LOCUS       NZ_CP059405            20741 bp    DNA     circular CON 14-APR-2024
DEFINITION  Bacillus velezensis strain MV2 chromosome, complete genome.
ACCESSION   NZ_CP059405
VERSION     NZ_CP059405.1
KEYWORDS    RefSeq.
SOURCE      Bacillus velezensis
  ORGANISM  Bacillus velezensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus amyloliquefaciens group.
REFERENCE   1  (bases 1 to 4191702)
  AUTHORS   Chen,X.H., Koumoutsi,A., Scholz,R., Eisenreich,A., Schneider,K.,
            Heinemeyer,I., Morgenstern,B., Voss,B., Hess,W.R., Reva,O.,
            Junge,H., Voigt,B., Jungblut,P.R., Vater,J., Sussmuth,R.,
            Liesegang,H., Strittmatter,A., Gottschalk,G. and Borriss,R.
  TITLE     Comparative analysis of the complete genome sequence of the plant
            growth-promoting bacterium Bacillus amyloliquefaciens FZB42
  JOURNAL   Nat Biotechnol 25 (9), 1007-1014 (2007)
   PUBMED   17704766
REFERENCE   2  (bases 1 to 4191702)
  AUTHORS   Lee,H. and Jo,E.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JUL-2020) Microbiology, Pusan National University, 2,
            Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-JUL-2020
            Assembly Method                   :: HGAP v. 4.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 589.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013875015.1-RS_2024_04_14
            Annotation Date                   :: 04/14/2024 20:37:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,290
            CDSs (total)                      :: 4,172
            Genes (coding)                    :: 4,053
            CDSs (with protein)               :: 4,053
            Genes (RNA)                       :: 118
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 119
            CDSs (without protein)            :: 119
            Pseudo Genes (ambiguous residues) :: 0 of 119
            Pseudo Genes (frameshifted)       :: 56 of 119
            Pseudo Genes (incomplete)         :: 72 of 119
            Pseudo Genes (internal stop)      :: 19 of 119
            Pseudo Genes (multiple problems)  :: 24 of 119
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:30:14
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2969140
            Orig. end                         :: 2989881
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059405.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20741
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20741
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20741
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10741](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10741
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(38..53)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.48"
                     /tool="antismash"
     misc_feature    917..935
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.91"
                     /tool="antismash"
     misc_feature    948..963
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.1"
                     /tool="antismash"
     misc_feature    complement(1068..1082)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 20.88"
                     /tool="antismash"
     misc_feature    complement(2375..2389)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            2900..3193
                     /locus_tag="H1Q60_RS15315"
                     /old_locus_tag="H1Q60_15315"
     CDS             2900..3193
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017417418.1"
                     /locus_tag="H1Q60_RS15315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15315"
                     /product="hypothetical protein"
                     /protein_id="WP_017417418.1"
                     /transl_table=11
                     /translation="MADSAEGTCELCGRHHVRLTEHHLTPKEEGGTFLPTAMLCIPCHK
                     QVHALYTNQELAARLAGIEELRRDPKLARFVKWIRKQPPKKLVKTKKANERT"
     gene            complement(3237..3455)
                     /locus_tag="H1Q60_RS15320"
                     /old_locus_tag="H1Q60_15320"
     CDS             complement(3237..3455)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003155143.1"
                     /locus_tag="H1Q60_RS15320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15320"
                     /product="spore germination protein"
                     /protein_id="WP_003155143.1"
                     /transl_table=11
                     /translation="MPAITGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTGD
                     FLLLNNVVNATNYIDPDVSDQNVVGNA"
     gene            complement(3495..3890)
                     /locus_tag="H1Q60_RS15325"
                     /old_locus_tag="H1Q60_15325"
     CDS             complement(3495..3890)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007610514.1"
                     /locus_tag="H1Q60_RS15325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15325"
                     /product="spore germination protein GerPE"
                     /protein_id="WP_014417372.1"
                     /transl_table=11
                     /translation="MLKRISRLRNAKINSVGIASVFQAGDTNEINMRVKVLADQRSLAV
                     YRDDEGSFNKKEYQIFRQPAVMPLPETGVQSAFCHENPSIRVRNVKVQGVSSASVVQIG
                     STSIVLGDSRLKHIRQIFTSSSQSQQP"
     gene            complement(3890..4066)
                     /locus_tag="H1Q60_RS15330"
                     /old_locus_tag="H1Q60_15330"
     CDS             complement(3890..4066)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388950.1"
                     /locus_tag="H1Q60_RS15330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15330"
                     /product="hypothetical protein"
                     /protein_id="WP_003155141.1"
                     /transl_table=11
                     /translation="MIFTVINRNIEVGDIRSTGVSSSSLLLIGDTDSVYLSSIFDTPPE
                     SLIIGPYVPLAPE"
     gene            complement(4063..4680)
                     /locus_tag="H1Q60_RS15335"
                     /old_locus_tag="H1Q60_15335"
     CDS             complement(4063..4680)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388951.1"
                     /locus_tag="H1Q60_RS15335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15335"
                     /product="spore germination protein GerPC"
                     /protein_id="WP_017417419.1"
                     /transl_table=11
                     /translation="MYDQSVSSYLQNLNSFVQQQAQQIQELERQLKEFQNEISTLKQQP
                     STRIDRLEYKFDQLKIERLEGTLNIGLNPTDPNAVQNFEVGQTSPQVGMMQQEQAGQQM
                     QQIRQNVDMYLNEEIPALLEKLETQYESRLDEANKYHIIEDIRKQMDSRIKYYLSHVPK
                     EENTAPAQYAEQIAEHVKRDIVRAVEHFIKHIPGEMKGDDPS"
     gene            complement(4716..4952)
                     /locus_tag="H1Q60_RS15340"
                     /old_locus_tag="H1Q60_15340"
     CDS             complement(4716..4952)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015483061.1"
                     /locus_tag="H1Q60_RS15340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15340"
                     /product="spore germination protein GerPB"
                     /protein_id="WP_007409164.1"
                     /transl_table=11
                     /translation="MNFYVNQSIHINYMRVESVSNSSILQIGSAGSIKSLSNLYNTGSY
                     VEPAPPVTAGQQTVTTGGGPGTSSFVPLQPPSR"
     misc_feature    complement(4918..4931)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 23.16"
                     /tool="antismash"
     gene            complement(4965..5186)
                     /locus_tag="H1Q60_RS15345"
                     /old_locus_tag="H1Q60_15345"
     CDS             complement(4965..5186)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388953.1"
                     /locus_tag="H1Q60_RS15345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15345"
                     /product="spore germination protein"
                     /protein_id="WP_003155135.1"
                     /transl_table=11
                     /translation="MPAIVGAFKINAVGTSGVVHIGDCITISPKAEVKTFAGAGSFNTG
                     DNLTLTNYRNSTNVYDNDVIDQPMAGNA"
     gene            complement(5376..5585)
                     /locus_tag="H1Q60_RS15350"
                     /old_locus_tag="H1Q60_15350"
     CDS             complement(5376..5585)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017417420.1"
                     /locus_tag="H1Q60_RS15350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15350"
                     /product="aspartyl-phosphate phosphatase Spo0E family
                     protein"
                     /protein_id="WP_025649564.1"
                     /transl_table=11
                     /translation="MNKIEEKRLTLFETAQKFGINATETIRCSQELDSLLNGCRGGLIQ
                     QTKDSGPNPAAQIQHGREKKEAFS"
     misc_feature    5664..5684
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: medium, score: 26.99"
                     /tool="antismash"
     gene            5801..6706
                     /locus_tag="H1Q60_RS15355"
                     /old_locus_tag="H1Q60_15355"
     CDS             5801..6706
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388956.1"
                     /locus_tag="H1Q60_RS15355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15355"
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="WP_017417421.1"
                     /transl_table=11
                     /translation="MKFATGELNSRKFVGLIIDDDKILDLQKAEKKLFELETIPGSLIE
                     CIQKGDKFVAHAGQLAEWAKKPNDESGSFMYALSDVKLCAPIPRPSKNVICIGKNYRDH
                     AVEMGSEADIPEHPMVFTKAPAAVTGHGETVDSHLDVTEQLDYEGELAVIISKSGSHIS
                     KEHALDHIFGYTIVNDITARDLQKKHKQFFIGKSLDTTCPMGPVIVHKSAVSDPQSLKV
                     ETRVNGELRQSGSTGDMIFPIAELIETLSKGMTLEAGDIIATGTPSGVGKGFKPPKFLK
                     PGDRIDITIEPIGTLSNQIG"
     gene            6800..7156
                     /locus_tag="H1Q60_RS15360"
                     /old_locus_tag="H1Q60_15360"
     CDS             6800..7156
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388957.1"
                     /locus_tag="H1Q60_RS15360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15360"
                     /product="YisL family protein"
                     /protein_id="WP_003155128.1"
                     /transl_table=11
                     /translation="MTHWHITSWVVALILVFVSYGLYGAGKAKGAKITHMILRLFYIII
                     ILTGAELFVRFANWNGEYAGKMLLGIITIGLMEMLVIRKKKGKSTGGLWIGFIIVLVLT
                     VLLGLHLPIGFHVF"
     gene            complement(7356..7898)
                     /locus_tag="H1Q60_RS15365"
                     /old_locus_tag="H1Q60_15365"
     CDS             complement(7356..7898)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014417377.1"
                     /locus_tag="H1Q60_RS15365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15365"
                     /product="DUF2777 family protein"
                     /protein_id="WP_038456447.1"
                     /transl_table=11
                     /translation="MKRKQLFSEKNKWGRGTLMIEDGICLVENDEGDILLADSLGNADV
                     LMKRGGRWQPARICGGAAEIGADTIPLLGGEEIRYEKAVKRPLLTLLDSLDDETFLLFL
                     SHLHGFGLSVYDCVFSYNQALFSGEGVSFYHFSADDAQCALQHHRGSSGKHDRFEWTAS
                     DGRRSIMYSAARQDGTA"
     gene            8074..9915
                     /gene="asnB"
                     /locus_tag="H1Q60_RS15370"
                     /old_locus_tag="H1Q60_15370"
     CDS             8074..9915
                     /EC_number="6.3.5.4"
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="asnB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016938277.1"
                     /locus_tag="H1Q60_RS15370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15370"
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="WP_025649567.1"
                     /sec_met_domain="GATase_7 (E-value: 8.5e-48, bitscore:
                     159.3, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 1.2e-99, bitscore:
                     332.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIAGWVDFQKQLVQEKHIMNNMIDTLSKRGPDDSNVWGEPHVL
                     FGHKRLSVVDIEGGRQPMACTHQEETYTIIYNGELYNTEELRKELQARGHRFERTSDTE
                     VLLHSYIEWREECVDRLNGIFAFAIWDEKRERLFGARDRLGVKPFFYKEHGSSFLFGSE
                     LKAILAHPDVKARTDSGGLAEVFGLGPSRTPGCGVFKGIHEVRPAHAFTFSKDGLSIWR
                     YWNVKSEKHTDSFDETAAHIRYLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAIAAAHF
                     EKQGRDPLHTYSIDYEENSKFFKASAFQPNDDGPWIDKMTNAFGTQHHKCVITQDQLVE
                     HLEESVLVRDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFHTAAEEDG
                     FPWMRSTEERITLLDEKWQKRLNLREYVNARYEETIAETPLLDGETGTDKARRQLFYLN
                     MLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHGSREKGILRKALE
                     GLLPEDILYRKKSPYPKTHHPKYTQGVTEWLKTILQQKDSVLHTLLDRKKLEMLLETEG
                     SSFQVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIEE"
     gene            10001..10741
                     /locus_tag="H1Q60_RS15375"
                     /old_locus_tag="H1Q60_15375"
     CDS             10001..10741
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014417379.1"
                     /locus_tag="H1Q60_RS15375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15375"
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_017417423.1"
                     /sec_met_domain="phytoene_synt (E-value: 8.5e-24, bitscore:
                     82.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2e-30,
                     bitscore: 104.0, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEYETCAQLAEAHFPLYKRTFSSLPPKNRRAAWAVLALFHEADR
                     LDVQELGGFEQAAQDFLNGTHADGFLWEALADVRQQFALEEEPLREFIAGQISDREKVT
                     YQEFDDLLMYAGQTGGALGLLLLPVCARRNQEKLRHAAVSLGAAIQLTRVLLGVHTDER
                     AKKRLPRQVMKQFGYTEEELESHTVNKAFMNVWEYIAFEAEAYFEEASEELELFPLYSR
                     PAVTGLLAHYRSELGDMRKQLSQA"
     gene            complement(10777..12144)
                     /locus_tag="H1Q60_RS15380"
                     /old_locus_tag="H1Q60_15380"
     CDS             complement(10777..12144)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /function="Na+-driven multidrug efflux pump"
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388962.1"
                     /locus_tag="H1Q60_RS15380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15380"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_022553576.1"
                     /transl_table=11
                     /translation="MKQAILKRAAFKQSSDHKLSLYALTWPIFIEVSLYMFMGNADTLM
                     LSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTIVISQFLGSKQKKEAQEVAYVSIGA
                     NFVISLAISAAIFFAAVPLLHVMGLSNELMPDAKVFLQVVGGLSFIQALIMTFSAILKS
                     YGHTKDTMFVTIGMNILNIAGNFLVIFGPLGLPVLGVAGVAMSTSFARIIGLIAMVVIV
                     KKRIGLGLTWQKIFHVHKEHLRKLLKIGIPSAGEQLSYNISQMVVTYFIAIMGAQALTT
                     KVYTQNITMFILLFGTAISQGTQILIGRYIGAKRFDDAYDRCMKSLYWALGIAALTSVI
                     MTLFSKQLIGIFTSSPDIIATASMLIAMTIILEPGRSFNVIIINSLRAAGDAKFPVYMA
                     MISMWGIGLPLAYLFGIHFGLGLMGIWISFIADEWVRGILMYRRWRSRIWIQKGIA"
     misc_feature    12197..12210
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.16"
                     /tool="antismash"
     gene            12267..13130
                     /locus_tag="H1Q60_RS15385"
                     /old_locus_tag="H1Q60_15385"
     CDS             12267..13130
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017417425.1"
                     /locus_tag="H1Q60_RS15385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15385"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_104843243.1"
                     /transl_table=11
                     /translation="MSFLEFTVPPFPVFIAAGEGVFKKGETHVRRVFPVFDLLYVKKGV
                     LYITEDENAFSVEAGEYILLSPGLEHYGTKGSEETTSYSWLHFEGADYEVTETTGNNWS
                     ELRRKKGSFEEPSRYRLSLPQKGKVRRPQFMAGQFSVLTDDSAENSDLPLRKQILFEEL
                     LLHLQKEAFQIPSAKERVAWEAARYLQGHYQEKTTIKALSSALHYNQDYVTRCMQQVLG
                     VTPGQYTNKVRMTEAKRLLSATNDKMGAIADAIGMEDPTYFSKLFKQIEGISPLEYRKF
                     VSRKTD"
     gene            13166..14191
                     /locus_tag="H1Q60_RS15390"
                     /old_locus_tag="H1Q60_15390"
     CDS             13166..14191
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017417426.1"
                     /locus_tag="H1Q60_RS15390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15390"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_025649569.1"
                     /transl_table=11
                     /translation="MKMTIYDVAEKAGVSISTVSRVINNTGRISVKTRRMVLRVMEEMD
                     YHPNVHASALTGKKTNMIGLITPDISNPFFGELAKSIEDSAGVLGFHIIICSTDYQPEK
                     ETKYFSMLRQKQADGIIFATGLDHDDSVTALDDIVKSGIPLAMITQDKPLAPMDVVIID
                     DFLGGYTAAEHLISLGHERIACIVGNGSTTGERDRIKGFQKAMREAGMTLDESLIIPTE
                     YSLESGKQAAGELFDRDLPTAVFAFNDVLSCAAIQAARSRGIRVPEDLSVIGFDNTILA
                     EMTAPPLTTISQPIREMGRRVVELLIDEIQGKKKTKSKIILSPELVIRHSTAPVKTRPQ
                     Q"
     misc_feature    14208..14222
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.27"
                     /tool="antismash"
     misc_feature    14238..14254
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.44"
                     /tool="antismash"
     gene            14417..15448
                     /gene="iolG"
                     /locus_tag="H1Q60_RS15395"
                     /old_locus_tag="H1Q60_15395"
     CDS             14417..15448
                     /EC_number="1.1.1.18"
                     /GO_function="GO:0050112 - inositol 2-dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019310 - inositol catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="iolG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017417427.1"
                     /locus_tag="H1Q60_RS15395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15395"
                     /product="inositol 2-dehydrogenase"
                     /protein_id="WP_106067876.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 3.2e-34, bitscore:
                     116.1, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.4e-26,
                     bitscore: 90.8, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDQVRCAVLGLGRLGYFHAKHLAGEVRGAELAAVCDPMKGKAEA
                     CAKELGIAKWTENPYDLLEDHTIDAVIIVTPTSTHAEMIMKAAENGKHIFVEKPLTLSL
                     EESKEVMKKIEETGVICQVGFMRRFDPAYADAKRRIDAGEIGRPIYYKGFTRDQGAPPA
                     EFIKHSGGLFIDCSIHDYDIARYLMNAEVTSVCGHGRILKHPFMEKCGDVDQALTYLEF
                     DSGAAGDVEASRNSPYGHDIRAEIIGTAGSILVGTLRKSHVTILTESGSSYEIIPDFQA
                     RFKDAYRLELEHFAECVKKGETPIVTDVDATINLEIGIAATESFKTGRPVKLTPGAFGY
                     AGL"
     gene            complement(15494..15988)
                     /locus_tag="H1Q60_RS15400"
                     /old_locus_tag="H1Q60_15400"
     CDS             complement(15494..15988)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1250: DinB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015239546.1"
                     /locus_tag="H1Q60_RS15400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15400"
                     /product="DinB family protein"
                     /protein_id="WP_072177111.1"
                     /transl_table=11
                     /translation="MSDILKLYHYHRWANEQVIQHLKTLPAASLQQKLDSVFPTVNAVL
                     VHIYRADYIWLHVLYGETYEQIVSQFDQFEKLDGDFEAIEHRMAELDKEYSKFLRELEN
                     TEGPISISHPRMGTLRTTYADVIRHVVNHGTYHRGNISAMLHQMGYKSVPTDYIFFSYE
                     S"
     gene            complement(16043..16651)
                     /locus_tag="H1Q60_RS15405"
                     /old_locus_tag="H1Q60_15405"
     CDS             complement(16043..16651)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014417385.1"
                     /locus_tag="H1Q60_RS15405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15405"
                     /product="LysE/ArgO family amino acid transporter"
                     /protein_id="WP_106067875.1"
                     /transl_table=11
                     /translation="MNAILHGVMLAFGLILPLGAQNVFIFQQGAWQKHVWQAFPAVIAA
                     AVCDTILIIAAVAGVSMIIAEIPVFQTVMLIGGFLFLSFLGWQTWRSKPQAEQAKKTVF
                     SAKKQAVTAAMVSLLNPHAILDTVSVIGTSSAAYPGIDKWLFASACIAVSWVWFAGLAF
                     AGRLVQTADTGGRLLDILNKCSALVMWGAAFYFAALLFR"
     misc_feature    16611..16626
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.61"
                     /tool="antismash"
     gene            16777..18219
                     /locus_tag="H1Q60_RS15410"
                     /old_locus_tag="H1Q60_15410"
     CDS             16777..18219
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (119-458). E-value:
                     6.3e-34. Score: 109.6. Matches aSDomain:
                     nrpspksdomains_H1Q60_RS15410_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014417386.1"
                     /locus_tag="H1Q60_RS15410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15410"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_025649571.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4e-32, bitscore:
                     109.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSWRPDRESYIPLYLQIEQHIKEKILHGEWTIGTKIPSQRKLAE
                     ELQVNRSTVTAAVDELIAQGLLEGKRGGGTKVVNSTWSIMAAAKPLDWSTYVTSGSHQP
                     NSALVQAINQNEPRPDLIRLGTGELSQELLPEKEMAELFREAGTNIFALGYEEPKGSLK
                     LRQSVAEYVKTKGIHASPASIVIVSGALQALQLISIGLLKPNSVMLTENPSYLHSLRVF
                     QSAGVRLKGVPMDESGIKTDHLPAYRRQYEAGLLYTIPSFHNPTGTVMSLKRRKELIAL
                     ARNHRLPVIEDDAYGDIWIDKEPPPPLKSMDGEGNVLYIGTLSKTVSPGLRIGWVVAPE
                     PVADRLADIKMQTDYGSSALSQWAACQWLSSGRYEERLLRLRKELKIRRDAALRFLERY
                     AEDIAEWRVPEGGFYIWVTFHQTIAVQKLFTRALEAGVLINPGALYLPEDRQSLRLSYS
                     YASLPGLEKGIQTIADIARRFV"
     aSDomain        17134..18150
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_H1Q60_RS15410_Aminotran_1_2.1"
                     /evalue="6.30E-34"
                     /label="H1Q60_RS15410_Aminotran_1_2.1"
                     /locus_tag="H1Q60_RS15410"
                     /protein_end="458"
                     /protein_start="119"
                     /score="109.6"
                     /tool="antismash"
                     /translation="DLIRLGTGELSQELLPEKEMAELFREAGTNIFALGYEEPKGSLKL
                     RQSVAEYVKTKGIHASPASIVIVSGALQALQLISIGLLKPNSVMLTENPSYLHSLRVFQ
                     SAGVRLKGVPMDESGIKTDHLPAYRRQYEAGLLYTIPSFHNPTGTVMSLKRRKELIALA
                     RNHRLPVIEDDAYGDIWIDKEPPPPLKSMDGEGNVLYIGTLSKTVSPGLRIGWVVAPEP
                     VADRLADIKMQTDYGSSALSQWAACQWLSSGRYEERLLRLRKELKIRRDAALRFLERYA
                     EDIAEWRVPEGGFYIWVTFHQTIAVQKLFTRALEAGVLINPGALYLPEDRQSLRLSYS"
     gene            complement(18228..18854)
                     /locus_tag="H1Q60_RS15415"
                     /old_locus_tag="H1Q60_15415"
     CDS             complement(18228..18854)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003155116.1"
                     /locus_tag="H1Q60_RS15415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15415"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_017417429.1"
                     /transl_table=11
                     /translation="MNTIQKPKIPKELPVLSFTEALQDDLIKEVVIENAVISGKLDGLR
                     AEKVIFRNTVFTDVSFRHMECTDVLFDKCDVSNADFSGSIIHRTAFQHSKLLGLNLADS
                     AMRHVRFEDCLAHYSSFSYSNMKHVRFDTCGLSESEWNDAVLEYTDLDVCDLNGANFIG
                     TSLFNMDISTCTFDHLHVSLEKLKGCRISPSHAVTFAEALGAIVT"
     gene            complement(19079..19519)
                     /locus_tag="H1Q60_RS15420"
                     /old_locus_tag="H1Q60_15420"
     CDS             complement(19079..19519)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012117261.1"
                     /locus_tag="H1Q60_RS15420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H1Q60_15420"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_007409151.1"
                     /transl_table=11
                     /translation="MVEVKPITAEDTYAIRHSVLRPHQTIEDCKYDQDSVKGAFHLGGF
                     YDGTLISIASFYPQNQQALQAAPAYQLRGMATLEEYRTQKAGSTLIAYAERKLADMGAA
                     LVWCNARCHVKGYYEKLGWKSTGSPFDIPGIGPHVIMYKELA"
ORIGIN
        1 gcgcctgttt aatctggaac agtacgggga caggcttgtc aaaaaattgc ggaggcgggc
       61 gcaggaagcg gcagcgaaaa aaaatgaaat gctggccgaa caatccggcc tcggagacgc
      121 aggagaagat gcgctgaagc aggctgaaca gcagtttcac gaagcgaacg aacggcttga
      181 agaagcggag aagaaacggg tccgggcaaa agagcgtttt gaaagtcacc aggaaatttg
      241 gaacctgcag acagaaagag atgaatatga gcgccgggag aaaaagcttg aggaaagacg
      301 cccgtacatc acggatttga ctgagcgtct taaagaggcg gaaaccgctc tcgcccttga
      361 gccgtacgca gaccgttaca cagaagccgt ccgccggaag cagcgcgccg aacaggagca
      421 cgaactggcc aaacggaaat cagaggcgga aaccgtttca tttacccggc aaaatgaagc
      481 ctatgaagca tggcgggccc ataaggccga acaggagccg aagcttgtca aggaagaaga
      541 gctgtatcaa agactttcag ccatagaaca aaaactgctt gaagcgaaaa aagaagcgga
      601 aaaaacaaat gcggaacaca gcaaaaaaga ggaagaatac gaagccgcct cgaaacagct
      661 ggccggagtg aaagaccgcc tgacccgcgg taaaaacagg cagaatgagc tgaaagaaga
      721 gctgaaagca gttcaagtga ccgccaatga acggaaaaaa tgccagaccg cagcacagct
      781 ggcggcgggc tttcagcaga cacaggaaca aatcacgaaa gaacgggcca atctgacaac
      841 gcagctgaaa aacatggaga agctgaacgg agaaagcgag tcgctcacag cgaaagcgaa
      901 aatcgaagag gaagacatta cgcacgctta tcaaacgctt caaaccgttt accatatggt
      961 ctgtgaaacg gagcgttcac tgaaagccgc agccgaacgg gctgacaaaa cgcaagccga
     1021 tctccgcagg cgctcagagg aagcgagaac ggctgcatta acaaaagaat tatcggaaaa
     1081 actaatcgaa ggaaagcctt gtcctgtatg cggctcgacg cagcatgacc gcccgcgttc
     1141 cgctcatgaa acattctcgc ctgatacggt tgtacaggaa cagttgcagc aggttgaagc
     1201 gctgctttct gaggcggcgg ctctttctca ggaagtgctg acagccaagg ttgcattaga
     1261 agagcagtcg gggcgtttta ccgaagaatg tccgtttctg caaagcgccc gggttccgga
     1321 gctggaagcc gcttcttcca tcagcggacg cccgcttgat gaagcgttca gcgccgtccg
     1381 cttggaatgg aaacaaatga aacaggatat gctgtcggta aaagagaagg tcacaagact
     1441 gatcagcgcg catcagcaga cggtgaaaca agctgagcag cttgccgaac gaatccgcta
     1501 cgaggaaaaa gaagccgacc gtctcagaca ttcattagaa gagcttgaat cgctgtcaga
     1561 aagccgattg aatcagtaca acgaagtctg cggtgatatt ccgccaaacc ggattgacgc
     1621 ctggcaggct tcgatagatg agaaggacag gcaggcagaa gaatgtgaga agcgcattga
     1681 aacaagcatc gcattcctca aggaacatga agaggagaaa gaacgcctgc aggagatgaa
     1741 gcatcggctt gaacgggaac ggctcgagct tcactatgcg tctgagcgcc tgcagcaggt
     1801 gattgacgga tatgaacaag agctcggaac agcagctgaa gaaacatcaa tttccgcaaa
     1861 gcttgaagcg gtgcggcagg aattacagct gttaaaatcg aaagagcagt ccctattcga
     1921 tgcgctgaag caggcgcagc aatcactgaa tgacgcaaaa ggccgggaat ccgggagtct
     1981 catgtcactc agggatgctg agacctccct tgagaaagcg caaaacgact ggcgcttgag
     2041 gtcaaaagac accggattta ccgagccgga ccaagtcaaa aaaagtctgc ttccgcaagg
     2101 gcgtgcagag gaaatgaaaa aagaaattga tgagttcctg gacacctcaa aacagctatc
     2161 ggcaaatatc agccgtgtta ctgataaatt agccgaccgc cggatatcag aggaagaatg
     2221 gacagtatcc gtttctctgc tgaagcaggc agaggctgag tcaggcgccg ccatggagga
     2281 aaaaggagca caggcaaaag ccttcgcggt tatgcaaaaa cagcataagc gctttaaaga
     2341 gattgaagcc gaactgaaaa gctggcagac acagattgac aggcttgata agctccagtc
     2401 tgtatgtaaa ggcaatacat tcgtcgaatt tttagcggaa gaacagctgg aaagcgtggc
     2461 tcgggacgcc tctgcccgtc tcggagcgct gacaaggcag cggtatggca tattagtcga
     2521 ttcagaaggc ggtttcgtca tgcgtgatga cgcgaatgga ggcgtcaaac ggcccgtatc
     2581 aagcctttcc ggcggggaga cgtttctgac atcgctgtcg cttgcgcttg ccttgtccgc
     2641 ccagattcag ctgcgggggc aatacccgct gcaattcttt ttcttagatg aaggattcgg
     2701 gactcttgac caagggctct tagacaccgt tgtcacagcg ctcgaaaagc tgcaatcgga
     2761 caacttatcc gtcggagtga tcagccatgt gcaggagctg agagcgcgtc tgccgaaaaa
     2821 attaatcgtt catccgtccg aaccgggcgg gaaaggcacc cgggtcacat tggagatcat
     2881 gtagaaagga gaaggaatta tggccgattc tgccgagggc acatgtgaat tatgcggccg
     2941 ccatcatgtg cggctgacgg agcaccactt aacgcctaag gaagaaggcg ggacattcct
     3001 tccgaccgca atgctctgca tcccttgtca taaacaggtt cacgcgctct atacgaatca
     3061 ggagcttgcg gcaaggctcg cgggaataga agagctgcgg cgtgacccga aactcgcgcg
     3121 gtttgtgaaa tggatcagaa aacagccgcc aaaaaagctt gtaaaaacaa aaaaagcaaa
     3181 tgaacgaaca taacgctgaa ccaaaagcag ccctcttctg aaagagcggc tgctttttag
     3241 gcgtttccga ccacattttg atcgctgaca tcggggtcta tatagtttgt cgcattgaca
     3301 acgttgttta ataacaggaa atctccggta ttgcctgctc ccgaaccgag cgcagattta
     3361 gaagagcttt ttggagaaag gtaaaaggaa tcaccaaagt ttacgactcc gcccgatatg
     3421 gaattgatag ctataggtcc ggtaattgct ggcataaacg acacccttta tagaagtctc
     3481 accgtcatta tatgtcaggg ctgctgtgat tgtgagcttg atgtgaagat ctgcctaata
     3541 tgtttcagcc gcgaatctcc cagaacgatc gacgtcgatc cgatttgaac cacggacgct
     3601 gacgataccc cttgaacttt cacattcctt acccgaattg aagggttttc atggcagaat
     3661 gcgctttgga ctcccgtttc cggtaacggc atgacggccg gctgccgaaa gatctggtat
     3721 tcttttttgt taaatgagcc ttcatcatct ctgtatacag caagactacg ctgatcggcc
     3781 aatactttga cccgcatatt gatttcattc gtatcgcctg cttgaaagac actcgcaatc
     3841 ccgactgaat tgattttggc gttccggagg cgtgaaatgc gctttaacat tattccggcg
     3901 ccagcggcac ataagggccg ataataagag attccggagg cgtgtcaaag atggaagaca
     3961 gatagacgga atcggtgtcg ccgattaata ataaggaaga actggataca ccggtagacc
     4021 ggatgtcgcc gacttcaata ttccggttaa tcactgtaaa aatcatgacg gatcatcacc
     4081 tttcatttca ccaggtatgt gcttaataaa gtgctcgacg gccctgacaa tatcacgctt
     4141 cacatgttcg gcaatctgct cggcatattg cgcgggcgcc gtattttctt ctttcgggac
     4201 atgggacaga taatacttaa tccggctgtc catctgcttt ctgatatctt caataatatg
     4261 atatttgttc gcttcgtcca gcctgctctc atactgagtt tcgagcttct ctaaaagcgc
     4321 ggggatttct tcattcaggt acatatcgac gttttggcgg atttgctgca tttgctggcc
     4381 cgcctgttcc tgctgcatca ttccgacctg cggagatgtc tggccgactt cgaagttttg
     4441 cacggcattc ggatcagtcg gattcaatcc gatattcagc gttccttcca gccgttcaat
     4501 tttcagctga tcaaatttat actcgagccg atcgattctt gtagaaggct gctgcttcag
     4561 cgttgaaatt tcattttgga attctttcag ctgccgttcg agctcctgaa tctgctgcgc
     4621 ctgctgctgg acgaaagaat ttaaattctg caggtaggat gaaacggatt gatcatacat
     4681 gacattcacc tcgcgtctcg tttccttcat taaaactacc ggcttggcgg ctggagcggt
     4741 acaaatgatg aggtgccggg acctccccct gttgttacag tctgctgccc tgcagtgaca
     4801 ggcggcgccg gctcaacata actccctgta ttgtacagat tggaaagaga tttaattgaa
     4861 ccggcgcttc cgatttgcag tatggaggaa ttgctgacag attctacacg catgtaattg
     4921 atatggatcg actgattgac gtaaaaattc atacggcgcc tcctttatgc gtttcctgcc
     4981 atcggctgat cgattacatc attatcgtac acattcgttg aattcctgta attcgtcagt
     5041 gtgagattgt ctccggtatt gaagctgccc gctccggcaa atgtcttaac ctctgctttt
     5101 ggagaaatgg tgatgcagtc gcctatatga acgactccgc tcgtaccgac ggcattaatt
     5161 ttaaacgctc cgacaattgc gggcatacga gcacatcctt ttcgtgaaga ttttcatgac
     5221 tatactccag gagcttatct gggctgcctg cctaaaatag cttatgacaa atgcacattt
     5281 ttgtgagcgg aaaaaacttt agacgtaaaa acaccggcgc tatacgcatg ccgggcctta
     5341 tacataaatg atacagattt atatacacat cacgtttatg agaaagcctc ttttttttcg
     5401 cggccgtgct gaatctgtgc ggccgggttc ggcccgctgt ctttcgtttg ttggatgagc
     5461 ccgccccggc acccgtttaa aaggctgtcc agctcctggc tgcacctgat ggtctccgtc
     5521 gcattgattc cgaatttttg cgctgtctcg aataaagtta atcttttttc ttcaattttg
     5581 ttcatcgtgt gatctccaat tctcgattat tttggaaaac ataggatgat aatagtataa
     5641 cccattttgg ccaagaaggt tttatttcgt caatatgact aaaaaagtga caatttttga
     5701 tactctttta cacttatttt cagcctgttt aaaagaggga tttcccgttc ggaggaagaa
     5761 tacataaagg aatgccattt aaaaatgatg ggggattaac atgaaatttg cgacagggga
     5821 actgaacagc cgaaaatttg tcggtctgat tattgatgat gacaaaatct tagatctgca
     5881 aaaggctgaa aaaaaattgt ttgaacttga gacgattccg ggttcgctga tcgagtgcat
     5941 tcaaaaagga gataagtttg tcgcgcatgc cggacagctt gcggaatggg cgaaaaaacc
     6001 gaatgacgaa tcaggttcat ttatgtatgc gctgtctgac gtaaagcttt gcgcgcctat
     6061 tccgagacct tcaaagaacg tgatctgcat cgggaaaaat tatcgtgatc atgccgttga
     6121 aatggggagt gaggcggata tacccgagca tcccatggtt ttcacgaaag ccccggctgc
     6181 cgttacagga cacggagaaa cagtggacag ccacttggat gtaacggagc agcttgatta
     6241 tgaaggggag cttgcggtaa tcatatcaaa aagcggatcg cacatctcca aagaacatgc
     6301 gcttgatcat atattcggct atacaattgt aaatgatatc acagcgcgcg atctgcagaa
     6361 aaaacataaa cagtttttta tcggcaaaag cctggatacg acatgcccga tgggcccggt
     6421 cattgtacat aagtcggccg tcagcgatcc gcaaagcctg aaagttgaaa cgcgggtgaa
     6481 cggtgaactg cgccaatcag gatcaacggg tgacatgata tttccgatag ctgaattaat
     6541 cgagacgctg tcaaaaggaa tgacgcttga agccggtgac attatagcga cggggacgcc
     6601 gtccggtgtc ggaaaaggat ttaagccccc gaaattttta aagccggggg accgtattga
     6661 cattacaatt gaaccgatcg gcacactgtc gaaccaaatc ggataattgt gtgtctttcg
     6721 cacgattgat aatgctccga gaggcttgtt gtggtaccat aagtgaggca gattgatctg
     6781 atagggggga ttgaacataa tgacacattg gcatattact tcatgggtcg ttgcgcttat
     6841 cctggtgttt gtcagctacg ggctgtacgg tgccggaaaa gcgaagggcg caaaaattac
     6901 gcatatgatt ctgcgcttat tctacattat tattattctg accggagctg agctttttgt
     6961 ccgttttgcg aattggaacg gagagtacgc cggaaaaatg ctgctcggca tcattaccat
     7021 cggactgatg gaaatgctcg tcatccgtaa gaaaaaaggc aaatcaaccg gcggactgtg
     7081 gatcggtttt attatcgtgc tcgtcctgac ggtgctgctc ggccttcact tgccgatcgg
     7141 ctttcacgta ttttaatcaa tcgcttgaaa aacccggatg tatccgggtt tttttagttg
     7201 cgcatacatt ttgcgcaact gtgccagcgt caatcactct cgttaccgca aaagctacgg
     7261 ctgtaaaggg taaaagcaaa cgccgggcgt caatcagcgt gaaaacaaag ctaaatccat
     7321 caggcggcac ctatttaaaa ggtgccgcct gtttgttacg cggtgccgtc ttgtcttgcc
     7381 gctgaataca taatggagcg ccgcccgtca gatgccgtcc attcaaatct gtcgtgttta
     7441 cccgagctgc cgcggtgatg ctgcagggcg cattgtgcgt catccgccga gaagtgataa
     7501 aacgaaacgc cttcaccgga aaacagcgcc tgattgtagg aaaatacgca atcatataca
     7561 gacaggccga acccgtgcag atggctgaga aacagcagaa acgtttcatc gtccagcgaa
     7621 tcgagcaagg ttaacagcgg ccgtttgacc gccttttcat aacggatttc ttccccgccg
     7681 agcaggggga tggtgtctgc gccgatttcg gccgcaccgc cgcaaatccg tgccggctgc
     7741 catcggccgc cgcgtttcat caatacgtct gcgtttccta gactgtctgc aagcaggata
     7801 tcgccttcat cgttttcgac gaggcagatg ccgtcctcta tcatcagggt gccgcgcccc
     7861 catttgtttt tttctgagaa aagctgtttt cgtttcataa ccgtgccggt ctcctttgtt
     7921 tgtttcttct cttccgttct ttccaaatcg ggcttgtctc atacaagtct tagtgggaca
     7981 aatcaactat ctgagtttct ttgcataaac tgggtaaagt gctgatagaa acgaatttga
     8041 aaccgacaga aacgggattg gagctgatat cacatgtgtg gaattgcggg ttgggtcgat
     8101 tttcaaaagc agctcgtcca agagaaacat attatgaaca atatgataga cactctttca
     8161 aaacgagggc ctgatgattc aaacgtctgg ggagagcccc atgttttatt cggacataaa
     8221 agactttcgg tcgttgacat tgaaggcggc cgccagccga tggcctgcac gcatcaagag
     8281 gaaacgtaca cgatcattta taatggcgag ctgtataaca cggaggaatt gcggaaggag
     8341 cttcaggcga ggggccaccg ttttgagagg acctctgata cagaagtgct gctgcacagc
     8401 tatattgagt ggcgggagga gtgcgtggac cgcttgaacg gtattttcgc ttttgccatc
     8461 tgggatgaaa agcgcgagcg gctgttcggg gcaagagacc ggctcggcgt caaaccgttt
     8521 ttttataaag aacacggctc ttcctttctg tttgggtcgg aattgaaagc catccttgct
     8581 catcctgatg tgaaagcccg cacagacagc ggcggacttg cggaagtatt cggactcggg
     8641 ccgtccagaa ctccgggctg cggggtgttt aaaggaattc acgaggtgcg tcccgcccat
     8701 gcgttcactt tctcaaagga cggtttgtcc atatggcgtt attggaatgt aaagagcgaa
     8761 aagcatacag acagcttcga tgaaaccgcg gctcacattc ggtacttatt tcaggatgca
     8821 gtgacacgcc agctcgtatc tgacgtgccg gtttgcacgt ttttatcagg ggggcttgat
     8881 tcgagcgcga taaccgcgat agccgccgct cattttgaga aacaaggcag agatcccctt
     8941 catacttatt caattgatta tgaggagaac agcaaatttt ttaaagcgag cgcgtttcag
     9001 ccgaatgatg acggcccgtg gatcgataaa atgacaaatg cattcggcac acagcatcat
     9061 aagtgcgtga ttacgcagga tcagctggtt gaacatctgg aggaatccgt tctcgtcaga
     9121 gacctgccgg gcatggctga tgttgattcc tcgctattat ggttctgccg ggaaattaaa
     9181 aaagattttg tcgtgagcct ttccggagaa tgtgcggacg aaattttcgg cggatatccg
     9241 tggtttcaca ccgcggcaga agaagacgga tttccttgga tgaggtcgac tgaggagagg
     9301 atcacgctct tggatgaaaa gtggcaaaaa cggctgaacc ttagagaata cgtgaatgcg
     9361 agatatgaag aaaccattgc ggaaacgccg ctgttagacg gtgagacggg aacagataaa
     9421 gcgagacggc agctgttcta cttaaatatg ctttggttta tgacaaatct gctcgaccgc
     9481 aaagaccgca tgagcatggg cgcaagtctt gaagtacggg tgccgttcgc cgaccacaga
     9541 cttgtggaat acgtttggaa tattccttgg gaaatgaaaa tgcatggcag ccgggaaaaa
     9601 ggcatcttgc ggaaagcgct tgaaggactg cttcctgaag atattttgta ccgcaaaaaa
     9661 agcccttatc cgaaaacgca tcacccgaaa tacacgcagg gggtcacaga atggctgaaa
     9721 acgattttac aacagaaaga ttccgtgctt cacaccctgc ttgacagaaa gaagctggaa
     9781 atgctgctgg agacagaagg ttcatctttt caggttccgt ggttcggcca gctgatgaaa
     9841 ggcccgcagc tgatcgccca tcttgcccag atccatacat ggtttgaggc gtaccgtatc
     9901 gatatagaag aataacagtg ccgcgaccgg tttccgctga aggatatcgg tctttttatt
     9961 gtgaaacata tggtacacta aaaaacagag gagtgatacc atgaccgaat acgaaacatg
    10021 cgcccagctt gccgaggcgc actttccttt atataaacgg actttctcat ccctgccgcc
    10081 aaaaaacagg cgggccgcat gggcggtgct tgctttgttt cacgaagctg accggcttga
    10141 tgtgcaggaa cttgggggat ttgaacaggc ggcacaagac tttctgaacg ggacacacgc
    10201 tgacggcttt ttgtgggagg cgctcgccga tgtgcggcag caatttgcgc ttgaagaaga
    10261 gccgttacgt gagtttatcg ccggccaaat ctctgacaga gaaaaagtaa cgtatcaaga
    10321 gtttgatgac ctgctgatgt acgcgggcca aacaggcgga gccctcggcc tgcttctgct
    10381 gccggtttgc gcgcgccgga accaagagaa actccgccat gcagccgttt cattaggggc
    10441 agccattcag ctgacccggg tgcttctggg ggtccatacg gatgagcggg cgaaaaagcg
    10501 tctcccgcgc caggtgatga agcaattcgg ctatacggaa gaagagctgg agagccatac
    10561 cgtcaacaaa gcttttatga atgtatggga gtacatcgca ttcgaggccg aggcgtattt
    10621 cgaggaggcg tctgaagagc tggagctgtt tccgttatac tcaaggcccg ccgttaccgg
    10681 tttgctggca cattaccggt cagagctcgg tgacatgaga aaacagcttt cgcaagcata
    10741 aaaaaacgcc cggcttcata acgaagcttc gggcgtttat gcaatccctt tttgaatcca
    10801 aatccgcgac cgccatcttc tgtacataag aatgcctctg acccattcat ccgcgataaa
    10861 tgaaatccag atgcccataa gccccaatcc gaaatggatg ccgaacagat aagcgagagg
    10921 cagtccgata ccccacatgg aaatcatcgc catgtaaacg gggaattttg catctccggc
    10981 agcccgcagc gagttgataa taatgacatt aaatgaacgg ccgggctcaa gaatgatcgt
    11041 catggcgatc agcatgctcg ccgtcgcaat aatgtcaggg ctgcttgtga aaattccgat
    11101 cagctgcttt gaaaacaagg tcatgatcac ggatgtcaaa gcggcaatgc caagcgccca
    11161 gtacagactt ttcatgcagc ggtcataagc gtcgtcaaac cgtttggcgc cgatatatct
    11221 gccgatcaaa atctgtgtgc cctggctgat cgccgttccg aacagcagga taaacatggt
    11281 gatgttttgc gtataaacct ttgttgtaag cgcctgagcg cccataatgg cgataaaata
    11341 agtgacaacc atttgtgaaa tgttgtaaga cagctgttcg ccggcagacg gaatcccgat
    11401 tttcaggagt ttccgcaagt gctctttatg gacgtgaaaa atcttttgcc atgtcagacc
    11461 gagtccgatg cgttttttga cgatcacaac catcgcgatc agtccgatga tccgcgcaaa
    11521 ggacgttgac atcgcaacac cggcgacgcc taacaccgga aggccgagcg gcccgaaaat
    11581 gacaagaaag tttccggcaa tatttaaaat attcatcccg atcgtaacga acatcgtatc
    11641 cttcgtatga ccgtagcttt ttaaaatggc actgaatgtc ataatcaaag cctgaatgaa
    11701 ggacagcccg ccgaccacct gcaaaaagac tttggcatcc ggcatcaatt cattggaaag
    11761 acccatcaca tgaagcagcg gaacggccgc aaaaaatatg gcggcgctga tggcgagact
    11821 gatgacaaag ttcgctccta ttgatacata agccacttcc tgcgcctctt ttttctgttt
    11881 agatcctaaa aactgtgaaa tcacaattgt cgtacccgtt gcgataaagc tgaacatcac
    11941 gataattaaa tttaaaatct gattgctgac acccacggcc gccacactgt tgtcagagta
    12001 ttggctaagc ataagagtgt cggcgtttcc cataaacata tataatgaaa cctcaataaa
    12061 tatcggccaa gtcagcgcgt ataatgagag tttgtgatca gaggattgtt tgaacgcagc
    12121 ccgttttaaa atcgcttgtt tcatttcttt taaccccttt cctgacaaaa tcaacgttta
    12181 aaagtgtacc tccattttct tataataaaa agggagagaa acgaaacttc ttgcaaaaat
    12241 ccgacttaaa aaggagggcc gaaaatatgt cctttctcga gttcacagtt cctccgttcc
    12301 cggtctttat cgctgcggga gaaggagtgt tcaaaaaagg cgaaacccat gtgagacggg
    12361 tcttcccggt gtttgatctg ctgtatgtga aaaaaggcgt cctctacatt acagaagacg
    12421 aaaacgcctt ttccgttgaa gcgggagaat atattctgct ttctcccggc cttgaacatt
    12481 acggaacaaa aggcagtgaa gaaacgacat cttattcgtg gcttcatttt gaaggagcgg
    12541 attatgaggt gacggaaaca accgggaaca actggtcgga gctgaggcga aaaaaaggga
    12601 gctttgaaga gccgtcccgc taccggctgt ccctgccgca aaaagggaag gtgagacgcc
    12661 cgcagtttat ggccgggcaa ttcagtgtgc tgacagatga cagcgcagag aactccgatc
    12721 tgccgctcag aaagcagatt ctgtttgaag agctgctgct ccatcttcag aaagaagcgt
    12781 tccaaatccc gtccgcaaag gaaagagtcg catgggaggc cgcccggtac ctgcaggggc
    12841 actatcagga gaaaacaacc atcaaagcgc tctcttcggc tcttcattac aaccaagact
    12901 acgtgacccg ctgcatgcag caggtgctcg gcgtcacgcc cggccagtat acgaacaaag
    12961 tcagaatgac ggaggcgaaa cgtcttttgt ccgcaaccaa tgacaaaatg ggggcgatcg
    13021 cagacgccat cggcatggag gacccaacct atttttccaa actgtttaaa cagattgaag
    13081 gcatttcgcc gcttgaatac cgcaaattcg taagccggaa aacggactga cctaatacca
    13141 gagaacagaa gagggatcgg taagcatgaa aatgacaatt tacgacgtgg ccgaaaaagc
    13201 gggcgtctcc atctcgaccg tctcgcgggt catcaacaat acggggagga tcagtgtcaa
    13261 aacccgccgg atggtgctcc gtgtcatgga ggagatggac tatcatccga atgttcacgc
    13321 atccgctttg acgggcaaaa agacgaatat gatcggcctg atcaccccgg acatttcaaa
    13381 cccgtttttc ggggaactgg cgaaaagcat tgaagacagc gccggtgtac ttgggtttca
    13441 tatcattatc tgcagcaccg attatcagcc tgaaaaagaa acgaagtatt tttcgatgct
    13501 gcggcagaag caggcggacg gcattatatt cgcgacggga cttgatcatg atgacagcgt
    13561 cacggcgctt gatgatattg tgaaatcggg catcccgctt gcgatgatta cgcaggataa
    13621 accgctcgcg ccgatggacg tcgtcattat cgatgacttt ctcggcggct atacggcggc
    13681 tgagcatctc atatctttag gccatgaaag aatcgcctgt atcgtcggaa acggctcgac
    13741 cacgggtgaa agagacagaa tcaaaggttt tcaaaaagcg atgcgggaag cggggatgac
    13801 actagatgaa tcgctgatca taccgacgga atattcgctg gaaagcggaa aacaggcagc
    13861 gggcgagctg tttgacagag accttccgac cgccgttttc gcctttaatg atgtcttgtc
    13921 atgcgcggcg atacaggcgg cgcgctcccg gggcattcga gtgccggaag acttgtccgt
    13981 catcggcttt gacaatacca ttctcgctga aatgacggca ccgccgctca cgacgatttc
    14041 tcagcccatc cgcgaaatgg ggcggcgtgt cgttgaactt ctcattgatg agattcaagg
    14101 gaagaaaaaa acaaaaagca aaatcatttt atctccggaa ctcgtcatca ggcattctac
    14161 ggcaccggta aaaacgcgcc ctcagcaata aggcgcgttt ttttctgtga aaaacattgt
    14221 caaacgagcg aaaagcattg taaaattaaa acagcttttg ggaaagcgct tgcgcaaata
    14281 ctgcggattg caagcaaaga aagccaacag cttgagttgt aaataaagcg ctttcaaaat
    14341 aatgatttct gtttaataag ggaaaccgct tgcgccattg cggcatgcgg cctcaagaaa
    14401 aaaggagcgg tgatagatga cagatcaagt cagatgtgcg gtgctgggat taggacgatt
    14461 agggtatttt catgcgaagc atttagccgg cgaagttcgg ggagccgagc ttgcggccgt
    14521 ctgtgacccg atgaagggaa aggcggaagc gtgtgcaaaa gaattaggaa tcgccaaatg
    14581 gacggagaat ccgtatgacc tgttggaaga tcacacgatt gacgccgtca tcattgtcac
    14641 accgacaagc acacatgcgg aaatgatcat gaaggctgct gaaaacggca agcacatctt
    14701 tgttgaaaag ccgctcaccc tgagtcttga ggaatctaaa gaagtcatga aaaaaatcga
    14761 agaaacgggc gtcatctgcc aggtcggttt tatgaggcgg tttgatccgg catacgccga
    14821 cgcgaaaaga agaatcgacg ccggggaaat cggcaggccc atttattata aaggatttac
    14881 aagagatcaa ggcgcaccgc ccgcggaatt tatcaaacat agcggagggc ttttcattga
    14941 ctgttcgatt catgattacg acatcgcgag atatctcatg aatgccgaag ttacgtccgt
    15001 ctgcgggcac gggagaattt taaagcaccc gttcatggaa aagtgcggcg acgttgatca
    15061 ggcattaacg tatcttgaat ttgattcggg cgcggccggc gatgtggagg caagccgaaa
    15121 ttctccgtac gggcatgata tccgagccga aattatcggg acggcgggaa gcatcttggt
    15181 cggtacgctg cggaaaagcc atgtcaccat tttaactgag tcaggcagca gctacgaaat
    15241 tattccggat tttcaagccc gctttaaaga cgcttaccgt ctggagcttg agcactttgc
    15301 cgaatgtgtg aaaaaagggg aaacgccgat tgtgacagac gtcgatgcca cgattaactt
    15361 agaaatcggg atcgccgcga cggaatcttt taaaaccgga aggcctgtaa agcttacccc
    15421 gggcgccttc ggatatgccg gattatgata gattcgaagt gaaaaagcaa aggcccggaa
    15481 ggcctttgct tttttatgat tcgtatgaga aaaaaatgta gtcagtcggc acgcttttat
    15541 agcccatttg gtgaagcatc gcgcttatat tgccgcgatg gtatgtgccg tgattcacaa
    15601 catgccggat cacatcggca tatgtcgtcc ggagcgttcc catgcgcgga tgagaaatgg
    15661 agatcgggcc ttccgtgttc tccaattctc ttaaaaattt gctgtattct ttgtccagtt
    15721 cagccattct atgttcaatc gcctcaaaat ctccgtcaag cttttcaaat tgatcaaact
    15781 gcgagacgat ttgttcgtaa gtttctccgt aaagcacgtg aagccaaatg taatcagccc
    15841 ggtatatatg cacaagcacg gcgttcacag tcggaaaaac actatccagt ttctgctgta
    15901 agcttgccgc gggcagggtc ttcagatgct gaataacctg ctcatttgcc catctgtggt
    15961 agtgatacag ctttaatatg tctgacattc caattccccc tcttccttcc ggtacattca
    16021 acatggcctg gccgaattcc ttttatcgga acaaaagcgc cgcaaaataa aaagcagcac
    16081 cccacatcac caatgccgag catttattca ggatgtcgag gagccggcct cctgtatccg
    16141 ccgtttggac gagccgtccc gcgaatgcca gtccggcgaa ccatacccag gaaaccgcga
    16201 tacaagcact ggcaaacagc catttatcaa ttcccggata ggcggcggag cttgtgccga
    16261 tgacactgac ggtatccaaa atcgcatgcg ggttcaaaag ggataccatg gcggccgtga
    16321 ccgcctgttt ttttgccgag aaaaccgttt ttttcgcctg ttcggcctgc ggtttgcttc
    16381 tccaagtctg ccagcctaaa aaactgagaa acaaaaagcc gcctataagc atgacggtct
    16441 gaaaaacggg aatctctgca ataatcattg aaacgcctgc gacggccgcg atgatgagaa
    16501 tcgtatcgca taccgcggcg gcaatcactg cgggaaacgc ctgccacaca tgtttttgcc
    16561 aggctccctg ctgaaaaata aatacatttt gcgcgcccaa tggcaaaata aggccgaaag
    16621 cgagcatcac tccgtgaaga atggcattca tatcgtaaaa ccctccaatc gtcaactaaa
    16681 tctcattgta gccgcactat gtgctgatgt ctccgtccat ttggctggta cttgaaccag
    16741 ccaaatgtat aataaataaa gaaggaggga tgacgtatga acagctggcg tccggatcgg
    16801 gagtcgtaca taccgcttta tctccagatc gaacagcata taaaagaaaa aatacttcat
    16861 ggcgaatgga ccatcggcac gaaaattccc tcacaaagaa agctcgccga ggagcttcag
    16921 gtcaaccgaa gcacagtgac ggcagcagtt gatgagttaa tcgcccaagg tcttctggaa
    16981 ggaaaaagag ggggaggcac aaaagtcgtc aacagtacgt ggagcatcat ggcagcggct
    17041 aagccccttg attggagcac atacgttaca tcggggagtc atcagccgaa ttcagccttg
    17101 gttcaggcca ttaatcaaaa cgagccgcgt ccggatctga tcaggctggg gacgggtgag
    17161 ctgagtcaag agcttctgcc tgagaaggag atggccgaac tgttccgtga agcgggaact
    17221 aacatttttg cgctcggcta tgaagagccg aagggcagcc tgaagcttcg gcaaagcgtc
    17281 gcggaatatg taaaaacaaa ggggattcac gcgtccccgg catccatcgt aatcgtctca
    17341 ggcgcgctgc aggcgcttca gctcatttca atcgggctgc taaaaccaaa ctccgtcatg
    17401 ctgactgaaa acccgtcgta tctccattcc ctgcgtgtgt ttcaatcagc gggcgtcagg
    17461 cttaagggag tgccgatgga tgagagcgga atcaaaacgg atcatcttcc cgcttaccgt
    17521 cggcaatacg aagcggggct gctgtacacc attccgtcat tccataatcc gaccggaacg
    17581 gtaatgtcac tcaagcggcg gaaggaactc atcgcgctcg caagaaatca ccgtctgcct
    17641 gtcattgaag atgacgcata cggtgatata tggatcgata aagaaccgcc gcctccgtta
    17701 aaatccatgg acggtgaggg gaatgtactg tatatcggta cgctgtcaaa aaccgtaagc
    17761 ccgggtctgc gcatcggatg ggtcgtcgcc cctgagccgg ttgcagacag gctcgccgat
    17821 attaaaatgc agacggatta cggctccagc gctttatctc aatgggcggc atgtcaatgg
    17881 ctgtcaagcg gccgctatga agagcgtctt ttgcgtctca gaaaggaact caaaatcagg
    17941 agagatgcgg cattgcgttt tcttgaaaga tacgcggaag atattgcgga gtggcgtgtg
    18001 ccggaggggg gcttttacat ttgggtcact tttcatcaaa caatcgccgt tcagaagctt
    18061 ttcacccgtg ccttggaggc cggcgtgctg atcaatccgg gagctctcta tcttcccgaa
    18121 gaccggcaaa gcctgcgtct ttcctattca tacgcatcct taccgggctt ggaaaaaggc
    18181 attcaaacga tagcggacat tgcccgccgt ttcgtttaat aaaaagatca cgtcacaatg
    18241 gctccgagcg cttctgcgaa tgtaacggca tgagacggag agatgcggca tcctttcagc
    18301 ttctcaagtg agacgtgcag gtgatcaaat gtgcacgtgc tgatatccat attaaaaaga
    18361 gacgtgccga tgaagtttgc gccgttcaaa tcacagacgt caagatctgt gtattcaaga
    18421 acggcatcat tccactcact ttctgatagg ccgcacgtgt caaaccggac atgcttcata
    18481 ttggaatagc tgaaggagct gtaatgtgcg aggcagtctt caaaccgtac atgacgcatg
    18541 gcggaatccg ccagattcaa gccgagaagt tttgaatgct gaaacgccgt tctatggatg
    18601 atgcttccgc tgaagtcagc gtttgagaca tcacatttgt caaacaggac atccgtacat
    18661 tccatatgtc tgaaagagac atccgtaaaa acggtgtttc tgaaaatgac tttttcggcg
    18721 cgcaggccgt ccagtttgcc gcttatcacg gcgttttcta tgacgacttc tttgatgagg
    18781 tcgtcctgaa gcgcttcagt gaaagaaagc accggcaatt ctttcgggat tttcggtttt
    18841 tggatcgtat tcatctcata ctcccttttc taaacataat agctgaaatc ggcaattggc
    18901 agatatcact ttcgcccctg ccacccttgc cgaatggcgt gttgcttact gaacaaaggg
    18961 taatatcaaa gcgggatcgc gtcaatagcg gcgcttataa aagcttcatt ccgtttgaac
    19021 gtcatccggc ccgctgaaag ataaaaacaa agccttgata agagggcttt tgtctgtttc
    19081 aggcgagttc tttatacatg atcacatgcg ggccgatgcc gggaatatca aaggggctgc
    19141 ccgtgctttt ccagccgagc ttttcgtaat atccctttac gtgacatctg gcgttgcacc
    19201 agacaagcgc cgcccccata tctgccagtt tccgttccgc ataggcgatt aacgtgcttc
    19261 ccgctttttg cgtccggtat tcctcaagcg tcgccatgcc gcgcagctgg taggcgggcg
    19321 ctgcctgtaa agcctgctgg ttctgcgggt agaaagaagc gatgctgatc aatgttccgt
    19381 cgtaaaaacc tccgagatga aaggctcctt tgacgctgtc ctgatcatat ttacaatcct
    19441 caatcgtctg atgggggcgc agcacgctgt gtctgatcgc gtatgtgtct tctgcggtga
    19501 tgggttttac ttcaaccatg aaaaaatcct cctttgcttg attctttttc tgtatcgtac
    19561 catgaaaaag ccgcctgtca tatcaggcgg cttctttcgc gtcaatgcaa atatacatca
    19621 gcccgctttt catccttttg cttaatataa gctgcaagct ctgacgtcaa atcagaacgg
    19681 agaaacgggg tgattaaata aattccgtta aacagttcgc acgccgtgtc gagaagcgat
    19741 ttggcgatgg cgaggccttc ggctttctgc tttcgcttgt cttcgccggc gagcgccatt
    19801 ttttcgcgga tgctgtctga cagcttaatg cccgggattt catgatgaat gaactctgcg
    19861 ttgcggctgc tcgttaacgg catgattccg atatacaccg gtgttttgag atgcttcgtt
    19921 tcatgatgaa tgtcaatgag ctgctgctcc gagtagacag gctgggacac gaagtagtca
    19981 gctccgcact cgattttttt ctccagccgt ttgactgctt tatcaagatg gcggacattc
    20041 ggattaaatg ctccggctac ggaaaagttc gttttcttgc cgagcggttt ccctgataaa
    20101 gaaatgccct cgttgaattg tttaatcagc ctgatcaaat caaaggacgt taaatcatag
    20161 acggaggtag cccccggaaa gtcaccgatt tttgaaggat cacccgtgat ggctaaaatg
    20221 tcggtgagcc cgagcgtatc cagccccatt aaatgtgact gaaggccgat gatgttgcgg
    20281 tctctgcatg taatgtgaac gagagaacgg atatcaaggc gctctttcag caatgaaccg
    20341 caggcggcat tgctgatccg cggtgtcgcc aatgaattgt cggcgagcgt cagcgcttct
    20401 atgccggtct cttttaattc agcggccgct tgcagaaatt tgtcaaaatt caatttcttc
    20461 ggcggatcaa gctctacgat aattgaccgt ttttgagcgg cgatttcgtt taaaccaggc
    20521 tcggtccgtt cattacggac tgagatgact tcctcttccc gtctgatttt cacttcttta
    20581 tcagtgacag gagaaagtcc gcggaccgct tcagccatgg ctctgatatg gtttggcgtc
    20641 gtaccgcagc agccgccgat aatgcgcgcg ccctgagtgc ggaactgtac ggcgctctcc
    20701 cggaaatagg catcgtccgt atcataaaca agccggcctt c
//
