LOCUS       NZ_CP058693            22566 bp    DNA     linear   CON 08-SEP-2024
DEFINITION  Streptomyces sp. Rer75 chromosome.
ACCESSION   NZ_CP058693
VERSION     NZ_CP058693.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Rer75
  ORGANISM  Streptomyces sp. Rer75
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Genome analysis of Streptomyces sp. Rer75
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-JUL-2020) College of Pharmacy, Henan University of
            Chinese Medicine, Jinshui East Road No. 156, Zhengzhou, Henan
            450046, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. Canu V1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 76.63x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013414305.1-RS_2024_09_08
            Annotation Date                   :: 09/08/2024 05:25:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,857
            CDSs (total)                      :: 8,765
            Genes (coding)                    :: 8,460
            CDSs (with protein)               :: 8,460
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 305
            CDSs (without protein)            :: 305
            Pseudo Genes (ambiguous residues) :: 0 of 305
            Pseudo Genes (frameshifted)       :: 145 of 305
            Pseudo Genes (incomplete)         :: 204 of 305
            Pseudo Genes (internal stop)      :: 20 of 305
            Pseudo Genes (multiple problems)  :: 62 of 305
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:27:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5551728
            Orig. end                         :: 5574294
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058693.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22566
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="21"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22566
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22566
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12566](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12566)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(575..589)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.13"
                     /tool="antismash"
     gene            1433..2182
                     /locus_tag="HYQ63_RS23770"
                     /old_locus_tag="HYQ63_23770"
     CDS             1433..2182
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035112.1"
                     /locus_tag="HYQ63_RS23770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23770"
                     /product="response regulator transcription factor"
                     /protein_id="WP_179935772.1"
                     /transl_table=11
                     /translation="MHETSRILVVDDEPSVREAIGRALRFEGYEVDTAGDGVAALRRIE
                     EEPPDLVLLEVMLPGLDGLAVARRLRASGRTVPIMMVTGRDSVGDRIVGLDNGADDYLT
                     KPYASEELLARVRALLRRGRTVPAAPPVCPPSPWQAPARPEPGARLAFADVTLDTLTRQ
                     VTRSGRPLDLTKTEFALLKLFLSRPRQVLSRAAILRDVWGFDFEPSSNTLDVYVMYLRR
                     KTEAGGEPRVVHTVRGVGYVLRTVPGD"
     misc_feature    1985..1987
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2199..4571
                     /locus_tag="HYQ63_RS23775"
                     /old_locus_tag="HYQ63_23775"
     CDS             2199..4571
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655308.1"
                     /locus_tag="HYQ63_RS23775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23775"
                     /product="sensor histidine kinase"
                     /protein_id="WP_257232041.1"
                     /transl_table=11
                     /translation="MTSAEGASAVETGAGEREVDLAAERYGVGVRATVISLCGVFGIFT
                     VPTGRLPVTVLLVVVTTAACAVRWWGLRRLPAGVRMGLDATAVAVPGLGQPLMGPQGVN
                     IWVMVILGIAVITFQYEWATRPAIGLGLAALTLATYGVGYGLAAPALGPSPFWVAARQT
                     AECALARVSYLIVRAKARAADRATEREAAGRREASVAAARRAAGRAYLATLHDTASATL
                     LMVSLGGARDWSWLPRRAHRDLEALSAVPGHEAGRVDLAELLGEVAKGAAEPDAVRAVR
                     VSARIDGPLMMPAGAALAILHGVGAALDNVVRHAEVDEADLRAGRDASGTVTVELTDRG
                     RGFLPAAVSVQRRGISGSVVGRMEAIGGRGEVDSRPGEGTRVRWEWPTTPTEATPPGEA
                     PAAAAPPERVTPEPGPDGRTAFRQIHGRLVRGVRWALLLVALTVQVGLCLPQFLAHLGS
                     YHPPSAPVVAYGVLGAVAVFTAGLLASGRDVSGWPRWCGVGLVLGASALCAVTVGADQR
                     LREGDWAFGLVGWHGLYLLFGLSVTAIGVFLGAQIVLTAIPVALTGMPDVARLATMGMF
                     ALSVCGFQFTVGVLARLLRRSAETAGSAAAREEELRTREAIEERMHLDHEKRYATLLRT
                     TVPLLAGLAHGSLDPRDGQVRHRCALEAARMRRLFAEADEVPDRLVHELRACIDVAERA
                     GVTVGLAVRGARRDVPQDIRRKLADPVAAVLAAGPAEARVTVVRTGSRVRVSVVGDGTA
                     EPDGVAVKETSPVAVSRTADGEKVWVEAVWEPAPAAG"
     misc_feature    2349..2351
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4618..5271
                     /locus_tag="HYQ63_RS23780"
                     /old_locus_tag="HYQ63_23780"
     CDS             4618..5271
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716094.1"
                     /locus_tag="HYQ63_RS23780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23780"
                     /product="response regulator transcription factor"
                     /protein_id="WP_179940431.1"
                     /transl_table=11
                     /translation="MPTETVSVALIDDHPAIRAGVEAWYASSDQPIKVIAAGETAATAW
                     TPPGDGADVVVFDLQLSDAGPAFGELRRLVDAGRQVVVYTMRDEEQTALTCLDLGAATY
                     LTKTEGSRHLVAATLAAARQHPYTPPALAGALGTNARSDRPRLSQREEDVLIEWFQSES
                     KELVAQRLNIKVRTVNTYLDRVRIKYANAGRPARTKAGLVARAIQDGLVAVEDL"
     gene            complement(5177..7036)
                     /locus_tag="HYQ63_RS23785"
                     /old_locus_tag="HYQ63_23785"
     CDS             complement(5177..7036)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="HYQ63_RS23785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23785"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_179935773.1"
                     /transl_table=11
                     /translation="MPPTGAHRKPSRTGRHPLRPVLAAHRRDLALLIGWSLLGTAPALL
                     SGRLVATALDRGFLADDARTGLVTLAVYGLVMVAGAYGTRQAVPRMATVVEAMRDHLVT
                     VTVRGGLHGAVADGQPPRTSAVSRITDQTERARQLLSNLLMTACTSGFTFLAAVAGLTA
                     LAPAVGLLLLPVLCVTGLALLRLSRTWRRRYDASLDSEETVAEESGRVIGALRDVLACG
                     AVGRATADLEDRLRANARAAEAVATVGGVRTGLIGLAARTPLVLLLLLGPRLVAGDALT
                     PGELLGAATYLVTSLEPALRALVHSVGNMGLELATVLGRLARHTAPAPPDPGGPHTTDR
                     YDLALEEVTFRYGPHSAPVLDRATVTVPYGQHLTLVGASGIGKSTLVGVLAGLERPERG
                     TVRLGGASLPTLRTDWLRSAIALVPQEAYVFAGTLRENLTYLHPGVEQRRLDHAVSVLG
                     LTGLVREHGGYDGTPLRPTALSAGQRQLITLARVYLSPARVVILDEATCHLDPVAEERV
                     ERAFRSREGTLIVIAHRISSALRADRVLVLDTAGLHGGTHASLVRDCATYANLVGHWRG
                     DDRGSPGLTDPRLTDPRRPPARPGWPAPPDLLSSAPGAPRSRT"
     gene            complement(7042..8835)
                     /locus_tag="HYQ63_RS23790"
                     /old_locus_tag="HYQ63_23790"
     CDS             complement(7042..8835)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="HYQ63_RS23790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23790"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_179935774.1"
                     /transl_table=11
                     /translation="MPSSDRIVRDALRASGAHGPGLLAVAVLDPATRLLLPAALAGALD
                     AAIGKEPQGRAVVPVIAVFALLALTTATEAAREILEKRSAARATLALRRRVLHQVLALG
                     RAGQDAFGPGDVLSRLLGSSAGTAPAAQYLVGLAASLLTSLGGLVGLFLIDVRLGLFFL
                     LGAPLMWWLGRWLMSRVGSATHTYQEIHGELAERFVDALRGARTIRAAGTAEQEAARVL
                     APLPRLRAAGLDFWQTQRKATWQAGLVTPLVQIGVLAVAGLGVLHGRITPGELLASQAY
                     LGYALGLLKQTAMLAQLARCRGSAARIGELLDVPAPSAGTRPLPDGPGRLTLRGVRVAR
                     SGTPLLNGVDLDVPAGHSVAVIGASGAGKSTLTEIAGGLLAPDSGDVLLDGVPLRDIRP
                     DELRRAVGYAFERPTLLGDTLGDALAYADHPPPPHRVASALRAGSADAFVTRLPDGLAT
                     PLHRLRLSGGELQRLGLARVAARQARLVVLDDATSSVDTATESEITAALDRVLFGTTRL
                     IVAHRMSTAAGADLVAWLDRGTLRALAPHKALLKDPEYRAVFQLPDPRPAPADPGPAPD
                     ETLRLRLPGAEHPTMQLRLGW"
     gene            complement(8875..10014)
                     /locus_tag="HYQ63_RS23795"
                     /old_locus_tag="HYQ63_23795"
     CDS             complement(8875..10014)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012517.5"
                     /locus_tag="HYQ63_RS23795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23795"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_179935775.1"
                     /transl_table=11
                     /translation="MTAADPVREPVRFGTLISANRHEGQSDADVLARSVAVARKTEELG
                     LDDVWVTEHHFLPSVVAPSAMSFASFLLGTTSRVRVGTAVALLPLHSPVHIAEQAAFMD
                     HVGQGRFVLGVGRGLPVVEYEVIGGGPAHWKDGLGEALDLTLRAWTGKVSADSALHRFR
                     PVTVSPTPRTPEGPPVYVAASSPDSVALAAERGIPMLLYFDKDAAAKADMIARHTALAD
                     EHGHRDPAAGDHAFAVYAQVTDTEEQAHALMRDRAKRSLRANQDSQIIIGDGDGPRQAT
                     PGEDEETVDRMARKMLAEHPVGTVDTCVERLVHAITTCGARRVLCQVEVSGERHGSLRN
                     LERLTTEVFPEVRRRVGPPPIGPAGPVGPPPVGTPPPAA"
     gene            complement(10001..10423)
                     /locus_tag="HYQ63_RS23800"
                     /old_locus_tag="HYQ63_23800"
     CDS             complement(10001..10423)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014140854.1"
                     /locus_tag="HYQ63_RS23800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23800"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_179935776.1"
                     /sec_met_domain="PF13471 (E-value: 2.1e-26, bitscore: 91.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMPVTLESRTRVPWHHRAAARFAVGAARLLVRLRPRRLRRVLES
                     VRRGARPADAATAGAARAAVVAVSRRCAAQQCLQRSVATALLCRMWGVWPDWCTGVRTQ
                     PFRAHAWVEADGQAVGEREDVTLYRTMMEVRAHDRR"
     gene            complement(10420..10677)
                     /locus_tag="HYQ63_RS23805"
                     /old_locus_tag="HYQ63_23805"
     CDS             complement(10420..10677)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056407.1"
                     /locus_tag="HYQ63_RS23805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23805"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_179935777.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.2e-24,
                     bitscore: 84.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 3.2e-08,
                     bitscore: 32.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.7e-14, bitscore: 51.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIALAPHVTASETEDGLVLLDEEQGRYWQLNRTASLVLRLLLEG
                     NEVPEVVDTLRARTPEGSERAAEDVEKLLASLRRSKLVTA"
     aSDomain        complement(10426..10677)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HYQ63_RS23805_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="7.10E-27"
                     /identifier="RREFam002.1"
                     /label="HYQ63_RS23805"
                     /locus_tag="HYQ63_RS23805"
                     /protein_end="84"
                     /protein_start="0"
                     /score="84.3"
                     /tool="antismash"
                     /translation="MTIALAPHVTASETEDGLVLLDEEQGRYWQLNRTASLVLRLLLEG
                     NEVPEVVDTLRARTPEGSERAAEDVEKLLASLRRSKLVT"
     gene            complement(10674..12566)
                     /locus_tag="HYQ63_RS23810"
                     /old_locus_tag="HYQ63_23810"
     CDS             complement(10674..12566)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="HYQ63_RS23810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23810"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_179935778.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.4e-38, bitscore:
                     132.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFVILPDSPAGSRIADRITAAAAEEEAAAGRPPLSVLPHASGRP
                     WVVGRWRADEIVQATAGARRVALLGPSGATPAMLTAALADARRPADFDRLARTTAGNFH
                     LVAAVDGVVRAQGSAGASCQIYTAAVEGVTVAADRPDTLAALTGAGVAEQRLADRLLHA
                     APPGPLEEGSLWEGVERLPADHYLTLAPDGGSGTARWWTVPEPEVPLAEGAEAIREALR
                     DAVRARMSASWGDGGRLSADLSGGMDSTSVCFLAASLTPDLLTYRFEAADAANDDEVWA
                     ARAARAMGDAEHRIIPREEMPLNFAGLLEPDPDLEGPFPWIRTRTRLADQARHLAAGGS
                     RGHLSGHNGDELFYAAPAYDHTLVRSHPLRAAHIIRVGRAHRRWKLAPMLRALADNQSY
                     GSWIAAQARRLDTPPPPPSEPSVSWGFEVRMPPWATGDAVAETARRLRGCADAAPLHPL
                     RAQHMALQAARRGGNALRRASRLCARYGVPWHSPYADDRVLEAALSIRFADRAAPNTYK
                     NALATAMRGVVPDAILDRPTKGEFSADVYAGLRRHRAELLALCEDSHLARLGLIDPARL
                     REALLAPHPKSMTMLPLLNTLGTESWLRSVAELGKPAALGKPAAPRPQPVGGSR"
     gene            complement(12691..12816)
                     /locus_tag="HYQ63_RS23815"
                     /old_locus_tag="HYQ63_23815"
     CDS             complement(12691..12816)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="HYQ63_RS23815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23815"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_179935779.1"
                     /transl_table=11
                     /translation="MHQETAVYEPAVIEEIGDFAEVTLGGEGHGWDAVQECAMFC"
     misc_feature    12816..12830
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.21"
                     /tool="antismash"
     misc_feature    complement(12818..12829)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(12850..12864)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
     misc_feature    12852..12863
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.39"
                     /tool="antismash"
     gene            complement(12876..13001)
                     /locus_tag="HYQ63_RS23820"
                     /old_locus_tag="HYQ63_23820"
     CDS             complement(12876..13001)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="HYQ63_RS23820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23820"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_179935780.1"
                     /transl_table=11
                     /translation="MNDETITYEAPAIVDAGDFTEVTLGGGGGGADWEGLCWIFC"
     gene            complement(13082..14932)
                     /locus_tag="HYQ63_RS23825"
                     /old_locus_tag="HYQ63_23825"
     CDS             complement(13082..14932)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="HYQ63_RS23825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23825"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_179935781.1"
                     /transl_table=11
                     /translation="MSTIRINLLGAFEVVADDGRPLVPTGKQRTLLAALAVRCGRPVST
                     DVLIDTLWDGDPPPSARTTLRGTVRRLRRTLGDTDANEAYAVRSMPNGYQLDLDADAVD
                     LHLFRRLRAEAAGARGTGREPELLRRALGLWRGEALCDVESDALRGDLTAAVEEERVQT
                     TQRLMELETHAGQYERVITEARRLIAEHPLQERFREQLVRALDGAGRRPEALAEYERAR
                     VLLADELGVSPGAGLQRLYRRLLTDDEPERPTETTAGAAEDGGSAAVPRQVPLDVPGFT
                     GRASALATLDALLRAGADTVPPVVIEGAAGMGKSALAVHWAHRAAAHFPDGQLYLDLRG
                     YEARPAVEPYDALASLLRGIGVPDAGIPDDTADRAALFRSRTAGKRLLVLLDNARDAEQ
                     VTELLPAQSCLVVVTSRRRLRGLVVRWGARRVGLGPLDDAAVAELLGDAVADPDRAVTA
                     ELARLTGGMPLAVRLLAEYAQRCPGTPAAELAALLRDDRLRLDLLDSGDGQDPGLREAW
                     RSSVLHLEPGARALFELLGTHPMPDMTVDEAASYTGGEWQQAYRDLESLAALHLVDPLD
                     RFRYRLPALTCLFARELAAARRNGPRTTAIPLTYHRRLAA"
     gene            complement(15032..16993)
                     /locus_tag="HYQ63_RS23830"
                     /old_locus_tag="HYQ63_23830"
     CDS             complement(15032..16993)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014177633.1"
                     /locus_tag="HYQ63_RS23830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23830"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_179940433.1"
                     /transl_table=11
                     /translation="MQLRLVVADPATGRGRHRRPGRPRPYGRHQRAVQPLPEEYAYAPV
                     ITEGGEEAEPTAPQLPARLAFRRFWPLTKGDRRWIVLICVCVIAAALAETAAILLFSDL
                     TDNALRQGSLSAFWSPAAQWLAVAVLGAGVGYAGNSLAVWTAERFVMRLRARVFGHVQD
                     LPPHFFSRHRQGDLLERLTGDIDAIEQMVVSGVVGTVSAIFSTVFFSVAAFTLRWDLAL
                     ATFVLAPLFWLAARRFSGRIKSVAREERVADGAITSVVEESLANVVLTQAYNRKGAEED
                     RLRREAGAWMRASVSGARMSELYEQLVEVIETLCVLAVIGLGAWEISQGRMTIGQLLAF
                     AAFLGYLYPPIRNLGQLGLTLTAATAGAERLLEVLDAEPAVRDPAPGAAVQPWRVHGTV
                     EFDRVGFRYPGAERPTLAGVSLAARPGEFVLITGASGAGKSTVSKLLLRFYDPGEGYVR
                     LDGVPLHAVPLTFLRDHVTLLPQETLILHDTIRENIACGRPGASDHDVVRAARDAAADE
                     FIRALPQGYDTRIDPHTAQLSGGQLQRIAIARAMLRNAPVLVLDEPTTGLDALAARRVV
                     RPLRRLMAGRTTIMITHDLNLAPDADRILVLDHGRLVETGTHHELLALGGAYARLHGSQ
                     NGSLTDTGSHPTVQLGPS"
     gene            complement(17153..17278)
                     /locus_tag="HYQ63_RS44870"
     CDS             complement(17153..17278)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006380773.1"
                     /locus_tag="HYQ63_RS44870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_257232042.1"
                     /transl_table=11
                     /translation="MSFKKIAPVKPARKPAPAKKKHPKPAPKAPQQRQPRRPIGG"
     misc_feature    complement(17385..17403)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.3"
                     /tool="antismash"
     misc_feature    17540..17555
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.51"
                     /tool="antismash"
     misc_feature    complement(17543..17558)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.73"
                     /tool="antismash"
     gene            complement(17585..18997)
                     /locus_tag="HYQ63_RS23835"
                     /old_locus_tag="HYQ63_23835"
     CDS             complement(17585..18997)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573426.1"
                     /locus_tag="HYQ63_RS23835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23835"
                     /product="DUF2993 domain-containing protein"
                     /protein_id="WP_257232043.1"
                     /transl_table=11
                     /translation="MMRSPTRISSPRPHNSHRGSHPDDSRGAAQHDADDAAHRHADGAA
                     AQHDASHDADRDAPSAPYSNPYEELAELADPYDPDDPLGLGLKPDDDDTSDLGAAGGKD
                     GVNGEDGEPWSPPDHGRSRRGRRRGRGRFKAVPLTAKAVIGVLVLAALAVLADRCAVMY
                     VERKAEAALQKKLKLATAPNVTIHGFPFLTQVVDKKLKQVDVAVPDVAADRVSLAEVNV
                     QAQDIRLNADLPTSIKGAVVDCMKGDVLLAFEDLDRELGASQVRFRAFGPNSVRADGKL
                     PVAGQNVSLHAMAHIQRQGDRGISTEVTGMRLEIPGIATYRPGKNAGLRLHPKAAQQIS
                     KDTAKARALLEVPSVAERLGIAPEPAGRARQDDGQLDKITGSPTFVPALTKVNLVDVTN
                     EHPELVKKLGIDPTVAAALTKYKLPELSEKLSLSFQLPEKAKDIKIQNIGVEPDGIVAD
                     LTGTRMGFGKRP"
     gene            complement(19112..19372)
                     /locus_tag="HYQ63_RS23840"
                     /old_locus_tag="HYQ63_23840"
     CDS             complement(19112..19372)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716086.1"
                     /locus_tag="HYQ63_RS23840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23840"
                     /product="RNA-binding protein"
                     /protein_id="WP_179935782.1"
                     /transl_table=11
                     /translation="MSKRLHVGNLSYQTTKDDLEKLFAQFGAVMDATVITDRDTGRSRG
                     FGFVEMADMDAEKAMAQLDGQEMNGRCVTVTEARAVSRGGR"
     gene            complement(19490..20623)
                     /locus_tag="HYQ63_RS23845"
                     /old_locus_tag="HYQ63_23845"
     CDS             complement(19490..20623)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716085.1"
                     /locus_tag="HYQ63_RS23845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23845"
                     /product="NADH:flavin oxidoreductase"
                     /protein_id="WP_179935783.1"
                     /transl_table=11
                     /translation="MPASSAAADRAAQILSRPFTLGGLTVPNRIAMAPMTRQFSPGGVP
                     GADVAQYYARRAAGGVGLVITEGTYVGHDSAGDSDRVPRFHGEDALAGWKNVVAEVHQA
                     GGRIMPQLWHVGVTRAEGSGPVPDAPTVGPSGIGLDGNPAGRAMTQDDLDAVIAAFADA
                     AAAAERTGFDGIELHGAHGYLIDAFLWERTNQRTDGYGGDPVARTRFAAEIVAACRKAV
                     SADFPIVFRTSQWKSTNYDAKLATTPQELEAILTPLAEAGVDAFHSSTRRYWLPEFEGS
                     DLNLAGWTKKLTGKATISVGSVGLDKEFDPSAFRSGTRVGVAANIEKLLDRLERDEFDL
                     IAIGRALIADPEWVRKVLSGDTEALVPFAADQLQTLH"
     gene            20716..21150
                     /locus_tag="HYQ63_RS23850"
                     /old_locus_tag="HYQ63_23850"
     CDS             20716..21150
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716084.1"
                     /locus_tag="HYQ63_RS23850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23850"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_179935784.1"
                     /transl_table=11
                     /translation="MRIGELAAQAGVSVRALRYYEEQRLLHPERSASGQRHYPESAVDR
                     VHLIQQLYAAGLSSRTIVQLMPCVDTGEATPAMLELLLAERDRIERQMGELAEARDRLD
                     TVIASTKVSTCVHQPPRHQPPRHQPPRLTAAAAGPRRRPS"
     gene            complement(21110..21562)
                     /locus_tag="HYQ63_RS23855"
                     /old_locus_tag="HYQ63_23855"
     CDS             complement(21110..21562)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716083.1"
                     /locus_tag="HYQ63_RS23855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23855"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_179935785.1"
                     /transl_table=11
                     /translation="MDDVDRKILAELQKDGRLTVTELAERVRLSLSPCHRRLRALERSG
                     AISGYRAHLDAHALGLTFDALVFITMHDASRDTVAAFEQAVAAIPNVLQAQRLFGDPDY
                     LLRVVTRDLPAFQELYDDRLATLPGVQRLSSTLVMKDVVVDRPLPL"
     misc_feature    21538..21552
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.89"
                     /tool="antismash"
     misc_feature    21560..21575
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.9"
                     /tool="antismash"
     misc_feature    complement(21563..21578)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.75"
                     /tool="antismash"
     gene            21623..22414
                     /locus_tag="HYQ63_RS23860"
                     /old_locus_tag="HYQ63_23860"
     CDS             21623..22414
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716082.1"
                     /locus_tag="HYQ63_RS23860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_23860"
                     /product="thioesterase family protein"
                     /protein_id="WP_373689135.1"
                     /transl_table=11
                     /translation="MDSYFERTAEHRFKPTGHVGGAWASDEQHFSPLGGLIVHAIDRHL
                     AGRPETGMVLSRISFDILGRLALDECEVRVETLRPGRTIELVEATVLIADRAVVRARAW
                     LLTTLDTGAVAGGGPDRLTPPDALAPWAMSTVWPGGFIASLDVRPLAPPQPGRATVWVS
                     TGTDLVAGETATPLASYVALVDTANGIAVRQPPTAWMFPNVDLTLHLHRQPEGRWTGLD
                     TSVAFGPTGQGITSTVLHDLDGPVGHAQQILTVRPQPGEAP"
ORIGIN
        1 gtggcggtcg cggtgtcggc gttcgcgtgc tggctgatcg tgcgcgagca gctcaccgca
       61 cagctcgact cgtcgctgcg caccgtcaag gtcgacgagc gcaatgtggt gagcatcctg
      121 gacgcgtgcc agaaccccga cggcgacgac ggccacaccc cgcgcgccct cggctcgtac
      181 tccgtgcaga tcgtgctgcc cgacggcaac cgctgccccc agcccggggc gacggagctg
      241 ccggtgagcg ccgacgacgt ggcggtcgcc accgggcagc ggccgaccgc gctgcacgac
      301 gcgaccgccg aggacggccg cgacatgcgg gtcttcacgt accggccgtc cggcggtccc
      361 gacagcccgc tgccgcgcgg catcgccgtc tccatggccc gcccgctcag cgaggtccag
      421 gacccgctga acacgctcgc gctcgtcctc gccctcgtcg ccgggatcgg cgtcgtcggc
      481 gccggggcgg ccgggctgtg gatcgcccgg accgggctga agccggtgga ccggctgacc
      541 cacgccgtcg agcacgtggc ccgcaccgag gacctggccg tccgcatccc caccgagggc
      601 gacgacgaga tcgcccggct gtcccggtcg ttcaacgcca tgaccgccgc cctcgcctcc
      661 tcccgcgacc gtcagcagca gctgatcgcc gacgcggggc acgagctgcg caccccgctc
      721 acctcgctcc ggaccaacgt cgaactgctc gcccgcagcg acgagaccgg ccgcgccctg
      781 cctccggaag accgcaaggc gctcatgagc agcgtcaagg cgcagatgac cgaactggcg
      841 gcgctcatcg gcgacctcca ggagctgtcc cggccggacg cgctgcccgg cagcgggccg
      901 ctccaggtgg tcgcgctgca cgagatcgcg ggcgccgccc tggagcgggc ccggctgcgg
      961 ggcaccgggc tcaccatcga cgcctcgatc gagccctggt acgtacgcgg cgaggcggcc
     1021 gccctggaac gggcgctggt caacctgctc gacaacgccg tgaagttcag cccttcgggt
     1081 ggtgtcgtcg atgtcgcgct cagaaggggc gagttgacgg tgcgggaccg cggacccggc
     1141 attcccgacg atgaactccc gcacgtcttc gagcggttct ggcgttcgcc gtccgcccgc
     1201 agcatgcccg gctccgggct cgggctgtcc atcgtggccc gtaccgtcca acagtccggc
     1261 ggccaggtgg ggctgcggcc cgcaccgggc ggcggcaccg tcgcctggat ccgcctcccc
     1321 ggcgccccca ccgccccgcc cggactcgac ccctgaccct ccgccggcct tctcagcccc
     1381 cgtacacgcc ggactcagcg gacccacagc ctcgggcacc aggttggggc ccatgcacga
     1441 gacttcccgg atcctggtcg tggacgacga gccttcggta cgcgaagcca tcggcagagc
     1501 cctgcggttc gagggctacg aggtcgacac ggccggggac ggcgtggcgg cgctgcgccg
     1561 catcgaggag gagccgcccg acctggtgct gctcgaggtg atgctgcccg gtctggacgg
     1621 gctggccgtg gcccgccggc tccgggcctc cggccgcacc gtgccgatca tgatggtcac
     1681 cgggcgggac tccgtgggcg accgcatcgt cggcctcgac aacggcgccg acgactacct
     1741 gaccaagccc tacgcgtcgg aggaactgct cgcccgcgtc cgcgcgctgc tgcgccgcgg
     1801 ccggaccgtc cccgccgcgc cgcccgtctg cccgccctcc ccctggcagg ccccggcgcg
     1861 cccggagccg ggcgcgcggc tggccttcgc ggacgtgacc ctggacaccc tcacccgcca
     1921 ggtcacccgc tccggccgcc ccctcgacct caccaagacc gaattcgccc tgctgaagct
     1981 gttcttatcc cgcccgcgcc aggtcctcag ccgcgccgcg atcctccgcg acgtctgggg
     2041 cttcgacttc gagccgtcgt ccaacacgct ggacgtgtac gtgatgtacc tgcgccgcaa
     2101 gacggaggcc gggggcgagc cgcgcgtggt gcacacggtg cggggcgtcg gctatgtgct
     2161 gcggacggtg ccgggggatt agggtcggcc gttcgtacgt gacgtctgcg gagggcgctt
     2221 cggctgtgga aacgggggcc ggtgagcggg aggtggacct cgctgccgag cggtacggcg
     2281 tcggggtccg ggccacggtg atctccctgt gcggggtgtt cgggatcttc acggtcccga
     2341 ccgggcggtt accggtgacg gtgctgctgg tcgtcgtcac caccgccgcc tgcgcggtgc
     2401 ggtggtgggg gctgcggcgg ctcccggccg gggtacggat ggggctcgac gcgacggccg
     2461 tggcggtacc ggggctcgga cagcccctca tggggccgca gggcgtgaac atctgggtga
     2521 tggtcatcct ggggatcgcc gtcatcacct tccagtacga gtgggcgacc cggcccgcca
     2581 tcggcctcgg cctggccgcg ctgaccctcg ccacgtacgg cgtgggatac ggcctggccg
     2641 cccccgccct ggggccgtcg cccttctggg tggcggcccg gcagacggcc gagtgcgcgc
     2701 tcgcccgcgt ctcgtatctg atcgtccgcg ccaaggccag ggccgccgac cgggcgaccg
     2761 agcgcgaggc ggcgggacgc cgggaggcgt cggtcgccgc cgcccgccgc gccgccggac
     2821 gcgcctacct cgccacgctg cacgacacgg cgagcgccac gctgctgatg gtgtccctcg
     2881 ggggcgcccg cgactggtcc tggctcccgc gccgggccca ccgcgacctg gaggcgctgt
     2941 ccgccgtgcc cggccacgag gcgggccgcg tcgacctcgc ggaactgctg ggcgaggtgg
     3001 ccaagggcgc cgcggaaccg gacgcggtgc gggcggtccg ggtgtcggcc cggatcgacg
     3061 gccccctgat gatgcccgcg ggcgcggcgc tggccatcct gcacggcgtc ggcgcggccc
     3121 tggacaacgt ggtgcggcac gcggaggtgg acgaggccga cctgcgggcg ggccgggacg
     3181 cctcgggcac ggtcaccgtc gaactcaccg accgcggccg cggcttcctc cccgcggcgg
     3241 tctcggtgca gcgccggggg atatccggct cggtggtggg ccggatggag gcgatcggcg
     3301 gccgcggcga ggtcgactcc cgccccggcg agggaacccg cgtccgctgg gaatggccca
     3361 ccaccccgac ggaagccacc ccgcccgggg aagccccggc ggctgccgcc ccgcccgagc
     3421 gcgtcacccc cgagcccggc ccggacgggc gcaccgcgtt tcggcagatt catgggcggt
     3481 tggtgcgggg ggtgcggtgg gcgttgctgc tcgtcgcgtt gaccgtgcag gtcgggctgt
     3541 gcctgccgca gttcctcgct cacctgggca gctatcaccc gccctcggcg ccggtcgtcg
     3601 cgtacggggt gctgggcgcg gtcgcggtgt tcaccgccgg gctgctggcc tcggggcggg
     3661 acgtctcggg gtggccgcgg tggtgcgggg tcgggctggt gctgggggct tcggcgctgt
     3721 gtgccgtcac ggtcggggcc gaccagcggt tgcgcgaggg ggactgggcg ttcgggctgg
     3781 tcggctggca cgggctgtat ctgctgttcg ggctgtcggt gaccgcgatc ggggtgttcc
     3841 tgggggcgca gatcgtgctg accgcgatcc cggtggccct caccggcatg ccggacgtgg
     3901 cccggctggc gacgatgggg atgttcgcgc tgtcggtctg cggcttccag ttcacggtgg
     3961 gcgtcctggc ccggctgctg cgccggtcgg cggagacggc gggttcggcg gcggcccggg
     4021 aggaggagtt gcggacgcgc gaggcgatcg aggagcggat gcacctcgac cacgagaagc
     4081 gctacgcgac gctgctgcgc accaccgtgc cgctgctggc ggggctggcg cacggttcgc
     4141 tggatccgcg ggacgggcag gtcaggcacc ggtgcgcgct ggaggcggcc cggatgcggc
     4201 ggctgttcgc ggaggcggac gaggtgccgg accggctggt gcacgagctg cgcgcctgca
     4261 tcgacgtggc cgagcgggcg ggcgtgacgg tgggtctggc ggtgcgcggc gcgcgccggg
     4321 acgtgccgca ggacatccgc aggaagctgg cggacccggt ggcggcggtg ctggcggccg
     4381 gtccggccga ggcgcgggtg acggtggtgc gtaccggatc gcgggtacgg gtgagcgtcg
     4441 tgggcgacgg gacggcggag ccggacggcg tggccgtgaa ggagacgtcg ccggtggcgg
     4501 tgtcgcgtac ggcggatgga gagaaggtgt gggtggaggc ggtgtgggaa ccggctccgg
     4561 ccgccgggta gtgcagtctc ctggggacag ggggagccga gggaacatgg ggtgacgatg
     4621 ccgaccgaga ccgtcagcgt ggcgctgata gacgatcacc cggcgatccg cgcgggcgtc
     4681 gaggcgtggt acgcgtcctc ggaccagccg atcaaggtga tcgcggcggg ggagaccgcc
     4741 gccaccgcgt ggacaccgcc gggcgacggc gccgacgtcg tcgtgttcga ccttcagctg
     4801 agcgacgccg ggcccgcctt cggcgagttg cggcggctcg tggacgccgg gcgccaggtg
     4861 gtcgtgtaca cgatgcgcga cgaggagcag acggcgctga cctgcctgga tctgggcgcc
     4921 gcgacgtatc tgacgaagac cgagggcagc cgccacctgg tggccgcgac cctcgccgcc
     4981 gcccggcagc atccgtacac cccgcccgcg ctggcgggcg cgctggggac gaacgcgcgc
     5041 agcgacagac ccaggctgtc ccagcgcgag gaggatgtgc tgatcgagtg gttccagtcg
     5101 gagtccaagg aactggtggc gcagcggctg aacatcaagg tgcgcacggt caacacctat
     5161 ctggaccggg tgcggatcaa gtacgcgaac gcggggcgcc cggcgcggac gaaagcaggt
     5221 ctggtggcgc gggccatcca ggacgggctg gtggccgtcg aggatctgtg aggcgcggat
     5281 ccgtgaggcc cggggacccg cggtcgtcgc cgcgccagtg gcccaccagg ttcgcgtacg
     5341 tcgcgcagtc ccgcaccagc gacgcatggg tgccgccgtg caggcccgcc gtgtcgagca
     5401 cgaggacgcg gtcggcccgc agcgccgagc tgatgcggtg ggcgatgacg atgagggtgc
     5461 cctcccggct gcggaaggcg cgttcgaccc gctcctccgc gaccgggtcg agatggcagg
     5521 tggcctcgtc gaggatgacg acgcgggccg gggagagata gacccgggcc agggtgatga
     5581 gctgccgctg cccggcggag agggcggtcg ggcgcagggg tgtgccgtcg tagccgccgt
     5641 gctcgcgcac cagaccggtg aggccgagca cgctcaccgc gtggtccagc ctgcgctgtt
     5701 cgacgccggg gtggaggtag gtcaggttct cccggagcgt tcccgcgaag acgtacgcct
     5761 cctgggggac gagcgcgatg gccgagcgca gccagtcggt gcgcagggtg ggcagggagg
     5821 caccgccgag ccggaccgtg ccgcgctccg ggcgctccag ccccgcgagg acgcccacca
     5881 gcgtggactt gccgatgccg ctggccccga cgagggtgag gtgctgtccg tacgggacgg
     5941 tcacggtggc ccggtcgagg acgggcgcgg agtgcggccc gtagcggaac gtcacctcct
     6001 ccagggcgag gtcgtagcgg tccgtggtgt gcgggccgcc cgggtcgggc ggggcggggg
     6061 cggtgtggcg ggcgagccgc cccagcacgg tggccagttc gaggcccatg ttgccgacgg
     6121 agtggaccag ggcgcgcagc gccggttcga ggctggtgac caggtaggtg gccgcgccca
     6181 gcagctcacc cggggtcagc gcgtcgcccg ccaccagccg gggccccagc aggagcagca
     6241 gcaccagcgg ggtgcgggcg gcgaggccga tgaggccggt gcggacgccg ccgacggtgg
     6301 cgacggcctc ggcggcgcgc gcgttcgccc gcagccggtc ctccaggtcg gcggtagccc
     6361 ggcccacggc gccgcaggcc agtacgtcgc gcagggcccc gatgacgcgg ccggactcct
     6421 cggcgacggt ctcctcgctg tcgagggagg cgtcgtagcg gcgccgccag gtgcgggaga
     6481 gccgcagcag cgccaggccc gtcacacaca gcaccgggag gagcagcagc ccgacggcgg
     6541 gggcgagcgc ggtcagcccg gcgacggcgg cgaggaaggt gaacccggag gtgcaggcgg
     6601 tcatcagcag gttggagagc agctgccggg cgcgctcggt ctggtccgtg atccgggaca
     6661 cggcactggt gcgcggcggc tgaccgtcgg ccaccgcgcc gtgcagaccg ccgcgcacgg
     6721 tgacggtcac caggtggtcg cgcatcgcct ccacgacggt ggccatgcgg ggcaccgcct
     6781 gccgggtgcc gtacgcgccc gccaccatga ccagcccgta gacggcgagc gtgacgaggc
     6841 cagtgcgggc gtcgtcggcg aggaacccgc ggtcgagggc ggtcgcgacg agccgcccgg
     6901 acagcagcgc gggcgcggtg ccgagcagcg accatccgat gagcagggcc aggtcgcggc
     6961 ggtgcgcggc gaggaccggg cgcagcggat gacgcccggt gcgggagggc ttgcggtggg
     7021 ctccggtggg gggcatgccg ctcaccaccc cagccgcagt tgcatggtgg ggtgttcggc
     7081 gcccgggagc cgcagccgga gggtctcgtc gggggccggg ccggggtccg ccggggcggg
     7141 gcgcgggtcg ggcagctgga agacggcgcg gtactccggg tccttcagca gcgccttgtg
     7201 gggcgcgagc gcgcgcagcg tgccccggtc gagccaggcg accagatcgg ccccggcggc
     7261 ggtcgacatg cggtgggcga cgatcagccg ggtcgtcccg aacagcaccc ggtcgagcgc
     7321 ggcggtgatc tcggactcgg tcgcggtgtc gacgctggag gtggcgtcgt cgagcaccac
     7381 gagccgggcc tgccgggcgg cgacccgggc caggccgagg cgctggagtt cgccgccgga
     7441 gagccggagc cggtgcagcg gggtggccag cccgtcgggc agccgggtga cgaaggcgtc
     7501 ggcggagccc gcccgcaggg cggacgcgac ccggtgcggg ggcggcgggt ggtcggcgta
     7561 ggcgagggcg tcgccgaggg tgtcgccgag cagcgtgggg cgttcgaagg cgtagccgac
     7621 ggcgcggcgc agctcgtcgg ggcggatgtc gcgcagcggc accccgtcga ggaggacgtc
     7681 accggagtcg ggcgcgagca gtccgcccgc gatctcggtg agcgtggact tgcccgcgcc
     7741 ggacgcgccg atgacggcga cgctgtgccc ggcgggcacg tcgaggtcga ccccgttcag
     7801 cagcggggtc ccggaccgcg ccacgcggac gccgcgcagc gtgagccgcc cgggcccgtc
     7861 gggcagcggg cgggtgcccg cggacggcgc gggcacgtcg aggagttcgc cgatccgggc
     7921 ggccgagccg cggcaccggg cgagctgggc gagcatcgcg gtctgcttga gcagcccgag
     7981 cgcgtagccg agatacgcct gggaggcgag gagctcgccc ggggtgatcc ggccgtgcag
     8041 cacccccagc ccggcgacgg cgaggacgcc gatctggacc agcggcgtca ccagtccggc
     8101 ctgccaggtc gccttccgct gggtctgcca gaagtcgagc ccggcggcgc gcagccgggg
     8161 cagcggcgcc agcacccgcg cggcctcctg ctccgccgtc ccggccgccc ggatcgtccg
     8221 ggcgccgcgc agcgcgtcca cgaaccgctc cgccagctcc ccgtggatct cctggtacgt
     8281 gtgggtggcg gagccgaccc tgctcatcag ccagcggccg agccaccaca tcagcggcgc
     8341 cccgaggagg aagaacagcc cgagccggac gtcgatgagg aacagcccga ccagcccgcc
     8401 gagcgaggtg aggagcgacg cggcgagccc gacgaggtac tgggcggcgg gcgcggtccc
     8461 ggcgctcgac cccagcagcc ggctgaggac gtcgcccggg ccgaacgcgt cctgcccggc
     8521 ccggccgagg gccagcacct ggtgcagcac ccggcggcgc agcgccaggg tggcccgggc
     8581 cgccgagcgc ttctccagga tttcgcgggc ggcttcggtg gcggtggtga gggcgaggag
     8641 cgcgaagacc gcgatgacgg ggacgacggc ccggccctgc ggctccttcc cgatcgccgc
     8701 gtccagcgcg cccgccaggg cggccgggag cagcagccgg gtggccgggt ccagcaccgc
     8761 cacggcgagc aggcccggtc cgtgcgcgcc gctcgcgcgc agcgcgtcgc gcacgatgcg
     8821 gtcgctggat ggcatgacga actcccttgg cgccctggac gggtcggacg acggtcaggc
     8881 cgccggcggc ggcgtgccga cgggcggcgg gccgacgggc ccggccgggc cgatgggcgg
     8941 cgggccgacg cggcggcgga cctcggggaa cacctcggtg gtgaggcgtt cgaggttccg
     9001 cagcgagccg tgccgctcgc cggacacctc cacctggcac agcacccgcc gcgccccgca
     9061 cgtcgtgatg gcgtggacga gccgttcgac gcaggtgtcg acggtcccca ccgggtgctc
     9121 cgcgagcatc ttccgcgcca tccggtcgac cgtctcctcg tcctccccgg gcgtggcctg
     9181 ccgcggcccg tccccgtcgc cgatgatgat ctgcgagtcc tggttggccc ggagcgagcg
     9241 cttggcccgg tcccgcatga gggcgtgggc ctgctcctcg gtgtcggtga cctgggcgta
     9301 gacggcgaac gcgtggtcac cggccgccgg gtcccggtgg ccgtgttcat cggcgagggc
     9361 ggtgtgacgg gcgatcatgt cggccttcgc ggccgcgtcc ttgtcgaagt acagcagcat
     9421 cgggatgccg cgctcggcgg cgagggcgac cgagtcgggg gagcttgccg cgacgtacac
     9481 cggcgggccc tcgggggtgc gcggggtggg cgagaccgtc acgggccgga agcggtgcag
     9541 cgcggagtcg gccgacacct tcccggtcca cgcccgaagc gtgaggtcga gcgcctcgcc
     9601 gaggccgtcc ttccagtgcg ccgggccgcc gccgatcacc tcgtactcga cgaccggcag
     9661 cccgcgcccc acgccgagga cgaaccgccc ctgccccacg tggtccatga acgcggcctg
     9721 ttcggcgatg tgcaccgggg agtgcagcgg gagcagggcg acggccgtgc cgacccgcac
     9781 ccggctggtg gtgccgagca ggaacgaggc gaacgacatc gccgagggcg ccaccaccga
     9841 cggcaggaag tggtgctcgg tcacccacac gtcgtcaaga ccgagttcct ccgtcttacg
     9901 ggccacggcc accgagcgcg cgagcacatc ggcgtcgctc tgcccctcgt ggcggttggc
     9961 cgatatcagc gtgccgaagc ggaccggttc gcggaccggg tcagcggcgg tcatgggcgc
    10021 gcacctccat catcgtgcgg tagagcgtca cgtcctcgcg ctcgccgacg gcctgcccgt
    10081 cggcctccac ccaggcgtgc gcccggaacg gctgggtccg gaccccggtg caccagtcgg
    10141 gccacacccc ccacatccgg cacagcagcg ccgtggcgac ggagcgctga agacactgct
    10201 gggcggcgca ccgcctgctg acggcgacca cggcggcgcg ggcggcaccg gcggtggccg
    10261 cgtccgcggg acgggccccg cgccgcaccg actccagcac ccggcgcagc cgccgcgggc
    10321 gcagccgtac gagcagccgg gcggcgccga cggcgaaccg cgccgccgcg cggtggtgcc
    10381 acgggacccg ggtccggctc tccagcgtga ccggcatgct catgcggtca ccagcttcga
    10441 ccggcgcagc gaggcgagca gcttctcgac gtcctccgcg gcccgctcgg acccctcggg
    10501 ggtgcgggcg cggagggtgt ccaccacctc ggggacctcg ttgccctcca ggagcagccg
    10561 cagcaccagc gacgccgtgc ggttgagctg ccagtagcgc ccctgctcct cgtccagcag
    10621 gaccaggccg tcctcggtct cggacgcggt gacatgaggg gcgagcgcga tggtcatcgg
    10681 gaacctccaa cgggctgcgg gcgcggggcg gcgggcttgc cgagggcggc gggcttgccg
    10741 agctcggcca ccgagcgcag ccaggactcg gtgcccaggg tgttgagcag gggcagcatc
    10801 gtcatcgact tcgggtgcgg ggccaggagc gcttcgcgca gccgcgccgg gtcgatgagc
    10861 ccgagccggg ccaggtgcga gtcctcgcag agtgcgagca gctcggcccg gtggcggcgc
    10921 agccccgcgt acacgtcggc gctgaactcg cccttggtcg gccggtccag gatggcgtcg
    10981 ggcaccaccc cgcgcatcgc cgtggccagc gcgttcttgt acgtgttcgg ggcggcgcgg
    11041 tcggcgaagc ggatcgacag cgccgcctcc agcacccggt cgtcggcgta cgggctgtgc
    11101 cagggcaccc cgtaccgggc gcagaggcgg ctcgcccggc gcagcgcgtt cccgccgcgc
    11161 cgggcggcct ggagcgccat gtgctgggcg cgcagcggat gcagcggcgc ggcgtcggcg
    11221 cagccgcgca gccgccgggc cgtctcggcg accgcgtcgc ccgtcgccca gggcggcatc
    11281 cgcacctcga aaccccagct gacggacggt tcggagggcg gcggcggagg tgtgtccagg
    11341 cgccgcgcct gggccgcgat ccaggacccg tacgactggt tgtcggccag cgcgcgcagc
    11401 atcggcgcca gcttccagcg gcggtgcgcg cggccgacgc ggatgatgtg ggcggcgcgc
    11461 agcggatggg agcgcaccag cgtgtggtcg taggcgggcg ccgcgtagaa cagctcgtcc
    11521 ccgttgtggc cgctcaagtg cccccgggag ccgcccgcgg cgaggtgacg cgcctggtcg
    11581 gcgaggcggg tgcgggtcct gatccagggg aacgggccct ccaggtcggg gtccggttcg
    11641 agcagcccgg cgaagttgag gggcatctct tcccggggga tgatccggtg ctccgcgtcc
    11701 cccatggccc gcgccgcccg cgccgcccag acctcgtcgt cgttggcggc gtcggcggcc
    11761 tcgaagcggt aggtcagcag gtcgggggtg agcgatgcgg cgaggaagca cacactggtg
    11821 gagtccatgc cgcccgagag gtcggcgctg agacgtcccc cgtcgcccca ggacgccgac
    11881 atacgggccc tcaccgcgtc gcgcagcgcc tcgcggatcg cctccgcgcc ctcggccagc
    11941 ggtacctcgg gttccggcac ggtccaccag cgcgcggtgc cgctgccgcc gtcgggcgcg
    12001 agcgtcaggt aatggtcggc gggcaggcgc tccacgccct cccacagact gccctcctcc
    12061 agcggcccgg gcggcgccgc gtgcaacagc cggtccgcga gccgctgttc cgccaccccg
    12121 gcaccggtca gggcggcgag ggtgtcgggc cggtcggccg cgacggtgac gccctccacg
    12181 gcggccgtgt agatctggca cgaggccccg gcgctgccct gcgccctgac gacgccgtcg
    12241 acggccgcga ccaggtggaa gttgcccgcg gtcgtacggg ccagccggtc gaagtcggcc
    12301 gggcggcggg cgtccgcgag cgccgcggtg agcatggcgg gcgtcgcccc gctcgggccg
    12361 agcagggcga cgcgccgggc gccggcggtg gcctggacga tctcgtccgc gcgccaccgg
    12421 ccgaccaccc acgggcgccc ggacgcatgc ggaagaacgc tgagcggggg ccgtccggcg
    12481 gcggcctcct cctcggccgc cgcggccgtg atccggtccg cgatacggct ccccgcgggg
    12541 gaatccggaa gaatcacgaa ttccatgtcg tccttcgtcc tcggctttcg ctgatggggg
    12601 ctggtgggag gggaccgggc cggtccggcg cattgcgttc acgccgtacc ggcccggccg
    12661 cacattccgg aaaggttcag ccggaagggt tcagcagaac atcgcgcatt cctgcacggc
    12721 gtcccagccg tggccctcgc cgccgagcgt gacctcggcg aagtcaccga tctcctcgat
    12781 gacggcgggc tcgtagacgg ccgtctcctg gtgcatggtg ttcatttcct tctcgctttc
    12841 ctcgctatgt ggaaaaggga ttcagcgtgg gccggtcagc agaagatcca gcagaggccc
    12901 tcccagtcgg cgccaccgcc gccaccgccg agggtgacct cggtgaagtc cccggcgtcg
    12961 acaatggccg gtgcctcgta cgtgatcgtc tcgtcgttca tgagaacaag ccctctctca
    13021 tttgccgtcg tatgcagaat cgacccggga agcggaggcc accgctttcc cggctcatcc
    13081 cttacgctgc cagccggcgg tggtacgtca gtggtatggc cgtggtacgg ggcccgttcc
    13141 ggcgggccgc cgccaattcc ctggcgaaaa gacaggtcag cgcgggaagg cgatagcgga
    13201 atcggtccag cggatccacg agatggagcg cggcgaggct ttcgaggtcc cggtacgcct
    13261 gctgccattc cccgcccgtg tacgaggcgg cctcatcgac cgtcatatcc ggcatcggat
    13321 gggtaccgag cagctcgaac agcgcccgcg cccccggttc caggtgcagc acggagctgc
    13381 gccacgcctc gcgcagaccg gggtcctggc cgtcgccgga gtccagcaga tccagccgga
    13441 ggcggtcgtc gcgcagcagg gcggcgagtt cggcggccgg ggtgcccgga catcgctgcg
    13501 cgtactcggc cagcagccgg accgcgagcg gcatcccgcc ggtgagccgg gcgagttcgg
    13561 ccgtaacggc ccggtccggg tccgccacgg cgtcccccag cagctcggcc acggccgcgt
    13621 cgtccagcgg gccgaggccg acccgccgcg caccccagcg caccaccaga ccgcgcagcc
    13681 gccgcctgct ggtgaccacc accagacagc tctgcgcggg cagcagttcg gtgacctgct
    13741 cggcgtcgcg cgcgttgtcc aacagcacca gcagccgctt tccggcggta cggctgcgga
    13801 agagcgccgc ccggtcggcg gtgtcgtccg ggataccggc gtcgggcaca ccgatgccgc
    13861 gcagcagcga ggccagcgcg tcgtacggct ccacggcggg ccgcgcctcg taaccgcgca
    13921 gatccaggta gagctggccg tccgggaagt gggccgcggc gcggtgcgcc cagtgcacgg
    13981 ccagcgcgct cttccccatc cccgcggccc cctcgatgac cacgggcggg acggtgtcgg
    14041 ccccggcgcg gaggagggcg tcgagcgtgg cgagggcgga cgcgcgcccc gtgaagccgg
    14101 ggacgtccag cgggacctga cgaggcaccg ccgcactgcc gccgtcctcc gcggcaccgg
    14161 ccgtcgtctc cgtggggcgc tccggctcgt cgtcggtcag cagccgccgg tacagccgct
    14221 ggagcccggc ccccgggctg acgcccagtt cgtcggcgag cagcacccgg gcccgctcgt
    14281 actccgcgag cgcctccggc ctgcggcccg ccccgtccag cgcccgcacc agctgctccc
    14341 ggaagcgctc ctgcaagggg tgctccgcga tcagccgccg tgcctcggtg atgacccgct
    14401 cgtactgccc ggcgtgcgtc tccagctcca tcagccgctg tgtcgtctgg acgcgttcct
    14461 cctcgacggc ggccgtcagg tcgccgcgca gggcgtccga ctcgacgtcg cacagcgcct
    14521 cgccgcgcca cagcccgagg gcccgccgga gcagttccgg ctcccgcccg gtgccccggg
    14581 cgcccgcggc ctcggcccgc agccgccgga agaggtgcag gtcgacggca tcggcgtcga
    14641 ggtcgagctg gtagccgttc ggcatcgacc gcaccgcgta cgcctcattg gcgtccgtgt
    14701 ccccgagggt gcggcgcagc cgccgcacgg tgccgcgcag ggtggtgcgc gcggacggcg
    14761 gcgggtcccc gtcccacagc gtgtcgatga ggacgtcggt ggagaccgga cgcccgcagc
    14821 gcaccgcgag agcggccagc aacgtgcgct gcttgcccgt cggcacgagc ggccgtccgt
    14881 cgtccgccac cacctcgaac gcgccgagca ggttgatccg tatggtgctc atgaacgtgc
    14941 ttccccctgt gttccgagct gggttgacca gccctgttga ccgtagggaa gcgcggtggg
    15001 aagcacagac ggccgaacga ccgacaatct ctcaggacgg gccgagctgg accgtggggt
    15061 gggatccggt gtccgtcagg gagccgttct gggagccgtg gaggcgggcg taggcgccgc
    15121 ccagggcgag cagttcgtgg tgggtgccgg tctccaccag gcggccgtgg tcgaggacca
    15181 ggatgcggtc ggcgtccggg gccaggttga ggtcgtgggt gatcatgatc gtcgtacggc
    15241 ccgccatcag ccgccgcagc ggccggacca cgcgccgtgc ggccagggcg tcgagtccgg
    15301 tggtgggttc gtcgaggacc aggacggggg cgttgcgcag catcgcccgg gcgatggcga
    15361 tccgctggag ctggccgccg gagagctggg ccgtgtgcgg gtcgatgcgg gtgtcgtacc
    15421 cctggggcag ggcgcggatg aactcgtcgg cggccgcgtc ccgcgccgcc cggacgacgt
    15481 cgtggtcgct cgcgcccggc cgcccgcacg cgatgttctc gcggatcgtg tcgtgcagga
    15541 tcagcgtctc ctgcggcagc agggtcacgt ggtcgcgcag gaaggtgagc ggtacggcgt
    15601 gcagcggcac cccgtccagc cgtacgtagc cctcgcccgg gtcgtagaag cgcagcagca
    15661 gcttggagac ggtcgacttg cccgccccgc tcgcccccgt gatcaggacg aactcacccg
    15721 ggcgggcggc cagcgacacc ccggccaggg tcggccgttc ggcgcccggg tagcggaagc
    15781 cgacccggtc gaactcgacc gtgccgtgca cccgccacgg ctggacggcc gctcccggcg
    15841 cgggatcgcg cacggcgggt tcggcgtcga ggacctccag cagccgttcg gcgcccgcgg
    15901 tcgcggcggt gagggtcagg cccagctgcc cgaggttgcg gatcggcggg tagaggtagc
    15961 cgaggaaggc ggcgaaggcg agcagctggc cgatcgtcat ccggccctgg gagatctccc
    16021 aggcgccgag cccgatgacg gcgagtacgc acagcgtctc gatgacctcc accagctgct
    16081 cgtacagctc gctcatgcgc gccccggaca ccgaggcccg catccacgcc ccggcctccc
    16141 gccgcagccg gtcctcctcg gcgcccttgc ggttgtacgc ctgggtgagc acgacgttcg
    16201 cgagggactc ctcgaccacc gaggtgatcg cgccgtcggc gacccgctcc tcccgggcga
    16261 ccgacttgat gcggccggag aagcgccgcg cggccagcca gaacagcggc gccaggacga
    16321 aggtggccag cgccaggtcc cagcgcagcg tgaacgcggc gaccgagaag aagacggtgc
    16381 tgaagatcgc cgacacggtg cccaccacgc cggacaccac catctgctcg atggcgtcga
    16441 tgtccccggt gagacgctcc agcagatcgc cctggcggtg gcgggagaag aagtgcggcg
    16501 gcaggtcctg gacgtgcccg aagacccggg cccgcagccg catcacgaag cgctcggcgg
    16561 tccagacggc gagcgagttg cctgcgtagc cgacgcccgc gcccaggacg gcgaccgcga
    16621 gccactgcgc cgcggggctc cagaacgcgc tgagcgaccc ctgccgcagg gcgttgtcgg
    16681 tgaggtcgga gaagagcagg atcgcggcgg tctcggcgag cgccgcggcg atgacgcaga
    16741 cgcagatcag cacgatccag cggcgatcgc ccttggtcag cggccagaac cggcggaacg
    16801 ccagccgcgc cgggagctgc ggagcggtcg gctccgcctc ctcgccgccc tccgtgatga
    16861 cgggggcgta cgcgtactcc tcgggcagcg gctgcaccgc ccgctggtgg cggccgtacg
    16921 ggcggggccg cccggggcgc cggtgccgac cgcggccggt cgcgggatcg gccacgacca
    16981 ggcgcagctg catggtggcc tggtcgtcgt acgagggcga ggacgacggc gaggacgacg
    17041 gcgaggatga gggcggtggc ggtggtgagg tcacgtgggg tctcccgggt ccggaaacgg
    17101 ccgaggcggg cccgtggcgc gattgccgcg ggcccgcctt tcagggggcg ggtcagccgc
    17161 cgatggggcg acgcggctgg cgctgctgcg gggccttcgg ggccggcttg gggtgcttct
    17221 tcttcgccgg ggcgggcttg cgggcgggct tgaccggggc gatcttcttg aagctcatga
    17281 tgttttcctc tcgctatgac ggcgattctt tttcttttgt ctgggccgtt cggcttcgac
    17341 acggaaaaca ttaggagggc tatccgtgag tgagttcgga ctcggctgtg tgtttgccca
    17401 gagccgtctg acggatttct caggcgatcg cgggaaccgc cgcggacccg tctgcgtcct
    17461 gcgtgggcgc gcctgttcag gcatgacgaa ggggccggtg gcgccatgcc accggcccct
    17521 tcgacgggtc accgcgctat ttgagaatcc tcatctttgc agcgtgcggc gctttatggc
    17581 cgctttatgg ccgctttccg aagcccattc gggtgccggt gaggtcggcc acgatcccgt
    17641 ccggctccac accgatgttc tggatcttga tgtctttggc cttctccggc agctggaagg
    17701 agagcgacag cttctccgac agctccggca gcttgtactt ggtcagcgcg gcggccaccg
    17761 tcgggtcgat gccgagcttc ttgaccagct cggggtgctc gttcgtcacg tcgacgaggt
    17821 tgaccttcgt cagcgcgggc acgaacgtcg gcgacccggt gatcttgtcc agctgcccgt
    17881 cgtcctgacg cgcccgcccg gccggttcgg gagcgatccc cagtcgctcc gccaccgacg
    17941 gcacctccag cagcgcccgc gccttcgcgg tgtccttgct gatctgctgg gccgccttgg
    18001 ggtgcagccg cagcccggcg ttcttgcccg gccggtaggt ggcgatcccg ggtatctcca
    18061 gccgcatgcc cgtcacctcg gtggagatcc cccggtctcc ctggcgctgt atgtgggcca
    18121 tcgcgtgcag cgacacgttc tgcccggcca ccggcagctt gccgtccgcg cgcaccgagt
    18181 tggggccgaa cgcccggaac cgcacctggg aggcgcccag ttcccggtcg aggtcctcga
    18241 aggccagcag cacgtcgccc ttcatgcagt ccaccacggc gcccttgatg gaggtgggca
    18301 gatcggcgtt cagccggatg tcctgggcct ggacgttcac ctcggcgagc gagacgcggt
    18361 cggccgccac gtcgggcacc gccacgtcga cctgcttcag cttcttgtcc accacctggg
    18421 tgaggaacgg gaagccgtgg atggtcacgt tgggggcggt ggccagcttg agcttcttct
    18481 gtagcgcggc ctccgccttg cgctccacgt acatcacggc gcaccggtcg gccagcaccg
    18541 ccagcgccgc gagcaccagc accccgatga ccgccttcgc ggtgagcggc accgctttga
    18601 agcgcccgcg gccgcgccgc cggccgcgcc gggagcggcc gtggtcgggc ggcgaccacg
    18661 gctcgccgtc ctccccgttc acgccgtcct tgccgccggc ggccccgagg tcggaggtgt
    18721 cgtcgtcgtc cggcttcagc ccgaggccga gcgggtcgtc cgggtcgtac ggatcggcca
    18781 gctcggcgag ttcctcgtac gggttgctgt acggggcgct cggcgcgtcg cggtccgcgt
    18841 cgtgcgacgc gtcgtgctgc gcggcggcgc cgtccgcgtg gcggtgcgcg gcgtcgtccg
    18901 cgtcgtgctg cgcggcgccg cgcgagtcgt cggggtgcga gccgcggtgc gaattgtggg
    18961 gacgaggtga agatatgcgt gtgggggatc gcatcatcca ataccaccac gccacactgc
    19021 tccacccgca agtcctagcg gcgatacgtg gcgaacggca cgctcacgca acggaatccg
    19081 ccgtgccgtc cgcccccgtc cccgcccccg ttcaccgccc gccgcgcgaa accgcccgtg
    19141 cctcggtgac ggtgacgcac cgcccgttca tctcctgtcc atccagctgg gccatggcct
    19201 tctcggcgtc catgtccgcc atctccacga acccgaaccc ccgtgagcgc ccggtgtccc
    19261 ggtcggtgat gacggtcgcg tccatcaccg ccccgaactg cgcgaacagc ttctccaggt
    19321 cgtccttcgt ggtctggtag ctcagattgc ccacgtgcag ccgcttcgac atgacccgct
    19381 ctccctgcct gctccgggac gccgtcaagg tggcgccaat cgggtcaatc gtcgcagcga
    19441 gggaggaagc gggccattgc gattgggctg aacggtgacc cggccgggct cagtgcaggg
    19501 tctggagctg gtcggcggcg aacgggacga gcgcctccgt gtccccgctg agcaccttcc
    19561 ggacccactc cgggtcggcg atcagggcgc ggccgatcgc gatgaggtcg aactcgtccc
    19621 gctccagacg gtccagcagc ttctcgatgt tggccgccac cccgacccgg gtcccgctcc
    19681 ggaacgccga gggatcgaac tccttgtcca ggccgacaga gccgacgctg atggtggcct
    19741 tgccggtgag cttcttcgtc cagcccgcca ggttcagatc cgagccctcg aactccggca
    19801 gccagtaccg gcgggtggag gagtggaagg cgtccacccc ggcctccgcg agcggggtga
    19861 ggatcgcctc cagctcttgc ggggtcgtgg cgagcttcgc gtcgtagttg gtcgacttcc
    19921 actgcgaggt gcggaagacg atcgggaagt ctgcggagac ggccttgcgg cacgcggcca
    19981 cgatctcggc ggcgaagcgg gtacgggcga ccgggtcgcc gccgtagcca tcggtgcgct
    20041 ggttggtgcg ctcccacagg aacgcgtcga tcagatagcc atgggcgccg tgcagttcga
    20101 tcccgtcgaa gccggtccgc tcagcggccg ccgcggcgtc ggcgaaggcg gcgatcaccg
    20161 cgtccaggtc gtcctgggtc atggcccggc ccgcggggtt gccgtcaagg ccgatgcccg
    20221 acgggccgac cgtcggggcg tcggggaccg gtcccgagcc ctcggcgcgc gtcaccccga
    20281 cgtgccagag ctgcggcatg atccggccgc cggcctggtg cacctccgcc accacgttct
    20341 tccagcccgc cagggcgtcc tccccgtgga agcgcggcac ccggtcgctg tcccccgccg
    20401 agtcgtggcc gacgtacgtc ccctcggtga tgaccagccc gaccccaccg gccgcccggc
    20461 gcgcgtagta ctgcgccaca tcggcgccgg ggacgccgcc cggcgagaac tggcgcgtca
    20521 tcggcgccat ggcgatccgg ttcggcacgg tgagcccgcc cagggtgaac gggcgggaca
    20581 ggatctgagc cgcgcggtcg gcggcagcgc tgctggcagg cacgtgaagg ctcctcgaag
    20641 cagatgatgt ttcgcggagc taagctaaaa cctgacgttg acgtcagggg caaatgtcgc
    20701 agggaggaga cctgagtgcg catcggtgaa ctcgccgcgc aggcaggagt gagcgtacgg
    20761 gcgctgcgct actacgagga gcagcgcctg ctccacccgg agcgcagcgc cagcggccag
    20821 cggcactacc ccgagagcgc ggtcgaccgc gtccatctga tccagcagct gtacgcggcg
    20881 gggctgtcga gccggaccat cgtgcagctg atgccgtgcg tcgacaccgg tgaggcgacc
    20941 ccggcgatgc tggaactgct gctcgccgag cgcgaccgca tcgaacgtca gatgggcgag
    21001 ctggccgagg cccgcgaccg gctcgacacc gtgatcgcct ccacgaaggt gagcacctgc
    21061 gtgcaccagc cgccccggca ccagccgccg cggcaccaac cgccccggct cacagcggca
    21121 gcggccggtc cacgacgacg tccttcatga cgagggtgga gctgaggcgc tgcacgccgg
    21181 ggagcgtggc gaggcggtcg tcgtacagct cctgaaaggc gggcaggtcg cgggtgacca
    21241 cgcgcaacag atagtcgggg tcgccgaaga gccgctgcgc ctggaggacg ttggggatgg
    21301 cggcgacggc ctgctcgaag gcggcgacgg tgtcccggga cgcgtcgtgc atcgtgatga
    21361 agacgagggc gtcgaaggtg aggccgaggg cgtgcgcgtc gaggtgcgcg cgatagccgc
    21421 tgatcgcgcc ggagcgctcc agggcgcgca gcctccggtg gcacggcgag aggctgaggc
    21481 gcacgcgctc ggcgagctcc gtgacggtga ggcgcccgtc cttctggagc tcggcaagga
    21541 ttttccggtc cacgtcatcc atgaggaaga ttctccctca cccttacggt ggtctcgtca
    21601 acgcctgcca aggagaaacc cgttggacag ctacttcgag cgcaccgccg aacaccgctt
    21661 caagcccacc ggccacgtag gcggcgcatg ggcctccgac gaacagcact tcagcccgct
    21721 cggcggcctg atcgtgcacg ccatcgaccg ccacctggcc gggcgtccgg agaccggcat
    21781 ggtcctgagc cgcatcagct tcgacatcct cgggcgcctc gccctcgacg agtgcgaggt
    21841 ccgggtggag accctccggc ccggccgcac catcgaactc gtcgaagcca ccgtgctcat
    21901 agcggaccgc gcggtggtcc gggcccgcgc ctggctcctg accacgctgg acaccggcgc
    21961 cgtcgcgggc ggcggccccg accggctcac cccgcccgac gcgctcgcgc cctgggccat
    22021 gtccaccgtc tggcccggcg ggttcatcgc ctccctggac gtccggccgc tcgccccgcc
    22081 gcagcccggc cgcgccaccg tctgggtctc caccgggacg gacctcgtcg ccggggagac
    22141 cgcgaccccg ctggcgtcct acgtcgccct ggtcgacacc gccaacggca tcgccgtccg
    22201 ccagccgccc accgcctgga tgttccccaa cgtggacctg accctccacc tccaccggca
    22261 gcccgagggc cgctggaccg gactcgacac cagcgtcgcc ttcggcccga ccggccaggg
    22321 catcaccagc accgtcctgc acgacctcga cggacccgtg ggtcacgcac agcagatcct
    22381 cacggtccgc ccccagcccg gtgaagcgcc ttgaccatca tctgctcccc ggtcacgccg
    22441 tcggacgaca gatacacgaa cccgttgcgc cggtagaggg cgatggccgc gtcgttgccc
    22501 gggagcacgc cgagcgtcag cgtcgtaccg cccgaacggc gcgcccatcc ctcgaccgcc
    22561 ccgatc
//
