaacgcgcg attccggtga gcggaatgga caggttgccc gcccaggtgt
    14041 cctggtcgtg ggtgaagccg tactcggcga agtagttgaa ccaggggtcc ttggccttct
    14101 cgaacgcctt cagccagacc tggccgttct cggtcccggc cagcgcgtcc agcagcgcgt
    14161 cggcggccga cgtggcggtg aacccggcga accggtcggc caggtccagc tcaccggcca
    14221 gcacggccag tcggcgcagc tcgtcgtccg gccggaacgc cagcacgtcc acgcccgcga
    14281 ccatccgggc cacgtcctgc tcgctgatct gcgggaacgc ctggcggcag aactggaaga
    14341 aagtgatgta accgccgtag ccgaggttga ggaactcgaa gtggtactgc cagaccagga
    14401 agaactcgtc gatcaggcgg tggtagttct cgatgacgtc ccacgacacc gaccggccgc
    14461 gggcctcggt gaccacctcg accgggtcca gctcgggcag cggcgtgaac ttcagggtcc
    14521 gcatggactc gatcgcggcc agcatcttct ctttccagcg gccgtacagc tcgtcccagt
    14581 tggcgtagta gtagcctgct cgctcctgga agaacgaggc ccgccgcccg atctcctccg
    14641 ggtcggtcac cgcgatcggc gagatgtaca catagccgtt gacaacccgc acgtccaggc
    14701 cgagcgaggt gggcagcacg aagatccggg tgctgttctg gccggccccc aggtagaccg
    14761 cctcggcgcc gatgctgtcg aacgggtgga ccccgcgcga ccagtgcatc gtgtcggcga
    14821 accagaaccg cgagttctcc tcctcacggg tctcctcgct cggcaccagg aagtacggat
    14881 acatcgactc ccagcccgca gcgccgtcgg gtgcctgggc ctcgttgaag aaggggaacc
    14941 tggagtgatc gttggcggtc atgccgtgac tccttcggac atggtgaggt gaggggtgag
    15001 gagccggtaa agctccgcga cgtcggcgta taccgcgtcc ggtcgttctt cctgtgacac
    15061 gccgtcgagc tgttccggtg tggtcgcccc gctgaggacg agaagggcgt gcgctcccat
    15121 gtgccgtgcc agacgtacct cgacgagggc gtcgccgacg acggcgacac ggcccggcgg
    15181 ccggccgagc cggtgggcca gagtcgcggc cagggcgggc gagggcttgc cgagcacccg
    15241 gggctcggcg ccggccaccc agccgatcgc gttggcgatc gccgcggagg cgcagatgga
    15301 cttgccgagc ccgccgtgga accagcggac gtccacggtg gtgtagagag gggcgcccgc
    15361 gtccaccgcg aggccggccg cgttcagttc ggccgtcccg tacgaccggg ccgcgccgac
    15421 cacgaccacg tcggccaggt cgcccgggtc ggccagcgcg acgcccaggc ggcgcagcgg
    15481 gtcgcgcagg ccctcctcgc cgacgacgag cacccgggcg ccggggtgct ccctggcgat
    15541 gaaatcggcg gcagcgctgc ccgcggtgac gaagtggtcg tcggcgatgt cgaaaccgtg
    15601 cgcgcgcagg tgctcggcgt acgtccccgg cggctgctcg gaggcgttgg tgcatatcac
    15661 cacctcgtgg ccggccgcct tcagtgcgga cacgaaccgc acggcgtccg gcatcggcgt
    15721 gccgcccgcg ccgcccgcgt gggcggtacg catcaggcag ccgtccacgt cgagcaccca
    15781 ggcgtcgatc gcgtgcagcg ggccggtcat cgggcctcct cgggggcgtt cctggtcagg
    15841 tcgagccggg tgtcgccgag ctggacggag accgtggtga gtctcggccg gtcctccacc
    15901 gaccgcagca ggttccggag cgtggacgcc ggtgaggaac cacgcgccgc gaccatggcg
    15961 tccacctgct cggcgggcat gaccgcgcgg agcagcagat cctcgtcgct ggtggtctcg
    16021 ccgaaccgct tgcgcagttc ggccagcgtg atgtcggagc tgccgtcgtc ggccggccgg
    16081 ctgccgcgct tggtgctgag cgcccggtcg agcaggtcct ggttcaccgg gccgggcagc
    16141 ggaccgaagt cgccgcgcag caggtccacg acctcgtcgg agatctgccg gtaccgctca
    16201 ccggtgatca cgttcagcgt ggcctgcgtc acgatgtact gggcgaacgg cgtcatgacg
    16261 atcggccagc ccaggtcctc ccggacccgt acggactcct cgatcacggc ggggaccagc
    16321 tcggggcggc ccagctcgcc gagctggcgc gccagggtgg actggacacc gcccgggatg
    16381 gtgtgccggt agtagtcctg gtcgtactcg gccgggactc cggcgggcag ccgcttgatt
    16441 ttggcctgcc tggtcaggta ggccgacgct cggtccatcg cgtcgaggtc cacgtccagc
    16501 cgatggccgc gggcacgcag gttgcggacc agccgctgcg cggcggggtg cgagttgccg
    16561 ttcgcgagcg gcggcagcgc gcagtggatc gtgtcgatcc cgtggtcggc ggcggtcagt
    16621 gcggtcagcg gggacagccc ggtcgtgctg tggctgtgca gctcgttcag ccgcagccgc
    16681 gacagcttcg actggagcat cggcaccagc gtggacagcc gctcgggggt gagcagcccg
    16741 gccgggtcct tgaggtagac gttgtcgatg tcggggcagc cgtccagctc ggcgatccgc
    16801 tcggcatagt agacgtcggt gtgcaccggg ctggtcgtgt agcagacgcc gcccacgatc
    16861 tcctcgaacc cggcgcgccg cgccatcgcg gccatccgct tggcgccggc catgtcgtgc
    16921 atcgggtcga tgatccacag cctggtcacc ccgttgcgta cgagcagccg gaaggccagc
    16981 tcgaacaggg cgtccggggt gcgatagaag gtgatgaacc gcttgccggt ggtgaggaag
    17041 ccgagcctgg tgttcggcat gcggtcgcgg gcggcgcgca gccgtgccca cgggtcctcc
    17101 ttgtggaacc gcacggcgac cgcgagcacc gtgctcgatg cgatctccac cgcccggtag
    17161 ccgacctggt cgagcagggg cgctacgccc tcgaccatcc tggtcgtcac gccgacggcg
    17221 ccccagaggc tctggttgcc gtcgcgcagc gatacgtcga tgagattgat gtccgtcatt
    17281 cactcgttcc gatcgccgag cagatcgttg taccggtcgt tcagccagtg cgtggtcacg
    17341 gtcccggcca ggaagtcccc gtgccgggtg atgctccgca gcaggtcgcg cgacgtggtg
    17401 acgccgccga tctcgaaggc ggccaacgcg gcgttcagcc gggccgctgc ggcggcccgg
    17461 tcggtgcccc aggcgacgag cttgcccatc agcgcgtcgt agaagggcgg gaaggcgtag
    17521 ccctcgtaga tgtgcgagtc gagtcgcagg ccgccgccaa cggggggccg ccaccgcgtg
    17581 accgtcccgg gggagggccg cagcaggtcg tacgggtcct gggcggtgat cctggcctcg
    17641 atcgcgtgcc cggtgagccg cacgtcctcc tggcggaccg agagcggctc gcccagcgcg
    17701 gcgaggagct gctcgcggac cagatccact ccggtgacgg cctcggtgac cgggtgctcc
    17761 acctggagcc gggggttgac ctccaggaag ttcagctcgt cgcggcgcac gtcgtacagg
    17821 aactcgaccg tgccgagccc gacgtagtcc agcgcgcgcg cgatccgcag cgcgctgtcg
    17881 tgcagccgct ccctggtggc ctgcggcagc gccgcgcagg gcgcctcctc gaccatcttc
    17941 tggtagcggt actgcaccga gcactcgcgc tcgcccaggt ggatccggtt gccgtgccgg
    18001 tcaccgagga tctgcacctc gacgtgcttg gcgtcggtga cgtaccgctc caggaagacc
    18061 gtgccgtcgc caaaggcggc ctcggcctcg gcggaggcca gcgcccatgc ctcggccagc
    18121 ccggcgtccg actcgaccag cttcatgccg cgcccgccgc cgccgtgcgc cgccttgatc
    18181 agcacggggt acccgatgcg ggcggccagc tcggccgcct cggcgacgga ggaggcgtag
    18241 ccgccggcgg agaccgggac gccgagggac tcggccagtt cgcgggccga gagcttgtcg
    18301 ccgagcgctt cgagcgcctc gggggacggc ccgacgaagg tcagcccgtt cgccgcgcac
    18361 tcccgggcga agtccggccg ctcggacagg aacccgtacc cggggtgcac ggcggtgcag
    18421 ccggtggaga cggcggtgtg cagcacggag gggatcgaca ggtagctgcc ggtggcgtgc
    18481 gggccgccga ggacgaccac ctgcccggcg cggcgcgcgg ccagcgtgtc gcggtcggcg
    18541 ctggagacgc cgagcacggt ctcgaagccg agccggtcgc acgcctcgat gatgcgcagg
    18601 gcgatctccc cgcggttggc gacgaagacc cgctgccgcg tacggtcggc ctgacggctc
    18661 atgctgccgg cctgacggcg aacagcgggc tgccgtactc gacgagttcg ccgtctccgg
    18721 cgaagacctt ggtcacctcg ccggagaccc cggcgggcac ggagttcatg agcttcatga
    18781 cctcgacgat gcacagcacc gagtcaggct cgaccttgtc gccgatctcg acgtatgggg
    18841 gctcgccggg cttgggggag cggtagaacg tgccgagcag cggggccgtg atcacgatct
    18901 cgccctcgtc cggttcagcg gccgcctggg ccggggcctt caggggggtc ttcgccgggt
    18961 tcttcagtgg ggcgggggcc gccgacgcgg gcgcggcctg caccggagcg cccggcactg
    19021 cggcgggtgg cgggacggtc ggtgcggcga ggtcgagcgg aacgttcccg tcacggctga
    19081 ctgtgatgcg aaggtcgccc ttctcaaacc tgaagtgccg gaaatctgcc ttgtccagca
    19141 gctcgatgat cgaggcgagt tcctcaagat cgaagtccat cggtgccgac tccattgccc
    19201 gaattgtcgt cgtagttacg gtgaagttac gtttgctctc catcaggcgc aacgaagtat
    19261 cggtaaattc tcctgagcgg aatctgcagc ctaagagccc ctaacagaat gatctccgtt
    19321 gtggtttgat ctctcgtgct agtcggcgag aggagtggca ggtggcacgg ctgaagccgt
    19381 gggaggtcag cgacgagtta tgggcggtca tcgagccgtt gctgcccaag catcagcgcc
    19441 ggagccgcta tccggggcgc aagcggctgg atgaccgcct ggtcctgcag ggcatcttgt
    19501 tcgtcctgca caccggcatc ggctgggagc acctgccgca ggagctgggc tacggctcgg
    19561 gcatgacctg ctggcgacgg ctggccgagt ggcagaaggc cggagtgtgg cagcgcctgc
    19621 acgaggtgtt gctcgatcgc ctccgcgccg ccgacgcact cgacttctcc cgcgctgtcg
    19681 tggactcctc ccacgtcaga gcgttaaaag gcgggcgcag accggcccaa gcccggtcga
    19741 tcgaggccgc ccgggcagca agcaccacct ggtcaccgac gccaccggca tcccgctggc
    19801 attcaccctc accggtggca accgcaacga cgtcacccag ctcgtccccg cgcgctgcgt
    19861 ccaggttgag gtggccagtc agggccggac ggttgacgag gccctggccg gcctccgcga
    19921 cgctctggag ctctacttcg aggacgagcc tcttccccag accccgcagc agccgatcgt
    19981 ggcgccgatc gagatccgtc gctcggcacg agcccgcgcc agtttcggtc tgctccggca
    20041 ccgacgtcgt gcgcgcgctg gagaagtgtg gctttgaggt ggtggccacc ctgctgtgat
    20101 cacggggccg tgccgcgttc cgtcggcagt ccctgtcacc tgtgcacgac ggaccattgg
    20161 gtgacgaact gagtgacaac gaccacggac gcccctagaa ccgtacggac gtccgtggac
    20221 ggtcggccca ggtcaatgcc actttcatgg cacgtcggcg atacgtccaa gtggacatct
    20281 gctcgtgccc gaggatgcgc gccacggcgt agccgggatt gtgatgccct acgtcggatg
    20341 gaacgtcagt cgtgagggct accttcactc actatgagtg cccagtacgc atggcctgaa
    20401 ctcttccctg caaggcatca ggtgaccgac ggttctgacc acccggcggt cagtccactc
    20461 ggcgatctgt tctccccggc taccgaagca gaggtccgcg agcttgaaga gcggctgggt
    20521 gtggagctgc cgccgagtta ccggcagttt ctcctgtccg ccaacgggtg gggcagcgac
    20581 gatgactgct gcctgctgcg tgtcgaagaa gtcggctggc tccgcgatgt cgatccctcg
    20641 atcgccgaga gctggtcggc acccaagccg gagaactcat ggagcgtgcc cgacgagctc
    20701 tacttcgtct acggactgga gcaggactcc atccatttca gaggggagta tgtgcccgac
    20761 accctgctgc tcggatactg ggatgacgga gcggcgctcc tcaatcccca cgtcagcacc
    20821 gttgaaggtg agtgggaagc ctggtatctc gcgccgtggc tgcctggcgc caggcgctac
    20881 aggtccttct gggacctcgc tatggaccaa ctgaggatgg gcgtcaaccg gattcgctag
    20941 tgctggacag ggcggcctcg tctacgacgt tgcccctgcg agcagtgtcg ggaacctggt
    21001 tcgcgtcaca gtcctcaaag ctgacagctt ggatccgatg ctgatccacc agcgggtggc
    21061 ggtgaccacc tgggaccagg cagacattcg caatgtgtgg gcaacggcgg tggtggtggt
    21121 tctttcgtgc cggtggagaa acctaggaga tcgcgagggg tgccctgttc ctaccagcgg
    21181 taccctccat acggcctttc cgcggtcgtg gtgtgaccct ggtatcggcc tcggcccgcg
    21241 tcgaccgaag gccagaccgc tcagcttccc cagacgccga cggtctcgcc cgaggcgacg
    21301 gcggcgtcct tgatctgctg gtgcgtcgac ttcgcgtcgc cgctcggtgc gacgggaccg
    21361 cgcagggcgt acacgatgaa gtggtagtgg tgaacgccgc tcggcgggca ggggcccgcg
    21421 taggcggcct ggccgtcgct gcccggcagc accttcccct gggtctgccc ctcgctcacg
    21481 ctcgtcgccg agaccgggat gcccgtcacg atccagtgga tgtacgtccc gccaggggcg
    21541 tcggggtcgt ccaccacgat cgccagctcg cgtgcggact cgggaacgcc ggtccaggtg
    21601 agcggaggtg agacgttctc accgccctgc tgcgtgcaca cgtacttctc ggggatctcg
    21661 gcgctctcgg cgaacgccgg gctgctcacc ttgagaccgt cggtgggtga ggcgtctccg
    21721 gcgttcccgg gtgcgcaccc ggtcagcaga aggatgacgg cgccggccac cacgcgcttg
    21781 ccgagcttca cccgcccagg ataagcggcc ggaggccggc aactacggcg ttcgtccccc
    21841 atgtcggcga actcatccgg cacgccgaga gcgggcggcg cggctgagcg gccggtctgg
    21901 ccgagctgtc aaaggtcggc cttttcaatc cctcccttcg gtatttatca gcatctcggg
    21961 cgcattgatc agataggcgc ggtgaggatc ggggtgcaag cgccgtcgcg taggtgcgcc
    22021 cgggagggat gacgggggtc aaccctcgca cgacagggct tcgtccggag gggacagaag
    22081 gcggtctccc gatcgcgaga ccgccggatc gggggaaacc aatgcgcaag atgctcacga
    22141 gcctggggct ggccttcctg ctcacgcttg ccccggccgc ggccgccacg gcggagacgc
    22201 ccgtcgcgcc ggccacgtac agccagccca atccgtcacc gcaacccggc cagggcaggg
    22261 acggtggcgg caacggaggc ctgtggggtc tgctgggcct gctcggtctg ctcggtctcg
    22321 ccggtgtgcg caagcagaag caccgcgtgg gcacggccga gcacatgtcc aaccgtccgt
    22381 acagctgagg ccctccgtgg cgcgtgtccc cgcggcggcc cgccgcgggg acaccgccgc
    22441 gttcggcggc ccactggcag gtttggccct cctaccagcg ggtacggcgc gcggactgct
    22501 cgtaaccgct tgatggagga atcgcacgat ggatgccagc aagcccgcca aggcggtcaa
    22561 ggaggtcgtg gagaacgcag cggagaaggt gactgacttc ctgacgccgg acgtgcccgg
    22621 ctcgccgggc agcgccccgg cgaccgtgga ggagccgacg acgccgcgtg acccgctgcc
    22681 cccgaagaag gagcagggcg ctcccgcgac cgtcacgccg accggagcgg agaccggcgc
    22741 gcccgccacg gccaagggac agcagggcgc ccacctcacc accgcgcagg gggcgcggct
    22801 gcgcgacacc gaccactcgc tgaaggcggg cgagcgcggc cctaccctgc tgcaggacca
    22861 ccatctgcgc gagaagatca cgcacttcga ccacgagcgc atccccgagc gtgtcgtcca
    22921 cgcccggggc gccggcgccc acggcgtttt cgaggcgtac ggcaccgccg aagcggtgac
    22981 cagggccggt ttcctgaaga aggggaagaa gaccgacgtc ttcgtgcggt tctccacggt
    23041 cctcggttcg cggggatcgg ccgacacggt ccgcgacacc cgcgggttcg ccacgaagtt
    23101 ctacaccgac gagggcacct tcgacctcgt cgccaacaac atgccggtct tcttcatcca
    23161 ggacggcatc aagtttcccg acgtcatcca cgcgggcaag ccgcacccgg accgggagat
    23221 cccgcaggcg cagagcgcgc acgacacgtt ctgggacttc gtctcgctgc acaccgaggc
    23281 gcagcaccac accatgtgga acatgtccga ccgcgggatc ccgcgctcct tccggatgat
    23341 ggagggcttc ggcgtccaca ccttccggct ggtcaacgag gccggggaga cggtgctggt
    23401 caagttccac tggaagccca agctcggcgt gcactccctg acctgggagg aggcgcagat
    23461 gctcggcggc atggaccccg acttccaccg ccgcgacctc tacgacgcga tcgaggccgg
    23521 cgcctaccct gagtgggagc tcggcatcca ggtcctcccc gacactcctg accagacgtt
    23581 cgagggcatc gacctgctcg acccgaccaa gatcgtgcct gaggagctcg cgccggtgca
    23641 gcccatcggg aggatgacgc tcgaccggac gcccacgaac ttcttcggcg aggtcgagca
    23701 ggtcgccttc cacgtcgggc acctgccgcc gggcatcgac gtcaccaatg acccgctgct
    23761 gcagacgcgg ctgttctcct atctcgacac gcagatcacg cggctgggcg gcccgaactt
    23821 cgcgcagatc ccgatcaacc gtccgcactg cccggtcaac gacatgctcc gcgacggctt
    23881 ccaccagcac gccgtccacg ccggcgtcgc gccgtaccgg ccgaactccc tggacggcgg
    23941 caacccgttc gtcgccggcg acggcgagaa ggcgtacacc gacgtgccgg tcgaggtcgc
    24001 gcaggcgagg aaggtccgtg ccaaccccgt gtccttcgac gaccacttca gccagacgcg
    24061 cctgttctgg ctgagcatga cgccggtgga gaaggagcac atcatccgcg cctacacctt
    24121 cgagctgggc aagtgctacg agcaggcgat caaggagcgt cagctccagt gcctggcgaa
    24181 catcgacccg gtcctctgcc gggaggtcgc caccgggctg ggccttcccg cgccggagcc
    24241 ggccctgccg ctcgccgacc cggcgcccag ccccgcgctc tcgcaggtgg gcaaggagtg
    24301 gccgggtgac ggccgcatgg tcggcatcgt ggtcgacgac ggcgccgacc tcgacggcgt
    24361 acgcgacctg cgcaaggccg tgttcgccgc cgggatggtg ccgctgctga tcgcgccgca
    24421 cggcggcacg ctgggagaca tgcccgtgca gcggaccttc gccaccgccc ggtcgatcga
    24481 gttcgacgcg ctgctgctgg cggccgcgcc cgtgccggcg cccgacgcgc tgcccgcgcg
    24541 cgacgccaag gcgggagcgg gcgatgccac cgtggtggac ccgcgggtca tgctcatgat
    24601 cgacgagtgc tggcggcacg cgaaggcgat cggcgcgtgg ggcggcggcg cgaaactgct
    24661 cgcgcaggcc gggatcaccg gcacgccggg cgtggtctcc ggtgactccg ccaccgaggt
    24721 gttcaccgca gtgcagcggt cgatggccgc ccaccgcgtc tgggagaggt tccccgcctc
    24781 ggtcgcctga cgggtccgcg tcaggcggcg aggcgcgggt cgcccactcc gcgcagtctc
    24841 cacacggcct cctcccttga tcgccgccgg gggaggaggc cgtggtgagg agcccggcgg
    24901 atgggtagtg ggagacagtg caccgatccc gcgaatccgg acgtcgacga gctcgtgatt
    24961 cacggtcgcg gccgttgtga acgagagccg gccctccggc atcgcgtgcc ggagggccgg
    25021 gtgctcggcg gtgagccggt cgctaccagg tgatcggcat cgtcgtcagg ccgtgtacga
    25081 cggtgaggga gcggaacagg ggctcgcccg ccaaccgcag gccggggaac cggcgcagca
    25141 gggcggggaa cgcgatgtgc atctccatgc gggccagggg agcaccgaga cagtgatgga
    25201 cgccgtgtcc gaacgcgacg tggccgatgg catcccggcg gatgtccagg tcgtccgggt
    25261 tcgggacgag ccccgggtcg cggttggcgg cgggcaggga gcagatgacg gtctcgccgg
    25321 ggccgagggt ccgatcgccc agccggacct cggacgtagt gatcttgacc gtcccggagt
    25381 gcacgatgct cagccaccgc agcagttcct cgacggcggc gcccacgcgg tccggctcgt
    25441 cgcggagcag cgtgagctgg ccggggtgcc gcagcagggc gagtgtgccc aaagacagca
    25501 tgttggccgt ggtctcgtgc ccggcgagca gcagcagggt gccgatgccg gtgagttcgg
    25561 cgtcgctcaa ctcgtcgccg tgctcgcgta cgagcatgcc gagcaggtca tcaccgggat
    25621 cggtccgcat cctctcgatc aggcctgcga tgtacgcccg ggcctccgcc gccgcggccg
    25681 cgcgttcgtc cggagacagg gacacgtcca ggatccgttt ggacgtcccc tggaagccgg
    25741 cccggtcggc gtacggcacg cccagcagtt cgcagatcac cagggaggga accgggaggg
    25801 cgaagtccgt caccaggtcg gcgggtggtc cgccgcgctc catggcgtcg agatggtcgt
    25861 cgacgatctg ctggactctg ggctccagcc gccgcatccg gcggacggtg aactgggccg
    25921 tgagcatccg gcgcagccgg gtgtgctcgg gcgggtcgga gccgagcagg ttgccggcgc
    25981 gcatcgcggc ggcctcctcc gcactgggcg gcggcgcgcc gggcggccgg agcggaggca
    26041 cgagcgcgtt gctgtacagc tcgggatggc tcagcaccgt acggacatcc tcgaacctgg
    26101 tgaccagcca ggcgtcggtg ccgaacacgg tgcggatccg ggcgaccccc tcgtcgttcc
    26161 gcagcgcgga gagctctggg acgggatgga atccgtccct tcgcatgtgc aggggcgggg
    26221 acatgtcgcg cacgcgatct cctcgggtca ccggcagtct gatgatcacc ttgccatgat
    26281 ccgacgataa ccgtcaggtg cccgccgtgg acggtcgtga cgcgatttcg gcggcggcgc
    26341 cccatgccgt tcggccgggc ggccgcgtgt cagggcgcga gcccggccag ggcggcgctg
    26401 tagatctcga cggcctcctc gatccggtgg accaggcagt attcgtcggt gacgtgcgcc
    26461 tgctcgggct cgcccgggcc gcagatgacc gtgggacccc cgccgcaggc ggtggcgagg
    26521 accgaggcgt cggtgaagta gctggccgcc ggctggtcgc caggagcgcc cgcccccgcg
    26581 tcgaccaggg cccgcacgaa ggggtcgtcc ggctccgtcc agatcgcggg caggtccacg
    26641 agcacgtcga gggtcgcctc gtcgccgagc gcggtctgca accgctcgcg gagccgtccg
    26701 tggtcctggc cggcgacggt ccgcaggtcg atggtcgcgg cggccaggtc gggcacggag
    26761 ttcacgttga tcccgccgcg caccgtcccc acgttcaccg tggacgggcc gagccagggg
    26821 tgatcgggca ccccgggatc gaaccgctcg acggcgccga taacccgggc gagcttgtag
    26881 atcgcgttgt cgccgaggtg cggcatcgag ccgtgcgccg tcctgcctcg cgtggtggcc
    26941 tccagccaga gcgcgccctt gtgcccgagc agcacccggt tggcggtcgg ctcggccacc
    27001 agcagcgcgc gcgacctgcc caccaggccc gcggccgcca tgccggccgc gccgtcacag
    27061 ccggtctcct cgccggcggt gaggacgacc tccagcgcga ccttcgcccc ggcgcggcgc
    27121 acgtgccgct cggcagcgac caccagcgcg gccaccccgg ccttcatgtc gctcgaacca
    27181 cgtccgtaca gccggtcgcc gtcgatctcc gcgccgtgcg gcgcgtgccg ccacgcctgc
    27241 ccgcccagcg gcaccgtgtc gagatgcccg gtcagcgtc
//
