LOCUS       NZ_CP040752            10384 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces rectiverticillatus strain B15-08 chromosome, complete
            genome.
ACCESSION   NZ_CP040752
VERSION     NZ_CP040752.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces rectiverticillatus
  ORGANISM  Streptomyces rectiverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7679243)
  AUTHORS   Park,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAY-2019) Laboratory of Bioorganic Chemistry, NIDDK,
            NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: DEC-2018
            Assembly Method                   :: HGAP v. Dec-2018
            Assembly Name                     :: DDK_LBC_B15-08
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013394065.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:49:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,642
            CDSs (total)                      :: 6,543
            Genes (coding)                    :: 6,394
            CDSs (with protein)               :: 6,394
            Genes (RNA)                       :: 99
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 55 of 149
            Pseudo Genes (incomplete)         :: 125 of 149
            Pseudo Genes (internal stop)      :: 12 of 149
            Pseudo Genes (multiple problems)  :: 41 of 149
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:46:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5125164
            Orig. end                         :: 5135548
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040752.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from LBC, NIDDK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10384
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="26"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10384
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10384
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5384](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5384
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(1217..3325)
                     /gene="pta"
                     /locus_tag="FGW37_RS22590"
                     /old_locus_tag="FGW37_22840"
     CDS             complement(1217..3325)
                     /EC_number="2.3.1.8"
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pta"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714959.1"
                     /locus_tag="FGW37_RS22590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_22840"
                     /product="phosphate acetyltransferase"
                     /protein_id="WP_179082714.1"
                     /transl_table=11
                     /translation="MTRSVYVTGTDRGDGRQVIELGVMELLTRQVDRVGVFRPLVHGDG
                     PDRLFDLLRSRYRLGQSAESGHGMSYAEASALQAERGTDELVSRLVERFHAVARDYEYV
                     LVLGTDYVGSTLPDELALNARLANEFGASVITVVGGQDQTAESVRSEARNAYRAYEALG
                     CDVVALVVNRVAPADREAVAERLSASLPVPCYALPEEAGLSAPTVAQIVRKLNAEVLLG
                     DDAGLARDAKDFVFGGAMLPVFLPALTEGCLVVTPGDRVDLIVGALAAHSAGAPPIAGV
                     LLTLDEKPGPDILALADRLAPGTPVVSVPGGSFPTAAELFAIEGKLDAFSPRKAETALG
                     LFERHVDTAELTNRIAVARSSRVTPMMFEHELIERSRSARRRIVLPEGTEERVLRAADV
                     VLRRDICDLTLLGEEGAIRKRAGELGIDLAAAQIIDPQTSPLRERFAEIYAKARAHKGM
                     TVELAHDVVTDVSYFGTLMVQEGLADGMVSGAVHSTAATIRPAFEIIKTAPGAQIVSSV
                     FFMCLADRVLVYGDCAVNPDPNAEQLADIAIQSAATAAQFGVEPRIAMLSYSTGTSGSG
                     ADVDKVRKATEIVRERRPDLKVEGPIQYDAAVDAAVAKTKLPGSEVAGKATVLIFPDLN
                     TGNNTYKAVQRSAGAVAVGPVLQGLRKPVNDLSRGALVQDIVTTVAISAIQAQGETGNG
                     TAPHAPAV"
     misc_feature    complement(3385..3394)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.77"
                     /tool="antismash"
     gene            3610..4635
                     /locus_tag="FGW37_RS22595"
                     /old_locus_tag="FGW37_22845"
     CDS             3610..4635
                     /EC_number="2.7.1.11"
                     /GO_function="GO:0003872 - 6-phosphofructokinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983263.1"
                     /locus_tag="FGW37_RS22595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_22845"
                     /product="ATP-dependent 6-phosphofructokinase"
                     /protein_id="WP_179082715.1"
                     /transl_table=11
                     /translation="MRIGVLTAGGDCPGLNAVIRSVVHRAVAGHGDEVIGFEDGFKGLL
                     DGRHRKLDLEAVSGILARGGTILGSSRLERARLREACESSKELAREYGIDVLIPIGGEG
                     TLTAARMLSDAGLPVVGVPKTIDNDISSTDRTFGFDTAVGVATEAIDRLKTTAESHQRV
                     MVVEVMGRHAGWIALESGMAGGAHGICLPERAFEVDDLVKMVEERFARGKKFAVICVAE
                     GAHPAEGSMEYAKGAIDQFGHERFAGIGTKLAAELEKRLGKEARPVILGHVQRGGTPTA
                     YDRVLATRFGWHAVEAAHRGDFGKMTALKGTDIKMVPIADAVTELKRVPESRMDEAESV
                     F"
     misc_feature    complement(4772..4792)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.67"
                     /tool="antismash"
     misc_feature    4893..4907
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.49"
                     /tool="antismash"
     misc_feature    4955..4970
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.18"
                     /tool="antismash"
     misc_feature    complement(4972..4986)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     misc_feature    complement(4973..4986)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.57"
                     /tool="antismash"
     gene            5001..5384
                     /locus_tag="FGW37_RS22600"
                     /old_locus_tag="FGW37_22850"
     CDS             5001..5384
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662974.1"
                     /locus_tag="FGW37_RS22600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_22850"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_179082716.1"
                     /sec_met_domain="melC (E-value: 7e-35, bitscore: 118.8,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLTRRRMLGRTAAAAAGIVLAGPAAQAFAAESGHDHHGNGNGN
                     GNGSGHRPFDEIYEGRRIEGRLTSGTGGHHDFGIAVFVDGRPLHIMPRGNGWISVMNHY
                     EVFASPYEVTRAAVRALRGVNLV"
     gene            5422..6282
                     /locus_tag="FGW37_RS22605"
                     /old_locus_tag="FGW37_22855"
     CDS             5422..6282
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267950.1"
                     /locus_tag="FGW37_RS22605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_22855"
                     /product="tyrosinase family protein"
                     /protein_id="WP_179082717.1"
                     /transl_table=11
                     /translation="MAVRKNQAKLTKAERRDFVEALLELKRRGGYDKYVEIHDRFVMSD
                     LDDQERTGHVSPSFLPWHRQFLLDFERDLQSVNPAVTLPYWDFTVNRSLSDPIFAPDFL
                     GGNGRERDAQVMDGPFAYSGGRWPIYFKADERPFLMREMGRSATTPQLPTAATVEAALA
                     APYYDEAPWNSTSKAGFRNLVEGWANGNTGPHNTVHRWVGGHMNTGMSPNDPVFWLLHC
                     FIDKLWSDWQRRHPKAPAYLPVEPVKDIVALNEPMKPWSEKGQRVTPADMIDHRKFYAY
                     DTDAA"
     gene            6825..7823
                     /locus_tag="FGW37_RS22610"
                     /old_locus_tag="FGW37_22860"
     CDS             6825..7823
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016473122.1"
                     /locus_tag="FGW37_RS22610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_22860"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_246430508.1"
                     /transl_table=11
                     /translation="MTEPGVGPEAPGNMRTLVLSNDLDETREIISSAYSPYQLSVLGDP
                     KEFSAWYAEGGFPGITVSGLQYGAETLVAPQPLDSYLLVCQLVRGRVRVMSPGREERVV
                     GPGQTYVLDPYRSFQVHWAPGARMTTVRLDREMVERAAADALGIDGSVRARFSLNGATS
                     GAAARSWAGISAAVHREVLGEGVARSSPLVAGHLTQSTAAILMQTHELITQGVDAQRPG
                     EVAHPAVRRAMALAEERADQPLTLADLAAAARVSPRALQEAFRRHVDSTPLGYLREVRL
                     GRAHQELVAARGDGDVTVAEVAYRWGFNNLGRFAGYYQRRYGHPPSRTLRS"
     gene            8097..8885
                     /locus_tag="FGW37_RS22615"
                     /old_locus_tag="FGW37_22865"
     CDS             8097..8885
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603030.1"
                     /locus_tag="FGW37_RS22615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_22865"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_179082718.1"
                     /transl_table=11
                     /translation="MSHAAAFPTTPVGPAGTAVAARATGLSKVYGQGDTRVTALDSVSV
                     EFRRGEFTAIMGPSGSGKSTLMHCMAGLDTISSGSTQIGDVELGSLGDRQLTRLRRDRI
                     GFVFQAFNLLPTLTALENITLPMDIAGRKPDQEWLDMVVGTVGLSGRLSHRPSQLSGGQ
                     QQRVAVARALTAKPEIIFADEPTGNLDSRSGAELLGFLRESVQALQQTIVMVTHDPVAA
                     SYADRVVFLADGRIVDEMREPTADAVLDRMKRFDAKGRTS"
     misc_feature    complement(10092..10107)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 24.73"
                     /tool="antismash"
ORIGIN
        1 tcaggcgcgg ctcgccggac cggacggcgt tgcggtcggc gtccacggcc aggcccagct
       61 gctccaggcc cgccacggcg gcctcgcgca cgggcgccgc gttctcgccg acgccggcgg
      121 tgaaggccac ggcgtcgacc ttgcccagga ccgcgtagta ggcgccgatg tacttcttga
      181 gccggtgcac gtagatgtcg aaggcgagcg ccgcccgctc gtcgccctcg tcgatgcggc
      241 ggcggatctc gcgcatgtcg ttgtcgccgc acaggccgat caggccgctc ttcttgttga
      301 gcagcgtgtc gatctcgtcg gtggacatcc cggcgttacg ggacaggtgc aggatgaccg
      361 ccgggtccag gtcgcccgac cgggtgccca tgaccaggcc ctccagcggg gtcaggccca
      421 tggaggtgtc gacgcacttg ccgccctcga ccgccgaggc cgaggcgccg ttgcccaggt
      481 gcaggacgat gacgttgacc tcggaggggt ccttgcccag cagcttcgcg gtctcgcgcg
      541 agacgtaggc gtgcgaggtg ccgtggaagc cgtagcggcg caccatgtgg gcgtcggccg
      601 tggccacgtc gatggcgtag cgggcggcgg cctccggcat cgtggtgtgg aaggcggtgt
      661 cgaagacggc gacctgcggc aggtcggggc gcagcgcctg cgccgtgcgg atgcccgtga
      721 cgttggccgg gttgtgcagc ggggcgaccg gcacgagccg ctcgatctcc gccagcacct
      781 cgtcggtgat cacggtgggg gcggtgaact tctggccgcc gtgcaccacc cggtggccga
      841 tcgcggcgag ctccggcgag tccaggccca gcccgtccgc ggccagctcc gcggcgaccg
      901 cctgcagcgc ggccgcgtgg tcggcgatcg gcgcctcctg ctcgcgcttg gcgccgcccg
      961 tggcgagcgg ggtgtgcgcg aggcgggagg tctcctcgcc gatgcgctcg accaggccca
     1021 cggccagccg ggcgccgtcg gccatgtcga gcagctggta cttgaccgag gaggagccgg
     1081 agttgaggac gaggactcgg gtggggttgg cagtcatgaa cgctttccgg gttgtggggg
     1141 tcgggggctg ggtctcggac gtcggtgggg gatgccgtac gggaccgggc ggcggtcccg
     1201 tacggccgta cgggcgtcag acggcgggcg cgtgcggcgc ggttccgttc ccggtctcgc
     1261 cctgcgcctg gatcgcggag atcgcgaccg tggtcacgat gtcctgcacc agcgcgccgc
     1321 gggagaggtc gttgacgggc ttgcgcaggc cctgcaggac cgggccgacg gccacggcgc
     1381 cggccgagcg ctggacggcc ttgtaggtgt tgttgccggt gttgaggtcg gggaagatca
     1441 gcacggtggc cttgcccgcg acctccgagc cggggagctt ggtcttggcg accgcggcgt
     1501 ccacggcggc gtcgtactgg atcgggccct cgaccttgag gtccgggcgg cgctcgcgga
     1561 cgatctcggt ggccttgcgc accttgtcga cgtccgcgcc ggagccggag gtgccggtgg
     1621 agtacgacag catcgcgatc cgcggctcga cgccgaactg ggcggcggtc gccgcggact
     1681 ggatggcgat gtccgcgagc tgctcggcgt tcgggtcggg gttgaccgcg cagtcgccgt
     1741 agaccagcac ccggtcggcc aggcacatga agaagaccga ggagacgatc tgtgcgcccg
     1801 gcgcggtctt gatgatctcg aaggccgggc ggatggtggc ggcggtggag tgcaccgcgc
     1861 cggagaccat gccgtcggcg aggccctcct ggaccatcag ggtgccgaag taggagacgt
     1921 cggtgaccac gtcgtgcgcg agctcgacgg tcatgccctt gtgggcgcgg gccttggcgt
     1981 agatctcggc gaagcgctcg cgcagcgggg aggtctgcgg gtcgatgatc tgcgccgcgg
     2041 ccaggtcgat gcccagctcg cccgcgcgct tgcggatcgc gccctcctcg cccaggagcg
     2101 tgaggtcgca gatgtcgcgg cgcagcacca cgtccgcggc gcgcagcacg cgctcctccg
     2161 taccctcggg caggacgatg cggcggcgcg ccgagcggga gcgctcgatc agctcgtgct
     2221 cgaacatcat cggggtgacg cggctggagc gggccacggc gatgcggttc gtcagctccg
     2281 cggtgtccac gtgccgctcg aacaggccga gggccgtctc ggccttgcgc ggcgagaacg
     2341 cgtccagctt gccctcgatc gcgaacagct cggccgcggt cgggaaggag ccgcccggca
     2401 ccgagacgac cggggtgccc ggggccagcc ggtccgcgag cgccaggatg tccgggcccg
     2461 gcttctcgtc cagggtcagc agcacgccgg ctatcggcgg ggcgccggcg ctgtgcgcgg
     2521 cgagggcgcc gacgatcagg tccacccggt cgccgggggt cacgaccagg cagccctcgg
     2581 tcagggcggg taggaagacc ggcagcatgg cgccgccgaa gacgaagtcc ttggcgtcgc
     2641 gggccagacc cgcgtcgtcg ccgagcagca cctcggcgtt cagcttgcgg acgatctgcg
     2701 ccacggtcgg cgcggagagc ccggcctcct cggggagggc gtagcagggg acgggcaggc
     2761 tcgccgacag gcgctcggcg acggcctcgc ggtcggccgg ggcgacccgg ttgacgacca
     2821 gggcgacgac gtcgcagccc agggcctcgt aggcgcggta ggcgttgcgc gcctcggacc
     2881 gcacggactc ggccgtctgg tcctggccgc cgacgaccgt gatcaccgag gcgccgaact
     2941 cgttggcgag gcgggcgttg agggcgagct cgtcggggag cgtggagccg acgtagtcgg
     3001 tgccgagcac cagcacgtac tcgtagtcgc gggcgaccgc gtggaagcgc tcgaccagcc
     3061 gcgagaccag ctcgtccgtg ccgcgctcgg cctgcagcgc ggaggcctcc gcgtagctca
     3121 tgccgtggcc cgactcggcc gactgcccca gccggtagcg ggaccgcagc aggtcgaaga
     3181 ggcggtccgg cccgtcgccg tggacgagcg ggcggaagac gcccacccgg tccacctgac
     3241 gggtgaggag ctccatgact cccagctcga tgacctggcg cccgtcgccc cggtcggtcc
     3301 cggtcacgta cacgctgcgc gtcacgcgtg ctctccttgc tccatcgccg tgttcttcgg
     3361 tgtttcttcg ccgtgtgcgt cggcttaaaa attacccgtt atggtgggct tgacctcttg
     3421 acaatacctg cgcccctggc taaggcgcgc gtcagtacgg cgtccgggcc cgcagggccg
     3481 gaggtcagga ccggcgcggc cccggggtgc gccggtaccc atcggaccgt gaaacaatcg
     3541 gcccggctca catgtaccat ccccttacct tcggtagggg ggaccccaga gcaggagaca
     3601 cagcacgcga tgcgcatcgg agttctcacc gcaggcggcg actgccccgg cctgaacgct
     3661 gtcatccgct cggtggtgca ccgcgcggtc gccggccacg gtgacgaggt catcggcttc
     3721 gaggacggct tcaagggcct gctcgacggc cggcaccgca agctcgacct ggaagcggtc
     3781 agcggcatcc tcgcccgcgg cggcaccatc ctcggctcct cccgcctgga gcgggcccgg
     3841 ctgcgcgagg cctgcgagag ctccaaggag ctcgcccgcg agtacggcat cgacgtgctc
     3901 atcccgatcg gcggcgaggg cacgctgacc gcggcccgga tgctgtcgga cgcgggcctg
     3961 cccgtcgtcg gcgtccccaa gaccatcgac aacgacatct cctccacgga ccgcaccttc
     4021 ggcttcgaca ccgccgtcgg cgtggccacc gaggcgatcg accgcctcaa gaccaccgcc
     4081 gagtcccacc agcgggtgat ggtcgtcgag gtcatgggcc gccacgccgg ctggatcgcc
     4141 ctggagtccg gcatggccgg cggcgcccac ggcatctgcc tccccgagcg ggccttcgag
     4201 gtcgacgacc tcgtgaagat ggtcgaggag cgcttcgccc gcggcaagaa gttcgccgtc
     4261 atctgtgtcg ccgagggcgc gcaccccgcc gagggctcga tggagtacgc caagggcgcc
     4321 atagaccagt tcggccacga gcgcttcgcc ggcatcggca ccaagctcgc cgccgagctg
     4381 gagaagcgcc tgggcaagga ggcccgcccg gtcatcctcg gccacgtcca gcgcggcggc
     4441 acccccaccg cgtacgaccg cgtcctcgcc acccgcttcg gctggcacgc cgtcgaggcc
     4501 gcccaccgag gcgacttcgg caagatgacc gcgctgaagg gcaccgacat caagatggtg
     4561 ccgatcgccg acgccgtcac cgagctcaag cgcgtaccgg agagccggat ggacgaggcg
     4621 gagtcggtct tctagacccc ttcgtcccct tcttctccct tcttctccct tcttctctcg
     4681 cgaggccctc gccgacctgg tcggcgaggg cctcgtggct tttggtgagg gatgccacgc
     4741 tttggccgtt acgccggaaa acttccggcc atatgcgtca tgcgcacaag attctcccgt
     4801 ggcggccggg atccgcccca cctctttccg gaagccccct ttattaatac agcctcatat
     4861 tggctctatc tggctacatg tccggctctt cccgaagatc tgttacgttc atgatcatct
     4921 acgccggtcg gggggtcggg ggagctcgac gagctggacc ccctggtcgg aaggaacgtt
     4981 tcttctgaag ggggacccgg gtgtccgacc tcacccgccg ccgcatgctc ggccgtaccg
     5041 ccgccgctgc cgccggaatc gtgctcgccg gaccggccgc gcaggccttc gccgccgaga
     5101 gcgggcacga ccaccatggc aacggcaatg gcaatggcaa cggctccggc caccggccgt
     5161 tcgacgagat ctacgagggc cgccgcatcg agggccggct cacctccggc accggcggcc
     5221 accacgactt cggcatcgcc gtcttcgtcg acggccgccc gctgcacatc atgccgcgcg
     5281 gcaacggctg gatcagcgtc atgaaccact acgaggtctt cgcgtcgccg tacgaggtga
     5341 cccgcgccgc cgtgcgggcg ctgcgcggcg tcaacctcgt ctgagccacc tgatcccatt
     5401 tccgtaaagg gccacattct catggcagtt cgcaagaacc aggcaaagct caccaaggcc
     5461 gagcggcgcg acttcgtgga ggcgctgctg gagctcaagc gccgcggcgg ctacgacaag
     5521 tacgtcgaga tccacgaccg cttcgtgatg agcgacctgg acgaccagga gcgcaccggc
     5581 cacgtctcgc cgtcgttcct gccctggcac cggcagttcc tgctcgactt cgagcgggac
     5641 ctgcagtccg tcaacccggc cgtcacgctc ccgtactggg acttcacggt caaccgctcg
     5701 ctgtccgacc cgatcttcgc ccccgacttc ctcggcggca acgggcgcga gcgcgacgcc
     5761 caggtcatgg acggcccgtt cgcctacagc ggcggccgct ggccgatcta cttcaaggcc
     5821 gacgaacgcc ccttcctgat gcgggagatg ggccgcagcg cgaccacgcc gcagctgccc
     5881 acggccgcca cggtcgaggc cgcgctggcc gccccgtact acgacgaggc cccctggaac
     5941 tccacctcca aggccggctt ccgcaacctc gtcgagggct gggcgaacgg caacaccggc
     6001 ccgcacaaca ccgtgcaccg ctgggtcggc ggccacatga acaccggcat gtcgcccaac
     6061 gacccggtgt tctggctgct gcactgcttc atcgacaagc tgtggtccga ctggcagcgc
     6121 cggcacccga aggcgcccgc ctacctgccg gtcgagccgg tcaaggacat cgtcgccctc
     6181 aacgagccca tgaagccgtg gagcgagaag gggcagcggg tcacccccgc cgacatgatc
     6241 gaccacagga agttctacgc gtacgacacc gacgcggcgt gagcggcggc gcgtaagcgg
     6301 cggagggggg aagcggggga gcggggggag cgggggcggg ccgggtcatc cggtccgccc
     6361 ccgccgcatt cccgcgtccc gccgcccgca cccggccgtg accgctacgc ccgccgccac
     6421 gacgagcagg ccccggcccg cgccgccctg ccgcggggcg tgagcggggc gaggtcccga
     6481 ggtcgacagc cgaggtcact tgtccgctgc cctacgaggc gggccggttg attaccgccc
     6541 cgaagacgta gcaactctcc cggcgcactg cgcacaagcg aagaccccgc cgtctgtccg
     6601 ctgacggcgg ggcgcccccg cttgcgggac cggccctgga tgtcccccgt gaacccaggg
     6661 ccgtgacccg cttccccccg acggggccct gtcccgaaac agccgtggga ccggcccgcg
     6721 ccttgactgc ggacaagggg aacggtacta acggggccgt ccatcggcta ctcgccgaac
     6781 gcggcacctg tcccggaaac gcggacaccc gagggaagcc cctgatgact gaaccaggcg
     6841 tggggcccga ggcccccggc aacatgcgca cgctcgtcct cagcaacgac ctcgacgaga
     6901 ccagggagat catcagctct gcctacagtc cttatcaact cagcgtgctc ggcgacccga
     6961 aggagttctc cgcgtggtac gcggagggcg gcttcccggg gatcacggtg tcggggctgc
     7021 agtacggcgc cgagacgctc gtcgcacccc agcccctcga ctcgtacctc ctggtctgcc
     7081 agctggtacg gggccgggtg cgggtgatgt cgccggggcg ggaggagcgg gtcgtcgggc
     7141 ccgggcagac gtacgtgctc gacccgtacc gctccttcca ggtgcactgg gcgcccggcg
     7201 cgcggatgac gaccgtccgg ctggaccggg agatggtgga gcgggcggcg gccgacgcgc
     7261 tcggcatcga cggttccgta cgggcccgct tctcgctcaa cggggccacc tccggggcgg
     7321 ccgccaggag ctgggccggg atctcggcgg ccgtgcaccg ggaagtgctc ggcgagggcg
     7381 tggcccgcag cagcccgctc gtggccgggc acctgacgca gtcgacggcc gcgatcctca
     7441 tgcagacgca cgagctgatc acccagggcg tggacgcgca gcgcccgggc gaggtcgcgc
     7501 accccgcggt gcgcagggcg atggcgctgg ccgaggagcg tgccgaccag ccgctcacgc
     7561 tggccgatct cgcggcggcg gcgcgggtga gcccgcgcgc cctgcaggag gcgttccggc
     7621 ggcacgtgga ctccacgccg ctggggtacc tgcgcgaggt gcggctgggc cgggcgcacc
     7681 aggagctggt ggcggcgcgc ggcgacggcg acgtcaccgt ggccgaggtg gcctaccgtt
     7741 ggggtttcaa caaccttggc cggttcgcgg ggtactacca gcggcgctac gggcacccgc
     7801 cgtcccgcac gctgcgttcg tgagtgccgg agtcttcgtg agtgccgggg cttgctcccg
     7861 ggcgggcccg tagggcgccc cgtgggtcct ggggatgacg gtgtccgtct cagggactac
     7921 gcggggcacc ctcccgtggg ccttcagggc gtacggcttt ccggccgtac ggctgacgcc
     7981 cggcgcccgc cgcgccccga gaattggagg agttgattcc ggccatggtg tccccgggaa
     8041 ttcccggcgc ggaccgatga ccggaccccc ttcccctacc tcccggagga gaccccgtgt
     8101 cccacgcggc cgcctttccc acgacccccg tcggcccggc cggcaccgcc gtcgccgccc
     8161 gagccaccgg tctgagcaag gtctacggcc agggcgacac ccgcgtgacg gcgctggact
     8221 ccgtctccgt ggagttccgc cgcggcgagt tcaccgcgat catgggaccc tcgggctccg
     8281 gcaagtccac gctgatgcac tgcatggcgg gcctcgacac gatctcgtcc ggctcgacgc
     8341 agatcggcga cgtggagctc ggctcgctcg gcgaccggca gctgacgcgg ctgcgccggg
     8401 accggatcgg ctttgtcttc caggcgttca acctgctgcc gacgctcacc gccctggaga
     8461 acatcaccct ccccatggac atcgcgggcc gcaagcccga ccaggagtgg ctggacatgg
     8521 tggtcggcac cgtcggcctg tcggggcggc tctcgcaccg gcccagccag ctctcgggcg
     8581 gccagcagca gcgcgtggcc gtggcccgcg cgctcaccgc caagccggag atcatcttcg
     8641 cggacgagcc caccggcaac ctcgactccc gctccggcgc cgaactgctg ggcttcctgc
     8701 gcgagtccgt ccaggccctg cagcagacga tcgtcatggt cacccacgac cccgtggccg
     8761 cctcctacgc cgaccgcgtg gtcttcctcg ccgacggccg gatcgtggac gagatgcgcg
     8821 agcccaccgc ggacgcggtc ctcgaccgca tgaagcgctt cgacgccaag ggccgtacga
     8881 gctgaagggc cgtacgagct gagggacggc gccgccgcct cccgcacccg acggccccgc
     8941 acgggcccct ccgcactgca cgcttctgcg ccgctccccg cgggctcctc ccccaggaca
     9001 gaccatgttc cgtaccgccc tgcgcaacct cctcgcgcac aaagccaggc tgatgatgac
     9061 cgccctcgcg gtcctcctcg gcacggcctt cgtctccggc accctgatat tcagcgactc
     9121 cgtcggtgcc gcctaccgca acaagatggc caagagcctc gacgacgtcg cggtctccgt
     9181 caccaccggc cactccaaca tcgccatgaa gggcatccgg acactcgacg accgcgccgt
     9241 cgcgaccgtc cgtgccctgc cgggcgtggc gtccgtacgc ccgtccgtca gcggcgtcgc
     9301 catgatcgcc gaccggcaga acaaccccgc cggcagcgag tggggcagct ccggcgccaa
     9361 ctacgtcccc ggcaaggacg gcaaggacag ccgctacccg atcgtcaagg gccgcgggcc
     9421 cgccgccgag ggcgagatcg tcctcgacgc gaagaccgcc gcgaagacgg gcgccgcgat
     9481 cggcggcacc gtccggctgg ccatcgacgg cccggtgatg accaagaagc tcgtcggcat
     9541 cgccgagacc gacgacccgc gggtgagcgc cggcggcagc ctcgcgctgt tcgacaccgc
     9601 gaccgcgcag aaactcttcg gcaagcccgg cgagttcagc gagctcgtcg tctccgcgaa
     9661 gcccggcacc gaccagcaga agctgaccgc cgacgtccgc aaggtgctgc cggaggcctt
     9721 cagggtgcag agcgggaagc agctggccgc cgaccagtcg aaggcgatcg acaaggagac
     9781 cagctcgatc cgcaacacct tcctggcgtt cgcgggcatc gccctcttcg tcggcatctt
     9841 catcatcgcc aacaccttca ccatgctcat cgcccagcgc agccgggaga tcgcgctgct
     9901 gcgcgcggtg ggcgcctcgc gccgccaggt ggtgcgctcg gtgctgatcg aggcggggct
     9961 gctgggcctg gtcgcctccg ccgcgggctt cgtcctcggc ctgggcgtcg ccaccggcct
    10021 gcgcgcggtg ctgaactcgg ccggcgcgag cctgccggac gggccactgg tcatcgagcc
    10081 ggcctccgtg ctgctcgccc tcggcgtcgg cgtcgtggtg actgtgctcg ccgcctggct
    10141 gccctcccgc aaggccgcga agatcgcccc cgtcgaggcg ctgtccaccg tggaacagcc
    10201 gccggccgtc aagagcctcg tcgttcgcaa cggcatcggt gccgtgctca ccggcctggg
    10261 cgtcgcgatc atgctgtacg tcaccacgct caaggacagc gacggcctgc cgaccgcgat
    10321 ggcgggcgcg gccctgacca tggcgggcgt catcgttctc gccccgctgc tctcccgccc
    10381 gatc
//
