LOCUS       NZ_JABBXA010000002     23213 bp    DNA     linear   CON 07-NOV-2024
DEFINITION  Microbispora sp. H13382 NODE_2, whole genome shotgun sequence.
ACCESSION   NZ_JABBXA010000002
VERSION     NZ_JABBXA010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora sp. H13382
  ORGANISM  Microbispora sp. H13382
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 798438)
  AUTHORS   Liu,C.
  TITLE     Selective isolation, identification and anti-microbial activity
            study of Microbispora
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 798438)
  AUTHORS   Liu,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-APR-2020) Microbiological Resources Collection Center,
            Sichuan Industrial Institute of Antibiotics, 168 Huaguan Road,
            Chengdu, Sichuan 610052, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014161445.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 07:22:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,982
            CDSs (total)                      :: 7,906
            Genes (coding)                    :: 7,786
            CDSs (with protein)               :: 7,786
            Genes (RNA)                       :: 76
            rRNAs                             :: 3, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 3 (16S, 23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 21 of 121
            Pseudo Genes (incomplete)         :: 104 of 121
            Pseudo Genes (internal stop)      :: 8 of 121
            Pseudo Genes (multiple problems)  :: 11 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:45:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 492551
            Orig. end                         :: 515764
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABBXA010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23213
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23213
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23213
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13213](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13213)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(46..846)
                     /locus_tag="HHX41_RS40230"
     CDS             complement(46..846)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023726.5"
                     /locus_tag="HHX41_RS40230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3631 domain-containing protein"
                     /protein_id="WP_259400652.1"
                     /transl_table=11
                     /translation="MPLEDRAADTWEPLVIAADHAGAHWSDRARAAALALTAEADDNGQ
                     TSTRIRLLADCRTAFGADTALPAAVLLERLKADPESGWADFGPTGLTPMKLGTIRREYD
                     IRPATIRFASGQAKGYHRGNFANAWERYCPTAEPLPEAAVVPIGRGSRTSRTSINTSKN
                     EAGTAGTAHPLQTAHPHPPSIAPASRTRSRWLPSACSTPSPRTGEVRGPCRGKVLGRIT
                     RRQRLTAGHSRTLSTDPNAEKPRSSADDPGFRVARPRGLESLTF"
     gene            860..1195
                     /locus_tag="HHX41_RS40235"
     CDS             860..1195
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="HHX41_RS40235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_396794098.1"
                     /transl_table=11
                     /translation="MLLSPEITRRLIDRYTAMAPPVNAPGLAHLTGREAEVLRLMARGL
                     SNREIAGELFLGEATVKTHVNRILAKLGVRDRVQAVVLAYEAGVVRASTRGPHIRILLT
                     TALDDHR"
     gene            complement(1272..1745)
                     /locus_tag="HHX41_RS06260"
     CDS             complement(1272..1745)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892854.1"
                     /locus_tag="HHX41_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_182905141.1"
                     /transl_table=11
                     /translation="MTDVRWLNESEMAAWLEFVSASHLLERLIEEQLKEASDLTHPQYE
                     ILVHLADAPDWQLRMSELARRVVITKSGLTYQIGRLEKRGLVERRRCDSDDRGILAALT
                     DKGMACLKSTAPGHVKVVRQNLIDVLDPDELAVIARAMAKVRHAHGHHEHTGH"
     gene            1824..2258
                     /locus_tag="HHX41_RS06265"
     CDS             1824..2258
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892853.1"
                     /locus_tag="HHX41_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DoxX family protein"
                     /protein_id="WP_182905142.1"
                     /transl_table=11
                     /translation="MIHKFRPVALLLARVAVGVIFIAYGWQKLFVNGVAGTTQFFESIG
                     APIPAVTAPLVGLLEAVGGAALVLGALLPVAGTLLALNMIGAIILVHGANGLYVDKGGY
                     EFVLALAAAALAIGFTGGGMLAVDDLWKRRGSEKLAATAH"
     misc_feature    1873..1887
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.24"
                     /tool="antismash"
     CDS             complement(2307..2468)
                     /gene="allorf_494858_495019"
                     /locus_tag="allorf_494858_495019"
                     /protein_id="allorf_494858_495019"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MARRSLHLDAVAAARVDRFRPPPAATAALTRSGVLPACQASRWRP
                     DEGTPDQG"
     CDS_motif       complement(2427..2468)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MARRSLHLDAVAAA"
                     /locus_tag="allorf_494858_495019_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(2307..2426)
                     /prepeptide="core"
                     /locus_tag="allorf_494858_495019_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.70"
                     /molecular_weight="4114.5"
                     /monoisotopic_mass="4112.1"
                     /core_sequence="RVDRFRPPPAATAALTRSGVLPACQASRWRPDEGTPDQG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MARRSLHLDAVAAA"
                     /leader_location="[2426:2468](-)"
                     /alternative_weights="4132.6"
                     /alternative_weights="4150.6"
                     /alternative_weights="4168.6"
                     /alternative_weights="4186.6"
     misc_feature    2674..2689
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.21"
                     /tool="antismash"
     gene            2746..3591
                     /locus_tag="HHX41_RS06270"
     CDS             2746..3591
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545531.1"
                     /locus_tag="HHX41_RS06270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_182905143.1"
                     /transl_table=11
                     /translation="MKLPACAAALGAAALLACLTGAFGMSAAQAADARALPSVNMEATV
                     KAAQIDPRRSDDTLTPGAKASVLLVERALRDRHLLDAKWVDGYFGTTTVVAFAKFQRSL
                     GLTGLAANGLPGRASLTRLGAGRFTVTHIIGAGARVSAGGVVIDTRTRSMLVEAKRLLG
                     RDLVLLQGSYNRGGDPTSAGTHDGGGVVDISVKGMNSVTRIAVVRALRRVGFAAWLRSP
                     DQADWPWHIHAAAINDTDLSSQAQHQIGDYYLGLNGLAGRGPDDGPKVTTRTWEEYQRR
                     "
     gene            3633..4529
                     /locus_tag="HHX41_RS06275"
     CDS             3633..4529
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013700.5"
                     /locus_tag="HHX41_RS06275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidase inhibitor family I36 protein"
                     /protein_id="WP_182905144.1"
                     /transl_table=11
                     /translation="MGTLDKILATAAAAMVLGGAVLATASPASAATRNGVCETGEFCYY
                     FNSNNQGSLSDFTGSVGGYGTEQPSCFDFKGPGTGKGKCVKNAAASVWNRSGKTVRVYF
                     NSNYGGSVYQDFAPGAKGNLKPGLKNQNASHQFGPSSSARVNMSYALYQTGGGYISCGF
                     DGYVHTSGRHEGIDIKRSEGSDVHALVSGQIINVVHGRNGGSGLSTIAIYNASLNKTII
                     YLHSAPLSSLRVGQQIARGQIIADEAWHGVSSRSAAHTHVEMRPGRQKLAAKSVRDPNL
                     SNPNPNSFWNSQGYNVR"
     gene            4563..5513
                     /locus_tag="HHX41_RS06280"
     CDS             4563..5513
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020075.5"
                     /locus_tag="HHX41_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SpoIID/LytB domain-containing protein"
                     /protein_id="WP_182905145.1"
                     /transl_table=11
                     /translation="MSPRTARLISRPAAAAAALVVGAAVLATASPASAATRNGVCETGE
                     FCYYFNSNNQGSVSDFTGSVGDYGTRQPSCYDFKGPGTGKGKCVKNAAASVWNRSGKTV
                     RVYFNSNYGGSVYQDFAPGAKGNLKPGLKNQNASHRFLSSAPPTGCKTDGTDSRLPTTI
                     LVYRESLNRVDRVEFKTYIKNVLPNEWRSHWPRESLRAGAIAVKNFGWYWALRSASKTP
                     SGQCYDVTDHTSSQMYKPGSATAATNAAVDATWGIRMTRNGKIFKAQYCSTTTACRHWV
                     TGDWMSQNGSRDKAEAGWSYSRILRYYYKGIALTS"
     gene            complement(5573..6613)
                     /locus_tag="HHX41_RS06285"
     CDS             complement(5573..6613)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF027484.5"
                     /locus_tag="HHX41_RS06285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NBR1-Ig-like domain-containing protein"
                     /protein_id="WP_259400738.1"
                     /transl_table=11
                     /translation="MPARAEAIEDFAAALRELRKSVGNPPFREMSGRSGAISHTTLHEA
                     TKGNRLPSWETTVEFVKACGADSAAYRERWERANLAVRSASAGDPSSRAGTLRAGPPDG
                     LEASATDIAEDRAVPGATGPQAPRPAGVAPASPPTPPPHEIAGDVQPVPSVPGGRGRFR
                     PTRPAAAALAVAAAGVAAVVLIAVAVNRGSGTDGHNVNPSESASKTGLSAADCPVRATN
                     PPWSPPVHEGDSAKFIGDITLPDCTRVGPRQTVTKVWRLKNAGTVPWKGYSLHRIDLPQ
                     QPDQCQTVPDIPIKDTRPGEMVDIRTDITTPTKPGLCYVRFKMMEGSGRVAFPGGRPLN
                     FQVIVG"
     misc_feature    complement(6374..6376)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6779..7996)
                     /locus_tag="HHX41_RS06290"
     CDS             complement(6779..7996)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892674.1"
                     /locus_tag="HHX41_RS06290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase"
                     /protein_id="WP_182905147.1"
                     /transl_table=11
                     /translation="MILASVLGAAACGPAATRTAAPQPYDQSRLQRDADAITATGATGV
                     QARATRDSHNLVATSGFGDTGTRRPVKPDDHFRIGSSTKTFVATVVLQLAGEGKLSLDD
                     TVERRLPGVVHGNGNDGSKITVRQLLQHTSGIHEGDEGQETPADYYRHRFDIVPPDALV
                     KEAMRHRPDFAPGMSWRYCNAGYVLLGMIIKRVTGRPWSEEVDRRILRPLGLRNTSVPG
                     LSPDVPDPHSEGYDRYPDGTLIDVTRTRAPYTADAAGAIISTTADLDRFYRALLSGRLL
                     RPAELDQMKRTVATDAEVRQAFPGARYGLGLFSIPLSCGGNYWGHGGDIVGFMTRNGFT
                     EDGRRGVVVSVSTENANSEDRSLRQIGAASTLIDHALCGTGSIPRPPAESSFRPGRAAV
                     WRSSSS"
     gene            complement(8091..8945)
                     /locus_tag="HHX41_RS06295"
     CDS             complement(8091..8945)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017597532.1"
                     /locus_tag="HHX41_RS06295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_182905148.1"
                     /transl_table=11
                     /translation="MAGGTVPRAAYGRGLAAELVAARMVWRREMLHFLRDRVGTLVSLV
                     ESLMFLFILGIGLGGLFAASGAGSASDYLTFFFPGVLVMAAQPAAMSVGASIVWEREDG
                     FLREMLVAPVSRSTLLIGKCLGGMTVATCHGMVILASAGLLHVPYRPAAFAMLAAELAL
                     TSFALTVLAAAVAVFVRRPRTLTTVLSVLMAPLMFLSGTMFPISALPGWLAWLSRLDPL
                     TYAVDAMRHTTGIVRFPRGRAMLSQPLSWGDLRLSPPAEMAVVAALTVITLVVAARRFS
                     RLG"
     gene            complement(8945..9940)
                     /locus_tag="HHX41_RS06300"
     CDS             complement(8945..9940)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012850764.1"
                     /locus_tag="HHX41_RS06300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_182905149.1"
                     /transl_table=11
                     /translation="MFGTGHRSAQAPPTARRCQGVPAIRATGLHKSYPDVDAVRGVDLT
                     VEQGETFGLLGPNGAGKSTIIAMLCTLAVPTAGRIEVAGHDTRTAPGPVRRSLGIVFQE
                     STLDGELTAAENLRFHADLYAMPKAGLAARIDAMLDLAGLTARRDHLVRTFSGGMRRRL
                     EIARGLLHRPRVLFLDEPTIGLDPQARDRLWAHLCEVRERETITIFLTTHYLDEAERCD
                     RIAIVDDGRIVAQGTPAELKSTLAADRIDLRTGDDVAAAATLRERFGIEAVAGPRGLRV
                     QAENGARLVPRLCAGLDVPVHELTVTRPSLDDVFLHHTGHHIRDEPGGGR"
     gene            complement(10001..13213)
                     /locus_tag="HHX41_RS06305"
     CDS             complement(10001..13213)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="HHX41_RS06305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_182905150.1"
                     /sec_met_domain="DUF4135 (E-value: 6.6e-69, bitscore:
                     228.4, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.4e-61, bitscore:
                     203.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDHHSFVDIAAAAANLAERLRILAGLEATGPATFADPLPRFDAW
                     KIDRISQRLAVKTDVRAPDPSAPAAPGRDDLRRALTAFRHHELGLRDADDDTKAVFAEV
                     QRSWLPTYQAALGGFDRSAQDAQDASWRRPEIYYGRLAIACEPFLLELGRRMDAARACH
                     PGRFSRRMTDDLQRHLFERFELSLAWAVEADAKVHCAEAGIDRARATREDFRAYLDATF
                     AEAADHHRFHLGFPVLGRWLAHITALLADFGCELVERLEADAAAIGQTIFGEDISSFLS
                     LRPGISDHHAGARTVALVEARLVSGATGSFVYKPRSIAAEATMQKLLARLRDDGVLDFA
                     PYAVLPRPGYGYEERIPPGRNHVTTREEVERLYRELGGHLGIFYVLGGDDLHLENVLVA
                     DGHAHVCDCETALSVLLRGQARPPGTLLDSVFRTGLLEWPRAAGSGDLMRASGYSGGEA
                     YELPMPVPCLEERRDSFRTSVTHMTGVRVEPGTHNRVLVGDTVVRPEDFTEAIMEGFGR
                     VHEWFERRPDAAVRAVTEMFGGVSVRFVNWATQLYVNLLQHARHPRCLVDPLEVDLTLG
                     TVRTFLQSWDRDGRLAEREVESMWRLDIPIFTMDARGGPLIHDHTTPLAIDLDTSPLGC
                     AAQRIRSLSVDNRERQRRYIAAGLRTSEVASPAFVSAAAEQASRVGERLCAMLREPSEP
                     APWTSYEISPDGPVRVDIGGDLYDGAAGIALFLAYLDQIVPRPEFRRAAERALSHAVAA
                     TDRRQIGAFTGVGGLIYLLTHLHRLWRDRELLGLAVRLSEDLRSRIEADTALDVFSGAA
                     GLIPVLLGLASEADGEGVDQAHLCARVLLRRAVADAGTLSWPPPDPRIAPANLTGFAHG
                     AAGIGWALIRLGRLTDRTEYVIAGRRALAYEARHFDETTNDWYDLRTSPGGVLQDGRYY
                     ANAWCNGAAGIGLSRIASWALLDGDDESLLRDTHHALTATLRNFPRLRNDTLCHGRSGN
                     AELFLRFARLHDEPTFRLEANVQAHEQWRHFDDTQNGLIQDTAGFFPGLMIGRSGLGMH
                     FLRLAHPDRVPSPLLLDPVPGG"
     misc_feature    complement(11966..11968)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13487..13714)
                     /locus_tag="HHX41_RS06310"
     CDS             complement(13487..13714)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_169985488.1"
                     /locus_tag="HHX41_RS06310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cinnamycin family lantibiotic"
                     /protein_id="WP_169985488.1"
                     /transl_table=11
                     /translation="MDRMMALQATVDDEFRAELMTDPIAFDTEVSALPDPIEQPDQESL
                     RSWTTGAASEIYACPATHHCIHTHVCRKTY"
     CDS_motif       complement(13541..13714)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MDRMMALQATVDDEFRAELMTDPIAFDTEVSALPDPIEQPDQESLRSWTTGAASEIYA"
                     /locus_tag="HHX41_RS06310_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13487..13540)
                     /prepeptide="core"
                     /locus_tag="HHX41_RS06310_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.80"
                     /molecular_weight="1953.3"
                     /monoisotopic_mass="1951.9"
                     /core_sequence="CPATHHCIHTHVCRKTY"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDRMMALQATVDDEFRAELMTDPIAFDTEVSALPDPIEQPD
                     QESLRSWTTGAASEIYA"
                     /leader_location="[13540:13714](-)"
     misc_feature    complement(13616..13618)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14160..15209
                     /locus_tag="HHX41_RS06315"
     CDS             14160..15209
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020544816.1"
                     /locus_tag="HHX41_RS06315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_310741800.1"
                     /transl_table=11
                     /translation="MLAEAVRQNHYPGALAQAWSRERTSDVAIGVGDVRNGTAPRPDAR
                     FRAGSITKTFVATAVLQLVAEDRLRLDDTVEHWLPGLVDGKGNDGRRITLRMLLNHTSG
                     LFDYTTDKELGQAYERDPSRRLVPRALVRVAVSHPPLFPPGAAWNYSDTDYVLLGMVIQ
                     RVTGRPYTEEITRRIIRPLGLRSTYFPGGSSSIAPPYLHGYTMSDSGAVKDATVLNTSF
                     APGSGDLISTVGDLNRFASALLAGRLLPQPVLRQMLTPVPGSRAGSDIDEYGLGVIITK
                     LPCGITVYGHGGTLDGYLTGVTGRSGGTHTLAWVINGSWGVENQIALMDKAYIAEFCGS
                     RQPPRRVWE"
     gene            complement(15301..16836)
                     /locus_tag="HHX41_RS06320"
     CDS             complement(15301..16836)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.5"
                     /locus_tag="HHX41_RS06320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_182905151.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6e-45, bitscore:
                     149.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHALPKRRLAATAAAFAMVGAAFLGGATGSASAATTDEPTSTPV
                     NVDIPDGMLMSYVVNARIANPGQTRLVERAVEAAGGVVVQSWPEIGVVVAHSDRAAFRV
                     NVTAKGGNAVASVGATRTAGVSEGTPADLAAPWGPGANGYKKGAKKPDNGDIPSDPQPG
                     ESLDPNEGVQWDMQMIKAPQAQAISDGNRNVLVGVLDSGISPTHPDLKANIDVANSVNC
                     SNVGRPDQTPLAWRPTTSDHGTHVAGTIAAARNNIGIVGVAPNVRMASVKVVNDDGFIY
                     PEYAVCGFMWAGLKHMDVTNNSYYVDPFEFWCDDQPDQAASKEAVRRAVRWATEQGVVN
                     VAAAGNSNYDMANKTVDKGSPNDAPKPTVRTINSGCNDIPAELDGVVTVASLQRVGTTL
                     DSVRSSFSNYGLGKIDVAAPGSSIYSTTWNTRTGVDGYGTKSGTSMASPHVAGVMAQMK
                     SAHPSWSPAEMINELKARAVPKPCPQNTAACTGTVDDNSFFGAGVVDTLAVVK"
     gene            complement(17088..18020)
                     /locus_tag="HHX41_RS06325"
     CDS             complement(17088..18020)
                     /EC_number="2.7.7.41"
                     /GO_function="GO:0004605 - phosphatidate
                     cytidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016024 - CDP-diacylglycerol biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013327.5"
                     /locus_tag="HHX41_RS06325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="WP_169985491.1"
                     /transl_table=11
                     /translation="MPHVFWMTIAGMVTVLTAATTVGTVLARRAGPGNTTVLNLNQRIN
                     AWWVMIAVAGTAIVAGSHATIVLFALCSFFALREFVTLTPTKDGDYWSLLLAFYVALPV
                     QFALLGFRWYGLFSIFIPVYVFFVVSAAAALSQDTSDFLERNAKIQWALMVCVYGLSHA
                     PALLMLEIPGYYSGNGPLLLFFLLVVQSSDVFQYVCGKLWGRTPLSPKVSPSKTVEGLV
                     GGGLAAVLLGVLLHGLTPFTPWQAALMSLAIVAAGVIGGLVLSAVKRSLGAKDWGEMLA
                     GHGGMLDRVDSLCFAAPLFFHLTRYFFVP"
     gene            complement(18022..18630)
                     /locus_tag="HHX41_RS06330"
     CDS             complement(18022..18630)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013702.5"
                     /locus_tag="HHX41_RS06330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="WP_169985493.1"
                     /transl_table=11
                     /translation="MSSLLRVALVWLVRIVVGAHPRYLSALATGRQRIYFSNHTSHVDT
                     MAILAALPARLRESVRPVAARDYWDSSPLRSFVARRVLDVVFVERQRQGTGDPLDPLRE
                     ALREGASLVIFPEGTRGAGPEPGPFRSGIFRLSREFPDVELVPVSLSNLNRVMPKGKVI
                     PVPLLCRVGFGAPLERVPGEEKDAFLERARGAVITIGKT"
     gene            complement(18623..19180)
                     /locus_tag="HHX41_RS06335"
     CDS             complement(18623..19180)
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013250.5"
                     /locus_tag="HHX41_RS06335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_220503757.1"
                     /transl_table=11
                     /translation="MSGTSVTPNQISCASVVFAGLAGWVLSGAPGWAGCLAATVLIQLR
                     LLCNVLDGLVAVEGGKKSPTGALYNEFPDRVADSLVIIGAGYGAGLPEVGWLAALLAVT
                     TAYVRVFGGALGFEQEFLGPMAKQHRMAVLSAGCLMGAVESLLTATQYSLKAATVVVAV
                     GSAVTCWTRGRAIARRLRAADV"
     gene            19445..20005
                     /locus_tag="HHX41_RS06340"
     CDS             19445..20005
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024092.5"
                     /locus_tag="HHX41_RS06340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_182905153.1"
                     /sec_met_domain="PF07366 (E-value: 2.2e-07, bitscore: 26.3,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAASRIHLDSTLVDREFSIGLRLLSDIRGDEGDSVLATPRQLLDC
                     FHQAMLDFSPDSLADLFADEATYEFVFWTPHRGPSQRYDGREEIRAGFRAAWGSVSEPP
                     LTGFREMCVHETSDADVVISEGEMDGVNPATGQPFSSRFVLVLRARDGRIVHLRDYSDV
                     LRTAAGLGRLNQLFEQVRAESAP"
     gene            complement(20037..20738)
                     /locus_tag="HHX41_RS06345"
     CDS             complement(20037..20738)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024242.5"
                     /locus_tag="HHX41_RS06345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_182905356.1"
                     /transl_table=11
                     /translation="MGLDIESRSSDSPYIERVWRSSSRDVEQMTAVATAHWDLVFWEHR
                     GQVSASVQGPESKASSAPVPEEAAFFGISFSLGTSMPHLPVSRLVDGSAEIPDVTRGSF
                     WLKGSTWHLPDYDNAEAFVERLVREGVVERDPLVAAVLGGASPDVSERTVQRRFVTATG
                     LTRGTVRQIDRARRAAVLIQEGVPVHDVIHRLGYFDQPHLARSLSRYIGRTATQLSERN
                     PAQPLSLLYTP"
     gene            complement(20755..21093)
                     /locus_tag="HHX41_RS06350"
     CDS             complement(20755..21093)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HHX41_RS06350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_182905154.1"
                     /transl_table=11
                     /translation="MSTAVLPWGCATDCAYPTPKDVRRVVDYALTHGWDPDLAGGTFFL
                     SESEHAGEFGLDDFLLTDRLRDDGAPDPTEQVFRARGDRETGEVAPLPGSGKMIWAGLP
                     RGSARTGD"
     gene            complement(21425..21883)
                     /locus_tag="HHX41_RS06355"
     CDS             complement(21425..21883)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017568907.1"
                     /locus_tag="HHX41_RS06355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_182905155.1"
                     /transl_table=11
                     /translation="MDELDKAILAELQSDARKTNRDVAAAVGVSPTTALDRTRALRQRG
                     VIRGAILDVDLAAIGRPVQALIAIRVRPPSRRNIEGFRNWVSALPDTLGVYVTTGTEDF
                     IVHVAVPDNASLYAFVIDKLTERPEVADVRTSIVYEHLRNTRIGPSGP"
     misc_feature    21869..21883
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            21994..22479
                     /locus_tag="HHX41_RS06360"
     CDS             21994..22479
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017592434.1"
                     /locus_tag="HHX41_RS06360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2000 domain-containing protein"
                     /protein_id="WP_182905156.1"
                     /transl_table=11
                     /translation="MTADEGATTGVGFAPEEIDPALPTRAARLKWVIVVDGDLPAGRAV
                     NAAVCVAAATSTAVTGLLGDDAVDADGGAHPGLPWAGCSVLAADTATLRAIRTKAAASA
                     GCFVADMPAAAQRTRVYADYLATMKETAAGDVEYYAVSVVGPRNRVDKIVGKLPLMP"
     gene            complement(22499..22894)
                     /locus_tag="HHX41_RS06365"
     CDS             complement(22499..22894)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887090.1"
                     /locus_tag="HHX41_RS06365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ACT domain-containing protein"
                     /protein_id="WP_182905157.1"
                     /transl_table=11
                     /translation="MTSPAAQRLGIVPSVFAVQHLPQATFPEDDDWIALVRAPEGLTVI
                     REAWPTGSGDRWIGLYGGETGHHLDVPGMLAAIVGPLADAAVPVFVASTFHADLVLVPE
                     PRIKEAVAVLEDAGHRVDTRHLRSPGS"
     misc_feature    complement(22937..22952)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
ORIGIN
        1 gcagggaggc aagccatcag ccagggatct gcttttccct acggatcaga aggttaggga
       61 ttcgagtcct ctcggccgcg ccacacggaa gcccggatca tcagccgatg acctgggctt
      121 ttctgcgttt ggatcagttg agagtgtccg gctgtgtccg gccgtcagcc gttgtctacg
      181 ggtgatcctt cccaatacct tcccgcggca agggcccctg acctcgccgg ttcgcggcga
      241 cggagtcgag catgccgaag gtagccatcg tgagcgcgta cgcgatgccg gcgcgatgct
      301 tggtggatgc ggatgtgcgg tttggagggg gtgagccgta ccagccgtac cagcctcgtt
      361 tttgctggtg ttgatgctgg tacggctggt acggcttccc ctcccaatcg ggaccacggc
      421 ggcctcgggg aggggttcgg cggtggggca gtagcgttcc caggcgttgg cgaaattgcc
      481 gcggtggtag cccttggcct gcccgcttgc gaatcggatc gtggccggac ggatgtcgta
      541 ctcacgtcgg atcgtgccga gcttcatggg ggtcagaccg gtgggtccga agtcggccca
      601 gccgctttcg gggtcggcct tgagccgttc gagcagtacg gcggcgggta gggcggtgtc
      661 agcgccgaag gcggtacggc agtcggccaa caggcggata cgggtggagg tctgtccgtt
      721 gtcgtcggcc tcggcggtca gagccagggc ggcggcgcgg gcacggtcgc tccagtgggc
      781 gccagcgtgg tcagcggcga tgaccagggg ttcccaggtg tcggcggcgc ggtcttccag
      841 cggcatcggg ggttcggctt tgctgctctc accggagatc acccgccgcc tgatcgaccg
      901 ctacaccgcg atggctccgc cggtcaacgc ccccggcctg gctcacctga ccggcaggga
      961 ggccgaggtg ctgcgattga tggctcgggg gctgtccaac cgcgagatcg ccggggaact
     1021 ctttctcggc gaggcgaccg tgaagacgca cgtcaaccgc atcctggcca agctcggtgt
     1081 gcgggatcgc gtgcaggcgg tggtgctcgc ctacgaggcc ggcgtggtgc gggcctcgac
     1141 gcgaggcccg cacataagga tcctgctgac gacggccctg gacgaccatc gctgaggccg
     1201 gaccccgatc cggtgaagta ctggtgacag gccgtcgtcc cagtctcgtc aactccggcc
     1261 aggcgtgacg ttcagtggcc ggtgtgctcg tgatggccgt gggcatggcg taccttggcc
     1321 attgcgcggg cgatcaccgc caactcgtcg gggtccagaa cgtcgatcag gttctggcgt
     1381 acgaccttga cgtggccggg tgccgtgctc ttcaggcagg ccatgccctt gtcggtgagt
     1441 gcggcgagga tgcccctgtc gtcagagtcg cagcgtctgc gctcgacgag cccgcgcttc
     1501 tccagccgac cgatctgata ggtcagtccg ctcttggtga tgacgacccg gcgggccagt
     1561 tcggacatgc gaagctgcca gtcgggggcg tcggcgaggt ggacgaggat ctcgtactgc
     1621 ggatgggtga ggtcggaggc ctctttgagc tgttcttcga tgagtcgttc gagcaggtgg
     1681 ctggctgaga cgaactcgag ccaggccgcc atctcgctct cgttcagcca tcgcacgtcc
     1741 gtcatctccc caggatatgt tcaaaactga acgaccaggc tagtctggcc tgtgtcgttc
     1801 aagtttgaat gaatcggggt ttcatgatcc acaagtttcg gccggttgcg ctgctgctcg
     1861 cccgggtcgc cgtgggcgtc atcttcatcg catacggctg gcagaagctc ttcgtcaacg
     1921 gcgtcgccgg gacgacccag ttcttcgagt cgatcggtgc gcccatcccc gccgtgacgg
     1981 ctccgctcgt tgggctactg gaggcggtcg ggggagcggc cctggtgctt ggggcgctgt
     2041 tgccggtggc aggcacgctg ctggcgctca acatgatcgg agcgatcatc ctggttcacg
     2101 gggccaacgg cctgtacgtg gacaagggcg gctacgagtt cgtcctggcg ctcgccgcgg
     2161 cggccctggc catcggcttc acgggcggcg gcatgctggc cgtcgacgac ctgtggaagc
     2221 gccgtggttc ggagaagctc gccgccacgg ctcactgaga gcggcacgcc cctctcgccg
     2281 gtttcggcga gaggggcttt ttcgatctat ccctgatctg gtgtcccttc atctgggcgc
     2341 catctggacg cctggcacgc gggaaggacg ccgctgcggg ttaacgccgc agtcgcagcc
     2401 ggcggaggcc gaaaacgatc gacgcgagca gcggccacag catccaggtg tagagaccgg
     2461 cgagccatgc ggtgtcgaag aacgccgatg cacgagcagc ccgatcacgc tgctcaggcc
     2521 gatcgcgcgc ttcggtcggc ccagtagagc gctcgcaatg gcctccgtcg ccgctcgctt
     2581 atcgccctcc acgaggtgcg gtggttgtca ggcggcgcgt aagcctgtac ggggagcctg
     2641 tcgggacagg ctgacaacac gatctccttg tggacggcgt gagcgatccg aaaccgtgga
     2701 tccgctgcag gaatcacctg ccggcgttcg acaccaggag aaacgatgaa gctgcctgca
     2761 tgcgccgccg ccctcggggc ggccgccctg ctcgcttgct tgaccggagc gttcgggatg
     2821 tcggcggcac aggcagccga cgccagggcc cttccgagcg tgaacatgga agccactgtc
     2881 aaggcggccc agatcgaccc gcggcggtct gacgacacgc tgaccccggg cgccaaggcc
     2941 agcgtgctcc tcgtcgagcg ggcgttgcgt gaccggcacc tgctcgacgc gaagtgggtg
     3001 gacggttact tcggcaccac gacggtcgtc gccttcgcga agttccagag gtcgctcggc
     3061 ctcactggtc tcgccgccaa cggccttccg ggcagggcgt cgctcaccag gctcggagcc
     3121 ggccgtttca cggtcaccca cattatcggg gcgggtgcac gggtatccgc cggcggcgtc
     3181 gtcatcgaca cccgcacgcg gagcatgctg gtcgaggcga agcggctgct cggccgcgac
     3241 ctcgtgctgc tgcaggggtc gtacaaccgc ggcggcgacc ccacgtccgc gggcacccac
     3301 gacggcggcg gcgtcgtcga catctcggtc aaggggatga attccgtcac ccggatcgcc
     3361 gttgtccgtg cgttgcgacg tgtcggcttc gcggcatggc tgcgtagccc cgatcaagcc
     3421 gactggccat ggcacatcca tgccgccgcc atcaacgaca ccgacctctc cagccaggcc
     3481 cagcatcaga tcggtgacta ctacctcggt ctgaacgggc tcgccggccg tggcccggac
     3541 gacggcccga aggtgaccac ccgcacctgg gaggagtacc agcgccgctg agcatccgac
     3601 acccaggctg cacagacacg aaggagaaca ccatgggaac gcttgacaag atcctcgcca
     3661 cggcggccgc cgcgatggtg ctcggcgggg cggtgctcgc caccgcctcg cccgcctcgg
     3721 cggccacccg caacggcgtg tgcgagaccg gcgagttctg ttactacttc aacagcaaca
     3781 accaggggtc gctctccgac ttcaccggat ccgtcggcgg ctacggcacc gagcagccat
     3841 cctgcttcga cttcaaggga cccggcaccg gcaagggcaa gtgcgtcaag aacgccgccg
     3901 cctcggtctg gaaccgcagt ggtaagaccg tccgggtcta cttcaacagc aactacggcg
     3961 gcagcgtcta ccaggacttc gcgcccggcg ccaagggcaa cctcaagccc ggcctcaaga
     4021 accagaacgc ctcccaccag ttcggcccgt cgtcatcggc gcgcgtcaac atgtcgtacg
     4081 cgctgtacca gaccggcggc ggctacatca gctgcggttt cgacggttac gtccacacct
     4141 ctggccggca cgagggtatc gacatcaagc gcagcgaggg ttcggatgtc cacgccctgg
     4201 tcagcggtca gatcatcaac gtcgtgcacg ggcgcaacgg cggctccggg ctctccacga
     4261 tcgccatcta caacgcctcg ctgaacaaga cgatcatcta cctgcactcc gctccgctgt
     4321 cctcgctgcg tgtgggccag cagatcgcgc gcggccagat catcgcggac gaggcgtggc
     4381 acggcgtgtc gtcccgcagc gccgcgcaca cccacgtcga gatgcgtcct ggacggcaga
     4441 agctcgccgc caagagcgtc cgcgacccga atctgagcaa cccgaacccg aactcgttct
     4501 ggaactccca gggctacaac gtccgctagc gcaccgcggc ccccaagaag aggaaggcga
     4561 ctgtgtctcc acgaactgca cggctgatct cgcggcccgc cgcggcggcc gccgcgctgg
     4621 tggtcggcgc ggcggtgctc gccaccgctt cgcccgcctc ggcggccacc cgcaacggcg
     4681 tgtgtgagac cggcgagttc tgttactact tcaacagcaa caaccaggga tcggtctcgg
     4741 acttcaccgg atcggtcggc gactacggca cccggcagcc ctcctgttac gacttcaagg
     4801 gaccgggcac cggcaagggc aagtgcgtca agaacgccgc ggcctcggtc tggaaccgta
     4861 gcggcaagac cgtccgggtc tacttcaaca gcaactacgg cggcagcgtc taccaggact
     4921 tcgcgcccgg cgccaagggc aatctcaagc ccggcctcaa gaaccagaac gcctcccacc
     4981 ggttcctgag ctccgcgccg ccgaccgggt gcaagaccga cggcacggac agcaggctgc
     5041 ccacgacgat cctcgtctac cgggaatccc tcaaccgcgt ggaccgggtg gagttcaaga
     5101 cctacatcaa gaacgtcctg ccgaacgagt ggcggtcgca ctggccgagg gagtctctcc
     5161 gggccggggc gatcgcggtc aagaacttcg gctggtactg ggcgctgagg tcggcgagca
     5221 agacgcccag cggccagtgc tacgacgtca ccgaccacac gtccagccag atgtacaagc
     5281 cgggttcggc gacggcggcg acgaacgccg cggtggacgc gacctggggc atccggatga
     5341 cgcgcaacgg gaagatcttc aaggcgcagt actgctccac gacgacggcc tgccgccact
     5401 gggtgaccgg cgactggatg tcgcagaacg gctctcgcga caaggccgag gcgggctgga
     5461 gctactccag gatcctcagg tactactaca aggggatcgc tctcacgtcc tgagcagcgg
     5521 gaggcggtcc gcccctgttc cccgccgtgt cgtgcacggc ggggaacagt cgtcagccga
     5581 cgatgacctg gaagttgagt ggccggcctc cggggaacgc gacccgtccc gagccctcca
     5641 tcatcttgaa ccgcacatag cacaggcctg gcttcgtcgg cgtggtgatg tcggtccgga
     5701 tgtcgaccat ctctccgggg cgcgtgtcct ttatcggtat gtcggggacg gtctggcatt
     5761 gatcgggttg ctgcgggagg tcgatgcgat gcagcgaata tcccttccac ggcacggtcc
     5821 cagcgttctt gagccgccat accttggtca cggtctgacg ggggccgacg cgcgtgcagt
     5881 cgggcagcgt gatgtctccg atgaacttcg ccgaatcacc ctcgtgcaca ggcgggctcc
     5941 acggcgggtt ggtggcgcgc accgggcagt cggctgccga cagcccggtc ttcgatgcgc
     6001 tctcggacgg gttcacgttg tgcccgtcgg tcccggagcc acgattgacg gcgaccgcga
     6061 tgagaaccac tgccgccaca ccggcggccg ctaccgcgag cgcggccgcg gccgggcggg
     6121 ttggccggaa tcgccctcgg ccccccggca cggaggggac tggctggacg tcgcccgcaa
     6181 tctcatgggg cggcggcgta ggcggagatg ccggggccac accagccggc cgcggggctt
     6241 gcggcccggt ggcgccgggc acggcacgat cttccgcgat gtccgtggcg gaggcttcga
     6301 gtccatcagg cggaccggcc cgcaaggtgc ccgcgcggct tgaaggatct ccggcgctcg
     6361 ccgatctgac cgctaaattc gccctctccc agcgttcacg gtacgcggcc gagtctgcgc
     6421 cgcacgcctt gacgaactcg acggtggtct cccaactcgg gagccggtta cccttcgtgg
     6481 cttcgtgcag cgtcgtgtgg gagatcgccc ccgaccggcc agacatttct cggaaaggtg
     6541 ggttgccgac cgatttgcga agttctcgca gtgccgccgc gaagtcctcg atcgcctccg
     6601 cccgtgcggg catgtcgtcc accgggtgaa gctaacagcg cccacggtat ccactcaagc
     6661 ttacggagca tctcgcatac gtcctcctgc gcctcgctcg ccgcggcagg gttgggagtg
     6721 gcctgcaccc agatcgtctc cgtcgacgta gcttcggcca gctccacgcc cggctggatc
     6781 agctcgaaga agatcgccag acagccgcac gtccaggccg gaacgagctc tcggctggtg
     6841 ggcgtgggat cgagccggtt ccgcagagtg cgtggtcgat cagcgtggag gccgctccaa
     6901 tttgacgcag ggagcggtcc tcggagttcg cgttctcggt ggacaccgag acgacgacgc
     6961 cccgccggcc gtcctcggtg aagccgttcc tcgtcatgaa tccgacgatg tctccgccat
     7021 ggccccagta gtttccgccg cacgacagcg ggatggagaa caacccgagg ccgtaccgcg
     7081 ctccgggaaa ggcttgtcgc acctccgcgt cggtggcgac ggtccgtttc atctggtcga
     7141 gttccgccgg gcgcagcagc ctgccgctga ggagagcgcg atagaaccgg tcgaggtcgg
     7201 cggtggtcga gatgatggct ccggcggcgt cggcggtgta gggcgcacgg gttcgggtga
     7261 cgtcgatgag cgtgccgtca gggtaccggt cgtaaccctc ggaatgcggg tccggaacgt
     7321 ccggggagag gcccggcaca ctggtgttcc gcagaccgag cggacgaagg atgcgccggt
     7381 cgacctcctc ggaccacggg cggccggtca cccgtttgat gatcatcccg agcaggacgt
     7441 acccggcgtt gcagtacctc catgacatcc cgggcgcgaa gtcgggccgg tgccgcatgg
     7501 cctctttcac caacgcgtcc ggcgggacga tgtcgaaccg gtgccggtag tagtcggccg
     7561 gtgtctcctg tccttcgtcg ccttcatgga taccactcgt gtgctggagc agctgacgaa
     7621 cagtgatctt gctgccgtcg ttgccgttgc cgtgcaccac gccgggcagc cgacgttcga
     7681 ccgtgtcgtc caacgacagc ttcccttccc ccgccaactg caggacgacc gtcgcaacga
     7741 acgtcttggt ggagctgccg atccggaaat gatcgtccgg cttgaccggg cgcctggtgc
     7801 cggtgtcgcc gaaaccactg gtggccacca ggttgtggct gtcacgggtc gcacgcgcct
     7861 ggacccctgt cgccccggtc gcggtgatcg catcggcgtc gcgctgcaac cggctctggt
     7921 cgtacggctg tggcgcggcc gtacgcgtcg cggccggccc gcatgccgct gccccgagca
     7981 cactcgccag gatcattacc gacgccacaa ggcgcgcccg gggcccacgc ggcttcggcg
     8041 ctctcacgta ccgtgatgtc cccctgaccg tgggatccat gtgtgaccga tcagccgagc
     8101 cgggagaaac gccgggcggc cacgaccagt gtgatcacgg tgagagcggc gacgacggcc
     8161 atttcggcag gcggcgacag acgcaggtcg ccccagctga gcggctggga cagcatcgcc
     8221 cgtccgcgcg ggaaccgaac gattccggtg gtgtggcgca tggcgtccac ggcataggtc
     8281 agcgggtcga ggcgggacag ccacgccagc cagcccggca gcgcgctgat cgggaacatc
     8341 gtcccggaca ggaacatcag gggggccatc aggacactga gcacagtggt cagcgtgcgg
     8401 ggtcgccgga cgaaaaccgc gaccgccgcg gccaggaccg tcagcgcgaa cgacgtcagc
     8461 gccagttcgg cggcgagcat cgcgaacgcc gcgggccggt acgggacgtg gagcagcccg
     8521 gcactggcca ggatcaccat gccgtggcag gtcgcgaccg tcatgccgcc gaggcatttg
     8581 ccgatcagca gggtgctccg cgacacgggg gcgacgagca tctcacggag gaaaccgtcc
     8641 tcccgctccc agacgatcga cgcgcccacg gacatcgcgg cgggttgcgc ggccatcacc
     8701 agcacaccgg ggaagaagaa cgtcagatag tccgacgcgg accccgcgcc ggaggcggcg
     8761 aagagccctc ccagaccgat gccgaggatg aagaggaaca tcagggactc caccagggac
     8821 accagcgtgc cgacccgatc gcggaggaag tgcagcatct cccgccgcca caccatgcgc
     8881 gcggcgacga gttcggcggc gaggccgcgg ccgtacgcgg cgcgtggcac agtgccgccg
     8941 gccatcagcg gcctcccccg ggctcgtccc ggatgtggtg cccggtgtga tggaggaaga
     9001 cgtcgtcgag gctgggcctc gtgactgtca gctcgtggac cgggacgtcc aggcccgcgc
     9061 acagccgggg tacgaggcgg gctccgttct ccgcctggac gcgcaggcct cgcggtccgg
     9121 cgacggcctc gatcccgaag cgttcgcgca gcgtcgcggc cgccgccacg tcgtcaccgg
     9181 tgcgcaggtc gatgcggtcg gcggcgagcg tcgacttcaa ctcggcgggc gtgccctggg
     9241 cgacgatccg tccgtcgtcg acgatggcga tgcggtcgca ccgctcggcc tcgtcgaggt
     9301 agtgcgtcgt gaggaagatc gtgatcgtct cacgttcacg cacctcgcac aggtgtgccc
     9361 agagccggtc gcgtgcctgc gggtccaaac cgatggtggg ttcgtccagg aacagcaccc
     9421 gtggccggtg cagcaggcca cgggcgatct ccagacggcg gcgcatcccg ccggagaagg
     9481 tccgtacgag gtggtcacgc cgtgccgtga gcccggccag gtcgagcatc gcgtcgatcc
     9541 gggcggccag cccggccttg ggcatggcat acaggtcggc gtggaagcgg aggttctctg
     9601 cggcggtgag ctccccgtcg agcgtgctct cctggaagac gattccgaga cttcgccgca
     9661 ccgggccggg cgcggtccgg gtgtcgtgac cggccacctc gatgcggccc gcggtgggca
     9721 cggcaagtgt gcacagcatc gcgatgatcg tgctcttgcc cgcgccgttc gggccgagga
     9781 ggccgaacgt ctcgccctgc tcgaccgtga ggtcgacgcc acgcacggcg tccacgtccg
     9841 gataggactt gtggaggccg gtcgcccgta tcgcgggaac gccctggcac cggcgtgcgg
     9901 tgggcggcgc ctgggcgctc cgatggccgg ttccgaacac ggttcctccc tcaggccttc
     9961 ctccgcatgc ggcgcgatga cggcgtcgtg cccacttctt tcatccgccg ggtactggat
    10021 cgaggagcag gggggacggg acccggtcgg ggtgggccag gcgcaggaag tgcatgccga
    10081 ggccggatct cccgatcatg agtccgggga agaaacccgc tgtgtcctgg atgagaccgt
    10141 tctgggtgtc atcgaagtgc cgccattgct cgtgcgcctg gacgttcgcc tccaaccgga
    10201 aggtcggctc gtcgtgcagc ctggcgaaac gcaggaacag ttcggcgttc cccgaccggc
    10261 cgtggcagag cgtgtcgttc cgcagccggg ggaagttccg tagcgtcgcc gtgagggcgt
    10321 ggtgcgtgtc ccgcagcagc gactcgtcgt cgccgtcgag gagcgcccag ctcgcgatgc
    10381 ggctcaggcc gatgccggcg gcgccgttgc accaggcgtt ggcgtagtag cggccgtcct
    10441 gcagtacgcc gccggggctg gtgcgcaggt cgtaccagtc gttcgtggtc tcgtcgaagt
    10501 gccgggcctc ataggccagg gcacggcgtc cggcgatcac gtactccgtc cggtccgtca
    10561 gccgcccgag ccggatcagc gcccatccga taccggccgc tccgtgggcg aagcccgtca
    10621 gattggccgg ggcgatgcga ggatcgggcg gcggccagct cagcgtgccg gcgtccgcga
    10681 cggcgcggcg cagcaacact ctcgcgcaca gatgcgcctg gtcgacgccc tcgccgtccg
    10741 cctcggaggc gagcccgagc agcaccggga tgaggccggc ggcaccgctg aagacgtcca
    10801 gtgccgtgtc ggcctcgatc cgggatcgga ggtcctcgct caggcgcacg gcgagcccga
    10861 gcagttcgcg gtcccgccag aggcggtgca ggtgagtgag caggtagatc aggccgccga
    10921 cgcctgtgaa agcgccgatc tgccggcgat cggtggccgc gacggcgtgg gacagggccc
    10981 gttcggccgc ccgccggaac tccggtcgcg gaacgatctg gtcgaggtag gcgaggaaca
    11041 gtgcgatgcc cgccgccccg tcgtacaggt cgccgccgat gtcgacccgt acgggcccgt
    11101 ccgggctgat ctcgtacgac gtccacggtg cgggctccga cggctcgcgg agcatggcgc
    11161 acaggcgctc gccgacccgg ctcgcctgtt cggcggcggc ggacacgaag gccgggctgg
    11221 cgacctcact cgtgcgcagg ccggccgcga tgtagcggcg ttgccgctcg cggttgtcca
    11281 cggacagcga ccggatccgc tgcgcggcgc agccgagcgg agaggtgtcg aggtcgatcg
    11341 ccagcggcgt cgtgtggtcg tggatgagcg gcccgccgcg ggcgtccatg gtgaagatcg
    11401 gtatgtcgag ccgccacatc gactcgacct cccgctccgc gagccggccg tcccggtccc
    11461 agctctgcag gaaggtacga accgtgccga gggtcaggtc gacctccagg gggtcgacca
    11521 ggcacctggg gtgccgggcg tgctgcaaca ggttgacgta gagctgggtg gcccagttga
    11581 cgaaccggac ggagacgccg ccgaacatct ccgtcaccgc gcgtaccgcc gcgtcaggcc
    11641 ggcgctcgaa ccattcgtgc acccggccga acccctccat gatcgcttcg gtgaagtcct
    11701 ccggtcgtac gaccgtgtcg ccgaccaaca cccggttatg agtccccggc tcgacgcgca
    11761 cgccggtcat gtgcgtcacc gacgtccgga agctgtcgcg ccgctcttcg aggcagggca
    11821 cgggcatcgg gagctcgtac gcctcgcctc cggagtagcc gctggcccgc atcaggtcac
    11881 cggagcccgc cgcgcgcggc cactcgagca gtccggttct gaacaccgag tccaggaggg
    11941 tgcccggcgg tcgtgcctga ccacgtaaga gcacgctgag ggcggtctcg caatcgcaga
    12001 cgtgggcgtg accgtcggcg accagaacat tctccaaatg caggtcgtct ccgcccagta
    12061 cgtagaagat ccccaggtga ccgccgagtt cccggtaaag ccgctcgacc tcctcacggg
    12121 tcgtcacatg gttacggccc ggggggatcc gctcctcata gccgtacccc ggccgtggca
    12181 ggacggcata cggcgcgaaa tcgagcactc cgtcgtcgcg tagccgcgcg agcagtttct
    12241 gcatcgtcgc ctcggcggcg atcgagcgcg gcttgtagac gaacgaaccg gtcgccccgc
    12301 tcaccagccg agcctcgaca agggcgacgg tgcgggctcc ggcgtggtga tcggagatcc
    12361 ccggccgcag tgacaggaac gatgagatgt cctccccgaa gatcgtctgg ccgatcgccg
    12421 cggcatccgc ctcgaggcgc tcgacgagct cgcatccgaa gtccgccagc aaggcggtga
    12481 tgtgcgccag ccagcgtccc aggaccggga acccgagatg gaagcggtgg tggtcggccg
    12541 cctcggcgaa tgtggcgtcg aggtacgccc ggaagtcctc acgggtcgcc cgtgccctgt
    12601 cgatgcccgc ctcggcgcag tgaaccttcg cgtcggcctc cacggcccac gcgagtgaca
    12661 gctcgaaacg ctcgaaaaga tgccgctgca gatcgtcggt catgcgacgg ctgaatcggc
    12721 ccggatggca ggcccgggcg gcgtccatcc ggcggccgag ttcgaggagg aacggctcgc
    12781 aggcgatggc gagccgaccg tagtagatct cggggcgccg ccaactcgcg tcctgcgcat
    12841 cctgggcgga gcggtcgaac ccgccgagtg cggcctggta ggtcggcagc caggagcgct
    12901 gcacctcggc gaacaccgcc ttggtgtcgt cgtcggcatc gcgcaggccg agctcgtgat
    12961 gccggaaggc ggtaagcgcc cgccggaggt cgtcccgccc gggggccgcc ggcgcggacg
    13021 ggtccggtgc cctgacgtcc gtcttcacgg ccagccgctg ggagatccgg tcgatcttcc
    13081 aggcgtcgaa tcggggaagc gggtcagcga acgtcgccgg tccggtggcc tccagtccgg
    13141 ccaggattcg cagacgttcg gcgaggttcg cggcagcggc ggcgatgtcg acaaaggagt
    13201 ggtggtcgcc caacggtcgg actccttttg gtacgcgacg gacggctggc cggccgtggc
    13261 cggttaactg tgcgacttgc cgtgttttcc cgttcgcacc tagtgcgaca tgacgcgaat
    13321 atgaaggcca tgccgtaggg gcaggcgttt gttcttgatg aacagatctc ggtccgcgac
    13381 ggccacctac atcccgtgtt cattcggcat gggatggctg ccggtcggcg gcggcgcgga
    13441 cgacggtggc cggccgcgcc gatgtcggcg tcctcttgcc cggcgcctaa taggtcttac
    13501 gacagacgtg ggtgtggatg caatgatggg tggccggaca ggcgtagatt tcgctggcgg
    13561 cgcccgtcgt ccaggatctc agcgactcct ggtcgggctg ctcgatcggg tcgggtaacg
    13621 cggaaacctc agtatcgaag gcgattggat ccgtcatgag ttcggcgcgg aactcatcgt
    13681 cgacggtggc ctgaagtgcc atcatcctgt ccattgcatc tccttgatcg agcttcggag
    13741 aaatgatcgt ccgggctggg tcgaatattc gcatccggct tgccctctcg tattttcagt
    13801 atcacctccg gtgctacatg tgttgcaacc gggacgtaaa cttgtcggca agatggcggc
    13861 agtgttcagc tctttgttcc gaggccttta actttgttta cgcgtttctt gtttgattgg
    13921 caatcgtggc ggtattgaat ggtcgcgtgc aggtgccagg ggaggtccgc tccgcggtga
    13981 cgggcggata agccgggccg gcacggggtc agggagggcg gatgaagcgc acaccgcttc
    14041 gcgcgcaggc ctctcgccgg gcggtcatgg cggtggcaac cctcgccgtg gcgcttctcg
    14101 gccccccggc gtctcccctc ccggttccgg acaaggacgg agactccgcc ctgcgcgcgg
    14161 tgctggccga ggcggtgcgc cagaaccact atccgggggc gttggcgcag gcatggagtc
    14221 gggagcggac ctccgacgtg gcgatcgggg tcggcgacgt ccggaacggc acggcgccgc
    14281 ggcctgatgc gcgattcagg gccgggagca tcacgaagac cttcgtcgcc accgcggtcc
    14341 tgcaactggt cgccgaggat cggctccgac tggacgacac cgtcgagcac tggttgccgg
    14401 gcctggtcga cggcaagggc aacgacggcc ggcggatcac cctgcggatg ctgctgaacc
    14461 acacgagcgg ccttttcgac tacaccaccg acaaggaact gggccaggcc tatgagcgtg
    14521 acccgtcccg ccgtcttgtg ccgcgcgcgt tggtccgcgt cgcggtctca catcccccgc
    14581 tgttcccgcc cggggcggcc tggaactact ccgacaccga ctacgtcctg ctcgggatgg
    14641 tcattcagcg ggtcaccggc cggccgtaca cggaagagat cacgcggcgg atcatccggc
    14701 ctctgggcct gcgctcgacc tacttccccg gcggatcctc gtccatcgcc cctccctacc
    14761 tgcacggcta cacgatgtcg gactccggtg ccgtcaagga cgcgaccgtg ctcaacacga
    14821 gcttcgcgcc cggatccggc gacctgatct cgaccgtcgg agatctgaac cgtttcgcct
    14881 cggccctgct ggcggggcgt ctgctgccac agcctgtcct gcgtcagatg ctgacaccgg
    14941 ttcccggatc ccgcgcgggc tcggatatcg acgaatacgg cctcggcgtg atcatcacga
    15001 agctcccctg tgggatcacc gtgtacggcc acggcggcac cctcgatggt tatctcaccg
    15061 gcgtgaccgg gcggtcgggc ggtacccaca cgctcgcctg ggtgatcaat ggcagttggg
    15121 gagtggagaa ccagatcgcg ctgatggaca aggcctacat cgccgagttc tgcggcagcc
    15181 gtcagccgcc gcgccgggtg tgggaatgac atgcctcgtc gccgtacggc actgggcccg
    15241 caccgtcgtg acgatgcggg cccagcgtgg tggtctcact caggtgacac cggggtcagt
    15301 tcacttgacg accgcgaggg tgtcgacgac accggcgccg aagaagctgt tgtcgtcgac
    15361 ggtgccggtg caggccgcgg tgttctgcgg gcacggcttg ggcacggccc gcgccttgag
    15421 ctcgttgatc atctcggccg gcgaccagga cgggtgcgcc gacttcatct gcgccatgac
    15481 gccggcgacg tgcgggctcg ccatcgacgt accgctcttg gtgccgtagc catccacccc
    15541 cgtccgggtg ttccacgtcg tcgagtagat cgacgagccg ggagccgcga cgtcgatctt
    15601 gccgaggccg tagttggaga aggacgaccg gacgctgtcc agcgtggtgc ccacgcgctg
    15661 cagggacgcg accgtcacga cgccgtcgag ctcggccggg atgtcgttgc agccgctgtt
    15721 gatcgtgcgc acggtcggct tcggcgcgtc gttggggctg cccttgtcca cggtcttgtt
    15781 ggccatgtcg tagttggagt tgcccgccgc ggcgacgttg acgacgccct gctcggtggc
    15841 ccaccgcacg gcgcgccgga cggcctcctt gctggcggcc tggtcgggct ggtcgtcaca
    15901 ccagaactcg aacgggtcga cgtagtagga gttgttcgtg acgtccatgt gcttcaggcc
    15961 cgcccacatg aagccgcaga cggcgtactc cgggtagatg aagccgtcgt cgttgacgac
    16021 cttgacggac gccatgcgca cgttcggcgc gacaccgacg atgccgatgt tgttgcgggc
    16081 ggcggcgatg gtgccggcga cgtgcgtacc gtggtcgctc gtcgtcggac gccaagccag
    16141 cggcgtctgg tccggacggc cgacgttgct gcagttgacc gagttcgcga cgtcgatgtt
    16201 ggccttgagg tccgggtgtg tcggcgagat gccgctgtcg agcaccccga cgaggacgtt
    16261 gcggttgccg tcggagatcg cctgcgcctg cggagccttg atcatctgca tgtcccactg
    16321 gaccccctcg ttggggtcga ggctctcgcc gggctgtggg tcggacggga tgtcgccgtt
    16381 gtccggcttc ttggcaccct tcttgtaccc gttggcgccg gggccccacg gcgcggccag
    16441 gtcggccggc gtcccctcgg agaccccggc cgtgcgggtg gcgccgacgg aggcgaccgc
    16501 gttgccaccc ttggcggtca cgttcacgcg gaaggccgca cggtcggagt gggcgacgac
    16561 cacgccgatc tcgggccagg actggacgac gacacctccg gcggcctcga cggcgcgctc
    16621 gacgagacga gtctggccgg ggttggcgat ccgggcgttg acgacgtagc tcatgagcat
    16681 cccgtcgggg atgtccacgt tgaccggtgt agacgtcggc tcgtcggtgg tggccgcgct
    16741 ggccgagccg gtcgcgcctc cgaggaaggc ggcacccacc atggcgaacg ccgcggcggt
    16801 ggccgcgagg cgtcgcttgg gcagggcatg ctgcatgggt tgctcctaga acggtgagac
    16861 cgcggcacca tcgccgtggt ctggctggct tcggcgccga aagtccgaaa tcgtcctgaa
    16921 accagctttt agagttggtt ggtgacggta acagctcgat cgtgaattgt tcaagagttc
    16981 accagagcgt aacggcacct gccgggcccg gcagcggccc atccgggcac gccgccgcac
    17041 agcggcacgt acggcgacgc cgtccggcgc gcgggggccg gcgcgggtca tgggacgaag
    17101 aagtaccggg tcaggtggaa gaacagcggt gcggcgaagc acagtgagtc cacccggtcg
    17161 agcattccgc cgtgcccggc cagcatctcg ccccagtcct tggcgccgag cgagcgcttc
    17221 accgccgaca gcacgaggcc gccgatcact ccggccgcca cgatcgcgag cgacatcagc
    17281 gcggcctgcc agggggtgaa cggcgtcagc ccgtgcagca ggacgccgag cagcaccgcc
    17341 gccagaccgc ccccgacgag cccttcgacg gtcttggacg ggctcacctt cggcgacagc
    17401 ggcgtgcggc cccagagctt gccgcacacg tactggaaga cgtcgctcga ctgcacgacc
    17461 agcaggaaga acagcagaag cgggccgttt ccggagtagt agccgggaat ctccagcatc
    17521 agcagcgcgg gggcgtggct caggccgtag acgcacacca tcagcgccca ctggatcttg
    17581 gcattgcgtt cgaggaagtc ggaggtgtcc tgcgacagcg cggcggcggc cgagacgacg
    17641 aagaacacgt agaccggaat gaaaatcgag aaaagcccgt accagcggaa cccgagcagc
    17701 gcgaactgga ccggaagcgc gacgtagaac gccagcagca gcgaccagta gtcgccgtcc
    17761 ttggtcgggg tcagcgtgac gaactcgcgg agcgcgaaga acgagcacag cgcgaacagc
    17821 acgatcgtcg cgtgactccc cgcgacgatc gcggtgccgg cgaccgcgat catgacccac
    17881 caggcgttga tccgctggtt gaggttcagc accgtcgtgt tccccgggcc ggcgcgacgc
    17941 gccaggaccg ttcccaccgt tgtcgccgcg gtgagcactg tcaccattcc ggcgatcgtc
    18001 atccagaaga cgtgcggcat gtcaggtttt tccgatcgtg atcaccgcgc cccgagcgcg
    18061 ttccaggaaa gcgtccttct cctcgccggg cacccgctcg agtggcgcgc cgaaccccac
    18121 ccggcacagg aggggaacgg ggatcacctt tcccttgggc atgacgcgat tgaggttgga
    18181 cagactcacg gggacgagct cgacgtcggg gaattcccgt gagagccgga atatgccgct
    18241 ccggaacggc ccgggctccg gccccgcgcc ccgggtcccc tcagggaaga tcaccagaga
    18301 ggccccctcc cgcagcgcct cccgcagcgg atcgagcggg tcacccgtcc cctgccgctg
    18361 tcgttcgacg aagacgacgt cgagcacgcg ccgcgcgacg aagcttctga gcggtgagga
    18421 gtcccagtag tcgcgcgccg ccaccggccg gacgctttcg cggagccgtg cgggaagcgc
    18481 ggcgaggatc gccatcgtgt cgacgtggct ggtgtggttc gagaaataga tccgctggcg
    18541 gccggtcgcc agggcggaca ggtatcgggg gtgggcgccg acgacgatcc ggaccagcca
    18601 gaccagcgcc accctgagga gactagacat cggcagcccg caatctcctg gcgatggcgc
    18661 gaccgcgggt ccagcacgtg acggccgagc cgacggccac gaccactgtc gccgccttga
    18721 gcgagtactg cgtcgcggtc aggagggact cgaccgcgcc catcaggcag ccggccgaca
    18781 ggacggccat ccggtgctgc ttcgccatcg ggccgaggaa ctcctgctcg aagccgagcg
    18841 cgcccccgaa cacccggaca tacgcggtgg tcacggcgag aagcgcggcg agccacccga
    18901 cctccggcag ccccgcgccg tatcccgccc cgatgatgac gagcgagtcg gcgacgcgat
    18961 ccgggaactc gttgtacagc gcgccggtcg gggacttctt ccctccttcg accgcgacga
    19021 ggccgtccag cacgttgcac agcagcctca actggatgag caccgtcgcg gcgaggcatc
    19081 cggcccatcc cggagccccc gacagcaccc atcccgccag acccgcgaac accacactgg
    19141 cgcaggagat ctggttcggc gtgacggagg tgccggacat ccatgaggcg acaccccgga
    19201 cagcgccatt ggaccgggat ctgacaggcc ggcgttgcag cgtcatatcc gtccttcgct
    19261 gattcgttcg gaaccggcga gcgcatcgcc ggacaactct ctcgtcactg ggccagccgt
    19321 atccgtgcac tgctggaggg cggctcatcg ccctgccgga caagacccgt gaactcggtg
    19381 atcattagta gttccgggcg cttgacgact gcttgaatcc cggttaccag cggtaaccga
    19441 aggaatggcg gcgtctcgga tccatctcga ctccacactt gttgaccgtg aattctccat
    19501 cggtctacgt ttgttgagcg acattcgcgg cgatgaaggg gacagcgtgc tcgcgactcc
    19561 acggcagctg ctcgactgtt tccatcaggc gatgctggac ttctcgcccg actcgcttgc
    19621 cgatctgttc gccgacgagg cgacctatga gttcgtgttc tggacgccgc atcgcggtcc
    19681 gtcgcagcgg tacgacgggc gcgaggagat ccgtgcaggc ttcagggcgg cctgggggtc
    19741 ggtgtccgag ccgccgctga ccggatttcg cgagatgtgc gttcacgaga cgtccgacgc
    19801 cgacgtggtc atctccgagg gcgagatgga cggcgtcaac ccggcgaccg ggcagccgtt
    19861 ctcttcccgg ttcgtgctcg tcctgcgagc ccgcgacggc cgtatcgtcc acctgcgcga
    19921 ctactccgac gtgctgcgga ccgcggcagg gctcgggcgt ctgaatcagc tcttcgagca
    19981 ggtgcgggcc gagtccgcgc cgtgaattcc ggtgctgtgg cccggcgggc gagcggtcag
    20041 ggcgtgtaga ggagtgacag cggctgcgcc ggattccgct cgctcaactg ggtggcggtg
    20101 cgcccgatgt atcggctcag ggaccgtgcc aggtgcggct ggtcgaagta gccgagacgg
    20161 tggatcacgt cgtggaccgg cacgccctcc tggatcagga ccgcggcccg ccgggcgcgg
    20221 tcgatctgcc gcacggtgcc gcgggtgagc ccggtcgccg tcacgaagcg ccgctgcacg
    20281 gtgcgttcgg acacgtccgg cgacgcgccg ccgagcaccg cggcgacgag cgggtcgcgc
    20341 tccacgacac cctcgcgcac cagccgctcg acgaaggcct cggcgttgtc gtagtcgggc
    20401 aggtgccacg tggaaccctt cagccagaag gacccgcgcg tcacatcggg gatctccgcc
    20461 gaaccgtcca cgagccggct gaccggaagg tggggcatcg acgtgccgag agagaagctg
    20521 atcccgaaga acgcggcctc ctcgggaacg ggggccgagc tcgccttcga ctccggcccc
    20581 tggacggacg cgctgacctg gccgcgatgc tcccagaaga ccagatccca atgcgccgtc
    20641 gcgaccgccg tcatctgctc gacgtcgcgg ctgctgctcc gccacacccg ctcgatgtac
    20701 ggcgagtcgg acgaccggct ctcgatgtcc aggcccatcc gggtcacacc cccctcaatc
    20761 gcccgtgcgc gccgaacctc gcggaagacc ggcccagatc attttccctg agccgggcaa
    20821 gggcgcgacc tcaccggtct cacggtcgcc gcgggcacgg aacacctgtt cggtggggtc
    20881 cggtgccccg tcgtcccgaa ggcgatcggt gagaaggaag tcgtccagtc cgaactcgcc
    20941 ggcgtgttcg ctctcgctca ggaagaaggt cccgccggcg aggtcgggat cccagccatg
    21001 cgtcaaggcg tagtcgacga ctctccgcac atccttcgga gtcgggtagg cgcagtcggt
    21061 cgcgcacccc cacggcagca cggccgtgga caacagatcc gcctggagca cgcggccgtt
    21121 cttcccggca ccccagacgc gaaggcggac gcatcggtga cagtcacgct cgcctgccac
    21181 gtgattgatc tgcgccgtcc acgcgaactc ccggccgcct gcgtgcagcc tccgcaacct
    21241 cgtccgcacg ctgatcaccc cacctcgtcg atttcatccg atatcgccgt acggatgacc
    21301 aacaggagta ttcgcagccc ccgaggtgac tggcaatcgg atttccggac gggtggcaga
    21361 tcggaccgga gtcagagggc acccgccggg acccacaccg tcaccggcgc cgctgaggga
    21421 cggatcacgg accgctcggg ccgatccggg tgttgcggag gtgctcgtag acgatcgacg
    21481 tgcggacgtc ggcgacttcg ggccgttcgg tgagcttgtc gatcacgaac gcgtacaggc
    21541 tggcattgtc cggcaccgcg acgtgcacga tgaagtcctc cgtgcccgtc gtcacgtaga
    21601 cgcccagggt gtcggggagc gcgctgaccc agttgcggaa gccctcgatg ttgcgccgcg
    21661 aggggggacg tacgcggatg gcgatgaggg cctggaccgg acgcccgatc gccgcgaggt
    21721 cgacgtcgag gatcgctccc cgaatgacgc cgcgctgccg gagcgcccgc gtacggtcga
    21781 gtgccgtggt cggcgagacc ccgaccgcgg cggcgacgtc acggttggtc ttccgtgcat
    21841 ccgactgcag ttccgccagg atcgccttat caagttcgtc catgcccgcc tctacgcccc
    21901 ttcttccgat ataagtacgg attccttgca gtccaatcgt atgggtgcct agcattttcg
    21961 ccgtactgcc ggatggatga ataggaggcc gggatgacgg ccgatgaagg tgcgaccacg
    22021 ggtgtcgggt tcgcccccga agagatcgac ccggccctcc cgacccgggc ggctcgcctc
    22081 aagtgggtga tcgtggtcga cggcgacctt cccgcgggcc gtgccgtgaa cgccgccgtc
    22141 tgcgtggccg cggcgacctc tacggcggtg accgggctcc tcggtgacga cgcggtggac
    22201 gccgacggcg gtgcgcaccc gggcctgccc tgggcggggt gttcggtgct ggccgcggac
    22261 accgccacgc ttcgtgccat ccgcaccaag gccgcggcgt ccgccggctg cttcgtggcg
    22321 gacatgcccg ccgcggccca gcggacgcgg gtctacgccg actatctcgc cacgatgaag
    22381 gagaccgcgg ccggcgacgt cgagtattac gcggtcagcg tggtcgggcc gcgcaaccgg
    22441 gtggacaaga tcgtgggaaa actgcccctg atgccgtgac ccggcatccc ggcgacggtc
    22501 aggagccggg cgagcgcagg tggcgggtgt ccacccggtg ccccgcatcc tccagtacgg
    22561 cgaccgcctc cttgatcctc ggctcgggca cgaggaccag gtcggcgtgg aacgtcgagg
    22621 cgacgaacac cgggacggcc gcatcggcca gcgggcccac gatggccgcc agcatgcccg
    22681 ggacgtccag gtggtgtccc gtttccccgc cgtacaggcc gatccagcgg tcgccggacc
    22741 ccgtcggcca ggcctcgcgg atcacggtga ggccctccgg ggcgcgtacg agcgcgatcc
    22801 agtcgtcgtc ctcggggaac gtcgcctgcg gcaggtgctg gacggcgaac acggacggca
    22861 cgatgccgag ccgctgggcg gcgggtgagg tcataaggcg tgtgtagcag agccctccga
    22921 caacacacct agacctggga ccactcggtg acggaggcga ccagcagcgg cccggcgaag
    22981 gagtccgcgg cgagggtcac cccggtgatc ctggcggcga gcgcgaacgc cttcgggagc
    23041 gcgtcgtccc accgcacgtc ccaggccgcc ttaccggccg tggcggtcag cggcagcccg
    23101 accctgcgca tcggctcctt cagccgatcg gggtcgctgc cccggcggtt gaccgacgcg
    23161 tgcggcgtga acgcggtgac gatctcgccg tccacggcgt acaggaagct gtg
//
