LOCUS       NZ_CP058693            24626 bp    DNA     linear   CON 08-SEP-2024
DEFINITION  Streptomyces sp. Rer75 chromosome.
ACCESSION   NZ_CP058693
VERSION     NZ_CP058693.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Rer75
  ORGANISM  Streptomyces sp. Rer75
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Genome analysis of Streptomyces sp. Rer75
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10474412)
  AUTHORS   He,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-JUL-2020) College of Pharmacy, Henan University of
            Chinese Medicine, Jinshui East Road No. 156, Zhengzhou, Henan
            450046, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. Canu V1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 76.63x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013414305.1-RS_2024_09_08
            Annotation Date                   :: 09/08/2024 05:25:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,857
            CDSs (total)                      :: 8,765
            Genes (coding)                    :: 8,460
            CDSs (with protein)               :: 8,460
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 305
            CDSs (without protein)            :: 305
            Pseudo Genes (ambiguous residues) :: 0 of 305
            Pseudo Genes (frameshifted)       :: 145 of 305
            Pseudo Genes (incomplete)         :: 204 of 305
            Pseudo Genes (internal stop)      :: 20 of 305
            Pseudo Genes (multiple problems)  :: 62 of 305
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:27:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 117189
            Orig. end                         :: 141815
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058693.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24626
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azoxy-crosslink"
                     /region_number="1"
                     /rules="(azdH and LPG_synthase_C and azdO and vlmB)"
                     /tool="antismash"
     cand_cluster    1..24626
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(azdH and LPG_synthase_C and azdO and
                     vlmB)"
                     /kind="single"
                     /product="azoxy-crosslink"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24626
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:14626]"
                     /cutoff="20000"
                     /detection_rule="(azdH and LPG_synthase_C and azdO and
                     vlmB)"
                     /neighbourhood="10000"
                     /product="azoxy-crosslink"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14626
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(azdH and LPG_synthase_C and azdO and
                     vlmB)"
                     /neighbourhood="10000"
                     /product="azoxy-crosslink"
                     /protocluster_number="1"
     misc_feature    118..127
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    292..301
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            complement(1121..2404)
                     /gene="serS"
                     /locus_tag="HYQ63_RS00475"
                     /old_locus_tag="HYQ63_00475"
     CDS             complement(1121..2404)
                     /EC_number="6.1.1.11"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004828 - serine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006434 - seryl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="serS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521927.1"
                     /locus_tag="HYQ63_RS00475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00475"
                     /product="serine--tRNA ligase"
                     /protein_id="WP_179931991.1"
                     /transl_table=11
                     /translation="MHDLQDLVRPDASVEWRLRRRHHYLDLEALRKLTKQRAEAISRRD
                     SLRAALNKVSRTMAERPDARTPEDMAAAKGLKESIREAEVSQRAAEAQLDAALLAIPNV
                     PSDEAPDGGPEDPPVEVQSWGRAPAFHFEPRDHVELASSAGILDLQRASKLSGARFAVF
                     RGAGAALERALVSFFLDLHTKEHHYSEHSVPYLVNPQSMTGTGQLPKFTEDLFATQVAG
                     RSLYLIPTAEVPLVNLYAREMIDADALPLGLTAHTACFRAEAGSYGRDTRGVIRLHQFS
                     KVELVRFCLRSEATAQLELLLSHAEECLQRLDLHYRVVDLRAADLGFSARRTYDLEVWL
                     PSQNCYREVSSVSDCGDFQARRAGIRVRRGKTKEYVATLNGSGLPIGRTIVAILEQNQR
                     QDGSVEVPAALVRYTGFRLIKPDGTTEG"
     gene            complement(2435..3934)
                     /locus_tag="HYQ63_RS00480"
                     /old_locus_tag="HYQ63_00480"
     CDS             complement(2435..3934)
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135867.1"
                     /locus_tag="HYQ63_RS00480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00480"
                     /product="MmgE/PrpD family protein"
                     /protein_id="WP_179931992.1"
                     /transl_table=11
                     /translation="MTAHPGTAEVRHTQLSALADWASSLELDDVPERVRAFAASHVLSQ
                     LAAIRTGLGQEDGRRLVLALGEPLQQDVAQSARVLSGAGAWLNLDDTAYAGHLGPSTVG
                     VSLAYVYHLGLAGADLLRAVILADECAARITAAATLGPFRGQTALHTHVVGAVAARLAC
                     QRATAAEWAQALALALSAPPWTLMRGFLTSDARLLHVPVGVRMGLDACDAALGGLRGAE
                     DLLEHADGFLAQFAEVPLPETVTLGLGKRWHTETLSFKLHPGGPGIDAAIDCAADLHGR
                     MGQWRVDDVSEVVVECSMYTLWAARKAEPYLNGANTPVGALVLTTPYPLATALLKGALS
                     IEDFSHPAVDGADRWALAAKVRLVHDPEMTRTLMLGDAPFGEALRQAGALSTAWLHSFG
                     GPELADLVGPLDGPLDHFEDTAKPTPARVTARMIDGRSYTCQYSVPRGAIGPDLRARHQ
                     ELVAEKFRGVGGPDTVITAWPQLAEADPARLAGLIEEALAE"
     misc_feature    complement(2933..2935)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2969..2971)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(3728..3730)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3940..4917)
                     /locus_tag="HYQ63_RS00485"
                     /old_locus_tag="HYQ63_00485"
     CDS             complement(3940..4917)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020550394.1"
                     /locus_tag="HYQ63_RS00485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00485"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_179931993.1"
                     /transl_table=11
                     /translation="MDRGDLLNKNGSLPLRNRHVTIVANPAAGSTTRDRVAEMKSLCRI
                     FSDSVDVWWTECQGHATAIVAQLVDGESHAGPPDMIVSVGGDGTLREVVEGMARSACRI
                     PLVVMPGGTGNSNYRSLWDDVPWGTALESALTLRGAELRYLDLARVDGLDRIVVLGVST
                     GLFAEATAESRSVLVGGRDKYQQAISRVLNTFEPYMGRVVVDGRVVHSGLTTLVNVGGG
                     RHRAGVYNILPRSVRDDGLLDVCVLDAAVPPLTMLDLTRSGDHLGREGVTYARGRRVTL
                     ERTDGLPLRFESDGEALESDLSSITVEVLLGGFPAFTHHLRPGG"
     tRNA            complement(4946..5031)
                     /anticodon=(pos:complement(122182..122184),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HYQ63_RS00490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HYQ63_00490"
                     /product="tRNA-Asp"
     gene            complement(4946..5031)
                     /locus_tag="HYQ63_RS00490"
                     /old_locus_tag="HYQ63_00490"
     tRNA            complement(5069..5154)
                     /anticodon=(pos:complement(122305..122307),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HYQ63_RS00495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HYQ63_00495"
                     /product="tRNA-Asp"
     gene            complement(5069..5154)
                     /locus_tag="HYQ63_RS00495"
                     /old_locus_tag="HYQ63_00495"
     tRNA            complement(5192..5277)
                     /anticodon=(pos:complement(122428..122430),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HYQ63_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HYQ63_00500"
                     /product="tRNA-Asp"
     gene            complement(5192..5277)
                     /locus_tag="HYQ63_RS00500"
                     /old_locus_tag="HYQ63_00500"
     tRNA            complement(5315..5400)
                     /anticodon=(pos:complement(122551..122553),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HYQ63_RS00505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HYQ63_00505"
                     /product="tRNA-Asp"
     gene            complement(5315..5400)
                     /locus_tag="HYQ63_RS00505"
                     /old_locus_tag="HYQ63_00505"
     tRNA            complement(5438..5523)
                     /anticodon=(pos:complement(122674..122676),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HYQ63_RS00510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HYQ63_00510"
                     /product="tRNA-Asp"
     gene            complement(5438..5523)
                     /locus_tag="HYQ63_RS00510"
                     /old_locus_tag="HYQ63_00510"
     tRNA            complement(5561..5645)
                     /anticodon=(pos:complement(122797..122799),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HYQ63_RS00515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HYQ63_00515"
                     /product="tRNA-Asp"
     gene            complement(5561..5645)
                     /locus_tag="HYQ63_RS00515"
                     /old_locus_tag="HYQ63_00515"
     tRNA            complement(5683..5768)
                     /anticodon=(pos:complement(122919..122921),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HYQ63_RS00520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HYQ63_00520"
                     /product="tRNA-Asp"
     gene            complement(5683..5768)
                     /locus_tag="HYQ63_RS00520"
                     /old_locus_tag="HYQ63_00520"
     tRNA            complement(5806..5891)
                     /anticodon=(pos:complement(123042..123044),aa:Asp,seq:gtc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HYQ63_RS00525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HYQ63_00525"
                     /product="tRNA-Asp"
     gene            complement(5806..5891)
                     /locus_tag="HYQ63_RS00525"
                     /old_locus_tag="HYQ63_00525"
     misc_feature    complement(6230..6240)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
     gene            complement(6321..7337)
                     /gene="ilvC"
                     /locus_tag="HYQ63_RS00530"
                     /old_locus_tag="HYQ63_00530"
     CDS             complement(6321..7337)
                     /EC_number="1.1.1.86"
                     /codon_start=1
                     /gene="ilvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153919.1"
                     /locus_tag="HYQ63_RS00530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00530"
                     /product="ketol-acid reductoisomerase"
                     /protein_id="WP_179931994.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 6.3e-07, bitscore:
                     27.9, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELFYDDDADLSIIQGRKVAILGYGSQGHAHALSLRDSGVDVRV
                     GLHEGSKSKAKAEEQGLRVVSPAEATAEADVIMILVPDPIQAKVYEESVKDNLKDGDAL
                     FFGHGLNIRYDFIKPSANVDVCMVAPKGPGHLVRRQYEEGRGVPCIAAVEQDATGNAFP
                     LALSYAKGIGGTRAGVIKTTFTEETETDLFGEQAVLCGGTAALVKAGFETLTEAGYQPE
                     IAYFECLHELKLIVDLMYEGGLEKMRWSISETAEWGDYVSGPRIINDSTKTEMKKILGE
                     IQDGTFAKNWMAEYNAGLPKYNELKKADEDHLLETTGKELRKLMSWVSDTEGTHTHR"
     gene            complement(7369..7893)
                     /gene="ilvN"
                     /locus_tag="HYQ63_RS00535"
                     /old_locus_tag="HYQ63_00535"
     CDS             complement(7369..7893)
                     /EC_number="2.2.1.6"
                     /GO_function="GO:1990610 - acetolactate synthase regulator
                     activity [Evidence IEA]"
                     /GO_process="GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="ilvN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925060.1"
                     /locus_tag="HYQ63_RS00535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00535"
                     /product="acetolactate synthase small subunit"
                     /protein_id="WP_179931995.1"
                     /transl_table=11
                     /translation="MSKHTLSVLVENTPGILARIAALFSRRGFNIDSLAEGVTEHPDIS
                     RITIVVNAKEPLLEQVIKHITKLVNVLKIVELEPGTSIQRQLVLVKVRADNETRSQIVE
                     IVQLFRAKTVDVSLETITIEATGTSDKLEAMLKMLEQFGIKELVQSGTIGIGRGSHSLT
                     TSAVHGLKRVA"
     misc_feature    complement(7883..7896)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     gene            complement(7929..9779)
                     /locus_tag="HYQ63_RS00540"
                     /old_locus_tag="HYQ63_00540"
     CDS             complement(7929..9779)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0003984 - acetolactate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714819.1"
                     /locus_tag="HYQ63_RS00540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00540"
                     /product="acetolactate synthase large subunit"
                     /protein_id="WP_179931996.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.7e-53, bitscore:
                     179.1, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.1e-48, bitscore:
                     161.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQPGAFHTPQSLPRTAERSSAVEHVTGAQSLIRSLEEVGADTV
                     FGIPGGAILPAYDPMMDSAKVRHVLVRHEQGAGHAATGYAQATGKVGVCMATSGPGATN
                     LVTPIADAHMDSVPIVAITGQVASKAIGTDAFQEADICGITMPITKHNFLVTKAEDIPR
                     TIAEAFHIAATGRPGPVLVDIAKDALQAKTTFSWPPQTDLPGYRPVTKPHAKQIREAAR
                     LIAQAERPVLYVGGGVVKAHATAELRVLAELTGAPVTTTLMGLGAFPDSHEQHLGMPGM
                     HGTVAAVTSLQKADLIVALGTRFDDRVTGKLDSFAPYAKIVHADIDPAEIGKNRAADVP
                     IVGDAREVIADLVVAVQAEHDAGHTGDYSGWWEDLNRWRETYPLGYDLPEDGSLSPQQV
                     IQRIGELAPEDTIFAAGVGQHQMWAAHFITYDKPATWLNSGGAGTMGYAVPAAMGAKAG
                     VPDRTVWAIDGDGCFQMTNQELVTCALNNIPVKVGIINNGALGMVRQWQTLFYNQRYSN
                     TVLHSGPGADAGQPSAGTRVPDFVKLAEAMGCIGIRCEDPADLDAVIEKANAINDRPVV
                     VDFIVHEDAMVWPMVAAGTSNDEILAARDTRPDFGDSEDD"
     misc_feature    9776..9791
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.43"
                     /tool="antismash"
     gene            complement(9803..9967)
                     /locus_tag="HYQ63_RS00545"
                     /old_locus_tag="HYQ63_00545"
     CDS             complement(9803..9967)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYQ63_RS00545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYQ63_00545"
                     /product="hypothetical protein"
                     /protein_id="WP_179931997.1"
                     /transl_table=11
                     /translation="MTTLQNPTEVLDDAQQRLAAFFVQLCADPDDSAAAQGADEALHQL
                     DALLASVDE"
     misc_feature    complement(10000..10010)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 20.07"
                     /tool="antismash"
     gene            complement(10001..11014)
                     /locus_tag="HYQ63_RS00550"
                     /old_locus_tag="HYQ63_00550"
     CDS             complement(10001..11014)
                     /NRPS_PKS="Domain: LPG_synthase_C (20-317). E-value: 1e-58.
                     Score: 190.6. Matches aSDomain:
                     nrpspksdomains_HYQ63_RS00550_LPG_synthase_C.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azoxy-crosslink: LPG_synthase_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007269071.1"
                     /locus_tag="HYQ63_RS00550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00550"
                     /product="DUF2156 domain-containing protein"
                     /protein_id="WP_179931998.1"
                     /sec_met_domain="LPG_synthase_C (E-value: 1.5e-56,
                     bitscore: 190.6, seeds: 74, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSQTLETDSQASAEYVLSAIQEHSQAENPSSFLAVNEGNSYFTL
                     PGRPGVIVYRPAGDYLIQFAGPFAPDDSYVDLVYAFAEFAQQQNRRHAAIQLQKRDAEI
                     YARHGFTVNQVGASYAVNLSTFTLAGSRYMQLRNKISRALRSGLTITEADYEQWQDGVR
                     NIDTRWLPLKGEGARPLEYLVGQTGGKMQKHRRLFIGHIDGEAIGYVLYSPVYGTNKGW
                     MHDLSRRLPDSPAGVMEAINKSAIDVFREEGIPWLHFGFTPFTNLSDDREVPGHSQGFK
                     WLMNYLWENQVVYPATSQLAYKQKWNQSLVLTEYAAFPGKASAEGFVNIWRAANAM"
     aSDomain        complement(10064..10954)
                     /aSDomain="LPG_synthase_C"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HYQ63_RS00550_LPG_synthase_C.1"
                     /evalue="1.00E-58"
                     /label="HYQ63_RS00550_LPG_synthase_C.1"
                     /locus_tag="HYQ63_RS00550"
                     /protein_end="317"
                     /protein_start="20"
                     /score="190.6"
                     /tool="antismash"
                     /translation="IQEHSQAENPSSFLAVNEGNSYFTLPGRPGVIVYRPAGDYLIQFA
                     GPFAPDDSYVDLVYAFAEFAQQQNRRHAAIQLQKRDAEIYARHGFTVNQVGASYAVNLS
                     TFTLAGSRYMQLRNKISRALRSGLTITEADYEQWQDGVRNIDTRWLPLKGEGARPLEYL
                     VGQTGGKMQKHRRLFIGHIDGEAIGYVLYSPVYGTNKGWMHDLSRRLPDSPAGVMEAIN
                     KSAIDVFREEGIPWLHFGFTPFTNLSDDREVPGHSQGFKWLMNYLWENQVVYPATSQLA
                     YKQKWNQSLVLTEYAA"
     gene            11370..12506
                     /locus_tag="HYQ63_RS00555"
                     /old_locus_tag="HYQ63_00555"
     CDS             11370..12506
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azoxy-crosslink: azdH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020550390.1"
                     /locus_tag="HYQ63_RS00555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00555"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_179931999.1"
                     /sec_met_domain="azdH (E-value: 8.2e-198, bitscore: 655.7,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.1e-05, bitscore:
                     23.6, seeds: 790, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSLDIAREVCERHHPGLVKALEELPLLDREAADSPVLDIFRTHG
                     GAGLLVPSAYGGVGADALEAVRVTRALGASSPSLAAAATMHNFTAAMLFALADRVVPPT
                     AEQKELLSRVAPEGMLLASGWAEGRTQQDILNPSVTATQVDDGFLLNGSKKPCSLSRSM
                     SILTASVTLPNEHGQSSLAVPLIMADSPGISVHTFWDSPVLAGSQSHEVRLKNVHVPEH
                     LIIRGTPDDPSRLDDLQEATFVWFELLITSAYVGAASTLTELVIKRERGAVTDRAALGI
                     QLEAAVGLTEGVARAIRDGLSGEEAVAAALTARFAVQKALSAINDQAVELLGGIAFIKS
                     PEIAYLSSALHPLAFHPPGRTSSSPHLVEYFNGGPLQI"
     gene            12530..13021
                     /locus_tag="HYQ63_RS00560"
                     /old_locus_tag="HYQ63_00560"
     CDS             12530..13021
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azoxy-crosslink: azdO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135862.1"
                     /locus_tag="HYQ63_RS00560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00560"
                     /product="hypothetical protein"
                     /protein_id="WP_179932000.1"
                     /sec_met_domain="azdO (E-value: 1.7e-84, bitscore: 280.4,
                     seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQLNSFESPSTTRLHRAEYLVGLGVSLVLFVWHLGEVRWFPAVF
                     LFVYIDLIGYIPGAIAYRRSADHRIHKTYYVLYNTMHSLLTQGAVVGLWIWVSGPEWAL
                     LVIPIHLCADRGVFGNFLKPFALPFEPVVNEEFARLSHALFGRPAPAVPTDPQAVDFRR
                     "
     misc_feature    12632..12634
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13018..13605
                     /locus_tag="HYQ63_RS00565"
                     /old_locus_tag="HYQ63_00565"
     CDS             13018..13605
                     /EC_number="1.5.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013756.5"
                     /locus_tag="HYQ63_RS00565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00565"
                     /product="flavin reductase family protein"
                     /protein_id="WP_179932001.1"
                     /transl_table=11
                     /translation="MTAPVTATRPTATEHDQRLQALRGISRQLPTGVAVITGAYGDAVH
                     GATVSTASVLSQQPLRLGISLRHGSYLTKLVQQRAIFVVNVLSCRQAAVADWFADPERP
                     RGLRQFDYVPWTAHEQTGIPVLDGTLAHITCRLTNVIPLGTSDDLLVAEVLEGHGRNGR
                     PLINFNGQLHDVEFRSVIRPGRRQASAVTLLE"
     gene            13649..14626
                     /locus_tag="HYQ63_RS00570"
                     /old_locus_tag="HYQ63_00570"
     CDS             13649..14626
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azoxy-crosslink: vlmB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020550387.1"
                     /locus_tag="HYQ63_RS00570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00570"
                     /product="VlmB-like protein"
                     /protein_id="WP_179932002.1"
                     /sec_met_domain="vlmB (E-value: 4.6e-171, bitscore: 567.0,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSLPPETDWDQAPGLLDGAMNLDLSAQHCDLPYWFSGVAQGTL
                     RDRAKTGHTIAETTPERMCADGPLRDAQILELGCRSVAEEQGTRVLAYYVANATSIAEM
                     DFFATQLMDEARHSMVFRNHLIEMGVPAGELHSTIAALSADYKREVLDPILGFAVRAVR
                     DEGDFIGGVAVFTIIIEGVLAPAAELSERKWSLIDPAASAIARGAAIDEIRHLTVGSSI
                     VREYLLAHPEYRPRLMDIIKRGRALWDEIPDKKYILEREHLFQEGMHQYADVIGDYEVW
                     PGQRLLETTAEERYATAEAWTDKMAAARLAYMGLDEAVEILRLT"
     gene            14695..18033
                     /locus_tag="HYQ63_RS44180"
     CDS             14695..18033
                     /GO_function="GO:0016830 - carbon-carbon lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019752 - carboxylic acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012544.5"
                     /locus_tag="HYQ63_RS44180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="WP_257231500.1"
                     /transl_table=11
                     /translation="MVGTQPSGQGESFPRTLTTSKIVFIVIAAAAPLAAMVFTVPLAFA
                     LGTGPGVPAMFAFAGLTLLCFTSGYAAISREVSGGGFYRQIAHGLGRPPAVGGGLIAVV
                     SYNAVTVGVLGAFAYFTQSVASSHGLRLHWAVWAVVGLLFVGVLGYREAELSARVLAVC
                     MVCEIAVLLALDLSVLVAHGAAALPSTSFSPNSALAPGLGVSVVFAFAAFLGFESAGLY
                     GEEAKDPGRSVPRATVVAVVVVASFYAFTSWIAVGAVGPSQVREQASRHLGDLFFGLSD
                     AYLGPVATTVMQLLLCTSLLASWLALHNAANRYMHVLSGDRVLPGWLHRVHSQHASVHR
                     ASLAQTTVSSAVVFVYTIAGLDPYVNLSTSMVGLGTLGVIVLQALASIAVLGYFRHRPR
                     HWWHTALAPALGALGLLVATVLIVRNFGVLTGTSHPVVASLPWVLVGAGVAGVVRARRM
                     RSLSPGRYARLGRGRRCAAGPRGENFGATPGGRDHCGRAQAPHNMNRAPGSLVPYRSER
                     TSPVTIRSASGPDLPFGPADTPWQKTFSGLRVVDGVPQVTAPSGDPRQLYMEIPEVPFS
                     KVQIPPNGLDERQYAEAEGLFRRYVDSQTHNFAGYQVTSDLDYQDRLSHYLDRHLNNVG
                     DPYQSSSYTLNSKALERAVLDYFASLWNAKWPHNADDPESYWGYVLTMGSSEGNLYGLW
                     NARDYLSGKLLLRQDCAGEAPSVVYTQALRRKGQSPHAYEPVAFFSQDTHYSLTKAVRV
                     LGIDTFHAIGSTRYPDQNPLGPGTPWPTEVPSVGGADGTGAIDVDKLAVLMRFFASKGY
                     PILVSLNYGSTFKGAYDDVPTVARTVREICTEYGLDERRVYHGRDRDSDFDMRSGFWIH
                     IDGALGAGYAPYLQMARDAGMVDDAPPVFDFRLPEVHSLTMSGHKWIGTPWACGVYMTR
                     TGLQMTPSRSSEYIGAADTTFAGSRNGFSALLLWDYLCRHSYDAQVRLAAECDGLAGYA
                     HDRLLALQEKLGIDLWVARSPQALTVRFRRPSDAIVRKYSLSCETIHVDGEARAYVHLY
                     AMKHLTRELVDELVRDMRQSDAFPDSEGCGARRWAGIVPALAQEDTAACRSGLLRAPVT
                     GTRSR"
     misc_feature    15121..15123
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15208..15210
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18121..18756)
                     /locus_tag="HYQ63_RS00585"
                     /old_locus_tag="HYQ63_00585"
     CDS             complement(18121..18756)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.5"
                     /locus_tag="HYQ63_RS00585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00585"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_179932003.1"
                     /transl_table=11
                     /translation="MPTKARRKRVTKSPQDRRDDILRAGERVFGTTGFEAATIAELADA
                     AEIGKGTFYLYFDSKDRLLGAMWERYVDTIVTTAQGILAEGDAWWPTIDRVMSALIRHA
                     LNNAELHRIVYGSANAKSLELCRQANQRVINLMCDFVEQGANAGAFQAVEPRLAFRMVY
                     HAADGLLDDLVALGNEAAEGKVIAMVLELAHRALGDHPYVHPEKPAVS"
     gene            18913..20121
                     /locus_tag="HYQ63_RS00590"
                     /old_locus_tag="HYQ63_00590"
     CDS             18913..20121
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643744.1"
                     /locus_tag="HYQ63_RS00590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00590"
                     /product="MFS transporter"
                     /protein_id="WP_179932004.1"
                     /transl_table=11
                     /translation="MTTERLAVPVSGTPTAGSSARFWATAYTLLFLLTGTNLPTPLYRG
                     YQQDFGFSPLVVTLIFAVYVATLIPSLLIAGPLSDSIGRRKVLLPAVVLAALGSLAFAL
                     ADNIMWLFGARLLQGLAVGAASGALTAALSELEPHGDRRRAALVSTVASVGGLGAGPLI
                     AGLLAQYAPSPRVLPFVVEILLLVPAAIAMATLPKTHTTTKWRPRRPSIPSSMRGVFVS
                     SGTASFLAFTVIGLFLSLVPTYVTKLSGSSNLALAGGAVTLMLACSVLAQIRASGKESL
                     GIQIAGLAMLAAGLVLLAVAGDISSLPLLLVATVIGGLGQGLAFLGGITEINHAAPKDR
                     HADVLSSFYVVIYLGVGVPVIGVGFLATATGLLQAVQLFAGVVAVLCLVDLAVLARKRR
                     AHA"
     misc_feature    19408..19410
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19678..19680
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20152..20628
                     /locus_tag="HYQ63_RS00595"
                     /old_locus_tag="HYQ63_00595"
     CDS             20152..20628
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYQ63_RS00595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYQ63_00595"
                     /product="hypothetical protein"
                     /protein_id="WP_179932005.1"
                     /transl_table=11
                     /translation="MDITKLASAYSELLTAAEAITPDTALVPETRADVDWRLCHIALAD
                     EIIANAARDQITGYPPVIDNQPSMDPYRITSTISATSHPQRVDSVRRNWVELQSILTIF
                     TALDADAQLKLRIHDRDGAYMNDSTMTWSALIGLRASQHIPGHRDALVQALARH"
     misc_feature    20494..20496
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20726..21547)
                     /locus_tag="HYQ63_RS00600"
                     /old_locus_tag="HYQ63_00600"
     CDS             complement(20726..21547)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="HYQ63_RS00600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00600"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_179932006.1"
                     /transl_table=11
                     /translation="MLKFRVLGTIEIQSSGYTVRPKGTLQRALLATLLVSEGHLVPTKT
                     IVDEIWGTEPPEGVENAVQAHISRLRRKLSSLEPGAGELRLVTHPRGYRLVLDDGQMDA
                     LAFTQGYDRAKDIGSPAKTASAIRPLLALWGGPVFGGPVGGMYCQAAAARYEEARLVML
                     EKLYDCELDKSQHQQIIPELRDLLVTHPYHERMHQQLMVALYRAGRQTEALQVYRELSA
                     RLADELGLLPSPTMQAYERAVLEQNPGLHLSAVVGHSVTRRPLVRQGPVQL"
     misc_feature    complement(21296..21298)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21874..21887)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.17"
                     /tool="antismash"
     misc_feature    22298..22313
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     gene            22408..22875
                     /locus_tag="HYQ63_RS00605"
                     /old_locus_tag="HYQ63_00605"
     CDS             22408..22875
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018565904.1"
                     /locus_tag="HYQ63_RS00605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00605"
                     /product="hypothetical protein"
                     /protein_id="WP_179932007.1"
                     /transl_table=11
                     /translation="MGDESARHESDRPLLRKFDQRLNELIQAIYPDERHRPGYARLAKE
                     IRDTTGGTISGTYLWELATGKKRNITLEQLDVLAQFFGVPPEYFLNEEVSELVRAQLGL
                     ATALRDIKIRNLALRAEGLSSASLDALLTMVNEARRVQELPNISPPGAENP"
     misc_feature    22729..22731
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            22999..23520
                     /locus_tag="HYQ63_RS00610"
                     /old_locus_tag="HYQ63_00610"
     CDS             22999..23520
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884649.1"
                     /locus_tag="HYQ63_RS00610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYQ63_00610"
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="WP_179932008.1"
                     /transl_table=11
                     /translation="MPYRYLRLRQRCLPLLNQIDFPRPFSAHALCRTIASQRGRQIHLH
                     PLPPEASSTGACGVLLATATADHIFYESQTSHVHQEHIVLHELGHLLFNHHRVDARYTA
                     VMGDLLPDLSDSLVTRLLGRTNYTTRQEQEAETLASLIRTSADRANRYQPRSVTGKLGA
                     ALGIETSEDE"
     misc_feature    23260..23262
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23269..23271
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23479..23481
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(24343..24356)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    24499..24517
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.57"
                     /tool="antismash"
ORIGIN
        1 gctgcccacg acccgcaggc gctggactgc cgcgcgctga cgtttgatgg cggcctcctg
       61 ggcggccagg gtctcctcca gccggcccag gacgtcctcc atgtcccggg cttcgtcgaa
      121 ggcggcccgc atgtcgtcca ggctgatgcc ggcctcggac atcttgcgga tccacagcag
      181 gcggatcatg tcgtcgtagc cgtagcggcg gcgtccgtct ccgcctcgct cgggctccgg
      241 cagcagaccg atctggtggt agtggcgaat ggcgcgcggg gtggtcccgg cgaaggcggc
      301 ggcatcaccg atcttgacct cgcggggagg cgtgacggag gggtacatcg cagacagggc
      361 ctttcgtgct gtggtgccct cgacgacacc acatgccgct acggcatatg caactacaca
      421 ccacccagat cctgacggac tatcgggcgg tccctcgcta tgggtgtccc gtaccaggac
      481 aggcccggaa tgggtgggga gatccgtcga gcaggtctga tggcaccccg agcaggggtt
      541 ggggattttc aaggagcccc atcatctcta cggatacgac cctgttgagg agggcctttg
      601 gtggaccgat cccacggcat acgactgaag ccatccagcc tcagccatta gcaccggcgt
      661 acttacgaga acttgcctcc tgcaccacac gccctctccg gtcgcaaggt ccctccgggc
      721 ttctgaatcg atgtaaggaa cagtcgccaa gcgcagaaga cgaatcagca ccttgctgcg
      781 gtggctgaag cggcgagcac cggatcgtct ttgcacgtgc ctcctggtat ccgctggtca
      841 tgtaccgtgc gctgctgagg cacttgcccc atgagcgcgg cggctttttg atggggcagc
      901 cgaggacgca gtggaggagc tcggggtcgt actggcgtgg gcaaacggcc atgaggacgg
      961 ggcggctggc gatacggatg cgggtggtga accacgacca agcgcaggac gtggggttaa
     1021 ggcggctgat gatgtaggac cagtgggggc gaggtagccg aatgcctccc ggacggctcg
     1081 cgtcgccctc gactccgggc ggcccggggc tgccgacggt tcacccctcg gtcgttccgt
     1141 ccggcttgat caggcggaag ccggtgtagc gcacgagtgc tgcggggacc tcgaccgatc
     1201 catcctggcg ctggttctgt tccagaatcg cgacgatggt cctcccgatt ggcaggccgg
     1261 acccgttcag cgtggcgacg tactccttag tcttgccgcg acgcacgcgg atgccggccc
     1321 gacgtgcctg gaagtcgccg cagtccgaga ccgacgagac ttcccggtag cagttctggc
     1381 ttggtagcca cacctcaagg tcgtaggtcc tcctggccga gaaaccgagg tcggccgccc
     1441 tcaggtcgac cacccggtag tgcaaatcga gccgttggag gcactcctcg gcatgggaaa
     1501 gcaggagctc gagttgggcc gtggcctcgc ttcgtaggca aaaccgcacg agttccacct
     1561 tcgagaattg gtggagcctg atgactcccc tggtgtcacg accgtatgat ccggcctcgg
     1621 ctcggaagca ggcggtgtgc gcggtgaggc ctagaggcaa tgcatctgcg tcaatcatct
     1681 ccctcgcgta gaggttgacg agcggtacct ctgctgtcgg gatgaggtac agggagcggc
     1741 ccgccacctg tgtggcgaac aagtcctcgg tgaatttggg cagttggccc gttcctgtca
     1801 tcgactgtgg gttcaccagg taagggacgc tgtgttcgct gtagtgatgt tccttggtgt
     1861 gtaggtcgag aaagaaggag accagggccc gctccagcgc cgctccggcg ccgcggaaca
     1921 ccgcgaatcg ggcgccggac agcttgctcg cgcgctggag atcgaggatg cctgccgagg
     1981 acgccagctc tacgtgatcg cgcggttcga agtggaaggc gggcgcccgg ccccaggact
     2041 ggacttcgac tggcgggtcc tccggccctc cgtccggcgc ctcatccgac gggacgttgg
     2101 gaatggccag tagtgcggcg tccaactgcg cttccgcagc gcgctggctc acctcggcct
     2161 cccggatgct ctccttcagg cccttggcgg cagccatatc ctccggtgtc ctggcgtcag
     2221 gccgctcggc catcgtgcgg gataccttgt tgagcgccgc acgcagggaa tcacgacggg
     2281 agatcgcttc ggcccgctgc ttggttagtt ttctcagggc ttcgaggtcg aggtaatggt
     2341 ggcgacgcct cagccgccat tccaccgaag cgtcgggcct cacaagatcc tgtagatcgt
     2401 gcactgtacc ctcctcaggt ccgtttggcc cccgctactc ggcaagagct tcttcgatca
     2461 gtccggccag tcgcgccgga tcggcttcgg ccagttgcgg ccaagccgta atgaccgtgt
     2521 ccggaccgcc gacaccgcgg aacttctcgg cgacgagttc ttggtgtcgg gcccgcaggt
     2581 cgggcccaat ggcgccccgc ggaactgagt actggcatgt gtacgagcgc ccatcgatca
     2641 tccgtgcggt cacccgcgcg ggagtcggct tcgccgtgtc ctcgaagtgg tccaacggtc
     2701 cgtcgagggg gcccacgagg tcagccagtt caggaccgcc aaagctgtgt agccacgcag
     2761 tggagagtgc gccagcctgg cgcagggcct cgccgaaggg cgcatccccg agcatcagcg
     2821 tgcgagtcat ctctgggtcg tggacgagcc gcaccttagc ggccaaggcc caccggtccg
     2881 cgccgtcgac cgcagggtgg gagaaatcct cgatcgagag cgcgcccttc agtaacgcgg
     2941 tcgccaaggg gtatggggtc gtcagaacta aagcgcccac aggggtgttc gccccgttga
     3001 ggtaaggttc cgccttccgt gccgcccaca gggtgtacat ggagcactcg acaacgacct
     3061 ccgagacatc atccaccctc cactgcccca tacggccatg caggtctgcg gcacagtcga
     3121 tggccgcgtc gatccccggc cccccagggt gcagtttgaa cgacagcgtc tcggtgtgcc
     3181 atcgcttgcc cagtcctagt gtcacggtct ctggcaaggg cacttcggcg aattgggcaa
     3241 ggaagccatc ggcatgctcc aggaggtctt cggctccgcg tagcccaccc agcgccgcgt
     3301 cacaggcgtc gagtcccatg cgtacgccaa ccggcacatg cagcaggcgt gcgtcactcg
     3361 tgaggaaacc gcgcatcaag gtccacggcg gcgcgctcag cgccagagcc agcgcttggg
     3421 cccactctgc cgcggtggcc cgctgacaag cgagccgggc ggccaccgcc cccaccacgt
     3481 gcgtgtgcaa cgccgtctgg ccgcggaacg gtccgagagt ggctgccgcc gtgattcggg
     3541 ccgcgcattc gtccgcgaga atgaccgcgc gcagcaggtc ggcccccgcc aagccgaggt
     3601 ggtacacgta agcgagcgag acacccactg tggatggccc cagatggcca gcgtacgcag
     3661 tgtcgtccag gttcagccac gctccggccc cggataggac gcgggccgat tgcgcgacgt
     3721 cttgctgtaa cggttcgccg agggccagaa cgagcctcct gccgtcctcc tgtccgaggc
     3781 cagtgcggat cgccgccaac tgagacagaa cgtggctggc tgcgaacgcg cgtacccgct
     3841 cagggacgtc gtcgagttcc agggaactcg cccaatcagc aagtgcggac agttgtgtgt
     3901 gtcgcacctc ggcggtaccg gggtgggcgg tcattgcagt cacccacccg gcctgaggtg
     3961 atgggtgaag gcggggaacc cgccaaggag aacctcaaca gtgatcgaag atagatcact
     4021 ctcgagtgcc tcaccgtcgc tctcgaagcg tagcggcagc ccgtcggtcc gttcgagcgt
     4081 cacccgacga ccacgcgcgt aagtaacacc ctcccgtccc agatggtccc ccgatcgcgt
     4141 cagatcgagc atagtcaggg gtggtacggc ggcatcgagc acgcagacat ccaggagccc
     4201 atcgtctcgt acggacctgg gcaggatgtt gtaaacgccc gcgcggtgcc gcccaccgcc
     4261 cacgttcacg agcgtcgtga ggccggagtg gacgaccctc ccatccacca cgacgcgccc
     4321 catatacggt tcgaaggtgt tcaacacccg ggatatcgct tgctgatact tgtcacggcc
     4381 cccaaccaac acggagcggg actctgcggt ggcctcagcg aagaggcccg tactcacacc
     4441 gagcacaact atcctgtcaa gaccatcgac cctggcgaga tcgagatatc tcagctcggc
     4501 accacgcagg gtcagcgccg actccagagc cgtcccccac gggacgtcgt cccacaagga
     4561 ccggtagttc gagttcccag tgccgcccgg catgacgacc agaggaatcc tgcaggcgct
     4621 tcgggccatt ccctcgacga cctcgcgaag agttccgtca ccccccacgg agacaatcat
     4681 gtcggggggc cctgcgtgcg actcgccgtc gacgagctgg gcgacaatgg cggtggcgtg
     4741 tccctggcat tcggtccacc agacatctac ggaatcagag aatatcctgc acaatgattt
     4801 catctctgca acccgatcgc gagttgtgga tcctgcggcc gggttggcaa cgatggttac
     4861 atgacggttt ctcaggggta gcgagccgtt cttgttcaag aggtccccgc gatccatgag
     4921 gagaacgaag gaagttactt ttgagcagag agggcaggat tcgtacctgc gcgggcaaga
     4981 cccgtccgag tcgacacccg gaccccgttg ggccacttcg ggtacctctc ccaaacaccg
     5041 cacgccaacc acacgcacgg gacttacgcg gagagggcag gattcgaacc tgcgcgggta
     5101 aaacccgtcc gagtcgacac ccggaccccg ttgggccact tcgggtacct ctcccaaaca
     5161 ccgcacgcca accacacgca cgggacttac gcggagaggg caggattcga acctgcgcgg
     5221 gtaaaacccg tccgagtcga cacccggacc ccgttgggcc acttcgggta cctctcccaa
     5281 acaccgcacg ccaaccacac gcacgggact tacgcggaga gggcaggatt cgaacctgcg
     5341 cgggtaaaac ccgtccgagt cgacacccgg accccgttgg gccacttcgg gtacctctcc
     5401 caaacaccgc acgccaacca cacgcacggg acttacgcgg agagggcagg attcgaacct
     5461 gcgcgggtaa aacccgtccg agtcgacacc cggaccccgt tgggccactt cgggtacctc
     5521 tcccaaacac cgcacgccaa ccacacgcac gggacttacg cggagagggc aggattcgaa
     5581 cctgcgcggg taaaacccgt ccgagtcgac acccggaccc cgttgggcca cttcggtacc
     5641 tctcccaaac accgcacgcc aaccacacgc acgggactta cgcggagagg gcaggattcg
     5701 aacctgcgcg ggtaaaaccc gtccgagtcg acacccggac cccgttgggc cacttcgggt
     5761 acctctccca aacaccgcac gccaaccaca cgcacgggac ttacgcggag agggcaggat
     5821 tcgaacctgc gcgggtaaaa cccgtccgag tcgacacccg gaccccgttg ggccacttcg
     5881 ggtacctctc cccggtgctg caccgatttc cttcgatgga gccccgttgg tgaacactct
     5941 gccacactgt gctgacaact tcctgatatc tcgctgacgg cttagacgaa ggcaccttcc
     6001 ctgtcttggc gagaagcccg ctctattcca attctccttg catcggccgc agatgaagca
     6061 catcgactca aaggctttgt gctcgccgat gcgtcagaag gagctgtgcg cgttccgcag
     6121 ggagagtcat ggcccggcga acccgctgct ggcgtcttgt tcgggaaacg caaaacagct
     6181 ccctcccagt tgaagtgcta ctactggaag ggagctggga gccgtaccag tgacatggca
     6241 agccacccgc cgcggggagg ccgctcgcgg tagccccgta gtggcggccc gggcggatga
     6301 ggagccagtg tcatggcttc tcatctatgg gtatgagtgc cttccgtgtc gcttacccag
     6361 ctcatgagct tgcgcagctc cttgccggtg gtctccagga ggtggtcctc gtccgccttc
     6421 ttcagctcgt tgtacttcgg cagaccggcg ttgtactccg ccatccagtt cttggcgaag
     6481 gtgccgtcct ggatctcgcc gaggatcttc ttcatctcgg tcttggtgga gtcgttgatg
     6541 atccgcgggc cggagacgta gtcgccccac tcggcggtct cggagatcga ccagcgcatc
     6601 ttctccaggc cgccctcgta catgaggtcc acgatcagct tcagctcgtg gaggcactcg
     6661 aagtacgcga tctccggctg gtaaccggcc tcggtcaggg tctcgaaccc ggccttgacc
     6721 agcgccgcgg tgccaccgca cagcaccgcc tgctcaccga agaggtcggt ctcggtctcc
     6781 tcggtgaagg tggtcttgat gacaccggcg cgggtgccgc cgatgccctt ggcgtacgag
     6841 agggcgagcg ggaaggcgtt gcccgtggcg tcctgctcga cggccgcgat gcacggcacg
     6901 ccgcggcctt cctcgtactg gcggcggacc aggtggcccg ggcccttggg ggcgaccatg
     6961 cagacgtcga cgttggccga cggcttgatg aagtcgtacc ggatgttgag gccgtggccg
     7021 aagaacagcg cgtcgccgtc cttcaggttg tccttcacgg actcctcgta gaccttggcc
     7081 tggatcgggt ccgggaccag gatcatgatc acgtcggcct cggcggtcgc ctccgccggg
     7141 ctcaccacgc gcaggccctg ctcctcggcc ttggccttgg acttggagcc ctcgtgcagg
     7201 ccgacgcgga cgtcgacgcc cgagtcgcgc agcgacagcg cgtgggcgtg gccctggctg
     7261 ccgtacccaa ggatcgcgac cttgcgaccc tggatgatgg acaggtcggc gtcgtcgtcg
     7321 tagaacagct cggccactgg aacgtctcct aagatgtggg gcggctggtc aagcgacgcg
     7381 cttgagaccg tgtaccgcgc tggttgtgag ggaatgcgaa ccgcggccga tcccgatcgt
     7441 gccggactgg actagctcct tgatgccaaa ctgttccagc atcttgagca tcgcctcgag
     7501 cttgtcactc gtcccagtgg cttcgatcgt gatggtctcc agagagacat ccacggtctt
     7561 ggcgcggaac agctggacga tctcgacgat ctgggagcgg gtctcgttgt ccgcgcgaac
     7621 cttcaccagc acgagctggc gctggatcga ggtaccgggc tcgagttcga caatcttcag
     7681 gacgttgacc agcttggtta tgtgcttgat gacctgctcg agtaggggtt ccttggcgtt
     7741 gaccacgatg gtgatgcggg agatgtcggg gtgctcggtg acaccttcgg cgagtgagtc
     7801 gatgttgaag ccgcggcggg agaacagggc ggcgatccgg gcgaggatgc cgggggtgtt
     7861 ctccaccagg acggagagcg tgtgcttgga catgcgatgc gtctctcttc ttctctctcg
     7921 gtcccggctc agtcgtcttc gctgtcgccg aagtccgggc gggtgtcacg cgccgccagg
     7981 atctcgtcgt tggaggtgcc ggccgcgacc atcggccaga ccatggcgtc ctcgtggacg
     8041 atgaagtcca cgaccaccgg gcggtcgttg atcgcgttgg ccttctcgat cacggcgtcg
     8101 aggtcggccg ggtcctcgca gcggatgccg atgcagccca tggcctcggc gagcttcacg
     8161 aagtccggga cccgggtgcc cgcactgggc tggccggcgt cagcaccggg gccggagtgc
     8221 agcacggtgt tggagtagcg ctggttgtag aacagggtct gccactggcg gaccatgccc
     8281 agcgcgccgt tgttgatgat cccgaccttg accgggatgt tgttcagcgc gcaggtgacc
     8341 agctcctggt tggtcatctg gaagcagccg tcaccgtcga tcgcccagac cgtacggtcc
     8401 ggcacaccgg ccttggcgcc catggcggcc gggaccgcgt accccatggt cccggcgccg
     8461 cccgagttca gccaggtcgc gggcttgtcg taggtgatga agtgggcggc ccacatctgg
     8521 tgctggccga cgcccgcggc gaagatcgtg tcctccgggg ccagctcgcc gatccgctgg
     8581 atgacctgct gcggcgacag gctgccgtcc tcgggcaggt cgtagccgag cggataggtc
     8641 tcgcgccacc ggttcaggtc ctcccaccag ccgctgtagt cgccggtgtg gcccgcgtcg
     8701 tgctcggcct ggaccgcgac gaccagatcc gcgatgacct cgcgggcgtc accgacgatc
     8761 ggcacgtcgg cggcgcggtt cttgccgatc tccgccgggt cgatgtccgc gtgcacgatc
     8821 ttggcgtacg gggcgaacga gtcgagcttg ccggtgaccc ggtcgtcgaa gcgcgtgccg
     8881 agcgccacga tcaggtccgc cttctgcagg ctggtgacgg cggcgacggt gccgtgcatg
     8941 cccggcatgc cgaggtgctg ttcgtggctg tcagggaacg cgccgagccc catcagggtg
     9001 gtggtgaccg gcgccccggt cagctcggcc agcaccctca gctcggcggt ggcgtgcgcc
     9061 ttgacgacgc cgccgcccac gtacagcacc gggcgctcgg cctgggcgat cagccgggcg
     9121 gcctcgcgga tctgcttggc gtgcggcttg gtcaccgggc ggtagccggg cagatcggtc
     9181 tgcggcggcc aggagaaggt ggtcttggcc tgcagcgcgt ccttggcgat gtcgaccagg
     9241 accgggcccg ggcggccggt ggcggcgatg tggaacgcct cggcgatcgt gcgcgggatg
     9301 tcctcggcct tggtgaccag gaagttgtgc ttggtgatcg gcatcgtgat gccacagatg
     9361 tccgcctcct ggaaggcgtc cgtaccgatg gccttggagg ccacctggcc ggtgatcgcg
     9421 acgatcggga ccgagtccat gtgggcgtcg gcgatcgggg tgaccaggtt ggtggcgccg
     9481 gggcccgagg tcgccatgca gacgccgacc ttgccggtgg cctgggcgta accggtggcg
     9541 gcgtggcccg caccctgctc gtggcggacg agtacgtgcc tgaccttcgc ggagtccatc
     9601 atcgggtcgt acgcggggag gatcgcaccg ccggggatcc cgaagacggt gtcggcgccc
     9661 acctcctcga gcgaacggat gagcgactgc gcacccgtga cgtgctcaac agcggacgac
     9721 cgttcggcgg tccggggcaa tgactgcggc gtgtggaacg ctccaggttg ttcggtcatc
     9781 ggtgttttca cgccggtgcg gatcattcgt cgacggacgc gagcagcgcg tccagttggt
     9841 gcagcgcctc gtctgccccc tgggcggccg cactatcgtc ggggtctgcg cacagctgga
     9901 cgaagaaggc ggccagtcgc tgctgggcgt cgtcgaggac ttcggtgggg ttctgcagtg
     9961 tcgtcatggt cgtgccttcc ttgggacggg tccggtgtcg tcacatggca ttcgcggcac
    10021 gccagatgtt cacgaacccc tcggcgctag cttttcccgg gaatgccgca tactcggtga
    10081 gaacgagact ttggttccat ttctgcttgt aggcaagctg tgaggtagcg ggatatacca
    10141 cctggttctc ccacaagtag ttcatgagcc atttgaatcc ctggctgtgg ccgggtactt
    10201 cgcggtcgtc gctgaggttg gtgaacgggg tgaatccgaa atgcagccag gggattccct
    10261 cttcgcgaaa cacgtcgatg gcggatttgt tgattgcttc catgacgcct gcgggactgt
    10321 cagggaggcg acgactcagg tcatgcatcc agcccttgtt ggtgccatac accggcgaat
    10381 acaggacata gccgatggct tcgccgtcga tgtgcccgat gaacagtcgg cggtgcttct
    10441 gcatctttcc gccagtctgg cccacgaggt actcgagagg gcgagcccct tcccccttga
    10501 gcggcagcca ccgagtgtcg atgttccgga cgccgtcctg ccactgttcg tagtccgcct
    10561 cggtgatcgt caagccgctg cgcagtgccc gtgagatctt gttacgcagc tgcatgtaac
    10621 gcgatcctgc cagcgtgaag gtgctcaggt tcacggcgta ggaggcgccg acctggttca
    10681 ccgtgaaccc gtggcgcgcg taaatctcgg cgtcccgttt ctgcaactgg attgcggcgt
    10741 gcctgcggtt ttgctgctgg gcgaactcgg cgaaggcgta gacgaggtcg acgtaggagt
    10801 cgtcgggggc gaatgggcca gcgaactgga tcaggtagtc gcccgctggt cggtacacga
    10861 tgacgcccgg gcggcccggg agcgtgaagt aggagttccc ctcgttgacg gcgaggaagg
    10921 aactggggtt ctccgcctga ctgtgttcct gtatggcact gagcacatat tccgcagagg
    10981 cctgcgagtc cgtctccagg gtttgactgc ccataccagg aggctccttc cttgtcatct
    11041 ctcttgcgct tcccgctctt cgacctagct tcgttttcta ggccgaggcg cacatcagag
    11101 cacatggtgc tccatcgccc cgatgcaagc aataccatat ctgtgaaatc tggcgacctg
    11161 tcagccactt atcacttacc tgtcagctaa aagcgcatga catgcgagaa cccatgacgt
    11221 cagggtgatg tcagcagagc gtgcgatgct tgttccggta aagccggata ccccatgccg
    11281 gcttccggat agttcttcca ggcttctgaa tgctgttctg cgtcgggagc tatccgtctc
    11341 tccgatgggt ttccggaggt taaccccaca tgcgttctct cgatattgcc cgcgaggttt
    11401 gcgagcgcca ccaccccggg ttggtcaagg cgctcgagga actgccgctg ctggaccggg
    11461 aggcggctga cagccctgtc ctggacatct tccggacgca cggcggtgca ggactgctgg
    11521 tgccgtctgc gtatggtgga gtcggtgccg acgcgctcga ggcggttcgg gtaaccaggg
    11581 cactgggagc ctcctcgccc tcactcgcgg cggccgcgac catgcacaac ttcacggcag
    11641 cgatgctttt cgcactcgcc gaccgggtgg tgccgccgac agcggagcag aaggagttgc
    11701 tgtcgcgcgt ggcgccggag gggatgctgc tggcctccgg gtgggccgaa ggccgcaccc
    11761 agcaggacat cctcaacccg tcggtgacgg ctacgcaggt cgatgacggc ttcttgctca
    11821 acggctcgaa gaagccatgc agcctgtcgc gttcgatgag catcctgacg gcgagcgtca
    11881 cgctgcccaa cgagcacggt cagtcctccc ttgccgtacc gctgatcatg gctgactccc
    11941 cggggatctc cgtgcatacc ttctgggaca gcccagtact agcgggctca cagagccatg
    12001 aggtgcgtct gaaaaacgtg cacgtgcctg agcacctgat cattcggggt accccggacg
    12061 accccagtcg gctagacgac ctccaagagg cgaccttcgt ctggttcgag ctgctgatca
    12121 cctcggcgta cgtgggggcc gcgagcaccc tgacggagct ggtcataaag cgcgagcgtg
    12181 gcgctgtgac tgaccgtgcc gcgctcggta ttcagttgga ggcggccgtt ggactgactg
    12241 agggagtggc ccgggccata cgagacggcc tttctggcga ggaggccgtc gcggcggccc
    12301 tgacagcccg gttcgccgtg cagaaggccc tctccgcgat caatgaccag gccgtcgaac
    12361 tgctcggcgg aatcgcgttc atcaagtcgc ctgagatcgc ctacctatcg tcggccctgc
    12421 acccgctcgc cttccacccg ccgggccgca ccagctcctc gccccacctg gtcgagtact
    12481 tcaacggcgg ccccctgcag atctgacccg cgcgggaggc ggatcaccca tggatcagct
    12541 caactctttc gagtcaccgt caacgacgcg tctgcatcgt gcggagtacc tggtggggct
    12601 tggggtctcg ctggtgctgt tcgtctggca cttaggcgag gtccgctggt tcccggcggt
    12661 cttcctgttc gtctacatcg acctgatcgg atacataccc ggagccatcg cctaccgcag
    12721 gagtgccgac catcgcatcc acaagacgta ttacgtcttg tacaacacca tgcacagcct
    12781 gctaacccag ggggcagtgg tggggctgtg gatctgggtg agcgggccgg aatgggcgct
    12841 actcgtcatc ccgatccatc tgtgcgccga ccgcggggtg ttcggaaact tcctcaagcc
    12901 attcgcgctc cccttcgagc cggtcgtcaa cgaggagttc gctcggctgt cacacgcgct
    12961 gttcggcagg ccggcacccg cagtgccgac tgatccgcag gccgtggact tccggcggtg
    13021 accgccccgg tgaccgcgac ccgcccgacc gcaaccgagc atgatcagcg tctacaggct
    13081 ctacggggca tctcgcgcca actgcccacc ggggtggccg tcatcacggg cgcgtacggc
    13141 gacgccgtgc acggggccac cgtcagcacc gcaagcgtgc tgtcccagca gccgttgcgg
    13201 ctaggtatca gtcttcgcca cggctcatac ctgaccaaat tggtgcagca acgggccata
    13261 ttcgtcgtga acgtgctgtc gtgccgccaa gcggccgtgg cggactggtt cgccgaccca
    13321 gaacgccccc ggggactacg gcagttcgat tatgtgccgt ggacagccca cgaacagacc
    13381 ggcattccgg tgctcgatgg caccctcgcc cacattacct gtcggctgac caacgtgatc
    13441 ccgctgggga ccagtgacga cctgctcgtc gcggaggtcc tggaagggca cggccggaac
    13501 ggccgtccac tgatcaactt caacggccag ctccatgacg tggaattccg gagcgttatc
    13561 cggcccggtc gcaggcaggc cagcgccgtc acgctactcg agtagcaact gccccatacg
    13621 cacttacgcg aaaggaaatc acgacatcat gacgctttcc ctccctcccg agacggactg
    13681 ggatcaggca ccggggctgc tcgacggggc gatgaacctg gacctgtcgg cccagcactg
    13741 cgacctgccg tactggttca gcggtgtcgc gcaggggacg ctgcgcgacc gtgccaagac
    13801 cgggcacacc atcgcggaga ccaccccaga gcgcatgtgc gccgacggcc cgctgcgtga
    13861 cgctcagata ctggagcttg gctgccggtc agtggccgag gagcagggga ccagggtgct
    13921 tgcatactac gtggccaacg ccaccagcat cgcagagatg gacttcttcg cgacccagct
    13981 gatggacgag gctcggcact cgatggtctt ccgcaaccat ctcatcgaga tgggcgtccc
    14041 ggccggggag ttgcactcca cgatcgccgc gctatcggcc gactacaagc gggaagtgct
    14101 cgacccgatc ctcgggttcg ccgtgcgcgc ggtgcgtgac gagggcgact tcatcggcgg
    14161 cgtggcggta ttcaccatca tcattgaggg ggtgctggcc cccgcagccg agctgagcga
    14221 gcgcaagtgg agcctgatcg accccgcagc cagcgccatc gcccgcggcg cagcgatcga
    14281 cgaaatccga cacctgacag tgggcagttc gatcgtgcgc gagtacctgc tggcgcaccc
    14341 tgagtaccgg ccgcggctga tggacatcat caagcgcggc cgcgcgctgt gggacgagat
    14401 ccccgacaag aagtacatcc tcgagcgcga gcacctgttt caagagggca tgcaccagta
    14461 cgccgacgtc atcggcgact acgaagtgtg gcccggacaa cggctgctgg aaaccacggc
    14521 tgaagagcgg tacgcgaccg ccgaggcatg gacagacaag atggccgccg ctcggctcgc
    14581 ctatatgggg ctggacgagg cggtggagat cctccgtctg acctgacccg gcctgcggcg
    14641 gcgggcccct ccgccgccgc gttcctctct tccccgtttc ccgcaggaga ctctgtggtc
    14701 ggcacgcaac caagtgggca gggcgagagt tttccgcgca ccctcaccac ttccaagatc
    14761 gtgttcatcg tcatcgcagc agccgctccg ctggccgcga tggtcttcac cgttccgctc
    14821 gccttcgccc tgggcaccgg gccaggcgtg cccgcgatgt tcgccttcgc tgggctgacg
    14881 ctgctgtgct tcacctccgg ttacgccgcg atcagccgcg aggtcagtgg cggcggcttc
    14941 tacagacaga tcgcccacgg cctggggcgt ccgcccgctg tgggcggcgg cctgatcgcc
    15001 gtggtctcct acaacgccgt cacggtcggc gtcctcggcg ccttcgccta cttcacccaa
    15061 tccgtggcat ccagtcatgg gctgcgtctg cactgggccg tgtgggctgt agtcggcctg
    15121 ttattcgtcg gggtgctggg ctaccgcgaa gccgagctga gcgcgcgggt gctggcggtg
    15181 tgcatggtgt gcgagatcgc cgtcctctta gccttggacc tgtccgtcct ggtcgcccac
    15241 ggtgccgccg ccttgcccag cacgtcgttc tcgccgaact ccgctctcgc ccccggcttg
    15301 ggggtgtctg ttgtgtttgc gttcgccgcc ttcctcggct tcgaatcggc aggcctctat
    15361 ggggaggagg cgaaggaccc aggccgcagc gtgccgcgtg cgacggtcgt cgccgttgtg
    15421 gtggtcgcat cgttttacgc cttcaccagc tggatcgcgg tcggtgccgt cggcccgtcg
    15481 caggtgcggg agcaggcgtc ccggcatttg ggggacctgt tcttcggtct cagtgacgcc
    15541 tacctcgggc cggtcgcgac caccgtcatg caactgctgc tgtgcaccag tctgctggcc
    15601 agttggctgg ccctccacaa cgcggcgaac cggtacatgc acgtgttgag cggtgatcgg
    15661 gttctgcctg gctggctgca ccgcgtccac tcacagcacg cctccgtgca ccgggcgagc
    15721 ctggctcaga ccactgtgag ttcggcggtc gtcttcgtct acaccatcgc tggcctggat
    15781 ccgtacgtga acttgtcgac cagcatggtc ggcctaggta cgctcggcgt gatcgtgctc
    15841 caggccctcg cgtcgatcgc cgtgctgggt tacttccggc accgtccacg gcactggtgg
    15901 cacactgccc tggccccggc gctgggggcc ctggggttgc tggttgcgac cgtgctaatc
    15961 gtgcggaact tcggggtgct gacaggaacg tcccaccctg tggtcgcctc cctgccctgg
    16021 gtcctagtgg gcgctggagt tgccggtgtg gtccgggccc ggcgcatgcg ctccctctcc
    16081 cccgggcgtt acgcccgact cggccggggg cgccgctgcg ccgccggtcc taggggcgag
    16141 aacttcggtg caacccctgg aggccgggac cactgcggga gggctcaagc cccccacaac
    16201 atgaaccgcg ccccaggctc actcgtccct taccgcagcg aaaggacctc ccccgtgacg
    16261 atccgctccg cctccgggcc ggacctgccc ttcgggcccg cggacacccc gtggcagaag
    16321 acgttcagcg gtctgcgagt ggtggatggc gtgccccaag tcaccgctcc gtccggcgac
    16381 cctcgccagc tctacatgga gatacccgaa gttcccttct caaaggttca aattccgccg
    16441 aacgggctgg acgaacggca gtatgcggag gccgagggcc tcttccgccg ctacgtggac
    16501 agccagaccc acaacttcgc tggataccag gtcaccagcg acctcgacta ccaagaccgc
    16561 ctcagccact atctcgaccg ccacctcaac aatgtcggcg acccctatca atccagttcc
    16621 tacacgctga actcgaaggc cttggaacgg gccgtactcg actacttcgc ttccctctgg
    16681 aacgctaagt ggcctcacaa cgcggacgac ccggagtcgt actggggcta cgtgctgacc
    16741 atggggtcca gcgagggcaa tctatatggg ttgtggaacg cgcgtgatta cctgtcaggc
    16801 aagctgctgt tgcgacagga ttgcgctggc gaggcgccct cagtggtgta cacgcaagcg
    16861 ctgcggcgca agggacagag cccgcacgcc tacgagccgg tggcgttctt ctcacaggac
    16921 acccactact cgctgaccaa ggccgtgcga gtgctgggca ttgacacctt ccacgccatc
    16981 ggcagcacac ggtacccaga ccagaacccg ctggggccgg gcaccccctg gccgaccgaa
    17041 gtgccctccg tcgggggggc cgacggcacc ggcgccattg atgtggacaa gctcgccgtc
    17101 ctgatgcggt tcttcgccag caagggctat cccatcttgg tcagcctcaa ctacgggtcg
    17161 acgttcaaag gggcctacga tgacgtgccc accgtggccc ggaccgtccg ggagatctgc
    17221 acggaatacg gcttggatga gcggcgggta taccacggcc gtgaccggga cagcgacttc
    17281 gacatgcgca gcgggttctg gatccacatc gacggcgcgc tcggcgcggg ctacgcaccc
    17341 tacctgcaga tggcccggga cgctgggatg gtcgacgatg cgccgccggt tttcgacttc
    17401 cggctgcccg aggtgcattc gctaaccatg agcggtcaca agtggattgg cacgccgtgg
    17461 gcgtgtggag tgtacatgac ccggacaggg ctgcagatga ccccatcgag gtcgtcggag
    17521 tacatcgggg cggccgacac cacgttcgct gggtcgcgta acggcttctc ggccctgctc
    17581 ctgtgggact acctgtgccg gcattcgtac gacgcccagg tgcggctggc cgccgagtgc
    17641 gacggactgg cgggctacgc gcacgaccgg ctgctggccc tccaagaaaa gctgggcatc
    17701 gacctgtggg tggcgcgtag cccgcaggcc ctgacggtcc ggttccgccg gcccagtgat
    17761 gcaatcgtcc gcaagtactc gctgtcctgt gaaaccatcc atgtggatgg ggaggcccgg
    17821 gcctacgtac acctatacgc gatgaagcac ctcacgcggg agctggtgga tgaactggtg
    17881 cgggacatgc gccagtcgga cgccttcccc gactccgagg gctgcggggc gcgccggtgg
    17941 gcagggatcg tccctgcctt ggcgcaggag gacaccgcag cctgccgctc cggactgctg
    18001 cgagctccgg tgacgggaac ccgcagtcgc tgatacgggt ggttccgtga ccggttgggg
    18061 cgagggcaag atgtcctcgc cctgtcgcgt gtgctcgacg ggggggtgcg cagggcggtc
    18121 tcaagaaacg gcaggcttct ccgggtggac gtaaggatgg tcccccaggg cccggtgggc
    18181 cagttcgagc accatggcga tgaccttgcc ctcggcggcc tcattgccca gggcgacgag
    18241 gtcgtcgagc aggccgtcgg cggcgtggta caccatgcgg aatgccaagc ggggctcgac
    18301 ggcctggaag gcgccggcgt tcgcgccctg ctcaacgaag tcgcacatca ggttgatcac
    18361 gcgctggttg gcctggcggc acaattcaag ggacttggca ttggccgagc cgtacacaat
    18421 gcggtgcagt tcagcgttgt tcagggcgtg cctgatcagc gcgctcatta cacggtcgat
    18481 ggtgggccac caggcgtcgc cctcagccag gatgccctgg gccgtggtga cgatggtgtc
    18541 gacgtagcgc tcccacatcg ccccgagtag gcggtccttc gagtcgaagt acaagtagaa
    18601 ggtgcccttg ccgatttcgg ccgcatccgc gagttcggcg atggtggctg cttcgaagcc
    18661 ggtagtgccg aacacccgct cccctgcgcg cagtatgtcg tccctgcggt cctgagggct
    18721 ctttgtgacc cgcttccttc gcgcctttgt cggcatgccc acctccctgc ggatactgcg
    18781 tggccttcca gcatatctga ccggtggtcg gtcactggca ttgactgacc accggtcatt
    18841 tgcttgactg accggcagtc actggctgcg gtgccctggc ccacagcccc tacgacgaag
    18901 cttgaggacg agatgacaac ggaacgactg gcggttcccg tcagcggcac gcccaccgcg
    18961 ggcagctctg cccgattctg ggccaccgcc tacaccttgc tgtttctgct gacgggcaca
    19021 aaccttccca cccccctgta ccgcggatac cagcaggact tcgggttctc acccctcgtg
    19081 gtgaccttga tcttcgcggt gtacgtggcg accctgatcc cttccctgct tatcgccggg
    19141 ccgctgtcag actcaatcgg gcgccgcaag gtcctgctgc ccgccgtagt tctggctgct
    19201 ctgggatcac tggccttcgc gctcgcagac aacatcatgt ggcttttcgg agcccgccta
    19261 ctccagggac tggccgtggg cgccgcctcc ggtgccctca ctgcggcact cagcgaactc
    19321 gaaccccatg gcgaccggcg gcgggccgcg ctggtgtcca ccgtcgcctc ggtcggcggc
    19381 ctgggcgccg gccctctgat tgcggggtta ctcgcccagt acgctccgtc cccgcgcgtg
    19441 ttgccgttcg tcgtggagat cctgctacta gtccccgcgg ccatcgcgat ggccactctg
    19501 cctaagacgc acaccaccac gaagtggcgc ccccggcggc cctccatccc gtcctccatg
    19561 cgcggcgtct tcgtctcgag cggtacggcc agtttcctgg cgttcaccgt gatcggtctc
    19621 ttcctcagcc tcgtgccgac ctatgtcacc aaactatccg gcagcagcaa ccttgcctta
    19681 gccggtggcg ccgtgacgct gatgctcgcc tgctcggtac tcgcgcagat ccgtgcatcg
    19741 ggcaaggagt cgcttggtat ccagatcgct ggcttggcca tgctggccgc cggcttggta
    19801 ctgctggctg tcgcgggcga catctcatca ctgccgctgc tgttggtagc gaccgtcatc
    19861 ggcggcctgg ggcagggact cgccttcctg ggcggcatca cggagatcaa ccacgccgca
    19921 cccaaggacc ggcacgccga cgtactgtcc agcttctatg tcgtcatcta tctcggggtt
    19981 ggcgtccctg tcatcggggt tgggttcctc gccaccgcca ccggtctgct ccaggccgtc
    20041 cagctattcg ccggcgttgt cgccgtgctg tgcctggtgg acctggccgt gctagcccgc
    20101 aagcgccgcg cacacgcctg agcgctcccc ctcctcacta cggaagaact catggacatc
    20161 accaagctcg cctcggccta cagcgaactg ctcacggccg ccgaagccat cacccctgac
    20221 actgccctcg tccccgagac ccgcgccgat gtcgactggc ggctatgcca cattgctcta
    20281 gcagacgaga tcatcgcaaa cgccgcccga gatcaaatca ccggctaccc ccctgtcatc
    20341 gacaaccagc cgtcgatgga cccctatcgg atcacttcga cgatcagcgc tacctcccac
    20401 ccacagcgcg tagacagcgt ccgccgcaac tgggtcgagc tccaaagcat tcttacaatt
    20461 ttcaccgcac tggacgccga cgcccagctc aagttacgca tacacgaccg cgacggggca
    20521 tatatgaacg actcgaccat gacatggtcg gccctgatcg gactgcgcgc cagccagcac
    20581 atccccggcc accgcgacgc gcttgtccag gctctagccc ggcactgatc gcacacccgc
    20641 actgcggtgg attcctctcc ccctggtgtc agtagggaag gggcccgccg catgtcctcc
    20701 cggcacacgg cggccccggc gccagtcaaa gctggaccgg cccctgccgg acgagggggc
    20761 gccgtgtgac ggagtggccg acaacagcgc tcaggtgcag gcctggattc tgctcgagca
    20821 ccgcccgctc gtaggcctgc atcgtgggcg agggcagcag cccaagttca tccgccagcc
    20881 tcgcgctcag ctcgcggtag acctgaaggg cctcggtctg acgaccggct cggtagagag
    20941 caaccatcag ctgctggtgc atccgctcat ggtatggatg cgtgaccagc aagtctcgca
    21001 actccgggat gatctgttga tgctgggact tgtcaagctc gcagtcatac agtttctcca
    21061 gcatcaccag ccgggcttcc tcgtagcgcg ccgcggccgc ctggcagtac atccctccga
    21121 ccggcccccc gaaaacgggt ccgccccata gcgccagcag agggcggatg gccgatgcgg
    21181 tcttggccgg tgagccgata tccttggcgc ggtcgtaacc ttgcgtgaaa gccagggcgt
    21241 ccatctggcc gtcatcgagc acgaggcggt agccgcgggg gtgggtcacc agccgtaact
    21301 cgccggcgcc cggttccagg gatgacagct tcctgcgaag gcgactgatg tgcgcttgga
    21361 cggcgttctc cacgccctct gggggctcag tgccccagat ctcatcgaca atggtcttcg
    21421 tgggcacgag gtgcccttcg ctgaccagga gcgtagccag cagtgcacgt tgtagcgtgc
    21481 ccttggggcg gactgtgtag cccgaggact gaatttcgat cgtgccaagt acccgaaact
    21541 tcagcatcgc tgctccagtg gaagaggccg tggggtgccc ctcgtactgc ggcatggggg
    21601 cccgcgggga gtgggtcagg gtgttgtgct tgagaacgcc cgccggacgc ggaccggaag
    21661 ttgggggtcc gtccacagtc ccgcaggtac cgaaagacaa cgggcgtctg cataactgtg
    21721 ggtccccccc gtttgacgcc tccgcgcagc actacgtccg cagccagcct caggggccga
    21781 caaccggccg gacgtgccgc cagcagttca ctgaatgacc gactgtcggt cattcagacc
    21841 ctttcatgtc gcaaccatca ggtcaacgac tggtcacgga aggtgaccta ggtgggcgac
    21901 taactttgcc gaacgcgggt caccgcaaga cacccgaccc gagcaacctg cggataccgg
    21961 acggcatgcc gaagtccgcc agtaagcatt gacgcccgcg acggaccgca tcgcattacc
    22021 gcgtcaataa ctggcataca gtcgaggttc aaaaatgccc cctgagatgc gcaaccctgg
    22081 atccagcacg tgcgtcgctt gccaaatcga ccgagatgga agctgccgag gaactcggag
    22141 gccagtttcc tgatccggga ccgaagttac tcagacatgt ggaatgaacg ccgacccgtg
    22201 atacaccagg acactaatgg ggcggacgat tgagcgtcaa cccgtccgct agaacggatg
    22261 acagatgact gagatgcttc ggcgctggcc tgtccgagat cacacttgtc agctatggcg
    22321 tacacagata cagatggatg gatgcatgca ccgatcgttc gcgcctgggt tgtcgtgcct
    22381 ggtcgcaaac tgagcgaggg atgagctatg ggcgacgaat cggcacgtca tgaatcagac
    22441 cgtccactgc tgcggaagtt cgaccagcgg ctcaacgaac tgattcaagc catctacccc
    22501 gatgagcggc acaggcccgg ctatgcccga ttggccaaag agattcgcga caccacaggt
    22561 gggacgatct ctgggactta cctttgggag ctggccacag gtaagaagcg caacatcacg
    22621 ctggaacagc tcgacgtcct cgcccagttc ttcggtgtcc ctccggagta cttcctgaac
    22681 gaggaggttt cggaactcgt cagagcgcaa cttggacttg cgacagcttt acgtgatatc
    22741 aaaattcgca atttggcatt gcgagccgag ggcctatcct cagccagtct ggacgccctg
    22801 ctgacgatgg tgaacgaggc acgcagggtt caggaactac ccaacataag tcctcccggg
    22861 gcggagaacc cgtaagcaaa catttgacaa cctgcagctt ttctccaatc gcgtgaaagt
    22921 cgactggaga tggaagttac cgtgtccatc tgcgtgaccg cctatcgacg ttgcccggga
    22981 aggggtgggg agggatccat gccgtaccga tacctcaggc tgcgtcagcg atgtctgcct
    23041 ttgcttaacc agatcgactt cccacgaccg ttctcggccc acgccctgtg ccgaaccatc
    23101 gccagccaac gggggaggca gattcatctt caccccctgc cgccggaagc ttcgtcgacc
    23161 ggcgcctgcg gggtgttgct ggccaccgcc accgccgacc acatcttcta cgaaagccag
    23221 acgtcgcatg tgcatcagga gcacatagtg ctccacgaat taggccactt actcttcaac
    23281 catcacagag ttgacgctag atacacagcc gtgatgggcg accttctgcc cgatctgagc
    23341 gacagcctag tgacccgtct cctcggacgc accaactaca ccacgcgcca ggagcaggaa
    23401 gcagaaacgc tcgcgagcct gatacggacg agcgcggacc gagcaaaccg ttaccagccg
    23461 cgcagcgtga ctggcaagtt aggagccgcc ctggggatag agacatcaga agatgaatga
    23521 cctggacgag ctcgggcgat cgcttacata ccccagcgtc attatcctct ggtccgctgc
    23581 ccttatacgt ctcccagggg ctgctcgctc gccgcatcaa cgtgggttgt ggctggctgt
    23641 ggtcaccgca gctatggcca tggcgctgaa tgcaccggcc ggacacacac tgacgtccta
    23701 tctcggccca gcccaccgca tttccctggc caaaaacatg ttcggagtcc tgtcagccgg
    23761 cgccgtgctc tacttcgttg cctcctccgc tggcggccgt cgtctccgct caaccttatg
    23821 catagcgttg ggcatcacgc tgggggtgct tcccgtgctc gacctgctgg cctcccggca
    23881 cggagagcac aatattcctc ctgccgctgg cgacccggtc ttctcctacc cgttctggtt
    23941 aatcttgatg gtggctcacc ttgttgccaa cttcacctgc gcgtctgtct gcatgcggta
    24001 cggctggcgc gcgagcactc gctcggtcag agtcagcttg catctgttcg ggatcggtac
    24061 ggcactcgct ggagtgtact ggctggactt cttgcttcgg ctcacggcag gcatcggttg
    24121 gcccacggcg gtcatgcccc tattgatgaa tctgcacggc ctgttcagag cagcggccat
    24181 cttggtgccg tccgtcgtta ctattggccg gaagaccgcc acgatagtga ccacgtggcg
    24241 tctgtggcca ctctggcgcg aactggtgga tgctgtcccg cacgtggttc tggctaggcc
    24301 tcagaagagg ctgctcgaga ccctctggcc ggccgtcccg cgcgaacttt tgctttaccg
    24361 caaagtaata gagactcggg acgccatcct cgtcctcaac agctacgtgg ccgccggtac
    24421 gtgggatcac gcgcgctgtc acgtggccga ggctcatgtc tcccagacca aggccgaggc
    24481 aacgacgctt gcgtgcgtgt tgagaagagc ccgcaacgac aagctcgccg gcataccgcc
    24541 gcaaccgccc gttgacggtt ccggaagctt cgacaacggc gaccttgata gcgagaagac
    24601 attcctcctc gacgtggcgc aagcct
//
