LOCUS       NZ_CP058693            22095 bp    DNA     linear   CON 08-SEP-2024
DEFINITION  Streptomyces sp. Rer75 chromosome.
ACCESSION   NZ_CP058693
VERSION     NZ_CP058693.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Rer75
  ORGANISM  Streptomyces sp. Rer75
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Genome analysis of Streptomyces sp. Rer75
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-JUL-2020) College of Pharmacy, Henan University of
            Chinese Medicine, Jinshui East Road No. 156, Zhengzhou, Henan
            450046, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. Canu V1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 76.63x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013414305.1-RS_2024_09_08
            Annotation Date                   :: 09/08/2024 05:25:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,857
            CDSs (total)                      :: 8,765
            Genes (coding)                    :: 8,460
            CDSs (with protein)               :: 8,460
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 305
            CDSs (without protein)            :: 305
            Pseudo Genes (ambiguous residues) :: 0 of 305
            Pseudo Genes (frameshifted)       :: 145 of 305
            Pseudo Genes (incomplete)         :: 204 of 305
            Pseudo Genes (internal stop)      :: 20 of 305
            Pseudo Genes (multiple problems)  :: 62 of 305
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:27:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1000174
            Orig. end                         :: 1022269
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058693.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22095
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="6"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22095
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22095
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12095](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12095)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(771..786)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            complement(1112..2047)
                     /locus_tag="HYQ63_RS03530"
                     /old_locus_tag="HYQ63_03530"
     CDS             complement(1112..2047)
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712674.1"
                     /locus_tag="HYQ63_RS03530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03530"
                     /product="TAXI family TRAP transporter solute-binding
                     subunit"
                     /protein_id="WP_179932461.1"
                     /transl_table=11
                     /translation="MHTVPRRLLLALAAGGLAGCSDPGPSARVRLATGPRGGPYATFGS
                     RLATEAHRAHHGLTVRVLTTAASVENLRMLGDGRADLALTLADSAADAAAGSGLFRRKM
                     PVAALARLYLNYLHLVVPADSTIEHPAQLAGRTVSLGAAESGTSTTAGRVLSAAGVRDV
                     RAVRLGLGASADALTDGEVDAFFWSGGAPTWAISQLARRCPLRLIPLGGLARALRRDHG
                     PVYEEVSVPAGAYGMRGPTLTVGTPSYLVCRSGLADGTARALTDVLFERRDRLAVPDAP
                     GSRLDERYAIGTGTVPLHPGAAAYYRAAYG"
     gene            complement(2080..2481)
                     /locus_tag="HYQ63_RS03535"
                     /old_locus_tag="HYQ63_03535"
     CDS             complement(2080..2481)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712675.1"
                     /locus_tag="HYQ63_RS03535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03535"
                     /product="ATP-binding protein"
                     /protein_id="WP_257231581.1"
                     /transl_table=11
                     /translation="MALRQESLQLPARGASVAAARRLVRNRVPHWGFDEDVCGAAELVM
                     SELFTNALVHTASDQILCVLRAQERRSLYVEVADQGGGPLGPMPREAGVEDESGRGLAL
                     VRALTEAWGDRPGAAGGRVVWAQLSALAR"
     misc_feature    complement(2683..2695)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            2773..3630
                     /locus_tag="HYQ63_RS03540"
                     /old_locus_tag="HYQ63_03540"
     CDS             2773..3630
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135308.1"
                     /locus_tag="HYQ63_RS03540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03540"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_179932463.1"
                     /transl_table=11
                     /translation="MGEARSAPTVGQMVLGMRLRHLRERAGVSYDAAAKALHVNQTTVR
                     RMEKAEVGLKLPYVEKLLRTYGVEQDEVESFLGLVEEANRPGWWHRFRDVLPDWFSLYV
                     SLEGAASRIRAYEPHFVPGLLQTEDYARALLRIGFPQGTEEELDRRVALRMERQELLSR
                     PDGPHLWAVMDETVLRLHIGGPKIMRAQIDRLIEAVRMPNVTLQVVPFAAGPHPGMGGP
                     FQLFRFQIPELPDIVYAEGLTGAGYLDQRTEVAAHLEALDRMGTQATSARRTEGFLREI
                     RKEL"
     gene            3633..3938
                     /locus_tag="HYQ63_RS03545"
                     /old_locus_tag="HYQ63_03545"
     CDS             3633..3938
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602002.1"
                     /locus_tag="HYQ63_RS03545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03545"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_179932464.1"
                     /transl_table=11
                     /translation="MDQVEDVYNGMPATRLATEGWRKPWSGPNGGACVEALRLHDGRIA
                     LRQSTDPDGPALIYTHHEMEKFIQGAKAGAADFLLTRPDPNNLATSAANAPERRAA"
     gene            3935..4756
                     /locus_tag="HYQ63_RS03550"
                     /old_locus_tag="HYQ63_03550"
     CDS             3935..4756
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712678.1"
                     /locus_tag="HYQ63_RS03550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03550"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_179932465.1"
                     /transl_table=11
                     /translation="MTDYGLAPDQQIDTSKPHSARMYDFYLNGKDHYEVDAEAAGKVLS
                     VYPTVKLNATVNRGFIHRATRWLAAEAGIRQFLDIGTGIPTEPNLHQVAQSVAPEARVV
                     YTDYDPIVLAYAQALLRGTPEGRTAYVQADVREPQRIITATELRETFDLSKPVALSVNA
                     LFHFIPEEEKPYEIVAELMGALAPGSYLMLTHSTADFHAETWQKVIAVYKESGISFTTR
                     NRSEVAAFFDGLELVDPGVSEPHAWKPDPGDRPDEIRSADINMWAGVARKP"
     gene            complement(4814..6214)
                     /locus_tag="HYQ63_RS03555"
                     /old_locus_tag="HYQ63_03555"
     CDS             complement(4814..6214)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712679.1"
                     /locus_tag="HYQ63_RS03555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03555"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_179932466.1"
                     /transl_table=11
                     /translation="MRFPLRRHPRPSLHTTFALSFAAVASVVTLLVGFLSYDAAAGLVR
                     VDQKSAFTDVIRDLRTQVRGQKVILRQYPSEVPVPYGLRDDLRRISRMDVQVLGGRGDV
                     YDKGKPALPVGDEDRETAAAATAGTTRQRNISIGEDDYRMATVALGDHRGAVQVAQQIS
                     DTEDLLRELQKRTALFVVAIIVAAGLAGWWLAGRITRRLVRLTRVAESVAVTGRMEVAV
                     PVAGDDEVGRLGRAFDGMLGRLARSKDDQRRLVQDAGHELRTPLTSLRTNISLLSRFEQ
                     LPPAARDELLADLAGETRELTDLVNELVDLAAGQRDDEPRTEVSLDEVATKAATLARRR
                     TGRDITVRAEGDTLVEGHPAALLRAVSNLVENAAKFDRDGTGPVEVVVTGHRVEVRDRG
                     PGIAEEDRERLFDRFYRAPGARSLPGSGLGLAIVREVALAHGGTVFARSRPGGGAVLGF
                     TVDGPEEP"
     gene            complement(6218..6922)
                     /locus_tag="HYQ63_RS03560"
                     /old_locus_tag="HYQ63_03560"
     CDS             complement(6218..6922)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056913.1"
                     /locus_tag="HYQ63_RS03560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03560"
                     /product="response regulator transcription factor"
                     /protein_id="WP_179932467.1"
                     /transl_table=11
                     /translation="MTNTVLLAEDDRAIRHALERALTLEGYRVTAVSDGVEALAAIHRE
                     HPDVIVLDVMMPGVDGIQVCRVLRAEGDRTPILMLTARVETADRIEGLDAGADDYVAKP
                     FDVEEVFARLRALLRRAAPIPEPAGEGTVFDATLEVADLRLDPSARRVWRGGTELELTR
                     TEFDLLELLARNAGIVLDHGTIYSRIWGYDFGPGSKNLAVYIGYLRRKVDQVGLTPLIH
                     TVRGVGYTLREE"
     misc_feature    7095..7110
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            7096..8361
                     /locus_tag="HYQ63_RS03565"
                     /old_locus_tag="HYQ63_03565"
     CDS             7096..8361
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712681.1"
                     /locus_tag="HYQ63_RS03565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03565"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_179932468.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 6.3e-39,
                     bitscore: 132.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVFLLHNAYGIGGTIRTTLNLAAALAERHDVEIVSMMRHRGKP
                     RFTIDPRVRLVPLVDTRPGGHDARDPLFAERTRDFPVHEKRNHQYNRLMDVRIARYLEG
                     SDADVIIGTRPGVNVYLARFGPRKALRIAQEHLRYEAHSKKLRAELAPYYRMLDAVVTT
                     TEADAAVYRAKMPLPGAWTLAIPNSVPEPAAAPSEGTAPVIAAAGRLVRGKRFDLLIDA
                     FAEVSPKHPEWRLRIYGGGSQKDRLQERIEELGLTGSAELMGPYSPIEEEFAKASIVAV
                     ASDAESFGMTIVEAMRCGVPVVSTDCPLGPAEIIEDGVTGRLVPVGDKQAMAQALRDLI
                     DDEPGRRAMAAAALESARTYDPEPIAVRYERLFEELASSRFARSWERTRVRLRAGYRRK
                     VRRWKRAFRRRLPAAGGKSAKA"
     misc_feature    7097..7111
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            complement(8405..9913)
                     /locus_tag="HYQ63_RS03570"
                     /old_locus_tag="HYQ63_03570"
     CDS             complement(8405..9913)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152586.1"
                     /locus_tag="HYQ63_RS03570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03570"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_179932469.1"
                     /transl_table=11
                     /translation="MTVTDDGRAEQTGAGQPGAEHTGAEAPGIDPERLATCLSVLEELD
                     RLPIDHPDAITVRRATAGIYRTVKQRRRSERRAAKTANDKAVTEATATGAADRIDDETL
                     GRALSSSVTTEIAGILERPRSCYVCKTRYVEVDAFYHQLCRGCAAENRARRDARTDLTG
                     RRALLTGGRAKIGMYIALRLLRDGAHTTVTTRFPNDAIRRFTAMPDSAEWLHRLKIVGI
                     DLRDPAQVIALADEVSAAGPLDILINNAAQTVRRTPQAYAELIAGESAPLPAGELPEAV
                     VLGAFGSGSQTALPGPRRERDGALTPQDLTALALNRGSASPARIEAGTAIDAGGLVPDL
                     DPTNTWIQRVHEVDPVEMLEVQLCNETAPFILVSRLRPAMAAAPARRKYVVNVSAMEGK
                     FGRGYKGAGHPHTNMAKASLNMLTRTSAREMFESDAILMTSVDTGWITDERPHPDKMRL
                     AADGFHAPLDLVDGAARVYDPIVRGEQGEDLFGCFLKDYAPTTW"
     gene            complement(10001..11137)
                     /gene="pqqE"
                     /locus_tag="HYQ63_RS03575"
                     /old_locus_tag="HYQ63_03575"
     CDS             complement(10001..11137)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712683.1"
                     /locus_tag="HYQ63_RS03575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03575"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_179932470.1"
                     /sec_met_domain="PF04055 (E-value: 9.9e-23, bitscore: 80.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2e-06, bitscore: 27.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.5e-06, bitscore: 27.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.8e-09, bitscore:
                     35.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAHPQEHSQGHPQGTAHPRPWALLAELTHGCPLHCPYCSNPLQL
                     VRRSRELTGEEWERVLRQAAELGVVHTHLSGGEPLLRRDLEAIVAAAASAGLYTQLVTS
                     GVGLDEARLTALTGAGLHSVQLSVQHASPGASDRIAGHRSFAAKERAAALVREAGLPLG
                     VNVVLHRDNLDALDGLIELAVAWGADRIELANTQFYGWALRNRAALLPTREQLARAREG
                     VARWREKLGGRTELVWVLPDYFEGVAKPCMGGWGAVSLTVAPDGTVLPCPAAAALPGLD
                     PPNVRDHALEWIWDHSAAFNRYRGEEWMAEPCRSCSHRAEDFGGCRCQAYALTGDAART
                     DPACALSPDHGLIRSLTGPAPAAEPPPPGYTYRGYGRG"
     gene            complement(11134..11400)
                     /gene="pqqD"
                     /locus_tag="HYQ63_RS03580"
                     /old_locus_tag="HYQ63_03580"
     CDS             complement(11134..11400)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433952.1"
                     /locus_tag="HYQ63_RS03580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03580"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_179932471.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2.6e-19, bitscore:
                     67.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1e-11, bitscore: 44.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPAAWRPALAPAVHLRHDRVREVDLLVMPERVVVLRGTAGTVL
                     RLCDGDRDLDTIVAELAERFPGAPVATDVPAFLGRMHEEGWIR"
     aSDomain        complement(11140..11379)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HYQ63_RS03580_PqqD_RRE.1"
                     /evalue="8.40E-22"
                     /identifier="RREFam006.1"
                     /label="HYQ63_RS03580"
                     /locus_tag="HYQ63_RS03580"
                     /protein_end="87"
                     /protein_start="7"
                     /score="67.7"
                     /tool="antismash"
                     /translation="RPALAPAVHLRHDRVREVDLLVMPERVVVLRGTAGTVLRLCDGDR
                     DLDTIVAELAERFPGAPVATDVPAFLGRMHEEGWI"
     gene            complement(11397..12095)
                     /gene="pqqC"
                     /locus_tag="HYQ63_RS03585"
                     /old_locus_tag="HYQ63_03585"
     CDS             complement(11397..12095)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712685.1"
                     /locus_tag="HYQ63_RS03585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03585"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_179932472.1"
                     /sec_met_domain="TIGR02111 (E-value: 8.8e-82, bitscore:
                     273.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSLEERLRAVAQERYHDRHPFNLRMHAGELTPAELRRWILNRF
                     HYQRHIPVKDALITAKLDNPRLRRMWLRRIQDHDGAADGEGGIERWLRLGEAAGIGRER
                     LLTGADVLPGVRLAVDGYVNFCRLGTPLEAVAASLTELSAPGIMRTRIEAFEHHYPWIE
                     REGLRYFRDRVSQGSRDSAEALDLVLTWACTPEDEERAVAALTFKCDVLWSLLDAVDHA
                     DTKDTAGEGT"
     gene            complement(12092..12991)
                     /gene="pqqB"
                     /locus_tag="HYQ63_RS03590"
                     /old_locus_tag="HYQ63_03590"
     CDS             complement(12092..12991)
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="HYQ63_RS03590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03590"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_179932473.1"
                     /transl_table=11
                     /translation="MRVRVLGTAAGGGVPQWNCACPGCSGARAHPERRRRHASLAVRAA
                     EGRWYLVNATPDLGDQVEDCPELHPGPEPRHTPLAGVILTDAELDHTLGIARLREADRI
                     RIVATAPVRHALLTGLRLGDVLTPYAALDWDDLGPGDRPLAEDGDLTIAAVPVSAKRPR
                     YAAGLDGHDEGAWVVALRLTDRATGRSLLYAPALAAWPDAFQRAAEDADCVIVDGTFWD
                     DEEPLRSGFGSRTATAMGHLPIEGPGGTAPRLAALGARTLYTHLNNTNPLNDPAAPQHA
                     VLAGRGIEVAADGMVIEL"
     misc_feature    complement(12095..12097)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13003..13146)
                     /gene="pqqA"
                     /locus_tag="HYQ63_RS03595"
                     /old_locus_tag="HYQ63_03595"
     CDS             complement(13003..13146)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_093467075.1"
                     /locus_tag="HYQ63_RS03595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03595"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_009712687.1"
                     /transl_table=11
                     /translation="MNETVRQTAPEAVDHTRTPAPETAWQTPDYVVVETALEVTAYSLN
                     AR"
     gene            complement(13210..14709)
                     /locus_tag="HYQ63_RS03600"
                     /old_locus_tag="HYQ63_03600"
     CDS             complement(13210..14709)
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012516.5"
                     /locus_tag="HYQ63_RS03600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03600"
                     /product="glycoside hydrolase family 28 protein"
                     /protein_id="WP_179932474.1"
                     /transl_table=11
                     /translation="MTRWTRLRFAAATAAAACVLAAVPPDAGAAGGTARTYDVRDYGAT
                     GDGTTLDDDAIDRAIDAAAAAPGRGTVLFPPGTYKSRTLHLKSDITLHLAKGATLLAAA
                     GGMDEAEPNPWDAYQDFGHSHFRNALLTGENIHHLAITGSGTLDGEGLGTSNTLEPGVG
                     DKILSLKRCTDLDIEDVTFTRGGHFALLLNGCDGVRMTRTKVLTSTDRDAVNLINSRHV
                     DIGHSRIEGRDDGVVLKSDYALGRTYTSHDIRVHDSDVLSTENNALQFGSETCGDFRDI
                     RFDRLRIGGGGKAAIGIVSMDGADIGDVRYSDITMTKGATPVFIKIGDRKRCPGAPPAG
                     RIHDIRFSHVTGTGLTHPVTGVDYTSTITGAPGADVTDITFDRVRLAVPGGHPASDAEL
                     VPGEYLTDYVPKTYGVRPSYGWWIRHAKDITFTNSAVTTDTNDDRPAFIADDGVGITLD
                     RVTARRGTASPYDVGFSGVTGPVVRHGTTTDGEALRIRTTG"
     misc_feature    complement(14769..14781)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(14927..14942)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.54"
                     /tool="antismash"
     gene            15019..15825
                     /locus_tag="HYQ63_RS03605"
                     /old_locus_tag="HYQ63_03605"
     CDS             15019..15825
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056901.1"
                     /locus_tag="HYQ63_RS03605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03605"
                     /product="hypothetical protein"
                     /protein_id="WP_179932475.1"
                     /transl_table=11
                     /translation="MERPPLLPRTALTLAATAALIAPAAVAYGTERSPQAPAASWSLKW
                     NPASGASVASAFEGAEDDRADSHPGTTHIYPSQGGFRTDMHYPRDVDTSTDRQRNEVRG
                     MKQDGSAVKILKNETWRIQYQMYVPDTLDATTSFTHIMQIKVGDVAAPLFTMSLHQHGD
                     GPKVEIRTSDDDENLTEAGAANMSPLQGAWSDVSVEVKAADSGAYADWSVTTGGKKVAA
                     HKRTGLDLWRGKNYLRPKWGIYRSLNSGGLQTTYLLTRNFKAYKLQ"
     misc_feature    15037..15039
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15837..16928
                     /locus_tag="HYQ63_RS03610"
                     /old_locus_tag="HYQ63_03610"
     CDS             15837..16928
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712691.1"
                     /locus_tag="HYQ63_RS03610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03610"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_179932476.1"
                     /transl_table=11
                     /translation="MKSCRNTLVAAAATTALTAGLLLTQAGTGNAAPAAADSARSAPSA
                     ITTVSSGWSIPWGLSWLPDGSALITERDSFKLFKLTQSGTKTQVGTVPNVVTTSGEGGL
                     MGLAVSPNWNTDHYVYLMHTASDGNRIARMTYDGSNVSGYKAIVTGIKKNKYHNGGRLK
                     FGPDGYLYATTGDAQTTSNAQDKNSLNGKILRMTTDGKAAPGNPFGTLVYSLGHRNPQG
                     LTWDAQGRLWEAELGNSTYDELNLIEAGKNYGWPTCEGSCSTSGMTNPKRQWSVGEASP
                     SGVTYADGALYMAALRGERLWRIPVDGTSAGTPKAYYTSSYGRLRTVETVPGKNTLWLS
                     TTNADNNGGEPDGADKVFQVELK"
     gene            complement(16984..18135)
                     /locus_tag="HYQ63_RS03615"
                     /old_locus_tag="HYQ63_03615"
     CDS             complement(16984..18135)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712692.1"
                     /locus_tag="HYQ63_RS03615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03615"
                     /product="glycoside hydrolase family 105 protein"
                     /protein_id="WP_179932477.1"
                     /transl_table=11
                     /translation="MIRRRTVLASALGIGGGLLLPGTGTAHAAARTDWSRAVVDSTIAR
                     YPDPASLGGWGYTRGLFLLGAYRVYQRVGEPSYLAYIKRWVDKFVDADGHMSRTFDNLD
                     AMQSGNLLLMLHRETGDARYRTAAGQIRARFADYPRTADGGMWHATGKTNELWGDGVFM
                     AQPFLLRYGIAYGDKAYAYDEVTRNLSVYFRHLKASNGLIYHAYDADGDAPWNPDATTG
                     TSAHFWARAIGWTAMTHIEVLEMLPARHPRRAELIANVRHLARGFLRYQDRATGRWFQV
                     VDKAGEPGNWTETSASSMYTLMLHAALGHGWIRGGDYAAAARRGYRGVLDKVTVGADGL
                     TNIADISEGTNVGDLAYYLGRPRNTNDLHGLGAFLLMNERLAY"
     misc_feature    complement(18373..18393)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    18382..18400
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 31.2"
                     /tool="antismash"
     gene            18416..19402
                     /locus_tag="HYQ63_RS03620"
                     /old_locus_tag="HYQ63_03620"
     CDS             18416..19402
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056895.1"
                     /locus_tag="HYQ63_RS03620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03620"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_179932478.1"
                     /transl_table=11
                     /translation="MRNPRLFPLLTTAALAATVLTGCGPAESADSSSASAQRPGARQAD
                     GSFPRTVVHELGSTPVKAKPRRIAVVSTGQLDDLLTLGLVPAATTRADNAGLVPDYLRD
                     AFPGKAKALAAMTDIGTRSSPALEKLAAAGPDLILVNSTQGDLYPTLSAIAPTVVTKGR
                     GVNWKKDLLTVADAVGERDRARTVVSRFEKDAARQGRKLGGKDTELSMVRFNPDRVRMF
                     GAKSFTGTIADDMGLGRPASQRFDDISQDLSGERIPEMDGDWIFYSIQGRPGKTDAGAY
                     LSNPLWKKLDAVRAGHTVTVDDDPWYLNAGPTAARVVLDDITEHLGR"
     gene            19569..20993
                     /locus_tag="HYQ63_RS03625"
                     /old_locus_tag="HYQ63_03625"
     CDS             19569..20993
                     /EC_number="6.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712696.1"
                     /locus_tag="HYQ63_RS03625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_03625"
                     /product="glutamine synthetase family protein"
                     /protein_id="WP_179932479.1"
                     /transl_table=11
                     /translation="MGTGDREQAQARARQEADRLTAQGIHGIALTWVDNAGLTRVKSVP
                     TGRLAHSARRGVGMSPVFDVYLVDDSMTTSPHIGGPDGDLRLFPDLDRLTVLAAQPGWA
                     WAPADRYAQSGLEHPTCQRLFARRMAERAHGRGIALRMGFETEWIVTTGGTDAAGGTGA
                     PRSARDTPGPVPYDATPGPRYAGTGPAYGMARLVDLSGYLADVLDTLHTQGVEVLQLHP
                     EYAAGQFEVSVAPADPVGAADLAVLVRETIRGVSARHGLTPLFGPVAEAGTVGNGGHLH
                     LSLWQGERNLCRDGDGPHGMTATSEAFLAGVLRALPALLAIGAPSPASYLRLEPSRWAG
                     AYQCWGLENREAALRFITGAPDDPGGANAEVKCFDPAANPYLVTGAVIAAGLAGLDAGL
                     TLPPPVSGDPARTDRERRLPTSLPAALEHFEDSAVLREALGDPLFESIAAVRRAEAALF
                     EKAAPQEIAAATRGRY"
     misc_feature    complement(21739..21757)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.34"
                     /tool="antismash"
ORIGIN
        1 cgagcccgcc gagcgggcgc tgtccggccg taccaccgga agcctgcccc tggtcacccc
       61 gttcggcccg ggggcggtgg tgatcgccga gccggtcggc cgggacgccc aggtctccgg
      121 cgtggtgctc atgcgggtgg ccacggccac cgcccggcgc gaggtggcgt tcgtctgggc
      181 ggcggtcgcg ggcggctcgc tgatcgcggt ggcctgcgcc ctgatcgccg cgcgccgcct
      241 cgcgcggtgg atcctgcggc cggtgaccga actggacctc accacccggg cgatcgccga
      301 gggccggatg gacgcccggg tgcgcgacgg cggccacggc cccgccgagc tgcggctgct
      361 ggagcagcgg ttcaacgcca tggccgacgc ggtctccacc gccctggagc ggcagcgcgc
      421 cttcgtcgcg gacgcctcgc acgaactgcg caccccgctg accgtcctgt ccctgcggct
      481 ggagaacctg gagccgcacc tgcgggacag cgggaccgtc gactacgccg aagcgctcgc
      541 ggaggtcgac cggctggccg agctgctgga agacctgctg gagctggccc gggtggaggc
      601 cggggcggcc gaccccgagc cgatcccgcc cgcggcactc gccgcgcggc tcggcacctg
      661 gcgcgaggtg cacgcggcgc gggggctgac cctggtggtg gacgtcgacc gggcgggccc
      721 ggacgccccg ccgctgcccg ccccggccgc ccggatcgcg gacatcgcgc tggacaactc
      781 ggccaagttc gtgccgtccg gcggcacggt caccgtctcg ctcgacgccg ccggagcgct
      841 gcggatcgcc gacgacggcc ccgggctcgc ccccgaacag ctggccgcgg cccccggccg
      901 cttctggcgc gccccggacc acgggaacgt ccccggcagc ggcctgggcc tggccatcgc
      961 cgccgagctg gcccgctcct gcggcgccga gctgacgctg cgctccgccg agccgcgcgg
     1021 gctggtggtg gagctgcgcc tgccggtggg ctgacggtgc ctcccgcggc agcggcatgc
     1081 gagcgtggtg aacccgcgac gggccgggcc gtcagccgta ggcggcgcgg tagtaggcgg
     1141 ccgcgcccgg gtggaggggg acggtgccgg tgccgatggc gtaccgctcg tccaggcggc
     1201 tgcccggcgc gtccggcacc gccagcctgt cgcggcgctc gaagagcaca tcggtgagcg
     1261 cgcgggccgt accgtcggcg agcccggagc ggcagacgag atagctgggc gtgcccacgg
     1321 tgagggtcgg cccccgcatc ccgtacgcac cggccgggac ggagacctcc tcgtagaccg
     1381 ggccgtggtc gcgccgcagc gcgcgggcga gcccgccgag ggggatcagg cggagcgggc
     1441 agcggcgggc gagctgggag atggcccagg tgggggcgcc gccggaccag aagaaggcgt
     1501 ccacctcccc gtcggtgagc gcgtcggcgg aggcgccgag cccgaggcgt acggcgcgga
     1561 cgtcgcgtac cccggcggcg ctgagcaccc gtccggcggt ggtcgaggtg ccggactcgg
     1621 cggcgccgag ggagaccgtg cgcccggcca gctgggcggg gtgctcgatc gtggagtcgg
     1681 cgggtacgac caggtgcaga tagttgaggt acagccgggc gagggcggcg accggcatct
     1741 tccgccggaa gaggccgctc cccgcggcgg cgtccgccgc gctgtcggcg agggtgagcg
     1801 cgaggtcggc ccggccgtcg ccgagcatgc gcaggttctc cacgctcgcc gcggtggtga
     1861 gcacccgcac ggtgagcccg tggtgggcgc ggtgcgcctc ggtggcgagt ctgctgccga
     1921 aggtggcgta gggcccgccc cgcgggccgg tggccagccg cacccgggcg gagggcccgg
     1981 ggtccgaaca accggcgagc ccgcccgcgg cgagcgccag cagcaggcgg cgtgggacgg
     2041 tgtgcacccg gcgatgctaa ccgccggagt acgtactggt cagcgggcca gcgcgctgag
     2101 ctgggcccac accacgcggc cgccggccgc ccccggccgg tcgccccagg cctcggtcag
     2161 ggcgcggacg agggcgagac cgcggccgct ctcgtcctcc acgcccgctt cccggggcat
     2221 ggggccgagc gggccgccgc cctggtcggc gacctcgacg tacagcgagc gccgctcctg
     2281 ggcgcggagc acgcagagga tctggtcgct cgcggtgtgc acgagcgcgt tggtgaacag
     2341 ctcggacatc accagctcgg ccgcgccgca cacgtcctcg tcgaagcccc agtggggcac
     2401 ccggttccgg acgagccgtc gcgccgcggc gaccgaggca ccccgggcgg gcagttgcag
     2461 actctcctgg cggagagcca tgtcaacgcc ggcggagctc atgtgagggg ccatcgtcga
     2521 gcgttgacgc agtgccacgg ccatgtgcct tccgtccgtc tacctgtggg ggcgtgaatg
     2581 ccgcccgtcc gcgactgccg caagtgcgcg acaggacagc cacgttggga ccggtcacga
     2641 cgccactatc gttcctgcga gcatcagttg gcaaggcgcg ttctgcaaaa tgcagaatgg
     2701 ccaacgcagt ctgtgccgtc cacaccgagc atggcacact gagacgcaca acaccgtcgg
     2761 aggaggtatg acgtgggtga agcgcggtct gccccgaccg tcgggcagat ggtcctcggc
     2821 atgcggctgc ggcacctccg cgagcgggcc ggagtcagct atgacgcggc cgccaaggcg
     2881 ctgcatgtca accagaccac cgtgcgccgg atggagaagg ccgaagtcgg cctgaagctc
     2941 ccgtacgtcg agaagctcct gcggacctac ggcgtcgaac aggacgaggt ggagtccttc
     3001 ctcggactcg tcgaggaggc caacaggccc ggctggtggc accggttccg cgatgtgctg
     3061 cccgactggt tcagcctcta cgtgagcctg gagggcgccg ccagccggat ccgcgcgtac
     3121 gaaccgcact tcgtccccgg tctgctccag acggaggact acgcccgcgc gctgctgcgc
     3181 atcggcttcc cgcagggcac cgaggaggaa ctcgaccggc gggtcgcgct gcggatggag
     3241 cgtcaggagc tgctctccag acccgacggg ccgcatctgt gggccgtcat ggacgagacg
     3301 gtactccgtc tgcacatcgg cgggccgaag atcatgcgcg cccagatcga tcgcctcatc
     3361 gaggccgtcc ggatgccgaa tgtgaccctc caggtggtgc cgttcgccgc cgggccgcat
     3421 ccgggtatgg gcggcccctt ccaactgttc cggttccaga tcccggagct gccggacatc
     3481 gtctacgccg agggcctgac cggcgccggc tatctcgacc agcgcaccga ggtggccgcc
     3541 cacctggagg cactggaccg gatgggcacc caggccacat cggcgcggcg cacggagggc
     3601 tttctccgag agattcgcaa ggagctgtga ctgtggatca ggtagaagac gtctacaacg
     3661 gcatgccggc cacccgtctg gcgacggagg gctggcgcaa gccctggagc ggccccaacg
     3721 gcggtgcgtg cgtggaggcc ctgaggctgc acgacgggcg gatcgccctg cggcagtcga
     3781 cggaccccga cggccccgcg ctgatctaca cccaccatga gatggagaag ttcatccagg
     3841 gcgccaaggc cggtgccgcg gacttcctcc tcacccgacc cgaccccaac aacctggcca
     3901 cctcggcggc taacgcaccg gaacggaggg cggcgtgacc gactacggac tcgccccgga
     3961 ccagcagatc gacaccagca agccgcactc ggctcggatg tacgacttct acctcaacgg
     4021 caaggaccac tacgaggtcg acgcggaggc cgccggcaag gtgctgtcgg tctacccgac
     4081 cgtcaagctc aacgccaccg tcaaccgcgg cttcatccac cgggcgacgc gctggctggc
     4141 ggccgaggcg ggcatccggc agttcctgga catcggcacc ggcatcccca ccgagccgaa
     4201 cctgcaccag gtcgcccaga gcgtggcgcc ggaggcccgg gtcgtctaca ccgactacga
     4261 ccccatcgtg ctcgcgtacg cccaggccct gctgcgcggc acccccgagg gccgcaccgc
     4321 gtacgtccag gccgatgtgc gcgaaccgca gcggatcatc acggcgaccg agctgcggga
     4381 gacgttcgac ctgagcaagc cggtcgcgtt gtcggtgaac gcgctcttcc acttcattcc
     4441 ggaggaggag aagccgtacg agatcgtggc ggagctgatg ggcgcgctcg ccccgggcag
     4501 ctatctgatg ctgacgcact ccacggccga cttccacgcg gagacgtggc agaaggtgat
     4561 cgccgtctac aaggagagcg gcatatcctt cacgacccgc aaccggagcg aggtcgcggc
     4621 gttcttcgac ggtctggagc tggtcgaccc gggcgtctcg gagccgcacg cctggaagcc
     4681 ggaccccggc gaccgcccgg acgagatccg cagcgcggac atcaacatgt gggccggggt
     4741 ggcccgcaag ccgtagtggc gggtggtgcc gttacggctc ctcggggcgc cgttacggct
     4801 cctcggggcg ccgttacggc tcctcggggc cgtccacggt gaagcccagg accgcgccgc
     4861 cgccggggcg ggagcgggcg aagaccgtgc cgccgtgcgc gagggccacc tcgcgcacga
     4921 tggccaggcc cagcccggag ccgggcaggc tgcgggcgcc gggggcgcgg tagaagcggt
     4981 cgaagagccg ctcgcggtcc tcctccgcga tcccgggccc gcggtcgcgt acttcgacgc
     5041 ggtgcccggt caccacgacc tcgacgggcc cggtgccgtc ccggtcgaac ttggcggcgt
     5101 tctccaccag gttggagacc gcgcgcagca gggccgccgg gtggccctcg acgagggtgt
     5161 cgccctcggc ccgtaccgtg atgtcgcggc cggtgcgccg acgggcgagg gtcgcggcct
     5221 tggtggcgac ctcgtccagg gacacctccg tgcgcggttc gtcgtcccgc tgaccggccg
     5281 ccaggtccac cagctcgttg acgaggtcgg tcagttcccg ggtctccccc gccagatcgg
     5341 ccagcagctc gtcgcgcgcg gcgggcggca gctgctcgaa acggctcagc agcgagatgt
     5401 tggtgcgcag cgaggtgagc ggggtgcgca gttcgtgccc ggcgtcctgg acgaggcgcc
     5461 gctggtcgtc cttggagcgg gcgagccggc cgagcatgcc gtcgaacgcc cggcccagcc
     5521 gtcccacttc gtcgtccccg gcgaccggga ccgccacctc catccggccg gtgaccgcca
     5581 cgctctcggc gacccgggtg agccgtacca gccgccgggt gatgcgtccg gcgagccacc
     5641 acccggccag cccggcggcc acgatgatcg cgacgacgaa gagcgcggtg cgcttctgga
     5701 gttcgcgcag cagatcctcg gtgtcactga tctgctgggc cacctgcacg gcgccgcggt
     5761 ggtcgccgag cgcgacggtg gccatccggt agtcgtcctc gccgatggag atgttgcgct
     5821 gccgggtggt gcccgcggtg gctgccgcgg cggtctcccg gtcctcgtcg ccgaccggca
     5881 gcgcgggctt gcccttgtcg tagacgtcgc cccggccgcc cagcacctgg acgtccatgc
     5941 ggctgatccg gcgcaggtcg tcgcgcagcc cgtacggcac cgggacctcg gaggggtact
     6001 gccgcaggat caccttctgg ccgcggacct gggtccgcag atcgcggatg acgtcggtga
     6061 acgcggactt ctggtcgacc cgcaccagcc cggccgcggc gtcgtagctg aggaagccca
     6121 ccaggagggt caccacggag gccaccgccg cgaaggacag cgcgaaggtg gtgtgcaggc
     6181 tgggccgtgg atgacggcgg agggggaagc gcaccgttca ctcctcccgc agggtgtagc
     6241 cgacgccgcg caccgtgtgg atgagcgggg tgagcccgac ctggtcgacc ttgcggcgca
     6301 aatagccgat gtatacagcc aggttcttcg atccggggcc gaagtcatag ccccagatgc
     6361 gagagtagat cgtgccatga tcaagaacga tgcccgcgtt acgggccagc agctccagca
     6421 ggtcgaattc ggtgcgggtc agctccagtt ccgtaccgcc ccgccacacc cggcgcgccg
     6481 aggggtcgag ccgcaggtcg gcgacctcca gcgtggcgtc gaagacggtg ccctcccccg
     6541 cgggctccgg tatgggggcg gcgcggcgca gcagcgcgcg cagccgggcg aagacctcct
     6601 cgacgtcgaa cggcttggcc acgtagtcgt cggcgcccgc gtccagtccc tcgatccggt
     6661 cggcggtctc cacccgcgcg gtgagcatga ggatgggggt gcggtcgccc tcggcgcgca
     6721 gcacccggca cacctggatt ccgtccactc ccggcatcat cacgtccagc acgatcacgt
     6781 ccgggtgctc acggtggatg gccgccaggg cctcgacgcc gtcggacacc gcggtcaccc
     6841 ggtatccctc cagcgtcagg gcgcgctcca gcgcatggcg gatggcacgg tcgtcctcgg
     6901 cgagcagcac ggtgttggtc acacgacgag tctgccaagg cccgtcgggt gcggtccccc
     6961 gcatcccccc ggagctgcgg ttcttacccg gctctcaccg tatccacgcg accggcttac
     7021 cgagccggga cagggtaccc agtacgttcc ggggggatcg cgccccggtg ttgccaccgg
     7081 ccggagagac accgaatgaa gatcgtattc ctgctgcaca acgcttatgg gatcggcgga
     7141 acgatacgca ccacgctgaa cctcgccgcg gcgctcgccg agcgccacga cgtggagatc
     7201 gtctcgatga tgcgccaccg agggaagccg cgcttcacga tcgacccgcg ggtacggctg
     7261 gtgccgctgg tcgacacccg gcccggcggc cacgacgcgc gggatccgct gttcgcggag
     7321 cgcacccggg actttcccgt ccacgagaag cggaaccacc agtacaaccg gctgatggac
     7381 gtgcggatcg cccggtatct ggagggctcc gacgccgacg tgatcatcgg cacccggccg
     7441 ggcgtcaatg tgtacctcgc ccgcttcggc ccgcgcaagg ccctgcgcat cgcgcaggag
     7501 catctgcggt acgaggcgca cagcaagaag ctgcgcgccg agctggcgcc gtactaccgc
     7561 atgctggacg ccgtcgtcac cacgacggag gcggacgcgg cggtgtaccg ggcgaagatg
     7621 ccgctgccgg gggcgtggac cctcgcgata ccgaacagcg tccccgagcc cgcggccgcg
     7681 ccctccgagg gcaccgcgcc ggtgatcgcg gcggccgggc ggctggtccg cggcaagcgc
     7741 ttcgatctgc tgatagacgc cttcgcggag gtctcgccca agcatccgga gtggcggctg
     7801 cggatctacg gcggtggttc ccagaaggat cggctccagg agcgcatcga ggagctcgga
     7861 ctgaccggga gcgccgagct gatggggccg tactcgccga tcgaggagga gttcgcgaag
     7921 gcgtcgatcg tcgcggtcgc ctcggacgcc gagtcgttcg ggatgacgat cgtggaggcg
     7981 atgcgctgcg gggtgccggt ggtgagcacg gactgcccgc tgggccccgc cgagatcatc
     8041 gaggacgggg tcaccggacg gctcgtcccg gtcggcgaca agcaggcgat ggcgcaggcg
     8101 ctgcgggatc tgatcgacga cgagccgggc cgccgcgcga tggccgcggc ggcgctggag
     8161 agcgcgcgga cgtacgaccc ggagccgatc gccgtgcgct acgagcggct cttcgaggag
     8221 ctggcgtcga gccggttcgc gcgctcctgg gagcgcaccc gggtccggct gcgggccggc
     8281 taccgccgta aggtccgccg ctggaagcgc gccttccgcc gtcgtctgcc cgcggcgggc
     8341 gggaagagcg ccaaggcgtg actgcgggcc gggcggtgcc cgccgcccgg cctgcccgtc
     8401 gggatcacca ggtggtcggc gcgtagtcct tgaggaagca gccgaacagg tcctcgccct
     8461 gctcgccccg gacgatcggg tcgtagaccc gggccgcgcc gtccaccagg tcgagcgggg
     8521 cgtggaagcc gtcggccgcg agccgcatct tgtccgggtg cgggcgctcg tcggtgatcc
     8581 acccggtgtc gacgctggtc atgaggatgg cgtcgctttc gaacatctca cgggcgctgg
     8641 tgcgggtgag catgttgagc gaggccttgg ccatgttggt gtgcggatgg cccgcgccct
     8701 tgtagccgcg gccgaatttg ccctccatgg cggagacgtt gaccacgtac ttccgccggg
     8761 caggcgcggc ggccatcgcc gggcgcagtc ggctgaccag gatgaagggc gccgtctcgt
     8821 tgcacagctg cacctccagc atctcgaccg ggtccacctc gtggacccgc tggatccacg
     8881 tgttggtggg gtccaggtcc gggacgagcc cgcccgcgtc gatcgcggtg cccgcctcga
     8941 tccgggcggg cgaggcggag ccgcggttaa gggcgagggc cgtgaggtcc tggggggtca
     9001 gcgcaccgtc ccgctcccgg cgcggcccgg gcagcgcggt ctgggagccg ctgccgaagg
     9061 cgccgaggac gacggcctcg ggcagttccc cggcaggcag cggcgccgac tcgcccgcta
     9121 tcagctccgc gtacgcctgc ggggtgcggc gcacggtctg cgcggcgttg ttgatcagga
     9181 tgtccagcgg cccggcggcg ctcacctcgt cggccagcgc gatgacctgg gcggggtcgc
     9241 gcagatcgat gccgacgatc ttcagccggt gcagccactc ggcgctgtcc ggcatcgccg
     9301 tgaagcggcg gatcgcgtcg ttggggaagc gggtggtgac ggtcgtatgg gcgccgtcgc
     9361 gcagcagccg cagggcgatg tacatgccga tcttggcacg gccgccggtg agcagcgccc
     9421 ggcggccggt gaggtcggtg cgggcgtcgc ggcgggcccg gttctcggcg gcgcagccgc
     9481 ggcatagctg gtggtagaac gcgtcgacct cgacgtaccg ggtcttgcac acgtagcagg
     9541 agcgcgggcg ctccaggatg cccgcgatct cggtggtgac cgagctgctg agggcccggc
     9601 ccagcgtctc gtcgtcgatg cggtcggcgg cgccggtggc ggtggcctcg gtcaccgcct
     9661 tgtcgttggc ggtcttggcg gcccgccgct ccgagcgcct gcgctgcttc acggtgcggt
     9721 agatgcctgc ggtggcccgg cgcaccgtga tggcgtcggg gtggtcgatg ggcagccggt
     9781 ccagctcctc gaggacgctc aggcaggtcg ccaggcgctc ggggtcgata ccgggcgcct
     9841 cggcccccgt gtgctcagcc cccggctgcc cggctcccgt ctgctcggcc cggccgtcgt
     9901 cagtcaccgt catcgccgct gccgctttct ggttctgttc tccctgggta acggccgaac
     9961 tgtacggaag cggggacggt tgcgccaaac ccgggcggtc tcaccccctc ccgtacccgc
    10021 ggtacgtata gcccgggggc gggggctccg cggccggagc ggggccggtc agcgaacgga
    10081 tcaggccatg atcgggcgag agggcacagg ccgggtcggt gcgggcggcg tccccggtga
    10141 gcgcgtacgc ctggcagcgg cagccgccga agtcctcggc gcggtgggag cagctacgac
    10201 acggttcggc catccactcc tcgccgcggt agcggttgaa ggcggcggag tggtcccaga
    10261 tccactccag cgcgtggtcg cggacgttcg gcgggtcgag gccgggcagg gcggccgcgg
    10321 cggggcaggg caggacggtg ccgtcgggcg cgacggtgag cgagaccgcg ccccagccgc
    10381 ccatgcaggg cttggcgacg ccctcgaagt agtccgggag gacccacacc agctcggtgc
    10441 ggccgccgag cttctcgcgc catcgcgcga cgccctcccg ggcccgggcg agctgctcgc
    10501 gggtgggcag cagggcggcg cggttgcgca gggcccagcc gtagaactgg gtgttggcga
    10561 gttcgatgcg gtcggcgccc caggccacgg ccagttcgat caggccgtcc agggcgtcga
    10621 ggttgtcacg gtgcaggacg acgttgacgc ccagcggcag acccgcctcc cgtaccaggg
    10681 cggcggcccg ctccttggcg gcgaacgagc ggtgtcccgc gatccggtcg gaggccccgg
    10741 gggaggcgtg ctggacggag agctggacgc tgtgcagccc ggccccggtc agcgccgtca
    10801 gccgggcctc gtccagcccc acgccactgg tgaccagctg ggtgtagagc ccggcggacg
    10861 cggccgcggc gacgatcgcc tccaggtccc ggcgcagcag cggttcgccg ccggacagat
    10921 gggtgtggac gacgcccagc tccgccgcct ggcgcagcac ccgctcccac tcctcgccgg
    10981 tcagctcgcg ggagcggcgc accagttgga gcgggttgga gcagtagggg cagtgcagcg
    11041 ggcagccgtg ggtcagctcg gcgagcagcg cccacgggcg ggggtgggcg gtcccctggg
    11101 ggtgcccttg ggagtgctct tgggggtggg cggtcaccgt atccagccct cctcgtgcat
    11161 ccggcccagg aacgccggga cgtcggtggc cacgggggcg ccggggaagc gttcggcgag
    11221 ttcggccacg atggtgtcga ggtcgcggtc gccgtcgcac agccgcagga cggttccggc
    11281 ggtgccgcgc aggaccacga cgcgctcggg catcaccagc aggtccacct cgcgcacccg
    11341 gtcgtggcgc aggtgcaccg cgggggccag ggccggccgc caggcggccg gggccgtcat
    11401 gtcccctccc ccgccgtgtc cttggtgtcg gcgtggtcca cggcgtccag cagggaccac
    11461 agcacatcgc atttgaaggt cagcgccgcg accgcccgct cctcatcctc gggggtgcag
    11521 gcccaggtca gaacgaggtc gagggcttcg gcgctgtccc ggctgccctg gctcacccgg
    11581 tcccggaagt agcggagccc ttcgcgctcg atccacgggt agtggtgttc gaacgcctcg
    11641 atgcgggtgc gcatgatgcc gggggcggac agttcggtca gcgaggcggc gacggcctcc
    11701 agcggggtgc ccagacggca gaagttgacg tagccgtcga ccgcgagccg caccccgggc
    11761 agcacgtcgg cgccggtcag cagccgttcc cggccgatgc ccgcggcctc gccgagccgc
    11821 agccaccgct cgatgccgcc ctcgccgtcg gcggcgccgt cgtggtcctg gatgcggcgc
    11881 agccacatcc ggcgcagccg cgggttgtcc agcttggcgg tgatgagcgc gtccttgacg
    11941 gggatgtggc gctggtagtg gaagcggttg aggatccagc ggcgcagttc ggcgggggtg
    12001 agttcgcccg cgtgcatgcg gaggttgaag gggtgccggt cgtggtagcg ctcctgggcg
    12061 acggcgcgca gccgctcttc gaggctccgg gtcataactc gatcaccatc ccgtcggcgg
    12121 ccacctcgat gccccgtccg gcgagcaccg cgtgctgggg cgcggccggg tcgttgaggg
    12181 ggttggtgtt gttgaggtgc gtgtacaggg tgcgggcgcc gagtgcggcg agccgcggtg
    12241 ccgtgccgcc gggtccttcg atcggcagat ggcccatggc ggtggcggtg cgggagccga
    12301 agccgctgcg caggggctcc tcgtcgtccc agaaggtgcc gtcgacgatg acgcagtcgg
    12361 cgtcctcggc ggcccgctgg aaggcgtcgg gccaggcggc gagggcgggg gcgtagagga
    12421 gggagcggcc ggtggcgcgg tccgtcaggc gcagggcgac gacccaggcg ccctcgtcgt
    12481 ggccgtccaa cccggcggcg tagcgggggc gtttggcgga gacggggacg gcggcgatgg
    12541 tgaggtcccc gtcctcggcg aggggccggt cgccgggccc gaggtcgtcc cagtccagtg
    12601 cggcgtaggg ggtcaggacg tcgccgaggc ggagtccggt cagcagggcg tgccgtaccg
    12661 gggcggtggc cacgatccgg atgcggtccg cctcgcgcag ccgggcgatg ccgagggtgt
    12721 ggtcgagttc ggcgtcggtg aggatcaccc cggccagcgg ggtgtggcgc ggttcgggtc
    12781 cggggtgcag ttcggggcag tcctcgacct ggtcgccgag gtcgggggtg gcgttgacga
    12841 ggtaccagcg gccttctgcg gcccgtacgg cgagcgaggc gtggcggcgg cgccgctccg
    12901 ggtgggcgcg tgccccggag catccggggc acgcgcagtt ccactggggt acgccgccgc
    12961 ccgccgcggt gccgagcaca cgcacgcgca tggcggctgc cgtcagcggg cgttgagtga
    13021 gtacgcggtg acctccagcg cggtctcgac gaccacgtag tcgggggtct gccaggctgt
    13081 ttccggtgcg ggggtccggg tgtggtccac cgcctcggga gccgtctgcc gcacggtttc
    13141 gttcatggca ttgacctgcc ttccggtttc cgggtgtcgg gttgggccag agggtgtctc
    13201 ggcgggacgt cagccggtgg tcctgatccg cagcgcctcg ccgtcggtgg tggtgccgtg
    13261 ccggaccacg gggccggtga cgccgctgaa gcccacgtcg tacgggctgg cggtgccgcg
    13321 ccgggccgtg acccggtcga gagtgatgcc taccccgtcg tccgcgatga acgcgggccg
    13381 gtcgtcgttg gtgtcggtcg tgacggcgct gttggtgaag gtgatgtcct tggcatgccg
    13441 gatccaccag ccgtaggagg ggcgtacccc ataggtcttg gggacgtagt cggtgaggta
    13501 ctcgccgggg acgagttccg cgtcggaggc ggggtggccg ccgggcacgg ccagccgcac
    13561 ccggtcgaag gtgatgtccg taacgtccgc gccgggcgct ccggtgatgg tgctggtgta
    13621 gtcgacgccg gtgaccgggt gggtcagccc ggtgccggtg acgtggctga agcggatgtc
    13681 gtggatccgg ccggcgggcg gggcgcccgg gcagcgctta cggtcgccga tcttgatgaa
    13741 gacgggggtg gcgcccttgg tcatggtgat gtccgagtag cggacgtcgc cgatgtcggc
    13801 gccgtccatg gagacgatgc cgatggccgc cttgcccccg ccgccgatcc ggagccggtc
    13861 gaagcggatg tcgcggaagt cgccgcaggt ctccgagccg aactggaggg cgttgttctc
    13921 ggtggacagc acatcggagt catggacccg gatgtcatgg ctggtgtagg tccggccgag
    13981 cgcgtagtcg ctcttgagga cgacgccgtc gtcccggccc tcgatgcggg agtggccgat
    14041 gtcgacgtgg cggctgttga tgaggttgac ggcgtcccgg tcggtgctgg tgagcacctt
    14101 ggtgcgggtc atccgcaccc cgtcgcagcc gttgagcagc agcgcgaagt ggccgccccg
    14161 ggtgaaggtg acgtcctcga tgtccaggtc ggtgcagcgc ttgagggaga ggatcttgtc
    14221 gccgacgccc ggttccaggg tgttgctggt gcccagcccc tcgccgtcga gggtgccgga
    14281 gccggtgatg gcgaggtggt ggatgttctc gcccgtcagc agcgcgttgc ggaagtggct
    14341 gtggccgaag tcctggtagg cgtcccaggg gttgggctcg gcctcgtcca tgcccccggc
    14401 ggcggcgagc agcgtcgcac ccttggcgag gtgcagggtg atgtcgctct tgaggtggag
    14461 ggtgcgggac ttgtaggtgc cgggcgggaa cagcacggtg ccccggccgg gagcggcggc
    14521 tgccgcgtcg atcgcccggt cgatggcgtc gtcgtccagg gtcgtgccgt cgcccgtggc
    14581 cccgtagtcg cgcacgtcgt acgtcctggc ggttcccccg gccgcgcctg cgtccggggg
    14641 aaccgcggcg agcacacacg ccgcggccgc cgtggcggcg gcgaagcgca ggcgtgtcca
    14701 tcgcgtcatg aggcgccctt cgggtctcgg ggtgcggtca ggtgccgttc tgtcgcacag
    14761 tcacttctgt tgcagcgtca ctgcctgtcg gtgtccggtc aagaagcgcg cagctaaaat
    14821 cctccgatct ctcgcgatgc gcatggggta cacagctcaa ggaaacaagc ggaatgtgca
    14881 ggtagctgtg ggggcgaggc gtgaggaacc cgaggtgacc acccttcctg gtccacacca
    14941 ttccttgact cgttacgcca tacctcctac cttcacagct ccccccatgt gaacaaggat
    15001 cagacaggag aatccttgat ggagcgccca ccgctcttac cgcgcaccgc cctcaccctc
    15061 gcggccaccg ccgcgctgat cgctccggcc gcggtcgcct acggcaccga gcgctccccg
    15121 caggcgccgg ccgcgtcctg gagcctcaag tggaaccccg cctcgggcgc gagtgtcgcc
    15181 agcgccttcg agggcgccga ggacgaccgc gccgactccc accccggcac cacccacatc
    15241 tacccctccc agggcggttt ccggaccgac atgcactacc ccagggacgt ggacaccagc
    15301 accgaccgcc agcgcaacga ggtacggggc atgaagcagg acggctccgc cgtcaagatc
    15361 ctcaagaacg agacctggcg gatccagtac cagatgtacg tgccggacac gctcgacgcg
    15421 accacgagct tcacccacat catgcagatc aaggtcgggg acgtggccgc cccgctgttc
    15481 accatgtcgc tgcaccagca cggcgacggc ccgaaggtcg aaatccggac ctcggacgac
    15541 gacgagaacc tgaccgaggc cggggccgcg aacatgtcgc cgctccaggg cgcctggagc
    15601 gatgtgtcgg tcgaggtcaa ggcggccgac tcgggcgcgt acgccgactg gtcggtgacc
    15661 accggcggaa agaaggtcgc cgcgcacaag cgcaccggcc tggacctgtg gcgcggcaag
    15721 aactacctgc ggcccaagtg gggcatctac cggagcctga acagcggcgg cctccagacc
    15781 acgtacctgc tcacccggaa cttcaaggcg tacaagctcc agtaggagga cacgcgatga
    15841 agagctgtcg gaacaccctg gtggccgcgg ccgccaccac cgcgctcact gccgggctgc
    15901 tgctcaccca ggcgggcacc ggcaacgccg caccggccgc ggccgattca gcccgttcgg
    15961 ccccttcggc catcacgacc gtctcgtccg gctggtcgat cccctggggg ctgagctggc
    16021 tgccggacgg ctcggcgctg atcaccgagc gggactcgtt caaactcttc aagctcaccc
    16081 agtcgggcac caagacccag gtgggcacgg tgcccaatgt ggtgacgacc agcggcgagg
    16141 gcgggctgat gggcctcgcg gtctccccga actggaacac cgatcactac gtctacctca
    16201 tgcacacggc gtcggacggc aatcggatcg cccgcatgac ctacgacggt tccaacgtga
    16261 gcggctacaa ggcgatcgtc accggcatca agaagaacaa gtaccacaac ggcgggcgcc
    16321 tcaagttcgg cccggacggc tatctgtacg ccaccaccgg ggacgcacag acgaccagca
    16381 acgcgcagga caagaactcg ctcaacggca agatcctgcg gatgaccacc gacggcaagg
    16441 ccgcccccgg caacccgttc ggcaccctcg tctactccct cggccaccgc aacccgcagg
    16501 gcctcacctg ggacgcgcag ggcaggctgt gggaggcgga gctgggcaac agcacgtacg
    16561 acgaactcaa cctcatcgag gcgggcaaga actacggctg gcccacctgc gaaggcagct
    16621 gctccacctc cgggatgacc aaccccaagc gccagtggtc cgtcggcgag gcatcgccca
    16681 gcggggtcac ctacgccgac ggcgccctct acatggcggc gctccggggc gagcggctgt
    16741 ggcggatccc ggtcgacggg acgagcgcgg gcaccccgaa ggcgtactac accagctcgt
    16801 acgggcggct gcgcaccgtc gagacggtgc ccggcaagaa cacgctgtgg ctgtccacga
    16861 cgaacgccga caacaacggc ggggagccgg acggcgcgga caaggtgttc caggtcgagc
    16921 tgaagtagca cgcgccgcat gcgtacggtc gcgctccccg gggagcgcga ccgtacgccc
    16981 gtgtcagtac gccagccgct cgttcatcag caggaaggcg cccaggccat ggaggtcgtt
    17041 ggtattgcgc gggcggccga ggtagtaggc cagatcaccg acgttggtgc cctcgctgat
    17101 gtcggcgatg ttggtcagcc cgtccgcgcc caccgtcacc ttgtccagga cgccccggta
    17161 accgcggcgc gccgccgccg cgtagtcgcc accgcggatc cagccgtgcc ccagggcggc
    17221 gtgcagcatc agggtgtaca tgctggaggc cgaggtctcg gtccagttgc ccggctcgcc
    17281 cgccttgtcg acgacctgga accagcggcc ggtcgcccgg tcctggtagc gcaggaaccc
    17341 cctggccaag tgccgtacgt tggcgatgag ttcggcgcgg cgcggatggc gggcgggcag
    17401 catctccagc acctcgatgt gcgtcatcgc ggtccagccg atggcgcgcg cccagaagtg
    17461 ggcggaggtg ccggtggtgg cgtccgggtt ccagggggcg tcgccgtccg cgtcgtaggc
    17521 gtggtagatc agcccgttcg acgccttgag gtggcggaag tacaccgaga ggttccgggt
    17581 gacctcgtcg tacgcgtaag ccttgtcccc gtacgcgatg ccgtaccgca gcaggaacgg
    17641 ctgggccatg aagacgccgt cgccccacag ttcgttggtc ttgccggtgg cgtgccacat
    17701 gccgccgtcc gcggtgcggg gatagtcggc gaagcgggcg cggatctggc cggcggccgt
    17761 ccggtagcgt gcgtcgccgg tctcccggtg gagcatcagc agcaggttgc cggactgcat
    17821 ggcgtcgagg ttgtcgaagg tgcggctcat atggccgtcg gcatccacga atttgtccac
    17881 ccagcgcttg atgtacgcca ggtacgaggg ctcgcccacc cgctggtaga cgcggtacgc
    17941 ccccagcagg aacagccccc gggtgtagcc ccagccgccg agcgaggccg ggtcagggta
    18001 gcgggcgatg gtggagtcca ccaccgcccg cgaccagtcg gtccgggctg ccgcgtgggc
    18061 cgtcccggtc cccggcagca gaaggccgcc gccgatgccg agcgcgctcg cgagtacggt
    18121 cctgcgtctg atcatgggga gttccctctt ttcagttcag gatgccatgt acacgccaag
    18181 gatagcgtcg ggcgcaccgt accggggcaa acgcggagga aagggccgga tccgcatccc
    18241 ccgtcagcag cccggtcacc gggcgcgcgg ccgcgatgag gtccacgccg agcccgcgga
    18301 ccagctcgcg ggaccagatg cccgccgacg ccccccaggc gaacaccgac ccgcgagggc
    18361 acgccgaaca cccacacagg ctaaggtaag gctcacctaa gtctctggag tcgtcgtgcg
    18421 caacccccgt ctgttccccc tgctcaccac cgccgccctg gccgcgaccg tcctcaccgg
    18481 ctgcggcccg gcggagtccg cggactcgtc gtcggcgtcc gcacagcggc cgggcgcccg
    18541 gcaggcggac ggctccttcc cccgcaccgt cgtccacgaa ctcggcagca caccggtcaa
    18601 ggcgaagccg aggcgcatcg cggtcgtcag caccggccag ctcgacgatc tgctcaccct
    18661 cggcctcgtg cccgccgcca ccacccgcgc cgacaacgcc gggctggtac cggactatct
    18721 gcgcgacgcc ttccccggca aggcgaaggc gctcgcggcg atgacggaca tcggcacccg
    18781 ctcctccccc gccctggaga agctcgcggc cgcggggccc gatctgatcc tggtcaacag
    18841 cacccagggc gacctgtacc ccaccctgtc ggccatcgcc ccgaccgtcg tcaccaaggg
    18901 ccgcggggtc aactggaaga aggacctgct gacggtcgcg gacgcggtcg gcgagcgcga
    18961 ccgggcgcgt acggtcgtca gccgcttcga gaaggacgcc gcgcggcagg gcaggaagct
    19021 gggcgggaag gacacggagc tgtccatggt gcggttcaac ccggaccggg tccggatgtt
    19081 cggcgcgaag tccttcaccg gcaccatcgc cgacgacatg gggctcggcc gcccggcgtc
    19141 gcagaggttc gacgacatct cccaggatct gagcggtgag cggatccccg agatggacgg
    19201 cgactggatc ttctactcca tccagggccg ccccggaaag acggacgcgg gcgcctatct
    19261 ctccaacccg ctgtggaaga agctcgacgc ggtgcgcgcc ggacacaccg tcacggtgga
    19321 cgacgacccc tggtacctca acgccgggcc gaccgccgcg cgtgtcgtcc tcgacgacat
    19381 caccgagcac ctgggccgtt gacgcggacc cagctcgacg agctgcgcgg gcccggggac
    19441 gttcgcgacg gttatgggga aggcatatcc caccgtcaca ccccgtatgc gatcgggaca
    19501 atccgtcacc ataatgcccc ccacaggcaa tagtctcggc atacaggccg cggcggagga
    19561 ggtagcccat ggggacgggc gatcgtgaac aggcacaggc acgagcgcgg caggaagccg
    19621 accggctcac cgcgcagggc atccatggca tcgccctgac ctgggtggac aacgcgggcc
    19681 tcacccgggt caagtccgtg cccaccgggc ggctcgccca cagcgcacgg cgtggcgtcg
    19741 gcatgtcccc cgtcttcgac gtgtacctcg tggacgactc catgacgacg agccctcata
    19801 tcggcgggcc cgacggcgat ctgcggctct tccccgatct cgaccggctc accgtgctgg
    19861 ccgcccagcc cggctgggcc tgggcaccgg ccgaccgcta cgcccagtcc ggcctggaac
    19921 accccacctg ccagcggctg ttcgcccgcc ggatggccga gcgggcccac gggcgcggca
    19981 tcgcgctgcg catggggttc gagacggagt ggatcgtcac cacgggcggc acggacgccg
    20041 cgggcggcac cggcgcgccg cgctccgcgc gcgacacgcc cggcccggtc ccgtacgacg
    20101 ccacccccgg cccgcgctac gccggtacgg gcccggccta tggcatggcg cgcctggtcg
    20161 acctctccgg ctacctcgcc gacgtgctcg acacgctgca cacccagggc gtggaggtgc
    20221 tgcaactgca tccggagtac gcggccgggc agttcgaggt gtccgtggcg cccgcggacc
    20281 cggtgggcgc cgccgatctc gccgtcctcg tccgcgaaac gattcgcggg gtgtcggcac
    20341 ggcacgggct gaccccgctg ttcggcccgg tcgccgaggc gggcacggtc ggcaacggcg
    20401 gccatctgca cctgagtctg tggcagggcg agcgcaatct gtgccgggac ggggacggac
    20461 cgcacggcat gaccgcgacc agcgaggcgt tcctcgccgg agtgctgcgc gccctgcccg
    20521 ccctgctcgc catcggcgcc ccctccccgg cgagctatct gcggctggaa ccctcccgct
    20581 gggccggggc gtaccagtgc tgggggctgg agaaccgcga ggccgcgctg cgcttcatca
    20641 ccggcgcccc ggacgacccg ggcggggcca acgccgaggt caagtgcttc gacccggccg
    20701 ccaaccccta tctggtgacg ggcgcggtca tcgccgccgg gctcgccgga ctcgacgccg
    20761 ggctcaccct gccgccaccg gtctccggcg acccggcacg aacggaccgg gagcggcggc
    20821 tgcccacctc gctgcccgcc gcgctggagc acttcgagga ctcggcggtg ctgcgcgagg
    20881 cgctgggcga tccgctcttc gagtccatcg ccgccgtacg ccgcgccgag gcggcgctgt
    20941 tcgagaaggc cgccccgcag gagatcgcgg ccgcgacccg gggacggtac tgaacgatgc
    21001 gcaccgccga ggggacggcg ccgaccgggc tgtccctgcc accgctggtg gaccaccact
    21061 gtcatggggt ggcccgccac gaactggacc ccgccgcttt cgaggcgttc ctgaccgagt
    21121 ccgacgcgcc cgccgcgctc ggcaccacct tcttcgacag ccagctgggc ttcgcgctgc
    21181 gccgctggtg cccgccgctg ctcgacctgg aaccgcactg cccgcccgcc cgctacctcg
    21241 cccggcggcg ggagctgggg gtacgggagg tcaaccggcg gctgctgagc gccgccggga
    21301 tcaccgattt cctcgtcgac accggcctcc ccggcgatct caccaccccg gacgagctgg
    21361 ccgcggcggc cggtggcacc gcgcacgaga tcgtccggct ggaacacctc gcggagcgga
    21421 ccgccgacac ctcgcgcagc gccgacgact tcctgaccgg gctcgccgac gggatccggg
    21481 aggccgcccg taccgccgcg ggcttcaaat cggtggccgc gtaccgctac ggcctccact
    21541 tcgagcccga tccgcccgcg cccgccgccg tgcacaccgc ggccgagcgc tggctcgccc
    21601 accgcgccga gggcggcccg cccgccgccc gggtgaccga ccccgtactg ctgcgccatc
    21661 tgctgtggtc cgcggcccac accgggctgc cgctccaact gcacaccggc ttcggcgatc
    21721 cggacctgcg gctggaccgc tgcgatccgc tcgcactcac cgacttcatc cgcgccgtgc
    21781 gccccaccgg ctgctcgctg atcctgctgc acggctatcc gtaccaccgc ggcgcggcct
    21841 acctcgccgc cgtcttcccg catgtctacg ccgacgtcgg cctgtccctg acccacaccg
    21901 gggcgcgggc cggggccgtg ctcgcagaga tgctggagct gggtcccttc ggcaaggtgc
    21961 tgttctccac cgacgcctac gggctgcccg agctgtacgt ggtgggggcg cggctgttcc
    22021 gggaggcgct ggccgggctg ctggaccagt gggtgcgcga gggcgcgtgg tcgagcggcg
    22081 acgccgggcg ggtgg
//
