LOCUS       NZ_CP040752            10873 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces rectiverticillatus strain B15-08 chromosome, complete
            genome.
ACCESSION   NZ_CP040752
VERSION     NZ_CP040752.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces rectiverticillatus
  ORGANISM  Streptomyces rectiverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7679243)
  AUTHORS   Park,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAY-2019) Laboratory of Bioorganic Chemistry, NIDDK,
            NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: DEC-2018
            Assembly Method                   :: HGAP v. Dec-2018
            Assembly Name                     :: DDK_LBC_B15-08
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013394065.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:49:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,642
            CDSs (total)                      :: 6,543
            Genes (coding)                    :: 6,394
            CDSs (with protein)               :: 6,394
            Genes (RNA)                       :: 99
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 55 of 149
            Pseudo Genes (incomplete)         :: 125 of 149
            Pseudo Genes (internal stop)      :: 12 of 149
            Pseudo Genes (multiple problems)  :: 41 of 149
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:46:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1613083
            Orig. end                         :: 1623956
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040752.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from LBC, NIDDK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10873
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="18"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10873
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10873
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5873](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5873
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(96..899)
                     /locus_tag="FGW37_RS06755"
                     /old_locus_tag="FGW37_06865"
     CDS             complement(96..899)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989150.1"
                     /locus_tag="FGW37_RS06755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06865"
                     /product="hypothetical protein"
                     /protein_id="WP_179080222.1"
                     /transl_table=11
                     /translation="MSDAAQPSAAEVRAAAEAVKAALDRHLDAVERRSGEDDPAVYAAF
                     NELAATAEAYDELLYDSYDEVTPFEIPGDDTLPAYAGPEEPSALSLLIRRDYAVVEPQR
                     LLAQAQRVADLDPDADAPAGPAGAAAVGNVGGSVHAALGVIFGEYEPDEIASRHKEFGL
                     EEGDSTLWVTASDEPAEPGEWLSAPFEQADPQRVICRFDVSAVFDEDLDGDDDDSDDDG
                     DDGDDGDDDGIDDDGIDDDVMDDDAVDGAPGSGAGGGAPPSSTKP"
     misc_feature    898..916
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.44"
                     /tool="antismash"
     gene            947..1135
                     /locus_tag="FGW37_RS06760"
                     /old_locus_tag="FGW37_06870"
     CDS             947..1135
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135970.1"
                     /locus_tag="FGW37_RS06760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06870"
                     /product="DUF5703 family protein"
                     /protein_id="WP_058045136.1"
                     /transl_table=11
                     /translation="MPEYEFCDVYVPRGVSRGAATRLLTDHAEYGHWELDRLRLYPDGS
                     RKVRLRRRIIRQVRATW"
     gene            complement(1208..2125)
                     /locus_tag="FGW37_RS06765"
                     /old_locus_tag="FGW37_06875"
     CDS             complement(1208..2125)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014628619.1"
                     /locus_tag="FGW37_RS06765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06875"
                     /product="chaplin"
                     /protein_id="WP_179080223.1"
                     /transl_table=11
                     /translation="MRQVTKKGLITAAAASGVLAAVTGSYAQASSGAGGHAANSPGVAS
                     GNTVQVPVHVPVNACGNTVNVIGALNPASGNTCANGGHHGGGHHQGGGHGGKGNGGGNH
                     GHGGNGAHGASTDSPGVASGNTIQVPVEVPVNACGNSVNVVGVGNHTTGNKCANVGGGD
                     GHEWPGHPGNPGHPGKPGHPGGHDGTHKPPHHNPPGGDHGHKPPTDHSSDHHKPGGHTP
                     GKDKPADHTPAGHKPARTDAAHTPAPEVKAEHKAAPAAPTGPAAKAVELAHTGAGQLGM
                     AGAASAGLLLGGAVIYRRARAGQN"
     gene            complement(2281..2514)
                     /locus_tag="FGW37_RS06770"
                     /old_locus_tag="FGW37_06880"
     CDS             complement(2281..2514)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135972.1"
                     /locus_tag="FGW37_RS06770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06880"
                     /product="chaplin"
                     /protein_id="WP_179080224.1"
                     /transl_table=11
                     /translation="MIKKVVASAAVTGGLVLAGAGLAAADSGAQGAAVNSPGVISGNVI
                     QAPVHVPVNACGNSINIVGLLNPTFGNTCVNS"
     misc_feature    complement(2632..2646)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.06"
                     /tool="antismash"
     gene            complement(2656..3999)
                     /locus_tag="FGW37_RS06775"
                     /old_locus_tag="FGW37_06885"
     CDS             complement(2656..3999)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103705.1"
                     /locus_tag="FGW37_RS06775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06885"
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="WP_179080225.1"
                     /transl_table=11
                     /translation="MSESKPAGAGAGKGGGGGEDEVVDLCRDLIRIDTSNYGDHSGPGE
                     RAAAEYVAEKLAEVGLEPQIFESHKGRASTVARIEGEDPSRPALLIHGHTDVVPANAAD
                     WTHHPFAGEIADGCLWGRGAVDMKDMDAMTLAVVRDRMRTGRKPPRDVVLAFLADEEAG
                     GVYGARHLVDKHPGLFEGVTEAIGEVGGFSFTVNENLRLYLIETAQKGMHWMRLTVDGT
                     AGHGSMTNKDNAITELCEAVGRLGRHEFPVRMTKTVRSFLDELSDALGTPLDPEDMETT
                     LAKLGGIAKMIGTTLRNTAAPTMLGAGYKVNVIPGQATAHVDGRFLPGYEEEFLADLDR
                     ILGPRVRREDVHADKALETSFDGKLVDAMQSALKAEDPIARAVPYMLSGGTDAKSFDDL
                     GIRCFGFAPLQLPPELDFAGMFHGVDERVPLEGLKFGARVLDRFLDQC"
     tRNA            4234..4318
                     /anticodon=(pos:1617350..1617352,aa:Leu,seq:gag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="FGW37_RS06780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="FGW37_06890"
                     /product="tRNA-Leu"
     gene            4234..4318
                     /locus_tag="FGW37_RS06780"
                     /old_locus_tag="FGW37_06890"
     gene            4534..5004
                     /locus_tag="FGW37_RS06785"
                     /old_locus_tag="FGW37_06895"
     CDS             4534..5004
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FGW37_RS06785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FGW37_06895"
                     /product="hypothetical protein"
                     /protein_id="WP_179080226.1"
                     /transl_table=11
                     /translation="MTAEPNQGGAPIPSPRELHVCMGLNSCQGLDVSGEATMAGTGTCA
                     TVQHVCHGEGECRGQGGCGYAGGDYAQFHPGEQECRYNGSCASPINKSRVFSAGPLKGR
                     SVWKQARRLFEARMYAAGKAFGPSPGEGIDDDCLPQYDDYGPHDVPGAGAGA"
     gene            5001..5873
                     /locus_tag="FGW37_RS06790"
                     /old_locus_tag="FGW37_06900"
     CDS             5001..5873
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF003818.1"
                     /locus_tag="FGW37_RS06790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06900"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_218650573.1"
                     /sec_met_domain="DUF692 (E-value: 9.6e-95, bitscore: 315.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEARRAVTAPAPPGARTGPSGRPGFGLGLRSPHLPYIRAHRPPV
                     GFFEIISENFLYSQGARRRSLDEIADAYPLVLHGVSLSIGSTDPLDHDYLHRLKRLADD
                     VGALWVSDHVCWTGVLGLNTHDLLPLPFTEESLAHVVRRVRIVQDVLERPLVLENPSSY
                     VGFRASTLTEWEFLARMADEADCGLLLDVNNVHVSAFNHDFDPVEYLRALPHERVVQMH
                     LAGHTHYGSHIIDTHDAPVAEPVWELYRLAVELTGGGVPTLLERDDKLPAFPELLAELD
                     TARAVAGGG"
     gene            5863..6678
                     /locus_tag="FGW37_RS06795"
                     /old_locus_tag="FGW37_06905"
     CDS             5863..6678
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021364.4"
                     /locus_tag="FGW37_RS06795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06905"
                     /product="DNA-binding domain-containing protein"
                     /protein_id="WP_179080227.1"
                     /transl_table=11
                     /translation="MADEPEDGLAAVQRLMQAAILDPYGTGPRPPEEVFTGSSGLTARE
                     RLGVYRNGYRLRLLGTMRDLHPGAVKLLGQEIFDQFALDYLDARPPRSPTLTRLDAGFA
                     GHLRRTRPDTAPGTSREAWIDLLIDVVRYERAFTEVLDGPGPEETCEPANGRHTGRHTA
                     CEPGPAPGLTLLRTCAPVHLYVAAVRRGEDPAPPEPRAAFLALARRDYRVMAHELAPAA
                     HRVLDALVRGVPRREALDGTPPGTARAWLADWTARHLLVTCPNHLPRTE"
     gene            6681..8075
                     /locus_tag="FGW37_RS06800"
                     /old_locus_tag="FGW37_06910"
     CDS             6681..8075
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024306.4"
                     /locus_tag="FGW37_RS06800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06910"
                     /product="ferritin-like protein"
                     /protein_id="WP_179080228.1"
                     /transl_table=11
                     /translation="MNSTPSLAVTKPRSGRIETLDELSAHLCAAAYVELSTVPMYLYAA
                     YSMKTRGYSQWALGKSAQSDLIGVVIEEMQHMALARNVLVAIGRGDDFRVYAEKSVPTY
                     PAPMAHRIPELMLSLRRLSSAQVQTFMDVELPESEQKPAEAVHVVDYHSLGEFYKYIED
                     GITYLSTPAAGKEQIKWADLAANNLWQLQYHRGYWNQNGGAQQPLLVTDEKTALAALKV
                     IVEQGEGAPHDRGHIDPIYPPPLIGEHRRTEDSHYTKFVRIRHGVDGVGVVKDDNGQEK
                     YTIDSPEVIWPVIDNPTIEQVNDVPVRRLMVLSNAAYCYVLALLDKIYLTRTTVDGTQS
                     FRPDERYGYERGFIAAMQGVLYPIADLLMRTPFKDGDLKDKSVGTVNAGPPFQHHAFTV
                     RTASMKTGQKKGKASIRQFWKPQEDLAALCREVTAFYPELGGDDGVERQIRLLPDFELE
                     VPPAEG"
     gene            complement(8104..8889)
                     /gene="ddaH"
                     /locus_tag="FGW37_RS06805"
                     /old_locus_tag="FGW37_06915"
     CDS             complement(8104..8889)
                     /EC_number="3.5.3.18"
                     /GO_function="GO:0016403 - dimethylargininase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000052 - citrulline metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ddaH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575413.1"
                     /locus_tag="FGW37_RS06805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06915"
                     /product="dimethylargininase"
                     /protein_id="WP_179080229.1"
                     /transl_table=11
                     /translation="MPGITALVRRPGPRLAEGLVTHLARTPVDPALALRQWHGYTATLR
                     DHGWRTVEVPPADDCPDAVFVEDAMVVFRNVAVVARSGAPSRRAEAAAAEQVAAELGLS
                     LNRIREPGTLDGGDVLKTGDTVYVGRGGRTNAEGVRQLRAVLEPLGARVVPVPVSKVLH
                     LKSAVTALPDGTVIGYEPLVGTRSLFPRFLPVPEEPGAHVVLLGGDRLLLSAGAPRTAD
                     LLADLGYTPVPVDIGEFEKLEGCVTCLSVRLRGIPLRGA"
     gene            8947..9357
                     /locus_tag="FGW37_RS06810"
                     /old_locus_tag="FGW37_06920"
     CDS             8947..9357
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641496.1"
                     /locus_tag="FGW37_RS06810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_06920"
                     /product="(2Fe-2S) ferredoxin domain-containing protein"
                     /protein_id="WP_179080230.1"
                     /transl_table=11
                     /translation="MITNHSRRPKPATASAPCRVTVCRGCCCGDPRKVPGVDHAGQIPR
                     LRKALGDAAQVRASECLDVCDQANVVVVQPSAAGRAAGGRPVWLGLVNDDDVLADVADW
                     IRAGGPGLAEPPGVLDLYAFTVSRRVGQGVEE"
     misc_feature    complement(9465..9474)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    9688..9703
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.27"
                     /tool="antismash"
ORIGIN
        1 cgacccggct gcgggcgctg ctgcaggccc agggccgccc gtccgagtga ggtcgccctg
       61 ttccgggccc gggcatccgc cgggcccgga gcgggtcagg gcttcgtgga cgagggcggc
      121 gcaccgccgc cggccccgct ccccggggcc ccgtccacgg catcgtcgtc catgacgtcg
      181 tcgtcgatgc cgtcatcgtc gatgccgtcg tcgtcgccat catcgccgtc gtcgccgtcg
      241 tcatcactgt cgtcgtcatc gccgtccagg tcctcgtcga agaccgcgct gacgtcgaag
      301 cggcagatca cccgctgcgg gtcggcctgc tcgaagggcg ccgacagcca ctcccccggc
      361 tcggcgggct cgtccgatgc ggtgacccag agcgtggagt cgccttcctc caggccgaat
      421 tccttgtgcc gcgaggcgat ctcgtccggc tcgtactcac cgaagatcac accgagcgcg
      481 gcgtgcacgc tgccgcccac gttgcccacg gcggccgccc ccgcgggccc ggccggtgcg
      541 tcggcgtcgg gatcgaggtc ggccacgcgc tgggcctggg cgaggagccg ctgcggctcg
      601 accaccgcat agtccctgcg gatcaggagg ctgagtgcgc tcggctcctc cgggcccgcg
      661 taggcgggca gggtgtcgtc cccggggatc tcgaaggggg tgacctcgtc gtaggagtcg
      721 tagagcagct cgtcgtacgc ctcggctgtc gcggccagct cgttgaacgc ggcgtagacg
      781 gccgggtcgt cctcccccga ccggcgttcg acggcgtcga ggtggcggtc cagagcggct
      841 ttgaccgcct cggcggcggc gcgtacctcg gcagcggatg gctgcgcagc atcagacata
      901 gtgcagacgc tatccgcacc gggcccgttc ccgcacaata gatgcgatgc cggaatacga
      961 attctgtgat gtgtatgtgc cgcggggggt ctcccggggt gccgccacac gcctgctgac
     1021 cgaccacgcc gagtacggac actgggagtt ggaccgactg cgcctctacc ccgacggcag
     1081 ccgcaaggtg cggctgcgcc gcaggatcat ccgccaggtg cgcgccacct ggtgacacgc
     1141 agacggagcg ggtcccgcgt cgcgggaccc gctccgtgct gtgcgaaccg ctaccggatg
     1201 atccgggtca gttctgcccg gcacgcgcgc ggcggtagat gaccgcgccg ccgagcagca
     1261 gaccggcgct ggcggcgccg gccatgccca gctggcccgc gccggtgtgc gcgagctcga
     1321 cggccttggc cgccggaccg gtgggcgcgg cgggggccgc cttgtgctcg gccttcacct
     1381 cgggggcggg ggtgtgcgcg gcgtccgtcc gcgcgggctt gtgcccggcg ggggtgtggt
     1441 cggccggctt gtccttgccc ggggtgtgac cgcccggctt gtggtggtcc gacgagtggt
     1501 ccgtcggcgg cttgtggccg tggtccccac cgggcgggtt gtggtgcggc ggcttgtggg
     1561 tgccgtcgtg cccgccgggg tgaccgggct tgcccgggtg accgggattg cccgggtggc
     1621 ccggccactc gtgaccgtcg cccccgccca cgttggcgca cttgttgccc gtggtgtggt
     1681 tgcccacgcc gacgacgttg acgctgttgc cgcaggcgtt gaccggcacc tcgaccggca
     1741 cctggatggt gttgcccgag gccacaccgg gcgagtcggt ggaggcaccg tgggcgccgt
     1801 taccgccgtg cccgtggttc ccgccgccgt tgcccttgcc gccgtgcccg ccaccctggt
     1861 ggtgtccgcc accgtggtgt ccgccgttgg cgcacgtgtt gcccgaggcc gggttgagcg
     1921 ccccgatcac gttcaccgtg ttgccgcagg cgttcaccgg cacgtggacc gggacctgga
     1981 cggtgttgcc cgaggccaca ccgggcgagt tcgccgcgtg gcctccggcc ccggacgacg
     2041 cctgggcgta gctgccggtc acggccgcga gtacgccact cgccgccgct gcagtgatca
     2101 ggcccttctt agtgacctgt cgcatgagtc ctgcctctct gcttgcgcta tacggataca
     2161 cgccagcaat agggacaaag tccccacatg ctcacgtgtc gaaagcccgg gcggctccgg
     2221 agcgcacgca agtcactccg gagccgccca tgtcagaccc ttacgggttg aggcacgacg
     2281 tcagctgttg acgcaggtgt tgccaaacgt ggggttgagc agcccgacga tgttgatcga
     2341 gttgccgcag gcgttcacgg gcacgtggac cggagcctgg atgacgttgc cggagatcac
     2401 gccgggcgag ttcacggcgg ccccctgggc tccggagtcc gcagcggcca ggccagcacc
     2461 cgcgagcacg agaccaccgg taacggccgc ggaagcgacg accttcttga tcatggattc
     2521 ctccttgttg gcaatgcggt cccagccgcg gaccgcacac ctgtaacgac gaggaggtaa
     2581 tcgggctacg caaccctcag atcattcact cgttacggtt aactcggcac aaatttacgg
     2641 aatttaggcc cggtttcagc actgatcgag gaaccggtcg agaacgcgtg cgccgaactt
     2701 caggccttcc aggggcactc gttcgtcgac gccgtggaac atccccgcga aatccagctc
     2761 cggcggtagc tgcagcggcg cgaaaccgaa gcaccggatg cccaggtcgt cgaaggactt
     2821 cgcgtccgtg ccgcccgaga gcatgtacgg cacggcgcgg gcgatcgggt cctccgcctt
     2881 cagggccgac tgcatggcgt cgacgagctt gccgtcgaag ctcgtctcca gcgccttgtc
     2941 cgcgtgcacg tcctcgcgcc ggacccgcgg gccgaggatg cggtcgaggt cggcgaggaa
     3001 ctcctcctcg taccccggca ggaaccttcc gtcaacgtgt gccgtggcct gtcccgggat
     3061 gacgttgacc ttgtatcccg cgcccagcat ggtcggggcg gcggtgttgc gcagcgtggt
     3121 gccgatcatc ttggcgatgc cgccgagctt ggcgagcgtc gtctccatgt cctcggggtc
     3181 gagcggcgtg ccgagggcgt cggagagctc gtcgaggaag gagcgcacgg tcttggtcat
     3241 ccggaccggg aactcatgcc gccccagccg gccgaccgcc tcgcacagct ccgtgatcgc
     3301 gttgtccttg ttggtcatcg agccgtggcc ggcggtgccg tcgaccgtga gccgcatcca
     3361 gtgcatgccc ttctgggccg tctcgatcag atagagccgc aggttctcgt tgaccgtgaa
     3421 ggagaagccg ccgacctcgc cgatcgcctc ggtcacgccc tcgaagagcc cggggtgctt
     3481 gtccaccagg tggcgcgcgc cgtagacgcc gcccgcctcc tcgtccgcga ggaaggcgag
     3541 caccacgtcg cgcgggggct tgcggcccgt gcgcatgcgg tcgcggacga ccgcgagggt
     3601 catcgcgtcc atgtccttca tgtccaccgc gccacggccc cacaggcacc cgtccgcgat
     3661 ctcgcccgcg aaggggtgat gggtccagtc ggcggcgttg gccggcacga cgtcggtgtg
     3721 gccgtggatg agcagcgccg gccgtgaggg gtcctcgccc tcgatccgcg ccacggtcga
     3781 ggcgcgcccc ttgtgggact cgaagatctg cggttcgagc ccgacctcgg cgagcttctc
     3841 cgccacgtac tcggcggcgg cgcgctcgcc cggcccggag tggtcgccgt agttgctggt
     3901 gtcgatccgg atcagatcgc ggcagaggtc gacgacctcg tcctcgccgc ccccgccgcc
     3961 cttgcccgcc ccggccccgg ccggcttcga ctcgctcacg ctgcctcctc ctggttcgct
     4021 gccgtgcgcc gccccgctga gggcggccca cggcgtgggt cctccgccat cctctctctc
     4081 cggccgccgc agcccaaggc cgcaatgctg ccgacatccg cccgccacac cggccgggag
     4141 ccgctcgacc ggccacgtga tcgagcaccc ccagatcttt ggtattgttt tcctcgtcgg
     4201 aagggcaacg gcccggaagg cgaaaaacac ctagtccggg tggcggaatg gcagacgcgc
     4261 tagcttgagg tgctagtgcc ctttatcggg cgtgggggtt caagtccccc ctcggacaca
     4321 ggctaaggcc ccagttgaac tggggccttt ttgctttccc ggttgctttc ccggtcgctt
     4381 tccggctgct tgccccggcc ggggccccgg gccggcgctc gtggccggat gtcccgcatg
     4441 gcccgttctc tccctcccgc gctcgcggtc cgccctgcca ccgtgtgggg tcgcacatct
     4501 ccaccacgcg gtgagcgaaa ggagcgagtg acggtgactg ctgaaccgaa ccagggcggc
     4561 gcccccatcc cgtccccccg ggaactccac gtctgcatgg gcctgaactc ctgccagggg
     4621 ctcgacgtca gcggcgaggc cacgatggcg ggcacgggta cctgcgcgac cgtgcagcac
     4681 gtgtgccacg gcgagggcga gtgccgggga cagggcgggt gcggctacgc cgggggcgac
     4741 tacgcgcagt tccaccccgg cgagcaggag tgccgctaca acggcagctg cgccagcccg
     4801 atcaacaaga gccgtgtgtt ctccgcgggc ccgctgaagg gcaggagcgt ctggaagcag
     4861 gcccgcaggc tcttcgaggc ccggatgtac gcggccggca aggcgttcgg cccgtctccc
     4921 ggcgagggga tcgacgacga ctgcctgcct cagtacgacg actacggccc ccatgatgtg
     4981 cccggcgcgg gggcgggggc gtgaccgagg cgcggcgggc ggtgacggcc cccgccccgc
     5041 ccggtgcccg gacgggcccc tccgggcgcc ccggcttcgg cctcgggctg cgcagccccc
     5101 acctccccta catccgcgcg caccggccgc cggtcggatt cttcgagatc atctcggaga
     5161 acttcctgta ctcgcagggc gcccggcgcc gatcgctgga cgagatcgcg gacgcgtatc
     5221 ccctcgtgct gcacggcgtg tccctgtcca tcggcagcac ggacccgctc gaccacgact
     5281 atctgcaccg gctcaagcgc ctcgccgacg acgtgggcgc gctgtgggtg tccgaccacg
     5341 tctgctggac cggcgtcctg ggcctcaaca cccacgacct gctgccgctg cccttcaccg
     5401 aggagtcgct ggcccacgtc gtccggcgcg tccgcatcgt gcaggacgtc ctggagcgcc
     5461 cgctcgtgct ggagaacccc agcagctacg tgggcttccg cgcctccacc ctcaccgagt
     5521 gggagtttct ggcgcgcatg gccgacgagg cggactgcgg actgctgctc gacgtcaaca
     5581 acgtccacgt ctccgcgttc aaccacgact tcgacccggt ggagtacctg cgcgccctgc
     5641 cgcacgagcg cgtggtccag atgcacctgg ccgggcacac ccactacggc agccacatca
     5701 tcgacaccca cgacgccccc gtggccgagc cggtgtggga gctgtaccgg ctggccgtgg
     5761 agctgacggg cggcggcgtt ccgacgctcc tggagcggga cgacaagctg ccggccttcc
     5821 ccgagctgct ggccgagctc gacacggcgc gggcggtggc cggtggcgga tgagccggag
     5881 gacggcctgg cggcggtgca gcggctgatg caggccgcga tcctggaccc gtacggaacg
     5941 ggcccgcgcc ctcccgagga ggtgttcacc ggctcctccg ggctcaccgc gcgcgaacgg
     6001 ctgggcgtct accggaacgg ctaccggctg cggctgctgg gcaccatgcg cgatctgcac
     6061 ccgggggcgg tcaagctgct cggccaggag atcttcgacc agttcgcact ggactacctg
     6121 gacgcccggc cgccgcgttc ccccaccctg acccgtctcg acgcgggctt cgccggccac
     6181 ctgcggcgca cccgcccgga caccgctccc ggcacgtccc gtgaggcgtg gatcgacctg
     6241 ctcatcgacg tggtgcggta cgagcgggcg ttcaccgagg tcctggacgg gccgggtccg
     6301 gaggaaacct gcgaacccgc caacggcagg cacaccggca gacacaccgc ctgcgaaccc
     6361 ggcccggccc ccgggctgac gctgctgcgc acctgcgccc ccgtacacct ctatgtggca
     6421 gcggtacgca ggggcgagga ccccgcgccc ccggagccgc gggcggcctt cctggcactg
     6481 gcgcgtcgcg actacagggt gatggcccac gagctcgccc cggccgccca ccgggttctc
     6541 gacgcgctgg tgcgcggggt cccccggcgg gaggcgctgg acggaacgcc gcccggtacg
     6601 gcgcgcgcgt ggctggcgga ctggacggcc cggcacctgc tcgtgacctg cccgaaccac
     6661 cttccccgaa cggagtagcc atgaacagca cgccgtcgct cgcggtcacg aagccccgga
     6721 gcgggaggat cgagacgctg gacgaactga gtgcgcactt gtgtgcggcc gcgtacgtgg
     6781 aactctccac cgtgccgatg tacctgtacg cggcgtactc gatgaagacg cgcggctatt
     6841 cgcagtgggc cctggggaag tcggcccaga gcgatctgat cggcgtggtc atcgaagaga
     6901 tgcagcacat ggccctcgcc cggaacgtgc tggtcgcgat cggccgcggc gacgacttcc
     6961 gggtctacgc ggagaagtcc gtgcccacgt atccggcgcc gatggctcac cggattcccg
     7021 agctgatgct gagtctgcgg cgcttgtcca gcgcgcaggt ccagacgttc atggacgtcg
     7081 agctcccgga gtcggagcag aagccggccg aggcggtcca tgtcgtcgat taccactcac
     7141 tcggggagtt ctacaagtac atcgaggacg gcatcaccta cctgagcacg ccggcggcag
     7201 ggaaggaaca gatcaaatgg gcggacctcg ccgcgaacaa cctgtggcag ctccagtacc
     7261 accgcgggta ctggaaccag aacgggggcg cgcagcaacc gttgctggtc accgacgaga
     7321 agaccgcgct cgccgcgctg aaggtcatcg tcgagcaggg tgagggcgca ccgcacgaca
     7381 ggggccacat cgacccgatc taccctcccc ctctgatcgg ggagcaccgc aggacggagg
     7441 attcccacta caccaagttc gtccgcatcc ggcacggagt ggacggcgtc ggtgtcgtca
     7501 aggacgacaa cggccaggag aaatacacca tcgacagccc cgaggtcatt tggccggtca
     7561 tcgacaaccc gacgatcgag caggtcaacg acgtcccggt gcggaggttg atggtcctgt
     7621 ccaacgcggc ctactgctac gtgctggcgc tgctcgacaa gatctacctg acgcgcacga
     7681 ccgtggacgg gacccagtcg ttccggccgg acgaacggta cggctacgag cggggcttca
     7741 tcgccgccat gcagggcgtg ctgtacccga tcgccgacct cctgatgcgc acgccgttca
     7801 aggacggcga cctcaaggac aagagcgtgg ggaccgtgaa cgccgggccg cccttccagc
     7861 accacgcgtt cacggtccgg acggcgtcga tgaagaccgg tcagaagaag ggaaaggcct
     7921 ccatccggca gttctggaag ccgcaggagg acctggccgc cctctgtcgt gaggtgaccg
     7981 cgttctatcc ggagctcggc ggcgacgacg gcgtcgagcg gcagatccgt ctgctgcccg
     8041 acttcgagct ggaggtaccg cccgccgagg gctgagccgg ccgagggctg agccggccgc
     8101 gcttcaggcg ccgcgcagcg gtatcccccg cagccggacg gacaggcacg tcacgcatcc
     8161 ctccagcttc tcgaactcgc cgatgtccac cgggaccggc gtgtacccga ggtccgcgag
     8221 caggtccgcg gtcctcgggg cgccggccga gaggaggagg cggtcgcctc ccaggaggac
     8281 gacgtgggct cccggctcct cggggacggg aaggaagcgg gggaagaggg accgcgtgcc
     8341 gaccaggggc tcgtagccga tgaccgtgcc gtcggggagg gcggtgaccg ccgacttcag
     8401 gtgcaggacc ttgctgacgg gcacgggtac gacgcgtgcc cccagcggtt ccaggacggc
     8461 ccgcagttgg cgcacgccct ccgcgttggt gcggccgccc cggcctacgt agacggtgtc
     8521 gccggtcttg aggacgtcgc cgccgtcgag ggtgccgggt tcgcggatgc ggttgaggga
     8581 gaggccgagt tccgcggcga cctgttccgc ggccgccgcc tcggcgcggc gcgagggggc
     8641 tccggagcgt gccacgacgg cgacgttgcg gaagacgacc atggcgtcct cgacgaagac
     8701 ggcgtccggg cagtcgtcgg cgggcgggac ctcgacggtc cgccagccgt ggtcgcgcag
     8761 ggtcgccgtg tagccgtgcc actgccgcag ggcgagggcg gggtccacgg gcgtgcgcgc
     8821 gaggtgggtc accaggcctt cggcgaggcg ggggccgggg cggcgtacga gagcggtgat
     8881 gccgggcacg tgggcttcct ctccatgacg gccggaccgc aggggcccgt gcgtatcatc
     8941 tggctgatga tcaccaacca ttcccgccgc ccgaagccgg caaccgcctc cgccccctgc
     9001 cgcgtcaccg tctgccgcgg ctgctgctgc ggcgatccgc ggaaggtgcc gggggtcgac
     9061 cacgccgggc agatcccgcg gctgcggaag gcgctgggcg atgccgccca ggtgcgggcc
     9121 tccgagtgcc tggacgtctg cgaccaggcg aacgtggtgg tcgtgcagcc gtcggcggcg
     9181 gggcgggcgg ccggcgggcg gcccgtgtgg ctcgggctcg tcaacgacga cgacgtgctc
     9241 gcggacgtgg cggactggat acgggcgggc gggccggggc tggcggagcc gcccggggtg
     9301 ctggacctgt acgcgttcac ggtgtcgcgg cgggtggggc agggcgtgga ggagtaggcc
     9361 cgcgggccgc tcctccttac gctcctccgg ccgccccgcc tccgtcctcc ccgccctccg
     9421 gccgctccgc cctccgttca gtccccgcgc ggtcctgccg ccgaggccgc cttctccagc
     9481 tggaacgcct cgttgccgag cccgatgccg gcgtgcaccc cggggcgcag gtacttgagg
     9541 acgatgccgt agccgatgcc ggcgaggacg gccgcgccga tggtgccggg caggatccag
     9601 cgcaggggcg atccggggtc ggcgccgagc aggacgtcga agtccttgac cgcgtacacg
     9661 gcgatgacga cgagggcggc cccggcgacg ccggaggcga tcaggcgcgg cgcctgcgtg
     9721 cgcgcggcac cgcgccggac gaagaaggcg atgacggcgg cggacgcggc ggccatcagc
     9781 acgatgatgc cgagggcgcc gacgttgccg ctccaggtga acaggcgcag gacgggtgcg
     9841 gtgggatcgt cgtgcgggcg gccgtcggtc acggcgaaga ggaggacggc gatcagcgag
     9901 acgccgctct gcagcaggga gccgtaggcc ggggcgccgc tcgcgcggga ggtgcggccg
     9961 acggcggcgg gcagcaggcc ctcgcggccc atggcgaaag cgtagcgggc gacgacgttg
    10021 tggaagctga gcatcgcggc gaacatgccg gtcacgtaga agacgtgcat gacgtcggtg
    10081 aaggtgctgc cgagccgctc ctcggtgagg gcgaagagca ggttcgggcc cttctcctgg
    10141 gcgaggccga cgatggcgtc cgggccggcg gcgacgctga gggcccagga gctcagggcg
    10201 aagaagagcg cgacgaagcc gacggcgagg aaggtgacgc gggcgacgac gacgttcggg
    10261 cggctggtct cctcggcgta gacggcggcc tgttcgaagc cgacgaaggc cgcgatggtg
    10321 aagcacaggg cggtgccgag gccgcccccg ccgagggtgg tggggtcgaa ggcgtggagg
    10381 gagacgccct gcgggcccgg gtcggcgagg ccggcgaagt cgaaggccac gaccatcacg
    10441 cattcgatga gcagcaggat cccgaggacc ttggcgctga ggtctatctt cagccagccg
    10501 aggacgccga cgacgaggac ggcggcgagg gcggggaccc accaggcgac ggcgaggccg
    10561 aggtgtctgt cgagcaggcc ggagagctcg tagccgaaga tgccgtatat cccgaactgc
    10621 atggggctgt aggcgacgag ggcgacgaca gaggcggcgg cgccggccgt gccgccgagg
    10681 ccgcgggcga tgtaggcgta gaaggcgccg gcgttgtgga cgtggcggct catttcggcg
    10741 tagccgaagc tgaagagggt cagcaccacg ccgaggatga cgaagagcag gggctggccg
    10801 acgatggcca tcgtcccgta ggtggtgggc atgacgcccg ccgtcaccat caggggcgcg
    10861 ctggcggcga cga
//
