GCF_013875015.1 - 15 region(s)

Download region SVG

Location: 160,702 - 242,209 nt. (total: 81,508 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

H1Q60_RS00970: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

H1Q60_RS01050: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS01075: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

H1Q60_RS01080: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

H1Q60_RS01090: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS01095: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS01100: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS01145: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

H1Q60_RS01170: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Transferases: acylase transferase

H1Q60_RS01120: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

H1Q60_RS01195: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: deacetylase hydrolase

H1Q60_RS01055: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

H1Q60_RS01190: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Lyases: hydratase

H1Q60_RS01065: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

H1Q60_RS01070: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

H1Q60_RS01085: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

H1Q60_RS01105: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.73	PKS	difficidin	Bacillus velezensis FZB42
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0000174.5	0.60	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002056.3	0.57	NRPS, PKS	peloruside A	sponge metagenome
BGC0001795.3	0.53	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0000067.5	0.53	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3	0.52	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.73	PKS	difficidin	Bacillus velezensis FZB42
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0000174.5	0.60	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002056.3	0.57	NRPS, PKS	peloruside A	sponge metagenome
BGC0001795.3	0.53	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0000067.5	0.53	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3	0.52	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31

Confidence: medium

Additional weak hits (10):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 160701 - 242209:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal - ccmal - ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:: H1Q60_RS01095 + H1Q60_RS01090 + H1Q60_RS01085 + H1Q60_RS01080

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

H1Q60_RS01105: X

AMP-binding (15..363): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
Nearest Stachelhaus code(s):: 2,3-dohHda IGNPTGTIMK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

H1Q60_RS01120: mal

PKS_AT (4..281): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.7
inactive: 30.9
Methoxymalonyl-CoA: 29.3
Methylmalonyl-CoA: 21.7
Propionyl-CoA: 16.5
2-Methylbutyryl-CoA: 15.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
ToxT	Regulator of MSHA biosynthesis

NZ_CP059405.1 - Region 2 - terpene-precursor

Download region SVG

Location: 265,525 - 286,415 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

H1Q60_RS01430: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

H1Q60_RS01395: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

H1Q60_RS01400: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

H1Q60_RS01400: PT_FPPS_like

Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
SypG	Regulator of biofilm formation and host colonization

NZ_CP059405.1 - Region 3 - NRP-metallophore,NRPS,RiPP-like,terpene-precursor

Download region SVG

Location: 892,873 - 958,277 nt. (total: 65,405 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

H1Q60_RS04810: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS04885: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS04935: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

H1Q60_RS04940: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

H1Q60_RS04990: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase

H1Q60_RS04985: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: esterase hydrolase

H1Q60_RS04730: thioesterase superfamily protein

smcogs: SMCOG1144: thioesterase superfamily protein

H1Q60_RS04775: isochorismatase

smcogs: SMCOG1027: isochorismatase

H1Q60_RS04870: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

H1Q60_RS04880: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthetase

H1Q60_RS04750: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

H1Q60_RS04865: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

H1Q60_RS04875: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	2.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	1.60	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	1.07	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	1.04	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.87	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.86	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.95	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	0.93	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.81	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.80	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

H1Q60_RS04750: PT_FPPS_like

Domain 1 (62 - 307): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (19):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.88 out of 29.51

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.86 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.11 out of 33.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 892872 - 958277:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 906484 - 958221:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

H1Q60_RS04865: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1513..1929): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

H1Q60_RS04875: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SISLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (100% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP059405.1 - Region 4 - other

Download region SVG

Location: 1,480,831 - 1,522,249 nt. (total: 41,419 nt) Show pHMM detection rules used

other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

H1Q60_RS07750: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS07770: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS07805: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase

H1Q60_RS07755: aminotransferase

smcogs: SMCOG1019: aminotransferase

H1Q60_RS07855: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Lyases: dehydratase lyase

H1Q60_RS07765: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

H1Q60_RS07845: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

H1Q60_RS07850: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease

H1Q60_RS07660: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

H1Q60_RS07795: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000888.5	0.96	other (other)	bacilysin	Bacillus sp. CS93
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000790.3	0.52	saccharide	O-antigen	Escherichia coli
BGC0000773.3	0.52	saccharide	lipopolysaccharide	Escherichia coli
BGC0000791.3	0.52	saccharide	O-antigen	Cronobacter sakazakii
BGC0001928.2	0.51	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000813.3	0.51	other (other)	K-252a	Nonomuraea longicatena
BGC0000899.4	0.50	saccharide	desosamine	Streptomyces narbonensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000888.5	0.96	other (other)	bacilysin	Bacillus sp. CS93
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000790.3	0.52	saccharide	O-antigen	Escherichia coli
BGC0000773.3	0.52	saccharide	lipopolysaccharide	Escherichia coli
BGC0000791.3	0.52	saccharide	O-antigen	Cronobacter sakazakii
BGC0001928.2	0.51	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000813.3	0.51	other (other)	K-252a	Nonomuraea longicatena
BGC0000899.4	0.50	saccharide	desosamine	Streptomyces narbonensis

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.12 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.49 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.26 out of 29.38

Confidence: medium

Additional weak hits (7):

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.65 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.68 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_CP059405.1 - Region 5 - RiPP-like

Download region SVG

Location: 1,711,298 - 1,724,376 nt. (total: 13,079 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

H1Q60_RS08845: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.46	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000619.3	0.45	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.45	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.45	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0001864.3	0.44	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.46	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000619.3	0.45	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.45	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.45	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0001864.3	0.44	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

Additional weak hits (7):

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.03 out of 20.47

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.31 out of 25.88

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.12 out of 30.25

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.12 out of 36.53

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.31 out of 25.88

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_CP059405.1 - Region 6 - azole-containing-RiPP

Download region SVG

Location: 2,153,532 - 2,183,268 nt. (total: 29,737 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: glucosidase hydrolase

H1Q60_RS11200: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

H1Q60_RS11215: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Lyases: dehydratase

H1Q60_RS11235: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Translocases: permease

H1Q60_RS11305: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002311.3	0.51	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0001146.5	0.50	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000606.5	0.49	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001174.4	0.47	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000605.5	0.46	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000607.5	0.45	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000565.5	0.44	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001640.3	0.43	ribosomal	kocurin	Kocuria rosea
BGC0000613.5	0.43	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002311.3	0.51	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0001146.5	0.50	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000606.5	0.49	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001174.4	0.47	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000605.5	0.46	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000607.5	0.45	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000565.5	0.44	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001640.3	0.43	ribosomal	kocurin	Kocuria rosea
BGC0000613.5	0.43	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.40 out of 27.78

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.62 out of 26.06

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.71 out of 26.33

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

Additional weak hits (1):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.34 out of 33.14

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

Core peptide predictions

No core peptides found.

NZ_CP059405.1 - Region 7 - NRPS

Download region SVG

Location: 2,194,623 - 2,260,030 nt. (total: 65,408 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase electron transfer oxidoreductase reductase

H1Q60_RS11375: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

H1Q60_RS11390: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

H1Q60_RS11395: flavodoxin

smcogs: SMCOG1134: flavodoxin

H1Q60_RS11400: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

H1Q60_RS11415: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

H1Q60_RS11565: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase

H1Q60_RS11480: aminotransferase

smcogs: SMCOG1019: aminotransferase

H1Q60_RS11485: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

H1Q60_RS11475: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

H1Q60_RS11410: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

H1Q60_RS11460: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

H1Q60_RS11470: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

H1Q60_RS21400: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

H1Q60_RS21410: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000433.5	0.85	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000433.5	0.85	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (16):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.23 out of 36.54

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.84 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.78 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.63 out of 36.54

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.92 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 23.04 out of 30.12

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 10, location 2194622 - 2260030:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu - D-Leu) + (Val) + (Asp - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

H1Q60_RS11460: Glu - Leu - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2550..2939): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

H1Q60_RS21400: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

H1Q60_RS21410: Asp - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (429..831): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1474..1863): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

H1Q60_RS11470: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
Nearest Stachelhaus code(s):: Leu DAFFLGCVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP059405.1 - Region 8 - lassopeptide

Download region SVG

Location: 2,555,134 - 2,577,611 nt. (total: 22,478 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

H1Q60_RS13170: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001655.3	0.51	ribosomal	LP2006	Nocardiopsis alba DSM 43377
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001176.4	0.51	ribosomal	streptomonomicin	Streptomonospora alba
BGC0000571.3	0.49	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001779.5	0.47	ribosomal	siamycin	Streptomyces nodosus
BGC0001639.3	0.46	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001920.4	0.46	ribosomal	siamycin I	Streptomyces sp.
BGC0001674.5	0.46	ribosomal	MS-271	Streptomyces mirabilis
BGC0000579.4	0.46	ribosomal	SSV-2083	Streptomyces sviceus ATCC 29083
BGC0002307.3	0.46	ribosomal	humidimycin	Streptomyces humidus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001655.3	0.51	ribosomal	LP2006	Nocardiopsis alba DSM 43377
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001176.4	0.51	ribosomal	streptomonomicin	Streptomonospora alba
BGC0000571.3	0.49	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001779.5	0.47	ribosomal	siamycin	Streptomyces nodosus
BGC0001639.3	0.46	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001920.4	0.46	ribosomal	siamycin I	Streptomyces sp.
BGC0001674.5	0.46	ribosomal	MS-271	Streptomyces mirabilis
BGC0000579.4	0.46	ribosomal	SSV-2083	Streptomyces sviceus ATCC 29083
BGC0002307.3	0.46	ribosomal	humidimycin	Streptomyces humidus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.63 out of 26.85

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

Additional weak hits (3):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.47 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.85 out of 32.74

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 2 - 85; Score: 48.6

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
RutR	Regulator of the pyrimidine and purine metabolism

NZ_CP059405.1 - Region 9 - PKS-like

Download region SVG

Location: 2,855,495 - 2,896,739 nt. (total: 41,245 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

H1Q60_RS14805: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase

H1Q60_RS14835: acyltransferase

smcogs: SMCOG1141: acyltransferase

H1Q60_RS14850: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: deacetylase

H1Q60_RS14895: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

H1Q60_RS14855: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

H1Q60_RS14810: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002294.3	0.44	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001206.5	0.42	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002294.3	0.44	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001206.5	0.42	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.49 out of 25.88

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

Additional weak hits (13):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.22 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP059405.1 - Region 10 - terpene

Download region SVG

Location: 2,969,141 - 2,989,881 nt. (total: 20,741 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

H1Q60_RS15395: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: aminotransferase

H1Q60_RS15410: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: hydrolase

H1Q60_RS15370: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001374.5	0.42	other (other)	thienodolin	Streptomyces albogriseolus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001488.3	0.38	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000720.3	0.35	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001810.3	0.35	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001374.5	0.42	other (other)	thienodolin	Streptomyces albogriseolus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001488.3	0.38	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000720.3	0.35	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001810.3	0.35	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

H1Q60_RS15375: PT_phytoene_like

Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → squalene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19

Confidence: medium

Additional weak hits (6):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.48 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.91 out of 32.74

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
NrtR	NAD synthesis repressor
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor

NZ_CP059405.1 - Region 11 - lanthipeptide-class-ii

Download region SVG

Location: 3,160,400 - 3,183,285 nt. (total: 22,886 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

H1Q60_RS16395: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

H1Q60_RS16415: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.54	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000527.5	0.52	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000516.4	0.51	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000532.3	0.51	ribosomal	mutacin II	Streptococcus mutans
BGC0000500.5	0.47	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000499.3	0.47	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus
BGC0001555.4	0.46	ribosomal	colicin V	Escherichia coli chi7122
BGC0001311.5	0.46	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.54	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000527.5	0.52	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000516.4	0.51	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000532.3	0.51	ribosomal	mutacin II	Streptococcus mutans
BGC0000500.5	0.47	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000499.3	0.47	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus
BGC0001555.4	0.46	ribosomal	colicin V	Escherichia coli chi7122
BGC0001311.5	0.46	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for H1Q60_RS16395

H1Q60_RS16390

Leader:

MNEKMYRFAGDLREELEEISLS

Core:

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

Core with dehydrations:

EFDhaGGGGAEQRGIDhaQGNDGKLCysDhbLDhbWECysGLCysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for H1Q60_RS16390

100.0%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

97.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTC+C

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCFC

38

86.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

33

with 92 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTC-WC

38

AEQRGISQGNDGK CTLTWEC +CPT TC WC

1

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

32

68.4%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AEQRGISQGNDG CT+TWEC +CPTHTCWC

1

AEQRGISQGNDGHQCTITWECSICPTHTCWC

31

68.4%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE RGISQGNDG CT+TWECG+CPTHTCWC

3

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

33

68.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE +G+SQGNDGK+CTLTWECGLCPTHTC+C

1

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

31

65.8%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKYCTITWECSICPTHTCWC

32

65.8%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKWCTVTWECSICPTHTCWC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

E RG+SQGNDG CT+TWECG+CPTHTCWC

1

ADVETRGLSQGNDGDYCTITWECGMCPTHTCWC

33

63.2%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GIS+ NDGK CTLTWEC +CPTHTCWC

1

AAEPMGISEDNDGKYCTLTWECSICPTHTCWC

32

63.2%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

1

ADVQGISQGNDGKYCTITWECSICPTHTCWC

31

55.3%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

G G R +S+GN GK+CTLTWECG+CP+HTC+

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

MIBiG 4.0 matches for H1Q60_RS16390

23.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: haloduracin β or haloduracin α

16

GNDGKLCTLTWEC

28

GN G CTLT EC

11

GNKGAYCTLTVEC

23

23.7%

Lanthipeptide: birimositide

16

GNDGKLCTLTWEC

28

GN+G CTLT EC

13

GNNGGWCTLTKEC

25

15.8%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

6

GGAEQRGISQ

15

GG GISQ

10

GGITTLGISQ

19

with 1 more sequence matches

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

22

CTLTWEC

28

CTL+ EC

28

CTLSKEC

34

H1Q60_RS16405

Leader:

MKKEFLALELMTEEELKELAGG

Core:

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaEADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for H1Q60_RS16405

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide

Lanthipeptides: J7E20_RS10240_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+A PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

66.7%

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCN

35

+E+TP TP TI IP+SLA CPTT+CASIV CN

1

AESTP-NGTPATI-IPVSLAICPTTRCASIVESCN

33

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

61.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

2

EATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

+ATP T PTTI IP+SLA CPTT C S SPC

2

DATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

60.5%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

60.5%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

MIBiG 4.0 matches for H1Q60_RS16405

24.3%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

H1Q60_RS16410

Leader:

MKKDFQALTPMTEEELKNLAGG

Core:

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaDADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for H1Q60_RS16410

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

94.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDA PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

66.7%

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

DATP T PTTI IP+SLA CPTT C S SPC

1

EDATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

63.2%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

55.6%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVS CN

6

TIIIPISLAACPTTRCASIVSSCN

29

55.6%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTT+CASIV CN

8

TPATI-IPVSLAICPTTRCASIVESCNG

34

MIBiG 4.0 matches for H1Q60_RS16410

24.3%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

allorf_3169717_3169899

Leader:

MKGGEIWNMKKNFSALYETSEQELKELVGG

Core:

QNSVSITTYPITNHICPTITVGCACPQRQV

Core with dehydrations:

QNDhaVDhaIDhbDhbYPIDhbNHICysPDhbIDhbVGCysACysPQRQV

antiSMASH-DB 4.0 matches for allorf_3169717_3169899

100.0%

NZ_CP016371.1and 25 others:

NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide

Lanthipeptides: allorf_1203980_1204162_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITTYPITNHICPTITVGCACPQRQV

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

93.3%

NC_023073.1and 18 others:

NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide

Lanthipeptides: allorf_1238739_1238921_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITT PITNH+CPTITVGCACPQRQV

1

QNSVSITTIPITNHVCPTITVGCACPQRQV

30

66.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide

Lanthipeptides: J7E20_RS10235_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QN +SITT P T H+C T+TVGCACPQ+Q+

1

QNLISITTIPFT-HLCATVTVGCACPQKQI

29

with 3 more sequence matches

23.5%

NZ_CP048048.1and 2 others:

NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptideNZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide

Lanthipeptides: GW571_RS15175_lanthipeptide

8

TYPITNHICPTITVGCACPQRQ

29

T+ +T +C TI AC Q

8

TFKLTVKVCRTIITTTACGSTQ

29

20.0%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

11

ITNHICPTI

19

TN +CPTI

15

FTNRLCPTI

23

15.8%

NZ_KB907258.1:

Lanthipeptides: G358_RS0114910_lanthipeptide

2

NSVSITTYPITNHICPTIT

20

NS+ I+ Y + CP++

6

NSIRISIYKCLSLFCPSVA

24

MIBiG 4.0 matches for allorf_3169717_3169899

13.3%

Lanthipeptide: haloduracin β or haloduracin α

18

TITVGC

23

T+TV C

18

TLTVEC

23

allorf_3176215_3176292

Leader:

MRIHSIFIRMQGLYA

Core:

QVICPTNATY

Core with dehydrations:

QVICysPDhbNADhbY

antiSMASH-DB 4.0 matches for allorf_3176215_3176292

100.0%

NZ_CP016371.1and 22 others:

NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide

Lanthipeptides: allorf_1210473_1210550_lanthipeptide

1

QVICPTNATY

10

QVICPTNATY

1

QVICPTNATY

10

Lanthipeptide(s) for H1Q60_RS16415

H1Q60_RS16390

Leader:

MNEKMYRFAGDLREELEEISLS

Core:

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

Core with dehydrations:

EFDhaGGGGAEQRGIDhaQGNDGKLCysDhbLDhbWECysGLCysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for H1Q60_RS16390

100.0%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

97.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTC+C

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCFC

38

86.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

33

with 92 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTC-WC

38

AEQRGISQGNDGK CTLTWEC +CPT TC WC

1

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

32

68.4%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AEQRGISQGNDG CT+TWEC +CPTHTCWC

1

AEQRGISQGNDGHQCTITWECSICPTHTCWC

31

68.4%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE RGISQGNDG CT+TWECG+CPTHTCWC

3

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

33

68.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE +G+SQGNDGK+CTLTWECGLCPTHTC+C

1

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

31

65.8%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKYCTITWECSICPTHTCWC

32

65.8%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKWCTVTWECSICPTHTCWC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

E RG+SQGNDG CT+TWECG+CPTHTCWC

1

ADVETRGLSQGNDGDYCTITWECGMCPTHTCWC

33

63.2%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GIS+ NDGK CTLTWEC +CPTHTCWC

1

AAEPMGISEDNDGKYCTLTWECSICPTHTCWC

32

63.2%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

1

ADVQGISQGNDGKYCTITWECSICPTHTCWC

31

55.3%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

G G R +S+GN GK+CTLTWECG+CP+HTC+

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

MIBiG 4.0 matches for H1Q60_RS16390

23.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: haloduracin β or haloduracin α

16

GNDGKLCTLTWEC

28

GN G CTLT EC

11

GNKGAYCTLTVEC

23

23.7%

Lanthipeptide: birimositide

16

GNDGKLCTLTWEC

28

GN+G CTLT EC

13

GNNGGWCTLTKEC

25

15.8%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

6

GGAEQRGISQ

15

GG GISQ

10

GGITTLGISQ

19

with 1 more sequence matches

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

22

CTLTWEC

28

CTL+ EC

28

CTLSKEC

34

H1Q60_RS16405

Leader:

MKKEFLALELMTEEELKELAGG

Core:

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaEADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for H1Q60_RS16405

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide

Lanthipeptides: J7E20_RS10240_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+A PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

66.7%

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCN

35

+E+TP TP TI IP+SLA CPTT+CASIV CN

1

AESTP-NGTPATI-IPVSLAICPTTRCASIVESCN

33

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

61.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

2

EATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

+ATP T PTTI IP+SLA CPTT C S SPC

2

DATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

60.5%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

60.5%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

MIBiG 4.0 matches for H1Q60_RS16405

24.3%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

H1Q60_RS16410

Leader:

MKKDFQALTPMTEEELKNLAGG

Core:

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaDADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for H1Q60_RS16410

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

94.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDA PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

66.7%

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

DATP T PTTI IP+SLA CPTT C S SPC

1

EDATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

63.2%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

55.6%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVS CN

6

TIIIPISLAACPTTRCASIVSSCN

29

55.6%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTT+CASIV CN

8

TPATI-IPVSLAICPTTRCASIVESCNG

34

MIBiG 4.0 matches for H1Q60_RS16410

24.3%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

H1Q60_RS16480

Leader:

MCKLCGPKKVIVTETGFGA

Core:

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

Core with dehydrations:

VFHPCysPNCysKDhbGDhbDLDhbPVIKRLERMVQDAKARLDARV

antiSMASH-DB 4.0 matches for H1Q60_RS16480

100.0%

NC_023073.1and 25 others:

NZ_CP010556.1 Lanthipeptides: SB45_RS19805_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19795_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20400_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22075_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS21000_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21480_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19740_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19585_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20470_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21110_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20035_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16480_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06705_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18975_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06485_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16830_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06200_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12895_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06150_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06335_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11720_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03045_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19745_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19365_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18850_lanthipeptide

Lanthipeptides: U722_RS20005_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

97.2%

NZ_CP025341.1:

Lanthipeptides: CXR48_RS19565_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLD RV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDLRV

36

89.7%

NZ_CP023075.1and 8 others:

NZ_CP035393.1 Lanthipeptides: ES966_RS21105_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20970_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19665_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17705_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03370_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01895_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00520_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122700_lanthipeptide

Lanthipeptides: CK238_RS20695_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAK RLDARV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARV

36

with 2 more sequence matches

22.2%

NC_015600.1and 17 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP024974.1 Lanthipeptides: CVO91_RS06555_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAMDIB010000004.1 Lanthipeptides: M5P35_RS04030_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

6

PNCKTGTDLTPVIK

19

P CKTG +T IK

9

PGCKTGILMTCAIK

22

22.2%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

6

PNCKTGTDLTPVIK

19

P CKTG +T IK

9

PGCKTGALMTCPIK

22

MIBiG 4.0 matches for H1Q60_RS16480

13.9%

Lanthipeptide: nisin A

6

PNCKTG

11

P CKTG

9

PGCKTG

14

allorf_3169717_3169899

Leader:

MKGGEIWNMKKNFSALYETSEQELKELVGG

Core:

QNSVSITTYPITNHICPTITVGCACPQRQV

Core with dehydrations:

QNDhaVDhaIDhbDhbYPIDhbNHICysPDhbIDhbVGCysACysPQRQV

antiSMASH-DB 4.0 matches for allorf_3169717_3169899

100.0%

NZ_CP016371.1and 25 others:

NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide

Lanthipeptides: allorf_1203980_1204162_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITTYPITNHICPTITVGCACPQRQV

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

93.3%

NC_023073.1and 18 others:

NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide

Lanthipeptides: allorf_1238739_1238921_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITT PITNH+CPTITVGCACPQRQV

1

QNSVSITTIPITNHVCPTITVGCACPQRQV

30

66.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide

Lanthipeptides: J7E20_RS10235_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QN +SITT P T H+C T+TVGCACPQ+Q+

1

QNLISITTIPFT-HLCATVTVGCACPQKQI

29

with 3 more sequence matches

23.5%

NZ_CP048048.1and 2 others:

NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptideNZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide

Lanthipeptides: GW571_RS15175_lanthipeptide

8

TYPITNHICPTITVGCACPQRQ

29

T+ +T +C TI AC Q

8

TFKLTVKVCRTIITTTACGSTQ

29

20.0%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

11

ITNHICPTI

19

TN +CPTI

15

FTNRLCPTI

23

15.8%

NZ_KB907258.1:

Lanthipeptides: G358_RS0114910_lanthipeptide

2

NSVSITTYPITNHICPTIT

20

NS+ I+ Y + CP++

6

NSIRISIYKCLSLFCPSVA

24

MIBiG 4.0 matches for allorf_3169717_3169899

13.3%

Lanthipeptide: haloduracin β or haloduracin α

18

TITVGC

23

T+TV C

18

TLTVEC

23

allorf_3176215_3176292

Leader:

MRIHSIFIRMQGLYA

Core:

QVICPTNATY

Core with dehydrations:

QVICysPDhbNADhbY

antiSMASH-DB 4.0 matches for allorf_3176215_3176292

100.0%

NZ_CP016371.1and 22 others:

NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide

Lanthipeptides: allorf_1210473_1210550_lanthipeptide

1

QVICPTNATY

10

QVICPTNATY

1

QVICPTNATY

10

allorf_3178400_3178561

Leader:

MNRGARFYIHWSYAAQEVLGG

Core:

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

Core with dehydrations:

QHGENDhaVMMQKPFLRFKMMDhbFCysRLRFKPAENR

antiSMASH-DB 4.0 matches for allorf_3178400_3178561

100.0%

NZ_CP017775.1and 9 others:

NZ_CP023075.1 Lanthipeptides: allorf_1289301_1289462_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1371482_1371643_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2629421_2629582_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3178400_3178561_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_113041_113202_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0702092_0702253_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03015_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122870_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_335356_335517_lanthipeptide

Lanthipeptides: allorf_1372345_1372506_lanthipeptide

1

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

32

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

1

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

32

40.6%

NC_023073.1and 9 others:

NZ_CP016395.1 Lanthipeptides: BBJ33_RS20395_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21475_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19560_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19590_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20475_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06455_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06170_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06305_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19360_lanthipeptide

Lanthipeptides: U722_RS20000_lanthipeptide

1

QHGENSVMMQKPFLR

15

QHG+ SVMMQKPFLR

1

QHGDYSVMMQKPFLR

15

21.9%

NZ_JXCA02000027.1:

Lanthipeptides: allorf_403131_403280_lanthipeptide

10

QKPFLRFKMMTFC

22

Q PFLR + FC

12

QPPFLREGLCKFC

24

with 1 more sequence matches

15.2%

NZ_KB235948.1:

Lanthipeptides: OSC10802_RS0121020_lanthipeptide

15

RFKMMTFCRLRFKPAENR

32

RF C+ F PA+ R

11

RFMKAMLCKDSFSPADRR

28

allorf_3182941_3183042

Leader:

MSYVCHLEVNRRSQKAARLEAA

Core:

FYYRQSCRRWR

Core with dehydrations:

FYYRQDhaCysRRWR

antiSMASH-DB 4.0 matches for allorf_3182941_3183042

100.0%

NC_023073.1and 25 others:

NZ_CP010556.1 Lanthipeptides: allorf_1184096_1184197_lanthipeptideNZ_CP016371.1 Lanthipeptides: allorf_1217185_1217286_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1280116_1280217_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1237649_1237750_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0814210_0814311_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1220484_1220585_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2632526_2632603_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1156108_1156209_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3744466_3744567_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3531374_3531475_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1298847_1298948_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3182941_3183042_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1285088_1285189_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3842801_3842902_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1242067_1242168_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3353378_3353479_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1233992_1234093_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2689692_2689793_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1187843_1187944_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1214408_1214509_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1148352_1148453_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2196063_2196164_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0358200_0358301_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1199095_1199196_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_330876_330977_lanthipeptide

Lanthipeptides: allorf_1251961_1252062_lanthipeptide

1

FYYRQSCRRWR

11

FYYRQSCRRWR

1

FYYRQSCRRWR

11

5.9%

NZ_FMXV01000022.1:

Lanthipeptides: allorf_002190_002423_lanthipeptide

3

YRQSCRRWR

11

+ ++C RWR

57

WERACSRWR

65

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.27 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.65 out of 24.78

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.07 out of 24.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 28.19

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.57 out of 20.01

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (3):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.13 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.99 out of 29.65

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

H1Q60_RS16390 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3892.7 Da

Molecular weight: 3895.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3913.3 Da N = 1

H1Q60_RS16405 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3403.7 Da

Molecular weight: 3405.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3423.9 Da N = 1; 3442.0 Da N = 2; 3460.0 Da N = 3; 3478.0 Da N = 4; 3496.0 Da N = 5; 3514.0 Da N = 6; 3532.1 Da N = 7; 3550.1 Da N = 8; 3568.1 Da N = 9

H1Q60_RS16410 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3389.7 Da

Molecular weight: 3391.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3409.9 Da N = 1; 3427.9 Da N = 2; 3446.0 Da N = 3; 3464.0 Da N = 4; 3482.0 Da N = 5; 3500.0 Da N = 6; 3518.0 Da N = 7; 3536.1 Da N = 8; 3554.1 Da N = 9

H1Q60_RS16480 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 4023.2 Da

Molecular weight: 4025.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4043.7 Da N = 1

allorf_3169717_3169899 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3117.6 Da

Molecular weight: 3119.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3137.6 Da N = 1; 3155.6 Da N = 2; 3173.6 Da N = 3; 3191.6 Da N = 4

allorf_3176215_3176292 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1072.5 Da

Molecular weight: 1073.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1091.2 Da N = 1

allorf_3178400_3178561 - Class II

Cleavage pHMM score: -2.00

RODEO score: 0

Monoisotopic mass: 3921.0 Da

Molecular weight: 3923.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3941.7 Da N = 1

allorf_3182941_3183042 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1601.8 Da

Molecular weight: 1602.8 Da

Number of bridges: 1

H1Q60_RS16390 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3892.7 Da

Molecular weight: 3895.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3913.3 Da N = 1

H1Q60_RS16405 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3403.7 Da

Molecular weight: 3405.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3423.9 Da N = 1; 3442.0 Da N = 2; 3460.0 Da N = 3; 3478.0 Da N = 4; 3496.0 Da N = 5; 3514.0 Da N = 6; 3532.1 Da N = 7; 3550.1 Da N = 8; 3568.1 Da N = 9

H1Q60_RS16410 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3389.7 Da

Molecular weight: 3391.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3409.9 Da N = 1; 3427.9 Da N = 2; 3446.0 Da N = 3; 3464.0 Da N = 4; 3482.0 Da N = 5; 3500.0 Da N = 6; 3518.0 Da N = 7; 3536.1 Da N = 8; 3554.1 Da N = 9

allorf_3169717_3169899 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3117.6 Da

Molecular weight: 3119.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3137.6 Da N = 1; 3155.6 Da N = 2; 3173.6 Da N = 3; 3191.6 Da N = 4

allorf_3176215_3176292 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1072.5 Da

Molecular weight: 1073.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1091.2 Da N = 1

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
ArgR	Regulator of arginine biosynthesis genes
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP059405.1 - Region 12 - transAT-PKS

Download region SVG

Location: 3,334,831 - 3,423,053 nt. (total: 88,223 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

H1Q60_RS17390: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS17400: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS17405: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS17415: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS17445: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase kinase

H1Q60_RS17285: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

H1Q60_RS17385: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deformylase hydrolase phosphatase

H1Q60_RS17365: hydrolase

smcogs: SMCOG1179: hydrolase

H1Q60_RS17370: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

H1Q60_RS17420: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

H1Q60_RS17425: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

H1Q60_RS17485: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Ligases: synthase

H1Q60_RS17395: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

H1Q60_RS17435: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.89	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.89	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.89	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.89	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.16 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

Additional weak hits (7):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.44 out of 31.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 15, location 3334830 - 3423053:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:: H1Q60_RS17390 + H1Q60_RS17395 + H1Q60_RS17400 + H1Q60_RS17405 + H1Q60_RS17410 + H1Q60_RS17415 + H1Q60_RS17420

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

H1Q60_RS17385: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 92.6
inactive: 32.0
Methoxymalonyl-CoA: 28.0
Methylmalonyl-CoA: 20.8
Propionyl-CoA: 17.4
fatty_acid: 13.9
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP059405.1 - Region 13 - NRPS,T3PKS,transAT-PKS

Download region SVG

Location: 3,689,720 - 3,779,382 nt. (total: 89,663 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

H1Q60_RS18880: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

H1Q60_RS19005: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase

H1Q60_RS18945: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

H1Q60_RS18950: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase protease

H1Q60_RS18860: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

H1Q60_RS18935: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

H1Q60_RS19025: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase

H1Q60_RS18965: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

H1Q60_RS18970: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

H1Q60_RS18885: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

H1Q60_RS18960: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

H1Q60_RS18975: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

H1Q60_RS18990: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

H1Q60_RS18995: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

H1Q60_RS19000: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	0.90	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0002192.3	0.89	PKS	FR901512	fungal sp. No.14919
BGC0001244.3	0.89	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.89	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.88	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.88	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002191.2	0.88	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000107.3	0.85	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.85	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.83	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	0.75	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0002192.3	0.65	PKS	FR901512	fungal sp. No.14919
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000107.3	0.64	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002175.3	0.64	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.29 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.10 out of 24.78

Confidence: strong

Additional weak hits (16):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.08 out of 39.62

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 16, location 3689719 - 3779382:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal - mal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

H1Q60_RS18945: mal

PKS_AT (7..293): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 38.6
inactive: 27.0
Methoxymalonyl-CoA: 19.2
Benzoyl-CoA: 11.5
Methylmalonyl-CoA: 9.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

H1Q60_RS18950: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.4
inactive: 28.2
Methoxymalonyl-CoA: 23.4
Methylmalonyl-CoA: 10.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

H1Q60_RS18995: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (492..896): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP059405.1 - Region 14 - NRPS,betalactone,transAT-PKS

Download region SVG

Location: 3,964,642 - 4,082,018 nt. (total: 117,377 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

H1Q60_RS20475: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

H1Q60_RS20495: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

H1Q60_RS20570: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acylase aminotransferase carboxylase transferase

H1Q60_RS20470: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

H1Q60_RS20515: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

H1Q60_RS20530: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

H1Q60_RS20540: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

H1Q60_RS20560: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase

H1Q60_RS20545: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

H1Q60_RS20455: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

H1Q60_RS20460: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

H1Q60_RS20465: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

H1Q60_RS20510: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

H1Q60_RS20550: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

H1Q60_RS20565: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

H1Q60_RS20585: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

H1Q60_RS20590: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

H1Q60_RS20595: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	1.50	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001833.4	1.49	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	1.45	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	1.45	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	1.45	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001825.4	1.42	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	1.42	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001098.5	1.41	NRPS, PKS	iturin	Bacillus subtilis
BGC0001758.4	1.39	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	1.35	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	0.88	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001098.5	0.84	NRPS, PKS	iturin	Bacillus subtilis
BGC0000402.4	0.80	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0001095.5	0.79	NRPS	fengycin	Bacillus velezensis FZB42
BGC0001103.5	0.79	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.72 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 27.55

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.01 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.17 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.51 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.20 out of 24.78

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.44 out of 32.93

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

Additional weak hits (14):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.51 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.08 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.85 out of 27.04

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 17, location 3964641 - >4082018:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 18, location 3964641 - 4041891:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 19, location 4024806 - >4082018:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X) + (Ile)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

H1Q60_RS20455: Ser - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (267..674): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1789..2188): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNNHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

H1Q60_RS20460: Tyr - Asn - Pro - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1779..2174): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3286..3683): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4325..4732): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

H1Q60_RS20465: fatty_acid - Asn

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 620.1
NH2: 18.6
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

H1Q60_RS20470: mal

PKS_AT (6..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 76.9
inactive: 33.0
Methoxymalonyl-CoA: 22.5
Methylmalonyl-CoA: 11.9
Propionyl-CoA: 10.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

H1Q60_RS20565: X

AMP-binding (12..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

H1Q60_RS20585: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (473..866): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

H1Q60_RS20590: Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (469..866): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

H1Q60_RS20595: X

AMP-binding (1..211): X

nrpys: Ala, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: ----FDVTTFEGWLIIGGEWNGYGPTENTTFSTC
Nearest Stachelhaus code(s):: Ala or Val DVFWIGGTFK (85% 8Å match); Val DVFWIGGTFK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
LexA variant 2	Repressor of DNA damage response
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP059405.1 - Region 15 - terpene