LOCUS       NZ_CP040752            20927 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces rectiverticillatus strain B15-08 chromosome, complete
            genome.
ACCESSION   NZ_CP040752
VERSION     NZ_CP040752.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces rectiverticillatus
  ORGANISM  Streptomyces rectiverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7679243)
  AUTHORS   Park,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAY-2019) Laboratory of Bioorganic Chemistry, NIDDK,
            NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: DEC-2018
            Assembly Method                   :: HGAP v. Dec-2018
            Assembly Name                     :: DDK_LBC_B15-08
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013394065.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:49:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,642
            CDSs (total)                      :: 6,543
            Genes (coding)                    :: 6,394
            CDSs (with protein)               :: 6,394
            Genes (RNA)                       :: 99
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 55 of 149
            Pseudo Genes (incomplete)         :: 125 of 149
            Pseudo Genes (internal stop)      :: 12 of 149
            Pseudo Genes (multiple problems)  :: 41 of 149
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:46:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 956643
            Orig. end                         :: 977570
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040752.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from LBC, NIDDK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20927
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20927
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20927
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10927](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10927
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    597..606
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            729..1259
                     /locus_tag="FGW37_RS03770"
                     /old_locus_tag="FGW37_03840"
     CDS             729..1259
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FGW37_RS03770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FGW37_03840"
                     /product="hypothetical protein"
                     /protein_id="WP_179079746.1"
                     /transl_table=11
                     /translation="MPRSTARGPAGAGPVSAADVLRARLTVHEHPLMVLEPGGTTAAVA
                     LPEGLAVQLLGPDDPALPSAAALGPLAFSRDGTADRLAARIRAGLTVAAAAVRGDTALC
                     SGMHQPVVAVTELVGIGTLPAVRRQGPWASRSPRPSSPTRGRGARRPSSSPPATTTWSG
                     STPGQASAARARH"
     gene            complement(1332..2273)
                     /locus_tag="FGW37_RS03775"
                     /old_locus_tag="FGW37_03845"
     CDS             complement(1332..2273)
                     /EC_number="3.5.1.28"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891208.1"
                     /locus_tag="FGW37_RS03775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03845"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_179079747.1"
                     /transl_table=11
                     /translation="MAWYPGATKMELQPESDDQPAIRPTQFILHSVGAPWTARRLYEFW
                     RDSTNLESHFGLGYGGDLAQYIGTQTRADANYRANLRPDGSGAVSIETASNLEHTDPWT
                     DRQVDRLVEVGVWLHQYHGLPLRVCRSWDEPGYGYHRLFSQWSTGGTACPGDARVGQFH
                     DVVFPAIVARASDRPADPLPGGAAPRTLGEYTDAQTALVPGTWTTLSVNGRTLISGAKA
                     YTATVFLTVTVPAGSTLQGRFYHQRADGSRWNGPIVERIATVGASFVDFTHHGSVSEGE
                     TVRFEACYDPPAPGVRDPGTVSTSRARGLYWT"
     misc_feature    complement(1896..1898)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2326..2341
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.89"
                     /tool="antismash"
     misc_feature    complement(2327..2340)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.73"
                     /tool="antismash"
     misc_feature    2441..2450
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.04"
                     /tool="antismash"
     gene            2466..3227
                     /locus_tag="FGW37_RS03780"
                     /old_locus_tag="FGW37_03850"
     CDS             2466..3227
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953108.1"
                     /locus_tag="FGW37_RS03780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03850"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_179079748.1"
                     /transl_table=11
                     /translation="MSRSFDDLVAEAEAAPMAGWDFSWLDGRATEERPSWGYQRTMSER
                     LAFADAALDIQTGGGEVLAGARKLPRTMVATESWPPNVAKATRLLHPLGAVVVADADEP
                     PLPFADEAFDLVTSRHPATVWWEEIARVLRPGGTYLAQHVGPASAFELVEYFLGPQPEE
                     VRRRRHPDDERREAEAAGLGVVDLRAETLRMEFRDVGAVIYFLRKVIWMVPGFTVGQYR
                     DRLRELHERITAEGPFVAHSARFLIEARKPV"
     gene            3347..4534
                     /locus_tag="FGW37_RS03785"
                     /old_locus_tag="FGW37_03855"
     CDS             3347..4534
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006351075.1"
                     /locus_tag="FGW37_RS03785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03855"
                     /product="isoaspartyl peptidase/L-asparaginase"
                     /protein_id="WP_246430253.1"
                     /transl_table=11
                     /translation="MRSRLWILPVLTALVAVAVALPALSQPSARPEGAAAAAGPGRGAA
                     PRPEATDVVLAVHGGAGTALRREDTDARTEKAYRDGLADALRAGRKVLRDGGGSVAAVE
                     AAVRSLEDNALFNAGKGAVFTEDAGHELDASVMRGSDLAAGAVAGVRHVRNPVSAARLV
                     MERTPHVLLAGEGADDFAVRNGLPAVTQDYYWTQARWDSLMKAKERSRGGTSPSASGKS
                     VDGRAVDGRAVDGKTVDDRAVGSEAVGESAMGTVGAVAVDRKHDLAAATSTGGMTNKMA
                     GRVGDSPLVGAGTYAKNATVAASATGHGEVFIRGAATSTLSHLIEFGGRDVATAAHEVV
                     HERLTRLGGTGGMIALGPDGVLAAPHSSEGMLYGYLTAGGEIVTKVFPDESRTGR"
     misc_feature    3539..3541
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4539..5939)
                     /locus_tag="FGW37_RS03790"
                     /old_locus_tag="FGW37_03860"
     CDS             complement(4539..5939)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="FGW37_RS03790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03860"
                     /product="cytochrome P450"
                     /protein_id="WP_179079750.1"
                     /sec_met_domain="p450 (E-value: 2.5e-61, bitscore: 206.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTRRHDRTPADPGLRAGRAPGARPLAGHLPALYRSPLGFLGALP
                     RYGDLVEVRIGRRPVFMLCHPDLVRRVLTDDRTYDREGPTYQRSRRAMGNGLATCPQAE
                     HRTQRRLMQPAFGPDHLARYATVMRRTIGEAMDGWRHGQQVDLGGELFALATRTAVRAL
                     FDADLPPAEGRELHEALDAFLKGIYRQTLLPWAAALPTPGNRRYGRALAHWQAYTARLV
                     GTRRARPGTGGSGDVPKDVLSHLLSTRLPDGAPVAGDAVHDQCTALVLAGSETTASALA
                     WSCHLLSHHRDVAEELYAEAHGVLRGRTATQEDLPGLPLTGRVVTEALRLYPPAWLIPR
                     VTTVETELAGRCLPAGNMVVFSPYIIHRRGDLYPEPGRFRPGRWAEEDVPADGPAADRN
                     ASLRAYVPFGLGAHRCIGESFALTEATMALATIAARWRLQAVPGAAVRPAARAVLAPEY
                     LPMYLYAR"
     gene            complement(6128..6853)
                     /locus_tag="FGW37_RS03795"
                     /old_locus_tag="FGW37_03865"
     CDS             complement(6128..6853)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072643.1"
                     /locus_tag="FGW37_RS03795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03865"
                     /product="hypothetical protein"
                     /protein_id="WP_179079751.1"
                     /transl_table=11
                     /translation="MNDDVRNIVLGLVASGISATAGWFVRTLLWRRQLRRKQIFFGLPA
                     GSECLLVVNQDPSANGWGVARHDAFALLEISALIKECGAHADIVVHDAARQGIGVRTEF
                     CVGGPVSNRRTEAHLRSLLPGVAVANGHGGPDAGALTVGGETYRVDKGTAEYVLLARVT
                     GPGGSRPVFLASGQRSVTNQAAIRYLAGHHRQLAHRYGLDGTFCLLLKVVNSDAYGPDM
                     VELVSDITAAATTAPSPAR"
     gene            6947..7453
                     /locus_tag="FGW37_RS03800"
                     /old_locus_tag="FGW37_03870"
     CDS             6947..7453
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118011.1"
                     /locus_tag="FGW37_RS03800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03870"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_179079752.1"
                     /transl_table=11
                     /translation="MKIESETAGQDPEAARDPRTPGIRSGAQRKRDVLERLRRELDIWV
                     ASAGADGVPCLVPLWFLWDGEAIWMSTRPANPTGRNLRDGGRARLALGHTRDVVLIDGD
                     VETYGAQEVPAAAADAFARHSGWDPRKEGGAYAYFKVMPRAVQAWHEEPELRGRHLMRD
                     GEWLV"
     gene            complement(7619..8428)
                     /locus_tag="FGW37_RS03805"
                     /old_locus_tag="FGW37_03875"
     CDS             complement(7619..8428)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004991116.1"
                     /locus_tag="FGW37_RS03805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03875"
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_179079753.1"
                     /transl_table=11
                     /translation="MFYCAFKAVVLVPLLRWLFRPRVEGLGRVPQHGAAIVAGNHQSFT
                     DQFLMGVTLRRRITFLAKSEYFTGRGLKGRLAAAFFRGLGAIPVDRSGRGAGQAAVEEG
                     VKVLGRGELLGIFPEGTRSHDGRLYKGKVGVAEMAIRSGAPVVPCAMIGTFEAQPAGRR
                     LPRLVPVTVRFGEPLDFSRYAGMADQRHVLRAVTDEIMYAILKLSEQEYVDVYAVDARA
                     RLSAHGSGPARAEVLGSTRFAPGPDRTRGDHAAAAGHAAPGEGRTAA"
     misc_feature    8504..8517
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            complement(8528..9361)
                     /locus_tag="FGW37_RS03810"
                     /old_locus_tag="FGW37_03880"
     CDS             complement(8528..9361)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (68-210). E-value: 2.1e-24. Score:
                     77.4. Matches aSDomain: nrpspksdomains_FGW37_RS03810_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004955102.1"
                     /locus_tag="FGW37_RS03810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03880"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_246430254.1"
                     /transl_table=11
                     /translation="MSKEANEEATRSYYDSGDVDAFYDAVWGGEDIHTGIYTRPGEAIA
                     EASRRTVERVADRLAGSLGPGAAVIDLGSGYGGTARRLAERFGCRVVALNLSAAQNERH
                     RAVNAERGLAGLVEVLTGSFHDIPFPDGHFDAVCSLEAFCHSSDRPKVLSEAARVLKPG
                     GALAFTDLMAAEDTSAEVLRPAVSRLGVDALATVSFYRDRLARLGLSGVGFDDHSGQLV
                     NHYVRLTEETAARAAELGGRIGAAYLGHLQENLPVWVDAARRGHLQWGVLHGRRP"
     aSDomain        complement(8732..9157)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FGW37_RS03810_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.10E-24"
                     /label="FGW37_RS03810_oMT.1"
                     /locus_tag="FGW37_RS03810"
                     /protein_end="210"
                     /protein_start="68"
                     /score="77.4"
                     /tool="antismash"
                     /translation="VIDLGSGYGGTARRLAERFGCRVVALNLSAAQNERHRAVNAERGL
                     AGLVEVLTGSFHDIPFPDGHFDAVCSLEAFCHSSDRPKVLSEAARVLKPGGALAFTDLM
                     AAEDTSAEVLRPAVSRLGVDALATVSFYRDRLARLGLS"
     gene            complement(9454..9849)
                     /locus_tag="FGW37_RS03815"
                     /old_locus_tag="FGW37_03885"
     CDS             complement(9454..9849)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836966.1"
                     /locus_tag="FGW37_RS03815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03885"
                     /product="hypothetical protein"
                     /protein_id="WP_179079754.1"
                     /transl_table=11
                     /translation="MKPWLLTDIERAVRSSWGADTCTPEYRSRWTPDNPARDQCGVTAM
                     VLNDLLGGELIRGEVRVGGLQTDFHWWNRLGEGVEIDLTREQFSPEEVVTGGLVIPRPP
                     EIKRLREEYELLRERVLEKLRTGVAVP"
     gene            10001..10927
                     /locus_tag="FGW37_RS03820"
                     /old_locus_tag="FGW37_03890"
     CDS             10001..10927
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145757.1"
                     /locus_tag="FGW37_RS03820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03890"
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_179079755.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.5e-27, bitscore:
                     93.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 6.4e-08,
                     bitscore: 30.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTWNKALDVAGVHDRRLRADYTRQRDLVARFRRHAYVAVRLLL
                     PGATVPHVIAMTAFMHHTDNVLDSGSTLAERTSAYVTWERDVREALAGGRADHPVIRPV
                     LHTVAARPGLAEAVEAFLKTAVADLDFTGFATEGAYQDYVDAYSLPAFMLVAGVLDPGT
                     DPGAYRAACRSYIDGSQRLDFVNDLAEDLEGGRLALPRETLEQHGVSRGDLESARETPA
                     VRALLAGQLRRARHDLLAARRLAGLTSPVDRSFVRAMVELEVLTADAAAAKGFGLLRGP
                     ARPPAGAALRMFLRECARARTARRRAL"
     gene            11081..11383
                     /locus_tag="FGW37_RS03825"
                     /old_locus_tag="FGW37_03895"
     CDS             11081..11383
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004953812.1"
                     /locus_tag="FGW37_RS03825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03895"
                     /product="hypothetical protein"
                     /protein_id="WP_058041490.1"
                     /transl_table=11
                     /translation="MDEEEDRRLRAIAPEISHTTIGLMRTIVGLEPAERVPEEALKVAD
                     RVLAKHGTDGLRVLVMSLSGWMAVGIENVAHLKGQTNEAIIDDIELTCLEANPDG"
     gene            11477..12460
                     /locus_tag="FGW37_RS03830"
                     /old_locus_tag="FGW37_03900"
     CDS             11477..12460
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (25-310). E-value:
                     8.6e-30. Score: 96.1. Matches aSDomain:
                     nrpspksdomains_FGW37_RS03830_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712409.1"
                     /locus_tag="FGW37_RS03830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03900"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_179079756.1"
                     /sec_met_domain="PF00561 (E-value: 3.1e-23, bitscore: 81.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.8e-18, bitscore:
                     65.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSVEHRFVEVNGVTLHIAEQGRGPLVVLLHGFPECWYSWRHQF
                     GPLAAAGYRVVAVDQRGYGRSEQPDDIGAYSVLHLAGDVIALIHALGEESAVVVGHDWG
                     APVAWTTALLRPDVVRGVAGLSVPPQPHGPAAPLPALRSLLGDGFYQLYFQEPGVADAE
                     LARDPATSFRRILFSGSGDSPQTDPPRPWVIPSGSTLLDTMAEPEELPGWFTEEDVDVF
                     VREFSAHGDRAFTGGLNWYRNIDRNWELLAPFHGLRIEVPALYVGGDRDLVRAFPGVDR
                     LLASLEETVPGLRRSVTLPGCGHWTQQERPEEVNAELLEFLSSLNA"
     aSDomain        11552..12406
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FGW37_RS03830_Abhydrolase_1.1"
                     /evalue="8.60E-30"
                     /label="FGW37_RS03830_Abhydrolase_1.1"
                     /locus_tag="FGW37_RS03830"
                     /protein_end="310"
                     /protein_start="25"
                     /score="96.1"
                     /tool="antismash"
                     /translation="PLVVLLHGFPECWYSWRHQFGPLAAAGYRVVAVDQRGYGRSEQPD
                     DIGAYSVLHLAGDVIALIHALGEESAVVVGHDWGAPVAWTTALLRPDVVRGVAGLSVPP
                     QPHGPAAPLPALRSLLGDGFYQLYFQEPGVADAELARDPATSFRRILFSGSGDSPQTDP
                     PRPWVIPSGSTLLDTMAEPEELPGWFTEEDVDVFVREFSAHGDRAFTGGLNWYRNIDRN
                     WELLAPFHGLRIEVPALYVGGDRDLVRAFPGVDRLLASLEETVPGLRRSVTLPGCGHWT
                     QQER"
     gene            12477..13529
                     /locus_tag="FGW37_RS03835"
                     /old_locus_tag="FGW37_03905"
     CDS             12477..13529
                     /NRPS_PKS="Domain: PKS_ER (19-270). E-value: 3.6e-13.
                     Score: 41.3. Matches aSDomain:
                     nrpspksdomains_FGW37_RS03835_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999412.1"
                     /locus_tag="FGW37_RS03835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03905"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_179079757.1"
                     /sec_met_domain="ADH_N (E-value: 7.8e-24, bitscore: 82.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 8.7e-21, bitscore:
                     72.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTMLAGRLDLRSGAFAVEEIPVPRPGPGQVRVKVEAAGICLSD
                     VHLIDGSLKPVHTRADKITLGHETAGVVDALGPGVPAEWTVGRRVLLQAGERCGTCRPC
                     ERFTTPCLRLLTRGVDYDGGWAEYALAGHHTLVALPDDLPFEQAAIIPDAVSTPWSAIT
                     LTGRARPARPAGVWGTGGLGAHAVQLLRLVGAAPVIAVDPLAAARQRALDFGADLALDP
                     ADPGLRARILAATDGHGLDLALDTAGVPAVREQAVGCLAADGRLVLVGLGPGPLTIGNS
                     IAFSVRHQQILGHYGSEPGHVDELVTLARLGRLDLGRSISGTLPLAEAAAGVERLRKKE
                     GDPIRLVLTP"
     aSDomain        12534..13286
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FGW37_RS03835_PKS_ER.1"
                     /evalue="3.60E-13"
                     /label="FGW37_RS03835_PKS_ER.1"
                     /locus_tag="FGW37_RS03835"
                     /protein_end="270"
                     /protein_start="19"
                     /score="41.3"
                     /tool="antismash"
                     /translation="EEIPVPRPGPGQVRVKVEAAGICLSDVHLIDGSLKPVHTRADKIT
                     LGHETAGVVDALGPGVPAEWTVGRRVLLQAGERCGTCRPCERFTTPCLRLLTRGVDYDG
                     GWAEYALAGHHTLVALPDDLPFEQAAIIPDAVSTPWSAITLTGRARPARPAGVWGTGGL
                     GAHAVQLLRLVGAAPVIAVDPLAAARQRALDFGADLALDPADPGLRARILAATDGHGLD
                     LALDTAGVPAVREQAVGCLAADGRLVLVG"
     gene            complement(13539..14159)
                     /locus_tag="FGW37_RS03840"
                     /old_locus_tag="FGW37_03910"
     CDS             complement(13539..14159)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FGW37_RS03840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FGW37_03910"
                     /product="hypothetical protein"
                     /protein_id="WP_179079758.1"
                     /transl_table=11
                     /translation="MKLRPTTLAPALGCAALLALGTPGTAAAHGDTIHFAVGGEQQGGH
                     VRTVATWENDGDPVDEPVAGTLTATGPEGRTAGPWQLVAAEGGKGAYTTRESLPQGTWK
                     VVVHCGFPDLGHGEGRVTVAAGTAEAGHGPAPAGSAAAPERSAPAGPAAARREAAPPEA
                     EEAPAASSRTGLVAGVCAAGAVAVAAAVFLRRAGRSGKAAVTK"
     gene            complement(14296..16284)
                     /locus_tag="FGW37_RS33815"
                     /old_locus_tag="FGW37_03915"
     CDS             complement(14296..16284)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262356.1"
                     /locus_tag="FGW37_RS33815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03915"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_281394671.1"
                     /transl_table=11
                     /translation="MILTAAAAAAAAGIAFGVMGTGSATSTPGPQPEAASAPAAQPVHK
                     KPPAPLTSTPRADKQRGLVYDGLKPAPKGDRCVGVYSVSRAGLCTHGPDAPPKGVDITK
                     DTPPVAGKTAAPSSLTGDGGQAPSASEALGGAPSVIDARRGGVAAAAAAPGPGAPANPQ
                     AGSGSKVVCEGDGSSGNRVQVLYVHASGRDRFGQYAASFKQWAAETDVIYNASAKETGG
                     ERHVRYVTEADCTASVLNVEVSAGALQEFGAMNNALAAKGFNRRDRKYMIFADAQVYCG
                     IGTFNGDERPGPDNLSNFGPSYGRTDSGCWGGSTPAHELGHNLGAVNNSAPHTSKAAHC
                     VDEWDIMCYSDAPHYPRMQVLCPERTGDQRLDCGHDDYFHTSPKPGSYLATHWNIADNR
                     FLMAGGGTTNPGPGPTPTRTPDPTRPPAAGPDAQVSQVTPNSAVVSWPKVPSATGYDLL
                     VNGKKTAGVQDTVVRLTGLAPGTSYKVAVAARGADGKASAPGRAASFRTLSADGGSPTR
                     PGTAYVMVNGLTGEALDLWGGSTADGTVAIAYQRHGYANQQWSFENAGGGALRVKSVQS
                     GKCLQLGGGDRAVAGQYVAQQPCRDTAAQKWRLNAAGGGSYVLQPEGSSLVLGISKRSY
                     YGGRLLELQQKNDQGYQNWTLSKAASS"
     gene            complement(16418..18109)
                     /locus_tag="FGW37_RS03850"
                     /old_locus_tag="FGW37_03920"
     CDS             complement(16418..18109)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888934.1"
                     /locus_tag="FGW37_RS03850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03920"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_179079759.1"
                     /transl_table=11
                     /translation="MNLDSTAGVVEAARGGDDAAQDQLVAACLPLVYNIVGRALNGHAD
                     VDDVVQETMIRMVGGLHALRDPEGFRSWLVAITMNQIRSHWRKELKDRKDAPSGGLQEV
                     GEAAAPEPDFVEWSIIRLGLQGQRRQAAQATRWLDGDDQVVMALWWQEAAGELSRAEVA
                     AALGRSPQYTAVRVQRTKAQLETARVVVRALATDPRCPELTGALGDWDGAPSPLWRKRI
                     ARHARGCAECGGHWSALVPAEGLLAGLGLVPVGAALLARVTAAPPGGPMAACAATAPGS
                     ASAGAPEPSADSAPPGEPAPGTPADLGRLARRAVVAAGVVAVVVVGGTLGGPHLFNAAP
                     ESARPQAPGGPVQVVPVTAGDPTPAGPDRTDATAVARSDTDGRTPVRASAPAAPPAPAP
                     AATPAAAKSPSGPAAEKPAAPSAAPDPAGATPRRTPPPAAPGAGPAQEVVRIVNTERAK
                     AGCGPVRFSAELVAVAQRHTDDTASRTPAGQWSAFARRAAVPGHHWSSYGVNAATGQSS
                     ASAVVSVWMDDPRHRRTILNCAYTELGVGVSFAYDGPRWMQVFAAR"
     misc_feature    complement(18179..18193)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.64"
                     /tool="antismash"
     misc_feature    18210..18219
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.63"
                     /tool="antismash"
     gene            complement(18241..18801)
                     /locus_tag="FGW37_RS03855"
                     /old_locus_tag="FGW37_03925"
     CDS             complement(18241..18801)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018106297.1"
                     /locus_tag="FGW37_RS03855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03925"
                     /product="hypothetical protein"
                     /protein_id="WP_179079760.1"
                     /transl_table=11
                     /translation="MLKMNALPDVPRWAVLAAHAVPLVTLPSGLWRIALVAGLPVAAPD
                     GDMTVWGALYVLSLTAVSEALALLTLGLVRPWGEVVPRWIPLLGGRRVRPLAAVVPALL
                     GATALAALAVWFVCAPYVNPEQAIWQGTAAQDALLAVCYVPLLAWPPLLTAVTIAYYRR
                     RTGRRTARNGTADGAADRALARV"
     gene            complement(18890..19288)
                     /locus_tag="FGW37_RS03860"
                     /old_locus_tag="FGW37_03930"
     CDS             complement(18890..19288)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018562697.1"
                     /locus_tag="FGW37_RS03860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03930"
                     /product="VOC family protein"
                     /protein_id="WP_179079761.1"
                     /transl_table=11
                     /translation="MLHHLELWVPDLQRAAKSFGWLLGALGYTPHQRWEHGRSWRLGAF
                     YLVVEQSPALAAGTHERCRPGMNHVAFPVESRAAVDALVEEAPEHGWRLMFPGEHPFAG
                     GPAHYAAYLENEDGFEAELVAAAAEDAP"
     gene            complement(19335..20561)
                     /locus_tag="FGW37_RS03865"
                     /old_locus_tag="FGW37_03935"
     CDS             complement(19335..20561)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492557.1"
                     /locus_tag="FGW37_RS03865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_03935"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_179079762.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.9e-15, bitscore:
                     54.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.9e-25, bitscore:
                     87.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1e-51, bitscore:
                     173.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEFTMELNEDQRGVRDWIHGFAAEVMRPAAAEWDEREEFPWPVV
                     QEAARIGLYSLDFYAQQFFDPTGLGIPMAMEELFWGDAGLGLAITGTGLAAIGVLTNGT
                     EEQIGTWLPQMYGDAHDVKIAAFCSSEPDAGSDVSAMRTRAVYDEAKDEWVLNGTKTWA
                     TNGGIANVHIVVAVVDPELGARGHASFIVPPDTPGLSQGQKFKKHGIRASHTAEVVLDG
                     VRLPGHCLLGGKDKLDERLARARERVRTGGARTHNAAMATFEASRPTVGAQAVGIARAA
                     YEVALDYAQTRHQFGRPVIDNQGVAFQLADMRTRIDAARLLVWRASWMATAGKPFTAAE
                     GSMSKLFAGETAKAVTAQAMQILGGNGYTREYPVERMHRDAAIYTIFEGTSEIQRLVIA
                     RTISDVPIR"
     misc_feature    complement(20714..20730)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.4"
                     /tool="antismash"
ORIGIN
        1 tcgcgcgcga cgcgggcgaa gcggtaccac tcggtctgct cgaaccagtc cgcggcgacc
       61 tcgttcgccc tgagcatcgc gagggcgcgc gggaagtgac ggccgtacat ctcgccggcg
      121 tcgacctgcg ggagcacttc cccgaagtag gagcgccggg gcgtcgcggc gatgccgccg
      181 ttgacgagcg agccgccgcc caccccacgc cccacgtaca cccccatctg accgaagttc
      241 acgcggtcga ggacgccggc gtacggctgg accgggcggt tgacgacgtc gagccagagg
      301 aaggaggcga cgggcgcctc ggtgcggttc ttgaaccagg tggagcgccg gtccgggtcg
      361 agcatcccgc agaagacctt gccgtccggc ccgggccggt tccacagctg ccccatctcc
      421 agcatcagcg tcccgacgcc tgcctccccc agccgcagcg cggtgacggc cgccccgtag
      481 cccgtgccga ccaccacggc cggtacgaag gcgccgctgc cgaccggacc ggcggcggac
      541 ggccgcggtc cggccgcggc cgtgatcgtg gtcgcgcccg tgagggaggc ggcaccgaag
      601 gcggcccagc ccagcagacg gcggcgcgac aggggggagc ttccggcccc ggtggcgtga
      661 tccggtctct tcgacaccac acccaaggta gcagtgtgtc aggagacgct tacagggtgt
      721 gcgtgaccgt gccgcgcagc accgcccggg gcccggcggg cgccgggccg gtgagcgccg
      781 ccgacgtgct gcgggccagg ctgaccgtgc acgaacaccc cctgatggtg ctcgaaccgg
      841 gcggcaccac ggccgcggtg gcgctgcccg agggcctggc cgtgcagctg ctcggcccgg
      901 atgaccccgc gctgccgagt gcggcggccc tcggcccgct cgccttctcc cgggacggca
      961 cggcggaccg tctggcggcg cgcatccgcg cgggcctgac ggtggccgcc gcggccgtcc
     1021 gcggggacac ggccctgtgt tcgggcatgc accagcccgt cgtcgcggtc accgagctgg
     1081 tcggcatcgg gacgctgccc gccgtgcgcc ggcagggccc ctgggcctcg cggtcaccgc
     1141 ggccctcgtc gccgacgcgc ggtcgcgggg cgcgcagacc gtcttcctct ccaccggcga
     1201 cgacgacgtg gtccggatcc actcccgggc aggcttccgc cgcgcgggca cggcactgat
     1261 cgcggagccc gccgagcccc ggggcgccgc aggcctgacc cgggacgccg cgaccagctc
     1321 ccgcctccgg gtcaggtcca gtacaagccg cgcgcccgcg aggtggagac cgtgcccggg
     1381 tcgcgtacac ccggcgcggg cgggtcgtag cacgcctcga agcggacggt ctccccttcg
     1441 gagacggagc cgtggtgggt gaagtcgacg aaggacgcgc ccaccgtcgc gatgcgctcg
     1501 acgatcgggc cgttccagcg ggagccgtcc gcccgctggt ggtagaagcg cccctggagc
     1561 gtgctgcccg cagggaccgt cacggtcagg aagaccgtgg ccgtgtacgc cttcgcgccg
     1621 ctgatcaagg tccggccgtt gaccgagagc gtcgtccacg taccggggac gagcgcggtc
     1681 tgcgcgtcgg tgtactcgcc gagcgtccgc ggcgccgccc cgcccggcag cgggtcggcg
     1741 ggccggtcgg aggcccgggc cacgatggcg gggaagacca cgtcgtggaa ctgccccacg
     1801 cgggcgtcgc ccgggcaggc cgtgccgccc gtggaccact gcgagaacag ccggtggtag
     1861 ccgtagcccg gttcgtccca ggagcggcag acccgtaacg gcaggccgtg gtactggtgc
     1921 agccacaccc cgacctcgac gagtctgtcg acctgccggt cggtccacgg gtcggtgtgc
     1981 tccaggttgg aggcggtctc gatgctcacc gccccgctgc cgtccgggcg caggttggcc
     2041 cggtagttgg cgtcggcgcg ggtctgggtg ccgatgtact gcgcgaggtc gcctccgtag
     2101 ccgaggccga agtgcgactc gaggttggta ctgtcgcgcc agaactcgta gaggcggcgc
     2161 gcggtccacg gcgcgccgac gctgtgcagg atgaactggg tggggcggat cgccggctga
     2221 tcgtccgact ccggctggag ctccatcttc gtggcgcccg ggtaccaggc catcacgact
     2281 cctcggggct ggggggtggg ggtgcgcgcc gcaccgcacg gcgacacgca cgtctgttcg
     2341 cggtatgccc gttcccatgc cgcgcgccac cgggaacgag tgcctccggt ggtgaatgcc
     2401 gtcccggaag tcccgggaac taaatcccgg ggactattga tgttctttgc ggtattactt
     2461 ctgatatgtc acgaagcttt gacgacctgg tggccgaggc cgaggccgcc cccatggccg
     2521 gctgggactt ctcctggctg gacggccggg ccaccgagga gcgaccctcc tggggctatc
     2581 agcgcaccat gagcgagcgc ctggccttcg cggacgctgc cctcgacatc cagacgggcg
     2641 gcggggaggt cctcgccggg gcgcggaagc tgccccgcac gatggtggcc acggagtcct
     2701 ggccgcccaa cgtcgccaag gcgacgaggc tgctgcaccc cctcggggcg gtcgtggtcg
     2761 ccgatgccga cgagcctccc ctgcccttcg ccgacgaggc gttcgacctc gtgaccagcc
     2821 gtcacccggc gaccgtgtgg tgggaggaga tcgcccgggt gctgcggccg ggcggcacgt
     2881 acctcgcgca gcacgtgggc ccggccagcg ccttcgagct ggtcgagtac ttcctgggcc
     2941 cccagccgga ggaggtgcgg cgcaggcgcc accccgacga cgagcggcgg gaggcggagg
     3001 ccgcggggct cggcgtcgtc gatctgcgcg ccgagaccct gcggatggag ttccgcgacg
     3061 tcggcgcggt gatctacttc ctgcggaagg tgatctggat ggtccccggc ttcaccgtcg
     3121 gccagtaccg cgaccggctg cgcgaactgc acgaacgcat cacggccgaa ggtcctttcg
     3181 tcgcccactc ggcgcgcttc ctcatcgagg cccgcaagcc cgtctgaccc gccggctccg
     3241 aaggggtgcg ctcgcacggt ggcgtggaat cggtccttga gctaagaaac gagcgcccca
     3301 tgaagcgagc ccggatcgcg aaagcgaagg agcgaggccc atgcgcatgc gttcgagact
     3361 ctggatcctt cccgtactca ccgccctggt ggcggtcgcg gtggctctgc ccgcactgtc
     3421 acagccgtcg gcccggccgg agggcgccgc ggcggccgcg ggccccggcc gcggggccgc
     3481 tccccggccg gaggcgaccg acgtggtgct ggccgtgcac ggcggcgccg gtacggcgtt
     3541 acggcgggag gacaccgacg cccgcacgga gaaggcttac cgcgacgggc tggccgacgc
     3601 cctgcgcgcc ggccggaagg ttctgcggga cggcggcggc agcgtggccg cggtcgaggc
     3661 ggccgtacgg tcgctggagg acaacgccct gttcaatgcg ggcaaggggg cggtgttcac
     3721 cgaggacgcg gggcacgagc tggacgcgtc ggtcatgcgc ggctcggacc tggcggccgg
     3781 tgccgtggcc ggcgtccgcc acgtgcgcaa ccccgtctcc gccgcccgcc tcgtgatgga
     3841 gcgcacgccg cacgtgctgc tggcgggcga gggcgccgac gacttcgccg tgcgcaacgg
     3901 cctgccggcg gtgacccagg actactactg gacgcaggcg cgctgggaca gcctcatgaa
     3961 ggccaaggag cggagcaggg gcggcacttc gccgtccgcg agcgggaagt ccgtcgatgg
     4021 cagggccgtt gatggcaggg ccgtcgacgg caagaccgtc gatgacaggg ccgtcggcag
     4081 tgaggccgtc ggcgagtccg ccatgggtac ggtcggcgcc gtggccgtcg accgcaagca
     4141 cgacctcgcc gccgcgacct ccacgggcgg aatgaccaac aagatggccg gccgcgtggg
     4201 cgactccccc ctcgtggggg cggggacgta cgcgaagaat gcaacggtgg cggccagtgc
     4261 gaccgggcac ggcgaggtgt tcatccgcgg ggccgccacg tcgaccctct cgcacctgat
     4321 cgagttcggc ggcagggacg tggccactgc cgcccatgaa gtcgtgcacg agcggctcac
     4381 ccggctgggc ggcacgggcg gcatgatcgc actcggcccc gacggggtgc tcgccgcccc
     4441 gcacagcagc gagggcatgc tctacggcta tctgacggcc ggcggcgaga tcgtcacgaa
     4501 ggtgttcccc gacgagtcgc gcaccggccg gtgacggctc agcgcgcgta caggtacatg
     4561 ggcaggtact cgggagcgag cacggccctg gccgccgggc ggacggcggc tccgggaacc
     4621 gcctgcagcc tccagcgggc ggcgatcgtc gccagcgcca tcgtcgcctc ggtcagggcg
     4681 aaggactccc cgatgcagcg atgggcgccg agcccgaacg gcacgtaggc acggagtgat
     4741 gcgttccggt cggctgcagg gccatcggcc ggaacgtcct cctccgccca gcggccgggc
     4801 cggaaccggc cgggttcggg gtagaggtcg ccgcggcggt gaatgatgta cgggctgaac
     4861 accaccatgt tgcccgccgg caggcaccgg cccgccagct ccgtctccac ggtggtcacc
     4921 cgcgggatca gccacgccgg cgggtacagg cgcagggcct cggtgacgac ccgtccggtc
     4981 agcggcagcc cgggcaggtc ctcctgggtg gcggtccgtc cccgcaggac tccgtgggcc
     5041 tcggcgtaga gctcttcggc gacgtcgcgg tggtgcgaca ggaggtggca ggaccaggcg
     5101 agcgcggagg cggtggtctc ggagccggcg aggacgagcg cggtgcactg gtcgtggacg
     5161 gcgtcgccgg cgaccggtgc cccgtcgggc aggcgggtgg agagcaggtg ggagaggacg
     5221 tccttgggaa cgtccccgct gccgccggtc ccggggcgcg cgcggcgggt gccgacgagg
     5281 cgggcggtgt acgcctgcca gtgggccagg gcgcggccgt agcggcggtt gccgggggtg
     5341 ggcagcgcgg cggcccacgg caggagcgtc tgccggtaga tgcccttgag gaaggcgtcc
     5401 agggcctcgt gcagctcccg gccctcggcg ggcggcaggt cggcgtcgaa gagcgcccgc
     5461 accgcggtcc tggtggccag cgcgaacagc tcgccgccga ggtcgacttg ctgtccgtgg
     5521 cgccacccgt ccatggcctc gccgatcgtc cgccgcatga ccgtcgcgta ccgggccagg
     5581 tggtccgggc cgaaggcggg ctgcatcagc cggcgctgcg tccggtgctc ggcctggggg
     5641 caggtcgcca ggccgttgcc catcgcgcgg cgggagcgct ggtacgtggg cccctcccgg
     5701 tcgtaagtcc ggtcgtcggt gaggacccgg cgcacgagat cggggtggca gagcatgaac
     5761 accggccggc ggccgatgcg gacctcgacg aggtcgccgt accggggcag tgcgccgagg
     5821 aagccgagtg gcgacctgta gagggcgggc aggtgccctg ccaggggccg ggcccccggc
     5881 gcgcgacccg cccgcaagcc ggggtccgcg ggcgtccggt cgtggcggcg ggtccccatg
     5941 gacgtgcctc caggatctgc gcccggaatc ctcttccggg cacggcgtcg tcgcggcagc
     6001 agggcacggc caccgtagcg aagccgcccc tgcggaagga accgccgcac cgcccgcacc
     6061 gccggatcgg gtgagcccct cggcggggag cggggagcgg ggctgcagtc atcgggcgcg
     6121 gccgcggtca gcgggcgggg gacggcgcgg tggtggccgc cgcagtgatg tcggagacca
     6181 gttccaccat gtccggtccg tacgcgtccg agttcacgac cttcagcagg aggcagaacg
     6241 tgccgtcgag cccgtaacgg tgggcgagct gtctgtggtg cccggccagg taccgtatgg
     6301 ccgcctggtt ggtgacgctg cgctggccgg aggcgaggaa gaccggccgg ctgccgccgg
     6361 gcccggtcac ccgggcgagc aggacgtact cggccgtccc cttgtccacc cggtacgtct
     6421 cgccgccgac ggtgagcgcg cccgcgtccg gcccgccgtg gccgttggcc accgcgacgc
     6481 cgggcagcag cgaacgcagg tgggcctcgg tgcgccggtt cgacacggga ccgccgacgc
     6541 agaactcggt gcgcacgccg atcccctggc gggcggcgtc gtgcaccacg atgtccgcgt
     6601 gcgccccgca ctccttgatc agcgcggata tctccagcag cgcgaaggcg tcgtgccgcg
     6661 cgacgcccca gccgttcgcg ctcgggtcct ggttgaccac gagcaggcac tccgagcccg
     6721 ccggcaggcc gaagaagatc tgcttgcgcc ggagttggcg ccgccacagc agggtccgga
     6781 cgaaccagcc cgcggtggcg ctgatcccgc tggcgaccag tcccagcacg atgttgcgca
     6841 cgtcgtcgtt catgagcggg cagcctacgg gcccgggccg ggtcggtcga cggccctacg
     6901 gccgcagccc gaggcgcacg ggagaccgcg cgggtagcgt ccgggcatga agatcgaatc
     6961 ggagacggcc gggcaggacc cggaggcggc acgggatccg cggacccccg gcatccgcag
     7021 cggagcgcag cgcaagcggg acgtcctgga gcggctgagg cgggagctgg acatctgggt
     7081 cgcctcggcc ggcgccgacg gggtgccgtg cctggtgccg ttgtggttcc tgtgggacgg
     7141 ggaggcgatc tggatgtcga cccggccggc caacccgacg ggccgcaacc tgcgggacgg
     7201 cggccgggcc cggctcgccc tcgggcacac gcgtgacgtc gtcctcatcg acggcgacgt
     7261 ggagacgtac ggcgcgcagg aggtgccggc cgcggcggcc gacgcattcg cccggcactc
     7321 gggctgggac ccccgcaagg agggtggtgc gtacgcctac ttcaaggtga tgccgcgcgc
     7381 cgtacaggcg tggcacgagg aacccgagct ccgtgggcgt cacttgatgc gcgacggcga
     7441 gtggctcgtc tgagcgacgg gcggtggcgg cttcgcccgg gcggcaggcg gcggcaggcg
     7501 cctctgccgg ccggcgggcg tccctccggt ggcggccggt acaggagggc gctgccggac
     7561 gggccggcgg agcttccgcc ggccgcccgg cgcgcccgtc cccacggatg tgcctctgct
     7621 acgccgcggt gcggccttct ccgggagccg cgtgcccggc cgcagccgcg tggtcgccgc
     7681 gcgtgcggtc cgggccggga gcgaaccgcg tgctccccag gacctcggcg cgggccgggc
     7741 cggagccgtg ggcgctcagc cgggccctgg cgtcgacggc gtacacgtcg acgtactcct
     7801 gctccgacag cttcaggatc gcgtacatga tctcgtcggt gaccgcgcgc agcacgtgcc
     7861 gctggtccgc catgcccgcg tagcgggaga agtccagggg ttcgccgaag cggaccgtga
     7921 cgggcaccag gcgcggcagc cgccggcccg cgggctgggc ctcgaacgtg ccgatcatcg
     7981 cgcacggcac gacgggcgcg ccggagcgga tcgccatctc ggcgacgccg accttgccct
     8041 tgtagagccg tccgtcgtgc gagcgcgtgc cctcggggaa gatgccgagg agttcgccgc
     8101 ggccgagcac cttcacgccc tcctcgacgg cggcctgtcc cgcgccgcgg ccggagcggt
     8161 cgacgggtat cgcgccgagg ccgcggaaga aggctgcggc gagcctgccc ttgaggccgc
     8221 ggccggtgaa gtactccgac ttggcgagga aggtgatccg gcgccggagg gtcacgccca
     8281 tcaggaactg gtcggtgaac gactggtggt tgcccgcgac gatcgccgcg ccgtgctgcg
     8341 ggacccggcc cagcccctcc accctcggcc ggaagagcca ccgcagcagc ggcaccagca
     8401 ccacggcctt gaacgcgcaa tagaacatgc aaacgccctt ctcccagaga cccccgcgcc
     8461 cgggcacgct actcgcgggt atggatcagg gggagaaggc cgattgagcc agatcgtggc
     8521 cggttgatta cggacggcgt ccgtgcagga cgccccactg caggtgtccg cggcgtgcgg
     8581 cgtccaccca tacgggcagg ttctcctgca ggtggccgag gtaggcggcg ccgatgcgcc
     8641 cgccgagctc cgccgcgcgc gccgccgtct cctcggtcag ccgaacataa tggttgacca
     8701 gttggccact gtggtcgtcg aatccgacgc cggacaggcc gaggcgggcg agccggtcgc
     8761 ggtagaagga cacggtggcc agggcgtcca cgccgaggcg ggagacggcc gggcgcagca
     8821 cctccgcgga ggtgtcctcg gcggccatga ggtcggtgaa ggccagcgcg cccccgggct
     8881 tgagcacgcg ggccgcctcg ctcagcacct tcggccggtc actgctgtgg cagaaggcct
     8941 ccagggagca cacggcgtcg aagtggccgt cggggaacgg tatgtcgtgg aaggacccgg
     9001 tgaggacctc gacgagaccg gcgaggccgc gctcggcgtt gacggcgcgg tgccgctcgt
     9061 tctgggcggc gctgaggttg agggcgacga cgcggcagcc gaagcgctcg gcgagccggc
     9121 gggcggtccc cccgtatccg gagccgaggt cgatgacggc ggcgccgggg ccgaggctgc
     9181 cggcgagccg gtccgcgacc cgctcgacgg tgcggcggga ggcctccgct atcgcctcgc
     9241 cggggcgggt gtagatgccg gtgtggatgt cctcgccgcc ccagaccgcg tcgtagaagg
     9301 cgtccacgtc gccggagtcg tagtagctgc gcgtcgcttc ctcattggct tccttgctca
     9361 caggtgctcc tctcgcccgc aggacaggtc gggatcagcc tgacctccgc acggtggcga
     9421 acacagggac gatccggcca tgatcgggcc gtgtcagggc acggccacgc ccgtccgcag
     9481 cttctccagg acgcgctcgc gcaggagctc gtactcctcg cggagacgct tgatctcggg
     9541 cgggcgcggt atgaccaggc cgccggtgac gacctcttca ggggagaact gctcgcgggt
     9601 gaggtcgatc tccacgccct cgccgagccg gttccaccag tggaagtcgg tctgcaggcc
     9661 gccgacgcgg acctcgcccc ggatgagctc gccgcccagc aggtcgttga ggaccatggc
     9721 ggtcaccccg cactggtcgc gcgccggatt gtccggggtc cagcgcgacc ggtactcagg
     9781 ggtgcacgtg tcggcgcccc agctgctgcg gacggcgcgc tcgatgtcgg tgagaagcca
     9841 cggtttcatg ctgcgcatcc tggcagtgac cactgacagt gccggaggaa gaggaggaag
     9901 agagcgtgcg agccgacgca ggcggggtcg gccggcgcac acgacgtaca gtcctccgtg
     9961 gcccgcagcg gccggaacca gccgacggga aaagggatca atgacgagca cgtggaacaa
    10021 ggcgctcgac gtcgccggcg tccatgaccg gcgactgcgc gccgactaca cccggcagcg
    10081 cgacctcgtc gcgcgcttcc ggcgccacgc ctacgtggcc gtccggctgc tgctgcccgg
    10141 tgcgaccgtc ccgcacgtca tcgccatgac cgcgttcatg caccacacgg acaacgtgct
    10201 cgacagcggc agcaccctgg ccgagcgcac ctccgcctac gtcacgtggg agagggacgt
    10261 acgcgaggcc ctggccggcg ggcgcgcgga ccatccggtg atccggccgg tgctccacac
    10321 ggtcgccgcc cgccccgggc tcgccgaagc ggtcgaggcc ttcctgaaga ccgcggtggc
    10381 cgatctcgac ttcaccgggt tcgccacgga aggcgcctac caggactacg tcgacgccta
    10441 ctcgctgccg gcgttcatgc tcgtcgccgg cgtgctcgac ccgggcaccg accccggcgc
    10501 gtaccgtgcg gcctgccgtt cgtacatcga cggcagccag cgcctggact tcgtcaacga
    10561 cctcgccgag gacctggagg gcgggcgcct ggccctcccc cgggagaccc tggagcagca
    10621 cggcgtctcc cgcggcgacc tggagtcggc gcgcgagacc ccggccgtac gggcgctcct
    10681 ggccggtcag ttgcgccgcg cgcgccacga cctgctggcc gcccggcgcc tggccggcct
    10741 cacctcaccg gtcgaccgtt cgttcgtgcg agcgatggtg gagctggaag tgctcaccgc
    10801 ggacgccgcg gcggcgaagg gcttcggcct gctgcggggg cctgcgcgcc ctccggccgg
    10861 cgccgccctg cggatgttcc tccgggagtg cgcccgcgcg cggaccgccc ggcggcgcgc
    10921 cctctgagtg cgttccgagc accgccgggg gcgacttggg gccttcttga ccgggattca
    10981 cccgtagcag cgatcacccg ttggtgttcg ggctgcggtc gccgcgcacg gccacctagg
    11041 gtgcttgcac gtgaccggct gacggacgaa tcgaggacac gtggacgagg aagaggaccg
    11101 gaggctgcgg gcgatcgcac cggagatctc gcacaccacc atcgggctga tgcgcaccat
    11161 cgtcggcctc gaaccggcgg aacgggtccc cgaagaggcg ctcaaggtgg cggaccgggt
    11221 gctcgccaaa cacgggacgg acgggctgcg ggtgctcgtc atgagcctgt cggggtggat
    11281 ggcggtcggc atcgagaacg tcgcgcacct gaagggccag acgaacgagg ccatcatcga
    11341 cgacatcgaa ctgacctgtc tggaggccaa ccccgacggc tgaggcggac cggccgagtg
    11401 gtcaacatct cgtacgccgc ggggaagtcg ccccctactg tggagtacgt cggcgtgacg
    11461 cccccgggag gacaccatga ccagctcggt cgagcaccgc ttcgtcgagg tcaacggagt
    11521 aacgctgcac atcgccgagc aggggcgcgg gcccctggtc gtcctgctgc acggcttccc
    11581 ggagtgctgg tactcctggc ggcaccagtt cgggccgctg gccgcagccg ggtaccgggt
    11641 cgtcgcggtc gatcagcgcg ggtatgggcg cagcgaacag ccggacgaca tcggcgcgta
    11701 cagcgtgctg cacctcgccg gtgacgtgat cgccctgatc cacgcactcg gcgaggagag
    11761 cgcggtggtc gtcgggcacg actggggcgc gccggtcgcc tggaccacgg cgctgctgcg
    11821 gcccgacgtc gtccgcggcg tggccggcct gagcgtgccg ccgcagccgc acggcccggc
    11881 ggcgccgctg ccggcgctgc gctcgttgct cggcgacggt ttctaccagc tctacttcca
    11941 ggaacccggc gtcgccgacg cggagttggc gcgggatccg gcgacgtcgt tccgccggat
    12001 cctgttcagc ggctcgggcg acagcccgca gaccgacccg ccgcgcccgt gggtcatccc
    12061 gtccggcagc acgctcctgg acacgatggc ggagccggag gagctgccgg gctggttcac
    12121 cgaggaggac gtggacgtct tcgtgcgcga gttctccgca cacggcgacc gggccttcac
    12181 cggcggcctg aactggtacc gcaacatcga ccggaactgg gagctcctcg cgcccttcca
    12241 cggcctccgc atcgaggtgc ccgcgctgta cgtggggggc gaccgcgatc tcgtccgggc
    12301 cttccccggc gtggaccggc tgctggcgtc cctggaggag acggtgccgg ggctgcgccg
    12361 cagcgtgacc ctgccgggct gcggtcactg gacgcagcag gagcgcccgg aggaagtcaa
    12421 cgccgagctc ctcgagttcc tgtcgtccct gaacgcgtag ccgggaggcc cctgccatga
    12481 gtgacacgat gctcgccgga aggctcgacc tgcgctccgg cgccttcgcc gtcgaggaga
    12541 tacccgtccc ccggccgggg ccggggcagg tgcgcgtcaa ggtcgaggcc gccggtatct
    12601 gcctgtccga cgtgcacctc atcgacggca gcctcaagcc cgtccacacc cgggccgaca
    12661 agatcacgct cggccacgag accgccggcg tcgtcgacgc cctgggcccc ggcgtgccgg
    12721 cggagtggac cgtgggccgc cgcgtcctgc tgcaggcggg cgagcgctgc ggcacctgcc
    12781 gcccctgcga gcgcttcacc acaccgtgcc tgcgcctgct gacccgcggc gtggactacg
    12841 acggcggctg ggccgagtac gccctcgccg gtcaccacac gctggtcgcc ctccccgacg
    12901 acctgccgtt cgagcaggcc gcgatcatcc cggacgccgt ctccacgccg tggtccgcga
    12961 tcaccctgac gggccgggcc cgccccgcac gcccggcagg cgtgtggggc acgggcggtc
    13021 tcggcgcgca cgccgtgcag ttgctgcgcc tcgtcggggc agcgccggtc atcgccgtcg
    13081 accccctggc agccgcccgg cagcgggcgc tcgacttcgg cgccgacctc gccctcgacc
    13141 ccgccgaccc cggcctgcgg gcgcgcatcc tggcggcgac cgacggccac gggctggacc
    13201 tcgcgctcga cacggccggg gtcccggccg tgcgcgagca ggccgtgggc tgtctggcag
    13261 cggacggccg cctggtcctc gtcggcctcg gccccgggcc gctgacgatc ggcaacagca
    13321 tcgccttcag cgtccggcac cagcagatcc tcgggcacta cggctcggag cccgggcacg
    13381 tcgacgaact ggtcaccctc gcccgcctgg gccgcctcga cctcggccgc tccatcagcg
    13441 ggaccctgcc gctggcggag gccgccgccg gggtcgagcg gctccgcaag aaggaaggcg
    13501 acccgatccg gctggtcctc accccgtgat gccgcccctc acttggtgac ggcggccttc
    13561 cccgagcgcc cggcccgccg caggaacacc gcggcggcaa ccgccacggc gccagccgcg
    13621 cagacgccgg cgacgaggcc cgtacgggag gaggccgcgg gagcctcctc ggcctccggg
    13681 ggcgccgctt cccgccgggc ggccgccgga ccggccggcg cggaccgctc cggcgcggcg
    13741 gcgctcccgg ccggagcagg accgtgcccg gcctccgcgg tcccggccgc gaccgtgacc
    13801 ctcccctccc cgtggccgag gtccgggaag ccgcagtgga cgacgacctt ccatgtgccc
    13861 tgcggcaggc tctcgcgggt ggtgtaggcc cccttcccgc cctcggcggc cacgagctgc
    13921 cacgggcccg cggtgcgccc ctccgggccg gtggccgtca gggtgccggc gacgggctcg
    13981 tcgacgggat ctccgtcgtt ctcccaggtc gccaccgtcc gtacgtggcc gccctgctgc
    14041 tcgcctccga cagcgaagtg gatggtgtcg ccgtgcgcgg cggccgttcc gggcgtgccc
    14101 agggcgagca gggcggcgca cccgagcgcc ggggccaggg tggtggggcg cagcttcatc
    14161 gtggcggttc ctcagggggt gtcgggaggg gcagggcgga aggggccggc gaccgccggt
    14221 ggggggaggg ggagcagcgg tcgccggccc ggtcaggagg gaggccgtca gatggaggcc
    14281 gtcaggaaga agccgtcagg aagaagcagc cttcgacagg gtccagttct ggtatccctg
    14341 gtcgttcttc tgctggagtt cgagcaggcg gccgccgtag tacgagcgct tgctgatgcc
    14401 cagtaccagg gacgagccct cgggctgcag gacgtacgac ccgccaccgg cggcgttcag
    14461 ccgccacttc tgcgcggcgg tgtcccggca gggctgctgg gccacgtact ggccggccac
    14521 ggcccggtct ccgccgccca gttggaggca cttaccgctc tggaccgact tcacgcgcag
    14581 cgcgccgccg ccggcgttct cgaaggacca ctgctggttg gcgtagccgt ggcgctggta
    14641 ggcgatggcg acggtgccgt ccgccgtgga gccgccccac aggtcgaggg cctcaccggt
    14701 gaggccgttg accatcacgt acgcggtgcc cggccgggtc ggcgagccgc cgtcggcgga
    14761 gagggtgcgg aaggacgcgg cgcggcccgg tgcggaggcc ttgccgtcgg cgccgcgcgc
    14821 ggccacggcg accttgtagg aggtgccggg agccaggccc gtgaggcgga cgacggtgtc
    14881 ctgcacgccg gccgtcttct tcccgttgac cagcaggtcg tagccggtgg ccgagggaac
    14941 cttcggccag ctgacgacgg ccgagttcgg ggtgacctgg ctgacctggg cgtcgggccc
    15001 ggccgccggc ggccgcgtcg ggtcgggggt gcgggtcggc gtggggccgg ggccggggtt
    15061 cgtggtgccg ccgcccgcca tcaggaagcg gttatcggcg atgttccagt gggtggccag
    15121 gtagctgccg ggcttgggcg aggtgtggaa gtagtcgtcg tggccgcagt ccagccgctg
    15181 gtcccccgtg cgctcgggac acaggacctg catcctgggg tagtgcgggg cgtccgagta
    15241 gcacatgatg tcccactcgt cgacgcagtg cgcggccttg ctggtgtgcg gggcgctgtt
    15301 gttgacggcg cccaggttgt ggcccagttc gtgggcgggg gtgctgccgc cccagcagcc
    15361 ggagtccgta cggccgtagg aggggccgaa gttgctgagg ttgtccgggc cggggcgctc
    15421 gtcaccgttg aaggtgccga tgccgcagta gacctgggcg tccgcgaaga tcatgtactt
    15481 gcggtcgcgg cggttgaatc ccttggcggc cagggcgttg ttcatcgccc cgaactcctg
    15541 cagggcgccc gcggagacct cgacgttcag gacggaggcg gtgcagtcgg cctcggtgac
    15601 gtagcggacg tgccgctcgc cgccggtctc cttggcactg gcgttgtaga tcacgtcggt
    15661 ctcggcggcc cactgcttga aggaggcggc gtactggccg aaccggtcgc gcccggacgc
    15721 gtggacgtac agaacctgga cgcggttgcc gctggaaccg tcgccctcac agacgacctt
    15781 ggagccggag ccggcctgcg ggttcgctgg cgcgccgggg cccggggccg cggcggccgc
    15841 ggccacgccg ccgcggcggg cgtcgatcac ggacggcgct ccgcccaggg cctccgaggc
    15901 cgagggggcc tggccgccgt caccggtcag ggaggaggga gcggccgtct tccccgccac
    15961 gggcggggtg tccttggtga tgtcgacgcc cttgggcggg gcgtcggggc cgtgggtgca
    16021 cagaccggcc cgcgagacgc tgtagacgcc gacgcagcgg tcgcccttgg gtgcgggctt
    16081 gaggccgtcg tagacgagac cgcgttgctt gtcggcccgg ggtgtggagg tcaggggggc
    16141 gggcggcttc ttgtgcaccg gctgcgcggc gggggcgctc gccgcctccg gctgcgggcc
    16201 cggggtggag gtggcggatc cggtgcccat gacgccgaag gcgattccgg cggccgcggc
    16261 ggctgcggcc gccgtgagta tcacgcggcg accggttctg ctgcggcggt gagtgtgctt
    16321 gcgtggcaaa ggagttccca tcggtggggg ggggttacgg gacggccggg cgtggcgcag
    16381 ggcccgcccg gcggaggggg gtggctcggg gcggcgctca gcgcgccgcg aagacctgca
    16441 tccagcgcgg gccgtcgtag gcgaaggaga cgccgacgcc cagctccgtg taggcgcagt
    16501 tgaggatggt ccggcggtgt cgggggtcgt ccatccacac ggacacgacc gcggaggcgc
    16561 tgctctgccc ggtggcggcg ttcaccccgt acgagctcca gtggtggccg ggcacggccg
    16621 cccggcgggc gaaggcggac cactggccgg cgggggtgcg cgacgcggtg tcgtcggtgt
    16681 ggcgctgagc gacggcgacg agctcggcgc tgaagcgcac gggcccgcat ccggccttgg
    16741 cgcgctcggt gttgacgatg cggacgacct cctgggcggg gcccgcgccc ggggcggccg
    16801 gcggtggcgt ccgccggggc gtggctccgg ccgggtcggg ggccgcgctc ggggcggccg
    16861 gcttctcggc ggcgggcccg gaggggctct tggccgcggc gggagtcgcg gcgggtgccg
    16921 gggccggcgg cgcggcgggg gcggaggcgc gcacgggagt acggccgtcg gtatcggagc
    16981 gggcgacggc cgtggcgtcg gtgcggtccg gcccggccgg cgtggggtcg ccggcggtga
    17041 ccgggacaac ctggaccggg ccgccgggtg cctgcggacg ggcgctctcg ggcgcggcgt
    17101 tgaagaggtg cgggccgccc agggtgccgc ccacgacgac gacggccacg acaccggcgg
    17161 cgacgacggc ccggcgcgcc aggcgcccga ggtcggcggg ggtgcccggc gccggctccc
    17221 cgggcggtgc ggagtccgcc gacggctccg gggccccggc ggaggcgctg ccgggagcgg
    17281 tggcggcgca ggccgccatg gggccgccgg ggggcgctgc ggtcacccgg gcgagcaggg
    17341 cggcgccgac ggggacgagc ccgaggccgg ccagcagccc ttccgcgggc acgagcgcgg
    17401 accagtgccc gccgcactcc gcgcagccgc gcgcgtgccg ggcgatgcgc ttgcgccaca
    17461 gggggctcgg cgcgccgtcc cagtcgccga gggcgcccgt gagctcgggg cagcgcgggt
    17521 ccgtggcgag cgcccggacg acgacgcggg cggtctccag ctgggccttg gtgcgctgga
    17581 cccggacggc ggtgtactgc ggcgagcggc ccagggccgc ggcgacctcg gcgcggctca
    17641 gctcgcccgc ggcctcctgc caccacaggg ccatgacgac ctggtcgtcg ccgtcgagcc
    17701 agcgcgtggc ctgtgcggcc tgtctgcgct gtccctgcag accgaggcgg atgatcgacc
    17761 actcgacgaa gtcgggctcg ggggcggcgg cttcgccgac ctcctgcagg ccgccggacg
    17821 gcgcgtcctt gcggtccttg agctccttgc gccagtggct gcgtatctgg ttcatggtga
    17881 tcgcgacgag ccacgagcgg aacccttcgg ggtcccgcag ggcgtgcagg ccgccgacca
    17941 tccggatcat ggtctcctgc acgacgtcgt cgacgtccgc gtgcccgttc agggcgcggc
    18001 cgacgatgtt gtagaccaac ggcaggcagg cggcgaccag ctggtcctgc gcggcgtcgt
    18061 ccccgccgcg cgccgcctcg accacaccgg ccgtgctgtc caagttcacg ttccgcccac
    18121 ctctttccgc tccaccgcat cggcggtctt acgcatggga gacctggggg cgtgcggcgg
    18181 ataacagaaa aatctgcggt tcggcggaat cttttttgcc gaggcgggta tgacgggtgc
    18241 tcacacccgg gcgagggccc tgtcagcagc cccgtccgca gtcccgttcc gcgccgtacg
    18301 gcgccccgta cggcgccggt aataggcgat ggtcacggcc gtcaggagcg gcggccaggc
    18361 cagcaggggg acgtagcaga cggcgaggag cgcgtcctgg gccgcggtgc cctgccagat
    18421 ggcctgctcc gggttcacgt agggggcgca gacgaaccag acggcgagtg cggccagtgc
    18481 cgtcgcgccc agcagcgccg ggaccaccgc cgcgagcggg cgcacccggc ggccgcccag
    18541 caaggggatc caccgcggca cgacttcgcc ccagggccgc acgagtccga gcgtgagcag
    18601 ggcgagggcc tcggagaccg cggtgagcga gaggacgtag agggctcccc agacggtcat
    18661 gtcgccgtcg ggcgcggcca ccgggagccc ggcgacgagt gcgatccgcc acagccccga
    18721 cggcagggtg accaggggca cggcgtgggc cgcgagcacg gcccatcggg gcacgtccgg
    18781 cagggcgttc atcttcagca tgggatccat gctggtggcg ggcccggcgc cccgcgtccg
    18841 cccgcggaac ggtcctcctc cgccgcgcgg cggaggacgg gctcacccgt cagggggcgt
    18901 cttcggccgc ggcggcgacg agttcggcct cgaagccgtc ctcgttctcc aggtacgcgg
    18961 cgtagtgggc gggcccgccg gcgaacgggt gctcgccggg gaacatcagc cgccagccgt
    19021 gttccggggc ctcctccacg agcgcgtcga cggcggcccg gctctccacg gggaaggcga
    19081 cgtggttcat gcccggcctg caccgctcgt gggtgccggc cgcgagcgcg ggcgactgct
    19141 cgacgacgag gtagaaggct ccgagccgcc agctgcggcc gtgctcccag cgctggtggg
    19201 gtgtgtagcc cagggcgccg agcagccagc cgaagctctt cgcggcgcgc tgcaggtcgg
    19261 gcacccacag ttcgagatga tgcagcacgc ccacgccccc ggcggtcagg tggtcggtcc
    19321 ggccggcccg gggctcaccg gatcggcacg tcggagatcg tacgggctat caccagccgc
    19381 tggatctcgc tcgtgccctc aaaaatggtg taaatagcgg catcgcggtg catccgctcc
    19441 accgggtact cgcgcgtgta gccgttcccg ccgaggatct gcatggcctg ggccgtgacg
    19501 gccttcgccg tctcgcccgc gaacagcttg gacatcgagc cctccgccgc ggtgaagggc
    19561 ttgcccgcgg tggccatcca ggacgcgcgc cacaccagca gccgggccgc gtcgatacgg
    19621 gtgcgcatgt cggcgagctg gaaggcgacg ccctggttgt cgatgacggg ccggccgaac
    19681 tggtggcgcg tctgggcgta gtcgagcgcc acctcgtacg cggcgcgggc gatgccgacg
    19741 gcctgggcgc cgaccgtggg gcgggaggcc tcgaaggtgg ccatggcggc gttgtgcgta
    19801 cgggcaccgc cggtgcgcac gcgctcgcgg gcgcgggcca ggcgctcgtc cagcttgtcc
    19861 ttgccgccga ggaggcagtg gccgggcagg cggacgccgt cgaggacgac ctcggcggtg
    19921 tgcgaggcgc ggatgccgtg cttcttgaac ttctgcccct gggagagccc cggggtgtcc
    19981 ggcgggacga tgaaggaggc gtggccgcgc gcgcccagct cggggtcgac gaccgcgacg
    20041 acgatgtgga cgttcgcgat gccgccgttc gtcgcccagg tcttcgtccc gttgaggacc
    20101 cattcgtcct tggcctcgtc gtagacggcg cgggtgcgca tggccgagac gtccgagccc
    20161 gcgtccggct cggaggagca gaaagcggcg atcttcacgt catgggcgtc gccgtacatc
    20221 tgcgggagcc aggtgccgat ctgctcctcg gtgccgttgg tgaggacgcc gatggcggcg
    20281 agtccggtcc cggtgatggc caagccgagg ccggcgtcgc cccagaagag ctcctccatg
    20341 gccatgggga tgccgaggcc ggtggggtcg aagaactgct gggcgtagaa gtcgagcgag
    20401 tacagcccaa tgcgggcggc ttcctggacg accggccacg ggaactcctc gcgctcgtcc
    20461 cactcggcgg cggccgggcg catcacttcg gccgcgaagc cgtggatcca gtcgcgcacc
    20521 ccccgctggt cctcgttgag ctccatcgtg aattcggcca tgcccgtctc ccacccctgc
    20581 cggcaaccct tactcgcggt aacatgagta tgttaccgac cggtagtagt gtcaaccgtc
    20641 ccgcctcccg gattcgctgg gtggagcggg tgttacgttg cgcaggcgtc aggaatcaca
    20701 ggggcgggga ggcaggtcat atggaaacca gtcagcggga ggaccagcag catgcggcgg
    20761 agcggcgccg caaggagctg ctcgaggcgg cggaccgggt ggtgctgcgg gaggggcccg
    20821 gtgcgtcgat gaacgccatc gcggccgagg cgggcatcac caagcccatc ctctaccggc
    20881 acttcggcga caagggcggg ctctaccgcg ccctggccgc ccggcac
//
