LOCUS       NZ_CP040752            22097 bp    DNA     linear   CON 05-MAY-2024
DEFINITION  Streptomyces rectiverticillatus strain B15-08 chromosome, complete
            genome.
ACCESSION   NZ_CP040752
VERSION     NZ_CP040752.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces rectiverticillatus
  ORGANISM  Streptomyces rectiverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7679243)
  AUTHORS   Park,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAY-2019) Laboratory of Bioorganic Chemistry, NIDDK,
            NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: DEC-2018
            Assembly Method                   :: HGAP v. Dec-2018
            Assembly Name                     :: DDK_LBC_B15-08
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013394065.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:49:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,642
            CDSs (total)                      :: 6,543
            Genes (coding)                    :: 6,394
            CDSs (with protein)               :: 6,394
            Genes (RNA)                       :: 99
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 149
            CDSs (without protein)            :: 149
            Pseudo Genes (ambiguous residues) :: 0 of 149
            Pseudo Genes (frameshifted)       :: 55 of 149
            Pseudo Genes (incomplete)         :: 125 of 149
            Pseudo Genes (internal stop)      :: 12 of 149
            Pseudo Genes (multiple problems)  :: 41 of 149
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:46:20
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 41671
            Orig. end                         :: 63768
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040752.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from LBC, NIDDK.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22097
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22097
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22097
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12097](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12097
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(133..1485)
                     /locus_tag="FGW37_RS00230"
                     /old_locus_tag="FGW37_00250"
     CDS             complement(133..1485)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013394.4"
                     /locus_tag="FGW37_RS00230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00250"
                     /product="7-dehydrocholesterol reductase"
                     /protein_id="WP_179079160.1"
                     /transl_table=11
                     /translation="MANRAPTSPASAAGTPGWTGSPRGRLARTVRRTVGPLTLLLITPP
                     IVLLLWALVVAFDGACRPLAEPARWPALVSALPYPSPWAALTITGFTVFEAALLRLLPG
                     PQWQGPVTPAGVRPAYRANGPAALAATHAAYLAASLGLGWFPPGVLYDRSGELLATACV
                     LAWALSAALYVKGLRRPSGPDHGTTGHVLLDVFRGTELHPSLGRIDLKQLFNCRVGMMS
                     WGLLLVSFAAAQHERFHGILSSMAVAAGLQLAYIVKFFHWETGYFATLDITHDRFGYYL
                     CWGVTVWLPGVYTLSTLYLVTHPRRLPLWETVLLLTTGLVALAVNYSADEQRQRVRRTG
                     GDTRIWGRPAKTLPARYVTSDGREHSTVLLCSGWWGLSRHFHYLPELVLAVCWVTPAGG
                     ARILPYFYPVYLAALLADRAGRDERRCLQKYGDAYRDYCRRVRWKVIPYLH"
     gene            complement(1511..2884)
                     /locus_tag="FGW37_RS00235"
                     /old_locus_tag="FGW37_00255"
     CDS             complement(1511..2884)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013739.4"
                     /locus_tag="FGW37_RS00235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00255"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_179079161.1"
                     /transl_table=11
                     /translation="MRERIAIVGAGAAGLGAAWALSRHPDRFDVEVYEAAPTLGGNART
                     EDFPQRDGGTVPADIAVTAFIPSVYHHYAELLRRLGIEAVTSRFSYAVHYGDDVYAHDL
                     DTPLRRRLAGDIAAFRRLLRTVGRFNTLSKRPSFTTAVFNPFNYVTMRRTLDLWGISQE
                     FRYKILKPLFVNFVLASGVFAMPASVFVRYMDFFDVEHSTPMVTWQGGTRAVYARLTEG
                     FTDRIRTGRPVTELFRRPDGVRVRDANGVTERFDQVILACNADHALAVLRPPGALERRV
                     LGAVRYESGPHRDAVVHTDASLLPDDELDVSATRSTFVRHYGDRPDNYEITYVMHNQQP
                     WGDGAASPRLVTYNARRQPDPDKVISRHRFQHVVHDVRHTVLLHALMPLLQGRRRTWYC
                     GAHTTFNSQEHAFVSGLAVARQLGADYPFPADTEAARWFDFYGRMCLGVRFRTVRRRT"
     gene            complement(2901..3812)
                     /locus_tag="FGW37_RS00240"
                     /old_locus_tag="FGW37_00260"
     CDS             complement(2901..3812)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (68-180). E-value: 2.4e-29. Score:
                     93.7. Matches aSDomain: nrpspksdomains_FGW37_RS00240_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="FGW37_RS00240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00260"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_179079162.1"
                     /transl_table=11
                     /translation="MTETTEAALERYRQLAAAGGAARTGHYRDLVTSYYDLVTDLYLEG
                     WGASHHFAPVKPGDSHADALAARQKFLAGRAGLHPGMKVLDVGSGVGGPALNIAGASGA
                     HVTGLDITPVRVEHARRRACDLGLQERTAFVEGDAMHMPFEDASFDVVYAVEAICHTAD
                     KDRSHAEIARVLKPGGLSIGYEWLAADGLSPAEVHHLIEPVCRYYALPHLATPGQLADQ
                     LRRAGLTDVVVGDAEATGDLASTWDYLDQLADLGEQLDDCPVRKFMIHGARALTRAARE
                     GAFLIDFWEARKPEAGPGTPAV"
     aSDomain        complement(3273..3608)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FGW37_RS00240_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.40E-29"
                     /label="FGW37_RS00240_oMT.1"
                     /locus_tag="FGW37_RS00240"
                     /protein_end="180"
                     /protein_start="68"
                     /score="93.7"
                     /tool="antismash"
                     /translation="QKFLAGRAGLHPGMKVLDVGSGVGGPALNIAGASGAHVTGLDITP
                     VRVEHARRRACDLGLQERTAFVEGDAMHMPFEDASFDVVYAVEAICHTADKDRSHAEIA
                     RVLKPGGL"
     gene            complement(3809..4318)
                     /locus_tag="FGW37_RS00245"
                     /old_locus_tag="FGW37_00265"
     CDS             complement(3809..4318)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017090.4"
                     /locus_tag="FGW37_RS00245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00265"
                     /product="emopamil-binding family protein"
                     /protein_id="WP_179079163.1"
                     /transl_table=11
                     /translation="MRRPAPRDRPVLGFLAFCLLVALSMELYFVLHFQDIDERHDLPAR
                     AFQIYGAGDRTYSGQGDTYLPFALETINVFLVQTLNCALAYAIVRPRAWRHPLQLAVGS
                     YLSGSVVIYFWHAHAAGYPDMPEHRFWNYFLFYAPNLPWLVGSLWMAVASFRTLVRSVK
                     EWETSR"
     gene            complement(4373..5908)
                     /locus_tag="FGW37_RS00250"
                     /old_locus_tag="FGW37_00270"
     CDS             complement(4373..5908)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013714.4"
                     /locus_tag="FGW37_RS00250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00270"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_179079164.1"
                     /transl_table=11
                     /translation="MSRTPVPRSARWLADHRWLYVVPVLLPLSKAYALAEALSARLRSR
                     RAGAVRRHRRRVALMQARVREHAAQGGEGRSGGGLMCTARPQWRSMSHSRNRFYKDGAF
                     LVPAQLDDILQVDAQRRTVTVGPAVTMGRLMAGLPDGWTLPVVPEMEDLTVGGLVMGYG
                     IETSSHRHGLFADNIESCEVLLAGGEVVVADRTRRADLFHALPWSRGTLGLLTSVQLRM
                     IPASPWVRLAYHRLGSAAALTDCLESYSSGPAPPDFVEGFRFSPTESVVVTGTLADRPR
                     GDGTVNRMGRWHKPWFHEHVRAQCRLRRNAEYVPLRDYYFRHSRSIYWAAEMLVPSGNH
                     PLFRYALGWLMPPKAAFLKRTETPGIRRLYLQNTVTQEALVPVRALPEAIEKCREAFHV
                     DRMWLCPVTLRRSEPEGLVSPGTADGLYVDIAVVFETPEPVRLGRRWDVRQATREFEAW
                     LLCNGGFQVPYVASHMTREEFWSMFAHRPYLAARKKYGAEGAFLDIYDKVSSN"
     gene            complement(5905..7089)
                     /locus_tag="FGW37_RS00255"
                     /old_locus_tag="FGW37_00275"
     CDS             complement(5905..7089)
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039236.3"
                     /locus_tag="FGW37_RS00255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00275"
                     /product="aromatic ring-hydroxylating dioxygenase subunit
                     alpha"
                     /protein_id="WP_218650556.1"
                     /transl_table=11
                     /translation="MSGATRRVRPAPAAPSGPPAFAEARSKRAKVRAAGMDPDYWYAVA
                     YESELPRGTTLATRFWGHPIVVYRGTEGSLHALEDRCAHRQLKLSAGEVNGCHLTCTYH
                     GWTYDGDGNVVHYAHDLFGRARPEVKVSGYPVTTRHGLVWIFPGDPALASVRTVPAIPE
                     LSGSRPWARLDASYTWQAHHSMIIDNVSDFSHSYLHRRYRPFWDAKLTHHELTGDRVEL
                     SYETCVGGGGLTSRFVDRRHVDTTSIDLAFDYPYQRSDTGGSIKHWCFVLPMDRRTSRV
                     FFVFYFDAVKVPGTRRALPRRLLPLFMCLAGALVVKPLLCEDGVAVESEQLGYEMHHAA
                     PIVELNPAVGLFQDLTIRKWQEFLDRDRARPRPSGIALADGRVVPGPRHRKGRP"
     gene            complement(7086..8537)
                     /locus_tag="FGW37_RS00260"
                     /old_locus_tag="FGW37_00280"
     CDS             complement(7086..8537)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="FGW37_RS00260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00280"
                     /product="cytochrome P450"
                     /protein_id="WP_179079165.1"
                     /sec_met_domain="p450 (E-value: 4.3e-56, bitscore: 189.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGTHEPGSRECAPAPRLPGRHLPWLGPLPAFHRDPVALLRAAR
                     ERVGNAFSFPLLGQDVVFVCGPEAHAEVFEADEAVLSPREAYRFMKPVFGPGIGYDAAT
                     PEEMDAQIAPIRPALGSRNLDAYARVMEAEARAQVACWPAAGEIDLLAELNRMSVAIAT
                     RCLIGEEFHRRMGPELPRLYHELESGVRLAGMLSPRLPIPAFRRRDRARAAIAEAIGEV
                     IAERRCRRPGDEPAGLPGSASAGLPGCVSGAVREQDMLAVLLAARTEDGRPLPDPVVTG
                     ILIGMIFAGQHTSAVLAAWTGVLLMRHPQYVPRLRAEQEEVWPPGSRLGTGALHRMELL
                     DSCVREAERLHPPLILLMRKALRDTAIRGHRVPAGSLVMISPAVAHRMPEVFRDPDRFD
                     PSRYGAGRCEHRRPYGLIGFGGGKHRCIGLAFAYLQVKAAWSVLLREVDLWPAESGYAP
                     DYSTFVPAPKAPCTVRYRKRSAEPS"
     gene            complement(8534..9595)
                     /locus_tag="FGW37_RS00265"
                     /old_locus_tag="FGW37_00285"
     CDS             complement(8534..9595)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (55-171). E-value:
                     1.5e-13. Score: 42.4. Matches aSDomain:
                     nrpspksdomains_FGW37_RS00265_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF027681.4"
                     /locus_tag="FGW37_RS00265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00285"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_179079166.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.2e-10,
                     bitscore: 38.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.9e-10, bitscore:
                     38.9, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.6e-11, bitscore:
                     42.4, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILVTGASGHLGANLVRRLLADGHEVRVLVRAPGTAAPALAGLPV
                     RRTVGDVRDPAAVEAAVEGCESVYHCAARVSTSARGSRDIHAVNVLGTRNVLDAARRHG
                     VRRVVVTGSFSATGSTPGRASTERDLHYPSGPHTPYTRSKVLVEHECCKAAAQGLDVVV
                     AVSTAIIGPHDYVPSRMGRVLLDFAHGRLFAYVPGGFEFVSVQDLVQGHLLAMERGLPG
                     HKYLLSTEFRTVDQMMDLYAQVTGRRKPRLRMPAPAMGVLARLAEGPRSVLTPHREARF
                     TPAAVRFLRSERRADCSLGREVLGYRPTDIATAVEQAYRCFANRGLVEPRGAARPARGP
                     AGRRGPVVGAGPR"
     aSDomain        complement(9083..9430)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FGW37_RS00265_NAD_binding_4.1"
                     /evalue="1.50E-13"
                     /label="FGW37_RS00265_NAD_binding_4.1"
                     /locus_tag="FGW37_RS00265"
                     /protein_end="171"
                     /protein_start="55"
                     /score="42.4"
                     /tool="antismash"
                     /translation="AAVEAAVEGCESVYHCAARVSTSARGSRDIHAVNVLGTRNVLDAA
                     RRHGVRRVVVTGSFSATGSTPGRASTERDLHYPSGPHTPYTRSKVLVEHECCKAAAQGL
                     DVVVAVSTAIIG"
     CDS_motif       complement(9533..9589)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_FGW37_RS00265_0001"
                     /evalue="1.40E-02"
                     /label="PKSI-KR_m1"
                     /locus_tag="FGW37_RS00265"
                     /protein_end="21"
                     /protein_start="2"
                     /score="8.2"
                     /tool="antismash"
                     /translation="LVTGASGHLGANLVRRLLA"
     misc_feature    complement(9765..9780)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.07"
                     /tool="antismash"
     gene            10001..12097
                     /locus_tag="FGW37_RS00270"
                     /old_locus_tag="FGW37_00290"
     CDS             10001..12097
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01787.1"
                     /locus_tag="FGW37_RS00270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00290"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_179079167.1"
                     /sec_met_domain="T2TS (E-value: 5.6e-91, bitscore: 304.3,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPDTATGGPEAFAPVPGAHRTYDAACGRLLGLQDERGAWEGEM
                     EWSTMILSQYVIVLHVLQRPPDERARKAILQGFRATRTAEGGWGMHPQGPPSPYATTLA
                     YVALRLLGTEPHEPLAAGARQWLHAQPGGCRSVPQWGLFWLALLGLVPYRQVAPVPPEA
                     MLLPAWAPLHPERLLGWTRMLYQGMAYLYGAKFRADPCPVVRDLRRELFAGQGAGARVP
                     PGRSTDVYVAGGPALRVLQGCLRGWERVHSRRLRRAALERCHRAVVEEQHASPHHGLSS
                     VNALVECLVLFARDRHHPLLDDAVARLHYWCWQDGKRGLRICGDRSVVWDTSFAVEALL
                     SGGAAGADHGPDRRLGSAIDRAHAFLRKAQITTYSGRVPPLRTVRHGWAFSDGDSRWPV
                     SDCTAEAVGALLQAQEVTGPGGHRVPVSARLGRPALHGALNVVLDRQNPDGGFGTLDRR
                     RAGTWLEALNPTEMFAGCMTDTSSVECTGSVLTALSRMRPLLEPVARRRAGQAMARGID
                     YIRACQHPDGSFSGTWGINYTYAAFHAARGLRAAGVPADDPAPVALARWLEGSQLKDGS
                     WGEDWRSCLERRYLALDTGLPEMTAWAVLAGLDTLGPRHPVVENGIRWLCAHQQADGSW
                     TGGHVNGVFFGTMMLVYHLYPVYFPALAVGRYLRAVALSAPSTTAEPVASEGPAGPDGP
                     AGAP"
     gene            12094..13476
                     /locus_tag="FGW37_RS00275"
                     /old_locus_tag="FGW37_00295"
     CDS             12094..13476
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="FGW37_RS00275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00295"
                     /product="cytochrome P450"
                     /protein_id="WP_179079168.1"
                     /sec_met_domain="p450 (E-value: 1.4e-40, bitscore: 138.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDAQAAAQPGGRNLPKADGGLPVIGHAIPFFQDPVGFLLRAHG
                     RQGEAVTFSLPGRRVASFCGPQANAVVLSLDDTEADRRPVYEPLLAPLLGRGVGFNAPA
                     DVMTWHHSLLLPHLRRDALTRHAAIMFDQMERYVAPWNGDGTFDLMAVMRDITARISAH
                     CLIGPRFGRTLAPVLPALLSRLEASFFMSFAIGPRPFLPHHRRADRARETLTRAIKEIA
                     PRDRPEGKKRSHFEELMRAEGPDGRSLDEETAAALMLSWLFAAVPITIHAAWTGVLLLQ
                     HPQWLPVLRAEQESAFTDYPPTTLSPLHKLERLGHCLLEAERLHPAIWLLPRLAVRDLC
                     IRGYRVPRGYLVCASPGASHRLPDVFRDPGAFDPDRYLPDQYLPDRTEHGTAHHALIGF
                     GGGRHPCLGPAFAQQAIKVIWSVLLRAFDLELAGPDVREVRASVFHPPRQPCTVRYRRR
                     KR"
     gene            13483..14775
                     /locus_tag="FGW37_RS00280"
                     /old_locus_tag="FGW37_00300"
     CDS             13483..14775
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1161: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="FGW37_RS00280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00300"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_179079169.1"
                     /sec_met_domain="DAO (E-value: 2.3e-08, bitscore: 32.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPPCDVAVIGAGPVGCAAALAHARAGHRVLLLEASRRPPTRLAG
                     EWIHPGGVAVLRRLGVGTPAPSFLPALGFILHPEDSSPPITLPCPRGDRAATARHCELV
                     ATLRAVAADDPAITLALGTRITSIRRTTVTYTREGGPERHARVWRVVGADGQSSVVRRT
                     IHCAAPATTVSRTAGVLLRGLALPAEGYGHVFAGGPGPVLAYRLDDDTVRVTVDVPLSR
                     RRAAELPSYVRRVYSPFLPADLAGLLCTALERKEAVQWAANRVRLRTFHGREPHVLVGD
                     AVGTCHPLTASGLTIGLRDAECLAGTEDVTAHGRRRRAAVRPHEHLAAALHRIFCDPGR
                     TTRDLRRSMYAVLRASGTERERMMRLLCAEELGPLPLTGAVLHVAGHALHEQLVTGRCR
                     TNPWRTSVQACGDYLGWLRWMSRPPGHGWGK"
     gene            complement(14852..15964)
                     /locus_tag="FGW37_RS00285"
                     /old_locus_tag="FGW37_00305"
     CDS             complement(14852..15964)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013394.4"
                     /locus_tag="FGW37_RS00285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00305"
                     /product="hypothetical protein"
                     /protein_id="WP_179079170.1"
                     /transl_table=11
                     /translation="MAALALMDFVLVAFVLVLFAGSRWIPGRSVPAAATEDLAAAGDTD
                     TETEPPRAYRLNGAWLFALTAGAAAGFWIWSPRVLVWPDRHWGELLLVANAFAFALAWL
                     LFRTGRRRTPAASGPSGRRRGLSDYFYGVERNPVWAGVDLKFFSYRPSLIGLFVFNVSA
                     AAVQYTGQGSLSGRMLLYQIFFFVYLANYFQFEGGMVHTWDLIAERFGWMLVWGDYVLV
                     PFFYGISGRTLIHVREPLPLWLGAVCCALFVFGFWLFRGANDQKHRFKTGGAVTIWGRP
                     AETLGGRLLVSGFWGIGRKLNYTGELLVYLSWTLLCGTGSVVPYLLPAFLLLMFVHRAH
                     RDDRRCRVKYGRLWEEYCRRARFRMFPFVY"
     misc_feature    15966..15981
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.58"
                     /tool="antismash"
     gene            16304..18424
                     /locus_tag="FGW37_RS00290"
                     /old_locus_tag="FGW37_00310"
     CDS             16304..18424
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015155.4"
                     /locus_tag="FGW37_RS00290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00310"
                     /product="MMPL family transporter"
                     /protein_id="WP_179079171.1"
                     /transl_table=11
                     /translation="MGLFGAGGLDRLSNTWPVPIGSRAARDSAALGERYGFSGPDLVLL
                     LSTTSDVRSPEVAAAGRAVEEEVRRSPGVGAVSSYWSANDPALISRDARSALVSADLTG
                     EEALRAGAARRLVAALGEHRGPLTITPTGAAWTLEEILEDNRADLLRAELISAPACALI
                     LLFVFRSLVAALLPVVSALIATAGTLAFLRLLTSFTEVSVYASNIATALGLGLAVDYGI
                     LVVSRFREESTAGVSLREAVERSVRTAGRAVVVSAGIVLACVSSLLVFPFVFLRSAAWA
                     AVAVVVFSAAASVIVVPALLALLGRNTDRFDLFARLRRRNSRGPEGSPGWRRATLAVTR
                     RPVVAALAAACALTAMSLPAWHVSLGPSGVDDLPHRSRARTAAVIIRQDFASAPERELI
                     VGLPKGTPREEVEGRARTVSALPQTAFVRTFTGRYRGGTKVEAPGPWDTRQDAPAGPVM
                     VVASRFPPGTERSAVLVRQLRTLPAHGHVLVAGRAAEAVDSLSAVRRALPWCCGVVAAA
                     TFVLMALFTRSLLVPFKAVVVAAMSLGATLGCLVYVFQDGHLRSVVGDFHAPGYLSDTT
                     TVFLLATAYALAVDYEVFIVARIREEFLASGDNTAAVVAGMQRTGRLVTAASLVFAAAM
                     AGPATSGVTSLKLTGTGLALAVVVDAVVVRGALVPGLMTLAGRANWWLPRGWRRRSRRT
                     AGRANGSDMRKP"
     misc_feature    18592..18608
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.29"
                     /tool="antismash"
     gene            18724..19611
                     /locus_tag="FGW37_RS00295"
                     /old_locus_tag="FGW37_00315"
     CDS             18724..19611
                     /NRPS_PKS="Domain: Abhydrolase_1 (60-170). E-value:
                     1.2e-14. Score: 46.5. Matches aSDomain:
                     nrpspksdomains_FGW37_RS00295_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018556052.1"
                     /locus_tag="FGW37_RS00295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00315"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_246430180.1"
                     /sec_met_domain="PF00561 (E-value: 1.9e-11, bitscore: 42.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.8e-07, bitscore:
                     30.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGFRNVSRLVCSVLSAVALTIAVGSTASAASAASTTDRPSAVSS
                     GWNDYDCKPSAAHPRPVVLVHGTLGNSVDNWLVMAPYLVKRGYCVFSLDYGKLPGVPVF
                     YGLGPIAKSAEELSVFVDKVRAATGVDKVDMVGHSQGGMMPRYYINFLGGADKVNHLIG
                     LAPSSHGTTMMGLTKLMDAVPGARKALGGMAPGLTDQALGSDFLKRLNASPDTMPGVEY
                     SVIATKYDQVVTPHGTNFLSGPNVRNIMLQDLCALDLSEHISIGSIDRIVVHKVANLLD
                     PANAEPTTCASVVS"
     misc_feature    18766..18768
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        18904..19233
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FGW37_RS00295_Abhydrolase_1.1"
                     /evalue="1.20E-14"
                     /label="FGW37_RS00295_Abhydrolase_1.1"
                     /locus_tag="FGW37_RS00295"
                     /protein_end="170"
                     /protein_start="60"
                     /score="46.5"
                     /tool="antismash"
                     /translation="PVVLVHGTLGNSVDNWLVMAPYLVKRGYCVFSLDYGKLPGVPVFY
                     GLGPIAKSAEELSVFVDKVRAATGVDKVDMVGHSQGGMMPRYYINFLGGADKVNHLIGL
                     APSSHG"
     gene            20061..20840
                     /locus_tag="FGW37_RS00300"
                     /old_locus_tag="FGW37_00320"
     CDS             20061..20840
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173248.1"
                     /locus_tag="FGW37_RS00300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00320"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_179079173.1"
                     /transl_table=11
                     /translation="MDQDERLLHASSFGAVAVAYAEHRPDYAQAAVRWALEPVPGPRVL
                     DLGAGTGKLTTTLVALGAEVIAVEPDPDMLTELRRSLPAVRALPGRAEAIPLPDASVDA
                     VLAGNAMHWFDMAVAGPEIARVLAPGGVLVGLWNLMDDQVEWVARLARVSGNAAIGPRD
                     TPAGWRAATADMHLPKTVAAARFGSPEQTEFPHGQPRTADSLVATIATRAGVLVMPGQE
                     QEATLGRIRAFLASEPEAARGEFTLPMLTGVLRIRRL"
     gene            complement(20997..21353)
                     /locus_tag="FGW37_RS00305"
                     /old_locus_tag="FGW37_00325"
     CDS             complement(20997..21353)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644969.1"
                     /locus_tag="FGW37_RS00305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FGW37_00325"
                     /product="DUF805 domain-containing protein"
                     /protein_id="WP_179084414.1"
                     /transl_table=11
                     /translation="MHWYVDVLKKYATFSGRASRPEFWMFTLISLVVSIVLAVIDVLLG
                     TGIIIETVYDVAVLLPSLAVSVRRLHDTDRSGWWLLIGLIPIVGLIVLIVFWAAAAKPQ
                     ENAYGTNPQKVPAR"
     misc_feature    21322..21331
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     misc_feature    complement(21494..21507)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.47"
                     /tool="antismash"
     misc_feature    21641..21654
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.54"
                     /tool="antismash"
     misc_feature    21828..21846
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     misc_feature    complement(21964..21978)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 cgactatccg cgcaaatccg gacacatatc cagactgcac ctgaaccgcc ctggacgcat
       61 ccgggacacc gcccgcggct actcctcagt ctctccgccc gacccgctct acgcggccgg
      121 cgagtgcgcc cctcagtgga ggtacgggat caccttccag cgcacccgac ggcagtagtc
      181 gcggtaggcg tcgccgtact tctgcaggca gcgtcgctcg tcgcggccgg cgcggtcggc
      241 cagcagggcg gccaggtaca ccgggtagaa gtagggcagg atccgggcgc cgccggccgg
      301 agtcacccag cacacggcca gcaccagctc cggcaggtag tggaagtgcc gggacagacc
      361 ccaccaaccc gagcagagca gcaccgtcga gtgctccctc ccgtcgctcg tcacgtagcg
      421 tgcgggcagc gtcttcgccg ggcgccccca gatccgggtg tcgccgccgg tgcgccgtac
      481 gcgctggcgc tgttcgtcgg ccgagtagtt gacggcgagc gcgacgagtc cggtggtcag
      541 cagcagcacg gtctcccaca gcggcaggcg gcgcggatgg gtgacgaggt agagggtgct
      601 gagggtgtat acgccgggca gccataccgt cacgccccag cacaggtagt acccgaagcg
      661 gtcgtgcgtg atgtcgaggg tcgcgaagta gccggtctcc cagtggaaga atttcacgat
      721 gtaggcgagc tgcagcccgg ccgccaccgc catcgacgac aagatgccgt ggaaccgttc
      781 gtgctgtgcg gcggcgaacg acaccagcag cagcccccac gacatcatcc cgacccggca
      841 gttgaagagc tgcttcagat cgatgcggcc gagggacgga tgcagctccg tgccccggaa
      901 gacgtcgagg agcacgtgac ccgtcgtccc gtgatcgggc ccggagggcc gtcgcaggcc
      961 cttgacgtac agggcggccg acagcgccca ggccaggacg catgccgtgg ccagcagctc
     1021 gccggagcgg tcgtagagca cgccgggcgg gaaccagccg agccccaggg acgcggcgag
     1081 atacgcggcg tgggtcgcgg ccagcgcggc cgggccgttg gcacggtagg cgggacggac
     1141 gccggccggt gtgaccggcc cctgccactg agggcccggc agcagacgca gcagcgccgc
     1201 ttcgaacacg gtgaagcccg tgatggtgag ggccgcccac gggctcgggt acgggagcgc
     1261 ggacaccagg gcgggccatc gcgccggctc ggcgagcggc cggcaggcgc cgtcgaacgc
     1321 gacgacgagc gcccacagga gcagcacgat cggcggtgtg atcagcagca gggtcagcgg
     1381 gcccaccgtg cggcgcacgg tccgggccag gcgaccccgc gggctaccgg tccagccggg
     1441 cgttccggcg gcggacgccg ggctcgtcgg tgcacggttc gccatggggc ctcttctgat
     1501 gcggggccgg tcacgtccgc cggcggacgg tgcggaagcg cacgcccaga cacatgcggc
     1561 cgtagaagtc gaaccaccgg gcggcctcgg tgtccgccgg gaacgggtag tccgcgccca
     1621 gctggcgggc cacggccaga cccgatacga aggcgtgctc ctggctgttg aaggtggtgt
     1681 gggccccgca gtaccaggtc ctgcggcgac cctgcagcag gggcatcagc gcgtgcagca
     1741 ggacggtgtg ccgcacgtcg tggacgacgt gctggaaccg gtggcggctg atgaccttgt
     1801 ccgggtccgg ttgccgtcgg gcgttgtagg tcaccaggcg gggcgacgcg gcgccgtcgc
     1861 cccagggctg ctggttgtgc atgacatacg tgatctcgta gttgtcgggc cggtcaccgt
     1921 agtgccgcac gaacgtgctg cgggtggcgg agacgtccag ctcgtcgtcc ggcaggagtg
     1981 aggcgtcggt gtgcacgacc gcgtcccggt gcggcccgga ctcgtagcgc acggccccga
     2041 gcacgcggcg ctccagggcg ccgggcggcc ggagcacggc cagggcgtgg tcggcgttgc
     2101 aggccaggat cacctggtcg aatcgttcgg tcactccgtt cgcgtcgcgt acccgcaccc
     2161 cgtccggtcg gcggaacagt tccgtcacgg ggcgcccggt acggatgcga tcggtgaacc
     2221 cttcggtgag gcgggcgtag acggcgcggg tgccgccctg ccaggtgacc atcggcgtgc
     2281 tgtgctcgac gtcgaagaag tccatgtacc ggacgaacac ggaagccggc atggcgaaga
     2341 cgcccgaggc gaggacgaag ttcacgaaca gcggcttgag gatcttgtag cggaactcct
     2401 gcgagatgcc ccacaggtcg agggtccggc gcatggtgac gtagttgaac gggttgaaca
     2461 ccgccgtggt gaacgacggc cgcttgctga gggtgttgaa ccttccgacg gtgcgcagca
     2521 ggcgccggaa ggcggcgatg tcgccggcca gtctccgccg caacggtgtg tcgaggtcgt
     2581 gggcgtagac gtcgtcgccg tagtgcacgg cgtagctgaa gcggctggtg acggcttcga
     2641 tgccgagccg gcgcagcagt tcggcgtagt ggtggtagac ggaggggatg aaggcggtga
     2701 cggcgatgtc cgcgggtacg gtaccgccgt cccgctgcgg gaagtcctcg gtccgggcgt
     2761 tgccgccgag cgtgggggcg gcctcgtaca cctcgacgtc gaagcggtcg gggtggcggc
     2821 tgagcgccca cgcggccccc agaccggccg caccggcccc cacgatcgcg atccgttccc
     2881 gcactgcgca cccccttgcc tcacacggcg ggcgttcccg gcccggcctc cggcttgcgc
     2941 gcctcccaga agtcgatgag gaaggcgcct tcccgtgccg cccgcgtcag ggcgcgggcg
     3001 ccgtggatca tgaacttcct gacggggcag tcgtcgagct gctcgccgag atcggccagc
     3061 tggtccaggt agtcccaggt ggaggcgagg tctcctgtcg cttcggcgtc gcccacgacg
     3121 acgtcggtga ggcctgcgcg ccgcagctgg tcggcgagtt gtccgggcgt ggcgaggtgc
     3181 ggcagggcgt agtagcggca gacgggctcg atgaggtggt ggacttctgc gggggacagt
     3241 ccgtcggcgg ccagccactc gtatccgatc gagagtccgc cgggcttgag gacccgggcg
     3301 atctcggcgt ggctgcggtc cttgtcggcc gtgtggcaga tggcctcgac ggcgtagacg
     3361 acgtcgaacg aggcgtcctc gaagggcatg tgcatggcgt cgccctcgac gaacgccgtc
     3421 cgctcctgca gtccgaggtc gcacgcccgc cggcgggcgt gctcgacccg caccggggtg
     3481 atgtccaggc cggtcacgtg ggcgccggag gcgccggcga tgttgagcgc cgggccgccc
     3541 accccgctgc ccacgtcgag gaccttcata ccggggtgca ggcccgcacg gccggcgagg
     3601 aacttctggc gcgcggccag cgcgtcggcg tgggagtcgc cgggcttcac gggggcgaag
     3661 tggtgggagg ccccccagcc ctccaggtac aggtccgtga ccaggtcgta gtaggacgtc
     3721 acaaggtcgc ggtagtggcc ggtgcgggcg gcgccgcccg cggcggccag ttgccggtag
     3781 cgctcgagcg ccgcctcggt ggtttcggtc atcgggaggt ctcccattcc ttcacggacc
     3841 ggacgagggt ccgaaacgag gcgacggcca tccagaggct gcccacgagc caggggaggt
     3901 tcggggcgta gaagaggaag tagttccaga accggtgctc cggcatgtcg gggtatcccg
     3961 cggcgtgggc gtgccagaag tagatgacga ccgagccgga gagataggag ccgacggcga
     4021 gctggagggg gtggcgccag gcacgcgggc gcacgatggc gtaggccagt gcgcagttga
     4081 gtgtctggac gaggaatacg ttgatggtct ccagggcgaa ggggagatag gtgtcgccct
     4141 gcccggagta cgtccggtcc cccgctccgt agatctggaa tgcgcgcgcc ggcaggtcgt
     4201 gccgttcgtc gatgtcctgg aagtggagga cgaagtacag ctccatggac agcgccacga
     4261 ggaggcagaa ggcgaggaag cccagcaccg gacggtcgcg cggggccgga cgtcgcaccg
     4321 gcgggggcgc cggatgcggg gatagtggca cggtcgtcgc cctcctgagg ggtcagttgg
     4381 agctcacctt gtcgtagatg tcgaggaagg cgccctccgc tccgtacttc ttgcgcgcgg
     4441 cgaggtaggg ccggtgggcg aacatggacc agaactcctc gcgcgtcatg tgcgaggcca
     4501 cgtaggggac ctggaacccg ccgttgcaca gcagccatgc ctcgaattcc ctggtggctt
     4561 gccggacgtc ccagcggcgc ccgagccgga ccggttccgg cgtctcgaag acgacggcga
     4621 tgtcgacgta gaggccgtcc gcggtgccgg ggctcaccag gccctccggc tcggagcggc
     4681 gcagcgtcac cgggcacagc cacatgcggt ccacgtggaa cgcctcgcgg cacttctcga
     4741 tcgcctccgg cagcgcgcgc acgggcacga gggcctcttg tgtcaccgtg ttctgcaggt
     4801 acaaccggcg gatgcccggc gtctcggtgc gcttgaggaa cgcggccttg ggcggcatga
     4861 gccagcccag ggcgtaccgg aacagcgggt ggttgccgct cgggacgagc atctcggccg
     4921 cccagtagat gctgcggctg tgccggaagt agtagtcccg cagcggcacg tactcggcgt
     4981 tgcgccgcag ccggcactgc gcccggacgt gctcgtggaa ccagggtttg tgccaccgcc
     5041 ccatccggtt gaccgtgccg tctccgcgcg ggcggtcggc gagcgtcccg gtgaccacga
     5101 cgctctccgt cggcgagaag cggaagccct ccacgaagtc gggcggggcc gggccggagg
     5161 agtacgactc gaggcagtcg gtgagcgcgg ccgcgctgcc gagccggtgg taggcgaggc
     5221 ggacccacgg ggaggccggg atcatccgca gctggaccga ggtcagcagt cccagcgtgc
     5281 cgcggctcca cggcagggcg tggaagaggt ccgcgcggcg ggtgcggtcc gccactacga
     5341 cctcaccgcc ggccaggagg acttcgcagg attcgatgtt gtccgcgaac aggccgtggc
     5401 ggtgggagga cgtctcgatg ccgtagccca tgacgaggcc gccgacggtg aggtcttcca
     5461 tctccggcac gaccggcagg gtccagccgt ccggcagccc ggccatcagg cgtcccatgg
     5521 tgacggcggg accgaccgtc acggtcctgc gctgcgcatc cacctgaagg atgtcgtcca
     5581 gctgtgccgg gaccaggaac gccccgtcct tgtagaacct gttgcgggaa tgcgacatcg
     5641 accgccactg cgggcgggcc gtgcacatca gccctccccc gctccggcct tccccgccct
     5701 gcgctgcgtg ctcgcgcacg cgggcctgca tgagggccac ccggcgccgg tggcgccgca
     5761 cggcgcccgc acggcggctg cgcagccggg cggacagcgc ctcggccagt gcgtacgcct
     5821 tggacagcgg cagcaggacc gggacgacgt acagccagcg gtggtcggcc agccaccggg
     5881 cggaacgggg tacgggcgtc cggctcatgg gcgtcctttc ctgtggcggg ggccggggac
     5941 gacgcgcccg tcggcgaggg cgatgcccga cgggcggggg cgggcccggt cgcggtcgag
     6001 gaactcctgc cacttgcgga tggtgaggtc ctggaagagg cccaccgcgg ggttgagctc
     6061 gacgatcggg gcggcgtggt gcatctcgta gccgagctgc tccgactcga cggccacgcc
     6121 gtcctcgcac agcagcggct tgacgacgag cgcgccggcc aggcacatga acagcggcag
     6181 cagccggcgg ggcagcgccc gccgggtgcc ggggaccttc accgcgtcga agtagaagac
     6241 gaagaacacc cggctggtgc gccggtccat cggcagcacg aagcaccagt gcttgatcga
     6301 ccctcctgtg tcggagcgct ggtaggggta gtcgaaggcg aggtcgatgg aggtggtgtc
     6361 cacatggcgc cggtccacga agcgggaggt gaggcccccg ccgcccacgc aggtctcgta
     6421 cgacagctcc acccggtccc cggtcagctc gtggtgcgtg agcttggcgt cccagaaagg
     6481 gcggtagcgg cggtgcagat agctgtggga gaagtcgctg acgttgtcga tgatcattga
     6541 gtggtgggcc tgccaggtgt acgaggcgtc cagccgggcc cacggcctgc tccccgacag
     6601 ctcggggatg gccgggacgg tccgcacgga ggccagggcg gggtcaccgg ggaagatcca
     6661 gaccaggccg tgccgggtgg tcaccggata gccgctcacc ttgacctcgg gccgggcgcg
     6721 gccgaacagg tcgtgggcgt agtgcacgac gttgccgtcg ccgtcatagg tccagccgtg
     6781 gtacgtgcag gtcaggtggc agccgttgac ctcgcctgcg gaaagtttca gctgcctgtg
     6841 cgcgcagcgg tcctccaggg cgtgcagact gccctccgta ccgcggtaga ccacgatcgg
     6901 atggccccag aagcgggtgg ccagggtcgt gccgcggggc agttcgctct cgtacgcgac
     6961 ggcgtaccag tagtcggggt ccatgccggc tgctcgcacc ttggcgcgct tgctccgggc
     7021 ctcggcgaac gccggcggtc cggagggggc cgcgggcgcc gggcggacgc gccgggtggc
     7081 gccgctcacg acggctccgc ggaacgcttg cggtaccgga cggtgcaggg ggccttcggg
     7141 gcggggacga aggtcgagta gtcgggcgcg tagccggatt cggcgggcca caggtccacc
     7201 tcgcgcagca ggacgctcca cgccgccttg acctggaggt aggcgaaggc gagcccgatg
     7261 cagcggtgct tgcccccgcc gaagccgatg aggccgtagg ggcggcggtg ctcgcagcgc
     7321 ccggccccgt agcgggaggg gtcgaagcgg tcggggtccc ggaacacctc gggcatgcgg
     7381 tgcgccaccg cgggcgagat catgaccagc gacccggccg gcacgcggtg gccgcggatc
     7441 gcggtgtcgc gcagcgcctt gcgcatcagc aggatcagcg gcgggtgcag ccgctcggcc
     7501 tcgcggacac agctgtcgag gagttccatg cggtgcaggg caccggtgcc gagccggctg
     7561 ccgggcggcc acacttcctc ctgctcggcg cgcagccgcg ggacgtactg cgggtggcgc
     7621 atgagcagca cgccggtcca tgcggcgagc accgcgctcg tgtgctggcc cgcgaagatc
     7681 attccgatga ggatgccggt gacgacggga tcgggcaggg gccggccgtc ctcggtgcgg
     7741 gccgcgagca gcacggcgag catgtcctgt tcgcggacgg ctccggaaac gcagccgggg
     7801 aggccggcgg aagcggagcc gggaaggccg gcgggctcgt ccccgggacg cctgcagcgg
     7861 cgctctgcga tgacctcgcc gatggcctcg gcgatggccg cgcgggcccg gtcgcggcgc
     7921 cggaaggcgg gaatcggcag tctcgggctg agcatgcccg cgagccggac gccgctttcc
     7981 agctcgtggt agagacgggg cagctccggg cccatgcggc ggtggaactc ctccccgatg
     8041 agacagcgcg tggcgatggc cacgctcatc cggttcagct cggcgagcag gtcgatctcg
     8101 cccgccgccg gccagcacgc cacctgggcc cgcgcctccg cctccatgac gcgggcgtac
     8161 gcgtcgaggt tccgggagcc gagtgcgggc cggatggggg cgatttgcgc gtccatctcc
     8221 tccggggtgg cggcgtcgta tccgatcccg ggcccgaaga ccggcttcat gaaacggtac
     8281 gcctcgcgcg ggctgaggac cgcctcgtcc gcttcgaaca cctcggcatg cgcctcgggt
     8341 ccgcagacga agacgacgtc ctggcccagc aaggggaagg agaatgcgtt gccgacccgt
     8401 tcccgcgcgg cgcgcagcag ggcgaccggg tcgcggtgga acgccgggag cgggcccagc
     8461 cacggcaggt gacggcccgg caggcgaggt gcgggagcgc actcccggct gcccggctcg
     8521 tgggttccgg ccgtcatcgc ggccccgccc ccacgacggg cccgcgccgc ccggcggggc
     8581 cgcgcgcggg cctcgccgcc ccgcgcggtt ccaccagtcc gcggttcgcg aagcagcggt
     8641 aggcctgctc gacggcggtg gcgatgtccg tgggacggta gcccaggacc tcccggccga
     8701 gggagcagtc cgcccgccgc tcggagcgca ggaagcgcac ggcggcgggg gtgaagcgcg
     8761 cctcgcggtg cggtgtcagc accgaccgcg gtccctcggc gagccgggcc agcaccccca
     8821 tggccggtgc gggcatccgc aggcgcggct tgcggcgtcc ggtgacctgc gcgtaaaggt
     8881 ccatcatctg gtcgaccgtg cggaactcgg tggacagcag gtacttgtgt cccggcaggc
     8941 cgcgttccat ggccagcaga tggccctgca cgaggtcctg gacggagacg aactcgaagc
     9001 caccggggac gtaggcgaac agccttccgt gggcgaagtc cagcagcacg cgccccatcc
     9061 gggacgggac gtagtcgtgc gggccgatga tcgccgtcga tacggcgacc accacgtcga
     9121 gcccctgggc cgcggccttg cagcactcgt gctccaccag caccttgctg cgcgtgtacg
     9181 gggtgtgggg cccggacgga tagtgcagat cgcgctccgt gctcgcccgg cccggggtcg
     9241 agcccgtggc gctgaacgac ccggtcacca cgacgcggcg cacgccgtgc cgccgcgccg
     9301 catccagcac gttgcgcgtg cccagcacat tgaccgcgtg gatgtcacga ctccctcgcg
     9361 ccgaggtcga gacgcgcgcg gcgcagtggt acacgctctc gcagccttcg acggcggcct
     9421 cgaccgccgc ggggtcgcgc acgtcgccga ccgtccggcg gacggggagt ccggccaggg
     9481 ccggggcggc cgttccgggg gcccggacga gtacccggac ttcatgaccg tcggcgagca
     9541 gacgccgcac aaggttcgca ccgaggtggc cgcttgcgcc tgtcacaagg atcacggatc
     9601 tccccctcca ccgctttcgg gagccacacc tccgtctaaa ggattccact cggcggcaga
     9661 acgcccggca ctgcttcggc gcatcccgca gtggtcctgc gaatcctgtg ggtaatgcac
     9721 gggaaggctt cccggcccct cgggtgaaaa tcccgcaccc ggggtcgcac gggaactcga
     9781 aggcggcgcg cggattcagc cgcgctcctc tcccgaccgc ctcacggacg agcatcacag
     9841 gagctccgta ccatgacgca gccaatcata aggccatcag atttccatgt tatagggagt
     9901 ttcttttctc ctccctcggc ggcttatcga tcagaagcgg aaggcagatt ctccatagtc
     9961 gctcgcgtac cccggcagat ccgaaagagg atgacggcac atggcgatgc ccgataccgc
    10021 caccggcggc cccgaggcct tcgcgcccgt gcccggcgcg caccgcacgt acgacgccgc
    10081 ctgcgggcgc ctgctcggcc tccaggacga aaggggtgcg tgggagggcg agatggagtg
    10141 gagcaccatg atcctctccc agtacgtcat cgtcctgcac gtcctgcaac gccctccgga
    10201 cgagcgggca cggaaggcga tcctccaggg cttccgggcg acccgtacgg ctgagggagg
    10261 ctggggcatg cacccgcagg gcccgccgtc gccgtacgcc acgacgctgg cctacgtggc
    10321 cctgcgcctg ctcggcacag aaccccatga accactcgcc gccggtgccc ggcagtggct
    10381 ccacgctcag ccgggcggct gccgctccgt tccgcaatgg gggctcttct ggctcgcctt
    10441 gctgggcctg gtgccctacc gtcaggtggc gccggttccc cctgaggcga tgcttctgcc
    10501 cgcgtgggcg cccttgcacc ccgaacggct cctgggctgg acccggatgc tctaccaagg
    10561 catggcctac ctgtacggcg cgaagttccg cgcggacccg tgtcccgtcg tccgcgacct
    10621 ccgccgcgag ctgttcgccg gccagggcgc aggagcccgt gtgccacccg gccgaagcac
    10681 cgacgtgtac gttgccggag gccccgcact gcgcgtgctg caggggtgcc tgcgcgggtg
    10741 ggagcgggtg cacagccgcc gcctgcgccg cgctgccctg gagcgctgtc accgcgcggt
    10801 cgtcgaggag cagcacgcct caccgcacca cggcttgtct tcggtgaacg ccttggtgga
    10861 gtgcctggtg ctgttcgccc gcgaccggca ccaccccttg ctggacgacg ccgtcgcccg
    10921 cctgcactac tggtgttggc aggacggcaa gcgcggcctg cgcatctgcg gggaccggtc
    10981 cgtggtgtgg gacacctcct tcgccgtgga agcgctcctg tcgggaggcg ctgcaggggc
    11041 ggaccacgga ccggaccgcc ggctgggctc cgcgatcgac cgagcacacg ctttcctgcg
    11101 caaggcgcag atcaccacct acagcggacg tgtgccgccc ttgcgcaccg tccgccacgg
    11161 ctgggcgttc tccgacggcg acagccgctg gcccgtcagc gactgcacgg ccgaagccgt
    11221 gggcgccctg ttgcaggcac aggaggtgac gggccccggc ggccaccggg ttccggtttc
    11281 ggcccgcctc ggccgaccgg ccctgcacgg cgcgttgaac gtcgtgctgg accggcagaa
    11341 ccccgacggc gggttcggca ccctcgaccg ccggcgtgcc ggcacctggc tggaggccct
    11401 caacccgacg gagatgttcg ccgggtgcat gaccgacacg tcgtcggtcg aatgcaccgg
    11461 ctccgtcctc accgctctgt cgcgcatgcg gcccctgctg gaaccggtcg cgcgccgccg
    11521 tgccggacag gcgatggccc gaggcatcga ctacatccgc gcgtgccagc accccgacgg
    11581 gtcgttcagc ggaacatggg gcatcaacta cacctacgcc gccttccacg cagcccgcgg
    11641 gctgcgtgcc gcgggggttc cggccgacga cccggcgccg gtcgcgctgg cccgctggct
    11701 ggaggggtcc cagctgaagg acggttcctg gggcgaggac tggcgaagct gcctcgaacg
    11761 ccggtacctc gcgctggaca caggactgcc cgagatgacg gcctgggcgg tcctggcggg
    11821 gctcgacacc ctcggccccc ggcaccccgt cgtcgagaac ggcatccgct ggctgtgcgc
    11881 ccaccagcaa gcggacggtt cctggaccgg tggccacgtc aacggtgtct tcttcggcac
    11941 gatgatgctc gtctaccacc tctacccggt gtacttcccg gccctggccg tcggccgcta
    12001 cctgcgggcc gtcgccctgt ccgctccctc gaccaccgcc gagccggtcg cgtccgaagg
    12061 acccgcagga cccgatggac ccgcaggtgc accatgacca ccgacgcgca ggctgccgca
    12121 cagcccggag gacggaacct ccccaaggcc gacggggggc tgccggtgat cggtcacgcc
    12181 atccccttct tccaggaccc cgtgggcttc ctgttgcgcg cgcacggcag gcagggcgaa
    12241 gccgtgacgt tctcactgcc gggccggcgc gtggcctcgt tctgcgggcc gcaggccaat
    12301 gccgtggtcc tgagcctgga tgacaccgaa gcggaccgcc gtcccgtcta cgagccgctc
    12361 ctggccccct tgctgggccg gggagtgggc ttcaacgccc ccgccgatgt catgacgtgg
    12421 catcactccc tgctgctgcc ccatctccgg cgggacgccc tgacccggca cgccgcgatc
    12481 atgttcgatc agatggagcg gtacgtcgcc ccgtggaacg gggacggcac gttcgacctc
    12541 atggcagtga tgcgcgacat caccgcgcgc atctcagccc actgcctgat cggaccacgg
    12601 ttcggccgga cgctggcccc ggtgctcccg gcgctgctga gccggctgga agcctccttc
    12661 ttcatgtcct tcgcgatcgg cccccgcccc ttcctgcccc accaccgccg ggccgaccgc
    12721 gcccgtgaga ccctcacccg tgccatcaag gagatcgctc cccgcgaccg ccccgagggc
    12781 aagaagcgca gccatttcga ggagctcatg cgtgccgagg gcccggacgg ccgttccctg
    12841 gacgaagaga ccgcggccgc cctcatgctc tcctggctgt tcgccgcggt tcccatcacg
    12901 atccatgccg cctggaccgg agtgcttctg ctccagcacc cccagtggct tcccgtcctg
    12961 cgcgcggagc aggagagcgc cttcacggac tatccgccga ccacgctgtc cccgctccac
    13021 aagctcgagc gcctgggcca ctgcctcctg gaggccgagc gcctccaccc ggccatctgg
    13081 ctgctccccc gcctggccgt acgagacctg tgcatccgtg gctaccgggt cccgcgcggc
    13141 tacctggtgt gcgcctcgcc gggagcgtcg catcgcctgc cggacgtgtt ccgcgacccc
    13201 ggggccttcg atcccgaccg ctaccttccg gaccagtacc ttccggatcg tacggaacac
    13261 ggcactgctc accacgccct gatcggcttc ggcggaggcc gtcacccctg cctgggcccg
    13321 gccttcgccc agcaagcgat caaggtgatc tggagcgtcc tcctgcgcgc cttcgacctg
    13381 gagctcgccg gtcccgacgt ccgcgaggtc cgcgcctcgg tgttccaccc tccccggcag
    13441 ccgtgcacgg tgcgctaccg ccgcaggaaa cgctgaccac cgatgagccc gccatgcgac
    13501 gtcgcggtca tcggcgcggg cccggtcggg tgcgccgccg cactcgccca cgcccgcgcc
    13561 ggccaccgcg tcctgctcct ggaggcctcg cgccggccgc ccacgcggct ggccggggag
    13621 tggatccacc ccggcggagt cgccgtgctg cgcaggctcg gcgtcggcac gcccgcgccc
    13681 tccttcctcc cggccctggg cttcatcctg cacccggagg acagcagccc gccgatcacg
    13741 ctgccctgcc cgcgcggcga ccgggccgcc accgcacgcc actgcgagct cgtcgccacc
    13801 ctccgggccg tcgcggcgga cgaccccgcc atcaccctcg ctctcggcac gcgtatcacc
    13861 tcgatccggc ggaccacggt cacctacacc cgcgagggcg gacccgagcg gcacgcgcgc
    13921 gtgtggcgcg tcgtcggtgc cgacgggcag tcctccgtgg tgcggcgtac gatccactgc
    13981 gccgcgccgg caacgaccgt ctcgcgcacg gccggtgtgc tgctgcgcgg cctcgctctc
    14041 cccgcagagg ggtacgggca cgtcttcgcg ggcggccccg gccccgtact ggcctaccgg
    14101 ctggacgacg acaccgtccg ggtgaccgtg gacgtccccc tgtcacgtcg gcgcgccgcg
    14161 gaactgccgt cctacgtacg gcgcgtctac tccccgttcc tccccgccga cctggccggg
    14221 ctcctctgca cggccctgga acggaaggag gcggtgcagt gggccgccaa ccgggtccgg
    14281 ctgcgcacct tccacggccg ggagccccac gtcctggtcg gtgacgcggt cggcacctgt
    14341 cacccgctga ccgcctcggg actgaccatc ggcctgcgcg acgccgaatg cctcgccggc
    14401 accgaggacg tcaccgctca cggccgacgc cgacgggccg cagtgcggcc gcacgaacac
    14461 ctcgctgccg ccctgcaccg catcttctgc gacccgggcc ggaccacgag ggatctgcgc
    14521 cgcagcatgt acgccgtcct gcgcgccagc ggcacggaac gcgaacgcat gatgcggctg
    14581 ctgtgcgcgg aagagctggg ccccctcccc ctgacgggcg ccgtcctgca cgtggccggt
    14641 cacgccctgc acgaacaact cgtgacgggc cggtgccgca cgaacccatg gcgcacgtcc
    14701 gtacaggcct gcggggacta cctcggctgg ctgcggtgga tgagccgtcc cccggggcac
    14761 ggctggggca agtgatatgg ggcaagtgat atggaagcgg ggacggatgc cgccgcccct
    14821 ccgaccggcg gcgggtgccg acccggccgg ttcagtagac gaacgggaac atccggaacc
    14881 tggcgcggcg gcagtactcc tcccaaagcc ggccgtactt gacgcggcag cggcggtcgt
    14941 cacggtgcgc ccggtgcacg aacatcagca gcaggaaggc cgggagcagg tacggaacga
    15001 cggagccggt gccgcacagc agcgtccagc tgaggtacac cagcagttcg ccggtgtagt
    15061 tcagctttct gccgatgccc cagaacccgg acaccaggag cctgccgccc agtgtctcgg
    15121 ccggacggcc ccaaatggtg acggcgccac cggtcttgaa gcggtgcttc tggtcgttcg
    15181 ctccgcggaa gagccagaat ccgaagacga acaacgcaca gcacaccgct cccagccaca
    15241 ggggaagggg ctcccggacg tggatcagcg tgcgtccgga gatgccgtag aagaacggca
    15301 cgagaacgta gtccccccac accagcatcc atccgaacct ctcggcgatg aggtcccacg
    15361 tgtggaccat gccgccttcg aactggaaat agttggccag gtagacgaag aagaagatct
    15421 gatagagcag catccggccg ctcaacgaac cctgacccgt gtattggaca gccgcggccg
    15481 acacgttgaa cacgaagagc ccgatgagtg agggccggta ggagaagaac ttcaggtcga
    15541 cccctgccca tacggggttc ctctccactc cgtagaagta gtcactcagg ccgcgccgcc
    15601 gtccggacgg gccggacgcg gccggcgtcc ggcgccggcc ggtgcggaac agcagccagg
    15661 ccagtgcgaa cgcgaacgca ttggccacca gcaggagttc tccccagtgc cggtccggcc
    15721 agacgagcac ccgcggtgac cagatccaga atcccgccgc ggcgcccgcg gtcagcgcga
    15781 agagccaggc accgttgagg cggtaggccc gcggaggctc cgtctccgta tccgtatccc
    15841 ccgccgccgc caggtcttct gtcgccgccg ccggcaccga ccgtccggga atccagcggg
    15901 aacccgcgaa cagcaccagg acgaaagcca ccagcacgaa atccatcagg gcgagagcag
    15961 ccatgaatgc gaatctttct gtggatgtgc cacggctacc cggcaagcgg atggggaaaa
    16021 cgccgcccgc gcgccgttcc accgaaagcg cgacatggcg gctcaacccc ggattcccgg
    16081 gtagcccttg agggcgataa cccggtaact ccgaatgaac cagtggattc cctggaccgg
    16141 ttgacttccc tcacacgagg atgcgcccgt gcaccgtcgg cacagcgttc gcggcaaggc
    16201 cgcagcccgg ggtgtgctgc gtctcctcgg agcggtcgcc cggtggcgtc cccggcacag
    16261 ggcttccctc accgtggtcg cgtgcgttgt cgctacggtg gcgatgggct tgttcggcgc
    16321 gggcggcctg gaccggctca gcaacacctg gccggtcccg atcggatccc gcgccgcccg
    16381 ggacagcgcc gcgctcgggg agcgctacgg cttctccggc cctgatctgg tgctgctgct
    16441 gagcaccacg tcggacgtac gctcgccgga ggtcgcggcg gcgggccgtg cggtggagga
    16501 ggaggtccgc cggtcgccgg gtgtcggggc cgtctcctcg tactggagcg cgaacgaccc
    16561 cgcgctgatc tcccgggacg cgcgttccgc actggtttcc gccgacctga ccggtgagga
    16621 ggccctcagg gccggggccg cacggcggct cgtcgccgcc ctcggcgaac accgcgggcc
    16681 gctgacgatc acgcccaccg gggcggcgtg gacccttgaa gagatcctgg aggacaaccg
    16741 tgccgatctg ctcagggccg aactgatctc cgcgccggcc tgtgccctca tcctcctgtt
    16801 cgtcttccgt tccctcgtcg cggcgctgct gcccgtcgtc agcgcgctga tcgccacggc
    16861 gggcaccctg gcctttctcc ggctgctgac ctccttcacg gaggtctcgg tgtacgcctc
    16921 gaacatcgcc accgccctgg ggctcggcct ggcggtggac tacggcatcc tggtggtctc
    16981 acgcttccgc gaggaatcca cggccggcgt gtccctgcgg gaggccgtcg agcgcagcgt
    17041 ccgcacggcg ggccgtgcgg tcgtcgtctc ggccggcatc gtactggcat gcgtctcctc
    17101 cttgctggtc tttcccttcg tgttcctgcg ctcggcagcc tgggccgccg tcgcggtggt
    17161 ggtgttctcg gcagcggctt ccgtgatcgt cgtccccgcc ctgctggcac tcctcggccg
    17221 gaacaccgac cggttcgacc tgttcgcccg cctccgtagg cgcaactctc gcgggcccga
    17281 gggcagcccg ggctggcgcc gggcgacgct ggccgtcacc cggcggcctg tcgtggcggc
    17341 gctcgccgcc gcctgcgcgc tcaccgcaat gtccctgccc gcatggcacg tctccctcgg
    17401 accgagcggc gtcgacgatc tcccgcaccg cagcagggcc cgtacggcgg cagtgatcat
    17461 ccgtcaggac ttcgcctcgg cgccggagcg agagctgatc gtcgggctgc cgaaagggac
    17521 accgcgcgag gaggtcgagg gccgtgcccg cacggtgtcg gcactgccgc agacggcctt
    17581 cgtccgcacc ttcaccggcc ggtaccgcgg gggcacgaag gtcgaggcac caggcccttg
    17641 ggacacacgg caggatgcac cggccggccc ggtgatggtc gtcgcttcac gctttcctcc
    17701 tggtacggag cgatcggcgg tcctggtgcg gcagctgcgt actctccctg cccacggcca
    17761 cgttctcgtc gccgggcggg cggcagaggc ggtggactcc ctgtccgccg tccggcgggc
    17821 cctgccgtgg tgctgcggcg tcgtcgcggc tgcgacgttc gtgctcatgg cgctgttcac
    17881 ccgcagcttg ctggtgccgt tcaaggccgt ggtggtggcg gcgatgagcc tgggggccac
    17941 gctgggctgc ctggtgtacg tgttccagga cggccacctg cgaagtgtcg tcggcgactt
    18001 ccacgccccc gggtacctca gcgacacgac gaccgtcttc ctgctggcga ccgcgtacgc
    18061 gctcgcggtg gactacgagg tcttcatcgt cgcccgcatc agggaggagt tcctggcctc
    18121 gggtgacaac accgcggccg tcgtcgcggg aatgcagcga acgggccgcc tggtcacggc
    18181 ggcctcactc gtcttcgcag ccgccatggc gggccccgcg acctccggcg tcacctcgct
    18241 caaactcacc gggacgggcc tggccctggc tgtcgtggtg gacgccgtgg tggtgcgggg
    18301 ggctctggtt cccggcctga tgactctggc gggcagggcg aactggtggt tgccgagggg
    18361 ctggaggcgg cgttctcggc ggacagccgg gcgcgcgaac ggtagtgaca tgcgtaagcc
    18421 atgaagcacg gtgcggccag gcggagcgga cgggcggtga cgcgatcatc caggacgcgg
    18481 ggagagcggt agtgccgacg gtcatgacgg catcctcgca cgcgctcttc gcccgcgctc
    18541 ctgatgagtg ggcggccgcc aactgggtgg cgtctcatcc gttctgacgt gctggaacat
    18601 tcttacttga cttgtgggta acttttcggt gatcttactc gcatccacgc ggacgctttg
    18661 agcgcgcgac cgatcaggtc gttgtgccga tgccgtctgc ccgtcccatg gatgaggttc
    18721 ttcatgtctg gattccgcaa cgtttcccgc cttgtttgtt ccgttttatc agctgttgcc
    18781 ttgacaattg ccgtcggctc cactgcctcc gccgcctcgg ccgcctcgac tactgaccgc
    18841 ccctccgcgg tcagcagcgg ctggaacgac tacgactgca agccctccgc cgcccaccca
    18901 cgccccgtcg tcctggtgca cggcacgctc ggcaactccg tcgacaactg gctcgtgatg
    18961 gcgccctacc tggtcaagcg cggctactgc gtcttctccc tcgactacgg caagctgccc
    19021 ggtgtgccgg tcttctacgg cctcggcccg atcgccaagt cggccgaaga gctctccgtc
    19081 ttcgtcgaca aggtgcgcgc ggccaccggc gtcgacaagg tcgacatggt cggccactcg
    19141 cagggcggca tgatgccgcg ctactacatc aacttcctgg gtggcgccga caaggtgaac
    19201 cacctcatcg gcctcgcccc gtccagccac ggcacgacca tgatgggcct gaccaagctg
    19261 atggatgccg tcccgggggc ccgtaaggca ctcggcggca tggcccccgg cctcaccgac
    19321 caggcgctcg gctccgactt cctcaagcgc ctgaacgcca gccccgacac catgcccggg
    19381 gtcgagtact cggtcatcgc caccaagtac gaccaggtcg tcacgccgca cggcacgaac
    19441 ttcctgtcgg gcccgaacgt ccgcaacatc atgctccagg acctctgcgc cctcgacctc
    19501 tccgagcaca tctcgatcgg cagcatcgac cgcatcgtcg tccacaaggt cgccaacctc
    19561 ctcgacccgg ccaacgccga acccaccacc tgcgcgtcgg tcgtgagctg acaccagcgt
    19621 tctcaccggg ccggggcggt gacgccccgg cccggtcgca ccgaagccct gcaggtcgag
    19681 ccgtcggacg agggccgacg ccggcctcag ccttagcctt gttggtgtcc gcagcctcat
    19741 cggcgagcca tcacaagggg accacactcc accggtcgtg cttgcgcatg accacggcct
    19801 tgccgtccgc ggtggtctcg caccctatgc agccctgctc tcgccaggtc ccggatgagg
    19861 tcatcgtccc tcaccgttcc gtcgcgatgt cggccaggca gtccccgccg gttgcgaccg
    19921 cgagcgctca agtctcggac acccaccccg tgaatgcgcg aggccgtgct aggagtgcca
    19981 tcggatagtt gccgccgaag tggcgaggaa gcggcgaggc gaggttgccg gaccgccggc
    20041 agcattaata cggtcaccgc gtggaccagg atgaacggct gcttcacgcc tcgtcgttcg
    20101 gagcagtggc agtcgcatac gccgagcacc gtccggacta cgcgcaggcc gcggtgcgct
    20161 gggcgctcga gcccgtgccc ggaccgcgcg tgctcgacct cggcgccgga accggcaagt
    20221 tgaccaccac gctggtcgcg ctgggtgccg aagtcattgc agtcgagccc gacccggaca
    20281 tgctgaccga gctgcgccgc tcgctgccgg ccgtccgtgc cctgccgggt cgtgccgagg
    20341 cgataccgct gccggacgct tccgtcgatg ccgtgctggc gggcaacgcc atgcactggt
    20401 tcgacatggc cgtcgcggga cccgagatcg ccagagtcct cgcacccggc ggcgtcctgg
    20461 tcggcctatg gaacctcatg gacgaccagg tcgagtgggt tgcccggctc gcgcgggtca
    20521 gcgggaacgc agccatcggc ccacgcgaca cgcccgccgg ctggcgcgcc gcgacggcgg
    20581 acatgcacct tccaaagact gttgcggccg cccggttcgg ctcaccggag cagaccgagt
    20641 tcccccacgg gcagccccgc accgccgact cactcgtcgc gaccatcgcg acgcgcgcgg
    20701 gggtgctcgt catgccagga caggaacaag aggccacact gggacggatc cgggcattcc
    20761 tcgccagcga acctgaggcc gcccgcggcg agttcactct ccccatgctg accggcgtgc
    20821 tgcgcatccg gcggctgtga aacatcacgt cgacaaccga gcccaagggc ttggtcacct
    20881 gagaagtgcc tcaggccggt gcgggaacga gtgcctcgac aaccctcata ctcactggtt
    20941 cagctgagcg ggccgcctgc cggacagccg tttcgtgaag gcgcggggct aagccctcaa
    21001 cgggccggaa ccttctgtgg gttcgtaccg taggcgttct cctgcggctt ggcggccgcg
    21061 gcccagaaca cgatcaggac gatgaggccc acgatcggaa tcaggccaat cagtagccac
    21121 cagcccgacc ggtccgtgtc gtgcaggcgc cggacgctga cagcgaggct gggcaggagc
    21181 acggcgacgt cgtagacggt ttcgatgatg atgcccgtgc cgagcagaac gtcgatgacg
    21241 gccagcacga tgctgacgac aaggctgatc agagtgaaca tccagaactc ggggcggctc
    21301 gcccgtccgc tgaacgtcgc gtatttcttg agtacatcca cataccagtg cacctgcgcc
    21361 cccaagagcc gcggctggcc cgtccacacg gaccgggcct catcccgaac gtaggtggct
    21421 caaagaggtc ggtcaacggt cgtgaggatg cgggcaacag cgccagcaga gcgctccggg
    21481 gctcctgcgt gcgcgcatgg gcatacacga gcccccgtgc aggcagcgtg gccctcgggc
    21541 cgcgccggga gtcaccgtag gccgcaacgc gtgcagctgc tggtcgtcct tactggacat
    21601 cggtgatccg gccttccccg ccgggcgcgt ccgtggtcat aaagcaaacg ttcgtcacgc
    21661 cgagcccggg cgaaggccga cctccgggat ccatccgggt cgccgaccgc acgtccggcc
    21721 agtcgcgctt caccgtgctc gggttgtcac ctcctccggg cctggcgcgg agccggcgac
    21781 ccgcaatggc ggggaccctg cgttaccccg caggacttca ccttcgcagc gcgaacggct
    21841 cgcataggcg tgtaggaggc agcgggccgg gtgcggtatc gggccgcttc agggcgactt
    21901 ccgaacagat cgtggatacc tgatccgccc ggcgggtcga ctcctctagc cgctccggcc
    21961 ttgtggccga cattctcacc tgttcgaaga tgccggaccc tgacggcggc cgaagatcgg
    22021 gggctgagga accgaccggc cgcgacggcc gcggtccctt tgtggcgcag cctcgccggt
    22081 ttcgaaaagt gcgtggg
//
