LOCUS       NZ_CP040752            10399 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces rectiverticillatus strain B15-08 chromosome, complete
            genome.
ACCESSION   NZ_CP040752
VERSION     NZ_CP040752.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces rectiverticillatus
  ORGANISM  Streptomyces rectiverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7679243)
  AUTHORS   Park,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAY-2019) Laboratory of Bioorganic Chemistry, NIDDK,
            NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: DEC-2018
            Assembly Method                   :: HGAP v. Dec-2018
            Assembly Name                     :: DDK_LBC_B15-08
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013394065.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:49:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,642
            CDSs (total)                      :: 6,543
            Genes (coding)                    :: 6,394
            CDSs (with protein)               :: 6,394
            Genes (RNA)                       :: 99
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 55 of 149
            Pseudo Genes (incomplete)         :: 125 of 149
            Pseudo Genes (internal stop)      :: 12 of 149
            Pseudo Genes (multiple problems)  :: 41 of 149
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:46:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2578603
            Orig. end                         :: 2589002
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040752.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from LBC, NIDDK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="22"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(453..953)
                     /locus_tag="FGW37_RS11090"
                     /old_locus_tag="FGW37_11215"
     CDS             complement(453..953)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146259.1"
                     /locus_tag="FGW37_RS11090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_11215"
                     /product="FBP domain-containing protein"
                     /protein_id="WP_179080917.1"
                     /transl_table=11
                     /translation="MQSLADNDIRASFINCSKGEARRIALPRNLSELPWEDLDFLGWRD
                     PGAPDRGYVVAEREGKLVGVTLRVPQGGPRSMAKSTMCSLCLTAHPGSGVSLLAARRVG
                     PAGREGNTVGAYMCADLACSLYVRGKKVPQMAMRYKETLSVEERISRMLVNLDDFLGKV
                     ERG"
     misc_feature    1047..1061
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.48"
                     /tool="antismash"
     gene            1086..2267
                     /locus_tag="FGW37_RS11095"
                     /old_locus_tag="FGW37_11220"
     CDS             1086..2267
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156247.1"
                     /locus_tag="FGW37_RS11095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_11220"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_246430348.1"
                     /transl_table=11
                     /translation="MAGTPGTPRVLRAMNDRAALDLLVAHGPLTRTRLGELTGLSKPTA
                     AQLLTRLEAAGLVRRTGTVTGRPGPGAGLYEIDPGIAHVAALSVGPEGVTALVADIAGT
                     VAGEHRVPAEQGEGAAKLVGRAVDGALAAAGLGRDALHRTVIGTPGALDPRTGLLRYAP
                     HLPDWRSPTLLEELAGVTGTPVVVENDVNLAAVAEQHAGAARGFANYVLLWADEGVGAA
                     VVLGGTLLRGATGGAGEIGYMPLPGAPLARGGDDATAGPDGGGGFQMLVASPAVVALAR
                     AHGLDARTAPEALARAAAEPGAGDDVYAELGRRLAVGLAAVVAVVDPELVVLSGAVCRA
                     GGERLRAMVEAELTGLALPRPQLRLSTVEDRPVLAGALRTALAAARETVFDTA"
     gene            2326..3564
                     /locus_tag="FGW37_RS11100"
                     /old_locus_tag="FGW37_11225"
     CDS             2326..3564
                     /EC_number="3.2.1.86"
                     /GO_function="GO:0008706 - 6-phospho-beta-glucosidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982423.1"
                     /locus_tag="FGW37_RS11100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_11225"
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="WP_179084632.1"
                     /transl_table=11
                     /translation="MGGGSTYTPELVDGFARLHATLPVTELVLIDPDAERLELVGALAR
                     RILARQGHPGRVTWTADPDAGVDGADAVLLQLRVGGQAARQQDETWPLECGCVGQETTG
                     AGGLAKALRTVPVVLDIAERVRRRSPDAWIVDFTNPVGIVTRALLAAGHRAVGLCNVAI
                     GFQRKFARLLGVAPEEVALEHVGLNHLTWERSVTVGGEDVLPRLIAEHGDAVAADLRMP
                     RSVLDRLGVVPSYYLRYFYGHDEVVRELRTKPSRAAEVAAMERRLLALYADPALDEKPA
                     LLAKRGGAFYSEAAVALTASLLRDTGDVQVVNALNNGTLPFLPDDAVIEVPAAVDARGA
                     RPLPVRPLEPLYAGLVANVTAYEHLALEAALKGGRDRVFRALLAHPLVGQVDHADRLTD
                     ALLAHNREHLAWV"
     gene            3555..4547
                     /locus_tag="FGW37_RS11105"
                     /old_locus_tag="FGW37_11230"
     CDS             3555..4547
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605591.1"
                     /locus_tag="FGW37_RS11105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_11230"
                     /product="BadF/BadG/BcrA/BcrD ATPase family protein"
                     /protein_id="WP_179080918.1"
                     /transl_table=11
                     /translation="MGVSGALLAIDAGNSKTDVVLAGPDGAVLGAARGGGFQPVQAGVR
                     QAVDGLAALVERAAAAAGTAAPPYAAHVSACLANCDLPVEEELLSAEIAARGWGRTVAV
                     ANDTFALLRAGLPDGGEPVGVAVVCGAGINCAGLGPGGRTARFPAIGRLSGDWGGGACL
                     AEEALWSAARAADGRGGPTALARALPAHFGLDGMPALIEALHLGRVAAERRHELVPVLF
                     AAAAAGDAVARGLVARQAAEVVTMAAVALERLGLLGAGVPVVLGGGVLAARHPLLHEQV
                     VALLAGRAPQAVPVVVTAPPVLGAALLALDRAGAPAAAHARLRAHYGDA"
     misc_feature    complement(4629..4647)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.91"
                     /tool="antismash"
     misc_feature    4649..4663
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.14"
                     /tool="antismash"
     misc_feature    4649..4664
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.35"
                     /tool="antismash"
     misc_feature    complement(4649..4666)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.23"
                     /tool="antismash"
     misc_feature    complement(4667..4682)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     misc_feature    4763..4777
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.94"
                     /tool="antismash"
     misc_feature    4827..4842
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.73"
                     /tool="antismash"
     misc_feature    4832..4841
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     misc_feature    complement(4879..4893)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            5001..5399
                     /locus_tag="FGW37_RS11110"
                     /old_locus_tag="FGW37_11235"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038019.1"
                     /locus_tag="FGW37_RS11110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_11235"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_179080919.1"
                     /sec_met_domain="melC (E-value: 5.5e-42, bitscore: 141.8,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSNVSRRVVLRGTAAAAAGVALLATGARAADHTGHTTDHTGHGG
                     HGTGPAAFDEVYKGRRIVGKPVTSGEHAAHGGFAVTIDGKELHVMQNADGTWISVVNHY
                     QVFDQPLALTRAAVDALRGATLVPIAMN"
     gene            5461..6282
                     /locus_tag="FGW37_RS11115"
                     /old_locus_tag="FGW37_11240"
     CDS             5461..6282
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091617.1"
                     /locus_tag="FGW37_RS11115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_11240"
                     /product="tyrosinase family protein"
                     /protein_id="WP_179080920.1"
                     /transl_table=11
                     /translation="MAVRKNQANLTATEKRNFVNAVLELKRTGVYDGFVRTHNEFIMSD
                     RDDSDRVGHRSPSFLPWHRRFLIQFEQELQKIDSSVTLPYWDWTVDRSVNSSIFGADFM
                     GGNGRSRDAQVTTGPFAYSTGKWTINVSVDNRNFLQREMGAAGTLPTRAQVDAVLAMPV
                     YDTAPWNSASEGSFRNYLEGWRGAGRVHNNIHVWMGGQMATGVSPNDPVFWLHHCHIDK
                     LWSDWQRMHPASAYLPAAGTANVVDLNDTMRPWNNVTPAQMLDHSSYYTYA"
     gene            6624..7928
                     /locus_tag="FGW37_RS11120"
                     /old_locus_tag="FGW37_11245"
     CDS             6624..7928
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944859.1"
                     /locus_tag="FGW37_RS11120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_11245"
                     /product="hypothetical protein"
                     /protein_id="WP_179084633.1"
                     /transl_table=11
                     /translation="MRAAAVTEPGRLRVIGAVLAVVLVAFGAVTAWQVASRAAAADSVV
                     RTSQPLSADAADIYRSLADADTTAASGFLAGGQEPRAVRQRYEKDIALASRLLVKAAAN
                     ADASATARARIATLNEGLPRYTGLVEAARANNRQGLPLGGAYLRYAGDRMRGELLPAAR
                     GLYEAETDRLGSDYDDAQSWPWAALALGVAALGTLAWAQRRNYLRTNRVFNHGLLAATA
                     AAGVVLLWLVAGHAVARSGLETSYTHGAKSLQALNEARIGSLQARGDENLAMVARGAVL
                     GKNGDDAYETGYRDGMGRLVGGSQGPARPDTLLERARALADDAEGRDPVEAAVKDVREW
                     QQRHGQARALADDRGDYDDALRKVIGDKDSTGASFDRVDTELQRAIAHEQAEFRQEADD
                     GRGAFSGLAAGAAVLTVLGAAGAVLGVGRRLSEYR"
     gene            7964..8962
                     /locus_tag="FGW37_RS11125"
                     /old_locus_tag="FGW37_11250"
     CDS             7964..8962
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605588.1"
                     /locus_tag="FGW37_RS11125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_11250"
                     /product="glutamate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_246430349.1"
                     /transl_table=11
                     /translation="MAGARTGKRMRAGPAAVAAAVCALAAAAAAVLPTGGAPAQDRPAR
                     TAAPAAPAAPAPGAAAAPAQCTDPEASLRPAGGADGAAVQRIKARGRLIAGVDQNSYRW
                     GYRNPADGELSGFDIDLVRAVAKDILGDPGKVTYLAIPTSRRISALQTGKVDIVARTMT
                     ITCERIKQVAFSTAYFESGQQVMVPKGSPVTAFDDSLKGKKVCTAEGSTAEIKVREEPH
                     GSTLLTVPNQLDCLVRLQLGEVDAVVNDRALAAGQAAQDPSVQLVGKPFTTEPYGVAMN
                     LADTDLVRRVNKVLEDYRAGGAGSLWMKAYDKWLAADLKGITAPPAPKYRD"
     gene            9034..10392
                     /locus_tag="FGW37_RS11130"
                     /old_locus_tag="FGW37_11255"
     CDS             9034..10392
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660331.1"
                     /locus_tag="FGW37_RS11130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_11255"
                     /product="hypothetical protein"
                     /protein_id="WP_179080921.1"
                     /transl_table=11
                     /translation="MAVAEPTGPALTREEVDRALARLGAEHEAVESSLLALQDHAGRRL
                     LEGAELTGETRSRWAAAEALIGQLWAYFDAYTAALTAARELRARRRWPTQGELSELTEL
                     LRGSGITLPGHGTAALGTAGLPAGAVGTAGMTGMTARLSEQLSLQELLDRMNGWYARAL
                     DVVVIADAVWSALPARIDLLAAELGRTRSLAHSVGVRPGEHPSGDDLEQITRELAALRE
                     EVISDPVAFWAGSSPSSAPGGGRPDTTRYDRAARALEDVRREVEAVLDVRQDAERRLMR
                     VRDVLSRADRTLNEARQARVEVLSKIAASVVPAVSGPPTALYEQLAAAAEHRRHARWHR
                     LSPLLEGLEQRSEEELLRARESLTAVTAPLAVRAELRGRLDAYKAKTARHGLAEDSLLI
                     ERYDAARRMLWSAPCDLVAAEQAVLRYQQALAETLSAAAPGTGERPTGRRGEA"
ORIGIN
        1 acccgcacgg gtgaggagat gcagaaggcc gagccgtgga ccgagcggct gtgggagccc
       61 gtcgaggtgc tgggcctgag cgcgacctac ctcgactcgg tggtcgtccg ggtgtccgcc
      121 aagaccatgc cgggcaaggc gctcggcgtc gagcgcgagc tgcgctggcg catcaagcag
      181 gcgctggacg cggagggcat ccgcatcgtg ggccgcccgg cggaggcaaa cttggaggtg
      241 ggggcgacgc agggggccga cccgatggcg gccgtggccg caccgtccgc cctggcgaac
      301 ccggcgtccc cgcagtccca ggccacgacg cccataccgc cggtcgtgcc gggcgcggcc
      361 ctgggcaagt gacggcggcg cggcggcccc gccgcggtgc ggtccgggcc cgcgcggcgt
      421 agcccggcgc acggcccggc gtgccgctcc ggctagccgc gctcgacctt gcccaggaag
      481 tcgtccaggt tcacgagcat gcgggagatc cgctcctcca cgctcagcgt ctccttgtac
      541 cgcatcgcca tctgcgggac cttcttgccg cgcacgtaga gcgagcaggc caggtccgcg
      601 cacatgtacg cgccgaccgt gttgccctcg cgcccggccg ggccgacccg ccgggcggcg
      661 agcagggaga cgcccgagcc cgggtgcgcg gtcaggcaca gcgagcacat cgtggacttc
      721 gccatgctcc gcggcccgcc ctgcggcacc cgcagggtca cgccgacgag ctttccctcg
      781 cgctcggcga cgacatagcc gcggtccggc gcacccggat cccgccagcc caggaagtcg
      841 aggtcctccc aggggagttc cgagaggttg cgcgggaggg cgatccggcg cgcctccccc
      901 ttggagcagt tgatgaagga cgcgcgtatg tcgttgtcgg cgagggattg catggtcagc
      961 gaaattaaca ccgttcgggc ggatcgtcgc atgattttcg ggccgggcga ttgacgcccc
     1021 gccaggccgt tccctagcct ctccccgtat caataggaaa gtttcctaac agtcagggta
     1081 cggagatggc cgggaccccc gggacaccgc gcgtgctgcg cgccatgaac gaccgcgccg
     1141 ccctcgacct gctcgtcgcg cacggccccc tcacccgcac ccgcctcggc gagctgaccg
     1201 gcctgtccaa gcccaccgcc gcccagctgc tcacccgcct ggaggccgcc ggcctggtgc
     1261 gccgcaccgg caccgtcacc gggcggcccg ggcccggcgc cgggctgtac gagatcgacc
     1321 cgggcatcgc ccacgtcgcc gcgctgtccg tcggccccga gggcgtcacc gcgctcgtcg
     1381 ccgacatcgc cggcacggtg gccggcgagc accgcgtgcc cgcggagcag ggcgaggggg
     1441 cggccaagct cgtcggccgg gccgtcgacg gcgccctcgc cgccgccggg ctcggccgcg
     1501 acgcactgca ccgcaccgtc atcggcaccc ccggcgccct cgacccgcgc accggcctcc
     1561 tgcgctacgc cccgcacctg ccggactggc gctcccccac actgctggag gagctcgccg
     1621 gggtcaccgg cacgcccgtc gtcgtcgaga acgacgtcaa cctcgccgcc gtcgccgagc
     1681 agcacgccgg cgcggcccgg ggcttcgcga actacgtcct gctgtgggcc gacgagggcg
     1741 tcggcgccgc cgtcgtcctg ggcggcaccc tgctgcgcgg cgcgaccggc ggcgccgggg
     1801 agatcggcta catgccgctg ccgggcgcgc cgctcgcgcg cggcggggac gacgccaccg
     1861 cgggccccga cggcggtggc ggcttccaga tgctcgtcgc ctccccggcc gtcgtcgcgc
     1921 tcgcccgcgc ccacggcctc gacgcccgta cggcccccga ggcgctcgcc cgcgcggcgg
     1981 cggaaccggg cgcgggcgac gacgtctacg ccgaactggg caggcggctg gccgtcgggc
     2041 tcgcggcggt cgtcgccgtg gtcgaccccg aactggtggt gctctccggc gccgtgtgcc
     2101 gggcgggcgg cgagcggctg cgcgcgatgg tggaggccga gctcaccggg ctggccctgc
     2161 cccggccgca gctgcggctg agcaccgtgg aggaccgccc ggtcctggcg ggggcgctgc
     2221 gaaccgcact cgcggcggcc cgggagaccg tgttcgacac ggcgtgagcc attcgccgct
     2281 ctggcctggc aaccagcaaa ggagtcaagg gtgaagctcg cagtagtggg tggcggatcc
     2341 acctacaccc ccgaactcgt cgacggcttc gcgcggttgc acgccacgct gccggtgacc
     2401 gagctcgtcc tgatcgaccc ggacgcggag cggctggagc tcgtcggcgc gctggcgcgg
     2461 cggatcctcg cccggcaggg ccaccccggc cgcgtcacct ggaccgcgga cccggacgcg
     2521 ggcgtggacg gcgcggacgc cgtgctgctc cagctgcgcg tgggcggcca ggctgcccgg
     2581 cagcaggacg agacctggcc gctggagtgc ggctgcgtcg gccaggagac caccggcgcg
     2641 ggcgggctcg ccaaggcgct gcgcacggtc ccggtggtgc tggacatcgc cgagcgggtg
     2701 cggcggcgca gcccggacgc ctggatcgtg gacttcacca acccggtcgg catcgtgacg
     2761 cgggcgctgc tggcggccgg gcaccgggcc gtgggcctgt gcaacgtggc catcggcttc
     2821 cagcggaagt tcgcccggct gctgggggtc gccccggagg aggtggcgct ggagcacgtg
     2881 ggcctcaacc acctcacctg ggagcggtcg gtgacggtgg gcggcgagga cgtcctgccg
     2941 cggctgatcg ccgagcacgg cgacgccgtc gcggccgatc tgcgcatgcc gcgctcggtg
     3001 ctggaccgcc tcggcgtcgt cccctcctat tacctgcgct acttctacgg gcacgacgag
     3061 gtcgtccggg agctgcgcac caagccctcg cgcgccgccg aggtggccgc gatggagcgg
     3121 cggctgctgg ccctgtacgc cgatcccgct ctggacgaga agccggcgct gctggcgaag
     3181 cgcggcggcg ccttctactc ggaggcggcg gtcgctctga ccgcgtcgct gctgcgggat
     3241 acgggggacg tccaggtcgt caacgccctc aacaacggca cgctgccctt cctgcccgac
     3301 gacgcggtga tcgaggtgcc ggcggcggtg gacgcgaggg gcgcgcgccc cttgcccgta
     3361 cgcccgctgg agccgctgta cgccgggctg gtcgcgaacg tcacggcgta cgagcacctg
     3421 gcgctggagg ccgcgctcaa ggggggccgc gaccgggtct tccgggcgct gctcgcccac
     3481 ccgctggtcg ggcaggtcga ccacgccgac cggctcaccg acgccctcct cgcgcacaac
     3541 cgggagcacc tcgcgtgggt gtgagcggcg cgctgctcgc gatcgacgcg ggcaacagca
     3601 agaccgacgt ggtgctggcg gggccggacg gcgccgtgct cggggccgcg cgcggcgggg
     3661 ggttccagcc ggtgcaggcg ggcgtgcggc aggcggtgga cggcctggcg gcgctcgtgg
     3721 agcgggccgc cgctgccgcg gggacggccg caccgccgta cgccgctcac gtcagcgcgt
     3781 gcctggccaa ctgcgacctg ccggtggagg aggagctgct gagcgcggag atcgccgccc
     3841 gcggctgggg gcggacggtc gccgtcgcca acgacacctt cgcgctgctg cgggcgggcc
     3901 tgcccgacgg gggcgagccc gtgggcgtcg cggtggtgtg cggggcgggc atcaactgcg
     3961 cggggctcgg accgggcggc cgcacggccc gcttccccgc gatcgggcgg ctctccggcg
     4021 actggggcgg cggcgcgtgc ctggcggagg aggcgctctg gtcggcggcg cgcgccgccg
     4081 acggccgcgg cgggccgacc gcgctggccc gcgccctgcc cgcgcacttc ggcctggacg
     4141 gcatgcccgc gctgatcgag gcgctgcacc tgggccgggt ggcggcggag cggcggcacg
     4201 agctcgtacc ggtgctgttc gcagcggcgg ccgcgggcga tgcggtcgcc cgcggcctcg
     4261 tggcccggca ggcggcggag gtcgtcacca tggccgcggt cgcactggag cggctggggc
     4321 tgctgggggc cggggtgccg gtagtgctgg gcggcggggt gctcgcggcc cggcacccgc
     4381 tgctgcacga gcaggtggtg gcgctgctgg ccgggcgggc gccgcaggcg gtgccggtgg
     4441 tggtcacggc gccgccggtg ctgggcgcgg cgctgctggc gctggaccgc gccggggctc
     4501 cggcggcggc tcacgcccgg ctgcgggcgc actacggcga cgcgtaggcc gggcggcacg
     4561 gggtccgttc ggcgcctgtt tcccgcgtgg cgaccgatat ctcggaatct gtcgttccgt
     4621 ggccggaatc tgcgaaaccg tcgccttctt cacgtcatgt tcacatcgtg agaggcgtca
     4681 ccacacccca ccccgaaccg gaagatctct cgtcgggggc cctcacgacg gccgtctttc
     4741 ctgacatggc gtcaacaacg ccattcgtca gaaatttctc ccagggcatt ggttgaccat
     4801 tcatttacct aatgtcccaa aatcggtcaa ccatttttcg acccctcctc ggtcatgcaa
     4861 gcatccgccc gcacggattg atcacgaaat acaacaagca accgccatca aaagggattt
     4921 acggctgcat tcgtgacaac ttccgccact gatcgtccat tccgcgcctt gtcggcgcgc
     4981 aatcgagggg ggaccgaccc atgtcgtcca acgtcagccg acgcgtcgtg ctcagaggaa
     5041 ccgccgctgc cgccgccgga gtggcgctgc tcgccaccgg cgcgcgggcg gccgaccaca
     5101 ccggccacac caccgaccac accgggcacg gcgggcacgg caccggcccc gctgcgttcg
     5161 acgaggtcta caagggccgc cgcatcgtcg gcaagccggt gacgagcggc gagcacgcgg
     5221 cccacggtgg cttcgccgtc accatcgacg gcaaggagct gcacgtcatg cagaacgccg
     5281 acggcacctg gatcagcgtg gtgaaccact accaggtctt cgaccagccg ctggcgctga
     5341 cccgcgccgc cgtcgacgcc ctccgcggcg cgacgctcgt cccgatcgcg atgaactgac
     5401 cggccactgc cgcacgcacc ccaccgaccc acacttctca ctcacgagga cacgaacccc
     5461 atggcagtgc gcaagaacca ggcgaacctg accgccaccg agaagcgcaa cttcgtcaac
     5521 gccgtgctgg agctcaagcg caccggtgtc tacgacggct tcgtccggac gcacaacgag
     5581 ttcatcatga gcgaccgtga cgacagcgac cgcgtcggcc accgctcccc ctccttcctc
     5641 ccctggcacc gccgcttcct gatccagttc gagcaggagc tgcagaagat cgactcctcg
     5701 gtcacgctcc cctactggga ctggaccgtc gaccgctcgg tcaactcctc gatcttcggc
     5761 gccgacttca tgggcggcaa cggccgcagc cgcgacgcgc aggtcaccac cggcccgttc
     5821 gcctactcca cgggcaagtg gaccatcaac gtcagcgtcg acaaccgcaa cttcctgcag
     5881 cgcgagatgg gcgccgccgg cacgctgccc acccgcgccc aggtcgacgc cgtcctcgcc
     5941 atgccggtct acgacacggc cccgtggaac agcgcctccg agggcagctt ccgcaactac
     6001 ctcgagggct ggcgcggcgc gggccgcgtc cacaacaaca tccacgtgtg gatgggcggc
     6061 cagatggcca ccggcgtctc ccccaacgac ccggtcttct ggctgcacca ctgccacatc
     6121 gacaagctgt ggtccgactg gcagcgcatg cacccggcgt ccgcctacct gccggccgcc
     6181 ggcaccgcga acgtcgtcga cctcaacgac accatgcgcc cgtggaacaa cgtcaccccg
     6241 gcccagatgc tcgaccacag ctcgtactac acctacgcgt aaggcaggca cctacgcgta
     6301 aggcgcggcg cgcgacaggc tcacacgcct ccggcccggt gcggggaacc gcgccgggcc
     6361 ggcgggcgtg atggggaacg agggccgcca cgggccccgg tggagatcgc gatccgaaca
     6421 agatcgcacc ggcaccggtg tgtttgtcag tccttgcggc catactgctg gccgggcacc
     6481 tgttcccggc cggcaccggg caacgggccg ccctcagcga ccgaggggga ggtcacgtgt
     6541 cacagccgca gccggccggc gggccgcgag gagcgcccgg ccgcagcacc tccggcccgg
     6601 cctggcgcga ggggctcgac cgcgtgcggg ccgcggcggt caccgagccc ggcaggctgc
     6661 gggtcatcgg ggccgtcctg gccgtggtcc tcgtcgcgtt cggtgcggtc accgcctggc
     6721 aggtcgcctc cagagccgcc gcggccgact ccgtcgtccg caccagccag ccgctcagcg
     6781 ccgacgccgc cgacatctac cgctcgctcg ccgacgccga caccaccgcg gcgagcggct
     6841 tcctcgcggg cggccaggag ccgcgcgcgg tccgccagcg ctacgagaag gacatcgcgc
     6901 tcgcctcccg gctgctggtg aaggccgccg cgaacgccga cgcctcggcc acggcacgcg
     6961 cccgcatcgc caccctcaac gagggactcc cgcgctacac cggcctcgtg gaggccgcgc
     7021 gcgccaacaa ccgccagggc ctgccgctcg gcggcgccta cctgcgctac gcgggcgacc
     7081 ggatgcgcgg ggagctgctg cccgccgccc gaggcctgta cgaggccgag acggaccgcc
     7141 tcggctccga ctacgacgac gcccagtcct ggccgtgggc cgccctggcc ctcggcgtcg
     7201 ccgcgctcgg caccctcgcc tgggcccagc gccgcaacta cctccggacg aaccgggtct
     7261 tcaaccacgg cctgctcgcc gccaccgcgg ccgccggcgt cgtcctgctg tggctggtcg
     7321 ccggccacgc ggtggcccgc tccggcctgg agacctccta cactcacggc gcgaagtccc
     7381 tgcaggcgct caacgaggcc cggatcggct cactccaggc ccgtggcgac gagaacctcg
     7441 ccatggtcgc ccggggcgcc gtcctcggga agaacggcga cgacgcctac gagaccggct
     7501 accgcgacgg catgggccgg ctcgtcggcg gcagccaggg cccggcccgc ccggacaccc
     7561 tgctggagcg cgcccgggcg ctcgccgacg acgccgaggg acgcgatccg gtcgaggccg
     7621 ccgtcaagga cgtccgcgag tggcagcagc gccacggcca ggcacgcgcc ctcgccgacg
     7681 accgcggcga ctacgacgac gccctgcgca aggtgatcgg cgacaaggac agcaccggcg
     7741 cgtccttcga ccgggtggac accgaactgc agcgcgcgat cgcccacgag caggccgagt
     7801 tccggcagga ggccgacgac gggcgcggcg cgttctcggg cctcgccgcc ggagcggccg
     7861 tgctgaccgt cctcggcgcc gccggtgccg tcctcggcgt gggccgcagg ctgtcggagt
     7921 accggtgaga ccggtacggg aggacgaggg ggaggcggtg cgcatggcag gggcccggac
     7981 ggggaagcgg atgcgggccg gaccggcggc ggtggcggcc gccgtgtgcg cgctggccgc
     8041 ggcggccgcg gccgtgctgc ccacgggcgg cgcacccgcg caggaccggc ccgcacggac
     8101 cgccgcaccg gccgcacccg cggcgcccgc cccgggcgcc gccgcggcac ccgcgcagtg
     8161 caccgacccg gaggcgagtc tgcggcccgc gggcggggcc gacggagcgg ccgtgcagcg
     8221 catcaaggcc cgcggccggc tgatcgcggg cgtcgaccag aacagctacc gctggggcta
     8281 ccgcaacccc gccgacggcg agctcagcgg cttcgacatc gacctcgtcc gggccgtcgc
     8341 caaggacatc ctcggcgacc ccggcaaggt cacctatctc gcgatcccca cgagccggcg
     8401 catatccgcc ctgcagacgg gcaaggtgga catcgtcgcc cgcacgatga ccatcacgtg
     8461 cgaacggatc aaacaagtgg cgttctccac ggcctacttc gagtccgggc agcaggtgat
     8521 ggtccccaag gggtcaccgg tgaccgcgtt cgacgactca ctgaagggga agaaggtctg
     8581 tacggcggag ggttccacgg ccgagatcaa ggtgcgggaa gagccgcacg gctccaccct
     8641 gctgacggtc cccaaccagc tcgactgcct ggtgcggctc cagctcggcg aggtcgacgc
     8701 cgtggtcaac gacagggccc tggcggccgg ccaggcggcg caggacccgt ccgtgcagct
     8761 cgtcggaaag ccgttcacca ccgaaccgta cggcgtggcg atgaacctcg cggacacgga
     8821 cctggtacgc cgggtcaaca aggtgctgga ggactaccgc gcgggcggcg ccggaagcct
     8881 ctggatgaag gcgtacgaca agtggctcgc cgccgacctg aagggcatca ccgccccgcc
     8941 ggcgcccaag taccgggact gacggcgggc cggggagcac ggccgtaacg gacacgcccg
     9001 cggcgcccgc cgcggacagg agagagggga tcgatggcgg tcgcggagcc caccgggccg
     9061 gccttgaccc gcgaggaggt ggaccgtgcg ctggccaggc tcggcgcgga gcacgaggcc
     9121 gtcgaatcct cgctgctcgc cctccaggac catgcggggc ggcgcctgct ggagggggcg
     9181 gagctcaccg gcgagaccag gagccggtgg gcggccgccg aggccctcat cgggcagctg
     9241 tgggcgtact tcgacgccta caccgcggcc ctgaccgccg cccgcgagct gcgcgcccgc
     9301 cgccgctggc ccacccaggg cgagctgtcc gagctcaccg agctgctgcg cggctccggc
     9361 atcaccctgc ccggccacgg cacggccgcg ctcggcacgg cgggcctccc ggcgggcgcg
     9421 gtgggcacgg cgggcatgac gggcatgacg gcgcgcctca gcgagcagct gagcctgcag
     9481 gagctgctgg accggatgaa cggctggtac gcccgggccc tcgacgtcgt cgtgatcgcc
     9541 gacgccgtgt ggtccgcgct gcccgcccgc atcgacctgc tcgccgccga gctcgggcgc
     9601 acccgctccc tcgcccactc ggtgggcgtc cggcccggcg agcacccctc cggtgacgac
     9661 ctggaacaga tcacccggga actggccgcg ctgcgggaag aggtgatatc cgatccggtc
     9721 gccttctggg ccggctcctc gcccagctcg gccccgggcg gcggccgccc ggacaccacg
     9781 cgctacgacc gcgccgcgcg ggccctggag gacgtccgcc gggaggtcga ggcggtgctg
     9841 gacgtccggc aggacgccga gcggcggctg atgcgcgtgc gcgacgtcct ctcgcgcgcg
     9901 gaccgcacgc tgaacgaggc ccggcaggcg cgcgtcgagg tcctgtcgaa gatcgccgcg
     9961 tccgtggtgc ccgcggtctc gggcccgccg acggccctct acgagcagct ggcggccgcc
    10021 gccgagcacc gcaggcacgc ccggtggcac cggctctcgc cgctcctgga gggcctggag
    10081 cagcgctcgg aggaggagct gctgcgcgcc cgcgagtcgc tgacggcggt gacggccccg
    10141 ctggcggtcc gcgccgagct gcgcggccgc ctggacgcgt acaaggcgaa gaccgcccgg
    10201 cacggcctgg cggaggactc cttgctcatc gagcggtacg acgcggcgcg gcgcatgctg
    10261 tggagcgcgc cgtgcgatct ggtggccgcc gaacaggcgg tcctgcgcta tcagcaggcg
    10321 ctggccgaga cgctgtcggc ggcggcgccg ggcaccgggg agcggcccac ggggcggagg
    10381 ggggaagcgt gagcgaggc
//
