LOCUS       NZ_CP058693            22520 bp    DNA     linear   CON 08-SEP-2024
DEFINITION  Streptomyces sp. Rer75 chromosome.
ACCESSION   NZ_CP058693
VERSION     NZ_CP058693.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Rer75
  ORGANISM  Streptomyces sp. Rer75
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Genome analysis of Streptomyces sp. Rer75
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-JUL-2020) College of Pharmacy, Henan University of
            Chinese Medicine, Jinshui East Road No. 156, Zhengzhou, Henan
            450046, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. Canu V1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 76.63x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013414305.1-RS_2024_09_08
            Annotation Date                   :: 09/08/2024 05:25:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,857
            CDSs (total)                      :: 8,765
            Genes (coding)                    :: 8,460
            CDSs (with protein)               :: 8,460
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 305
            CDSs (without protein)            :: 305
            Pseudo Genes (ambiguous residues) :: 0 of 305
            Pseudo Genes (frameshifted)       :: 145 of 305
            Pseudo Genes (incomplete)         :: 204 of 305
            Pseudo Genes (internal stop)      :: 20 of 305
            Pseudo Genes (multiple problems)  :: 62 of 305
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:27:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1946665
            Orig. end                         :: 1969185
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058693.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22520
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /region_number="11"
                     /rules="(micKC and not PKS_KS)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..22520
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="interleaved"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22520
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12520](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12520
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(1059..>1289)
                     /locus_tag="HYQ63_RS07750"
                     /old_locus_tag="HYQ63_07750"
                     /pseudo=""
     CDS             complement(1059..>1289)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012798.5"
                     /locus_tag="HYQ63_RS07750"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07750"
                     /product="tyrosine-type recombinase/integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="PDGSPLRPQGVLAELRRRAAELGLPRIGVHDLRHTAATIMISSRV
                     PLAVISKTLRHSTLATTVNLYGHLLLCLPNT"
     gene            1748..1948
                     /locus_tag="HYQ63_RS07755"
                     /old_locus_tag="HYQ63_07755"
     CDS             1748..1948
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYQ63_RS07755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYQ63_07755"
                     /product="hypothetical protein"
                     /protein_id="WP_179933164.1"
                     /transl_table=11
                     /translation="MNSNKVVRTLRRSSATFLAGAMLALAAHGVTYAADGASAPWPGRA
                     VIAPVDLPFPAIEPSRTNDWG"
     misc_feature    1775..1777
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2007..2972
                     /locus_tag="HYQ63_RS07760"
                     /old_locus_tag="HYQ63_07760"
     CDS             2007..2972
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980804.1"
                     /locus_tag="HYQ63_RS07760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07760"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_179933165.1"
                     /transl_table=11
                     /translation="MTELSVLIPFVPRRLEQVLPFAGLVNWTSAARLWQGQSMVLEPHQ
                     TFVGVAGAGFRVPAGLGVTLMPLRNPFEAATQARSVALATGHPVTAGFGTGAVQFQRNI
                     LGSAYSSPLNTARAYVTAVRSLLDGELVQSDGTEFTLTGQLPPAVAPRVDVGLGVLRPG
                     MARLAGEVADAVITWLTPPSYLKDVLVPAVAEGMKKAGRTRRPRIIAMVPVGVRRDETD
                     PERLALASNLAHLQAPHYQDMLRRAGADIGDGNDVHQAARAVVDTGGFVTGDLDDVLKG
                     LDAYQQAGADEIVLNTTGVNKMFGSPEALADLRTILKAHQ"
     gene            3016..4035
                     /gene="mpaB"
                     /locus_tag="HYQ63_RS07765"
                     /old_locus_tag="HYQ63_07765"
     CDS             3016..4035
                     /codon_start=1
                     /gene="mpaB"
                     /inference="COORDINATES: protein motif:HMM:NF041823.1"
                     /locus_tag="HYQ63_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07765"
                     /product="daptide biosynthesis RiPP recognition protein"
                     /protein_id="WP_179933166.1"
                     /transl_table=11
                     /translation="MDTIARRRAKQHIMSWGSGHVRPDRVPAGQAATVVLANRAHLDDA
                     VSSGVIGDSTVAFAPRTSDGPVVGYDGALDEPGTELALGHDFYLQTQDYASSAYMTVLG
                     PTIVRLFTNEDFAACLRDADRALEEGAFPEFLITPSVLLADTSGLGGGPAGDGPLTRLY
                     ADRAGNWSTSPRGAVLGTIGDSLDTLIARYEEINAASPAPCAVALAAVISDPDRSAALR
                     ERPYLGRYLAAVRALRSVIARGAHEPKVSGFGVRLVPGLVLEGPDVTDAEAPLVMFTEE
                     EAYVSAAGRLFSVSRDVAGAVECLLAGAADPDSAERLSQVRDYFTQQGVPLPEPVVVA"
     gene            4035..4841
                     /gene="mpaM"
                     /locus_tag="HYQ63_RS07770"
                     /old_locus_tag="HYQ63_07770"
     CDS             4035..4841
                     /codon_start=1
                     /gene="mpaM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF041820.1"
                     /locus_tag="HYQ63_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07770"
                     /product="daptide-type RiPP biosynthesis methyltransferase"
                     /protein_id="WP_179933167.1"
                     /transl_table=11
                     /translation="MTPVATPFLPGQAGERVAQLGDRARLCGLYDEDGSGVYDDLAAAD
                     GFEIRDIIIAVRTLDGPVLDLAAGSGRFTLPLLALGRDVTALDMSPHMLSLLTQRLART
                     PERVRERCTVVQADMSGFTLRQRFAHVLLGTTSLSLLDSSGRAGLYRCVADSLSEGGQF
                     LVSVLERGGDGDPDEVVQRAHGASGTPYDLYEYWPTGASHRTVTIVPADPPPTGHVVVA
                     HDEVPSMSISTIERELHQAGFTALDQRELTPVGQRHRVVLIKAVRA"
     gene            4838..6100
                     /gene="mpaD"
                     /locus_tag="HYQ63_RS07775"
                     /old_locus_tag="HYQ63_07775"
     CDS             4838..6100
                     /NRPS_PKS="Domain: Aminotran_3 (22-348). E-value: 3.8e-64.
                     Score: 208.8. Matches aSDomain:
                     nrpspksdomains_HYQ63_RS07775_Aminotran_3.1"
                     /codon_start=1
                     /gene="mpaD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980801.1"
                     /locus_tag="HYQ63_RS07775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07775"
                     /product="daptide-type RiPP biosynthesis aminotransferase"
                     /protein_id="WP_179933168.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4.4e-65, bitscore:
                     218.9, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGNILWPYLIAPSAHGSDRQCAVQAAGHRITFADGSTVLDGDSG
                     LWNANLGYGNPVIADAIGEATREASYLGAFRFENSYARGAATDLLAVADTENYARVLFS
                     SGGGVANDAAMKLVRQYHALDGHPERNLIVALRGSFHGLTFGGFALTGEELGQRVYGVD
                     QRLIRHINPNDIGELRDLIQRIGRQVAALVVEPVLGTGTIPLGADYIEELLRLRDRSGF
                     LLVADEVATGFGRTGSFFASHTWPGRPDVLITSKGLTNGTMPASAVIFSHQVAEIFTRH
                     DAILTHAETQGGTAVSCAAIRATINEMQRLDAVVSGRRVADRLAARIDELVDQHPLVNH
                     STGQGCFRTLHLRGPGGHRLAPPGVAWLVGRIRDEGAIVHPGPSGIQLVPALTWTDAET
                     DELMACVQTGLNALTAVAARH"
     aSDomain        4904..5881
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HYQ63_RS07775_Aminotran_3.1"
                     /evalue="3.80E-64"
                     /label="HYQ63_RS07775_Aminotran_3.1"
                     /locus_tag="HYQ63_RS07775"
                     /protein_end="348"
                     /protein_start="22"
                     /score="208.8"
                     /tool="antismash"
                     /translation="AVQAAGHRITFADGSTVLDGDSGLWNANLGYGNPVIADAIGEATR
                     EASYLGAFRFENSYARGAATDLLAVADTENYARVLFSSGGGVANDAAMKLVRQYHALDG
                     HPERNLIVALRGSFHGLTFGGFALTGEELGQRVYGVDQRLIRHINPNDIGELRDLIQRI
                     GRQVAALVVEPVLGTGTIPLGADYIEELLRLRDRSGFLLVADEVATGFGRTGSFFASHT
                     WPGRPDVLITSKGLTNGTMPASAVIFSHQVAEIFTRHDAILTHAETQGGTAVSCAAIRA
                     TINEMQRLDAVVSGRRVADRLAARIDELVDQHPLVNHSTGQGCFR"
     gene            6188..6334
                     /locus_tag="HYQ63_RS07780"
                     /old_locus_tag="HYQ63_07780"
     CDS             6188..6334
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482722.1"
                     /locus_tag="HYQ63_RS07780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07780"
                     /product="daptide-type RiPP"
                     /protein_id="WP_179933169.1"
                     /transl_table=11
                     /translation="MTDRNLAEEPQIDACELEMQELEALEAPGFWTGVSIGTVVSVSVV
                     AAT"
     misc_feature    complement(6221..6235)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            6456..7772
                     /gene="mpaC"
                     /locus_tag="HYQ63_RS07785"
                     /old_locus_tag="HYQ63_07785"
     CDS             6456..7772
                     /codon_start=1
                     /gene="mpaC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF041822.1"
                     /locus_tag="HYQ63_RS07785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07785"
                     /product="daptide-type RiPP biosynthesis dehydogenase"
                     /protein_id="WP_179933170.1"
                     /sec_met_domain="Fe-ADH (E-value: 3.8e-28, bitscore: 97.3,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTAARAARQAFTLPAAPLRSIGSLAEWLRGDEADAVTMICDPA
                     LTGQPVTVGVRDQIRSAGITSRVVTLPINRDAEAIRSLAARLAPRELVVAIGGGSTLDF
                     AKLTALSAIQPDIYRYLTAPQRSGFLLLPPHLGNSVRVLAVPTTLGTGSELGTVACFER
                     AGHKLLVTGSCLRPVQAMWIAEATDTLPADLVADGVLEALFRTVSPYTGDPAPLPEQDA
                     AVEDLAVRLIQAGDEVARLRAAGNPIPADLRLRIAEMSAQSQIGHLNIGRSPYAVKCWC
                     IANELSTLLGLAKMRTVSAVWPVLWRHCLAGNDRLGSPDRILSLWTVIRGTFPHFGQDP
                     VTGLERLMDAWRIERTVHAGTRQVEETTERIMRAWGAGLPILDGVRAQEIRRLLTDATY
                     STADGVVSPPGTVGPPDHRTPTEPDRVHAEEHTIRAHQA"
     protocluster    7520..18770
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12519:13770](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12520..13770
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            7805..7954
                     /locus_tag="HYQ63_RS07790"
                     /old_locus_tag="HYQ63_07790"
     CDS             7805..7954
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002403.1"
                     /locus_tag="HYQ63_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07790"
                     /product="daptide-type RiPP"
                     /protein_id="WP_179933171.1"
                     /transl_table=11
                     /translation="MDHIEVELQNLTISELEMQELEALEAPGWATSAGVSVGISVVSVA
                     WSLT"
     gene            8051..8194
                     /locus_tag="HYQ63_RS07795"
                     /old_locus_tag="HYQ63_07795"
     CDS             8051..8194
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980799.1"
                     /locus_tag="HYQ63_RS07795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07795"
                     /product="daptide-type RiPP"
                     /protein_id="WP_179933172.1"
                     /transl_table=11
                     /translation="MENITNEAPALELEMQELEALEAPGFWTGVSIGATISSAVGTSIA
                     LT"
     gene            8348..9982
                     /gene="mpaP"
                     /locus_tag="HYQ63_RS07800"
                     /old_locus_tag="HYQ63_07800"
     CDS             8348..9982
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mpaP"
                     /inference="COORDINATES: protein motif:HMM:NF041824.1"
                     /locus_tag="HYQ63_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07800"
                     /product="daptide biosynthesis intramembrane
                     metalloprotease"
                     /protein_id="WP_306664877.1"
                     /transl_table=11
                     /translation="MSTTTAPVLPDAQRPRLAPGIEVHPPMGDGGSWVIQHGPRYIRVS
                     ASVASLAQRLDGETTIDALAGSMGVPWTAELVTDAVGRFDALRLLDRGEQTPKKKQRSS
                     RIKLVPPFTVQLTLLSPGRTMQALQPALARWKGRRLAATSVVTALAGLVVLAVQAPYVT
                     NLVSQPLSPLAYVGLLVGLIAGTSLHELGHAFTLIRYGGRPSRIGIMLFYLMPTFFCDV
                     SDSWRLAERCQRVHVALAGPAVQTFLAGASALAAWPLDVGGVKTCLVLFAVGSYITGLL
                     NLLPLIKLDGYIALMSRVDIPYLRDRAIKDARRSVARLLFGGTYRRELPGRSWTVWYGL
                     ACMTFPLYLLSTALKLWIGLLQRAGFVGACLAASAFCYVLYLVGRGIRRLVGEVRGSGA
                     SRVRVTLVGALLAAAASAVAFLPVTCTTPAAYVTRAGGVDVVLMRGSDASRIEPGRPVS
                     LSTNGLILTPSTGHGVIGQQGGKRTTAPVSAFFPIALGPEPETPVISYRLTTSQAPTEP
                     FGTAEVDTGRLPLWEVAYRTYVAPFIP"
     gene            10001..12520
                     /gene="lanKC"
                     /locus_tag="HYQ63_RS07805"
                     /old_locus_tag="HYQ63_07805"
     CDS             10001..12520
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="HYQ63_RS07805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07805"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_179933174.1"
                     /sec_met_domain="micKC (E-value: 3.6e-191, bitscore: 636.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.9e-11, bitscore: 42.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.3e-07, bitscore:
                     28.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLRFLDFIRQDTFFYDAPDQEDAPDQDFHADRTPAEGWTVARG
                     REWTVCTPPDPGIPGQGWKIHVSALPGNAADLLDVVAPYCVEHDLMYKYINNKAIVARR
                     GSKYGDRTASGKFITIYPPDEQALEKTLTDLDALIGGTPAPYILSDLRWGKGPLYVRYG
                     GFVLLMARARDGQLVPGIRTPDGELVPDERKPSFRPPAWVAIPDFLQDAHRARKQGTLR
                     DFPFRVYKALHFSNGGGVYRAVDARTGSEVLLKEARPLAGLDASGADAIARMEREHWAL
                     QKLAGLPGIPAVVDYRQGHEHRFLAREFIDGRPLVDILRFKHPFASGEDSPAARAAYLT
                     WAMDILKQVEDGVSAMHERGVVFGDLHPGNILLREDGTIAFIDMETCTKPEDGYQQAMG
                     ALGFHAPGHLTGTQVDLFALNVLKLTLFMPLPQVVPWGVEKVHALVDAAAENFDLPVSF
                     TTGVKSVLGRDALRSPQDYSAPWPESGHMPGAAIRDALAASILNAATPERDDRLYPGDA
                     LQFLLPEGGITFAYGAAGVMWALHQCGYEVPAEHVQWLADHARRPLLDGPGFFTGLAGV
                     ACTLHMLGRQGEAAQVMERALTVAEGTDLSLGSGLSGLGLTALHLADREGGNKWLDEGR
                     ALADRITGTSMDHRRAGLIQGRAGHALFLLRLFERTGDERYLDQAVTELRVDLGAIPLD
                     TGDPDGLGLGLAGAAGLALVTREITAYRSGTSLEQTCRWLQEMSRCRLASTNGLFHGRA
                     GSLTVLDRRDPEQMRLHLDAIGWEAVSLEPGRIHTLGEHGYRLSTDLATGSAGVLLALT
                     SLVRDDMHMLPLLPFRSARPVPVGVAA"
     misc_feature    11564..11566
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11789..11791
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12520..13770
                     /locus_tag="HYQ63_RS07810"
                     /old_locus_tag="HYQ63_07810"
     CDS             12520..13770
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.5"
                     /locus_tag="HYQ63_RS07810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07810"
                     /product="YcaO-like family protein"
                     /protein_id="WP_257232579.1"
                     /sec_met_domain="YcaO (E-value: 2e-36, bitscore: 125.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDIPRTLHPSTGVAERYSLQSPQGAGLLWSSAVALHPVPGVPTG
                     EVPPSALIAGARGHSRADVLIRGAGEAVERRALHPLPGLVSYRGTIDSLTLPALDASAH
                     ALAAPHANATVLTWYPARCLRNDTAILVPASLVNWPAIEEEGLFDPSPSGAAAGTTADA
                     ALRSALVEIVERDAFTTAWARQLRLPSWPHPEQALGYAPAGPLRSLWQRALGQAISPVI
                     ARIPTAVPGLCCVVVVLLDPPGPNAMAAVGMKASGRPEQAILGALQEAWQVRAALDETS
                     RTDAPTPEVVVSEHDRIRYLLSPRAYRSVADWAKGFMPGHVVMRSTDVTLRHLTDAVLA
                     DGADPLVVDLTPRLSTHIRGMGWRAVKVIPAGYQGLRMDERHVWTWNLRRVDSAPQRTG
                     CAAGNNDHRAAGPHPLP"
     gene            13795..14685
                     /locus_tag="HYQ63_RS07815"
                     /old_locus_tag="HYQ63_07815"
     CDS             13795..14685
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074697.1"
                     /locus_tag="HYQ63_RS07815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07815"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_179933176.1"
                     /transl_table=11
                     /translation="MLELDKVTRYFGDRAAVERTSFYVEGGRMTGFVGVNGAGKTTTMR
                     LIMGVLAVHDGTIRWDGRPVTADDRRRFGYMPEERGLYPKQTVIGQLTYLGRLRGLSAQ
                     SAQRSAGELIDRLGLAERSTARLEALSLGNQQRVQIAAALIGDPQFLVLDEPFSGLDPR
                     AVDTMVEVLREYIRRGVPVLFSSHQLDLVERLCDDLVFLDRGRVLAQGSAHELRRRGTV
                     RHRLAMSGPTGWLHTFTGVTVISENDEGGGVLLQLDDDGVVDRLLAEALRRGSVREFGE
                     IVPSVSDVFREMTNA"
     misc_feature    14038..14040
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14365..14367
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14682..15923
                     /locus_tag="HYQ63_RS07820"
                     /old_locus_tag="HYQ63_07820"
     CDS             14682..15923
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024110.5"
                     /locus_tag="HYQ63_RS07820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07820"
                     /product="ABC transporter permease"
                     /protein_id="WP_179933177.1"
                     /transl_table=11
                     /translation="MSTSVRDAEARTNPATAHPAQTGARPVGAWRIVTAREIAVKLRDR
                     GFLVSTLVTLALIVGAIGLQVYLASTAGKVTIAATGTRSTQIVRQAQALADRADQDVTI
                     KFHQESSQEAVESAVTSGKADAGLVPSAEGWLLVGDTGIDDTAATWLGAAVQNTAMADN
                     ASNAGTSLGTLTKDSALGHKLLSPESTPESVVRMATFFFGFLFYLAAVMLGVALATSIV
                     EEKQNRIVEIIASSIRLRDLLIGKIVGHTMLALVQMAAFSAAGAIGLIATGHHDVLSQI
                     TVGLSWFLAYYLVGIAVLACVFAAAGAIAGRSEDIQSTTTPVNMVAALVLIAGITASGT
                     AQTVLSYVPLTSTITMPIRIIGGDVSWWEPIVSMLISLFAAAGVVGLSERIYRRALMQT
                     GGKLSFRQALKLTD"
     misc_feature    14805..14807
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15966..16160
                     /locus_tag="HYQ63_RS07825"
                     /old_locus_tag="HYQ63_07825"
     CDS             15966..16160
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYQ63_RS07825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYQ63_07825"
                     /product="hypothetical protein"
                     /protein_id="WP_179933178.1"
                     /transl_table=11
                     /translation="MNSTTARPATVIASLLAVMCGAMIVVITSSLGDTARYALGAALLI
                     GIATGAYKLSQALKENRTR"
     misc_feature    complement(16167..16176)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            16240..16479
                     /locus_tag="HYQ63_RS07830"
                     /old_locus_tag="HYQ63_07830"
     CDS             16240..16479
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYQ63_RS07830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYQ63_07830"
                     /product="hypothetical protein"
                     /protein_id="WP_179933179.1"
                     /transl_table=11
                     /translation="MEHRIRITSIDPASPETASVRLVAKLPPTWRLKQIKCTPDPAIAE
                     LTLDIPSDFEVGDVGQTVDAILTTPGLEGWARFY"
     misc_feature    complement(16258..16272)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.88"
                     /tool="antismash"
     gene            complement(16660..17664)
                     /locus_tag="HYQ63_RS07835"
                     /old_locus_tag="HYQ63_07835"
     CDS             complement(16660..17664)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005314895.1"
                     /locus_tag="HYQ63_RS07835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07835"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_257231711.1"
                     /transl_table=11
                     /translation="MSETIHPDQEDTAGACLGILGVSAAEEALYRRLLRSGNGCVSATC
                     LVSGEEVLADRLVELGVAVRGGLAGGVRAVGPARAVDQLIDDRLRRLRGELEAAIAATG
                     VVESLISEMAGSHSSPVDVPPVQQLKGTAAVREAIDELTFFARSENLTVNPIGVLTPES
                     IEASRPMDLRVLRRGLRMRTLMAAPALDDPATMAYLRELAAKGAEIRISYQPLERMIIC
                     DRSAALTPIDPSRTARGALLTRETGLVATLVALFERMWVSAQELPLEDEDAPSETECSV
                     LKVLYTADKDESGARDLGMSVRTYRKYVASLMDRLGASNRFQAALLARERGWI"
     misc_feature    complement(17338..17340)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17461..17463)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17494..17496)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17876..17891
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.61"
                     /tool="antismash"
     misc_feature    complement(18105..18125)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     gene            18270..>18777
                     /locus_tag="HYQ63_RS45920"
                     /pseudo=""
     CDS             18270..>18777
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059485.1"
                     /locus_tag="HYQ63_RS45920"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIVSLVCQVMRKLLSVPVVLLRRQTSRDAELLVLRHENAVLRRQL
                     ASPVRYQWADRLWFAALSSLIPRRRWAQVFPVTPGTLLGWHRRLVARRWDDSECRSRPG
                     RPATAESVKELVLRLTRENPRWGAAGSRGSSSSPGLRAGFPRARHTPPPHRRGDHASGR
                     TVDGPA"
     misc_feature    19004..19017
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.57"
                     /tool="antismash"
     gene            19133..20244
                     /locus_tag="HYQ63_RS45575"
                     /pseudo=""
     CDS             19133..20244
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059395.1"
                     /locus_tag="HYQ63_RS45575"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="integrase core domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGLRLLYLIFCRLLGCLLLLGRSTAANHAEILVLRHEVAVLRQQV
                     ERPRFSWADSAVLSALARHLPSVLRRHRLVTPGTLLTWHRRLVRWKWRQTAVGPGRPPL
                     PEETVALIQRLARENPTWGYVRIQGELRRLGHRVAAATIRRVLHRLGLPPAPQRASSRP
                     GVPSCAHRPTRYSPATSCTWRPSSSSASMSSSSWRSPPGASMSWASPPTRPAHGPPNSP
                     ATCSWTSRTEPGASGSSFVTGTASSPPHSTPSSPATAQPSSRLRHKAHGPTRSPNDGYA
                     QPAPSAPTDS"
     misc_feature    19181..19183
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19337..19339
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20120..20122
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20366..21458
                     /locus_tag="HYQ63_RS07850"
                     /old_locus_tag="HYQ63_07850"
                     /pseudo=""
     CDS             20366..21458
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719271.1"
                     /locus_tag="HYQ63_RS07850"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_07850"
                     /product="integrase core domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLLRLAYLAATNALAFLRLLPMSDREKDVEILVLRHQLLVLQRQV
                     GKPSFTDSDRAVLAGLLHHLPKDRLRHLLLLVRPETVLHWHRELLRRRHAATCVPRRRG
                     RPRTLRSIRALVLRMARENASWGYRRIHGELAALGIKVAASTVWEIPREHGIPPAPERQ
                     STTWADFLRSQAKALLACDLFEVRTLTGARLYVFAVIEHTTRRIRILGANAHPTGDWIV
                     QLGRNLLMDLEDADSRARFLIHDRDSKFTTAFDALMADAGLKVVTTGIRIPRMNSLIER
                     WIKTCRTELLDRTLIWNQSHLLRALREYESFYNEHRPHRTLKNAAPCRPTTHPHHPTSP
                     AHPPGNPQTRPARRNAPPAPARRL"
     misc_feature    complement(22018..22030)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
ORIGIN
        1 gcgtttgctg ccgatgagtg gccgggacaa ggatgtagag atcctggtcc tgcgccatca
       61 gatcgcggtc ctggaacgcc aactcggcaa gggcaaagtc cggttcagct caagcgaccg
      121 ggcgttcctg gcggcgctgc tgcaccggct gccgttaccc gccctgcggc gggtgcggct
      181 gctcgtgcgt cctgacacgg tgctgcgctg gcatcgcgac ctcgccaggc gccggcatgc
      241 cgccttatcg cggcccaagc gacccggccg acctcgtacg gtgcgctcta tccggattct
      301 ggtactgcgt ctggcgaggg agaatccaaa ctggggctac aggcgtctgc acggtgagtt
      361 gctcgtactc ggcgtgaagg tgtccgcctc gaccgtctgg aagatcctca aggacgcggg
      421 cgtcgatcca gcgcccgacc ggagttccag cacgtgggcc gacttcctgc gctcccaagc
      481 cgacgccctc ctggcctgcg acttctttga gacggtcacc ttgtccggca cgcggatgta
      541 cgtactcgcg gtgatcgaac acagcagtcg ccgcctccgg atcctgggcg ccaccgcaca
      601 cccggcagcc tcctgggtaa cgcaagctgc gaagaacctg gtcatggacc tcgaggacgt
      661 cggctgccgg gcacggttca tgatcccgga cagggacggg aagttccccg ccctgttcga
      721 cgctgtcctc aaggacacgg ggatcgaggt cgtcctcacc ggcatccaga taccgagaat
      781 gaactcaatc atggaaaggt gggtgcagac ctgcagacac gagctcctgg accggaccct
      841 gatctggaac cagcgccacc tcctccacgc cctacgagag ttcgaggagt tctacaactc
      901 ccatcgaccg caccagggca tcgcgaacgc ccgaccgcta cacccactgc ccacaccaat
      961 caacgatccc gaaaagctaa gccagctcga catacgacgc cacgaccgcc ttggcggcat
     1021 cctccacgag tacagacatg ccgcgtgacc tgcacggatt aagtattcgg caagcacagg
     1081 agcaggtggc cgtaaaggtt gaccgtggtg gccagtgtcg agtggcgcag cgtcttggag
     1141 atcacggcca gcggcacccg tgagctgatc atgatggtgg cggccgtgtg ccgcaggtcg
     1201 tgcacgccga tccgcggtag accgagctca gcggcgcgcc gccgcagctc ggcaagcacc
     1261 ccttgtggac gcaaggggga gccgtccggc tggcagaaga cccggtgtca cccccgtcac
     1321 cgaacgcgcc gagcggatcg tcgccaagcg gggcgcgaac gcggcgctcc acgaacgtgt
     1381 acgggccggg acttccggtt tgccgtgacg ggcgtcgaag cccgcggcac cttgcgtatc
     1441 gaggtcgccg acacccgtgg cgagaagccg aagcagccgg tgcattgggc tccctgttcg
     1501 cctggaaagg ctggaagctg ccgtgcacct tgtacgtagc ggtcgcgcaa cggtccggcg
     1561 cggcattacc gactcacgct gcgcagcgca tcggtcaccg ttctgatgcc gtttcctgca
     1621 ctgtcctggt tccggaagct gcacggtttt tatctcgttt gagggcttgg cagcggccag
     1681 agttgacctt gcaagaacga gaccgaagac acgagaccac gtaatgtgcc catcaggggg
     1741 gaacatcgtg aacagcaaca aagtggtgag aaccttacgc cgttcctcgg caacgtttct
     1801 ggccggtgca atgctcgccc tcgcggccca cggcgtcacg tacgccgccg acggtgcgtc
     1861 ggccccgtgg cccggccgcg cggtcatcgc tccggtagac ctgccctttc cggccatcga
     1921 gcctagccgg accaacgact ggggctgatc cggttcagcc ttcctgaccg ttgagtgtct
     1981 gccgagaaac agaagaggct cccgccgtga ctgagctgtc agttctcatc ccgttcgttc
     2041 ctcgccgtct ggagcaggtg ctgccgttcg ccggcctggt caattggact agcgcggcgc
     2101 ggctgtggca gggccagtcg atggtgctcg aaccgcatca gacattcgtc ggtgtggcgg
     2161 gggcgggctt cagggttccg gctgggctag gggtgacact gatgccgctg aggaacccct
     2221 tcgaagcagc gacgcaggcc cgctcggtgg cgctggccac gggacatccg gtcaccgcgg
     2281 gattcgggac cggagccgtg cagttccagc ggaacatcct tggctccgcc tactccagcc
     2341 cgctcaacac ggcgcgtgct tacgtcaccg ccgtgcgcag cctgctggat ggtgaactgg
     2401 tgcagagtga cgggacggaa ttcaccctga ccggccaact tcccccggcg gtggcccctc
     2461 gggtcgatgt ggggctcggt gtgctcaggc caggcatggc ccgtctcgcc ggtgaggtcg
     2521 cggatgccgt catcacctgg ctgaccccgc cgtcctatct gaaggacgtg ttggttccag
     2581 cggtcgcgga agggatgaag aaggcaggac gcacccgtcg gccgaggatt atcgcgatgg
     2641 tgcccgtagg ggtgaggcgg gacgagaccg atcccgagcg gttggcgctg gcgagtaacc
     2701 tcgcccacct ccaggcaccg cactaccagg acatgctccg ccgggccggc gcggacatcg
     2761 gcgacggcaa cgacgtgcac caggcggcgc gcgcagtggt cgacaccggg gggttcgtca
     2821 ctggcgatct cgatgatgtt ctcaagggtc tggacgcgta ccagcaggcc ggagccgacg
     2881 agatcgtcct gaacaccacg ggtgtcaaca agatgttcgg ctctcccgag gccctggctg
     2941 acctccgcac cattctcaag gcgcaccagt agagcttcag ttgcccgccg gggccctgtt
     3001 tcgagaggtt ctttgatgga caccatcgcg cgcagacgcg cgaaacagca catcatgtcg
     3061 tggggctcgg gccatgtccg cccggaccgg gttcctgccg ggcaggcagc cacggttgtc
     3121 ctcgccaacc gcgcccacct cgatgacgcc gtatcctccg gcgtcatcgg agactccacc
     3181 gtggcctttg ccccccgaac cagtgatggc cccgtcgtgg gctatgacgg ggcgctcgac
     3241 gaacccggca cggaactcgc tctcggacac gacttctacc tccagacgca ggactacgcc
     3301 tccagcgcct acatgacggt cctcggtccc accatcgtcc gcctcttcac gaacgaggac
     3361 ttcgccgcct gtctgcgcga cgccgaccgt gcgctcgagg agggcgcctt ccccgagttt
     3421 ctgatcacgc cgtccgtgct gctcgcggac acatccggtc tcggcggcgg cccggcgggc
     3481 gacggcccgc tgacgaggtt gtacgcggac cgcgccggga actggtcgac ctcgccccga
     3541 ggagccgttc tgggcacgat cggcgacagt ctcgacacgc tgatagcccg ttacgaggag
     3601 atcaacgccg caagcccggc gccgtgcgct gttgccttgg ccgcagtgat cagcgatccg
     3661 gaccgctctg cggctctccg ggaacgcccg tatctgggac gctacctcgc ggcggtacgt
     3721 gccctgcgct cggtgatcgc ccggggtgcg cacgagccga aggtatccgg gttcggcgta
     3781 cggctcgtcc ccggcctcgt cctggaaggg ccggacgtca cggacgccga ggctccgctg
     3841 gtgatgttca ccgaagaaga ggcgtatgtc tccgccgcag ggcggctgtt cagcgtcagc
     3901 cgcgacgtcg ccggggccgt cgaatgcctc ctggccgggg cagccgatcc ggactctgcc
     3961 gaacggttgt cgcaggtgcg cgactacttc acccagcagg gcgtcccgct ccccgagccc
     4021 gtggtggtgg cgtgatgact cctgtggcca ctccctttct accgggccaa gccggtgagc
     4081 gcgtcgcgca gctcggtgac cgggcacgcc tgtgcggcct gtacgacgaa gacggatccg
     4141 gcgtgtacga cgatctcgca gcggcggacg gcttcgagat ccgagacatc atcatcgcag
     4201 ttcgaaccct tgacggaccg gtgctggact tggccgccgg ctccgggcgc ttcaccctcc
     4261 cgctgctggc actcggccgc gatgtgacgg cactggacat gtctccgcac atgctcagcc
     4321 tgctcactca gcggctcgcc agaacacctg agcgggtgcg cgagcggtgc accgtggtgc
     4381 aggcagacat gtctggcttc accctgaggc agcgtttcgc ccacgtcctg cttggcacca
     4441 cttcactgtc cctattggat tcatctggcc gggctggcct ctaccggtgt gtcgccgaca
     4501 gtctcagcga aggcggccag ttcctggtgt cggttctgga gcgtggcggg gacggcgacc
     4561 cggacgaagt cgttcagcgt gcccacggtg ccagcggtac cccgtacgac ctgtacgagt
     4621 actggccgac gggcgcctcc caccgtacgg tcaccatcgt tcccgctgat ccgccgccca
     4681 ccggacacgt ggtcgtggca catgacgagg ttcccagcat gagcatctcc accatcgaga
     4741 gggaacttca tcaggccggg ttcaccgcgc tcgaccagcg ggagctgacc ccggtcgggc
     4801 aacggcaccg tgtcgttctg atcaaggcgg tgcgcgcatg accgggaaca tcctgtggcc
     4861 ctacctgatc gctccctcgg cgcacggcag tgaccggcag tgcgcggtgc aggccgcagg
     4921 ccaccgcatc accttcgcgg acggcagcac ggtcctcgac ggcgacagcg gcctgtggaa
     4981 cgccaacctc ggctacggca acccagtgat cgcggatgcc atcggcgagg ccacgaggga
     5041 agcctcctac ctgggtgcgt tcagattcga gaacagttac gcccgcggtg ccgcaaccga
     5101 tctgctcgct gtagctgaca ccgaaaacta cgcacgcgtg ttgttctcgt ccggcggcgg
     5161 cgtcgccaac gacgcggcga tgaagctggt gcgccaatac catgccctcg acgggcaccc
     5221 ggagcgcaac ctgatcgtcg ctctgcgcgg tagcttccac ggcctgacat tcggcgggtt
     5281 cgccttgacc ggcgaggagt tgggccagcg tgtctacggt gtcgatcagc gcctgatccg
     5341 gcacatcaat cccaacgaca tcggcgagct gcgcgacctc atccagcgca tcggccgtca
     5401 ggttgccgca ctcgtggtcg aacctgtcct gggtaccgga acgatcccgc tcggcgcgga
     5461 ttacatcgag gaactgcttc ggctgcgcga tcggtccggg ttcctgctcg tcgcggacga
     5521 ggtggcgacc ggcttcggcc gcaccggcag ctttttcgcc tctcacacct ggccgggccg
     5581 accggacgtg ttgatcacct cgaaggggct gacgaacggc acgatgcccg cgtcggcggt
     5641 catcttctcc caccaggtcg cggagatttt cacccgccac gacgccattc tcacgcacgc
     5701 ggagacccag ggcggaacgg ccgtctcgtg cgccgcgatt cgcgcgacga tcaacgagat
     5761 gcagcgactc gatgctgtcg tctcgggtcg gcgtgtcgcc gaccgcctcg ccgctcgcat
     5821 cgatgagctg gtggatcagc atcctctggt gaatcactcc accgggcagg gctgcttccg
     5881 aactctgcac ctgcggggtc ccggtgggca ccgcctcgca ccgcccggtg tcgcatggct
     5941 cgtcggccgc atccgcgacg agggcgcaat cgtgcacccc ggaccctctg gcatccagct
     6001 cgtccccgct ctgacgtgga ccgacgcgga gacggacgaa ctgatggcct gcgtccagac
     6061 gggcctgaat gccctgaccg ccgtcgccgc acgccactga gcgggaccag ccttcgcctc
     6121 gaagactcca gaacctcgcg ggttctggct accccaaccc gacccctgtg gagaggagga
     6181 gagcaacatg accgaccgca atcttgctga ggagccgcag atcgacgcct gtgagctgga
     6241 gatgcaggag ctggaggccc tggaggcccc gggcttctgg accggcgttt cgatcggcac
     6301 cgtggtcagc gtgtccgtcg tcgcggcgac ctgacgccgc catctgtttc gcacaggttg
     6361 tgcctcggcc cgcgcccacc ggccgggccg ggcgcagccg tcctctccct gagcaccctt
     6421 tcacggcctt ccgttccggc aaggagacga tattgatgtc cgacaccgcc gcgcgagctg
     6481 ccaggcaggc gttcacgctg ccagccgcac cgctgcggtc catcggctcc cttgccgagt
     6541 ggctgcgcgg tgacgaggcc gatgccgtca ccatgatctg cgatcctgcc ctcaccgggc
     6601 agcccgtcac cgtaggcgtg cgcgaccaaa tccgcagcgc gggcatcacc tccagggtgg
     6661 tgaccctccc gatcaaccgg gatgccgagg cgatccggtc gctggctgcc cggctcgcgc
     6721 cgcgcgaact ggtcgtcgcc atcggtggcg gcagcaccct cgactttgcc aagctcaccg
     6781 cgctgtcagc cattcagccg gacatttacc gctacctcac cgcgccgcag cgcagcggat
     6841 ttctcctcct gccaccccac cttggcaaca gcgtacgagt cctggccgta cccactactt
     6901 tgggcaccgg gagcgaactg ggcaccgtgg cctgtttcga acgcgccggc cacaagctct
     6961 tggtcaccgg atcatgcttg cgtccggtcc aagcgatgtg gattgcggag gccaccgaca
     7021 cgctgcccgc cgacctggtt gccgacggcg tcctggaggc actgttccgc accgtcagcc
     7081 cctacaccgg tgacccggcc cccttgccgg agcaggatgc cgctgtcgaa gaccttgccg
     7141 tacgccttat ccaggcgggg gacgaggtcg cccgcctgcg cgccgcgggg aatccgattc
     7201 ccgcggatct gcggctgcgt atcgcagaga tgagtgcgca atcccagatt ggccacctca
     7261 atatcggccg cagcccctat gccgtgaagt gctggtgcat cgccaacgag ctctcaactt
     7321 tgctgggact ggccaagatg cgcaccgtgt ccgccgtgtg gcccgtgctg tggcggcact
     7381 gcctggccgg gaacgaccgg ctcggcagcc ccgaccggat cctcagcctg tggacagtga
     7441 tccgcggcac cttcccacac ttcggccagg atccggtcac tgggctggaa cggctgatgg
     7501 acgcctggcg catcgaacgc accgtgcacg ccggcacccg tcaggtcgag gagaccaccg
     7561 agcggatcat gcgcgcatgg ggggccggcc tgcccatcct cgacggcgtc cgcgcgcagg
     7621 aaattcgccg actcctcacg gacgccacct actcgactgc cgacggtgtc gtgtccccgc
     7681 ccggcaccgt cggcccacca gaccaccgca cgcccacgga accagaccgt gtgcatgcgg
     7741 aggaacacac catccgagcg caccaggcgt gatcacaccg ggtgccgcgt aaaaggagaa
     7801 gttcatggac cacatcgagg tcgagcttca gaacctgacc atctcggagc tggagatgca
     7861 ggagctggag gccctggagg ctccgggctg ggcgaccagc gccggtgtca gcgtcggcat
     7921 ctccgtcgtc tccgtggcct ggagcctcac ctgaaccctg caccctgcct cgcgccttcg
     7981 ggcgggccgg gtacagcgcg gccgtgtgcc gcatcccact catccacctc tcacgaagga
     8041 gaaccctccg atggagaaca tcacgaacga agccccggcg ctggagctgg agatgcagga
     8101 gctggaggcc ttggaggccc ccggattctg gaccggcgtc tcgatcggcg ccaccatctc
     8161 ctccgcggtt ggcacgtcga tcgccctcac ctgatcaacg gtgaccgccg ttcggtgagc
     8221 gtccctgcgc tcaccggatc tccggagaaa ccgtagacgc tgcctccgcc ccgctcctga
     8281 gccaggggcc gggcggaggc ggggcacagt gccgcccttt ctctgtacat tccgaggagc
     8341 caccaccgtg agcactacca ccgcgccggt cctgccggac gcgcagcggc cccggctcgc
     8401 accgggcata gaggtccacc cgcccatggg cgacggtggc tcctgggtca tccagcatgg
     8461 cccccgctac atccgggtca gtgcctccgt cgcctccctg gcccagcgcc tggacggcga
     8521 gaccacgatc gatgccctcg ccggatcgat gggcgtcccg tggaccgcgg aactggtcac
     8581 tgatgccgtt ggtcgtttcg acgcgctacg tctgctcgac cgcggtgagc agacgccgaa
     8641 aaagaagcag cgctcgtccc gcatcaagtt ggtgccgccg ttcaccgtgc agctcacgct
     8701 gctcagcccc ggtcggacga tgcaggccct tcagccggcc ctggcccgct ggaaggggcg
     8761 ccgactcgcg gccacttccg tcgtgaccgc cttggccggt cttgtcgtgc tggctgtaca
     8821 ggctccctac gtgaccaacc tcgtgtccca gcccctgtct ccgctggcct atgtgggtct
     8881 cctcgtcggg ctgatcgccg gtacctcgct gcacgaactc gggcacgcct tcactctcat
     8941 ccgctacggc ggtcgcccgt cccgtatcgg gatcatgctg ttctacctga tgccgacgtt
     9001 cttttgcgac gtctcggact cgtggcggct tgccgaacgg tgccagcgcg tccacgtcgc
     9061 cctcgccgga cccgcggtgc agacgttcct cgccggagca tccgccctgg ccgcgtggcc
     9121 gctcgatgtc gggggcgtga agacgtgtct ggtgctgttc gccgtcggca gctacatcac
     9181 cgggctgctg aacctgctgc cgctgatcaa gctggacgga tacatcgcgc tgatgagccg
     9241 cgtggatatc ccctacctgc gggacagggc gatcaaggac gcacgccgca gcgtcgcacg
     9301 tctgctcttc ggcggtacct accggcggga actacccggc cgcagctgga ccgtctggta
     9361 cgggctagca tgcatgacct tccccctgta cctgctgtcg accgcgctga agctgtggat
     9421 agggctgctg cagcgtgccg ggttcgtcgg tgcatgccta gctgcctcgg ccttctgcta
     9481 cgtgctctat ctcgtcggcc gtggcatcag gcgcctggtg ggagaggtgc ggggctccgg
     9541 agcctccagg gtgagggtca ccctcgtcgg cgccctgctc gccgccgcgg cttccgcggt
     9601 ggcgttcctt ccggtcacct gcacaacccc ggccgcctat gtcacacgcg ccggcggagt
     9661 cgatgtggtc ctcatgcggg gctcggacgc gagccgcatc gagccgggcc gacccgtgtc
     9721 cctgagcacc aacggcctga tcctcactcc gtccaccgga cacggggtca tcggccagca
     9781 gggcggaaaa cggacgactg ctccggtgtc ggcgttcttt cccatcgcgc tcggtccgga
     9841 gcccgagacc ccagtgatca gctaccggct cactaccagc caggccccca ctgagccgtt
     9901 cggaacggcc gaggtcgaca ccggacgctt gccgctgtgg gaggtggcgt accgcactta
     9961 tgtcgccccg ttcatccctt gagatttttg aggccctgcc gtgaccgatc ttcgctttct
    10021 cgatttcatc cgccaggaca ccttcttcta cgacgcaccc gaccaggaag acgcgcccga
    10081 ccaggacttc cacgctgacc gcacccccgc cgagggatgg accgtggcgc ggggccgtga
    10141 gtggaccgtg tgtacgcctc cagatccggg catccccggc caaggatgga agattcatgt
    10201 ctcggcgctg cccggcaacg cggccgacct gctggacgtg gtcgccccgt attgcgtcga
    10261 gcacgacctt atgtacaagt acatcaacaa caaggcgatc gtggcccggc ggggaagcaa
    10321 gtacggagac cgcacggcaa gcggcaagtt catcaccatc tacccgcccg acgagcaggc
    10381 cttggagaag accctcaccg acctggacgc gctgatcggc ggtacccccg cgccctacat
    10441 ccttagcgac ctgcggtggg gcaaggggcc tctgtacgtg cgctacggcg ggttcgtgtt
    10501 gctgatggcc cgcgccaggg acgggcaact cgttcccggc attcgcaccc ctgacgggga
    10561 gctggtcccg gacgagcgca aaccctcgtt ccgcccgccc gcgtgggtgg cgatcccgga
    10621 ctttctccag gacgctcacc gggctcgcaa gcagggcacg ttgcgagact tcccgttccg
    10681 cgtgtacaag gcgctgcact tctccaacgg tggtggcgtc taccgtgccg tcgacgcccg
    10741 cacaggcagt gaagttctgt tgaaggaagc ccgcccgctg gccggcctgg acgcctccgg
    10801 cgccgacgcg atcgcccgga tggaacgcga gcactgggct ctgcagaagc tcgccggcct
    10861 gcctggcata ccagcggtgg tggactaccg tcaggggcac gaacatcgtt ttttggcaag
    10921 ggagttcatc gacggccgcc cgctggtcga catcctgagg ttcaagcacc cattcgcctc
    10981 gggcgaggac agcccggccg cacgtgccgc ctacctgaca tgggcgatgg acatcctcaa
    11041 gcaggtggag gacggcgtat cagcgatgca cgagcggggc gtcgtcttcg gcgacctgca
    11101 ccccggcaac atccttctcc gcgaagacgg caccatcgcg ttcatcgaca tggagacctg
    11161 caccaaaccg gaggacggct accagcaggc gatgggcgcg ctcggtttcc atgcccccgg
    11221 ccacctcacc ggcacgcagg tggacctgtt cgcgctgaac gtcctgaagc tgacactgtt
    11281 catgccgctt ccgcaggttg tgccgtgggg cgtggaaaag gttcacgccc tcgtcgacgc
    11341 agcagccgag aacttcgatc tccccgtgtc tttcaccacc ggggtgaaat cggtgctcgg
    11401 ccgcgacgcc ttgcgctccc cccaggacta ctcagcgccg tggccagagt ccgggcacat
    11461 gcccggtgcc gcgatacgcg acgccctggc cgcttccatc ctcaatgcgg caacccctga
    11521 gcgtgacgac cgcctctatc ccggtgacgc gttgcagttc ctgttaccgg aaggtggcat
    11581 caccttcgcc tacggtgctg ccggagtcat gtgggcgctc caccagtgtg gctatgaggt
    11641 cccagcagag catgttcagt ggctcgccga ccacgcccgg cgcccgctgc tggacggccc
    11701 cggcttcttc accgggctcg ctggagtcgc ctgcacgctc catatgctgg ggcgacaggg
    11761 cgaggccgcg caggtgatgg agcgcgcctt aacggtggcc gaaggaaccg acctgtcgct
    11821 gggttcgggc ctgtctggtt tggggctcac cgcgctgcat ctcgccgacc gcgaaggcgg
    11881 taacaaatgg ctggatgagg gccgtgccct ggccgatcgc atcaccggca cgagtatgga
    11941 ccaccggcgt gcgggcctga tccagggccg tgccggacac gccctgttcc tgctgcgctt
    12001 gttcgaacgc accggagacg aacgctacct ggatcaggcg gtgaccgagc tgcgcgtgga
    12061 tctcggcgcc atcccgctcg acaccggcga tccggacggt ctcggtctgg gcctcgcggg
    12121 cgccgccggc cttgccctcg tcacgcgcga gatcaccgcc tatcgctccg gcacgagtct
    12181 ggagcagacg tgccggtggc ttcaggagat gagccgttgc cgtctggcct cgacgaacgg
    12241 attgttccac ggccgcgccg gttccctcac cgtcctggac cggcgtgacc ccgagcagat
    12301 gcggctgcac ctggatgcta tcggctggga agccgtctcc ctggagccgg gccggatcca
    12361 cacgctcggc gagcacggct accgcctctc caccgatctg gccaccggat ccgccggagt
    12421 cctgctcgct ctcacctccc tagtccgcga cgacatgcac atgctgccgc tccttccttt
    12481 ccgttcggca cgtccggtcc ccgtgggggt ggcagcgtga tgctcgacat cccccgtacc
    12541 cttcatccct ccaccggtgt cgcggagcgg tactcgctcc agtcaccgca gggcgcgggc
    12601 ctgctgtggt ccagcgcggt cgccctccac ccggtgcccg gcgtgccgac gggagaggta
    12661 ccgccctcgg cactcatcgc gggagcccgc ggtcactcac gcgccgatgt actcatacgt
    12721 ggcgcgggcg aggcagtcga acgccgtgcc ctgcatccgc tgcccggcct ggtctcctac
    12781 cggggcacca tcgattccct cactctgccg gcgctggatg cgtctgcgca cgctctggcc
    12841 gccccacacg ccaatgccac ggtgctgacg tggtatccgg cccgatgtct tcgtaacgac
    12901 acggccatcc tggttcccgc cagtctggtg aactggccgg ccatcgagga ggagggcctg
    12961 ttcgatccga gtccgtccgg agcggctgcc ggaaccaccg cagacgcggc tctgcgctcc
    13021 gccctggtcg agatcgtcga acgcgatgcc ttcaccacag cctgggcacg gcagctgcgc
    13081 ttgccgtcct ggccccaccc ggaacaggcg cttggctacg cgcccgcggg cccgctccgt
    13141 tcgttgtggc agcgcgctct cggccaagca atcagcccgg tgattgcgcg gatccccacc
    13201 gctgtacccg gattgtgctg cgtcgtggtc gtgctgctcg acccgcccgg tcccaatgcg
    13261 atggcggcgg tcggcatgaa ggcatccgga cggcctgagc aggcgattct cggcgccctg
    13321 caagaggcat ggcaggttag ggctgctctc gacgagacgt cccgcaccga cgctccgaca
    13381 ccggaggtgg tggtcagcga gcacgatcgg atccggtacc tgctcagccc gcgggcgtac
    13441 aggtccgtcg cggactgggc aaaggggttc atgcccggcc atgtggtgat gcgttccacc
    13501 gacgtgacac ttcggcacct gaccgacgcg gttcttgccg acggcgcgga tccgctggtg
    13561 gtcgacctaa ccccccgctt gtccacgcac atcaggggca tgggctggcg ggccgtcaag
    13621 gtgatcccgg cgggatacca gggcttgcgc atggacgagc gacacgtatg gacgtggaac
    13681 ctccgccggg tggacagcgc accccagcgc accgggtgcg cggcagggaa caatgaccac
    13741 cgggctgcgg gaccgcaccc cctgccctga ctcgcaacga cgaaagcgac agtgatgctg
    13801 gaactggaca aggtgacgcg gtacttcggc gaccgtgccg ccgtcgaacg gacctccttc
    13861 tacgtcgagg gaggccggat gacgggcttc gtcggcgtga acggggccgg gaagaccacc
    13921 accatgcgct tgatcatggg tgtgttggcg gtccacgacg gcacgattcg ctgggacggg
    13981 cgtccggtca ccgccgacga tcgcagacgg ttcggttaca tgcccgaaga gcgcggctta
    14041 tatccgaagc agaccgtcat aggacagctc acctacctcg gccgactgcg cggactgtcc
    14101 gcgcagtcgg cccagcggtc ggccggcgag ctgatcgacc ggctgggcct ggcggagagg
    14161 agcaccgccc gtctggaggc gctgtcgctg ggcaaccagc agcgggtcca gatcgccgcc
    14221 gccctcatcg gcgaccccca gttcctcgtg ttggacgagc cgttctccgg tcttgacccg
    14281 cgcgcggtgg acacgatggt cgaggtgctg cgcgagtaca tccggcgagg ggtgccggtg
    14341 ctgttctcct cgcaccagct cgatttagtg gaacggctct gcgacgacct ggttttcctg
    14401 gataggggca gggttctggc gcagggatcc gcgcacgagc tgcggcgtcg cggcactgtt
    14461 cggcaccgtc tcgccatgtc cgggccgacc ggctggctgc ataccttcac cggcgtcacc
    14521 gtcatcagcg agaacgatga gggcggtggt gtgctgctgc agctcgacga tgacggcgtg
    14581 gtcgaccggt tgctggccga ggcgctgcgc cgcgggagcg tacgggagtt cggcgagatc
    14641 gttcccagcg tgtccgatgt tttcagggag atgacgaacg catgagcacc tctgtccgcg
    14701 acgccgaggc ccgcaccaac ccggccacgg cccatccagc acaaaccggt gcacggcctg
    14761 tcggtgcatg gcgtatcgtc accgcccgcg aaatagctgt caagttacgt gaccgggggt
    14821 tcctcgtctc caccctggtc acgctggccc tgatcgtcgg ggcgatcggt cttcaggtgt
    14881 acctggcctc caccgccggg aaggtcacca tcgccgccac gggcacccgc agcacacaga
    14941 tcgtccgcca ggcccaagcg ttggctgacc gggcggacca ggatgtgaca atcaaatttc
    15001 accaggagtc ctcccaagag gccgtggagt cggcggtgac ctcagggaag gcggacgccg
    15061 gcctggtccc ctctgccgag gggtggctgc tggtgggcga caccggcatc gacgacaccg
    15121 ctgccacctg gctcggcgcc gcggtgcaga acacagccat ggccgacaac gcctccaatg
    15181 ctggaacgag cctgggcacg ctcacgaagg attcggcgct cggtcacaag ctgctctccc
    15241 cggagagcac gcctgagagc gtagtccgca tggccacgtt ctttttcggc ttcctgttct
    15301 atctcgccgc ggtgatgctc ggcgtcgcgc tggccacgag catcgtggaa gagaagcaga
    15361 accgcatcgt cgaaatcatc gcgtcctcca tccggctgcg cgacctgctc atcggcaaga
    15421 tcgtcggaca caccatgctc gctctcgtgc agatggccgc gttcagcgcc gcgggcgcca
    15481 taggcctgat cgccactggc caccatgatg tgctgtccca aatcaccgtt ggcctgagtt
    15541 ggttcctcgc gtactacctg gtcggcatcg cggtgctggc ctgtgtattc gccgcggcag
    15601 gggcgatcgc cggccgcagc gaggacattc agtccaccac caccccggta aacatggtgg
    15661 ccgccctggt cctcatcgca gggatcaccg cctcgggcac cgcgcagacc gtcctgtcct
    15721 acgttccgct cacgtcgacg atcaccatgc cgatccgcat catcggcgga gacgtctcct
    15781 ggtgggagcc gatcgtttcg atgctgatat cgctgttcgc cgcagccgga gtggtggggc
    15841 tcagtgagcg aatctaccgc cgggccctga tgcagaccgg cggaaagctg tccttccggc
    15901 aggccctcaa gctcaccgac tgatcagccg cctttcccca accttccact gaaggagacc
    15961 gaaagatgaa ctccaccaca gcccgccccg ccaccgtgat cgccagcctg ctcgccgtca
    16021 tgtgcggggc catgatcgtg gtcatcacca gcagcctcgg cgacaccgcc cgctacgccc
    16081 tcggcgccgc cctgctgatc ggcatcgcca ccggcgccta caagctctcc caggctctta
    16141 aggagaaccg cacccgttaa caacagcgcc gccttcgtca cggggccgca ccccttctgg
    16201 cccctgacga agccattcct catgggagtc ccgccgtcca tggagcaccg catccgcatc
    16261 accagcattg atccggcctc tccagagacc gccagtgttc ggctggtcgc caagctgccg
    16321 cccacgtggc ggttgaaaca gatcaaatgc actcccgacc ccgcgatagc cgaactcaca
    16381 ctcgacatcc cgagcgactt cgaggtgggc gatgtggggc aaaccgtcga cgcgatcctc
    16441 accacccctg gcctggaagg ctgggccagg ttctactgag gtcaaactcg tgatgtcgca
    16501 ggggctgacg gccgggattt acgcgcggta tcaccagggg tattcgggca gaaatgtcga
    16561 cgtacaacgt cctgatcgac atcatggcca tgggcaagaa gtttcgcgcc caaactcata
    16621 tcgtggcccc gaactgggtg aaccttgcct gatgcggcac tagatccagc cccgttcgcg
    16681 ggccagcagg gcggcctgga accggttcga ggcgcccagt ctatccatca gtgacgccac
    16741 gtatttgcgg taggtgcgca cggacatgcc caggtcacga gcaccgctct cgtccttgtc
    16801 cgccgtatac aacaccttga ggacactgca ctcggtctca ctgggcgcat cctcgtcctc
    16861 gagcggcagc tcctgcgcgc tgacccacat ccgctcgaac aaggcgacca gcgtggcgac
    16921 caagccggtt tcacgcgtca gcagagcacc cctggccgta cgggaggggt cgatcggggt
    16981 gagagccgca cttcggtcac atatgatcat gcgttccagt ggctgatagg agatgcgtat
    17041 ctccgcgcct ttcgcggcga gttctcgcaa gtaggccatc gtggccgggt cgtccagggc
    17101 cggagcggcc atcagggtgc gcatgcgcag cccccgtcgc agcacgcgca gatccatggg
    17161 acgggaggcc tcgatggatt caggggtgag cacgcctatt ggatttaccg ttaggttctc
    17221 cgaacgcgcg aagaaggtga gctcatcgat ggcctccctt accgccgccg tccccttcag
    17281 ttgctgaacc ggcggaacgt ccacgggcga gctgtgcgat ccggccatct cggagattaa
    17341 cgactcgacc acgcccgtgg ccgctatggc cgcctccaac tccccccgca gccgtcgcag
    17401 ccggtcatcg atgagctgat ccaccgcacg cgcgggcccg acagcgcgca cccctccggc
    17461 taagccgcca cgcacagcga cgccgagttc gactaaccgg tctgccagga cttcctcgcc
    17521 cgacacgagg catgtcgcac tcacgcaacc gttcccactg cgcaaaagcc gccggtagag
    17581 ggcttcctcc gctgccgata caccaaggat tcccagacaa gcccccgcag tgtcctcctg
    17641 gtctggatgg atcgtttcac tcaccctttc tcctttgtgt tccatagggt gtgcgtggtg
    17701 acggtattgg ccagctccag ctgccgggcc tgtagtcgtc gtacttctgt ttgggcttcc
    17761 tcgggcccca tccttcggtc tcggggcgct gccgcgggcg cctggcgact tggtggagtt
    17821 ctccctgtgc ggcgagcggg tccgtaggga agtaattggc tctggccatg accagaatga
    17881 taagcctgtt cggtttcttc gccgttcgcg cggtgtgttt tgggtcaggg tggtgaggtt
    17941 cgtccggcgg gagagaagac gaaggcgccg tgacagccgt cgcaacgcga ccggagcgca
    18001 gccgccggag caggcctgga ggagtgagtg tgcggggacc gcccccgcga ccgtgggccc
    18061 tgcatggttg acccgaaatc gccggaaccc tcaccggagc gacttcagcg gctcgctgac
    18121 gagatacggc tgccactggc ggtgcacccc cggagtgccc cgcagattcg gcatcgctcg
    18181 cggcagtatc cctgtgccgt tcagaaatgc gtcgctgcag gtcgtaggcg gtctggcggg
    18241 atcggcaggc gcgctggggc catgtccagg tgatcgtgtc actggtgtgt caggtcatgc
    18301 ggaagcttct ctcggtccca gtggtgttgc tgcgtcggca gacgtccaga gacgctgagt
    18361 tgctcgtgct ccggcacgag aatgcggtgc tgcgcaggca acttgcgagt ccggtgcggt
    18421 atcagtgggc ggaccggttg tggttcgcgg cattgtcctc gctgataccc cggcgtcgct
    18481 gggctcaggt gttccctgtg acaccaggga cgttgctggg ttggcatcga cgtctcgttg
    18541 cacgcaggtg ggacgacagc gagtgtcgga gcaggccggg tcggccagcg acggcggaat
    18601 ccgtgaagga gttggtgctg cggctgacac gggagaaccc gcgctggggt gccgcaggat
    18661 caagggggag ctcgtcttcg ccgggtctac gcgctggttt tcctcgagca cggcacacgc
    18721 cgcctccaca tcgccggggt gaccacgcat ccggccgcac agtggacggc ccagcagtgc
    18781 ccttgccgga aacttcatcc gtgcaggtca cgccgcattc cggtactcgt gaaggatgcc
    18841 gccgaggcga tcgtgtcggc gtatgtcgag gcgcgctaac gtgtccgggt catcgatcgg
    18901 cgggggcaag gggcgcagtg gcctggcgtt cgcgatgccc tggtgtggtc ggtgtctgtt
    18961 gtagaactgc tcgaactcgc gcagggtgtg gaggaggtgc cgctggttcc agatcaacgt
    19021 ccggtccaag agctcgcggc gacaggtctg tatcctgaag ggtgtcttta ttgtcgtacg
    19081 gtggttgaca tggggctttg cgatcgcctg cgtgtgggca tgatcaatga ttgtgggtct
    19141 gcgactgctc tacctgatct tctgtcgact actgggctgc ttactcttgc tgggccgatc
    19201 gaccgccgcg aaccatgctg agatcctcgt gcttcgtcat gaggtcgctg tacttcgcca
    19261 gcaggtcgag cggccgcggt tttcgtgggc tgatagtgcc gtgctctccg cccttgcacg
    19321 gcaccttccc tccgtcttac gtcgccatcg gctggtcacc ccgggcacgc tgctgacctg
    19381 gcaccgacgt ctggtgcgct ggaagtggcg ccagacggcg gtcggacccg gtcggccacc
    19441 gttgccagaa gagacggtcg cgctcatcca gcgcttggcg cgagagaacc cgacctgggg
    19501 ctatgtcaga attcaaggtg agctgcggcg gcttggccat cgggtcgccg ccgccacgat
    19561 ccggcgcgtc ctgcaccgcc tcggtctacc gcccgcaccg cagcgcgcct ccagcagacc
    19621 tggcgttcct tcctgcgctc acaggcccac acgctactcg cctgcgactt catgcacgtg
    19681 gagaccgtct tcctcaagcg cctctatgtc ttcttcgtca tggagatcgc cacccggcgc
    19741 gtccatgtcc tgggcgtcac cgcccacccg accggcacat gggccaccca actcgcccgc
    19801 aacctgctca tggacctcga ggacagagcc gggcgcttcc ggttcctcat tcgtgaccgg
    19861 gacagcaagt tcaccgccgc attcgacgcc gtcttcgccg gcaacggcac agccgtcatc
    19921 ccgactccgc cacaaagccc acggtccaac gcgttcgccg aacgatggat acgcacagcc
    19981 cgcaccgagt gcaccgaccg actcctgatc accggcgaac ggcacctgcg caccgtcctc
    20041 actcagtacg ccgagcacta caacgcggga cgggcccacc gcagcctcgg cctacgggca
    20101 ccagacgacg acccgaacgt tatccccctg cccgctgcca cggtcaggcg tcgccaggta
    20161 cttggcggac tgctcaacga gtaccgcacc atgtcacccc gagtgcctca tcatccacag
    20221 gaaacgccca gctcagcagc ctgacactgc gggtgccgat aaatcatcca cgcaggtcgg
    20281 gagcctgatc acggatcttc ggttctcctc gacattcgcc caagtgcctt cacccgcaag
    20341 ggccggggcg gcatcatgat ctgtcgtgct gctgcgcctg gcctacctcg ccgcgaccaa
    20401 cgccctggcg ttcctacgcc tcctgccgat gagcgacaga gaaaaggacg tcgagatcct
    20461 ggtgctccgg caccaactgc tggtcctgca gcgtcaggtc ggcaagccga gcttcaccga
    20521 cagcgaccgt gccgtcctcg ccggcctgct ccaccacctc cccaaagaca gactgcggca
    20581 ccttctgctg ctggtccgcc ccgagaccgt cttgcactgg catcgcgaac tgctcaggcg
    20641 gcgccatgcc gcaacctgcg tacccaggcg acgcggacgc ccgcgcaccc tacggtcaat
    20701 ccgcgccctg gtcctgcgca tggccaggga gaatgcctcg tggggctatc gccggatcca
    20761 cggcgaactc gccgcactgg ggatcaaggt cgccgcctcc accgtctggg agatcccccg
    20821 cgaacacggc atcccacccg cacccgaacg acagagcacc acctgggccg acttcctccg
    20881 cagccaggcc aaggcccttc tcgcctgcga tctgttcgaa gtccgcacgc tgacgggggc
    20941 gcgcctgtac gtcttcgccg tcatcgagca caccacccgt cgcatcagaa ttctgggcgc
    21001 caacgcacat ccgaccggcg actggatcgt gcagctcgga cgcaacctcc tcatggacct
    21061 cgaagacgcg gacagcagag cacggttcct gatccacgac cgagactcga agttcacaac
    21121 cgccttcgac gccctgatgg ccgatgccgg actgaaagtc gtcaccaccg gcattcggat
    21181 accccggatg aactccctca tcgagcgctg gataaagacc tgccgcaccg aactcctgga
    21241 ccggaccctg atctggaacc agagccacct cctccgcgca ctacgcgagt acgaatcctt
    21301 ctacaacgaa caccgcccgc acagaaccct gaaaaacgcc gccccatgcc gccccacaac
    21361 ccacccccat cacccaacaa gcccagctca cccacctgga aatccacaga cgagaccggc
    21421 tcggcggaac gctccaccag caccagcacg ccgcctgagc tgcgcagatg atttatcggc
    21481 acccgcactg tcaaaccaac ccacgggtca gatgccgccc aggctgtccg gcctcccgtg
    21541 ccacccaggc cggatacatc aacgacaaga gcaccgcatt cgagcgacac gcaggcaagc
    21601 aggcaagcag gcaagcagtg ctcgtcgacc accacgccaa gcgcacacac agcggggaca
    21661 tcattctcgc tcgcttggca cactttttct tccggccagg cctccgcaaa cagtctccct
    21721 acggcgctcc agagccggat acagcgctca cgccctggga gtgccctatc tgccggcaga
    21781 cgccaagggg ctttaccgcc ccttgacgca gacccctacg gtagccaaaa gccccacgta
    21841 cagactgcct gcggaaactt gcccacaagg atcaccgacg gcctctctgc gcctgtcgca
    21901 tggggagcgc ggggccgtgc tcccacccgg aaagggggtc gggagccgac aaggggttct
    21961 tatgcctctc gatgcagaga gcatccagat cgatggggtg acctcagagg cctacggttg
    22021 acaacggcac gcaggcgctc ggtacggcgc agcaggtcta ccggatcgag tgacggacga
    22081 atcggacacc cttgacacgt ccgcgagttg ggagcacgag ggctcccaga gggctcccca
    22141 tcgctcccag cccggaaacg gttaaggccg ttcccgctac ctgcggaaac ggcctccgac
    22201 ctgcgaaaac gctggtcggg acgacaggat ttgaacctgc gaccccttga cccccaggcg
    22261 tggcaactct ctgcaacact ccgtaccacg ctgtaaccgc cagtacggcc ccgcacggag
    22321 cggtacacct ccatccgcga gggagtaccg aacagacctg acagccgtcg gcagcagccc
    22381 caacagatca tcacgacgcg aagccgacac acgatcgttc ccgccctcac gtgctcgtcc
    22441 actcaattcc tgcagagacg actgtccgtc cagcaatggg tggactccct cccactcgct
    22501 gactacctgc gcgtgatgaa
//
