LOCUS       NZ_CP058693            22646 bp    DNA     linear   CON 08-SEP-2024
DEFINITION  Streptomyces sp. Rer75 chromosome.
ACCESSION   NZ_CP058693
VERSION     NZ_CP058693.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Rer75
  ORGANISM  Streptomyces sp. Rer75
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Genome analysis of Streptomyces sp. Rer75
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-JUL-2020) College of Pharmacy, Henan University of
            Chinese Medicine, Jinshui East Road No. 156, Zhengzhou, Henan
            450046, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. Canu V1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 76.63x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013414305.1-RS_2024_09_08
            Annotation Date                   :: 09/08/2024 05:25:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,857
            CDSs (total)                      :: 8,765
            Genes (coding)                    :: 8,460
            CDSs (with protein)               :: 8,460
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 305
            CDSs (without protein)            :: 305
            Pseudo Genes (ambiguous residues) :: 0 of 305
            Pseudo Genes (frameshifted)       :: 145 of 305
            Pseudo Genes (incomplete)         :: 204 of 305
            Pseudo Genes (internal stop)      :: 20 of 305
            Pseudo Genes (multiple problems)  :: 62 of 305
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:27:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6316065
            Orig. end                         :: 6338711
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058693.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22646
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="23"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22646
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22646
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12646](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12646
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(66..1340)
                     /gene="xseA"
                     /locus_tag="HYQ63_RS27410"
                     /old_locus_tag="HYQ63_27410"
     CDS             complement(66..1340)
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005480697.1"
                     /locus_tag="HYQ63_RS27410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27410"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_179936556.1"
                     /transl_table=11
                     /translation="MALNTSAEAPIPVGEVSRLIGGWIDRLGAVWVEGQITQLSRRPGA
                     GVVFLTLRDPSYDISLTVTCFRAVFDKIADTVSEGARVVVHAKPEWYAPRGQLSLRAAE
                     IRPVGVGELLARLEQLKKSLAAEGLFAAERKKPLPFLPQLIGLVCGRASAAERDVLENA
                     RLRWPAVRFEVRNVAVQGTHAVPQVIEAVKELDALPAVDVIVVARGGGSVEDLLPFSDE
                     QLVRTVAACRTPVVSAIGHEPDSPLLDLVADLRASTPTDAAKKTVPDVGEELVRIQHLR
                     ERALRSVNGLLDREERGLESALARPCLRQPHRMVEEREEQIASVLDRARRCLGHLLDRA
                     DSELAHTQARVVALSPAATLRRGYAVLQHADGSVVRAAAEVSADEELRARVAEGEFTVR
                     AVGGSAGAVGPTGAVEPAEAVGPTE"
     misc_feature    1346..1360
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            1394..2434
                     /locus_tag="HYQ63_RS27415"
                     /old_locus_tag="HYQ63_27415"
     CDS             1394..2434
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715339.1"
                     /locus_tag="HYQ63_RS27415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27415"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_373689147.1"
                     /transl_table=11
                     /translation="MGDMTATSARRVLLAAPRGYCAGVDRAVIAVEKALEQYGAPIYVR
                     KEIVHNKYVVQTLEKKGAIFVDETEEVPEGSIVIFSAHGVAPVVHEEAAQRKLATIDAT
                     CPLVTKVHKEAVRFAKEDYDILLIGHEGHEEVIGTSGEAPDHITLVDGPDDVKNVEVRD
                     ESKVVWLSQTTLSVDETMETVDALQDRFPQLISPPSDDICYATQNRQTAIKQVAAESDL
                     VIVVGSKNSSNSVRLVEVAIGAGAKDGHLVDYASEIDEAWLEGVTTVGVTSGASVPDVL
                     VEGVLEWLAERGFGDVEVVQPMQESLTFSLPKELRRDLRSEASAAAGTSAGTSAATSAG
                     TNGAEQ"
     gene            2431..3228
                     /gene="ppgK"
                     /locus_tag="HYQ63_RS27420"
                     /old_locus_tag="HYQ63_27420"
     CDS             2431..3228
                     /EC_number="2.7.1.63"
                     /GO_function="GO:0004340 - glucokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0047330 - polyphosphate-glucose
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ppgK"
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715338.1"
                     /locus_tag="HYQ63_RS27420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27420"
                     /product="polyphosphate--glucose phosphotransferase"
                     /protein_id="WP_179936558.1"
                     /transl_table=11
                     /translation="MTNEHGGGQAARVFGVDIGGSGIKGAPVDLDRGDLAEERHKVLTP
                     HPSTPEAVVDGVVEVAEHFGWSGRPVGVTFPGVVTDGTTRTAANVDKSWIGTDLAGLLG
                     ERLGAPVTVLNDADAAGVAEMTFGAGRGRQGTVIVLTLGTGIGSAVFTGGRLVPNTELG
                     HLELDGHEAEKRASTKVREDHDLSWPHWAHRVQKYLAHLEMLFSPELFVIGGGVSRKAH
                     KFLPLIEDIRAEIVPAQLQNNAGIVGAAMAAAAAADGAAAAAP"
     gene            complement(3122..3784)
                     /locus_tag="HYQ63_RS27425"
                     /old_locus_tag="HYQ63_27425"
     CDS             complement(3122..3784)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014054630.1"
                     /locus_tag="HYQ63_RS27425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27425"
                     /product="DUF6542 domain-containing protein"
                     /protein_id="WP_257232182.1"
                     /transl_table=11
                     /translation="MEHYRTRTPRRAAAPSPRPAADDTYPGRGQGGRQSAGGAARGARP
                     VARPGGRSGLLGAAATLRDRPVTLPSARLTALGAGLLTALAMLAFGCVDALLFSGSPTA
                     YGVFFLLACAGCGMWVRPADLFPGAIGVPIAFTAGLLPINDGGAGFAGQALGVFTALSL
                     NAGWLYAGTLLTALIVLVRKIALMGRQRRRRQQRQPRPSRHPRSPHCSGAEPGRSRP"
     gene            4005..5093
                     /gene="ychF"
                     /locus_tag="HYQ63_RS27430"
                     /old_locus_tag="HYQ63_27430"
     CDS             4005..5093
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ychF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058470.1"
                     /locus_tag="HYQ63_RS27430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27430"
                     /product="redox-regulated ATPase YchF"
                     /protein_id="WP_179936559.1"
                     /transl_table=11
                     /translation="MSLTIGIVGLPNVGKSTLFNALTKNDVLAANYPFATIEPNVGVVG
                     VPDPRLDKLAELFGSARKLPATVDFVDIAGIVKGASEGEGLGNKFLANIRESDAICQVI
                     RAFKDENVVHVDGKISPKSDIETINTELILADLQTIEKVLPRLVKESRIQKDKQAQVKA
                     VEEAKAILDEGRTLFSAGIVQGSERAALLHDLHLLTTKPFLYVFNVDEDELTDEDFKAE
                     QRSLVAPAEAIFLNAKLEADLAELDDEEALELLQSVGQTEPGLATLAHVGFNTLGLQTY
                     LTAGPKESRAWTIKRGATAPEAAGVIHTDFQKGFIKAEVISFDDLVETGSVADARSAGK
                     ARMEGKDYVMRDGDVVEFRFNV"
     misc_feature    4050..4063
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    5114..5129
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.15"
                     /tool="antismash"
     misc_feature    complement(5392..5412)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.21"
                     /tool="antismash"
     misc_feature    5726..5740
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.78"
                     /tool="antismash"
     gene            6057..7184
                     /locus_tag="HYQ63_RS27435"
                     /old_locus_tag="HYQ63_27435"
     CDS             6057..7184
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="HYQ63_RS27435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27435"
                     /product="sensor histidine kinase"
                     /protein_id="WP_179936560.1"
                     /transl_table=11
                     /translation="MPVGFFVASVVATAANRDGVRHLAVASAVLALNLGLHLLHSTRAA
                     VRRRKPWWPWSLVAHGGVTYAPYVFFQDTWVGIPGSFAAAVLLTTPVPHSWTAFVALSV
                     LQVPLVVALGETAWQGLNSAVSHVVGGLALFGVVRLADLAEELQAARTELAQQAVDRER
                     LRFARDLHDLCGYSLTAVALQSEQIQWLVHSDPQRAEKELARIQALARHALSEVRAVSA
                     GYRTLTLEREARTAADLLESLGVDVDVELAGRLLPRPVDETLAIVVREGVTNALRHSKA
                     RRCAIRFTVDSGQADGGWARLDVTNDGLAPGQVGEAGRRLLEGAGSGLRNLRERVAERG
                     GVLTAEADGEGGFRLEATLPCASRDTAENGVSGRA"
     misc_feature    6603..6605
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7208..9691)
                     /locus_tag="HYQ63_RS27440"
                     /old_locus_tag="HYQ63_27440"
     CDS             complement(7208..9691)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024116.5"
                     /locus_tag="HYQ63_RS27440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27440"
                     /product="ABC transporter permease"
                     /protein_id="WP_179936561.1"
                     /transl_table=11
                     /translation="MALALALIMTTACAVLLESSTRAESRTERYAGTDVVVAGQPFVPR
                     AGELRTALERLPSVERAVPELSVPTTAVDTSGKPVEAPWDGPFLGHSWESAALGPFALR
                     QGRAPAGDAEVVLDGALAGRLDAGVGDTVRLAGPDGLRPYQVSGVADPPRRLARQYAVF
                     HTSREAERLAESDQPVRAVGVLAEGTTDTAALRRQVEKAVTSLYGDDAWSLVVASGAGR
                     AEAEFWGVPSPASTLSSLVGTFGVLSLFVAGFVVSGTLTFAVAGRMTEIGLLRAVAATK
                     GQIRRMIAVEVLLMTVAAALLGVPGGIGVAMLLHRGLVNGEVLPPSFALSVGPVAPWAT
                     IVLAAVVAQLAAFAAARRASRVRPVDVLRESAAPTPKLGPRRVLLGMGVLAGAGGCLGA
                     VATGRLDGGGGTTESMVLVLMIGMALLAPLICRVAGALFLAPVTWFLPREGALAVRNLL
                     RQNARLAATVTPLVLALSLTGTLRCVPLVTSQGAQRAEQQRLLADHVVSSAGPGIAPGY
                     AERAARLPGVAAASGQLTVDGELSRADAGQDDDASIFGGSLVAMRAEAVPDLLDLGVRA
                     GSLARLGDSSVALGAGAARSLSVTVGDRVRVDWDDGGRDTYRVAAVYSRDQGFADALLP
                     RASAARHAAAPVDDTVLVRTAPGDDRGAVERELKTLAADFPGARISDGATEREAESGAA
                     ANLFVLLLLTMINLFTSIAVINTLSMATAGRRREFALLRLAGAQSAQVLRMLAWEAVLT
                     CVVALLLAALVCASVLVPLSIAVTGSAVPALAGGPLAALAVGAPMVAVATVTVAGRLAM
                     RSAAAMPGGLARAVS"
     misc_feature    9875..9890
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.6"
                     /tool="antismash"
     gene            10001..12646
                     /gene="lanKC"
                     /locus_tag="HYQ63_RS27445"
                     /old_locus_tag="HYQ63_27445"
     CDS             10001..12646
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004940773.1"
                     /locus_tag="HYQ63_RS27445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27445"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_179936562.1"
                     /sec_met_domain="micKC (E-value: 2.2e-246, bitscore: 819.0,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 7.8e-11, bitscore: 40.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 6.4e-06, bitscore: 25.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.8e-19, bitscore:
                     68.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYDAYCMVDRTFFDAPGEAQDQEYAFAATDRELPEGWRKVRQDD
                     WLVCTPEGTRRPAQGWKVHASGCQDNAEKILDAVHNFCVPRGIPFKFLRGQHILQLRNM
                     KYASRGASGKLVTIYPADEAELREVLEGVEALVGGEPGPYILSDLRWHQGPLYVRYGGF
                     VERHVVSEKGVLEPAVERPDGTLVPDRRLPGFHVPDWVTLPEFLQPHVEARRAESLAGL
                     PYAVRRPVHFSNGGGVYIAEDTRTGKEVILKEARPYAGLTADGRDAVTRLQWERDVLER
                     LAGLDAVPAVVDYFTVGDHHFLAQELVGGQPLSKFFGLKYPETGPRADPEEIAGYTEWA
                     MGVCRAVERAVVSVHERGIVFGDLHPYNIMVGDDGRIGLIDFEVAAPVESGAVRMLGHP
                     AYAAPGDRKGFAADTYALACIKLAVFLPLTALLRLDLHKAAELADEIAARFPVPREFLD
                     SAVREILGESTGASGGPAGSGPAVERGQTDGRGGAVRDRLRGRDGRPPRPGPDRRSWPA
                     VRGSLAGAILASATPGRDDRLFPGDIAQFSTGALNLAHGGAGVLYALDVTGAGRYPEHE
                     QWLLERSLRREQRARIGFYDGLHGVAYALDHLGHHDDARQVLDRCMGEKWQRLGTDLYS
                     GLAGVGLNLLHFAERTGDSGLRVAALEVAGTVAERLGSDTDVPEVSGGQHPKAGLMHGS
                     SGPALLFLRCYEATGDHVFLDLAATALRQDLRRCLTREDGALHVNEGWRSLPYLAEGSA
                     GVAMVLDLYLAHRDDDRFRAAAAGALISSSSQFYVQSGLFNGRAGIINHLGAVSPERTP
                     AADPLLAAQIDALSWHALEYQGELAFPGEQLLRLSMDLATGSAGVLLALGAALHTGPVH
                     LPFLGRHRPA"
     misc_feature    10027..10040
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.82"
                     /tool="antismash"
     gene            12726..12839
                     /locus_tag="HYQ63_RS44925"
     CDS             12726..12839
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYQ63_RS44925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_248500420.1"
                     /transl_table=11
                     /translation="MSLLELQEMELPTESSEETVLGSGRSQHCSDASWVFC"
     CDS_motif       12726..12782
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSLLELQEMELPTESSEET"
                     /locus_tag="HYQ63_RS44925_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12783..12839
                     /prepeptide="core"
                     /locus_tag="HYQ63_RS44925_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="9.10"
                     /molecular_weight="1867.1"
                     /monoisotopic_mass="1865.9"
                     /core_sequence="VLGSGRSQHCSDASWVFC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSLLELQEMELPTESSEET"
                     /leader_location="[12725:12782](+)"
                     /alternative_weights="1885.1"
                     /alternative_weights="1903.1"
     gene            12912..13025
                     /locus_tag="HYQ63_RS44930"
     CDS             12912..13025
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF039607.4"
                     /locus_tag="HYQ63_RS44930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_248500420.1"
                     /transl_table=11
                     /translation="MSLLELQEMELPTESSEETVLGSGRSQHCSDASWVFC"
     CDS_motif       12912..12968
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSLLELQEMELPTESSEET"
                     /locus_tag="HYQ63_RS44930_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12969..13025
                     /prepeptide="core"
                     /locus_tag="HYQ63_RS44930_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="9.10"
                     /molecular_weight="1867.1"
                     /monoisotopic_mass="1865.9"
                     /core_sequence="VLGSGRSQHCSDASWVFC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSLLELQEMELPTESSEET"
                     /leader_location="[12911:12968](+)"
                     /alternative_weights="1885.1"
                     /alternative_weights="1903.1"
     misc_feature    13083..13098
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.02"
                     /tool="antismash"
     gene            13184..14947
                     /locus_tag="HYQ63_RS27450"
                     /old_locus_tag="HYQ63_27450"
     CDS             13184..14947
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483996.1"
                     /locus_tag="HYQ63_RS27450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27450"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257232189.1"
                     /transl_table=11
                     /translation="MTVRQPLESAARLPGRAADRILLCTTREGGVWTTVLVITAVFSTT
                     AQILFPAFLGKALDSALDGGGGASGWTIGCLLAVTAMAAADALFELAAGAGAACGTALL
                     RRSMLATLLSWSGPGGPRTTAGDMVSRLVGAAAEAGGVAAVLVRAALSIVPAVGSVVAL
                     FVIDPWLAGTFLLGLPAVVLLLRAFTRHISDVSVRYQETQGRLATALLEALTGRRTIAA
                     AGTADAEVRRVLRALPELNRLGHGMWQAQTQAAGRSALLTPLLEIAVLSVAGFALAAGR
                     ITVGEMLAAAQYVAIGSGLGMTTMLLGRLARARAAAERVHGALAQPVLEYGDRRLPPGP
                     GHLELRAVQVTAGGERVLDGVDLTVPGGTCTALVGASGSGKSLLAAVAGRLTDPDAGAV
                     VLDGMPLGQLTHRDLRSAVGYAFERPVLFGETLGDAIARGTGRTAGDVPEERIVVAARA
                     ADVDGFVRRLPDEYRTPLGEASLSGGEVQRIGLARAFVHSGRLLILDDATSSLDTVTEH
                     RISQVLTGALRDRTRIVVAHRAATAARADSVVWLDGGRVRRVGPHHELWRTEPEYRRVF
                     RGAEAVEEEPS"
     gene            14971..16788
                     /locus_tag="HYQ63_RS27455"
                     /old_locus_tag="HYQ63_27455"
     CDS             14971..16788
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004151.1"
                     /locus_tag="HYQ63_RS27455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27455"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_179936563.1"
                     /transl_table=11
                     /translation="MLPVLIAPLRARPDRLLALVLWSLVEAVPALLAGHLVARAVDQGF
                     AAGRPLIGLAWLALMGLGVFAGAWGTRQAYPLLAEVVEPFRDDLVRKVAEDSLRQAVAG
                     RAVDASGVSRLTLQVEMVREAYAGVLMVVRGFLLTVGGALLGMVFLAPLILLLVVPPLL
                     VGLGLFLVLLRRMATAQRDVIVADERVAEAAGAACAADRDIVACGAKDGVRADLVEHID
                     AQAAAARRLAVLMPARVLCLAVAGWLPLLLLLTAAGRLVDGGLSAGAVLGAATYVTGGL
                     QPAVRSLIQGLGGSGLRLVVALRRIHEAQGPTASPADPARGADPVPGATSQPPLTTAPT
                     AYDVELTAVTFAYGPQAAPVFRELDLTLSEGGHLAVVGPSGIGKSTLAGLIGGTLEPDS
                     GLIRLGGRPPGALPGADLSALRVVVPQEAYVFSGDLCENLRYLCPDASEHEVVAAVESV
                     GAGPLVARLGGIGAVIDPAALSSGERQQIALVRAYLSPAPLVLLDEATCHLDPAAEARA
                     EEAFARRPGSLVVIAHRISSALRARQVLVLDGSRVVSGAHGEVLERSPLYRDLVGLWSE
                     DGQEPLAGSDEASPTVGGIVRATPPRSRS"
     gene            complement(16757..17359)
                     /locus_tag="HYQ63_RS27460"
                     /old_locus_tag="HYQ63_27460"
     CDS             complement(16757..17359)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006130564.1"
                     /locus_tag="HYQ63_RS27460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27460"
                     /product="response regulator transcription factor"
                     /protein_id="WP_179940566.1"
                     /transl_table=11
                     /translation="MRVLLAEDAPLIRQALTALLSQEPDLEVVAAVDHGDLIVPTALRT
                     PPDVAVLDIDLPGTDGITAAVELHARLPSCRTLVLTSVARPEHVRRALSAQVVGFVRKD
                     APTARLAEDIRQVAQGRRVVDPELVLAAATATENPLTPREVSVLRLTAQGASARDVAAQ
                     LYISVGTVRNHLASAVAKTQARSRVDAIRIATEAGWL"
     misc_feature    complement(17144..17146)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17467..>17667)
                     /locus_tag="HYQ63_RS46100"
                     /old_locus_tag="HYQ63_27465"
                     /pseudo=""
     CDS             complement(17467..>17667)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013003.5"
                     /locus_tag="HYQ63_RS46100"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27465"
                     /product="pentapeptide repeat-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LYRSDAQGADFTGADLTRASRRGTRFMGASLTTKERAPCPVVCRP
                     GPVRRATPGGCISWPVCFLLT"
     gene            complement(17696..19132)
                     /locus_tag="HYQ63_RS27470"
                     /old_locus_tag="HYQ63_27470"
     CDS             complement(17696..19132)
                     /EC_number="3.4.11.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715321.1"
                     /locus_tag="HYQ63_RS27470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27470"
                     /product="M1 family metallopeptidase"
                     /protein_id="WP_179936564.1"
                     /transl_table=11
                     /translation="MSPQAAHPRRTVPQRPARLLPGALLLAPLLLLSTSCTGPSHEAPP
                     APGAAGKGDPLFPRLGNGGYDVTHYRLALDYTPGTHRLRGTARITARATRALSSFHLDL
                     AGLYVRETTVNGRSARATRDGTELTLTPAAALPEGRTFTTTVVYDGKPKAITDPDGSRE
                     GWLRTTDGAVGLGEPTGSMTWFPGNNHPSDKATYDITVTVPRGYAAVSNGELTRRDTHN
                     GRTTHHWRTHDPMASYLATVAIGHFDIHTTTAHGLPQYVAIDPEEADASRDVPDQIAKI
                     TAWERRTFGPYPFASTGAIVDRLPELGYALETQTRPYFAAAPDERLIVHELAHQWFGNS
                     VTPRAWKDMWLNEGFATYAEWLWTEQHRGRTAQQTFDAFYDGTDDESKGIWSFPPATPP
                     SPGHISDPPVYGRGAMALHQLRRAVGDRTFFRILRTWPRDHRHGNADTRQFIALSERLS
                     GKDLSKLFDTWLYTKGKPKR"
     gene            19284..20036
                     /locus_tag="HYQ63_RS27475"
                     /old_locus_tag="HYQ63_27475"
     CDS             19284..20036
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545280.1"
                     /locus_tag="HYQ63_RS27475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27475"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_179936565.1"
                     /transl_table=11
                     /translation="MAFGDQPAYLRVADDLRKKIVAGDLPPHARLPSQARIREEYGVSD
                     TVALEARKVLMAEGLVEGRSGSGTYVREQPVPRRLVRTGYHPRGESSPFRQEQGDDRVS
                     GTWDCGSEQEEASPEIAERLRVEPGERVMRTRYLFRAAGEPVMLSTSWEPLAVTGRTPV
                     MLPEEGPLAGRGVVDRMAAVDVVVDNVAEEVGARPGLAEEVLALGGVPGHVVLVISRTY
                     FAGGRPVETADVVTLAERYRVAYHLPVK"
     gene            20231..22003
                     /locus_tag="HYQ63_RS27480"
                     /old_locus_tag="HYQ63_27480"
     CDS             20231..22003
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715319.1"
                     /locus_tag="HYQ63_RS27480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_27480"
                     /product="cytosine permease"
                     /protein_id="WP_179936566.1"
                     /transl_table=11
                     /translation="MTDTVTPDQTQTGSTAARAPRRSYARLAADESREDYSLRYAPHSY
                     RRWSPTMVASTALGGIAYLADFAIGASIVFTYGFTSGLASILTAATIIFLTGIPIARAC
                     ATYGLDMDLITRGAGFGYFGSTLTSLIYASFTFIFFALEGSIMAQAMQQALHIPLPIGY
                     LITTLIVIPIVFRGMGALAKVQAWTQPLWLIGLVLPFVVLAFERPDAWASFASFGGTEG
                     AGSGFDWIGYGLGTGVALSLIAQIGEQADYLRFMPAKTEQNRRRWNLAVLAAGPGWVVI
                     GAAKQLGGAFLAFVALGAVGTTHALEPIAPQIEALKPWLGSVALPAAALFVVVSQIKIN
                     VTNAYSGSLSWSNFFSRVTHRHPGRVWYIFLNLAIALALMEMNMFAALNKLLGFYSNVG
                     IAWIAAVTADLVINKPLGLSPKYIEFKRAYLYAVNPAGFGAMVIASVVSIIAFFGVFGE
                     VAEAFSTFIACGLALVLSPLLAWLTRGRYYLARPNPVNGPGVEVPDVTAVHTCAVCETA
                     YELPDIADCPVRAGAVCSLCCSLDAECGDACRKGPKGSHGAAPVLLPVPTVRASGARRA
                     SGARRASGARASDG"
     misc_feature    complement(22497..22512)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.67"
                     /tool="antismash"
     misc_feature    complement(22535..22552)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.82"
                     /tool="antismash"
ORIGIN
        1 gctcgtaccc gagcgtcgtc tccgccgccc cggccttctc gtccgtcttc gccatgcccc
       61 tcagcctatt cagtaggtcc gacagcctcg gcaggctcga cagctccggt ggggccaaca
      121 gctccggcgg atccgccaac ggcccgcacc gtgaactcgc cctccgcgac ccgcgcccgc
      181 agctcctcgt ccgccgacac ctcggccgcc gcccgcacca ccgacccgtc ggcgtgctgg
      241 agcaccgcat agccgcgccg cagcgtcgcc gcgggggaga gggccaccac ccgggcctgg
      301 gtgtgcgcca gctccgagtc cgcccggtcg agcagatgcc ccagacagcg ccgggcgcgg
      361 tcgagcaccg aggcgatctg ctcctcgcgc tcctccacca tccggtgcgg ctgccgcagg
      421 cacggccggg cgagcgcgga ctccagcccc cgctcctcgc ggtccagcag cccgttgacg
      481 ctgcgcagcg cgcgttcgcg cagatgctgg atgcgcacca gctcctcgcc cacgtccggc
      541 acggtcttct tcgccgcatc cgtaggcgtg gaggcgcgca ggtccgcgac cagatccagc
      601 agaggcgaat ccggctcgtg gccgatcgcg gacaccaccg gcgtacggca cgcggcgacc
      661 gtccgtacga gctgctcgtc cgagaacggc agcaggtcct ccacgctgcc gccgccgcgc
      721 gcgaccacga tcacgtccac cgcgggcagc gcgtccagct ccttgaccgc ctcgatcacc
      781 tgcggcaccg cgtgggtgcc ctgcaccgcg acgttgcgca cctcgaagcg gacggcgggc
      841 cagcgcagcc gcgcgttctc cagcacgtcg cgctcggcgg ccgaggcgcg gccgcagacc
      901 agccctatca gctgcggcag gaacggcagc ggcttcttgc gctcggcggc gaacagcccc
      961 tcggccgcca gcgacttctt caactgctcc agccgcgcca gcagttcacc gacgcccacc
     1021 ggccggatct cggcggcccg cagggacagc tggccgcgtg gcgcatacca ctccggcttg
     1081 gcgtgcacga cgacccgggc gccctccgag accgtgtccg cgatcttgtc gaagacggcg
     1141 cggaagcagg tgacggtcag cgagatgtca tagctggggt cgcgcagtgt caggaagacc
     1201 actccggcgc ccggccgccg ggacagctgg gtgatctgcc cctcgaccca caccgccccg
     1261 agccggtcga tccaccctcc gatcagccgg gacacctcgc cgaccgggat cggcgcttcc
     1321 gcggacgtgt tgagagccat gaccgcgagg gtatcggcca ccaccgacag agcccgtcgt
     1381 catcgcccct acgatggggg acatgactgc aacctccgcc cgccgggtcc tgctcgctgc
     1441 cccgcgtggc tactgcgcgg gcgtcgaccg tgccgtgatc gccgtcgaaa aggccctgga
     1501 gcagtacggc gcgccgattt atgtgcgcaa ggagatcgtc cacaacaagt acgtcgtcca
     1561 gaccctcgag aaaaagggcg cgatcttcgt cgatgagacg gaggaggtgc ccgagggctc
     1621 catcgtgatc ttctcggcgc acggcgtcgc gccggtcgtc cacgaggagg ccgcgcagcg
     1681 caagctggcc accatcgacg cgacctgccc gctggtcacc aaggtccaca aggaggccgt
     1741 ccggttcgcc aaggaggact acgacatcct cctgatcggt cacgagggcc acgaggaggt
     1801 catcggtacc agcggcgagg cgccggacca catcaccctg gtcgacggcc cggacgatgt
     1861 gaagaacgtc gaggtccgcg acgagtccaa ggtcgtctgg ctgtcccaga ccaccctctc
     1921 ggtcgacgag acgatggaga ccgtggacgc gcttcaggac cgcttcccgc agctcatcag
     1981 cccgcccagc gacgacatct gctacgccac ccagaaccgc cagaccgcga tcaagcaggt
     2041 cgccgccgaa tcggacctgg tcatcgtcgt cggctccaag aactcctcca actcggtgcg
     2101 gctggtcgag gtcgcgatcg gcgccggcgc caaggacggc cacctggtcg actacgcgag
     2161 cgagatcgac gaggcctggc tggagggcgt gacgacggtc ggcgtgacct cgggcgcctc
     2221 cgtgccggac gtgctggtcg agggcgtcct ggaatggctc gccgagcgcg gcttcgggga
     2281 cgtggaggtc gtacagccca tgcaggagtc cctgacgttc tcgctgccca aggagctgcg
     2341 ccgggacctg cggtccgagg cctccgcggc cgccgggacg tccgccggga cgtctgccgc
     2401 gacgtccgcc gggacgaacg gcgcggagca gtgacgaacg aacacggcgg cggccaggcc
     2461 gcccgggtgt tcggagtgga catcggcggg tccgggatca agggcgcgcc ggtggatctg
     2521 gaccgcggcg acctggccga ggagcgccac aaggtgctca ccccgcatcc gtccacgccc
     2581 gaggcggtcg tggacggtgt ggtggaggtc gccgagcact tcggctggtc cgggcgcccg
     2641 gtcggggtga ccttccccgg cgtggtgacg gacgggacga cccgtaccgc cgcgaacgtc
     2701 gacaagagct ggataggcac cgacctggcc ggtctgctcg gcgagcggct gggcgccccg
     2761 gtcaccgtgc tgaacgacgc ggacgcggcc ggggtcgccg agatgacctt cggcgcaggc
     2821 cgcggccgcc agggcaccgt gatcgtgctc accctgggca ccggcatcgg cagcgcggtc
     2881 ttcaccggcg gtcggctggt gcccaacacc gagctgggcc atctggagct ggacggccac
     2941 gaggcggaga agcgtgcctc gaccaaggtc cgggaggacc acgacctgag ctggccgcac
     3001 tgggcgcacc gggtgcagaa gtacctggcg cacctggaga tgctgttctc gcccgagctg
     3061 ttcgtgatcg gcggcggggt gagccggaag gcgcacaagt tcctgccgct gatcgaggac
     3121 atcagggccg agatcgtccc ggctcagctc cagaacaatg cggggatcgt gggtgccgcg
     3181 atggccgcgg ctgccgctgc tgacggcgcc gccgctgccg ccccatgagg gcgatcttgc
     3241 ggacgaggac gatcagcgcg gtcagcagcg tcccggcgta gagccagccc gcgttcagcg
     3301 agagcgcggt gaacacgccc agcgcctggc ccgcgaaccc cgcgccgccg tcgttgatcg
     3361 gcagcagccc ggccgtgaag gcgatcggca ccccgatcgc ccccgggaac aggtcggcgg
     3421 gccgtaccca catcccgcag cccgcgcacg ccagcaggaa gaacaccccg tacgcggtgg
     3481 gcgacccgga gaacagcagc gcgtccacgc agccgaacgc cagcatcgcc agcgcggtca
     3541 gcagtcccgc gcccaaggcg gtgagccggg cgctgggcag ggtgaccggc cggtcgcgca
     3601 gcgtcgcggc cgcgcccagc agcccgctcc ggccgcccgg gcgtgccacc ggccgggcgc
     3661 cgcgcgccgc gccgcccgcg ctctgccttc ccccttggcc cctgcccggg tacgtgtcgt
     3721 ccgccgccgg ccggggcgag ggggcggccg cccgacgggg cgtacgtgtc ctgtagtgct
     3781 ccaccagacc aacgtaggtg ggcggagggc tgtaatccgg actgggacac gcccttcgcg
     3841 ggaccttggc agtctgttcg actgattgtc agcccgggag ggtgacggtc cgcccgggcg
     3901 ggtgaccgga ggcggccccg tagactggtg gaccggcccc cgcgggggcc ggtccctgtc
     3961 cttgcattcg atcccgctac gggaagctac gggaagtcgc caacgtgtcg ctcacgatcg
     4021 gaatcgtcgg tctgccgaat gtcggcaagt cgaccctgtt caacgccctg accaagaacg
     4081 acgtgctggc ggccaactac ccgttcgcca ccatcgagcc caacgtcggt gtcgtcggcg
     4141 tccccgaccc ccgcctcgac aagctcgccg agctgttcgg ctcggcccgc aagctccccg
     4201 ccaccgtcga cttcgtcgac atcgccggga tcgtcaaggg cgcctcggag ggcgagggcc
     4261 tgggcaacaa gttcctggcg aacatccgcg agtccgacgc gatctgccag gtcatccgcg
     4321 ccttcaagga cgagaacgtc gtccacgtcg acggcaagat ctcgcccaag agcgacatcg
     4381 agacgatcaa caccgagctg atcctggccg acctccagac catcgagaag gtgctgcccc
     4441 gcctggtcaa ggagtcccgg atccagaagg acaagcaggc ccaggtcaag gccgtcgagg
     4501 aggccaaggc catcctcgac gagggccgca ccctcttctc cgcgggcatc gtccagggca
     4561 gcgagcgcgc cgccctcctc cacgacctgc acctcctcac caccaagccg ttcctctacg
     4621 tcttcaacgt cgacgaggac gagctgaccg acgaggactt caaggccgag cagcgctccc
     4681 tcgtcgcccc cgccgaggcg atcttcctca acgccaagct cgaagccgac ctcgccgaac
     4741 tggacgacga ggaggccctc gaactcctcc agtccgtcgg ccagaccgaa cccggcctcg
     4801 ccaccctcgc ccacgtcggc ttcaacaccc tcggcctcca gacctacctc acggccggcc
     4861 ccaaggaatc ccgcgcctgg accatcaaga ggggcgccac ggcccccgag gcggccggtg
     4921 tcatccacac cgacttccag aagggcttca tcaaggccga ggtcatctcc ttcgacgacc
     4981 tggtcgaaac gggctccgtc gccgacgccc gctcggcggg caaggcgcgc atggagggca
     5041 aggactacgt gatgcgcgac ggtgacgtgg tggagttccg cttcaacgtg tgagcggttg
     5101 gactaacacc acgttgacgg cctggtaagc atgcaggtca gatggggtcg gctcgtccag
     5161 gagtcgaccc cttgcgtatc ccgtgccggg atggtgctgg gacagctgac cctgatcacg
     5221 aggccatcga gatcgtctcc gagcacggca atgccgtgcg ccgtcacagc gggatagatc
     5281 tccgccagtg ttcccagggc agagacccac tccccgaccc cggtcagcag cagcccgatc
     5341 tggcgccgga cgtccaggag caaacggttg tcctgcggga gggggtcttg gcaagcgtcg
     5401 ccaggacgag atcgtctagc tgaggggcga tctccgggca gtgggcccga agggggaact
     5461 gctccggggg catgtagccg acggttccca cgatgtcccc ggcggtggtc agacgggatc
     5521 gccgtggagg tggtctgtcc actcggtcca gttggcgcaa ccgactcggc tccccaccag
     5581 gggctggaga gtcgacgtcg atccctccga ccggtgtggt cagccccagg gtcccggtcc
     5641 tgggcgcgcg gcgggtcggc aggaagtggc gacctgtcgc ccgtccgacg aacgacgccg
     5701 acgatccggc acgcctcggg tgttgcgacg atcagtttca gccgggacgg gcggacgatc
     5761 agcgatccgg taaagggcgc gcgctcgccc agggtcaccg cgctgtcgaa gtcgtccagc
     5821 acagcgctgc cgcacgtcac gccccttccg cggtccacgg accggttcca gggccatggg
     5881 cgggccggag ccgggcagcg ggaagccctt ccgggtccag aatccgaaca atcggttcac
     5941 ctcgggcgta tcctcacgtg tgagggattg gtgaatcctt acaaagagct tatacaaggg
     6001 gggacatggg gcgaaatggg ggaagtcccc gcgttgcgcg ggccatcgta tgtctggtgc
     6061 ctgtcggctt cttcgtggcc tcggtggtgg cgacggccgc caatcgtgac ggggttcgtc
     6121 acctggccgt ggcgtccgcc gtgctggcgc tgaacctggg ccttcatctg ctgcactcca
     6181 cccgtgccgc ggtgcgccgc cgcaagccgt ggtggccgtg gtcgctcgtc gcccacgggg
     6241 gcgtgaccta cgcgccgtac gtcttcttcc aggacacgtg ggtcggcatc ccggggtcct
     6301 tcgccgccgc ggtgctgctg accacgcccg tgccgcattc gtggacggcg ttcgtcgcgc
     6361 tgtccgtgct ccaggtccct ctcgtcgtag cactgggcga gacggcgtgg cagggcctca
     6421 actcggcggt gtcgcatgtg gtgggcggtc tggcgttgtt cggcgtggtg cgcctggcag
     6481 atctggccga ggaactacag gcggcccgta cggaactggc gcagcaggcc gtcgaccgcg
     6541 aacggctgcg cttcgcgcgt gacctgcacg atctgtgtgg atactcgctg acggcggtcg
     6601 cgttacagag cgagcagatc cagtggctcg tccacagcga tccccagcgg gccgagaagg
     6661 agctggcgcg tattcaggcc ctggcgcggc atgcgctgtc ggaggtacgg gcggtgtccg
     6721 ccgggtaccg cacgctgacc ctggaaaggg aggcgcggac ggcagccgac ctgctggagt
     6781 ccctcggggt cgacgtcgac gtcgaactgg ccgggcgcct gctgccgcga ccggtcgacg
     6841 agacgctggc catcgtggtc cgggagggcg tcaccaatgc gctgcggcac agcaaggccc
     6901 ggcgctgcgc catccgcttc accgtggaca gcgggcaggc ggacggcggg tgggcgcgcc
     6961 tggacgtgac caacgacggg ctcgctccgg ggcaggtcgg ggaggccggc aggcgtctgc
     7021 tggagggggc gggcagcggt ctgcgcaatc ttcgcgagcg ggtcgcggag cggggtggcg
     7081 tgctgaccgc cgaggcggac ggcgagggcg ggtttcggct cgaggcgacc ctgccttgcg
     7141 cgagccgcga cacggcagag aacggggtct ccggccgggc gtgagactgc ggggcgcggc
     7201 ggggcggtca ggaaacggcc ctggccaggc caccgggcat ggccgcggcg ctccgcatgg
     7261 caaggcggcc ggcgaccgtg accgtggcga cggcgaccat gggggcgccg acggccagcg
     7321 cggccaacgg cccgccggcc aaggccggga ccgcggaacc ggtcaccgcg atgctgagcg
     7381 gcaccaggac cgacgcacag accagagcgg ccagcagcag tgcgaccaca caggtgagca
     7441 cggcctccca ggccagcatc cgcagtacct gggccgactg agcaccggcc aggcgcagca
     7501 gggcaaactc ccggcggcgg cccgccgtag ccatgctcag ggtgttgatg acggcgatgg
     7561 acgtgaacag gttgatcatg gtcagcaaca gcagcacgaa caggttggcc gccgcgccgg
     7621 actccgcttc tctctccgtc gccccgtcac tgatccgcgc gcccgggaaa tccgccgcca
     7681 gggtcttcag ctctcgctcg acagcgcccc gatcgtcccc gggggcggtc cgtacgagaa
     7741 cggtgtcgtc caccggggcg gccgcgtgcc gggccgccga ggcacggggc agcagcgcgt
     7801 cggcgaaacc ctggtcacgg gagtagacgg ccgcgacgcg gtacgtgtcc cggccgccgt
     7861 cgtcccagtc cactcggaca cggtcgccca ccgtgacgct caggctgcgg gccgcgccgg
     7921 cgccgagcgc cacggacgag tcgccgaggc gggcgagcga gcccgcgcgg accccgaggt
     7981 ccaggaggtc gggcaccgcc tcggcccgca tcgcgaccag gcttccgccg aagatggacg
     8041 cgtcgtcgtc ctggccggcg tccgcgcggc tcagttcgcc gtccacggtc aactgcccgg
     8101 aggccgcagc cacgccgggg agccgggcgg cccgttccgc gtagcccggc gcgatgcccg
     8161 gcccggccga ggacacgacg tgatcggcga gcagacgctg ctgctccgcc cgttgcgcgc
     8221 cctgcgacgt gaccagcggc acgcagcgca gggtgccggt gagggagagg gcgagcacga
     8281 gcggtgtcac ggtggcggcc agccgcgcgt tctgccggag gaggttacgg accgccagcg
     8341 cgccctccct gggcaggaac cacgtcaccg gggccaggaa cagggcaccg gcgacacggc
     8401 agatcagcgg cgccagcagc gccatcccga tcatcaggac gagcaccatg ctctcggtcg
     8461 tcccgccgcc accgtccagc cgaccggtcg ccacggcgcc cagacagccg cctgccccgg
     8521 cgagcacgcc catgccgagc agtacacgcc gcgggcccag cttcggcgtc ggagcggccg
     8581 actcgcggag cacgtccacc ggccgtaccc gcgaggcgcg ccgcgcggcg gcgaacgccg
     8641 cgagctgcgc cacgaccgcg gccagcacga tcgtcgccca gggcgcgacc ggccccacgg
     8701 acagggcgaa cgacgggggc aacacctccc cgttcaccag cccccgatgc aggagcatcg
     8761 ccacgccgat cccaccgggg acgccgagca gcgccgccgc cacggtcatc agcaggactt
     8821 ccaccgcgat catccggcgg atctgcccct tcgtggccgc gacggcccgc agcaggccga
     8881 tctcggtcat ccgcccggcg accgcgaacg tcagcgtgcc ggagacgacg aaacccgcca
     8941 cgaacagcga cagcaccccg aatgttccga cgagcgagga gagcgtggac gccggggacg
     9001 gcacgcccca gaactccgcc tccgcccgcc cggcaccgga ggcgaccacg agtgaccagg
     9061 catcgtcgcc gtacagcgat gtgacggcct tctccacctg ccgccggaga gccgccgtgt
     9121 ccgtcgtccc ctctgccagt acgcctacgg ctcgcacagg ctggtccgac tccgcgagcc
     9181 gctctgcctc tcgggaggta tggaacaccg cgtactggcg cgcgagtcgc cgcggtgggt
     9241 cggcgacacc cgagacctgg tacgggcgca gcccgtccgg accggccagc ctcacggtgt
     9301 cgcccacccc ggcgtcgaga cgcccggcca gggcaccgtc cagcacgacc tccgcgtcac
     9361 cggcgggcgc gcggccctgc cgcagcgcga agggcccgag ggcggcactc tcccaggagt
     9421 gccccaggaa cggtccgtcc cagggcgcct cgaccggctt gcccgacgtg tccaccgccg
     9481 tggtggggac ggacagttcg gggacggcac gctcgacgga cggcaacctc tccagcgccg
     9541 tacggagttc cccggcccgg ggcacgaacg gctgcccggc gacgaccacg tccgtgcccg
     9601 cgtaacgctc ggtgcgggat tcggcgcggg tgctcgattc cagcagcacg gcacacgccg
     9661 tcgtcatgat cagcgccagg gcgagggcca cgaaactggc tgcccagctt gccctgcggc
     9721 ccgaaagggt ccgccatgcg attcgtaaca tgggtgcctt tcgggggcgg gcgaggattt
     9781 cctcgcggtg ggcgctgaaa gcttatcgaa aattgttcgg gcgggtgcca agtcccggat
     9841 gaggtaagga gtttggccgg tttgaatacc tggagccatg cgtttttcac gggtcgactt
     9901 gtgcgttgtg tactggtgcg tttcttcctg cgtgtgaaag gtttccaggc agttcgaggc
     9961 attcgaacgc gaccgtatgg attagcgggg ggacgcaggg atgcggtacg acgcgtattg
    10021 catggtcgat cgaacgttct tcgacgcgcc gggggaagca caggaccagg agtacgcctt
    10081 cgccgccacc gaccgggaac tgcccgaggg atggcgcaag gtccgccagg acgactggct
    10141 ggtgtgcact cctgagggca cacgtcggcc ggcccagggc tggaaggtgc acgcctccgg
    10201 gtgccaggac aacgccgaga agatcctcga tgccgtccac aacttctgcg tgccccgggg
    10261 aatcccgttc aaattcctgc gcggccagca catcctccag ctgcggaaca tgaagtacgc
    10321 gtcccggggc gccagcggca aactggtcac gatctacccg gcggacgagg cggagctgcg
    10381 cgaggtcctc gaaggcgtcg aggccctcgt cggcggcgag cccggcccgt acatcctcag
    10441 cgatctgcgg tggcaccagg gcccgttgta cgtgcgctac ggcggcttcg tcgagcggca
    10501 cgtcgtctcg gagaagggcg tgctggagcc cgccgtcgag cggcccgacg gcacgctcgt
    10561 ccccgatcgc cgcctgcccg gcttccacgt ccccgactgg gtgacgctcc cggagttcct
    10621 ccagccgcac gtcgaggcgc ggcgtgccga gtccctggcc ggtctgccgt acgcagtgcg
    10681 ccgcccggtg cacttctcca acggaggagg cgtgtacatc gccgaggaca cccgcaccgg
    10741 caaggaggtg atcctcaagg aggcccgccc gtacgccggt ctgacggccg acggaagaga
    10801 cgccgtgacc cgcctccagt gggagcggga cgtcctggaa cggctcgccg gactcgacgc
    10861 ggttcccgcg gtggtcgact acttcaccgt gggggatcac cacttcctcg cccaggaact
    10921 cgtcgggggt cagccgctca gcaagttctt cggcctgaag tacccggaga ccggcccgcg
    10981 ggccgacccc gaggagatcg ccggctacac ggagtgggcg atgggtgtct gccgtgccgt
    11041 ggagcgtgcg gtcgtctcgg tgcacgagcg cgggatcgtg ttcggcgacc tgcaccccta
    11101 caacatcatg gtcggggacg acggccgcat cgggctgatc gacttcgagg tcgcggcacc
    11161 ggtcgagtcc ggggcggtac ggatgctcgg ccaccccgcg tacgcggcgc ccggcgaccg
    11221 caaggggttc gccgcggaca cgtacgccct ggcgtgcatc aagctcgcgg tgttcctgcc
    11281 gctgaccgct ctgctgaggc tggacctgca caaggcggcg gaactggccg acgagatcgc
    11341 cgcacggttc cccgtgccgc gggagttcct ggactcggcg gtgcgggaga ttctcggcga
    11401 gagcaccggg gcgagcggtg gcccggccgg gagcgggcct gcggtggagc gtggccagac
    11461 ggacgggagg ggcggtgccg tccgcgacag actccggggg cgggacggcc ggccgccccg
    11521 ccccgggccc gatcgccgga gctggcccgc cgtgcgcggg tcgctggccg gcgcgatcct
    11581 ggcgagtgcc actcccggcc gtgacgaccg tctgtttccc ggagacatag cccagttcag
    11641 caccggcgcg ctcaacctgg cccacggcgg cgcgggcgtc ctgtacgccc tggacgtcac
    11701 gggcgcgggc cgctaccccg agcacgaaca gtggctgctg gagcggtcgt tgcgccgcga
    11761 gcagcgggcc aggatcgggt tctacgacgg gctgcacggg gtggcctacg ccctcgacca
    11821 cctcggccac cacgacgacg cccggcaggt cctcgaccgt tgcatgggcg agaagtggca
    11881 gcgcctcggc acggacctgt acagcggcct ggcgggagtc ggcctcaatc tgctccactt
    11941 cgcggagagg acgggcgaca gcggtctgcg ggtggcggcc ctggaggtgg ccggcaccgt
    12001 ggcggagcgg ctcggctccg ataccgacgt acccgaagtg agcggcggcc agcaccccaa
    12061 agcgggcctc atgcacggat cgtcgggccc ggccctgctc ttcctgcgct gctacgaggc
    12121 caccggcgac cacgtcttcc tggacctcgc ggcgaccgcg ctgcgccagg acctgcgccg
    12181 ctgcctcacc cgggaggatg gtgccctgca cgtcaacgag ggctggcgct cgctgccgta
    12241 tctcgccgag ggcagcgcgg gtgtcgccat ggtgctggac ctgtatctcg cccatcgcga
    12301 cgacgaccgc ttccgggcgg cggcggcagg cgccctgatc tcgtccagct cccagttcta
    12361 cgtccagtcc ggactcttca acggccgggc gggcatcatc aaccacctcg gggccgtgtc
    12421 accggagcgt acgccggcag ccgatccgct cctcgccgca cagatcgacg ccctgtcctg
    12481 gcacgcactg gagtaccagg gagaactggc cttcccgggg gaacagttgc tcaggctgtc
    12541 gatggacctg gcgaccggat ccgccggtgt gctgctggcc ctcggtgccg ctctgcacac
    12601 cgggccggtc cacctgccct tcctcggccg gcaccggcct gcctgacctc acagatctgc
    12661 ccgccgatca cggcgggcgc ccgcaccgcg ggcacgcgca tccgcgccag aaggaggtga
    12721 ttcccatgtc cctgctcgaa cttcaggaga tggagctgcc caccgagtcc tcggaggaga
    12781 cggttctcgg cagcggtagg agccagcact gctcggacgc cagctgggtc ttctgctgac
    12841 ccgctcacgg gccgtgaccg gctcacagta cgaccgacac gtaccgatcg atcgaagaga
    12901 gaggaaacag catgtccctg ctcgaacttc aggagatgga actgccgacc gagtcctcgg
    12961 aggagacggt tctcggcagc ggtaggagcc agcactgctc ggacgccagc tgggtcttct
    13021 gctgagtcca gcgccccggg cctgcacaca gcggcaggct gaaggcacct gacacggctt
    13081 ccacgccgtg agcggacccg gtcggcgggt ggggcaatca cccgccggcc ggtccgtgtt
    13141 tcttcccggc cgcccgtcgg acctcgtgca gggagcagtt ccagtgaccg tgcgtcagcc
    13201 gttggagagc gcggcccggc tcccgggccg tgcggcggac cggatacttc tgtgtaccac
    13261 gcgcgagggc ggcgtctgga cgaccgttct ggtcatcacg gccgtcttct cgaccacggc
    13321 ccagatcctg ttcccggcct tcctcggcaa ggccctggac tcggcgctcg acggtggcgg
    13381 cggggcgagc gggtggacga tcggctgcct cttggccgtc accgccatgg ccgcggccga
    13441 cgcgctgttc gagctggccg ccggggccgg cgccgcctgt ggaaccgctc tgctgcgacg
    13501 ttcgatgctc gcgacgctgc tctcgtggtc cgggcccggc gggccccgca ccaccgcagg
    13561 cgacatggtg agccggctgg tcggtgccgc ggccgaggcg ggcggggtcg ccgccgtact
    13621 cgtccgcgcg gcgctgtcga tcgtgccggc cgtcggcagt gtcgtcgccc tcttcgtcat
    13681 cgacccctgg ctcgcaggca ccttcctgct gggcctgccg gcggtcgtcc tcctgctgcg
    13741 cgcgttcacc cgccacatct ccgacgtgtc cgtccggtac caggagacac aagggcgcct
    13801 cgcgaccgcc ctgctcgagg ccctcaccgg acgccgcacc atcgccgccg cgggcacggc
    13861 cgacgccgag gtccggcggg tgctgcgcgc gctgcccgag ctcaaccggc tgggacacgg
    13921 catgtggcag gcccagaccc aggcggccgg ccggtccgcg ctgctcacac cgctgctcga
    13981 gatcgcggtc ctgtccgtgg ccggtttcgc ccttgccgcc ggccgtatca ccgtgggtga
    14041 gatgctggcc gccgcgcagt acgtcgccat cggcagtggc ctcggtatga cgacgatgct
    14101 gctcggcagg ctggccaggg cgcgtgcggc tgcggagcgg gtgcacgggg cgctggcaca
    14161 gcccgtcctg gagtacgggg accgacggct gccccccggc ccgggccacc tggagctgcg
    14221 ggccgtgcag gtgaccgccg ggggcgaacg tgtcctggac ggcgtcgatc tgacggttcc
    14281 cggaggcacg tgcacggcgc tcgtgggtgc gtcgggttct gggaagtccc tgctggccgc
    14341 cgtggccggg cggctgacgg acccggacgc cggggcggtc gtcctcgacg gcatgccctt
    14401 ggggcagctg acccaccgcg acctgcgatc cgccgtcggc tacgccttcg agcggccggt
    14461 gctcttcgga gagacgctgg gcgacgccat cgcccgcggt accggccgga cggccgggga
    14521 cgtaccggaa gagcggatcg tggtggccgc gcgggccgcg gatgtcgacg gattcgtccg
    14581 gcggctcccg gacgagtacc ggaccccgtt gggggaggcg tccctgtccg gaggcgaggt
    14641 gcaacgcatc gggctggccc gggcgttcgt gcactccggc cgactgctga tccttgacga
    14701 cgccacgtcg agcctggaca cggtcaccga gcaccgcatc agccaggtcc tcaccggagc
    14761 cttgcgcgac cggacccgga tcgtcgtcgc ccaccgcgcg gccacggccg cccgcgcgga
    14821 cagcgtcgta tggctcgacg gcggacgggt gcggcgcgtc ggtccccacc acgaactgtg
    14881 gcgcacggaa ccggagtacc ggcgggtgtt ccgcggtgcc gaggctgtcg aggaggaacc
    14941 gtcgtgaggg ccggatcacc aggggagccc atgctccccg tgctcatcgc accgctcagg
    15001 gcgcggcccg accgtctgct cgcactggtc ctctggtcct tggtcgaggc ggtccccgcg
    15061 ctgctcgccg gccatctcgt ggctcgggca gtcgaccagg ggttcgcggc cggaaggccg
    15121 ctcatcgggc tggcctggct cgccttgatg ggcctcggcg tcttcgccgg agcatgggga
    15181 acgcggcagg cgtatccgct cttggccgag gtggtcgagc ccttccggga cgacctcgtg
    15241 cgcaaggtgg ctgaggactc cctgcggcag gcagtggcgg gccgggccgt cgacgcttcg
    15301 ggcgtctccc ggctgactct ccaggtcgag atggtgcgcg aggcctacgc gggcgtgctg
    15361 atggtcgtcc gggggttcct cctcacggtg ggcggggcac tgctcggcat ggtgttcctc
    15421 gcaccgctga tcctgctgct cgttgtaccg ccgctgctgg tggggctcgg tctcttcctg
    15481 gtactgctgc gccggatggc caccgcgcag cgcgacgtca tcgtcgcgga cgaacgggtc
    15541 gcggaggcgg ccggcgccgc gtgcgcggcc gacagggaca tcgtggcctg cggtgcgaag
    15601 gacggcgtac gggcggacct cgtcgagcac atcgacgcac aggccgccgc cgcccggcga
    15661 ctcgccgtcc tgatgccggc acgtgttctg tgcctggccg tcgccggctg gcttcccttg
    15721 ctcctgttgc tgacggcggc cggtcggctg gtcgacggcg gactgtccgc cggcgccgtg
    15781 ctgggcgcgg cgacgtatgt gacaggcgga ctgcaaccgg cggtccgttc cctcatccag
    15841 ggcttgggcg gcagtggact ccgcctggtg gtggcactgc gccgcatcca cgaggcacag
    15901 gggccgacgg cttcgccggc ggatccggcg cggggtgcgg atccggtgcc gggcgcgacc
    15961 tcccagccgc ccctgacgac ggcccccacg gcctacgacg tcgaactcac cgccgtcacc
    16021 ttcgcctacg gaccgcaggc ggccccggtg ttccgggagc tggatctcac gctgtccgag
    16081 ggcggacatc tcgcggtcgt cgggccgagc ggcatcggca agtccacgct ggccggcctg
    16141 atcgggggga ccctggagcc ggacagcggc ctgatccggc tcgggggccg accgcccggt
    16201 gccctgcccg gggccgacct gtccgccctg cgggtcgtcg ttccccaaga ggcgtacgtg
    16261 ttctcgggcg acctctgcga gaacctgcgc tacctgtgcc ccgacgcctc cgagcacgag
    16321 gtggtggcag ccgtggagtc cgtgggcgcc ggaccgctcg tggcgcggct cggtgggatc
    16381 ggtgcggtga tcgatcccgc cgcactctcg tccggcgagc gccagcagat cgcgctggtc
    16441 cgcgcctacc tgtccccggc ccccctcgtc ctgctggacg aggcgacctg tcatctcgac
    16501 cccgccgccg aggcacgggc ggaggaggcg ttcgcgcggc ggcccggctc cctggtcgtg
    16561 atcgctcacc gaatcagctc cgcgctgcgt gcccggcagg tcctcgtcct ggacggcagc
    16621 cgggttgtga gcggcgcaca cggcgaggtc ctggaacggt cgccgctcta ccgggatctg
    16681 gtggggctgt ggagcgagga cgggcaggag ccgcttgcgg ggagcgacga ggcgtccccg
    16741 accgtcggcg ggatcgtcag agccaccccg cctcggtcgc gatcctgatc gcgtccacgc
    16801 ggctgcgggc ctgcgtcttc gccacggcgg aggccaggtg gttgcgtacg gttccgaccg
    16861 agatgtagag ctgcgcggcc acgtcccggg ccgacgcccc ctgtgcggtg agccgcagga
    16921 ccgacacctc acgcggggtc agcggatttt cggtcgccgt cgcggccgcg agcaccagct
    16981 cgggatcgac gacccgacgc ccctgcgcca cctggcggat gtcctccgcg agccgggccg
    17041 tcggggcgtc cttgcggacg aagccgacga cttgggccga cagcgcgcga cgcacgtgtt
    17101 ccggccgtgc cacgctcgtc aggacgagtg tgcggcacga gggtaaccgg gcatgaagtt
    17161 ccacggcggc cgtgatcccg tccgtaccgg gcaggtcgat gtcgaggacc gccacgtccg
    17221 gcggtgtgcg cagggcggtc gggacgatga ggtctccgtg gtcgaccgcc gcgacgacct
    17281 cgaggtcggg ttcctgggac aacagcgcgg tcaacgcctg acggatcagc ggggcgtcct
    17341 cggccaggag cacgcgtatg cgatcgccgc tcccgggtct gcccccgcct gttctctccg
    17401 cgctttcttc cacgctaggc ccccagccga tcgctgcacg ttcgaaccaa tgacatgcga
    17461 cgtcgatcat gtgagcaaga agcaaaccgg ccacgaaata caccctcccg gagtagctct
    17521 tcgcaccggg cccggccggc acaccacagg gcaaggagcc cgctctttcg tagtcagcga
    17581 tgcccccatg aaccgcgtac cgcgacgcga tgcgcgggtg aggtcggccc cggtgaagtc
    17641 cgcgccctgc gcgtccgagc ggtagagatc ggccccccga tggcgtcaac gggcgtcagc
    17701 gcttcggttt gcccttggtg tacagccagg tgtcgaagag cttgctcagg tccttgccgg
    17761 acaggcgctc ggacagggcg atgaattggc gcgtgtcggc gttgccgtgg cggtggtccc
    17821 gtggccaggt gcggaggatg cggaagaagg tgcggtcgcc gacggcgcgg cggagttggt
    17881 ggagggccat cgcgccacgg ccgtagacgg gtgggtcgga gatgtggccg ggggagggtg
    17941 gggtggcggg cgggaaggac caaatgccct tgctctcgtc gtccgtgccg tcgtagaagg
    18001 cgtcgaaggt ctgctgggcg gtgcggccgc ggtgctgttc ggtccagagc cattcggcgt
    18061 aggtggcgaa gccctcgttg agccacatgt ccttccaggc gcgcggggtg accgagttgc
    18121 cgaaccactg gtgggcgagt tcgtggacga tcaggcgctc gtcgggggcg gcggcgaagt
    18181 agggcctggt ctgggtttcc agggcgtagc cgagctcggg gaggcggtcg acgatggcgc
    18241 cggtggaggc gaaggggtag gggccgaagg tgcggcgttc ccatgcggtg atcttggcga
    18301 tctggtcggg gacgtcgcgg gaggcatcgg cctcctcggg gtcgatggcg acgtactggg
    18361 ggaggccgtg ggcggtggtg gtgtggatgt cgaagtggcc gatggcgacg gtggccaggt
    18421 aggaggccat ggggtcgtgg gtgcgccagt ggtgggtggt gcggccgttg tgggtgtcgc
    18481 ggcgggtgag ttcgccgttg gagacggccg cgtagccccg ggggacggtg accgtgatgt
    18541 cgtacgtggc cttgtcggag gggtggttgt tgccggggaa ccaggtcatg gagccggtcg
    18601 gctcgccgag tcctacggcg ccgtcggtgg tccggagcca gccctcgcgg gagccgtccg
    18661 ggtcggtgat ggccttcggc ttgccgtcgt agacgacggt ggtcgtgaag gtgcggccct
    18721 cggggagggc ggcggcgggg gtgagggtca gctcggtgcc gtcgcgggtg gcgcgggcgg
    18781 agcggccgtt cacggtggtc tcgcggacgt acagtccggc caggtcgagg tggaatgagc
    18841 tgagggcgcg ggtggcgcgg gcggtgatcc gggcggtgcc gcgcagccgg tgggtgccgg
    18901 gcgtgtagtc gagcgcgagg cggtagtggg tgacgtcgta gccgccgttg ccgaggcggg
    18961 ggaagagggg gtcgcccttg cccgccgcgc ccggggccgg gggcgcctcg tgggacggtc
    19021 cggtgcagga cgtgctcagc agcaggagcg gggccaggag cagggcgccg gggaggaggc
    19081 gtgcgggtcg ctggggcacg gttctcctcg ggtgggcggc ctgcggactc atgatcacca
    19141 tcaaaccggg tgaaccggat gcctgtcgat ataaacgtct ccgaactgga gttcaccact
    19201 tctagtgaag ctttggccgt cagttgctat cggcaaccga cggttgtcaa gctgttgctg
    19261 actgtcaacc actgggagtg cacgtggcct ttggtgacca gcccgcatac ctccgtgtcg
    19321 ccgacgacct ccggaagaag atcgtcgcgg gcgatctgcc accgcacgcc cgcctcccct
    19381 cccaggcgcg gatccgcgag gagtacgggg tctccgacac cgtcgccctc gaagcccgca
    19441 aggtgctcat ggccgagggc ctggtcgagg gccgctccgg gtcgggtacg tacgtccgtg
    19501 agcagcccgt cccgcgccgt ctggtgcgca ccggctatca cccccggggc gagtccagcc
    19561 cgttccggca ggagcagggt gacgaccggg tcagcggcac ctgggactgc gggagcgaac
    19621 aggaggaggc gagcccggag atcgccgagc ggctgcgggt cgagccgggc gagcgcgtca
    19681 tgcgcacccg gtatctgttc cgggcggcgg gcgagccggt gatgctctcc acgtcctggg
    19741 agccgctcgc cgtcaccggc cgcacgcccg tgatgctgcc cgaggagggg ccgttggccg
    19801 ggcgcggggt ggtcgaccgg atggcggccg tcgacgtcgt ggtggacaac gtggcggagg
    19861 aggtcggggc gcgtcccggc ctcgccgagg aggtgctggc gctcggcggg gtgccgggcc
    19921 atgtggtgct cgtgatctcc cgtacgtact tcgcgggcgg tcggccggtc gagacggcgg
    19981 acgtggtgac gctggccgag cgctaccggg tggcgtacca cctgccggtg aagtgaggcg
    20041 tggagcggac ttggccgggg tgggcgtctc cgtctgcggc ggttctccgg ccccggctgc
    20101 gtgaccgcga gtttacgtcc gcctcttcgc cgtaacggac cggcaacgcc cgctcgcggc
    20161 ctgccgacat gtcaccggcc tagcttcctc tggcgtaccg ctcacgcgcc gaacgacagg
    20221 ggaagccgcc atgacggaca cggtcacacc cgaccagacg cagacgggct cgacagcggc
    20281 ccgcgcgccg cggcgcagtt atgcccggct cgccgccgac gaaagccggg aggactactc
    20341 gctgcgctac gcgccgcact cctaccgccg ttggtcgccg accatggtcg cgtcgacggc
    20401 gctcggcggc atcgcctatc tcgccgactt cgcgatcggc gcgtccatcg tcttcacgta
    20461 cggcttcacc agcggtctcg cctcgatcct caccgcggcg acgatcatct tcctgaccgg
    20521 tatcccgatc gcgcgcgcct gtgcgactta cgggctggac atggatctga tcacccgtgg
    20581 cgccgggttc ggctacttcg gatcgactct gacgtcgctc atctacgcga gcttcacctt
    20641 catcttcttc gcgctggagg gctcgatcat ggcgcaggcc atgcagcagg ccctccacat
    20701 cccgctcccc atcgggtatc tgatcaccac tctgatcgtc atccccatcg tcttccgcgg
    20761 gatgggcgcg ctggccaagg tgcaggcgtg gacgcagccg ctgtggctga tcgggctggt
    20821 gctgccgttc gtggtgctgg ccttcgaacg gccggacgcc tgggcctcgt tcgcctcctt
    20881 cggcggtacg gagggggcgg ggtccgggtt cgactggatc gggtacgggc tcggcaccgg
    20941 cgtggcgctc tcgctgatcg cccagatcgg tgagcaggcc gactatctgc gcttcatgcc
    21001 cgccaagacc gagcagaacc ggcggcgctg gaatctggcg gtgctggccg ccgggcccgg
    21061 ctgggtggtg atcggcgcgg ccaagcagct cggcggcgcg ttcctggcct tcgtggcgct
    21121 cggcgcggtc ggcacgaccc atgccctgga gccgatcgcc ccgcagatcg aggcgttgaa
    21181 gccctggctc ggctcggtcg cgctgccggc cgccgcgctg ttcgtcgtgg tctcccagat
    21241 caagatcaac gtgaccaacg cctacagcgg ctcgctgtcc tggtccaact tcttctcccg
    21301 ggtgacccat cgtcaccccg gccgggtctg gtacatcttc ctcaacctcg ccatcgcgct
    21361 ggcgctgatg gagatgaaca tgttcgcggc gctcaacaag ctgctgggct tctactccaa
    21421 cgtcggcatc gcctggatcg cggcggtcac cgccgatctg gtgatcaaca agccgctggg
    21481 gctgagcccg aagtacatcg agttcaagcg cgcgtacctg tacgcggtga acccggcggg
    21541 gttcggtgcg atggtgatcg cctcggtggt ttcgatcatc gccttcttcg gagtgttcgg
    21601 tgaggtggcc gaggcgttct ccaccttcat cgcctgcggt ctggcgctgg tgctcagccc
    21661 gctgctggcc tggctcaccc gggggcgcta ctacctggcc cggccgaacc cggtgaacgg
    21721 gccgggggtg gaggtgccgg acgtcaccgc cgtccacacc tgcgcggtgt gcgagacggc
    21781 gtacgagctg ccggacatcg ccgactgtcc ggtgcgggcc ggggcggtgt gctcgctgtg
    21841 ctgctcgctg gacgccgagt gcggtgacgc ctgccgcaag ggccccaagg gttcgcacgg
    21901 cgcggccccc gtcctgttgc cggtgccgac cgtacgagcg agcggggcgc gacgagcgag
    21961 cggggcgcga cgagcgagcg gggcgcgcgc gagcgacggg taaggctgcg caacagcgta
    22021 agagagccga ggcgggtaaa aggccggtaa tttattcggc tggtcttttc tccgactcgc
    22081 ggccaacttg agccggattt gagcttgttg gttcatgggc ggcgccgtgt tccccgtccc
    22141 tcgctattca aaacccatgc gccggaatcg atgcccgcgg cttgtccaat cgggcgcatt
    22201 cggcgatatc acagcggaat ggcggcgccg gtgagggcgc cgcctccgcg ccgcctccgt
    22261 gctggcccgt accgtctggc cagcgccttc gtgtgacgcc gaacgccgtg gcgggtccgt
    22321 agaggttttg cgaaggccct tcccgtagcg gcccgcatgc gctccgcaag acccccgccg
    22381 gattggtgtg ttgcatagat cacacgcgat gtccgatagc tcagatcggc ctcaagcccg
    22441 taaagcgcac ccttatttcg cttgtacgat ggcgcggttt gcatcaggtc tggggggcga
    22501 aaggagcgtg aggggcgttg accacggagc agggttccca ctcgcattac aaacggtcac
    22561 tcggcacggt ggccctcacc gcggtgggcc tcggttcgat catcggctcc ggctggctgt
    22621 tcggcgccgc gcgggccgcg gcgctg
//
