LOCUS       NZ_CP040272            22613 bp    DNA     circular CON 31-AUG-2024
DEFINITION  Nostoc sp. C052 chromosome, complete genome.
ACCESSION   NZ_CP040272
VERSION     NZ_CP040272.1
KEYWORDS    RefSeq.
SOURCE      Nostoc sp. C052
  ORGANISM  Nostoc sp. C052
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
            Nostoc.
REFERENCE   1  (bases 1 to 7828336)
  AUTHORS   Li,F.-W.
  TITLE     Complete genomes of symbiotic cyanobacteria from bryophytes provide
            new insights into the evolution of Vanadium-type nitrogenase
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7828336)
  AUTHORS   Li,F.-W.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-MAY-2019) Boyce Thompson Institute, Boyce Thompson
            Institute, 533 Tower Rd, Ithaca, NY 14853, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.4.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 84.0x
            Sequencing Technology             :: Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013393905.1-RS_2024_08_31
            Annotation Date                   :: 08/31/2024 08:18:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,527
            CDSs (total)                      :: 8,409
            Genes (coding)                    :: 8,174
            CDSs (with protein)               :: 8,174
            Genes (RNA)                       :: 118
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 104
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 235
            CDSs (without protein)            :: 235
            Pseudo Genes (ambiguous residues) :: 0 of 235
            Pseudo Genes (frameshifted)       :: 84 of 235
            Pseudo Genes (incomplete)         :: 168 of 235
            Pseudo Genes (internal stop)      :: 38 of 235
            Pseudo Genes (multiple problems)  :: 50 of 235
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:15:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3922220
            Orig. end                         :: 3944833
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040272.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Fay-Wei Li, Boyce Thompson
            Institute, 533 Tower Rd., Ithaca, NY 14853, USA.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22613
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="14"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22613
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22613
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12613](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12613)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            158..1240
                     /gene="psbA"
                     /locus_tag="FD723_RS16105"
                     /old_locus_tag="FD723_16060"
     CDS             158..1240
                     /EC_number="1.10.3.9"
                     /GO_component="GO:0009539 - photosystem II reaction center
                     [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="psbA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_045870379.1"
                     /locus_tag="FD723_RS16105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16060"
                     /product="photosystem II q(b) protein"
                     /protein_id="WP_179063885.1"
                     /transl_table=11
                     /translation="MTTTLQRRESANVWDRFCEWITSTNNRIYIGWFGVVMIPTLLAAT
                     ACFVIAFIAAPPVDIDGIREPVAGSLIYGNNIISGAVVPSSNAIGLHFYPIWEAASLDE
                     WLYNGGPYQLVIFHFLIGIFCYMGREWELSYRLGMRPWIAIAYSAPVAAASAVFLVYPI
                     GQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHQLGVAGVFGGSLFSAMHGSLVTSS
                     LVRETTETESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVI
                     GIWFTALGVSTMAFNLNGFNFNQSIIDSEGRVIATWADVINRANLGMEVMHERNAHNFP
                     LDLAAGDVAPVALTAPAING"
     gene            1468..1977
                     /locus_tag="FD723_RS16110"
                     /old_locus_tag="FD723_16065"
     CDS             1468..1977
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010998820.1"
                     /locus_tag="FD723_RS16110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16065"
                     /product="hypothetical protein"
                     /protein_id="WP_179066214.1"
                     /transl_table=11
                     /translation="MILHRGRRVVAALLLSVMILTTACTPKTPGRFDQVQKESTQQKKG
                     LAVAKNATQGSEFNKFFPDSGDGYQRVYTQEKKGFSEAKLKKGGKELALLSISDTTSTP
                     SAAAKFSKSTKKIGGYPAIEVGKTQTAILVGKYQVKALSRDSSFKASDRADWLEKFNLN
                     GLANLK"
     gene            2027..2914
                     /locus_tag="FD723_RS16115"
                     /old_locus_tag="FD723_16070"
     CDS             2027..2914
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012408955.1"
                     /locus_tag="FD723_RS16115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16070"
                     /product="hypothetical protein"
                     /protein_id="WP_179066215.1"
                     /transl_table=11
                     /translation="MSKSIVDLVDQLPTGGLTVSMLKSLDFVAPGEWRNTVGFVNTIKS
                     VTGEDDEDLIQQIGERAIYLFNDKSQGYQTALWLYQTVDSTDKALGAAALANKVGEKIP
                     LLGFLNSVTPKPDKAQTIDLTLKLVAELVAFCQINGIPGDSIGDFVASLGEYSGESLIR
                     MVALVCVDGLIPLGPDFISKAISGLNQTNPQELEQNSTFQSIKDVIPGNNAGSKLNFIG
                     ESFDSVKGWMSGLVSANNLTPQKVVHNLQGFVDIADDKLDYLAAFLDVSTNYYEHTGTQ
                     TLAHRLIERAVAEI"
     gene            complement(2966..3685)
                     /locus_tag="FD723_RS16120"
                     /old_locus_tag="FD723_16075"
     CDS             complement(2966..3685)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012408954.1"
                     /locus_tag="FD723_RS16120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16075"
                     /product="hypothetical protein"
                     /protein_id="WP_179066216.1"
                     /transl_table=11
                     /translation="MLRLYHLLLGSILLVSIPLGAKFVLPQFSSPKAVKPLTVAKLSNP
                     NEGNIWQKILVNAAAPTNWQVAPCEGNAPLLCISSGGKRLGTVEINVYPLANNEDFRKK
                     LVAAGIPTGSQVDYQSSKYQTQVLAALQAWVADHYAAFAKDRQGKYGKEITFSTYPPQP
                     VPIGKLQGIRYGFAGIKQQGGVQEQHIGHVAFDGTKLYVITTAFDTDTQTGKFEKLENL
                     AIFQPYLYAIAADLRLP"
     misc_feature    3684..3698
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.42"
                     /tool="antismash"
     gene            complement(4037..4231)
                     /gene="rpsU"
                     /locus_tag="FD723_RS16125"
                     /old_locus_tag="FD723_16080"
     CDS             complement(4037..4231)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015209218.1"
                     /locus_tag="FD723_RS16125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16080"
                     /product="30S ribosomal protein S21"
                     /protein_id="WP_179066217.1"
                     /transl_table=11
                     /translation="MTQVVLGENEGIESALRRFKREVSKAGIFQDMRKKRHFETPIEKE
                     KRKAIARHKQRRTLRSRFN"
     gene            complement(4356..4667)
                     /locus_tag="FD723_RS16130"
                     /old_locus_tag="FD723_16085"
     CDS             complement(4356..4667)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012408942.1"
                     /locus_tag="FD723_RS16130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16085"
                     /product="RNA-binding protein"
                     /protein_id="WP_179066218.1"
                     /transl_table=11
                     /translation="MSIYVGNLSYQVTEEDLKLAFAEYGKVSRVQLPTDRETGRPRGFA
                     FVEMESDTQEQAAIDALDGAEWMGRDLKVNKAKPREERSSSPRGNWGGGNARRNNNRY"
     misc_feature    complement(4898..4913)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.81"
                     /tool="antismash"
     gene            complement(5062..5919)
                     /locus_tag="FD723_RS16135"
                     /old_locus_tag="FD723_16090"
     CDS             complement(5062..5919)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012408941.1"
                     /locus_tag="FD723_RS16135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16090"
                     /product="3'(2'),5'-bisphosphate nucleotidase CysQ"
                     /protein_id="WP_179066219.1"
                     /transl_table=11
                     /translation="MKDLQEILAIAREVGWGAAEILRSYYHGTAKDPNLEVQYKQNEPV
                     TVADVAVSQYILQSLQATLGNEDFAYISEETYQSSTIATHSAPWVWIIDPLDGTRDFIE
                     KTGDYAVHIALVKEKRPVLAVVAVPETQKLYYATKGGGTFVETRDGSVPLQVSSGKRIE
                     DLTLVVSRSHRNQRLDHLLQNLPSQNHKSVGSVGCKIAALVEQNADIYISLSGKSAPKD
                     WDIAAPELILTEAGGKFTHFDGTPLQYNTGDINQWGGLLASNGEYHELLCQEAEKILAQ
                     FDHS"
     gene            complement(5919..6812)
                     /locus_tag="FD723_RS16140"
                     /old_locus_tag="FD723_16095"
     CDS             complement(5919..6812)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015111800.1"
                     /locus_tag="FD723_RS16140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16095"
                     /product="sugar kinase"
                     /protein_id="WP_179066220.1"
                     /transl_table=11
                     /translation="MDNPKSKIQNPKSDRGLFVGLVTLDLIYLAESAPKSNQKIVATDY
                     TVAAGGPATNAAVTFSHLGNQATVLGVVGSHPMTQLIRGDLANYKVAIADLEPTTDLAP
                     PVSSIIVTQATGERSVISINAVKTQVSSASTPADILQNVNILLIDGHQMAVSYALAQMA
                     KAKNIAIVIDAGSWKPGFEQILPFVDYAICSANFYPPNCETREDVFAYLSGFDIPHIAI
                     THGQNPIEYLSCTKTGIVDVPQIQAVDTLGAGDIFHGAFCHYILRESFTDALGLAANIA
                     ADSCKFFGTRRWMDLN"
     gene            6932..7792
                     /gene="rsmI"
                     /locus_tag="FD723_RS16145"
                     /old_locus_tag="FD723_16100"
     CDS             6932..7792
                     /EC_number="2.1.1.198"
                     /GO_function="GO:0008649 - rRNA methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000451 - rRNA 2'-O-methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsmI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012408939.1"
                     /locus_tag="FD723_RS16145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16100"
                     /product="16S rRNA (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="WP_179066221.1"
                     /sec_met_domain="TP_methylase (E-value: 1.9e-34, bitscore:
                     118.0, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTDPKPGTLYVVGTPIGNLEDITFRAVRILQTVDIIAAEDTRHT
                     GKLLQHFQVKTPQVSYHEHNRTSRIPELLEHLVNHKAIALVSDAGMPGISDPGYELVKA
                     CIEAGIPVVPIPGASAAITALSAAGLPTDRFVFEGFLPSKSQQRQEHLESLQTESRTLI
                     FYESPHRLRDTLQDLAEVWGSDRQIVLGRELTKLYEEFWRGTIAEAIAHYTQREPQGEY
                     TLVVAGIPLSQPQLTEEELIAELKQLISQGISRSQASRQLAKATFLPRRQLYQLALSIV
                     FSPES"
     gene            complement(7967..8827)
                     /locus_tag="FD723_RS16150"
                     /old_locus_tag="FD723_16105"
     CDS             complement(7967..8827)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012411583.1"
                     /locus_tag="FD723_RS16150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16105"
                     /product="phosphate/phosphite/phosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_179066222.1"
                     /transl_table=11
                     /translation="MFLRFPRRLFLFNLLGLTFAACQAKKDKDFEGTLTVGTINYGGGE
                     QIINQYAKFNTYLGEKTNAYIQLEPVFNENRAVERLKSRAWSLVFAPPGLAAIAIARYQ
                     YVPLFPLIGISNLRSIFVVRKDSPITELKQLQGQTVALGQLGSATGYYFPLYNLYGTTL
                     ADILFAPTPKAALEFVAQGKAIACAVSEAELSLYGSQLAPTEFRILFKDPHYVPLGVVL
                     IGPNIELNRQEFIRKVMSDSPSGLAQEVGYVPNGQVPDYKYMISVVDRVSSISSKLQIK
                     PVRLF"
     gene            9040..9954
                     /locus_tag="FD723_RS16155"
                     /old_locus_tag="FD723_16110"
     CDS             9040..9954
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012411582.1"
                     /locus_tag="FD723_RS16155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16110"
                     /product="DUF3365 domain-containing protein"
                     /protein_id="WP_179066223.1"
                     /transl_table=11
                     /translation="MLNKITLNNLKIGAKFNLLLILVFIISILGSGIALSSVLQGRAQN
                     EVTSQAQILIQMVNAVRNYTQNRIDPLLEPRLDTNPTFMPEVVPTFSSKEVFENFRKKP
                     EFKNFFHKDATLNPTNLADKADNFETQLVERFRNEPNTLEITGFRKLSEGEVFYIARPL
                     KITQEKCLRCHSTPDQAPKSQLVNYGSENGFGWQLNQIVSAQIISVPSQEIFANAKRTW
                     ILIMGLLITIFAIVVFLINFLIKKYVIQRIRRIEKIAQKVSVGDMSADFEESSNDEIGG
                     LAEAFNRMKASLKIAMEMLNSQS"
     gene            complement(10001..11098)
                     /gene="pqqE"
                     /locus_tag="FD723_RS16160"
                     /old_locus_tag="FD723_16115"
     CDS             complement(10001..11098)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019497265.1"
                     /locus_tag="FD723_RS16160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16115"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_179066224.1"
                     /sec_met_domain="PTHR43273 (E-value: 5.6e-38, bitscore:
                     129.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.7e-25, bitscore: 87.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.4e-05, bitscore: 24.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 9.9e-07, bitscore: 27.0,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.1e-11, bitscore: 42.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.5e-11, bitscore:
                     40.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIDRPLSLIAELTYRCPLRCPYCSNPLNYGDRQYRQELSTEDWL
                     RVIQQASDLGVLQLGLTGGEPLVRKDLELLVAAAAKAELYTTLITAATLLTPERATQLR
                     DAGLDHVQISIQDSRAAESDYIAGTPSFQQKLEAARLVKSLGFPLTLNFVLHRQNLDRI
                     DEILELCEVLKADRVELANTQYYGWAYRNRTVLLPTCQQLERADAAVALARERNICPMG
                     ILYVLPDYYEDYPKPCMGGWGNRALAIAPNGDVLPCQAASSIPELEFANVRNHSLDWIW
                     FESPAFNRFRGTEWMPEPCQSCDRRQLDFGGCRCQALLLTNNAAATDPVCHLSPHHHLI
                     TTVTKQANQENLDSPLPLVYRSMQM"
     misc_feature    complement(11090..11104)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.3"
                     /tool="antismash"
     misc_feature    complement(11092..11108)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 25.03"
                     /tool="antismash"
     gene            complement(11103..11297)
                     /locus_tag="FD723_RS16165"
                     /old_locus_tag="FD723_16120"
     CDS             complement(11103..11297)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FD723_RS16165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FD723_16120"
                     /product="hypothetical protein"
                     /protein_id="WP_179066225.1"
                     /transl_table=11
                     /translation="MWFIEFGQPFIEFGVWFIEFGQSFIEFGVWFIEFGQPFIEFGVWF
                     IEFGQPFIEFGVLFIIVQF"
     gene            complement(11480..11797)
                     /gene="pqqD"
                     /locus_tag="FD723_RS16170"
                     /old_locus_tag="FD723_16125"
     CDS             complement(11480..11797)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Thurincin_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015122235.1"
                     /locus_tag="FD723_RS16170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16125"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_179066226.1"
                     /sec_met_domain="PqqD_RRE (E-value: 7.1e-23, bitscore:
                     78.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.9e-12, bitscore: 43.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Thurincin_rSAM_RRE (E-value: 6.7e-07,
                     bitscore: 27.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTIENHARPRLVRGVRLRWDDLRKQHWLLVPEGALKLNSTAAAI
                     LALCNGERTLNAIASELEKQYQDKNVVEDVRDLLSRISKRGLLIVESNSQEAEVSLKTD
                     K"
     aSDomain        complement(11534..11794)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FD723_RS16170_PqqD_RRE.1"
                     /evalue="3.10E-25"
                     /identifier="RREFam006.1"
                     /label="FD723_RS16170"
                     /locus_tag="FD723_RS16170"
                     /protein_end="88"
                     /protein_start="1"
                     /score="78.7"
                     /tool="antismash"
                     /translation="STIENHARPRLVRGVRLRWDDLRKQHWLLVPEGALKLNSTAAAIL
                     ALCNGERTLNAIASELEKQYQDKNVVEDVRDLLSRISKRGLL"
     aSDomain        complement(11540..11701)
                     /aSDomain="Thurincin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a thurincin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FD723_RS16170_Thurincin_rSAM_RRE.1"
                     /evalue="2.90E-09"
                     /identifier="RREFam019.1"
                     /label="FD723_RS16170"
                     /locus_tag="FD723_RS16170"
                     /protein_end="86"
                     /protein_start="32"
                     /score="27.8"
                     /tool="antismash"
                     /translation="EGALKLNSTAAAILALCNGERTLNAIASELEKQYQDKNVVEDVRD
                     LLSRISKRG"
     gene            complement(11894..12613)
                     /gene="pqqC"
                     /locus_tag="FD723_RS16175"
                     /old_locus_tag="FD723_16130"
     CDS             complement(11894..12613)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015122236.1"
                     /locus_tag="FD723_RS16175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16130"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_179066227.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.5e-93, bitscore:
                     311.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLELVKEPLPWTQTELEAVLRSQHRRYHHLHPFHARMNSGDLTPT
                     EVRRWVANRFYYQKSIPLKDAAILSNCTDLEVRREWIQRIIDHDGQGDNEGGIEAWLKL
                     GKAVGLSRQELLEDQHVLPGVQYSVDAYVNFCRTKPWIEAVAASLTELFGPDAIRVRLV
                     ALEEHYPWIDPAGFDYFRARLHQAPRDAQYALKQVLKHCKTRDSQERAVQALVFKCNLL
                     WSQLEAIEQGDTRPQEG"
     gene            complement(12636..13541)
                     /gene="pqqB"
                     /locus_tag="FD723_RS16180"
                     /old_locus_tag="FD723_16135"
     CDS             complement(12636..13541)
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015122237.1"
                     /locus_tag="FD723_RS16180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16135"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_179066228.1"
                     /transl_table=11
                     /translation="MFLKILGTAAGGGFPQWNCNCPNCQAVRTNRAGVNWLNQSSIAVR
                     KNNQPWFLVNASPDVRPQLEKLREGQPSTIRSSPIAGVLLTDAEIDHTTGLVILRESTE
                     KLRVYGTETVRKALTEGYPLLSTLANYCGVQWSVLEPHVPINLGLDGADGLEVEVFPLA
                     AKPPKYMRHQTNLDGVWVIGLTFRDRTTGKVATYAPGLAELDEKILERFESSDCILVDG
                     TCWENDELLALGISNLQARDMGHLPLNTSLKSLAKLSRPRKILVHINNTNPILLPDSEE
                     RKIVEAAGIEVGYDGLTIEL"
     gene            complement(13597..13788)
                     /gene="pqqA"
                     /locus_tag="FD723_RS16185"
                     /old_locus_tag="FD723_16140"
     CDS             complement(13597..13788)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: protein motif:HMM:TIGR02107.1"
                     /locus_tag="FD723_RS16185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16140"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_179066229.1"
                     /transl_table=11
                     /translation="MIRETNNHSTQEQESNSSKLSEDVSTRTSFHPPNIKSAIDWEKPD
                     FDELDLCMEITTYILHGQ"
     gene            complement(14597..15952)
                     /locus_tag="FD723_RS16190"
                     /old_locus_tag="FD723_16145"
     CDS             complement(14597..15952)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012411581.1"
                     /locus_tag="FD723_RS16190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16145"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_179066230.1"
                     /sec_met_domain="Pkinase (E-value: 3.5e-39, bitscore:
                     133.3, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGQLLDGRYQVLQVLGGGGFGQTYIAQDTHRPGFPKCVVKHLKP
                     VSRSPEFLETARRLFSSEAETLEQLGNHDQIPRLLAYFEDNQEFFLVQEFIEGHTLKAE
                     LLPNQPWTENQVIQLLQQVLGILQFIHSHNVIHRDIKPDNIIRRQQDGKLVLIDFGAVK
                     QVQTQLLTIPGQTGATIIIGTPGYMSTEQGQGKPRPNSDIYSLGIIGIQSLTGVHPINF
                     EEDPDTGEISWQHQANVSFGLASVLSKMVLHHFKQRYQSAAEVLQVLAQSLQTPSFTQP
                     PQASLSQPNSIGYSSASILSAENYNRLETILLEFVGPVASRLLRQVSASASNFEELVSQ
                     LALYLRENQQIDFKKKTMFLLEKPTLLQELTTKIEIKSNNLPIQEPQEISDSFVNQCER
                     ELANLIGPIAKFIVQKAVKSSGHISRAEFVKVLASQIPEPQKALQFEQRLLS"
     gene            complement(16119..16442)
                     /locus_tag="FD723_RS16195"
                     /old_locus_tag="FD723_16150"
     CDS             complement(16119..16442)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012411580.1"
                     /locus_tag="FD723_RS16195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16150"
                     /product="DUF4278 domain-containing protein"
                     /protein_id="WP_179066231.1"
                     /transl_table=11
                     /translation="MKLYYRGLSYEYDPNKAGSNKTQQPFQPVAQIGPAYNLMYRGVNY
                     PVDPNTKSAELPITPVSYKLSFRGITYFVNKTSLGEVSVASQPGTTSKIETLPTSKELK
                     LQQ"
     gene            16719..16973
                     /locus_tag="FD723_RS16200"
                     /old_locus_tag="FD723_16155"
     CDS             16719..16973
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010997083.1"
                     /locus_tag="FD723_RS16200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16155"
                     /product="hypothetical protein"
                     /protein_id="WP_179066232.1"
                     /transl_table=11
                     /translation="MARTANEYAVFLLLESGHREEVRFPTIQEFQKWYSGELVPKSASN
                     DFISVPIKNIQGEYMVIRPSRIVAIRVEPVFSSSVERFN"
     gene            16977..18227
                     /locus_tag="FD723_RS16205"
                     /old_locus_tag="FD723_16160"
     CDS             16977..18227
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009454197.1"
                     /locus_tag="FD723_RS16205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16160"
                     /product="murein transglycosylase A"
                     /protein_id="WP_179069169.1"
                     /transl_table=11
                     /translation="MRKTLAFLSLSLGIALVNPLWTAVAQVPNLLPLPIPTTPDFSPIP
                     IPITPEVTPPLKPIAIGSNCTLRQTCLGWDEQLWGQKGDRNALLASIDNSLLYLTKSEA
                     IAAYQNYPMREITLDRVRRSLVRFRQLVVSSKSAAQLQAAVRREFVFYQSVGNDGKGTV
                     KFTAYYEPVYTASRVRTAIYKYPLYRLPPDFSQWPKPHPKRIDLEGKDGLQGNKSKLRG
                     LELLWFRDRLDAYMVHIQGSAQIKLTNGKTTSVGYAGGTDYPWTSIGKEIAKDGKLPLN
                     GLTLPRMVAFFRAKPQELSNYLPRWERFIFFQETGGTAATGSIHVPVTAERSIATDKSL
                     MPPGALALIYNSFPYPAGRGKLENRTVSRFVLDQDTGSAIKGPGRVDYFMGSGKLAGDR
                     AGITGGNGSLYYLLLKE"
     gene            complement(18299..19168)
                     /locus_tag="FD723_RS16210"
                     /old_locus_tag="FD723_16165"
     CDS             complement(18299..19168)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011319296.1"
                     /locus_tag="FD723_RS16210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16165"
                     /product="DUF5895 domain-containing protein"
                     /protein_id="WP_179066233.1"
                     /transl_table=11
                     /translation="MKASANFDFEDEKFNAPPSQVLPWCQMINPRYGTDGIQSHGLAIK
                     LDNANAVGFVPDENWQQVEHEFTSGVETVFITPTPRLVIVRRGPLSVKDRESGLKLGTL
                     KENYDAFLADKLKFKTFTRYLIFIVGENKKFLHESPLQLTLNGAAGASFSKTYCEYQQG
                     KVVSGFVAELEKAYAVYRKQPLAPKGPLFHAHGIFCPIIECEERGIEPNTVLVASTVDY
                     KHPTVGTLTQYLIASDALESAMICKTFEEYKDFGKEPIKSETPKLAMAGVSNSYVYADE
                     DDFAYPPY"
     gene            19629..22088
                     /locus_tag="FD723_RS16215"
                     /old_locus_tag="FD723_16170"
     CDS             19629..22088
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012408251.1"
                     /locus_tag="FD723_RS16215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_16170"
                     /product="GH116 family glycosyl hydrolase"
                     /protein_id="WP_179066234.1"
                     /transl_table=11
                     /translation="MTNQLSPKIPSCTWKRPIGLGWDKPYTVRYASNIDDGPWHGMPLG
                     GFGAGCIGRSSRGDFNLWHIDGGEHTFKNVPACQFSVFESNGTSSQAYALSTQAPDDGT
                     LKAWQWYPANNKAEGQRGRGAEGQEEIFSISNTGTYHALYPRSWFVYENVFQAQLTCEQ
                     FSPIWAGNYQETSYPVAIFLWNAHNPTDAPITLSIMLTWQNMVGWFTNALKSPQVRVRD
                     DGSPVYEYQPRWGESQGNYNQIVENTQHFGCVLGRVASDEALQEGDGTWCIATLKHPQV
                     EIFHHSRWNPEGTGEEVWQSFAEDGSLPNYLDATPAVNNTQLGAAMALRFTLQPGETLE
                     IPFVLAWDLPITEFAAGVNYYRRYTDFFDKSGNNAWAIASTALQEYQNWRSQIQAWQKP
                     ILDREDLPNWFKMALFNELYDLTSGGTLWSAASELDPIGQFAVLECLDYRWYESLDVRL
                     YGSFALLMLFPELEKSVIRAFARAIPQGDDTPRIIGYYMTIKAESPIAVRKVAGATPHD
                     LGAPNEHVWQKTNYTSYQDCNLWKDLGSDFVLQVYRDFLLTGADDVEFLADCWNAIVQT
                     LDYLKTFDLDRDGIPENSGAPDQTFDDWRLQGVSAYCGGLWLAALEAAIAISDILLTYQ
                     TGNTTELAVQKSIYETWLKQSRPIYDEKLWNGKYYRLDSESGSDVVMADQLCGQFYARL
                     LDLPDIVPSDRALSALKTVYDACFLKFCNGEFGAANGVRPDGSPENPQATHPLEVWTGI
                     NFGLAAFLVQTGMKDEALKLTQAVVQQIYDNGLQFRTPEAITAAGTFRASTYLRPMAIW
                     GIYLVIN"
ORIGIN
        1 ttctgactcc tgaattctgc ttgataagca aaactaataa cttgtatcag gtttactgaa
       61 gtaacaaaag ttgattaaaa attgtaaagc agtgtaaagt agttccacag gcaaagactt
      121 taccgcctga ttcataaaca accgcaatca taaaacaatg acaacaacct tacaacgtcg
      181 cgaaagcgcc aacgtatggg atcgattctg cgaatggatc accagcacca acaaccggat
      241 ctacatcggt tggttcggcg tagtcatgat ccccaccctg ctagcagcaa ccgcttgctt
      301 cgtaatcgcc ttcatcgccg cacctccagt agacatcgat ggtatccgtg aaccagtagc
      361 aggttcctta atttacggaa acaacatcat ctctggtgca gtagtacctt cctccaacgc
      421 tatcggcttg cacttctacc caatttggga agcagcttcc ttagatgagt ggttgtacaa
      481 cggcggtcct taccaattgg taatcttcca cttcctgatc ggcatattct gctacatggg
      541 tcgtgaatgg gaactatcct accgcttagg tatgcgtcct tggattgcga tcgcttattc
      601 tgctccagta gcagcagcca gcgcagtctt cttggtatac cccatcggac aaggttcatt
      661 ctctgacggt atgcccttgg gtatttctgg aaccttcaac ttcatgatcg tgttccaagc
      721 agaacacaac atcttgatgc accccttcca ccaactaggt gtagctggtg tattcggcgg
      781 aagtttgttc agtgcaatgc acggttcttt ggtaacttct tccttggttc gtgaaacaac
      841 tgagactgaa tcacaaaact acggttacaa attcggtcaa gaagaagaaa cctacaacat
      901 cgttgcagcc cacggctact tcggtcgtct aatcttccaa tacgcttcat tcaacaacag
      961 ccgttcactg cacttcttct tagcagcatg gcctgtaatc ggcatctggt tcaccgcctt
     1021 gggtgtcagc acaatggcgt tcaacttgaa cggtttcaac ttcaaccaat caatcattga
     1081 ctctgaaggt cgtgtgattg caacttgggc ggatgtaatc aaccgcgcta acctgggtat
     1141 ggaagtaatg cacgagcgta acgctcacaa cttccctcta gatttggctg ctggtgatgt
     1201 tgctcctgta gctttaaccg ctcctgctat caacggttaa ttttaaagct tcgctaaatt
     1261 aaaaagcgct ctcctgaaaa ggagggcgct tttgcattgg gttaattgcg acgttaagtc
     1321 tgacactgga cacttttttg aagtgcaaaa ttaaaccgct atagttgaga acttaggcaa
     1381 taattatcaa aaagtaaatt ttacgggtaa taattgctag cagcgcagat aattgcctca
     1441 aagctcaact ataaggagaa gccaagaatg attttacacc gtgggcgtag ggtagtagcc
     1501 gctttgttgc tgtcggtaat gatactgaca acggcctgta ctccaaagac acctggacgt
     1561 tttgaccagg tgcaaaaaga aagtactcaa caaaaaaagg gtcttgcagt tgctaagaac
     1621 gcaactcagg gtagcgaatt taataaattt ttccctgatt caggtgatgg ctaccagcgc
     1681 gtctataccc aagagaaaaa aggtttttcg gaagcgaagt tgaaaaaagg tggtaaagaa
     1741 ctagcgctac tgtctatttc tgatactaca agcacaccta gcgcagcagc aaagttctcc
     1801 aagagtacca aaaaaattgg tggttatccg gcaatagaag ttggtaaaac gcaaacagca
     1861 attttggtag gtaagtacca agtaaaagca ctttctcgtg actcgtcatt taaagctagc
     1921 gatcgcgcag attggttaga gaagtttaat cttaatggtc tggctaacct gaaatgagcc
     1981 aaattactga cattaaagat aataaaccct aaataaggag atttttgtga gtaaatcgat
     2041 tgttgattta gttgatcaat tgccaactgg tggcttgact gtttctatgt taaagtccct
     2101 agattttgtt gctcctggag agtggcgaaa tacagttggt tttgtcaaca ctattaagag
     2161 tgttactggc gaagacgacg aagatttaat tcagcaaatt ggcgaacgag cgatttatct
     2221 attcaatgac aaatctcaag gataccaaac agctttgtgg ttatatcaaa ctgttgattc
     2281 tacagataaa gctctgggcg cagcagcctt agctaacaaa gttggcgaga aaattcctct
     2341 gttgggtttt ttaaattctg ttactcctaa acctgataaa gcccaaacca ttgatttgac
     2401 tttaaaatta gtggctgagt tggtagcctt ctgtcaaatt aacggcattc ctggagatag
     2461 tattggggat tttgtcgcct ctttaggaga atatagtggt gagtcactta tccgcatggt
     2521 ggcattagtt tgcgttgatg gtttgatacc tctgggccca gacttcatca gtaaggcgat
     2581 atctggactt aatcaaacaa atccccaaga gttagagcaa aactcgactt tccaaagcat
     2641 caaagatgtg attccaggaa acaatgctgg tagtaaactc aactttatcg gcgaaagctt
     2701 tgactcagtt aaaggttgga tgagtgggtt agtctccgcc aataatttaa cgccacaaaa
     2761 ggttgtccac aatttgcaag gttttgtcga tattgctgat gacaagttag attacttagc
     2821 ggcgttcctg gatgtatcaa caaattatta tgaacacacc ggtacgcaaa ctttagcgca
     2881 tcgcttaatt gaacgggcgg tagctgagat ttaggtggac tggggactgg ggaagaagaa
     2941 aattttaccc aatccccaat ccctattaag gtaaacgtaa atctgcggcg atcgcataca
     3001 agtaaggttg aaaaatagcc aagttttcga gtttctcaaa cttacctgtt tgcgtatctg
     3061 tgtcaaatgc agtagtaatt acgtaaagtt tagtcccgtc aaaggcaaca tgaccgatat
     3121 gttgctcttg tactcctcct tgttgcttaa ttccagcgaa cccatagcgg attccctgaa
     3181 gcttgccaat aggtactggt tggggtggat aggttgagaa ggtaatctct tttccatatt
     3241 taccctgacg atcttttgca aaggcggcgt agtgatctgc aacccaagct tggagtgctg
     3301 ctaatacctg ggtttggtat ttggaacttt ggtagtcaac ttgagaacca gttggaatgc
     3361 cagctgctac aagtttcttt cggaaatcct cattgttggc tagtgggtaa acgttaatct
     3421 caactgtacc caaacgtttc ccgccagagg agatacacag caagggtgca tttccctcac
     3481 aaggagcaac ttgccagtta gttggagcag cagcatttac taagattttc tgccagatat
     3541 ttccctcatt aggattggaa agttttgcaa cggtaagagg ttttaccgct ttaggtgaag
     3601 aaaattgagg gagaacaaat tttgctccca gtggtattga caccagcaaa atagaaccta
     3661 gtaataaatg ataaagtcgt aacatttttt tgaaaatcca gagccaaaga ttgcagacta
     3721 acgatatcta caatacttca tgggtataga atttttttaa cgtagacgca aagcggtgaa
     3781 gcagcgcggt tgggggtttc ccccatgagc gactgctgtt agcgcagcgt aaagccttct
     3841 ctatgagacg ctacgcgaac ggcatggctt cgcttagagc gacgttagga gcgctgaaag
     3901 caaatacagc gctactatga acagtgttgt ttatcgattt atgcctaatt acttgcttgt
     3961 actttgccgg aagtatggca acgatgaaaa gatgctggct aaatttcaaa tcgaagggca
     4021 agcttgctta gactttttaa ttgaagcgag aacgtagtgt acgacgttgt ttgtgcctag
     4081 caattgcttt acgcttttct ttttctatgg gcgtctcgaa atgacgcttt tttctcatat
     4141 cttggaaaat tcctgcttta gaaacttccc gtttaaatct tctcaaggct gattcaatac
     4201 cttcattctc ccctaaaact acttgtgtca ttctcattcc tcctgaatgt ggatgaatag
     4261 tttaagacta gatacaaaat caaatattcc agcagaatga gcctttggct ttatctgctg
     4321 gaagactcta aatgtgaaat tttcaggaac cgactttagt agcgattatt gttgcggcga
     4381 gcgttaccgc caccccagtt accacgagga gagctgcttc tttcctcacg aggtttagct
     4441 ttgttgactt tcaaatcacg tcccatccat tcagcaccat caagtgcatc aatagcagct
     4501 tgttcttggg tgtctgattc catttctaca aaagcgaacc cacgcggccg gcctgtttcc
     4561 cgatctgtgg gtagttgaac acgacttact tttccgtatt ctgcaaaagc cagcttaagg
     4621 tcctcttctg taacctgata ggacaggttt ccgacgtaaa ttgacataga aatctccgaa
     4681 ttcagggagt gtagagagtt aaattcggag agacggtttt tagaaatcaa aactagttac
     4741 tcaaccgaaa ataatcttta tgtccatgag tgtagcacag cctctagcct ttgaatatcg
     4801 tccgatcgtg aattttattg acgaatagaa cctttagtac aggttcgtaa acccaccaat
     4861 gacaggcttt tgttgcttgt actataaaag ttacattttg aacaggaaat cgatattaat
     4921 cagcgatcgc tcaagtatgt agtgttttga aattgacgat atggactaag gacgaagatt
     4981 attattcgta gtcctggtgg ctataccatg actaactgtt ttaaaaacaa aattaaaaaa
     5041 tattcatctt aaaatatccc attaactgtg gtcaaactgc gctaaaatct tttctgcttc
     5101 ctgacacagt aattcgtgat attcaccatt actagccagt aagcctcccc attgattaat
     5161 atcaccagtg ttgtactgca acggagtacc atcgaagtga gtaaatttac caccagcttc
     5221 cgttaaaatc aattctgggg ctgctatatc ccaatctttg ggcgcagact taccagaaag
     5281 agaaatgtag atatctgcat tttgctcgac aagggcggcg attttacagc ctacactacc
     5341 cacagattta tgattttgag agggtaagtt ctgtaataag tgatctaagc gttggttgcg
     5401 gtgcgatcga ctaacaacta aagttaaatc ttcaattcgt ttgcctgacg acacttgtaa
     5461 aggaacagac ccatcacggg tttctacaaa tgtaccccca cctttggtag cgtaatataa
     5521 cttttgagtc tctggtactg ccaccactgc taatactggg cgtttttcct taactaaagc
     5581 aatgtgaact gcataatccc cagttttttc gataaaatct cgtgtaccat ccaaagggtc
     5641 aatgatccat acccaaggag cggaatgtgt agcaatagtt gacgattgat aagtttcttc
     5701 actgatataa gcaaaatctt cgttacctaa agttgcttgt agactctgca aaatgtattg
     5761 acttacggcg acatcggcaa cggtgacagg ctcattctgc ttgtattgta cttctagatt
     5821 cgggtctttt gcagtgccgt gataatacga tcgcagtatc tctgctgcgc cccaacctac
     5881 ctcacgagcg atcgctaata tttcttgtaa gtctttcatt aatttaaatc catccagcgc
     5941 cgtgtaccaa aaaatttaca agaatcagca gcaatattag ctgctaatcc tagtgcatca
     6001 gtaaaacttt cccttaaaat gtaatgacag aaagcaccgt ggaaaatatc tccagcccct
     6061 aaggtatcaa ccgcttgaat ctgcggcaca tctacgatac cagttttagt gcaactcaag
     6121 tattcaattg ggttttgtcc gtgggtaatg gcgatgtgag gaatatcaaa tccactgaga
     6181 taagcaaaaa catcttctct agtctcgcag ttagggggat aaaaattagc tgaacagatg
     6241 gcgtaatcca caaatggcag aatttgctca aatccaggct tccaactacc agcatcaatt
     6301 actattgcaa tattcttggc tttagccatt tgggcgagag cataactaac cgccatctga
     6361 tgcccatcaa tcagtaatat attgacattt tgcaaaatat ctgctggtgt agatgcgctg
     6421 ctgacttgag ttttgacagc attgatggaa atcacagatc gttcacctgt ggcttgggtg
     6481 acaataattg aagatacagg cggtgctaaa tcagtggtag gctcaaggtc tgcgatcgca
     6541 actttataat ttgccaaatc acctcgaatt agctgcgtca tcgggtgaga acccactaca
     6601 cccaagactg tagcttgatt acctaaatgg ctgaaagtca cagccgcgtt ggtagctggc
     6661 ccccctgccg ctacagtata gtcagtagcg acaatcttct ggttactctt aggggcagat
     6721 tcagccaggt aaatcaaatc caaggttact aaacctacaa ataacccacg atccgatttt
     6781 ggattttgga ttttggattt tggattatcc atgtgtcata tatgttcgta attattttta
     6841 actcttgtac agacgcgatg aatcgcgtct ctcttgtctc tcctgcacag acgtgattca
     6901 tcgcgtctct acaaattcct aactcttgct catgcaaacc gatccaaaac caggaacact
     6961 ttacgttgtc ggcacaccaa ttggcaacct ggaagatata acctttcggg cggtgcgaat
     7021 tttacagact gtggatatca ttgcggcgga agacacccgt catacaggga aactgctaca
     7081 gcattttcaa gttaagacac cccaggtaag ttaccacgaa cacaatcgta ctagccgcat
     7141 cccagaatta ttagagcatt tagttaatca taaagcgatc gctctggtga gtgatgctgg
     7201 gatgccaggt atttctgatc ctggatatga actggtgaaa gcctgtattg aggcgggaat
     7261 tccagtagtt cctattcctg gcgctagtgc agcaattacc gctttgagtg cagccggatt
     7321 accaacggat cggtttgtct ttgaaggctt cctcccgtct aaaagtcaac agagacaaga
     7381 acatttagaa tctctgcaaa cagaatctcg cacactaatt ttctacgaat cgccccaccg
     7441 cttgcgagat actttacaag acttagcaga ggtttgggga agcgatcgcc aaattgtgct
     7501 aggacgggag ttaactaaat tgtatgaaga attttggcgg gggacaattg ctgaggcgat
     7561 cgctcactac acccaacggg aaccccaagg tgaatataca ttagtcgtgg caggaattcc
     7621 actcagtcag ccccaactga cagaagagga gttgatagcc gaattgaaac agttaattag
     7681 tcagggaata tcgcgatcgc aagctagtcg tcagttagca aaagctactt ttcttccccg
     7741 tcgccaactc taccaactag ctctttctat agtttttagt cctgagtctt gaagaagaat
     7801 tcagaatggg ctacgccccg ctgcgctaac aggagtcaga atagttaaag aatcagaaaa
     7861 acatttgatg aataaatata ctaattattc tagatttatt ataaattctg aattcagaat
     7921 tctgaattct gaattctgac tcctgaattc tgttttgtta acttcctcaa aataaacgca
     7981 caggctttat ttgcagctta gaactaatcg agcttacccg atcaacaaca gaaatcatgt
     8041 atttgtaatc tggtacttgt ccattgggta cataccccac ttcttgagct aaacctgaag
     8101 gcgaatcact catcactttg cggataaact cttgacgatt aagttctata ttaggcccaa
     8161 tcaagaccac acctaatggt acatagtgcg gatctttaaa tagtatgcga aattcagttg
     8221 gggccaactg cgaaccgtag agacttaatt ccgcctccga aacggcacag gcgatcgctt
     8281 ttccttgagc gacgaattct agcgcggctt tgggtgtggg tgcaaatagt atgtcagcta
     8341 gtgttgtacc ataaagattg taaagaggga aataatatcc tgtggctgaa cctaactgtc
     8401 ctaaagccac tgtttgacct tgtagttgtt tcaactctgt tatcggactg tctttgcgaa
     8461 caacgaagat ggaacgcaaa ttactaatac ctattaaagg aaatagggga acatattggt
     8521 agcgtgcgat cgcgatcgca gctaaacccg gtggagcaaa taccaatgac caagcacgag
     8581 acttaaggcg ctcaaccgct ctattttcat taaagacagg ctctagctga atataggcat
     8641 ttgtcttttc acccaagtaa gtattaaatt tagcatattg gttaattatc tgttcgcctc
     8701 caccatagtt gatagtacca acagttaacg tgccttcaaa gtctttgtct ttttttgctt
     8761 ggcaggcagc aaatgtgaga cctagcagat taaacagaaa taaacgacga ggaaatcgca
     8821 aaaacatcac taattatgct taagaaaaag taacttggac ttcaggagta atttagataa
     8881 gttagataag tttgactact gcctaaatag tttgcattgc agtcaaaaat aaatatttat
     8941 taatatttat ttagatattg ttgagatact ttctaacagg tttaaataaa taaatattaa
     9001 aattaaacaa actcaattat caccttcatt gctgagatta tgctaaacaa aattacgtta
     9061 aataacttaa aaataggtgc taaatttaac ttacttttaa tattagtctt catcatcagt
     9121 attttgggaa gtggcattgc cttatccagt gtacttcaag ggagagcgca aaatgaagta
     9181 acttctcaag cgcagattct catccaaatg gtgaacgcag ttagaaacta tacacaaaat
     9241 cgcatagatc ccctattgga acctagacta gatactaatc cgacgttcat gcctgaagta
     9301 gtaccaactt tttcatctaa agaggttttt gagaattttc gtaaaaagcc tgaatttaaa
     9361 aacttttttc ataaagatgc aacacttaat ccaactaatt tagcggataa agctgataat
     9421 tttgaaactc aacttgtaga acgttttcgc aacgaaccca atactctaga aattacaggc
     9481 tttcgtaaat tgtcagaagg cgaagtattt tacattgcac gaccactaaa gattacacaa
     9541 gagaaatgct tgcgatgtca ttctacacca gatcaggctc ctaagagtca gttggtaaat
     9601 tatggctcag aaaatggttt tggctggcaa ctcaatcaga ttgtttctgc ccaaataatc
     9661 tctgttcctt ctcaagagat ttttgccaat gccaaacgaa cttggatatt gatcatggga
     9721 cttttaatta cgatctttgc gatcgtagtt ttcttaatta acttcttaat caaaaaatat
     9781 gtgattcagc gcatcagaag aatagagaaa attgcccaaa aagttagcgt tggtgatatg
     9841 agcgctgatt ttgaagaaag ctctaatgat gaaatcggcg gattagcaga agcatttaat
     9901 cgaatgaaag ctagcttaaa aatagctatg gaaatgctta atagccagag ctagtaattc
     9961 gtaatgacgc tatattgttg tgaagttctt taatagctga ttacatttgc atggagcgat
    10021 aaaccaaagg taggggtgaa tccaagtttt cttgatttgc ctgcttggtg actgtagtaa
    10081 tcaggtgatg gtgtggtgac agatgacaga caggatcagt ggcagcagca ttgttcgtca
    10141 aaagtaacgc ttggcaacgg caaccaccaa aatcaagctg gcggcgatcg caactttggc
    10201 aaggctcagg catccattct gttccccgga agcgattaaa agcaggtgat tcaaaccaaa
    10261 tccaatctag tgaatggttg cggacgttag caaattctag ttctggaatc gaactggcgg
    10321 cttggcaagg taacacatcg ccattgggag cgatcgctaa agctcgattg ccccagccac
    10381 ccatacatgg tttgggataa tcttcataat agtctggaag cacatataag atgcccattg
    10441 ggcagatgtt gcgctctcta gctaatgcca ctgcggcatc tgctcgttct agctgctgac
    10501 aggtgggtaa taaaacagta cggttgcgat atgcccagcc ataatactga gtgttcgcta
    10561 attcaactcg gtctgctttt aaaacctcac acagttctaa aatctcatca atcctatcta
    10621 ggttttgccg atgcagaaca aaattaagtg tcagcgggaa acccaaagat tttactaatc
    10681 ttgctgcctc tagtttttgc tgaaaagagg gagttcctgc aatatagtct gactcagcag
    10741 cacgactatc ttggatgcta atttgtacgt gatcgagtcc ggcatcacgt agctgtgtcg
    10801 ctcgttctgg agttaacagc gtcgcagcag taatcaaagt ggtatatagt tcggctttgg
    10861 ctgctgcggc cacaagtaat tctaaatctt ttcgtaccag tggttcgccg ccggtcaagc
    10921 caagctgtaa cacgcccaag tccgaggctt gctgaatcac tcgcaaccaa tcttcggtgg
    10981 aaagttcttg acgatactgg cgatcgccat aattaagcgg gttggagcag tacggacaac
    11041 gcagtgggca gcgatacgtc aattctgcaa tcaagcttaa aggtctatca attgtcataa
    11101 aattaaaatt gaacaataat aaacaacacc ccgaattcaa taaacggctg cccgaattca
    11161 ataaaccaca ccccgaattc aataaacggc tgcccgaatt caataaacca caccccgaat
    11221 tcgatgaacg actgcccgaa ttcaataaac cacaccccga attcaataaa cggctgcccg
    11281 aattcaataa accacacccc gaattcgatg aacgactacc cgaattcaat aaaccacacc
    11341 ccgaattcga tgaacgacta cccgaattca ataaaccaca ccccgaattc gatgaacata
    11401 tctttgacat ttgggctttt gccttaactt gacattaatg tcaagacgcc caccccacaa
    11461 gagatagttg gatatttttt tatttgtcag tttttaaact aacttctgcc tcttggctat
    11521 tgctttctac aattaataat cctcgtttac taattcgaga gagcagatcg cgcacatcct
    11581 ctaccacatt tttgtcctgg tactgtttct ctaactctga tgcgatcgca tttagagttc
    11641 gctcaccatt acaaagtgcc agaattgctg ctgctgtgga gtttaatttt agtgcccctt
    11701 ctggaaccag gagccaatgc tgctttctca ggtcatccca gcgtaaacgc acaccacgaa
    11761 ctaggcgcgg tcgagcatga ttttctatag tactcattta attcgtaatt cgtaatgacg
    11821 ctcgaagact cgctaacgct acgctaacgt aattcgtaat taggaaaatc aaagcctcac
    11881 acccctattc tctctaccct tcttgaggtc tagtatcgcc ttgttcaatt gcctctaact
    11941 ggctccataa caaattgcat ttgaatacta aagcctgtac tgctcgttct tgagaatcac
    12001 gagttttaca gtgtttcagg acttgcttga gggcatattg agcatctctg ggtgcttggt
    12061 gaagacgggc ccggaagtag tcaaatccag ccgggtcgat ccacgggtaa tgctcttcta
    12121 aggcaactaa gcggactcga attgcatctg ggccaaacag ttcagttagt gatgcagcca
    12181 ctgcctcaat ccaaggttta gtgcgacaaa agttaacgta ggcatccact gaatattgaa
    12241 ctcctggcag tacgtgctgg tcttctaaga gttcctgacg agacaatcct acagctttac
    12301 cgagttttaa ccatgcctca ataccacctt cgttatcacc ttgaccgtca tgatcgatga
    12361 tgcgttgaat ccattctcgt cgcacttcta aatcagtgca gtttgacaag atcgcagcat
    12421 ctttcagggg aatacttttt tgatagtaaa atctatttgc tacccagcgt cgtacttctg
    12481 ttggcgttaa atcaccactg ttcatcctcg catgaaatgg atgcagatga tgatagcggc
    12541 gatgttgcga tcgcaataca gcctctagtt ctgtctgagt ccacgggaga ggttctttaa
    12601 ctaattccaa cacgcttatt tcttacacct caaaattaca attcgatggt taagccatcg
    12661 taaccaactt ctatacctgc ggcttcaaca attttgcgtt cctctgaatc aggtaaaagt
    12721 attgggttag tgttgttgat gtgaacgaga attttccgag gacggctcag tttagcaagg
    12781 ctttttaaac tagtgttcag gggtaagtgt cccatatcgc gcgcttgcag atttgatatt
    12841 cctaaagcca acaactcatc attttcccag caagtgccat ctactaaaat gcagtcacta
    12901 gactcaaacc gctctaggat tttttcgtca agttcagcta aacctggagc atacgttgca
    12961 actttgccag ttgtgcgatc gcgaaatgtc aaacctatga cccaaactcc atctaaattt
    13021 gtctgatggc gcatatattt tggtggtttg gctgctaggg gaaatacctc cacttccaaa
    13081 ccatctgctc catccaaccc caggtttata ggtacatgag gttcaagtac agaccattgc
    13141 acaccacaat agtttgctaa ggtagacagc aggggataac cctctgtcag agccttacgt
    13201 actgtttccg taccatatac ccgcagtttt tccgtagatt ctctgaggat aaccagacca
    13261 gtggtatggt caatctctgc atcagttaac aagacaccag cgatcggact tgaccgaatt
    13321 gtagacggtt gtccttcccg caatttctcc aactgcggac gtacatctgg agaggcatta
    13381 accaaaaacc agggctgatt attttttctc accgcaattg atgactggtt cagccaattt
    13441 acacctgcac gatttgtacg aactgcttgg caattgggac agttacaatt ccattgagga
    13501 aaaccaccac ctgcggcagt accaagaatt tttaggaaca taaaaacaaa aagcaggtag
    13561 aggttttaat tcggcaatta aactgagtat tgacaattat tgcccatgca gaatgtatgt
    13621 ggtaatttcc atacacaagt caagctcatc aaaatctggt ttttcccaat caattgctga
    13681 cttaatattt ggaggatgaa atgaggttct ggtagagaca tcctcactta attttgagct
    13741 attgctttct tgctcttgcg tagagtgatt attggtttca cgaatcatta gggacacctt
    13801 ttgaaatgaa tgttcagttg ttaatttggc ctgcaattaa ttctagtaat tttacttact
    13861 atttgtctta atttgctggc tcaaaatttc tttgctttag attaaactga gttgcacaag
    13921 aaacacacag tatttttact gctcttttac tattttttat tattttttca tcatccgtat
    13981 cagtaatggt gcgggtgaaa agtcggagag atagtaaaaa accacgagat aatacggagg
    14041 gatgtatctg tgagaatgtt tgaaaagtat tgggcgatat agaataactc tgttggcgaa
    14101 ttgcgtaggc gtaacccacc gtaggtatcg ctatcctcaa aaccttgaga tgtcgtaaca
    14161 tctcacccca gaaattgcag tttaaatgaa ttcactaagc taaaacacat ctaatttgca
    14221 tattaaaatt ttctcaatat cttgtggggt gggcatcttg cccgccctga ttatgcaact
    14281 tgaatgctga ttagcttact acatacacaa agcaaagtcc acctccgtgg actaatacaa
    14341 aatcaagact tctaatcgcc agggctagta actaaattct actcttattc agtccaggct
    14401 caatactgtt cggttaagac cagagacggc gatttatcgc gtctttataa tgatttatcg
    14461 gatctttgcg ctctacaatt tccatcaaaa aaccttaact gaaccgtatt cagtccaggc
    14521 tcaccaataa tatttagatg cgtttgcccg tgcgtaattt gtaatttacg gagagaacaa
    14581 cgcaatattt aaaaactcaa gaaagtaagc gttgctcaaa ttgcaaagct ttttgaggtt
    14641 cgggaatttg tgatgctaaa actttcacaa attctgcacg agaaatgtgc ccagaagatt
    14701 taacagcttt ttgaactata aacttagcta ttgggccaat caaattagcc aattctcgct
    14761 cacactgatt tacaaagctg tcactgattt cttgaggctc ttgaattggt aaattattgg
    14821 acttaatttc aatcttagta gtaagctcct gtaggagagt gggtttctct agtagaaaca
    14881 ttgttttctt cttaaaatca atttgttgat tttctcgaag ataaagggct aattgactaa
    14941 ctaattcttc aaaattggat gctgacgccg aaacttgtcg taataatctt gaggcaacag
    15001 ggccaacaaa ttctaaaaga atcgtttcta agcggttgta attttccgca gacaggatag
    15061 aagcagacga ataaccaatt gagtttggtt gagaaagtga agcttgaggc ggttgggtaa
    15121 aagacggtgt ttgaagtgat tgtgctagca cctgtagaac ttcagccgca gactgatagc
    15181 gctgcttaaa gtggtgtagc accatcttag atagcacaga tgctaaccca aaactgacgt
    15241 tagcttgatg ctgccaagaa atttctcctg tatctgggtc ttcctcaaag tttatcggat
    15301 gtacccccgt cagcgattga ataccaataa tacccaagga ataaatatcg ctgttggggc
    15361 ggggcttacc ttgcccctgt tctgtagaca tatatcctgg ggtgccaatg ataatagtag
    15421 ccccagtttg ccctggaatt gtcagcagtt gagtttggac ttgtttaact gcgccaaagt
    15481 caatcagcac taacttaccg tcttgttgtc gtctaattat attgtccggc ttgatatctc
    15541 gatggataac gttgtggctg tgaataaatt gcagaatacc tagaacctgt tggagcagtt
    15601 gaattacttg attttctgtc caaggttgat tgggtaatag ttctgctttc aaagtatgcc
    15661 cttcaatgaa ctcttgcacc aagaagaact cttggttatc ttcaaaatag gctaaaagcc
    15721 gaggaatttg gtcatggttg cccagttgct ctagtgtttc tgcctcactg ctaaatagcc
    15781 gtctagcagt ttcgagaaat tcagggctac gactgacggg cttaaggtgt ttgacaacgc
    15841 atttcgggaa acctggtcga tgggtatctt gggctatgta ggtttgaccg aatccacctc
    15901 cccctaaaac ttggaggact tggtaacgtc cgtctaataa ttgtcctaac attgtgtcac
    15961 aagccttaag tcctcagatt aatcttggca taactgctag ctttggcaag gttggttgag
    16021 acaaaaacta ggtaggtaat gctaaaattt cgaggtttgt tgagaatttt actacaagct
    16081 catgactccc tagactccaa atcggcttgg agccatattt attgttgaag ctttaattcc
    16141 ttagaagtcg gcagtgtctc aatttttgaa gtagttcctg gttgagaggc tacgctaact
    16201 tctcctagtg aagttttatt tacaaaatag gtgattcccc gaaagctcaa tttatagctt
    16261 acgggtgtta tgggaagttc tgctgatttg gtatttggat caacaggata gttaacgcca
    16321 cgatacatca ggttataagc tggcccaatt tgagcaactg gttgaaacgg ctgttgtgtt
    16381 ttgttgctgc cagctttgtt tgggtcgtat tcgtagctca gaccacgata gtaaagtttc
    16441 atatttttcg gctcctgaat aactcttgtt caacaatgcc aatgacttat cagaggttaa
    16501 ttgaagagtt atgcatgaac taatgtaaac ctacactttt taaggaactg gttaaaggat
    16561 taggcgtcta gagtgaggag taattgggca ttgggtatgg ttattttcct tgtcaccctg
    16621 ctcctctgcc cccaacctcc cgtatgctta cccttttcat tcgggggttg cgtggttaac
    16681 aatgggttga atgtttttta aataaataat tcaactttat ggctagaact gcaaatgaat
    16741 atgccgtatt cctcctactg gaaagcggcc accgggaaga agtgcgtttt ccgactattc
    16801 aagagtttca gaagtggtat agtggcgaac ttgtgccaaa atctgcttct aatgacttta
    16861 ttagcgtgcc gattaaaaat attcaagggg aatatatggt aatacgccct tctcggatcg
    16921 tggcaatccg ggtagaaccc gtttttagtt ccagtgttga aagattcaac taaatgatga
    16981 gaaaaaccct tgctttcctt tccttgagtc tgggaattgc ccttgtaaat cctctctgga
    17041 cggctgttgc tcaggttcct aacttactac cgttaccaat accgactact cctgatttct
    17101 cgcctatacc aataccaatc actcctgaag taacgccgcc cctaaaacca attgctatcg
    17161 gcagcaattg tacgctgcgg cagacttgct tgggttggga tgagcaactt tggggtcaaa
    17221 aaggcgatcg caatgcgttg ttggcttcta ttgacaatag tttgctttac ctaacaaaga
    17281 gtgaggcgat cgcagcatat caaaattatc cgatgaggga aattaccctc gatcgcgtcc
    17341 gccggagttt ggtacgcttc cgccaactgg ttgtcagttc taagtcagca gcgcaattac
    17401 aagcggctgt ccgccgtgag tttgtcttct accagtctgt gggcaatgat ggcaagggta
    17461 ctgttaagtt caccgcttac tacgaacctg tttataccgc tagccgcgtc aggactgcaa
    17521 tatataaata tcctctttat cggctaccac ctgatttcag ccaatggcct aaaccccacc
    17581 caaaacgcat tgatttggaa gggaaagacg gtttacaagg gaataagagc aaattgcgcg
    17641 gtttagaact gttatggttt cgcgatcgcc tagacgcata catggtacat atccaaggtt
    17701 ctgcccaaat taaattaact aatggcaaaa caacatcagt tggctatgca ggtggaactg
    17761 attacccttg gactagtatc ggcaaagaaa tagccaaaga tggcaaactt ccactaaatg
    17821 gattgacgtt accacgtatg gttgcttttt tccgagcaaa gccgcaggag ttgagcaatt
    17881 atctaccacg ttgggaacga tttattttct tccaagaaac tggtggtacc gcagctacag
    17941 gcagtattca tgtgccagtg acggcagaac gttccattgc tacagataag tctctcatgc
    18001 caccgggagc gctagcgttg atttacaact catttcccta tcctgctggt cgtggcaaac
    18061 tagagaatcg taccgtcagc cgttttgtgc ttgaccaaga tacaggaagc gccatcaaag
    18121 gcccaggacg agttgattat ttcatggggt ctggtaaact agcaggcgat cgcgctggca
    18181 tcacaggcgg caatggttca ctatattatc tgctgcttaa ggaataaagt taggagttag
    18241 gagttaggag ttattaattg aaaacttatc actcatcact cctcactcct cactttcttt
    18301 aatatggcgg ataagcaaaa tcatcttcat cagcataaac gtaagaattg gaaactcctg
    18361 ccattgccaa tttaggcgtt tctgatttga taggttcctt gccaaaatct ttgtattctt
    18421 caaaagtctt acaaatcatt gcagactcaa gagcatcgga agcaattaaa tattgcgtta
    18481 aagtcccgac agtgggatgt ttgtagtcta cagttgaagc taccaaaacc gtatttggtt
    18541 caatacctct ttcttcacac tcaatgatgg ggcaaaaaat tccgtgagca tggaacaaag
    18601 gcccttttgg tgctagaggt tgcttacggt agactgcata agctttttct aattcagcaa
    18661 caaatccact aactactttg ccttgttgat attcgcaata ggttttgctg aaactcgctc
    18721 cggcagcacc attaagagtt agttgtaatg gtgattcatg taaaaacttt ttattctcac
    18781 ccactataaa aattaaataa cgagtaaagg ttttaaattt aagtttgtcg gctaaaaaag
    18841 catcataatt ctctttgagc gtacctagtt ttagaccact ttcccggtct ttgacagata
    18901 atggaccccg acgcactata accaggcgtg gagtaggggt aataaatacc gtttcgactc
    18961 cagaagtaaa ttcatgctcc acttgctgcc aattctcatc tggcacaaag ccaacagcat
    19021 tagcattatc tagcttaatc gccaaaccgt gggattgtat gccatctgtg ccataccgag
    19081 gattaatcat ctgacaccag ggaaggactt gagaaggcgg tgcattgaat ttctcgtctt
    19141 caaagtcgaa attagcagat gctttcatcg ttttaggcta tcaaagtgtt ttattgaaca
    19201 agtttatcgg cagggtgctg atcctgggga accagaagca aagcgttggt acgatcttca
    19261 ctcgttcctg acgcgttgca ggaggaagat accatcaaac tagtgtggta gtttttctag
    19321 attaagacag aatcaatcta tgttgcaatc cctgtttctt tggtaacaac agatccttat
    19381 caaaaaattg ggtcttaaac ccgcccaata ggcacgctac ggtcatacat tatttactaa
    19441 gcaactacta agcaacaatt aacccgtttg aacgacgtat taactgtacg ttgctagaag
    19501 caatttgccc taaccgtttt gctgacctta aatctgttag tttttttact tcacacggtc
    19561 gcctcttgag aaaaatcgta catcgcgcta gtcttcatgg acgtaactgc acactgtaac
    19621 attaggcgat gacaaatcaa ctctctccga aaattccctc ttgcacttgg aaacgtccta
    19681 tcggcttagg ctgggacaaa ccttataccg tccgctacgc aagtaatatc gatgatggcc
    19741 cttggcatgg tatgccttta ggtggctttg gtgcaggctg catcggtcgt tcttcacggg
    19801 gagattttaa cctgtggcac atcgacggtg gtgagcatac cttcaaaaac gttcccgctt
    19861 gtcaattcag tgtgtttgag tccaatggta catcttccca agcctacgct ttatctaccc
    19921 aagcacccga tgatggtact ctcaaggctt ggcagtggta tccagccaat aataaagcag
    19981 aggggcagag gggcagaggg gcagaggggc aggaagaaat ctttagtatc tctaacacag
    20041 ggacttatca cgcgctatac ccacgtagtt ggtttgtgta tgaaaatgta tttcaagcac
    20101 agttgacttg tgagcaattt tccccaattt gggcaggtaa ttatcaagaa actagctacc
    20161 cagtggcaat attcctctgg aatgcccaca atccaacaga tgcaccgatt actctcagca
    20221 ttatgctcac ttggcaaaat atggtgggtt ggtttacaaa tgctctcaaa tctcctcaag
    20281 tgcgggtgcg cgatgatggt agtccggttt acgaatacca accacgctgg ggcgaaagtc
    20341 aaggaaacta taaccaaata gttgaaaata cacaacactt tggctgtgtt ttaggtcggg
    20401 ttgctagtga tgaagcatta caagaaggtg atggaacatg gtgcattgcg acgctgaagc
    20461 atccccaagt agaaatattt caccacagcc gatggaatcc tgaaggaacg ggtgaggaag
    20521 tatggcaaag ttttgctgaa gatggctctt tgcccaatta tcttgatgcc actccagcag
    20581 taaataatac acagctaggg gctgcgatgg cactccgttt tactctccaa ccaggcgaaa
    20641 ctctggaaat cccctttgtc ctggcttggg atttacccat cacagaattt gcggctggag
    20701 ttaactatta ccgcagatat acggactttt ttgataaaag tggaaataat gcttgggcga
    20761 tcgcatctac tgccctacaa gaatatcaaa actggcgatc gcaaattcaa gcttggcaaa
    20821 aacctattct cgaccgggaa gatttaccca actggtttaa aatggctcta tttaatgagc
    20881 tttacgacct taccagtggt ggtactctct ggagtgcagc atcagaactt gaccccatcg
    20941 gtcagtttgc ggtgctggag tgcttagatt atcgttggta tgaaagtcta gatgtgcggt
    21001 tgtatggctc ttttgcccta ctgatgctgt ttccagaatt agaaaagtca gtaattcgag
    21061 catttgcacg ggcaattcct caaggtgatg atactccgcg aatcatcggt tattacatga
    21121 caattaaagc agaaagcccg atcgccgttc gcaaagttgc aggtgcaaca ccccacgatt
    21181 taggcgcacc gaatgaacac gtttggcaaa aaaccaacta caccagctat caagactgca
    21241 acttgtggaa agatttgggt agtgattttg tcttgcaagt ataccgtgat tttctgctca
    21301 cgggtgctga cgatgtggaa ttcttagcag attgttggaa tgcgatcgtt caaacccttg
    21361 actacctgaa aacctttgac cttgatcgcg atgggattcc tgaaaattct ggtgcgcctg
    21421 accaaacctt tgatgattgg cggttacaag gagtcagcgc ctattgtggg gggttatggt
    21481 tagcagcact agaggctgcg atcgcaatca gcgatatttt attaacttac cagacaggta
    21541 acacaacaga gttggcggtt caaaaatcca tctatgaaac ttggttaaaa caatctcgcc
    21601 cgatctacga cgaaaaactt tggaatggaa aatattaccg acttgatagt gaaagtggtt
    21661 ccgatgtggt gatggcagat caattgtgcg gacagtttta tgctcgtctg ctggacttac
    21721 ctgatattgt accgagcgat cgcgctcttt ctgccctgaa aactgtttat gatgcttgct
    21781 ttttgaagtt ctgcaatggt gagtttggtg ctgctaatgg tgttcgtcct gacggttcac
    21841 cagaaaatcc ccaagcgact catcccttag aagtttggac gggaataaac tttggactgg
    21901 cggcttttct cgtacaaacg ggaatgaagg atgaagcatt gaagttgaca caagctgtag
    21961 tgcagcaaat ttatgataat ggtctgcaat ttcgcacacc agaggcgatc accgcagcag
    22021 gtacttttcg cgctagcact tacttacggc caatggcgat ttggggaatt tacttagtta
    22081 ttaattagac atctccaaaa aagaatgtag agacgtagca ctgctacgtc tctacaaggg
    22141 ttttggataa cgcatatttc aattccaata cagttcagaa tgagcaacaa aacacttgta
    22201 aagacggcga tttatcgcgt cttgttttat cgtgtctcga aaccccaaaa tctttgccag
    22261 tagcccttca cacaagcgta ttgatttaaa ttcggtcgat gtctatttat gattttattt
    22321 tctgagtgtt tccggaagtc aaggaaaatt tcagtaatgg taagagttga aggattgaga
    22381 attcaagatt actgtttcaa agaatgcaaa tattactagc tctagctata aatattgcta
    22441 atatttcccc gactacgttc acaatcaaaa gctaggttta tgaagtacct actcctgcat
    22501 tcaacagcaa agttcattca aatagtgatg ctgcgtgttt tgtttggcaa tgattaacca
    22561 atactggggc atacgcttaa acctctacaa tttgcgtaac ttagctacag gtg
//
