LOCUS       NZ_CP058693            21086 bp    DNA     linear   CON 08-SEP-2024
DEFINITION  Streptomyces sp. Rer75 chromosome.
ACCESSION   NZ_CP058693
VERSION     NZ_CP058693.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Rer75
  ORGANISM  Streptomyces sp. Rer75
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Genome analysis of Streptomyces sp. Rer75
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-JUL-2020) College of Pharmacy, Henan University of
            Chinese Medicine, Jinshui East Road No. 156, Zhengzhou, Henan
            450046, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. Canu V1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 76.63x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013414305.1-RS_2024_09_08
            Annotation Date                   :: 09/08/2024 05:25:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,857
            CDSs (total)                      :: 8,765
            Genes (coding)                    :: 8,460
            CDSs (with protein)               :: 8,460
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 305
            CDSs (without protein)            :: 305
            Pseudo Genes (ambiguous residues) :: 0 of 305
            Pseudo Genes (frameshifted)       :: 145 of 305
            Pseudo Genes (incomplete)         :: 204 of 305
            Pseudo Genes (internal stop)      :: 20 of 305
            Pseudo Genes (multiple problems)  :: 62 of 305
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:27:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1600663
            Orig. end                         :: 1621749
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058693.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(142..157)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.26"
                     /tool="antismash"
     misc_feature    complement(347..363)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.1"
                     /tool="antismash"
     misc_feature    complement(350..362)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            488..1591
                     /locus_tag="HYQ63_RS06130"
                     /old_locus_tag="HYQ63_06130"
     CDS             488..1591
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="HYQ63_RS06130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06130"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_179932885.1"
                     /sec_met_domain="APH (E-value: 5.8e-19, bitscore: 68.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYAASSSVSAPPRPYRRQLPGNGPYLDPAPGGRARRTAVPGSVPP
                     SGRLDVSGPQGAQLRTAIAAVHRICPEFNPVQVLRRSGRSVLLVGSTGRTTAVAKCLLD
                     HSPAWAERFRREIAMYRTFVRQRPPVRVPRLIAADPDNCALVIERMPGRVAAAQRHPAE
                     APPRADVRAALGAICRINQWRPPGDLFDAPVDYAARLSRYHELGLLTDRDMGDVRKLLR
                     GVSQAAGRQLPAQFCHGDALLNNVLLAPSGAALIDWDHAGWYLPGYDLATLWAVLGDAP
                     VARRQISQLAQAAGPAARDAFLVNLMLVLTREIRRYETAVQRTMHDPAPVVPGVMAAGE
                     EQRLLLRRLHDDCGLARRAVRAAVGTR"
     misc_feature    1622..1637
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            1778..3847
                     /locus_tag="HYQ63_RS06135"
                     /old_locus_tag="HYQ63_06135"
     CDS             1778..3847
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058742.1"
                     /locus_tag="HYQ63_RS06135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06135"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_179932886.1"
                     /transl_table=11
                     /translation="MPGSAQDGAHDADAPDTNRDADRDGDRPVPGPSRRTALRTAGAAA
                     SAAFLLPVVSAAPAARADQPPSDGTSSPEGAGALQRAFVAAAQEHGVPLSVLLGVSYLQ
                     SRWDGHRGAPSVTGGYGPMHLTDAFTALSSAPHHSQGTEDARGDLARPLKVPEASVPEP
                     RQLPARLRTLDRAAELTGLSAAELRGDAAANVRGGAALLAATQKRLGLPPSEDPADWYA
                     AVAAYPGADSAAAATVFADDVYDVIRGGAARTTGDGERITLDAVPGVAPDRRQLRSLGL
                     PDPQRDPHVEAPGNVSCEWIPAPYEQFGDNDYGNHDLGNRPLSQSIDYIVIHDTEGSWD
                     TTLKLVQDPTYVSWQYTLRSSDGHIAQHVPLKDVAWHAGNWYVNAKSIGLEHEGFLTAP
                     DAWYTEAMYRSSARLVKWLARRYGIPLDRQHILGHDNVPGTTATTIRGMHTDPGPYWDW
                     AHYFSLLGAPFHRTAGASGGLVTIRPDYETNEPVYTGCERAGQECAPHGSSAVRLHTAP
                     SDDAPLVKDIGLRPDGADSTTGVNDTGARATTGQSYALAGRQGDWTAIWYLGQQSWFRN
                     PRRRPTAVYGKGLVVTPKPGLAEVPVYGRAYPEKEAYPEGVPVQAVSPLPYKLLAGQRY
                     ALGLRTQGEYLWATTFDANGHIVVRGQDVYYQIQFGHRVAFVRAADVRVRRSGR"
     gene            complement(3849..6170)
                     /locus_tag="HYQ63_RS06140"
                     /old_locus_tag="HYQ63_06140"
     CDS             complement(3849..6170)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713270.1"
                     /locus_tag="HYQ63_RS06140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06140"
                     /product="glycoside hydrolase N-terminal domain-containing
                     protein"
                     /protein_id="WP_179932887.1"
                     /transl_table=11
                     /translation="MARWTLWYDTPAADWEREALPIGNGTLGAMVFGGVARERIQFNEK
                     SLWTGGPGGPGSPPYDHGNWREPRPGALAAVQRLIDEHGAAAPEDVAARLGRPRSRYGA
                     YQTFGDLWLEIPGAPESPDGYRRRLDIRQGVALVEYTAQGARHQREFFASYPDRVIVGR
                     LGAAPGPVGFTLRHTSPRPGDHHVTARDGRLTIRGALEDNGLRFEAQVRVVCDGGTVTA
                     GEDGTLTVTGAHSAWFVLAAGTDYADTHPHYRGEDPHRAVTETVDAAASQGWLALLSRH
                     VRDHRALFDRTALDLGGRTPPGLPTDRQRAAYTGGESPADRALEELFFDYGRYLLIASS
                     RPGAPLPANLQGVWNDSIRPAWSADYHTNINLQMTYWPAHALHLAETAEPLHRFITALR
                     IPGRITAREMFGARGWVVHNETNPYGFTGVHDWPTAFWFPEAAAWLVHHLYEHYRFTLD
                     TGFLRDTAYPAMREAAAFWLDTLRPDPRDGTLVVSPGYSPEHGDFTAGPAMSQQIVHDL
                     LTATLEAARTLGDDPAFQAGLRRALDALDPGLRIGSWGQLQEWKADLDDPADTHRHASH
                     LFALHPGRQIAPNGPWAGAAAVSLDARGDGGTGWSRAWKVNFWARLRDGDRAHRLLAGQ
                     LTDSTLPNLWDTHPPFQIDGNFGAAAGIAQMLLQSHRAVLEVLPALPRRWPDGSVRGLR
                     AHGDLTVDITWREGRARSLTVTAGHDGPVRIRSDLFARPYTVHDGTTGRKTAVRDDPGD
                     ARTATLAARGGHTYRFAERT"
     misc_feature    complement(6030..6032)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6185..6685)
                     /locus_tag="HYQ63_RS06145"
                     /old_locus_tag="HYQ63_06145"
     CDS             complement(6185..6685)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="HYQ63_RS06145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06145"
                     /product="hypothetical protein"
                     /protein_id="WP_009713271.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPTGPDFDVLAMDPGDWPGDLGAGLLPAPDGTCQG
                     VFLRYDLFGGRGPAMIIGNLPEGSPAREVAEGQAPFEVTQLLAALGNEEQVQVVDTEDT
                     PVMHDDNLLIVRRIKLSEGRISCAQFDRSDGVLVTIASWDRPITDDLYRLLKPLPAEMF
                     QQG"
     misc_feature    6748..6763
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            complement(6831..9752)
                     /locus_tag="HYQ63_RS06150"
                     /old_locus_tag="HYQ63_06150"
     CDS             complement(6831..9752)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058744.1"
                     /locus_tag="HYQ63_RS06150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06150"
                     /product="AAA family ATPase"
                     /protein_id="WP_179939795.1"
                     /transl_table=11
                     /translation="MRDRQDRTRRALLEREVELAAVDHALTDLCGSDPGDPSGTRTGGV
                     IAFAGPGGLGKTALLGEMRRRAAHRGCTVMSARGGEHEQGAAFHVVRQLFQPVLATAGE
                     EEHRRILGSWYDIVAPAVGLVVSGSGGAPDPQGVRDGLDWLVTRYAVEHAPVVMILDDV
                     HWADPESLDWLLRFAARAVDLPLLLAVGYRPEDLTADAVAVRGLTERQGSRPHVLAPLT
                     PAGVGRIVRDVLGEEADEAFCRECWAVTGGNPFEVVELTAKVRDRDLKPQTVNLGALRE
                     LVAGAKDSGLGDRLTRLGTAAVRLAWAVAVLGIEATPSLAANVAGLSETETTEQVARLA
                     DARILAPPRQGARGAQPLEFLHPLIATAVYQAIPGALRVAMHGQAATVVLAAGLGSAAA
                     GRHLLEMHPEGDSWVVRHLREAAREYLRAGAPDAGRRCLARALREPPAPEERAAVLYEL
                     GCSAQLTEPSVTVNHLRAALEEPDLGADLREAITYRLAQAYGHSGRMEEAAQVVAAEVP
                     RATSARARLRMQAEQFMWSMFRADEKESPARSRRLARLADHLTGRGMAERYLLGLRAWD
                     AMTRGEPAATALHYAEEALGDGLSWTDDDWGFEVPILVALIFLHCDQPGRAEALFNTGI
                     AECERKGWRGSHLAFGITLLGYARLRRGALVEAEELAREGMRVADLVGSSTPAHWTAVG
                     TLIETLISRGRIREAQEFAAGHGGEILPQAVLCPDVPTVRGELLVASNLHGEARQQLAD
                     VGRRMDGRGMRNPVWCPWQLHMAQALALTDPHQVADDAVRRARQFGTHSAIGRALHSAA
                     AVAQGSERIKLLAEAVSHLERSPSAYDLAVALVDHGAALRRIGLPQEAGDRLYRGLEGA
                     VQCGADTLASRARDELSAAGLRPMQLRVDHTSPLTSQEQAVAERAAEGWPDDRIGEEMG
                     LAEREVARLLSGVYRKVGTDRGGLATLLGTPRPDRPAHPLPGD"
     misc_feature    9815..9832
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.89"
                     /tool="antismash"
     gene            10001..11086
                     /locus_tag="HYQ63_RS06155"
                     /old_locus_tag="HYQ63_06155"
     CDS             10001..11086
                     /EC_number="4.2.3.157"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713273.1"
                     /locus_tag="HYQ63_RS06155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06155"
                     /product="isoafricanol synthase"
                     /protein_id="WP_179932888.1"
                     /sec_met_domain="T1TS (E-value: 3.2e-74, bitscore: 249.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNATHTTTSRPPARHAALLSRAALLDIPASADPSPGTGAARVHTI
                     QWLSRYGVFRAGGAVAEYDALRFDLLAGLFYPRTTGAELDVGNDLIGWYFVFDDQFDGE
                     LGCRPEAVARMVQDVIRVTEEPDDAPGQGGGPLLESFRDLWRRIHAGRPPVWRERFRHH
                     WLEYLHSYHREALDRTGAQGPPLSVDAVLALRRHSIGVQPCLDLNERFGGYALPAALHG
                     GHPLARMREATDDVVVFTNDIASLDKELAAGDLHNTVIVRHQCHGGTLEDAVEHIAGLA
                     NARYRWFEQTADQLPRLLAEAGAGTDLRRDVDHYVDGMRDVMCGNLGWSLRTARYDERG
                     IAAVSDGRQRPWAELSAPGSG"
     gene            11146..11874
                     /locus_tag="HYQ63_RS06160"
                     /old_locus_tag="HYQ63_06160"
     CDS             11146..11874
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173683.1"
                     /locus_tag="HYQ63_RS06160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06160"
                     /product="leucine-rich repeat domain-containing protein"
                     /protein_id="WP_179932889.1"
                     /transl_table=11
                     /translation="MNDTLNLWKAGLAEAPDEIWRHTGLRVLILADNALTRLPPALGRL
                     RRLHTLDLGHNRLAEIPEEIGELSGLTRCLYLHDNRLPRLPRSLGRLGRLGYLNVGENP
                     LGSLPEELGGMAGLVELRAQHAELTGLPGSIGQLGALRELWLRGNRITALPAEVSALRG
                     LRQLELRENALSEVPEPLRGLPRLRHLDLRGNRIRTLPDWVAELPALEKLDLRWNPLDE
                     GVDDGPVVRALGERGCVVLG"
     gene            complement(11912..12157)
                     /locus_tag="HYQ63_RS06165"
                     /old_locus_tag="HYQ63_06165"
     CDS             complement(11912..12157)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987990.1"
                     /locus_tag="HYQ63_RS06165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06165"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_055556519.1"
                     /transl_table=11
                     /translation="MADTTTTAQPLRGNGEKPDLDLTGAQWQSSSQGVGDVEIAFVEGF
                     IAMRHGRRPEGPALIFTPAEWRAFVLGAREGEFDLT"
     gene            complement(12274..13449)
                     /locus_tag="HYQ63_RS06170"
                     /old_locus_tag="HYQ63_06170"
     CDS             complement(12274..13449)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467570.1"
                     /locus_tag="HYQ63_RS06170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06170"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_179932890.1"
                     /transl_table=11
                     /translation="MNTAGKEPVAVVGIGQTKHTAARRDVSIAGLVREAAVRALEDAEL
                     TWADIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAANLV
                     AARVHRTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYMRRTGAPPA
                     IGALVAYKDRRNALLNPYAHLHEQDLTLEKVQSSPMLWDPIRYSETCPSSDGACAMVLT
                     DRTGASRAPRPPAWMHGGAMRSEPTLFAGKDCVSPRAGRDCAADVYRQAGITDPRREID
                     AIEMYVPFSWYEPMWLENLGFAEEGEGWKLTESGVTEIGGDLPVNPSGGVLSTNPIGAS
                     GMLRFAEAALQVRGRAGEHQVEGARTALGHAYGGGSQFFAMWVVGAAPPTT"
     gene            complement(13446..14507)
                     /locus_tag="HYQ63_RS06175"
                     /old_locus_tag="HYQ63_06175"
     CDS             complement(13446..14507)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058749.1"
                     /locus_tag="HYQ63_RS06175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06175"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_179932891.1"
                     /transl_table=11
                     /translation="MRDVAIVAFGQSGTRRTSAEVSEVEMLMPVLHQVLGAVGLRAGEI
                     DFTCSGSSDYLAGRAFSFTMALDGVGAWPPIAESHVEMDGAWALYEAWVKLLTGEADTA
                     LVYSYGKSSPGDLPEVLTRQLDPYYVAPLWPDSVSLAALQAQALLDAGDTDERALAEVA
                     ARGRNAAADNPHAQVTRSAPPGALLDAPYLVRPLRRHDCPPIGDGAAAVVLAAGDTARR
                     LCARPAWIRGMDHRIEPHGLGVRDLTRSPSTRLAATRAGAFEAPVDLAELHAPFTSQEI
                     ILRRELELDDGVRINPSGGAPAANPMMAAGLIRLGEAAAALHRGDGDRALAHATSGPCL
                     QQNLVAVLEGEAL"
     gene            complement(14508..15467)
                     /locus_tag="HYQ63_RS06180"
                     /old_locus_tag="HYQ63_06180"
     CDS             complement(14508..15467)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058750.1"
                     /locus_tag="HYQ63_RS06180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06180"
                     /product="Zn-ribbon domain-containing OB-fold protein"
                     /protein_id="WP_179932892.1"
                     /transl_table=11
                     /translation="MTPAPAPEVLKAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRT
                     AGGRVLVPPVEYDPDTAAELRDLVEVAPTGTVTTWAWNPAPRRGQPLPTPFAWALVRLD
                     GADTSLLHALDASGPDAVRTGMRVRVRWAEEREGAITDIACFEPYDGPATHEPGPHDGA
                     FADPVTGIVAPARLDYTYAPGRAQSRYLAALAGQKTVGERCPSCRKVYVPPRGACPTCG
                     VATDEQVEVGPHGTVTTFCIVNIKARNLDIEVPYVYAHIALDGADLALHGRIGGIPYDQ
                     VRMGLRVTPVWTEGGRYPDHFRPTGEPDADYDTYKELL"
     gene            complement(15515..16321)
                     /locus_tag="HYQ63_RS06185"
                     /old_locus_tag="HYQ63_06185"
     CDS             complement(15515..16321)
                     /NRPS_PKS="Domain: ECH (15-260). E-value: 1.5e-50. Score:
                     163.8. Matches aSDomain:
                     nrpspksdomains_HYQ63_RS06185_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173688.1"
                     /locus_tag="HYQ63_RS06185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06185"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_179932893.1"
                     /transl_table=11
                     /translation="MPHGTEHLIVERIGATLVLTLNRPEAKNALSLPMLVGLYDGWIEA
                     DEDDTVRSVVLTGAGGVFCAGMDLKALAGGGRMEGQHYRDRLKTDPDLHWKAMLRHHRP
                     RKPVIAAVEGHCVAGGTEILQGTDIRVAGRGATFGLYEVRRGLFPIGGSTVRLARQVPR
                     THALEMLLTGRPYPAEEAERIGLIGHVVDDGAALKKALEIAELINANGPLAVEAVKASV
                     YETAEMTETDGLASELERGWPIFDTADAKEGSRAFAEKRPPVYRRA"
     aSDomain        complement(15542..16276)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HYQ63_RS06185_ECH.1"
                     /evalue="1.50E-50"
                     /label="HYQ63_RS06185_ECH.1"
                     /locus_tag="HYQ63_RS06185"
                     /protein_end="260"
                     /protein_start="15"
                     /score="163.8"
                     /tool="antismash"
                     /translation="TLVLTLNRPEAKNALSLPMLVGLYDGWIEADEDDTVRSVVLTGAG
                     GVFCAGMDLKALAGGGRMEGQHYRDRLKTDPDLHWKAMLRHHRPRKPVIAAVEGHCVAG
                     GTEILQGTDIRVAGRGATFGLYEVRRGLFPIGGSTVRLARQVPRTHALEMLLTGRPYPA
                     EEAERIGLIGHVVDDGAALKKALEIAELINANGPLAVEAVKASVYETAEMTETDGLASE
                     LERGWPIFDTADAKEGSRAFAEK"
     gene            16486..18111
                     /locus_tag="HYQ63_RS06190"
                     /old_locus_tag="HYQ63_06190"
     CDS             16486..18111
                     /NRPS_PKS="Domain: AMP-binding (8-438). E-value: 4.6e-70.
                     Score: 228.2. Matches aSDomain:
                     nrpspksdomains_HYQ63_RS06190_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713280.1"
                     /locus_tag="HYQ63_RS06190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06190"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_179932895.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-70, bitscore:
                     237.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESIVDTVPDREALVYADHPGTGAERRLSYAQLDAAA
                     NRLAHHLRDSGIAPGEHVGLHLFNGVEYLQTVLACLKIRAVPVNVNYRYVEDELVYLYR
                     DADLTALVYDVEFGDRVAAALPRTDTLRHLVQVGAGEGTSGAPGAVPFAEAEASGSAGR
                     GFAPRSADDRFIIYTGGTTGMPKGVVWRQEDLFFSGLGGGAPTGIPVGRPEELAERVAA
                     SGDGLVFFPTAPLMHGTSTLTTFIGLNFGQKVVLHRKFVPEEVLRTIEKEKVSTVSLVG
                     DAMLRPLVDALTGPLKGIDLSPLLSVSSSGAILSDTVRAQFAALAPHTLMLNNFGSSES
                     GFNGTATEDSGPERGFRVRVNDRTAVVDPATHRPVAPGEPGRVAQRGHVPLGYYNDPKK
                     SAETFFEADGERWVLLGDMATVDEDGVITVLGRGSQCINTGGEKVYPEEVEQALKAHPD
                     VYDALVAGVPDERWGNRVTAVVQPREGAGALTADAVRDHCRTRLAGYKIPRTVVFTDRI
                     QRSPSGKADYRWARRVAVGDGPRA"
     aSDomain        16510..17799
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HYQ63_RS06190_AMP-binding.1"
                     /evalue="4.60E-70"
                     /label="HYQ63_RS06190_AMP-binding.1"
                     /locus_tag="HYQ63_RS06190"
                     /protein_end="438"
                     /protein_start="8"
                     /score="228.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESIVDTVPDREALVYADHPGTGAERRLSYAQLDAAANRLAHHLR
                     DSGIAPGEHVGLHLFNGVEYLQTVLACLKIRAVPVNVNYRYVEDELVYLYRDADLTALV
                     YDVEFGDRVAAALPRTDTLRHLVQVGAGEGTSGAPGAVPFAEAEASGSAGRGFAPRSAD
                     DRFIIYTGGTTGMPKGVVWRQEDLFFSGLGGGAPTGIPVGRPEELAERVAASGDGLVFF
                     PTAPLMHGTSTLTTFIGLNFGQKVVLHRKFVPEEVLRTIEKEKVSTVSLVGDAMLRPLV
                     DALTGPLKGIDLSPLLSVSSSGAILSDTVRAQFAALAPHTLMLNNFGSSESGFNGTATE
                     DSGPERGFRVRVNDRTAVVDPATHRPVAPGEPGRVAQRGHVPLGYYNDPKKSAETFFEA
                     DGERWVLLGDMATVDEDGVITVLGRGSQCIN"
     CDS_motif       17005..17055
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HYQ63_RS06190_0001"
                     /evalue="6.60E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="HYQ63_RS06190"
                     /protein_end="190"
                     /protein_start="173"
                     /score="18.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVVW"
     CDS_motif       17650..17697
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HYQ63_RS06190_0002"
                     /evalue="3.60E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="HYQ63_RS06190"
                     /protein_end="404"
                     /protein_start="388"
                     /score="9.8"
                     /tool="antismash"
                     /translation="VPLGYYNDPKKSAETF"
     gene            complement(18132..18977)
                     /locus_tag="HYQ63_RS06195"
                     /old_locus_tag="HYQ63_06195"
     CDS             complement(18132..18977)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174065.1"
                     /locus_tag="HYQ63_RS06195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_06195"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_179932896.1"
                     /transl_table=11
                     /translation="MTPRIKTTKAFYRTGATTFFASQHDQRFSYSLHVPSVHETTTTPL
                     PLLVIQHGTGRTAAEYRDAMAEFSERHGCVILTPLFPAAIGDPDDLHNFKFIEYDGIRY
                     DRELLAIVDEVGTRFTVDTDRFMLQGFSGGGQFAHRFLYLHPERLRAVSIGAPGRVTLI
                     DPDREWWLGTAGFEERFGAPVRLEEIRKVPVHMVVGAEDTETWEINNPGDSNWMDGADA
                     LGRTRVERITALRDNYLALGIDVTLDIVPGVGHRGMGVLDAVRDFAARVLPRTSPPPAS
                     "
     gene            complement(19091..19609)
                     /locus_tag="HYQ63_RS44375"
     CDS             complement(19091..19609)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF033788.1"
                     /locus_tag="HYQ63_RS44375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_257231657.1"
                     /transl_table=11
                     /translation="MRFQKHRLDGARALADFPTARVEDDPPRVVFDKLYNGRASLADVP
                     CLLVPSLHINPHVAIKHYPGYPVVVQYPVRGDGDGEPPAMDEVLRRVRALDEPLRVRVC
                     RVLLRQSMTTTELASHFDTTPPQMSRHLRKLREAGMVHTHRQGARVHYQLDEEAVRTLG
                     VDLLSALRR"
     misc_feature    19599..19612
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.58"
                     /tool="antismash"
     gene            complement(<19785..20060)
                     /locus_tag="HYQ63_RS44380"
                     /pseudo=""
     CDS             complement(<19785..20060)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039924.4"
                     /locus_tag="HYQ63_RS44380"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF5937 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPVVIDLGPAPEERIAARLSPLAELCACLHALDEPRHHPASRRWV
                     GAVLQGADERLLVRAAQWAPLWGAFRARYLLPLTPGPERSLEEELAD"
     misc_feature    20926..20945
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 23.92"
                     /tool="antismash"
ORIGIN
        1 ggacggccag caccttgggc acgggatcgc gcggcgtctc gccggtgtcg atccaacgcc
       61 gcacccgcga ggtgtcggtc gccagctgcg ggtggcccat ggccgccgcg cgccggttca
      121 cgagcctcgc gagctcgccc ttggaccagc cggccaggcc gaataggtcc gcaagacggg
      181 tgttgggttc cctcgtcacg tcaagccccc aggatcctcg gctgacttga cagtaacggg
      241 cccgtcacga gccgtgcgac tattcgccag ggttcgccag ggtccgccag atggtgtgcc
      301 acccgcgcgc gggtgtgatg taggagtgcg ctacccggcc cggtggcggt tggaaaatgc
      361 cagctggaaa atgccatccg gaagatgcca gctggaaaat gccagccgca ttccccaggg
      421 tgcggtcccg ccccggggcc gggagcgtac gcacatacgt cggcacacga agggatctgt
      481 ctcgcccatg tacgcagcgt cgtcctccgt gtccgcccca cctcggccgt accggcggca
      541 gctgcccggc aatgggccgt acctcgatcc cgctcccggc ggccgcgcgc ggcgcaccgc
      601 cgtccccggc tccgtgccgc ccagcggaag actcgacgtg tccggtcccc agggtgccca
      661 gctgcgcacc gccatcgccg cggtccatcg catctgtccg gagttcaacc ccgtccaggt
      721 gctccggcgc agcgggcggt ccgtcctcct ggtcggttcg acgggccgca ccacggcggt
      781 cgccaagtgc ctgctggacc actccccggc atgggccgag cggttccgcc gcgagatagc
      841 gatgtaccgg acgttcgtac gacagcgtcc tcccgtccgg gtgccgcggc tgatcgccgc
      901 cgaccccgac aactgcgcgc tggtcatcga gcggatgccc gggcgggtcg cggccgcgca
      961 gcgccatccc gccgaggcgc cgccgcgcgc cgatgtgcgc gccgcgctcg gcgcgatctg
     1021 ccggatcaac cagtggcggc cgccggggga cctgttcgac gccccggtcg actatgccgc
     1081 ccggctgtcc cgctaccacg agttggggct gctgaccgac cgggacatgg gcgatgtgcg
     1141 caagttgctg cgcggtgtct cgcaggcggc ggggcggcag ctgccggccc agttctgcca
     1201 cggcgacgcc ctgttgaaca acgtgctgct ggccccctcg ggcgcggcgc tcatcgactg
     1261 ggaccacgcg ggctggtatc tgccgggcta cgacctggcg acgctgtggg cggtgctggg
     1321 cgacgccccg gtggcccggc gccagatcag ccagctcgcg caggcggcgg gtccggcggc
     1381 gcgggacgcg ttcctggtca acctgatgct cgtcctcacc cgggagatcc gccggtacga
     1441 gaccgccgtg cagcgcacca tgcacgatcc ggccccggtg gtgccggggg tgatggccgc
     1501 cggtgaggag cagcggctgc tgctgcggcg gctgcatgac gactgcggtc tggcccggcg
     1561 cgccgtgcgc gccgcggtgg gcacgcgctg agtcgcctca ccacaccgtc tgcggcgcgt
     1621 caccggtctg gaccggtgac gcgccgcaga cggtgtgacg tgcgaaccct ttgtcgcgtg
     1681 acggtgattg acggatcgcc tggcagcgga tacctctagg ccgtgcccct tgggaggcac
     1741 cctacggttc ggctcagccc acctcgagga ggctgcaatg ccaggatccg cacaggacgg
     1801 cgcccacgac gcagacgccc ccgacaccaa cagagacgcg gaccgggacg gcgacagacc
     1861 cgtccccggc cccagccgga ggacggcgct gcggaccgcg ggcgccgccg cgtccgccgc
     1921 ctttctgctc ccggtcgtct ccgcggcccc ggccgcccgc gccgatcagc cgccctcgga
     1981 cggcacgtca tcgccggagg gggccggggc gctgcaacgg gccttcgtgg cggcggcgca
     2041 ggagcacggg gtgccgctga gcgtgctgct gggcgtgtcg tatctccagt cccgctggga
     2101 cggccatcgt ggcgctccca gcgtcaccgg cggatacggc ccgatgcacc tcaccgacgc
     2161 cttcaccgcc ctctcctcgg ccccgcacca cagccagggc accgaggacg cccgcggcga
     2221 cctggcgcgg cccctcaagg tgccggaagc gtcggtgccc gagccgcggc agctgcccgc
     2281 gcggctgcgc acgctggacc gggccgcgga gctgacgggg ctgtccgccg ccgagctgcg
     2341 cggcgacgcg gcggccaatg tgcgcggtgg cgccgcgctg ctggccgcca cgcagaagcg
     2401 gctggggctg ccgccgagcg aggatccggc ggactggtac gcggcggtgg cggcctaccc
     2461 gggcgccgac agcgccgcgg cggccaccgt gttcgccgac gacgtctacg acgtgatccg
     2521 cggcggcgcg gcgcgcacca cgggcgacgg agagcggatc acgctcgacg ccgtccccgg
     2581 cgtcgccccg gaccggcggc agctgcggtc gctcggcctg ccggaccccc agcgggatcc
     2641 gcacgtcgag gcccccggca atgtgtcgtg cgagtggatc ccggccccct acgagcagtt
     2701 cggggacaac gactacggca accacgacct gggcaaccgc cccctctccc agtcgatcga
     2761 ctacatcgtc atccatgaca ccgagggctc ctgggacacc accctcaagc tggtccagga
     2821 cccgacgtat gtctcctggc agtacacgct gcgctcctcc gacggccata tcgcccagca
     2881 cgtaccgctc aaggacgtcg cctggcacgc gggcaactgg tacgtcaacg ccaagtccat
     2941 cggcctggag cacgagggct ttctgaccgc gcccgacgcc tggtacacgg aggcgatgta
     3001 ccggtcgtcg gcccggctgg tgaagtggct ggcacggcgg tacggcatcc cgctggaccg
     3061 gcagcacatc ctgggccacg acaatgtgcc cggcacgacc gccaccacca tcaggggcat
     3121 gcacaccgac ccgggcccgt actgggactg ggcgcactac ttcagcctcc tcggcgcgcc
     3181 gttccaccgc accgcgggcg cctccggggg gctggtcacc atccgcccgg actacgagac
     3241 gaacgagccg gtgtacaccg gctgcgagcg ggccggtcag gagtgcgccc cgcacggctc
     3301 gtccgcggtg cggctgcaca cggcgccgag cgacgacgcc ccgctggtca aggacatcgg
     3361 gctgcgtccg gacggcgccg actcgaccac cggcgtcaac gacaccggcg cccgcgccac
     3421 caccggccag agttacgcgc tcgcggggcg gcagggcgac tggacggcga tctggtacct
     3481 cggccagcag tcgtggttcc ggaacccgcg gcggcggccc acggccgtgt acggcaaggg
     3541 cctcgtcgtc acgccgaagc cgggcctggc ggaggtgccg gtgtacgggc gcgcctaccc
     3601 ggagaaggag gcgtacccgg agggcgtacc ggtgcaggcg gtctcgccgc tgccgtacaa
     3661 gctgctcgcc gggcagcggt acgcactggg gctgaggacc cagggtgagt acctgtgggc
     3721 gaccaccttc gatgcgaacg ggcacatcgt ggtgcgcggt caggacgtct actaccagat
     3781 ccagttcggg caccgggtgg cgttcgtccg ggccgcggat gtgcgggtgc ggcgctcggg
     3841 ccggtgagtc aggtccgctc cgcgaagcgg taggtgtggc cgccgcgggc cgcgagcgtg
     3901 gccgtacggg cgtccccggg atcgtcgcgt acggccgtct tgcggcccgt ggtgccgtca
     3961 tggacggtgt acgggcgcgc gaacagatcg ctgcgtatcc ggaccggtcc gtcgtgtccc
     4021 gccgtgacgg tgaggctgcg ggcgcgcccc tcgcgccagg tgatgtcgac cgtgaggtcg
     4081 ccgtgggcgc gcagcccgcg caccgagccg tccggccagc ggcgcggcag cgcgggcagg
     4141 acctccagca cggcgcggtg gctctggagc agcatctggg cgatcccggc ggcggcgccg
     4201 aagttgccgt cgatctggaa cggcggatgg gtgtcccaca ggttggggag ggtggaatcc
     4261 gtcagctgtc cggcgagcag ccgatgggcg cggtcgccgt cgcgcagccg ggcccagaag
     4321 ttgaccttcc aggcccggct ccagccggtg ccgccgtcgc cgcgcgcgtc cagggagacc
     4381 gcggcggccc cggcccaggg gccgttcggg gcgatctgcc gtccggggtg cagggcgaag
     4441 aggtgggagg cgtgccggtg ggtgtcggcg gggtcgtcca ggtcggcctt ccactcctgg
     4501 agctggcccc aggagccgat gcgcagcccc gggtcgaggg cgtccagggc gcgcctcagc
     4561 ccggcctgga aggcggggtc gtcgccgagg gtgcgggccg cctccagggt ggcggtgagc
     4621 aggtcgtgga cgatctgctg ggacatggcg ggccccgcgg tgaagtcgcc gtgctcgggc
     4681 gagtagccgg gcgagacgac gagcgtgccg tcccgggggt ccgggcgcag cgtgtccagc
     4741 cagaacgcgg cggcctcccg catcgccggg tacgcggtgt cccgcaggaa gccggtgtcg
     4801 agggtgaagc ggtagtgctc gtagaggtgg tggaccagcc aggcggccgc ctcggggaac
     4861 cagaaggcgg tgggccagtc gtggacaccg gtgaagccgt acggattggt ctcgttgtgc
     4921 acgacccagc cgcgggcgcc gaacatctcg cgggccgtga tccggccggg gatgcgcagg
     4981 gcggtgatga agcggtgcag cggctcggcg gtctccgcga ggtgcagggc gtgggccggc
     5041 cagtaggtca tctggaggtt gatgttggtg tggtagtcgg ccgaccaagc gggccggatg
     5101 ctgtcgttcc agacgccctg gagattggcg gggagcgggg cgccggggcg ggaggaggcg
     5161 atgaggagat agcggccgta gtcgaagaac agctcctcca gggcgcggtc ggccgggctc
     5221 tccccgcccg tgtacgcggc gcgttgccgg tcggtgggca ggccgggcgg ggtccggccg
     5281 ccgaggtcca gcgccgtacg gtcgaacagg gcgcggtggt cgcggacatg gcggctcagc
     5341 agggccagcc agccctggct cgcggcggcg tccacggtct cggtcacggc ccggtggggg
     5401 tcctcgccgc ggtagtgggg gtgggtgtcg gcgtagtcgg tcccggcggc gaggacgaac
     5461 caggcgctgt gggcgccggt gacggtgagc gtgccgtcct ccccggccgt cacggtgccg
     5521 ccgtcgcaca ccacccgcac ctgcgcctcg aagcgcagcc cgttgtcctc cagcgcgccg
     5581 cggatcgtca accgcccgtc gcgggcggtg acgtggtggt cgccggggcg gggtgaggtg
     5641 tggcgcaggg tgaagccgac cggtccgggg gccgcgccga gccgtccgac gatcacccga
     5701 tcggggtacg aggcgaagaa ctcgcgctgg tgccgcgcgc cttgggccgt gtactcgaca
     5761 agggccacgc cctggcggat gtcgagtcgg cggcggtaac cgtccgggga ctcgggcgcg
     5821 ccgggaatct ccagccacag atcaccgaag gtctggtagg cgccgtaacg ggagcggggc
     5881 cggccgaggc gggccgccac gtcctcgggg gcggccgcgc cgtgctcgtc gatcagccgc
     5941 tggacggcgg cgagggcccc ggggcgcggc tcacgccagt tgccgtggtc gtacggcggg
     6001 gatcccgggc cgccggggcc cccggtccat aacgacttct cgttgaactg gatccgctcc
     6061 cgggccacac cgccgaagac catggcgccg agcgtgccgt tgccgatggg gagcgcctcg
     6121 cgctcccagt ccgccgcggg ggtgtcgtac cagagcgtcc agcgtgccac cgggggtgtc
     6181 cccctcagcc ctgctggaac atctccgcgg gcagcggctt gagcagccgg tagaggtcgt
     6241 cggtgatcgg ccggtcccag ctggcgatgg tgacgaggac gccgtcgctg cggtcgaact
     6301 gggcgcagga gatccggcct tcggacagct tgatccggcg cacgatgagg aggttgtcgt
     6361 cgtgcatgac cggggtgtcc tcggtgtcca cgacctggac ctgctcctcg ttgccgaggg
     6421 cggccagcag ctgggtcacc tcgaacggag cctggccctc ggccacctcg cgggccgggg
     6481 agccctcggg cagattcccg atgatcatcg ccgggccgcg gccgccgaac aggtcgtagc
     6541 gcaggaagac gccctgacag gtgccgtccg gcgcgggcag cagccccgcg cccagatcgc
     6601 cgggccagtc ccccggatcc atggccagga catcgaagtc cggcccggtg ggcgtggcag
     6661 cgctgcggcg gcggaggaag gacatgcgga catggtacgt ggcccgccgc cgttcccctg
     6721 ctggggagcg ccctcccacg gcccgccctc acagcctctt caccagtcgg cacgcgaccc
     6781 cggacaccgg gccctcccag cccccgggag ccgcggggcc cgcccccctc tcagtccccg
     6841 gggagcgggt gcgcggggcg gtcggggcgg ggggtgccca ggagcgtggc gaggccgcct
     6901 cggtcggtgc ccaccttgcg gtagacgccg gacagcagcc gtgccacctc gcgctccgcg
     6961 aggcccatct cctcgccgat ccggtcgtcc ggccagccct cggcggcccg ctcggcgacg
     7021 gcctgctcct gcgaggtgag cgggctggtg tggtcgaccc gcagctgcat cgggcgcagc
     7081 ccggcggcgg acagctcgtc gcgggcccgg gacgccagcg tgtccgcgcc gcactggacc
     7141 gcgccctcca gcccgcggta gagccggtcc ccggcctcct ggggcaggcc gatgcggcgc
     7201 aacgcggcgc cgtggtcgac cagcgccacg gccaggtcgt acgcggacgg cgagcgctcc
     7261 agatggctga cggcctcggc caggagcttg atccgctccg atccctgggc cacggcggcg
     7321 gcgctgtgca gcgcccggcc gatcgcggag tgggtgccga actggcgggc gcggcgcacc
     7381 gcgtcgtcgg cgacctggtg ggggtcggtc agcgcgaggg cctgggccat gtggagctgc
     7441 caggggcacc agacggggtt gcgcatgccg cggccgtcca tccggcggcc gacgtcggcg
     7501 agctgctggc gggcctcgcc gtgcaggttg gaggcgacca gcagttcgcc gcggacggtg
     7561 ggcacgtcgg ggcagagcac ggcctgcggg aggatctcgc cgccgtggcc ggccgcgaac
     7621 tcctgcgcct cccggatccg gccgcggctg atcagggtct cgatgagggt gcccacggcg
     7681 gtccagtgcg cgggcgtgga ggagcccacg aggtcggcga cgcgcatgcc ctcgcgggcc
     7741 agctcctccg cctcgacgag cgctccgcgg cgcagcctgg cgtatccgag gagggtgatc
     7801 ccgaacgcca ggtgggagcc gcgccagccc ttgcgctcgc attccgcgat gccggtgttg
     7861 aacagcgcct cggcgcgtcc gggctggtcg cagtggagga agatcagggc gaccaggatc
     7921 ggcacctcga agccccagtc gtcatcggtc cagctcaggc cgtcacccag ggcctcttcc
     7981 gcgtagtgca gggcggtggc tgccggttct ccgcgcgtca tcgcgtccca ggcgcgcagg
     8041 cccagcagat agcgctcggc catgccgcgg ccggtgaggt ggtcggcgag ccgggcgagg
     8101 cgccgggagc gggcggggga ctccttctcg tcggcgcgga acatgctcca catgaactgt
     8161 tcggcctgca tgcgcagccg ggcgcgggcg ctggtggcgc ggggcacctc ggccgcgacg
     8221 acctgcgcgg cctcctccat gcggccgctg tggccgtacg cctgggcgag ccggtaggtg
     8281 atcgcctcgc gcaggtcggc gccgaggtcc ggctcctcca gggcggcccg cagatggttg
     8341 acggtgacgg agggctcggt gagctgggcg gagcagccca gctcgtacag gacggcggcg
     8401 cgctcctccg gggcgggcgg ttcgcgcagg gcgcgggcga ggcagcggcg cccggcgtcg
     8461 ggtgcgccgg cccgcagata ctcccgggcg gcctccctga gatggcgcac cacccaggag
     8521 tcgccctcgg ggtgcatctc cagcagatgg cgcccggcgg ccgcggagcc caggcccgcg
     8581 gcgagcacca cggtggcggc ctggccgtgc atggccacgc ggagcgcgcc ggggatcgcc
     8641 tggtagacgg cggtggcgat gagcgggtgg aggaattcca gcggctgggc cccgcgggcg
     8701 ccctgccgcg gcggggcgag gatgcgggcg tccgcgagcc gcgccacctg ctcggtggtc
     8761 tcggtctcgc tgagcccggc gacgttggcc gccagcgacg gggtggcctc gatgccgagg
     8821 acggcgacgg cccaggcgag gcggacggcg gcggtgccga gccgggtcag ccggtcgccg
     8881 agaccgctgt ccttcgcgcc ggcgaccagc tcgcgcaggg cgccgaggtt gaccgtctgc
     8941 ggtttcaggt cgcggtcgcg gaccttggcg gtcagctcga cgacctcgaa gggattgccg
     9001 ccggtcaccg cccagcactc gcggcagaac gcctcgtcgg cctcctcgcc gaggacgtcc
     9061 cgcacgatcc tgccgacccc ggccggggtg agcggggcga gcacatgcgg gcgcgagccc
     9121 tggcgttcgg tgaggccgcg gacggcgacg gcgtcggcgg tcaggtcctc cgggcggtag
     9181 ccgacggcga gcagcagggg caggtccacg gcgcgggcgg cgaaccggag gagccagtcc
     9241 agcgattcgg ggtcggccca gtggacgtcg tccaggatca tgacgaccgg ggcgtgctcc
     9301 accgcgtacc gggtgaccag ccagtccagg ccgtcgcgca cgccctgcgg atcgggtgcg
     9361 ccgccgctcc cggagaccac caggcccacc gcgggcgcga cgatgtcgta ccagctgccc
     9421 aggattctgc ggtgctcctc ctcgccggcc gtcgcgagca cgggctggaa gagctgccgt
     9481 acgacgtgga acgcggcgcc ctgctcgtgc tcgccgccgc gcgcagacat cacggtgcag
     9541 ccgcggtggg cggcccggcg gcgcatctcg ccgagcagcg cggtcttgcc gaggccgccc
     9601 ggcccggcga aggcgatcac tccgccggtg cgggtgccgg acggatcacc gggatcggat
     9661 ccgcacagat cggtcaacgc gtggtcgacc gcagcgagtt ccacctcccg ctccagcagt
     9721 gcccgacgtg tccggtcctg ccggtccctc atgtccgcca cgttcgatcc ccttcggcac
     9781 gtaacgccga gcgtagcctg tctggcacgc tccgtagccc ggtatgcggg tatttccttc
     9841 tggcattgcc aatggcacac gccaattcaa ctcgcgctct atcgatggca cgttcaccac
     9901 gcgaggatga ccggattcat cgggtcggcc cgtcgccgcg gggggttgtg gtattgggcg
     9961 gcgcggcctg ccccggaacc cgaagggggg cgataccgcc atgaacgcga cgcacacgac
    10021 tacttcgcgc ccgcccgccc ggcatgcggc actgctgagc cgggcggccc tgctcgacat
    10081 tccggcctcg gccgacccca gccccggaac cggggccgcc agagtgcaca ccatccagtg
    10141 gctgtcgcgg tacggcgtgt tccgggccgg tggcgcggtc gccgagtacg acgcgctccg
    10201 attcgacctg ctggcgggtc tgttctaccc ccggacgacc ggtgcggagc tcgacgtcgg
    10261 caatgatctc atcggctggt acttcgtctt cgatgatcag ttcgacggcg aactcgggtg
    10321 ccgtccggag gcggtggcgc ggatggtgca ggacgtcata cgggtcaccg aggagccgga
    10381 cgacgcaccg gggcagggcg gcgggcccct gctggagagc ttccgcgatc tgtggcggcg
    10441 catccacgcg ggccgcccac cggtatggcg ggaacgtttc cgccaccact ggctggagta
    10501 tctgcactcc tatcaccgcg aggcgctcga ccgcaccggc gcgcaaggcc ccccgctctc
    10561 ggtggacgcc gtgctggcgc tgcgccgcca ctcgatcggc gtgcagccgt gcctggacct
    10621 gaacgagcgc ttcggcggct acgccctgcc cgccgcgctg cacggcggcc atccgctggc
    10681 ccggatgcgg gaggccacgg acgacgtcgt cgtcttcacc aacgacatcg cctccctgga
    10741 caaggagctg gccgccgggg acctccacaa caccgtcatc gtccgccacc agtgccacgg
    10801 cggcaccctg gaggacgcgg tcgaacacat cgcgggcctc gccaacgcgc gctaccgctg
    10861 gttcgagcag accgcggacc agctcccccg gctgctcgcc gaggcgggtg cggggacgga
    10921 tctgcgccgg gacgtggacc actacgtgga cgggatgcgt gacgtgatgt gcggcaacct
    10981 gggctggtcc ctgcggacgg cccgctacga cgagcggggc atagcggcgg tcagcgacgg
    11041 ccgccaacga ccgtgggccg aactcagcgc ccccggttcc ggctgaccgg atccgctacg
    11101 tacgaacggc ccgccacggc gggccgttcg ggtatcaagg gcaacgtgaa cgacaccctc
    11161 aacctgtgga aggcggggct cgccgaggca ccggacgaga tctggcggca caccggtctg
    11221 cgcgtcctga tcctggccga caacgcgctc acccgcctcc cgcccgccct cggacggctg
    11281 cggcggctgc acaccctgga cctcggccac aaccggctcg ccgagatccc ggaggagatc
    11341 ggcgagctgt cgggcctgac ccgctgcctc tatctgcacg acaaccggct cccccggctg
    11401 ccgcgttccc tcggccggct cggccggctc ggctatctca acgtcggcga gaacccgctc
    11461 ggcagtctgc cggaggaact cggcggcatg gcggggctgg tggagctgcg cgcgcagcac
    11521 gccgaactga ccgggctgcc cggctcgatc gggcagctcg gcgcgctgcg ggagctgtgg
    11581 ctgcgcggca accggatcac cgccctgccc gccgaggtgt ccgcgctccg cgggctgcgt
    11641 cagctggagc tgcgggagaa cgcgctgagc gaggtccccg agccgctgcg cgggctcccg
    11701 cgcctgcgcc acctcgatct gcgcggcaac cggatcagga cgctccccga ctgggtcgcg
    11761 gagctgcccg ccctggaaaa gctcgacctg cgctggaacc cgctcgacga gggcgtcgac
    11821 gacggcccgg tcgtccgggc gctcggcgag cggggctgcg tcgtgctcgg atgaagccgg
    11881 gaccgcgtca caccgaagcc cggatgaggc gtcaggtcag gtcgaactcg ccctcgcgcg
    11941 cgcccaggac gaaggcgcgc cactcggccg gggtgaagat cagggccggg ccttcgggac
    12001 ggcggccgtg gcgcatcgcg atgaagccct cgacgaaggc gatctcgaca tcgcccaccc
    12061 cctggctgct cgactgccac tgggcgcccg tgaggtcgag gtcgggcttc tcgccgttgc
    12121 ccctgagcgg ctgtgcggtc gtggtggtgt ctgccacgtg tcggctcctc ccggatcgtc
    12181 gtcccggccc caccctagcg agcgcggccg gtgccggaca ggccacgaaa ggaggacgtg
    12241 atctgtccgg cgggtgtcgt ccgggtgcac gcctcatgtg gtgggagggg ccgccccgac
    12301 cacccacatg gcgaagaact gcgaaccgcc gccgtaggcg tggccgagcg ccgtgcgcgc
    12361 cccctcgacc tggtgctcgc ccgcccggcc gcggacctgg agggcggctt cggcgaagcg
    12421 gagcatgccg gaagcgccga tggggttggt ggacagcacc ccgcccgagg ggttgacggg
    12481 gaggtcgccg ccgatctcgg tcaccccgga ctcggtgagc ttccagccct cgccctcctc
    12541 cgcgaagccc aggttctcca gccacatcgg ctcgtaccag ctgaacggca cgtacatctc
    12601 gatcgcgtcg atctcccggc gcgggtcggt gatcccggcc tgccggtaga cgtcggcggc
    12661 gcagtcgcgc ccggcgcgcg gcgagacgca gtccttgccc gcgaagagcg tgggctcgct
    12721 gcgcatcgcg ccgccgtgca tccaggcggg cggccggggg gcgcgggagg caccggtgcg
    12781 gtcggtgagc accatggcgc acgcgccgtc ggaggagggg caggtctcgg agtagcggat
    12841 ggggtcccac agcatcggtg aggactgcac cttctccagc gtcagatcct gttcgtggag
    12901 gtgggcgtag gggttgagca gggcgttgcg gcggtccttg taggcgacga gcgcgccgat
    12961 ggccgggggc gcgccggtgc gccgcatgta cgcgcggacg tggggggcga agaatccgcc
    13021 cgccccggcc agcagcggct gctggaaggg gacgggcagc gacagccccc acatggcgtt
    13081 ggactcggac tgcttctcga acgccagggt gagcacggtg cggtggaccc gggcggcgac
    13141 caggttcgcc gcgacgagcg cggtggagcc gccgaccgat cccgcggtgt gcacacgcag
    13201 catgggtttg ccgaccgcgc cgagcgcgtc ggcgaggtac agctcgggca tcatgacgcc
    13261 ctcgaagaag tcgggcgcct tgccgatgac cacggcgtcg atgtccgccc aggtcagctc
    13321 ggcgtcctcc agggcccgta cggcggcctc ccggaccagc ccggcaatgg agacgtcgcg
    13381 ccgggcggcg gtgtgcttgg tctggccgat tcctacgacg gccaccggct ctttgcccgc
    13441 cgtgttcata gggcttcccc ttccaggacg gcgaccaggt tctgctggag acaggggccg
    13501 gaggtggcat gggccagcgc ccggtcgccg tcgccgcggt ggagggcggc ggcggcctcg
    13561 ccgagccgga tcagcccggc ggccatcatg gggttcgcgg ccggtgcccc gccggacggg
    13621 ttgatgcgta cgccgtcgtc cagctccagt tcgcggcgca ggatgatctc ctgcgaggtg
    13681 aacggggcgt ggagttcggc gaggtcgacg ggtgcctcga aggcccctgc gcgtgtcgcg
    13741 gcgagccggg tcgacgggga gcgggtgagg tcccgtacgc ccaggccgtg cggctcgatg
    13801 cggtggtcca tgccgcggat ccacgcgggg cgggcgcaca gccgccgcgc ggtgtccccg
    13861 gcggcgagca ccacggcggc cgctccgtcg ccgatgggcg ggcagtcgtg gcggcgcagc
    13921 gggcgcacca ggtacggggc gtcgaggagg gcgccgggcg gggcggagcg ggtcacctgg
    13981 gcgtggggat tgtcggcggc ggcgttgcgg ccgcgcgcgg cgacctcggc gagggcgcgc
    14041 tcgtcggtgt cgcccgcgtc gaggagcgcc tgggcctgga gggcggccag ggagaccgag
    14101 tcgggccaca ggggggcgac gtagtacggg tcgagctggc gggtgaggac ctcgggcaga
    14161 tcgccgggcg aggacttgcc gtaggagtag acgagcgcgg tgtccgcctc gccggtcagc
    14221 agcttgaccc aggcctcgta gagcgcccag gcgccgtcca tctcgacgtg ggactcggcg
    14281 atgggcggcc aggcgccgac gccgtccagc gccatggtga aggagaaggc gcggcccgcg
    14341 aggtagtcgg aggaaccgga gcaggtgaag tcgatctcgc ccgcgcgcag gcccaccgcg
    14401 ccgagcacct ggtggaggac gggcatcagc atctcgacct cggagacctc cgcgctggtg
    14461 cgccgggtcc cgctctgccc gaaggcgacg atggcgacgt ctcgcatcta caacagctcc
    14521 ttgtaggtgt cgtagtcggc gtcgggttcg ccggtgggcc ggaagtggtc ggggtagcgg
    14581 ccgccctcgg tccacacggg cgtcacccgc agccccatgc gcacctggtc gtacgggatg
    14641 ccgccgatgc ggccgtggag ggcgagatcg gcaccgtcga gggcgatgtg cgcgtagacg
    14701 tacggcactt cgatgtccag gttgcgggcc ttgatgttca cgatgcagaa agtggtgacg
    14761 gtgccgtgcg ggcccacctc gacctgttcg tcggtggcga cgccgcaggt ggggcacgcg
    14821 ccgcggggcg gtacgtacac cttgcggcag gacgggcagc gctcgccgac ggtcttctgc
    14881 ccggcgaggg cggcgaggta gcgggactgg gcgcggccgg gcgcgtaggt gtagtcgagg
    14941 cgggcggggg cgacgatgcc ggtgaccggg tcggcgaacg cgccgtcgtg gggccccggt
    15001 tcatgggtgg ccgggccgtc gtacggttcg aagcaggcga tgtcggtgat ggcgccctcg
    15061 cgctcctcgg cccagcggac ccgtacccgc atgccggtgc gcacggcgtc cggcccgctc
    15121 gcgtcgaggg cgtgcaggag ggaggtgtcg gcgccgtcga gccgtaccag cgcccaggcg
    15181 aagggggtgg gcaggggctg gccgcggcgc ggggccgggt tccaggccca ggtggtgacg
    15241 gtgccggtgg gggcgacctc gaccaggtcg cgcagttcgg cggcggtgtc cggatcgtat
    15301 tcgacgggcg ggacgagcac ccggccgccg gcggtccgta cgccgagcac ggtgcgctcg
    15361 cgcaggcccg tgaggaaggc gctctggacg gggccgaggg agcgggtgaa ggggaactcg
    15421 accacgagag gggccttcag cacctcgggg gcgggagccg gtgtcatggg gcgtctcctt
    15481 ctgcggccgg cgcggtgggg gcggcggtcc ggggtcaggc ccggcggtag accggcgggc
    15541 gtttctcggc gaaggccctc gatccctctt tggcgtcggc ggtgtcgaag atgggccagc
    15601 cgcgttcgag ttcggacgcg agaccatcgg tttcggtcat ctcggcggtc tcgtagacgg
    15661 atgccttgac cgcctcgacg gcgagcgggc cgttggcgtt gatgagttcg gcgatctcca
    15721 gggccttctt cagcgcggcg ccgtcgtcca ccacatggcc gatcagcccg atccgctcgg
    15781 cctcctcggc ggggtagggg cggccggtga gcagcatctc cagggcgtgg gtgcgcggca
    15841 cctggcgggc cagccggacc gtggagccgc cgatggggaa gagcccgcgc cggacctcgt
    15901 acagcccgaa ggtggcgccg cggccagcca cccggatgtc ggtgccctgg aggatctcgg
    15961 tgccgcccgc gacgcagtgg ccctcgacgg cggcgatcac cggtttgcgg ggccggtggt
    16021 ggcggagcat ggccttccag tggaggtcgg ggtcggtctt cagccggtcc cggtagtgct
    16081 gtccctccat ccggccgccg cccgcgagcg ccttgaggtc cattccggcg cagaagacgc
    16141 cgccggcgcc ggtgagcacg acggaccgga cggtgtcgtc ctcgtcggcc tcgatccagc
    16201 cgtcgtacag cccgaccagc atgggcaacg agagagcgtt cttggcctca ggccggttga
    16261 gcgtcagcac cagcgtggcg cctatgcgct cgacgatgag gtgttcggtc ccgtgcggca
    16321 cggcagtcct cccgtctcag acctagaaca ggttgcagga gcgacggagc gacttcaata
    16381 ggaatctgat ggccagtcag attttttggc cgcagccctt cccacctctc ccccgcggtg
    16441 ctgtcatgag cgccgagccc gcccgatgtc aggtcaggag gagccgtgga gtacaacctt
    16501 gccgacctgt tcgagtcgat cgtggacacg gtgcccgaca gagaagcgct ggtgtacgcc
    16561 gaccacccgg gcaccggcgc cgagcggcgg ctgagttacg cccagctcga cgccgccgcg
    16621 aaccggctcg cccaccacct ccgggacagc gggatcgcac cgggcgagca tgtggggctg
    16681 cacctcttca acggtgtcga gtacctccag accgtcctcg cctgcctgaa gatccgggcc
    16741 gtcccggtga acgtcaacta ccgctatgtg gaagacgagt tggtctatct ctaccgcgac
    16801 gccgatctga ccgccctggt ctacgacgtc gagttcggcg accgggtggc cgcggcactg
    16861 ccgcgtacgg acaccctgcg ccacctcgtc caggtcggcg ccggggaggg tacgtccggc
    16921 gcgcccggcg ccgtcccgtt cgccgaggcc gaggcgtcgg gctcggccgg gcgcggcttc
    16981 gcgccccgct ccgcggacga ccgcttcatc atctacaccg gcggcaccac cggcatgccc
    17041 aagggcgtgg tgtggcgtca ggaggacctc ttcttctccg ggctcggcgg cggcgcgccg
    17101 accggcatcc cggtcggccg ccccgaggag ctggccgagc gggtggcggc ctccggcgac
    17161 ggcctggtct tcttccccac cgcgccgctg atgcacggca cctcgaccct cacgaccttc
    17221 atcggcctca acttcggcca gaaggtggtc ctccaccgga agttcgtgcc cgaggaggtg
    17281 ctgaggacga tcgaaaagga aaaggtcagt acggtgtccc tggtcggtga cgcgatgctg
    17341 cggcccctgg tggacgccct caccgggccg ctgaagggca tcgacctctc cccgctgctc
    17401 agcgtcagca gctccggggc gatcctctcg gacaccgtgc gcgcccagtt cgccgcgctc
    17461 gcgccgcaca ccctgatgct caacaacttc ggctcctcgg agtccgggtt caacggcacc
    17521 gccaccgagg actccggccc cgagcgcggc ttccgggtgc gcgtcaacga ccgtacggcc
    17581 gtggtcgacc cggcgaccca ccggcccgtc gcgcccggcg aaccgggccg ggtcgcgcag
    17641 cgcggccatg tgccgctcgg ctactacaac gatccgaaga aatcggcgga gaccttcttc
    17701 gaggcggacg gcgaacgctg ggtgctcctc ggcgacatgg cgacggtcga cgaggacggc
    17761 gtgatcacgg tcctcggccg gggctcccag tgcatcaaca ccggcggcga gaaggtgtac
    17821 ccggaggagg tcgagcaggc cctgaaggcc catccggacg tgtacgacgc gctggtggcg
    17881 ggcgtccccg acgagcgctg gggcaatcgc gtgacggccg tcgtccagcc gcgagagggg
    17941 gccggtgccc tcacggccga cgcggtgcgg gaccactgcc gcacccggct cgccgggtac
    18001 aagatccccc gtacggtcgt cttcaccgac cgcatccagc gctcccccag cggcaaggcc
    18061 gactaccgct gggcccgcag ggtcgcagtc ggagacggcc cccgggcgta gcggaccgtc
    18121 ggtgggtgcc gtcaggacgc gggcggcggc gaggtacggg ggagcacccg ggcggcgaag
    18181 tcgcggaccg cgtccaggac gcccatgccg cggtgtccga cccccggcac gatgtcgagg
    18241 gtgacgtcga tccccagcgc gaggtagttg tcgcgcagtg cggtgatccg ctcgacccgg
    18301 gtccggccca gggcgtcggc gccgtccatc cagttggagt cgcccgggtt gttgatctcc
    18361 caggtctcgg tgtcctcagc gccgaccacc atgtggaccg gcaccttgcg gatctcctcc
    18421 agccgcaccg gcgcgccgaa gcgctcctcg aaaccggccg tgccgagcca ccactcgcgg
    18481 tccgggtcga tcagcgtgac ccggcccggc gcgccgatcg acacggcgcg cagccgctcc
    18541 gggtggaggt agaggaagcg gtgcgcgaac tgcccgccgc ccgagaagcc ctggagcatg
    18601 aaccggtcgg tgtcgacggt gaagcgcgtc ccgacctcgt cgacgatcgc cagcagctcc
    18661 cggtcgtagc ggatgccgtc gtactcgatg aacttgaagt tgtgcaggtc gtccgggtca
    18721 ccgatggccg cggggaacag cggggtgagg atgacgcagc cgtgccgctc ggagaactcc
    18781 gccatcgcgt cccggtactc ggccgcggtg cggccggtgc cgtgctggat caccagcagc
    18841 gggagcggtg tggtggtggt ctcgtgcacg gagggcacgt gcaggctgta ggagaaccgc
    18901 tgatcgtgct gtgaggcgaa gaaggtggtg gcgccggtgc ggtagaacgc cttggtggtc
    18961 ttgatgcgcg gtgtcacatg tcctcctgcg atgcgccgcc accgacgtgg ggcggtgccc
    19021 gtcacgatca cgggtgcgtc ggcggcggct caagatgatt gccgcgcagg cgtcaatgac
    19081 accgaccgtg tcagcggcgc agtgcggaga gcaggtcgac gccgagggtg cggacggctt
    19141 cctcgtccag ctggtagtgc acccgggcgc cctgccggtg ggtgtgcacc attccggcct
    19201 cccggagttt gcgcagatgg cgcgacatct gcggcggggt ggtgtcgaag tggctggcca
    19261 gctcggtcgt cgtcatcgac tgccgcagca ggacgcggca caccctgacg cgcaggggct
    19321 cgtccagcgc ccgtacccgg cgcagcacct cgtccatggc gggtggctcc ccgtcgccgt
    19381 ctccccgcac cgggtactgc acgaccacgg gatatccggg gtagtgcttg atcgccacgt
    19441 gcgggttgat gtgcagcgag ggcaccagca ggcacgggac gtcggcgagg ctggcccgcc
    19501 cgttgtacag cttgtcgaag acgacccgcg gcggatcgtc ctcgacccgt gcggtgggga
    19561 agtcggcgag cgcccgggcg ccgtccagcc ggtgtttctg gaagcgcatg cggacgtcgc
    19621 ctcagcgcga accgggcctc cgaacagctc gtcggcggcg cgtgcagcct gccgaggaag
    19681 cggtcggggg agttccccgc ggcgcccgtg ggccggtggc tgttctgccc gatcagggcc
    19741 tgttccgtca tggccgtgaa cgtcgcctcg ggcagctcgc cgatgtcggc cagctcctcc
    19801 tccagggagc gctccggccc gggggtgagg ggcagcagat agcgggcgcg gaacgcgccc
    19861 cacagcggtg cccactgcgc ggcccgcacc agcagccgtt cgtccgcgcc ctggagcacg
    19921 gcgccgaccc agcggcggct ggccggatgg tgccggggct cgtccagcgc gtgcaggcag
    19981 gcgcacagct cggcgagcgg ggacagccgt gcggcgatgc gctcctcggg agcggggccc
    20041 aggtcgatca ctacgggcat gcgtcgacgg tccgggattg acgccttgct gtcaatcgtc
    20101 ttgtggccgg atcgcgaggg gcgcaggctc cggtcatctt cccggccgcc ccctcagccc
    20161 ccgatcccgt ccccgatttc cgcacctctc cgcgacggag cgtttccatg ccccctctcc
    20221 tccggaacgg tccacgcgtc gtgctgaccg tcaccttgct ggccacggtg agcagcgcgt
    20281 gcaccatcgg ttccgccgac gactccaccg cggccgccgg ctacccctcc cgcggcctgt
    20341 ccatcctggc ccccggcagc gtcggcggcg gctgggacgc ccgggcccgc ggcatgagcg
    20401 ccgcgctcac cggctgcggg gtcatcgacg aggacgtcac ggtcaccaac aagccgggcg
    20461 cgggcggagc catcgggctc gcccggatgg tcggccgcag cggcgacccg taccagctga
    20521 tgaccatgga cacggtcacc atggccgggg gcgcggtgca gaacgactcc ccggtcgggc
    20581 tctcgtccct caccccgatc gccgggctga ccgtgagccc cagcgtgatc gtggtgcccg
    20641 cccgctcccc gttccgcgat ctgacgtcgg tgatggcggc catgaggcgg aaccccaagg
    20701 gcatgtcctg ggtgggcggt tcgctgggcg gccccgacca catcaccgtc gcctccctcg
    20761 ccaaggcgag gggaatcccc gtcagcaaga tcacctacgt gccgaccggc ggtggcggcg
    20821 aagtgctcaa cctgctgctg agcggggcgt ccaaggtcgg catgtcgaca ctgaccgaga
    20881 tccgtccgca gatcgaggcg ggcaagctca gggtcctcgc gatcagcggc gacgaacgtc
    20941 ccgaggggct ggacgccccg accctgaggg acctcggata cggcggggcg agcgtggtga
    21001 gcaccggcgg tgtgatggcc ccgcccggcc tgagcgacgg tgaacggcgg gcgatcgtgg
    21061 cgatggtcga ccggatgcgc cgcacc
//
