LOCUS       NZ_CP040272            20933 bp    DNA     circular CON 31-AUG-2024
DEFINITION  Nostoc sp. C052 chromosome, complete genome.
ACCESSION   NZ_CP040272
VERSION     NZ_CP040272.1
KEYWORDS    RefSeq.
SOURCE      Nostoc sp. C052
  ORGANISM  Nostoc sp. C052
            Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
            Nostoc.
REFERENCE   1  (bases 1 to 7828336)
  AUTHORS   Li,F.-W.
  TITLE     Complete genomes of symbiotic cyanobacteria from bryophytes provide
            new insights into the evolution of Vanadium-type nitrogenase
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7828336)
  AUTHORS   Li,F.-W.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-MAY-2019) Boyce Thompson Institute, Boyce Thompson
            Institute, 533 Tower Rd, Ithaca, NY 14853, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.4.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 84.0x
            Sequencing Technology             :: Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013393905.1-RS_2024_08_31
            Annotation Date                   :: 08/31/2024 08:18:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,527
            CDSs (total)                      :: 8,409
            Genes (coding)                    :: 8,174
            CDSs (with protein)               :: 8,174
            Genes (RNA)                       :: 118
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 104
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 235
            CDSs (without protein)            :: 235
            Pseudo Genes (ambiguous residues) :: 0 of 235
            Pseudo Genes (frameshifted)       :: 84 of 235
            Pseudo Genes (incomplete)         :: 168 of 235
            Pseudo Genes (internal stop)      :: 38 of 235
            Pseudo Genes (multiple problems)  :: 50 of 235
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:15:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2980780
            Orig. end                         :: 3001713
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040272.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Fay-Wei Li, Boyce Thompson
            Institute, 533 Tower Rd., Ithaca, NY 14853, USA.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20933
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="10"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20933
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20933
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10933](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10933)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            940..2051
                     /locus_tag="FD723_RS11865"
                     /old_locus_tag="FD723_11855"
                     /pseudo=""
     CDS             940..2051
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1238: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015117034.1"
                     /locus_tag="FD723_RS11865"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11855"
                     /product="IS630 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPAKNHLTSQQIEKLQKALKLEENGEIRERILILLLLNDGKTQAN
                     IAEFLGCSLNKVSYWCVHGDPENLESLKDERMKGNHKKATDKYIEILLETIDKEPEELG
                     YEFGRWTAQRLATYLEQLTGIQLSGSQVRRILEKKSTSTSGQNIA"
     misc_feature    2163..2176
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.08"
                     /tool="antismash"
     gene            2163..2936
                     /locus_tag="FD723_RS11870"
                     /old_locus_tag="FD723_11860"
     CDS             2163..2936
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013884.5"
                     /locus_tag="FD723_RS11870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11860"
                     /product="acyltransferase"
                     /protein_id="WP_218651812.1"
                     /transl_table=11
                     /translation="MTLSGLIAHISMFQDFVNTTQINYVFWSIALESHLYLCFPLLVLS
                     WQRFGSIKTTLGIGLFTYITIILLEIAQVKEIPPQFLGLCFYFVLGMLGATIVFSQDRL
                     WALMRKHFPWHFVIAGLILTIILFCYLWGFDIAEERFAFLDTMTALGTLFLLVAASRPG
                     ANKVRNFLGSSLLVFIGTFSYSLYLIHAPLLQIVWQYVLHPLHLGKVFEFVLLLLVGTP
                     MILGAAYVFFFYCERPFLNTRRVSASKLTNNRIRN"
     gene            3135..4454
                     /locus_tag="FD723_RS11875"
                     /old_locus_tag="FD723_11865"
     CDS             3135..4454
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011320347.1"
                     /locus_tag="FD723_RS11875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11865"
                     /product="ABC exporter membrane fusion protein"
                     /protein_id="WP_179065521.1"
                     /transl_table=11
                     /translation="MANQLLSKPNKCWVISLSIIAGLAPIGISVYILQNYQLNFQSRSS
                     LTQTPVRASSAVTTIAGLGRLEPQGEVIHLSAAASAEGGVKVAQLLVKEGDQVQPKQVI
                     AILENRDRLLAVREQAKKQVKVAQASLAKVKAGAKVGEIIAGQATIARLQAQLRGQIAT
                     VQVTIARLQAQLQGEKKVQQAKISRLEAQLRNAQTEFERYQMLYQQGAVEASKFDSKRL
                     EVETAKEQLKEAKAAQKQTLETLQQQINETEATQKQTSETLQQQINEAKATLNQITEIR
                     PTDLLSAEAEVESAIAALKKSEADLALAYVRSPSSSQILKINARPGEIVTEQGIADLGQ
                     TNQMYVVAEIYETDITKVRIGQRATVTSFAFAEQLRGTVVQISSQIEKKSILDTDPTAD
                     LDARVVKVKIRLDPVDSKKVAGLTNLQVEAVINISPSHQE"
     gene            4489..5655
                     /gene="devC"
                     /locus_tag="FD723_RS11880"
                     /old_locus_tag="FD723_11870"
     CDS             4489..5655
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene="devC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015216453.1"
                     /locus_tag="FD723_RS11880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11870"
                     /product="ABC transporter permease DevC"
                     /protein_id="WP_179065522.1"
                     /transl_table=11
                     /translation="MFIKIPLAWLQLTRKKSRLLAAMAGIAFADILMFMQLGFQDALYE
                     SNTQLHKSLQGDLFLINPQSQTIAYMESFSRRRLYQARGFDNVESVNSFYVDFIRFKNP
                     ETRYNRTILFLGFNPNERVLKLPGIPENINKIKLPDVVLLDSASRPEFGTMAISEKLKQ
                     GQIVSTEMGGHKIKVGGLFKLGNSFAADGNLIASDLTFLRIFKFKNRNPEQIDIGLITL
                     KPGSDTQKVKANLVANLPQDVRVLTKQEFVDFEQEHWASSTPIGFIFSLGVMMGFLVGA
                     VIVYQILYTGVSDHLAEYATLKAMGYADIYFLGVVLQEALILAILGYTPGFILSVFLYD
                     FAQNATLLPIVMNVYRASGVLISTIFMCSIASAFAIVKLRSADPSDIF"
     misc_feature    5672..5689
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.83"
                     /tool="antismash"
     gene            5693..6085
                     /locus_tag="FD723_RS11885"
                     /old_locus_tag="FD723_11875"
     CDS             5693..6085
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF036613.5"
                     /locus_tag="FD723_RS11885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11875"
                     /product="DUF5360 family protein"
                     /protein_id="WP_179065523.1"
                     /transl_table=11
                     /translation="MKKLKFFFLITDIGFILYWSITLLHLIPDRYLFKDYTNPILVAWN
                     FSFLPLDLLISFTGLLSLFLYQKGKIVWIKFALTSLILTFCSGLQAIAFWTLRLDFDLN
                     WWLPNLFLLIYPMFFIPRIISNKIVE"
     gene            6311..7027
                     /locus_tag="FD723_RS11890"
                     /old_locus_tag="FD723_11880"
     CDS             6311..7027
                     /EC_number="2.6.99.2"
                     /GO_function="GO:0033856 - pyridoxine 5'-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017653234.1"
                     /locus_tag="FD723_RS11890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11880"
                     /product="pyridoxine 5'-phosphate synthase"
                     /protein_id="WP_179065524.1"
                     /transl_table=11
                     /translation="MPTLGVNIDHIATIRQARRTVEPDPVAAAVLAELGGADGITVHLR
                     EDRRHIQDRDVRILRQTVRSHLNLEMAATEEMLAIALDIKPDYVTLVPEKREEVTTEGG
                     LDIIGKIARIGEIVDKLQSASIPVSLFIDAESAQIEASVKVQAQFIELHTGQYAEAKDE
                     TNRHRELAILAKGCEQAIQAGLRVNAGHGLTYWNVYPVAALPGMEELNIGHTIISRAAL
                     VGIERAVREMKQAIKG"
     gene            7208..7927
                     /locus_tag="FD723_RS11895"
                     /old_locus_tag="FD723_11885"
     CDS             7208..7927
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015215284.1"
                     /locus_tag="FD723_RS11895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11885"
                     /product="SnoaL-like polyketide cyclase"
                     /protein_id="WP_179065525.1"
                     /sec_met_domain="PF07366 (E-value: 3.2e-06, bitscore: 25.5,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATQSNNLPLWVQDRDQVIAESTDVEWRYQTPPDYSRSKENLAK
                     ESIYNHLEGTLEAIVQNLVRTFEMEVSFKANPQQWLSIVNEQFRVSTNGGVEYTAADLS
                     AQGTYNLFMADSEHYKASEESFESSAKVFHTTFPQGFPWEVLEVFSGPPNVTFKWRHWG
                     HFNGEYKGHAPTGETVEIIGMSIAKVTDDLKVISLEHYFDNNLFLEKLTSGGKQTDAGN
                     QKSACPFSSWFKKSHKS"
     gene            7991..8320
                     /locus_tag="FD723_RS11900"
                     /old_locus_tag="FD723_11890"
     CDS             7991..8320
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016875706.1"
                     /locus_tag="FD723_RS11900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11890"
                     /product="MgPME-cyclase complex family protein"
                     /protein_id="WP_179065526.1"
                     /transl_table=11
                     /translation="MQTYHYVLASQRFLLQEEPIQEVLKERTRNYHEQEKQIDFWLVEQ
                     PAFLEAPQFRELKAKCPQPAVAIISTNPQFITWLKLRLEYVITGEFQAPSEAIPDALAS
                     LATVS"
     misc_feature    complement(8019..8030)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.84"
                     /tool="antismash"
     misc_feature    complement(8497..8510)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.38"
                     /tool="antismash"
     gene            8547..9212
                     /locus_tag="FD723_RS11905"
                     /old_locus_tag="FD723_11895"
     CDS             8547..9212
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012410128.1"
                     /locus_tag="FD723_RS11905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11895"
                     /product="hypothetical protein"
                     /protein_id="WP_179065527.1"
                     /transl_table=11
                     /translation="MHRFQTLPSVLGLAIAGLIGGTSSVFAQQAIPLCQPPNAGEYLLL
                     VVSPTANNQKQLRSALPPELKTITCKYLNETVTRVGGFNKIDDANRWARYVSNIVGLSA
                     IITTRPTTPDVQALQPQAQRQLQPPQQTVSYSPQALGEGYAVLVDYYNRPELVNSVQQA
                     VGGNVGFVSYGQRPYLLAVYTTNQSEAYNTLQKLNNGGFVASIVDSRKVILLRSTVRF"
     gene            complement(9269..9724)
                     /locus_tag="FD723_RS11910"
                     /old_locus_tag="FD723_11900"
     CDS             complement(9269..9724)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015207140.1"
                     /locus_tag="FD723_RS11910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11900"
                     /product="divergent PAP2 family protein"
                     /protein_id="WP_179065528.1"
                     /transl_table=11
                     /translation="MQDIGNILDNRVLLVALVACLIAQALKLVIEIIKNRKLNIRVLVT
                     TGGMPSAHSALVTALAAGVGQTLGWASPDFAVAMVFAIIVMYDAAGVRQAAGKQARILN
                     QMIDELFHEKPDFSQDRLKELLGHTPVQVIAGSALGITIYWLARSAY"
     gene            complement(10001..10933)
                     /gene="crtE"
                     /locus_tag="FD723_RS11915"
                     /old_locus_tag="FD723_11905"
     CDS             complement(10001..10933)
                     /EC_number="2.5.1.1"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0033386 - geranylgeranyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="crtE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017653228.1"
                     /locus_tag="FD723_RS11915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11905"
                     /product="geranylgeranyl diphosphate synthase CrtE"
                     /protein_id="WP_179065529.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1e-61, bitscore:
                     207.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVATDKVQKTPPEETTFNLVAYLKERQKLCDNALDRSIPVIYPEK
                     IYEAMRYSLLAGGKRVRPILCLATCEMMGGTIEMAMPTACAVEMIHTMSLIHDDLPAMD
                     NDDYRRGKLTNHKVYGEDVAILAGDGLLALAFEFVALQTPQSVPRELVLQVVVRLGRAL
                     GAAGLVGGQVVDLESEGKSDISLETLNFIHQHKTAALLEASVVCGGIITDASPEDVQRL
                     TRYAQNIGLAFQIIDDILDITSTQEQLGKTAGKDQKAKKVTYPSLWGLEESRSKAQELV
                     KAACVELEPFGDRAKPLQAIAHFITSRNN"
     gene            complement(11081..11968)
                     /gene="folD"
                     /locus_tag="FD723_RS11920"
                     /old_locus_tag="FD723_11910"
     CDS             complement(11081..11968)
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /gene="folD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015139950.1"
                     /locus_tag="FD723_RS11920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11910"
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD"
                     /protein_id="WP_179065530.1"
                     /transl_table=11
                     /translation="METKTAKLLDGKTLAAKIQQELSVAITELQPKIGRPPGLAVLMVG
                     DNPASAAYVRNKEKACAKVGIASFGKHFPTQTTLGELEEVIAALNHDERVDGILVQLPL
                     PNHLDAVTLLHQIDPNKDADGLHPVNLGRLVRGETGLRSCTPAGVMRLLEAYEIPLQGK
                     QAVVVGRSILVGKPMALMLLEADATVTIAHSRSHDLKTITQNADILIAAVGRPGLISAD
                     MVKPGAVVVDVGMNRVTDANGKSRLIGDVDFESTADVAGFITPVPGGVGPMTVAILLEN
                     TFASYFRATKEERK"
     gene            12233..12649
                     /locus_tag="FD723_RS11925"
                     /old_locus_tag="FD723_11915"
     CDS             12233..12649
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017317435.1"
                     /locus_tag="FD723_RS11925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11915"
                     /product="hypothetical protein"
                     /protein_id="WP_179065531.1"
                     /transl_table=11
                     /translation="MQKTRNFPLSFLYGHSIFPYRLGLTCFLVAGLSSCGNLTLPSLSK
                     TGLKFRTNVTPIGEIKPKQDNQAIVYIQGQVEKQAPLIKQWAYKISDSTGKIWVVTNQK
                     NLGEGSQVVIKGKIRYRSIPLAGKELGEVYLEEE"
     gene            12683..13117
                     /locus_tag="FD723_RS11930"
                     /old_locus_tag="FD723_11920"
     CDS             12683..13117
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012410123.1"
                     /locus_tag="FD723_RS11930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11920"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_179065532.1"
                     /transl_table=11
                     /translation="MNNQQVHVAIAILYQKNKFLMQLRDNIPGILYPGYWALFGGHIEP
                     GETPDVAVKREILEEIGYDLPPFVEFGCYPNERVVRHVFHAPLLVELNQLVLNEGWDMA
                     LFTPEDIRQGNCYSQNAGKIRPLGAMHQKIMLDFIEKNPT"
     gene            13217..14320
                     /locus_tag="FD723_RS11935"
                     /old_locus_tag="FD723_11925"
     CDS             13217..14320
                     /GO_function="GO:0015562 - efflux transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:1905887 - autoinducer AI-2 transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017653222.1"
                     /locus_tag="FD723_RS11935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11925"
                     /product="AI-2E family transporter"
                     /protein_id="WP_179065533.1"
                     /transl_table=11
                     /translation="MQSANKLPRWLTIGLAFPIAILNGWLLIQVIQYFQPLVSIIAAAI
                     LLAFVLNYPIQFLQEQGVKRNLAIGGVLLLTLVVLVALGITLVPLIIQQLVELANILPS
                     WIDSGTQQLQAFQDWALSQQQLPINLSGLFTQVLERLSNQLQSFTGRILGFAVDTIGIV
                     LNVLLAVVLTIYLILNGERLWDGIFQWFPPNIGFKVRELLREDFHNYFIGQATLGAVLG
                     VTITLAFLALQVPLALLFGIGIGLFSLFPFGTGVGIAIVSLLVALQNFWLGVEVLGVAV
                     AIDQVNSNIIAPRILSNLTGLNPVWVVISLLLGAKLGGVLGLLVAIPIASFIKDITDSW
                     RAGEFNKIDDIESEPIAITTERAGTYS"
     misc_feature    complement(13226..13239)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.07"
                     /tool="antismash"
     gene            complement(14725..15459)
                     /locus_tag="FD723_RS11940"
                     /old_locus_tag="FD723_11930"
     CDS             complement(14725..15459)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012409023.1"
                     /locus_tag="FD723_RS11940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11930"
                     /product="HAD family hydrolase"
                     /protein_id="WP_179065534.1"
                     /sec_met_domain="HAD_2 (E-value: 1.3e-19, bitscore: 69.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATIKCRNIIFDNIQAILFDKNGTLEDSETYLRSLAQKAARLIDA
                     QIPGTGEPLLMAFGINGNLLDPAGLVSVASRRETEVAAAAYIAETGRGWFECLKIARQA
                     LDEAEKYIGQTPSPLFVGSLDLLKYLQEGGLKLGILSAATTEEVRNFVANHQLNDYIQL
                     EMGVDEGPSKPDPVLFLQACQALGVEPNATLMVGDSVGDMQMARNAKAAGCIGITWVGK
                     SDNVRGADVVINQLDEIQILED"
     gene            complement(15591..16688)
                     /locus_tag="FD723_RS11945"
                     /old_locus_tag="FD723_11935"
     CDS             complement(15591..16688)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012409024.1"
                     /locus_tag="FD723_RS11945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11935"
                     /product="30S ribosomal protein S1"
                     /protein_id="WP_179065535.1"
                     /transl_table=11
                     /translation="MVNQNLTATEIGFTHEDFAALLDKYDYHFSPGDVVPGTVFSIEPR
                     GALIDIGAKTAAYIPIQEMSINRVDSPEEVLQSNETREFFILTDENEDGQLTLSIRRIE
                     YMRAWERVRQLQAEDATVRSGVFATNRGGALVRIEGLRGFIPGSHISTRKPKEELVGED
                     LPLKFLEVDEERNRLVLSHRRALVERKMNRLEVGEVVIGTVRGIKPYGAFIDIGGVSGL
                     LHISEISHEHIDTPHSVFNVNDEVKVMIIDLDAERGRISLSTKQLEPEPGDMIKNRDLV
                     YDKAEEMAAKYREQLLAKQQGATAAPAAPAETVADEDIPPAAELEEEIPPAAELEQENS
                     VVAEIEKEIPAATETEEEIPAAIEE"
     misc_feature    complement(16938..16954)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 25.34"
                     /tool="antismash"
     gene            complement(17074..19149)
                     /locus_tag="FD723_RS11950"
                     /old_locus_tag="FD723_11940"
     CDS             complement(17074..19149)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR01846.1"
                     /locus_tag="FD723_RS11950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11940"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_372743814.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-05, bitscore:
                     23.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAQQLENSVQLEWVQRQLRGQRPKQVVEAAEKLGLVLRRLQVSW
                     GELRQLSFPALLLWSSDSPQSPSWVVAYGVKGDRLIIANPLNPERTCESLPQSIVEASW
                     DGQLWQVELVSRQEKFNLNWFTPAVWKYKGLLVEVLLASFTLQLLGLTTPLITQVVIDK
                     VMVQGSLPTLDVMAIALLCVAVFESILGILRLFIFTHTARRLDLSLSAQLFRHLMRLPL
                     AYFESRRVGDTVARVQELEQIRQFLTGTALTVILDSIFTVVYLVLMFYYNVPLTFVALA
                     VLPLFATLTIVSTPILRNWLNETFNRSADSQSFLVETITGIHSVKAHAAEPVARDRWEG
                     LFARFIRTGFKASTTSNISSNIGDFLTNLSTMLILWFGAKLVIEQKLTIGQLVAFQMLS
                     GRVTGPLLRLVQLWQNLQQVLLSVDRIGDILNVSPEAELGTGLVLPPLKGQITFEQVFF
                     RYRPNFEAILRGISFNAEPGQFVGIVGRSGSGKSTLSKLLQRLYQIESGRILIDGFDIK
                     SADLASLRQQVSVVLQEDFLFNGSILENITLGSPDITAEQVVEAARLAVAHDFISQLPY
                     GYETNVGERGTALSGGQRQRIALARLFLSQAPILVLDEATSALDSETEQQVLQNLQKIS
                     ANRTVFLIAHRFAPLKRADLILVLEQGVIAERGTHSQLLQQKGLYWSLYQRQQANI"
     gene            complement(19439..19555)
                     /locus_tag="FD723_RS44120"
     CDS             complement(19439..19555)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019144.5"
                     /locus_tag="FD723_RS44120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_372743815.1"
                     /transl_table=11
                     /translation="MLNCGWKSPLARRRHWQTNSCPRCGGLVWRLTKAVCGF"
     misc_feature    19613..19627
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.65"
                     /tool="antismash"
     gene            complement(19728..20510)
                     /locus_tag="FD723_RS11955"
                     /old_locus_tag="FD723_11945"
     CDS             complement(19728..20510)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015139291.1"
                     /locus_tag="FD723_RS11955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FD723_11945"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_179065537.1"
                     /transl_table=11
                     /translation="MESSSFLTINDQIISVEEAVKYLQASGKLGQFIGDILRQYVIEEE
                     IRTRNDIEIGTAITEQSIIDFRLKNQLTDPESFQEWLKINNTDYATFHTSVTFGYKLEK
                     LKAVVTQTKIQEYFIERKIFLDRVVLSRIVVNNRELADELHTQIEEGGSFEQLAKEYSL
                     SDDRIVNGMMGIVSRGSMPDILRAAIDVASPGQLVGPIEIVGKDSPQGEGPFGLFRVEQ
                     FLPASLEDTQLQQVLQNELFEKWLAEKIQKLTVKLQVS"
ORIGIN
        1 taacgaacaa caatttcaaa gagaagaaaa gaaaatccgt attaacgcca ttggaggtgg
       61 acggaaaccg aaattaacaa ttgcagaaga aatatgtctg agcctgttct acttaagaca
      121 aatgcctaca tttgaaattt taggaatgaa cttcgatatc tcgaaaaccg aagcgaatga
      181 tactttccat tattggctaa aaatcttgcg agaagttttg cctgctagtt tactagaaca
      241 ggtagaaaat caagaaagtg attatataac ggtgcaagag ctattaaggg aatttgaatt
      301 aattgttgat agctacgaac agcctagaga aagaccatca gacaatcaag agcaacaaga
      361 atacttttca ggcaagaaga agcaacatac tcttaaaagc caagttgttt cgctgccaga
      421 tgctaaagat attgttgata tagtagtagg agcaaagggt caaaccagtg atatttcatt
      481 gtttcgtaat caacaacaaa gattttctcc tgaacaatca tttaaaggtg ataaaggtta
      541 tcaaggtggt aaaaacatta gtacacctca caaaaaacca cctaaaggcg aattaactac
      601 cgaacaaaaa gccgaaaata aagtcttttc tagtaatcgg attttcattg aacacataat
      661 tcgacttatc aagattttcc gcattgcctc ttgacgattt cgacttcatt atacagtgta
      721 tgagcagata atttttactg tttgtggctt agttagatta agaattggta gtttagtttt
      781 accaacttaa tcaaaagtga taattgtaca attatacaaa ataaagggag catatatttt
      841 ttggtctaaa ctatctctaa ctatctctaa ccctgattaa gctgttcagc atttaaattg
      901 ggtataataa aaaactgaat tcagtcaaaa aatggaataa tgccagcaaa aaatcattta
      961 acttctcagc agatagagaa actacaaaaa gctttaaaac tggaagaaaa tggagaaata
     1021 agagaaagaa tactaattct cttgttgctt aatgacggga aaacacaagc taacatagca
     1081 gaatttttgg gttgttcttt aaataaagta tcatattggt gtgtacatgg agacccagag
     1141 aatctagaaa gcctaaaaga tgagaggatg aagggaaacc ataaaaaagc cacagataag
     1201 tatatagaaa tattactaga aactatagat aaagaaccag aagaattagg atacgagttt
     1261 ggcagatgga cagcgcagag attagcaaca tatttagagc aactcacagg catacaatta
     1321 agtggttctc aagtaaggag gatattagag aaaaaaagta cgtctacctc tggacaaaat
     1381 atagcttaga gtccaagagg aatctagaaa aaagaaaagc atttaaacag aaaatagcag
     1441 agtatttaag aatagagaaa gagcatccag aacgattaca ggtatggttt tgggatgaga
     1501 gtggctttag tttaagggtg ataagaagaa aatcatggtg taaaaaaggt cactctaaaa
     1561 acgtgagagg agacagaaga aaagggagaa ttaatgtgat gggaggatta aggtattcag
     1621 ataagaaaag atttgtagaa tttattgata aagggaatgc agacaatttt tacaaagtcc
     1681 taaaaatctt ttatgaagaa atagttttcg attgggtaga agctggtaat caagctaaag
     1741 attttgcgga gaagggagca aaaatagtta ttattcttga taatgcaagt tttcacaaaa
     1801 agcaagagta tattaataaa attgaaacag aaatgccgaa tattcattta gagtttctcc
     1861 cggaatatag cccagattat aacttaattg aattggtctg gcactcgaca aaagaatata
     1921 ttgctaatcg gctatttcaa tcaattgaag acctagaata tttattacat caacttttaa
     1981 atgaaggaga gttaattatt aaatggggac gaaaactcaa aaataaaggc gatgctgtta
     2041 tcacaattta aatgcacaac agcttactac gtttttatga agatatcaaa gctggctttc
     2101 aaagctttgt acagactcgc ttgtaaattt tcggacaggt ctagtgggat ataagcgtac
     2161 cagtgacgct gagtggattg attgcacata tctcaatgtt ccaagatttt gttaacacga
     2221 cccaaattaa ctatgttttc tggtctatcg cccttgaatc acacctatat ctttgctttc
     2281 cccttctcgt actcagctgg cagcgctttg gcagcattaa gaccacactt ggaatcggct
     2341 tatttactta tattactatt attctgctgg aaatcgcgca ggtaaaagaa atacccccac
     2401 aatttttagg tttgtgtttc tattttgtat tgggaatgct tggtgcaacc atcgtctttt
     2461 cccaagatcg gctttgggca ttgatgcgta agcattttcc ctggcacttc gttatagctg
     2521 gtttaattct gacaattatc ttgttctgct atctctgggg attcgatata gcagaagagc
     2581 gttttgcctt tttagatact atgactgcat taggtacgtt gtttttgctt gtagctgcct
     2641 cacgtcctgg agcaaacaaa gttcgtaatt ttctaggttc aagtctactt gtctttattg
     2701 gtacattctc gtacagcttg tatctcattc atgcacctct actacaaatt gtctggcagt
     2761 atgttctgca tccattacat ctcggaaaag tctttgagtt tgttttactt ctgcttgtag
     2821 gcacaccgat gattcttggt gcagcatacg tcttcttttt ttattgcgag cggccattct
     2881 taaatacacg ccgagtttca gcatcaaaat taacaaacaa cagaataagg aactgagaaa
     2941 ttttttaaat agttttaatg ataaccttat gtgatccaaa aatactcatt tcttttggga
     3001 aaagtatcaa aagtagtcgt aacagcaagg taatattcat atacgccaaa atattaaaca
     3061 atctaattct ctgaaattac cgctccctga atcctgaaaa accaatataa ggtagacaaa
     3121 tacagaaaat aaaaatggca aaccagttat tatcaaaacc taataaatgc tgggttatta
     3181 gtttatcaat tattgcaggt ttagccccaa ttggcatctc tgtgtacatt ctgcaaaatt
     3241 accaactcaa ttttcagagc cgtagctcct taacacagac acctgtgagg gcttcgtcgg
     3301 ctgtcactac tattgctggt ttgggacgtt tggaacctca aggagaagtc attcatttgt
     3361 ccgcagcggc ttctgctgaa ggtggtgtta aagtagccca actgcttgtt aaagaaggcg
     3421 atcaagttca gcctaagcag gttattgcca ttttagaaaa ccgcgatcgc ctgctagctg
     3481 ttagggaaca ggcaaaaaaa caagttaaag tcgcccaagc tagtttagcc aaggtaaaag
     3541 ctggtgcgaa agtaggagaa atcatcgctg gacaagctac aattgctcgc ttacaagctc
     3601 agttgcgtgg gcaaattgca actgtgcaag ttacaattgc tcgcctacaa gctcagttgc
     3661 aaggagaaaa gaaagttcaa caagctaaga tttctcgtct agaagctcag ttgcgtaatg
     3721 ctcagacaga gtttgaacgc taccagatgc tataccaaca aggtgcggtt gaagcctcaa
     3781 aatttgacag caagcgcctg gaggtagaaa ctgctaaaga acagttgaag gaggcaaaag
     3841 ctgctcaaaa gcagacttta gaaactttgc aacaacagat taacgagact gaagccactc
     3901 agaagcagac ctcggaaact ttgcaacaac agattaacga agcaaaagcg accttgaacc
     3961 agattactga aatacgtcca actgatttgc tgtctgctga agctgaagtt gaaagtgcga
     4021 tcgcagcctt aaaaaaatct gaagcagact tggctttagc ttatgtgcga tcgccctctt
     4081 ctagtcaaat tttgaaaatt aatgctcgac ctggagaaat tgtcacagag cagggaattg
     4141 ccgatcttgg tcaaacaaat caaatgtatg tggtagcaga aatctatgaa accgatatta
     4201 ctaaagtacg aattgggcaa cgcgccactg ttacaagttt tgcatttgcc gagcaattac
     4261 ggggaactgt ggttcagatt agctcgcaaa ttgagaaaaa aagtattctt gataccgacc
     4321 caaccgcaga tttagatgca agagtagtca aagtcaaaat ccgcctcgat ccagtagata
     4381 gcaaaaaagt ggcaggttta acgaatttac aagtagaggc ggtgattaat atttcacctt
     4441 ctcatcaaga ataactagac attcaacaaa tctcaataaa attctactat gtttattaaa
     4501 attcctctag cttggttaca actaactcgt aaaaaaagtc gccttctggc ggcaatggca
     4561 ggcattgcat ttgcagatat tctcatgttt atgcaattgg gtttccagga tgctctgtat
     4621 gaaagtaata ctcagctgca taagagccta caaggcgatt tatttttaat taatccccag
     4681 tctcaaacaa ttgcctatat ggaaagcttt tctcgacgcc gattgtacca agcgcgaggc
     4741 tttgataatg ttgagtctgt taattctttt tatgtcgatt ttattagatt taaaaatcca
     4801 gaaactcgtt acaatcgaac aatcttattt ttaggtttta atccaaacga acgagtttta
     4861 aaattacctg gtatcccaga aaatataaat aaaattaagc tacctgatgt ggttttactt
     4921 gacagtgcgt cacgtcctga atttggcaca atggcaattt ctgaaaaact taaacaaggt
     4981 caaattgttt ctactgagat gggtggtcat aaaataaaag tgggaggatt attcaaatta
     5041 ggtaactctt ttgctgctga tggaaattta attgccagtg acttgacatt cttgcgaata
     5101 ttcaaattta aaaaccgcaa tcccgaacaa atagatatag gtttaattac tctaaaaccg
     5161 gggtctgata ctcaaaaagt caaagcaaat ttagtggcta acttacccca ggacgttaga
     5221 gtacttacca agcaagaatt cgtggacttt gagcaagaac attgggctag cagtacgccc
     5281 attggtttta tctttagcct gggtgtcatg atgggatttc tagtcggtgc ggttattgta
     5341 tatcaaatac tttatactgg tgtttccgat cacctagcag agtatgcaac gctgaaggca
     5401 atgggatatg cagatattta ctttctaggt gtcgttttac aagaggcctt gattttagct
     5461 attttaggct atacacctgg ttttatttta tctgttttct tgtatgattt tgcacaaaat
     5521 gcaacattat tacctattgt aatgaatgtt tatcgggctt ctggagtact aatatcgaca
     5581 atttttatgt gttctattgc tagtgcattt gcaatagtta aattacgttc tgccgatcca
     5641 tctgatattt tctaattttc ttgtcattca ctagttaatc caatgttaaa ctatgaaaaa
     5701 gctaaaattt ttttttctga ttactgatat tggctttatt ttatattgga gcataacttt
     5761 actgcattta attcctgata gatatttatt taaggattat acaaatccta tattagttgc
     5821 ttggaatttt tcctttttac ctttagattt gctaatatct tttacagggt tattaagctt
     5881 atttctttat caaaaaggta aaatagtttg gataaaattt gcgttaacat cattaatact
     5941 gacgttttgc tcaggtctgc aagcaattgc cttttggacg ttaagactgg attttgactt
     6001 gaactggtgg ctccctaatt tatttttact tatatatcca atgtttttta ttcctcggat
     6061 tatctcaaat aaaatcgtgg aatgaaaaag ggctatgcat tagtcacatc ttttataaca
     6121 agcatttaaa gtcttctgac ttcagatttt ttagctgttc ttagaacata gataatacta
     6181 cccaactcta atctacttgt cccacgcatt taggactttt gcaaaaggtc ttttgagaaa
     6241 ctcaagcaaa actcccacta tttccggtaa aatcaagttc tgaggactgt ggatttggga
     6301 gaaacctggg gtgcctacac ttggcgttaa cattgatcac atcgccacca tccggcaagc
     6361 acggcggacg gtagaaccag accccgtagc agcggcggtg ctggcagaat taggcggcgc
     6421 agatgggatt acagtacatc tgcgcgaaga tcggcggcat atccaagaca gagatgtgcg
     6481 gatattgcgg caaacagtgc gatcgcatct gaatttagaa atggccgcta cagaagaaat
     6541 gcttgcgatc gctctcgata tcaaaccaga ttacgtgact ttagtccccg aaaaacgcga
     6601 agaagtcaca acagaaggcg gattagatat catcgggaaa attgctagaa taggtgaaat
     6661 cgtcgataaa ttgcaaagcg ctagcattcc agttagttta tttatcgatg ccgagtcagc
     6721 acaaattgaa gcatctgtca aggtacaagc tcagtttatt gaattgcaca ccggacaata
     6781 tgctgaggct aaagatgaaa caaatcgcca ccgagaatta gccatattag ctaaaggttg
     6841 tgaacaagcg attcaagctg gattgcgagt caacgctgga cacggactca cctattggaa
     6901 cgtctatcct gtggctgcgc ttccaggcat ggaagaactg aatattggtc ataccatcat
     6961 cagtcgcgca gcattggtag gtatagaaag ggcagtccgc gagatgaagc aagctataaa
     7021 agggtaaagg ggaaagggta aaggggaaag atatagaacc agcagtccgc gagatgaaac
     7081 aagctataag ggggaatagg cattgattat taaatattct cccctgcctc ccctgccccc
     7141 aatcccccac agagggttgt cactgcgaaa tctagaaatt gggatcaaat cttcagcaaa
     7201 aacttctatg agcgcaacac aatctaacaa cctgccactt tgggtacagg atcgagatca
     7261 ggtgatagca gaaagcactg atgtcgagtg gcgctatcag acaccgcctg attattcccg
     7321 ttcaaaggag aatctcgcga aagaaagtat ctacaatcac cttgaaggta cactagaagc
     7381 gatcgtgcaa aacttagtcc gaaccttcga gatggaggta tccttcaaag ctaaccccca
     7441 acagtggtta tctattgtga atgaacagtt tcgcgtgagt accaatggcg gagtagagta
     7501 taccgcagca gatttatcag cccaaggtac ttacaattta tttatggcgg attcagagca
     7561 ttataaagct tcagaagaaa gctttgaatc atccgcaaaa gtcttccaca caacatttcc
     7621 tcaaggattt ccttgggaag tactggaagt tttctcaggg ccaccaaatg tcacattcaa
     7681 atggcggcat tggggacatt ttaacggaga atacaaaggt catgcaccta ctggagagac
     7741 agtagaaatt atcggtatga gcattgcaaa agttaccgat gacttgaagg ttatttcctt
     7801 agaacattac tttgacaata atctgttctt ggaaaagcta acatctggtg gcaaacagac
     7861 agatgctgga aatcagaaaa gtgcttgtcc gttcagttct tggttcaaga aatcccacaa
     7921 aagttagttt gtaagggtac agagtcactg tgcccttaaa ttattcacat agtaactaca
     7981 aaggatgaaa atgcaaacat atcattacgt tttggctagt caacgttttc ttctccaaga
     8041 agaaccgata caggaagttc tcaaagagcg tacccgtaac taccacgaac aagaaaaaca
     8101 aatagatttt tggttagttg agcaaccagc tttcttggaa gcaccacaat ttagagagtt
     8161 aaaggcaaag tgtcctcaac cagcagtagc aattatttct actaatcccc aatttattac
     8221 ttggttaaaa ctgcgtttag agtacgtcat cactggagaa ttccaggctc cttctgaggc
     8281 aataccagat gctttggcat cgttggctac cgtatcttag cgattgggca tggggcatag
     8341 agaagagaca aggtaggcaa gaaagagggg gagataaggg agagacttgt ccccttgtcc
     8401 ccactcctca ttccctaatt ttatttttga gtaataaaat atattttttt tgatactctt
     8461 tttataccta tactgaacta actaagtttt gatctttttt cttataaaat cttctaagat
     8521 accttgattt acataatcta acttttgtgc atagatttca gactttacca agtgttttag
     8581 gattagcaat tgcagggttg attggtggca cgagttctgt ctttgcccag caagccattc
     8641 ccctttgtca accaccaaat gcaggcgagt atcttttatt agtagtcagt cccacagcga
     8701 ataatcaaaa gcagttacgt agtgccttac cacctgaact taaaactatc acctgcaagt
     8761 atctcaacga aactgtgacg cgagtaggtg gctttaacaa aatcgatgat gccaatcgtt
     8821 gggcaagata tgtcagtaat attgttggct tgtctgccat aattaccact cgaccaacaa
     8881 caccagatgt gcaggcgtta caaccacagg cacagcgaca gctacagcca cctcagcaga
     8941 cagttagcta tagtcctcaa gctttaggag agggttatgc agtgctggta gattattaca
     9001 accgcccaga actcgtaaat agtgtgcagc aagcagttgg aggtaacgtc ggctttgttt
     9061 cttatggaca acgcccttat ttgttggcag tttacactac taaccaaagt gaagcttaca
     9121 acacattgca gaagcttaac aatggcggtt ttgttgccag catcgtagat agtcgtaagg
     9181 tgattctgct gcgctcaact gtgcggtttt agtcattagt cattagtctt tagtcattgg
     9241 ttaataactg tagactgtag actattgact aataagcaga cctcgctaac caatagatag
     9301 ttatacccaa agccgatcca gcgattacct gaactggtgt atgtcctagt aattctttca
     9361 gacggtcttg gctaaagtct ggtttttcat gaaataattc atcaatcatt tgattgagaa
     9421 tacgagcttg tttgccagct gcttggcgaa ctccggctgc atcatacatg acgataatgg
     9481 caaaaaccat cgcaacagca aaatcaggag atgcccaacc cagtgtttgc ccgacaccag
     9541 cagctagagc cgtaactaga gccgaatggg cactaggcat acctccggtt gttaccaaaa
     9601 cacgtatatt cagtttgcga tttttgatga tttcgattac gagctttaat gcttgagcaa
     9661 ttaaacaagc taccagagca accagcagca cgcggttgtc taaaatgttg cctatgtcct
     9721 gcatggtatt ttggttaggt tagtaaatat tagcagcagt tgttggttga ggaaacattt
     9781 agattcaacc caaaatccca aattaatcta gtacatcatg gtggaaagag aacaactctt
     9841 caaaatcacc taaaagctta atggatcagc tttttgaatt ttgaatgagt aaattttgaa
     9901 ttccgttggg cggtgtagta gagcatagcg ttacaaaacc acccattccc aatcaagaaa
     9961 acgcttgcag tataagaatt acgaattacc caaaacatta ctagttattg cggctggtaa
    10021 taaaatgagc gatcgcttgg agtggtttgg ctctgtctcc aaacggttcc aattccacac
    10081 aagctgcttt aactagctct tgggcttttg agcgcgattc ctcaagtccc caaaggctgg
    10141 gataggtaac tttcttagct ttttggtctt taccagctgt tttacctaat tgctcttggg
    10201 tagaagtgat atccagaata tcatcgatga tttggaatgc tagcccaata ttttgagcat
    10261 aacgggtcag tcgttgcaca tcttcaggtg atgcatcagt tatgatccca ccacaaacta
    10321 cagaagcttc taaaagggct gctgttttgt gttgatgaat aaaatttagt gtttctagag
    10381 aaatatcaga tttcccttcc gactctaaat cgacaacttg accgccgacc aaaccagctg
    10441 ctcccagcgc ccgaccaaga cggacaacta cttgtaagac tagctctctg ggaacacttt
    10501 ggggggtttg aagggcaaca aattcaaaag cgagagccaa caagccatcc ccagccaaaa
    10561 tcgcgacatc ttcgccatag actttatgat tcgtcagctt cccacgacgg taatcgtcat
    10621 tatccatcgc tgggaggtcg tcatgaatca acgacattgt atggatcatc tctacagcac
    10681 aggccgtcgg catagccatc tctatggttc cacccatcat ttcacaggta gcaaggcaaa
    10741 gaatgggacg tacacgctta cctccagcta ataacgaata gcgcatcgcc tcataaatct
    10801 tttctggata aatgactggg atagaccgat ctaaagcatt atcacaaagc ttttgccgct
    10861 ctttgagata ggctactaag ttaaatgtgg tttcctctgg tggtgtcttt tgaactttat
    10921 cagttgctac catgctttaa ttcctgacat tttgggattt ttgtcttata cgtcacaatt
    10981 ttaaggtgct gtggggctga aaaaaatgaa gagttaggag ttaggagtta ggagttagga
    11041 gttaataact cttaactttt aattcatcac ttttaactca tcactttctt tcttcttttg
    11101 tcgctctgaa gtagctggca aatgtatttt ccaacagtat ggcaacagtc atcgggccaa
    11161 caccaccagg aacaggagtg ataaatcctg caacatcagc ggttgattca aaatcaacat
    11221 cgccaatgag gcgacttttg ccattagcat cggtgacgcg attcatcccc acatctacca
    11281 caactgcgcc cggtttcacc atatcggcag agatcagtcc gggacgacct actgctgcaa
    11341 ttagaatatc agcattttgg gtgatggttt tgagatcgtg cgatcgcgag tgagcgatcg
    11401 taactgtggc atcagcttct aatagcatca gcgccatcgg tttacccacc aaaatactcc
    11461 gtcccaccac tactgcctgt tttccctgca aaggaatctc ataagcttct aaaagccgca
    11521 ttacaccagc cggagtacag ctacgtaaac ccgtttctcc ccgtactagt cgccccaaat
    11581 taactgggtg cagtccatca gcatctttat tgggatcaat ttgatgcagt agagtcacag
    11641 catctaagtg gttaggtaaa ggcaactgta caagaatgcc atccacccgt tcatcgtggt
    11701 tgagtgcagc aatgacctct tctaactccc caagggtagt ttgggtagga aaatgcttac
    11761 caaaagaagc gatcccaact ttagcgcagg ctttttcttt attacgtaca taagcggctg
    11821 acgctgggtt gtcaccaacc atcaacactg ctaaaccagg agggcgccca atttttggtt
    11881 gtaattctgt aatggcgaca gaaagttctt gctgaatttt cgccgctaaa gttttaccat
    11941 caaggagttt ggcagttttt gtttccatga aaattcccag ctatattcgc ctgttgtcca
    12001 aagtccaaag taaaaatatt gattattaca tcttgtattg tgtcgctgtt tgatgtcgta
    12061 gcgtttctct cacagtaaat tcataatatt tattttctca gattaacggc atcatctgaa
    12121 gaataaagaa ttaggagtgg ggagcaaggg agaagatttt ttcccctccg ccccctgcac
    12181 cccgcccctc tgcctctttc caatgcccaa aataaataaa tcggtggctt tcatgcaaaa
    12241 aacgagaaat tttccccttt cgttcttgta cgggcacagt atttttcctt accgtttggg
    12301 attgacttgt ttcctcgtag cgggactttc tagttgtggt aacttgacat tacctagctt
    12361 aagtaagact ggcttaaaat ttaggacaaa tgtgactcca attggagaaa ttaaaccaaa
    12421 acaggacaat caggctatag tttacatcca aggtcaggta gaaaagcaag ctcctctgat
    12481 caaacagtgg gcttataaaa ttagtgactc aactggcaaa atttgggttg tcaccaatca
    12541 aaagaatctg ggtgagggtt cacaagtggt gattaagggt aaaattcgct accgaagtat
    12601 tcccttagct ggcaaagaat tgggagaagt ttatttagaa gaagagtaat cagcaattaa
    12661 attaaaaata aatatatgaa ctatgaacaa tcaacaggta cacgtagcga tcgcaattct
    12721 ctatcaaaaa aacaagtttc tcatgcagct gcgcgacaat atccccggta ttctctaccc
    12781 tggttactgg gcgctgtttg gcggacacat cgaacctggt gaaacgccgg atgtagcagt
    12841 aaaacgagaa atattagaag aaatcggcta tgatttacca ccctttgttg aatttggctg
    12901 ttatcccaac gaaagagttg tccgtcatgt ctttcatgca ccgctgttgg tggaattaaa
    12961 tcaactggtt cttaacgagg gttgggatat ggcgttattt accccagaag atatccgtca
    13021 aggtaactgt tattcacaaa atgctggcaa aatccgacct ttaggggcaa tgcatcagaa
    13081 aattatgttg gattttattg agaaaaatcc aacataattt ggggattggg gattgggcat
    13141 tgattattaa ttcttcccct gctctccact ccctagaagc cacaataaag ttagaactct
    13201 tatcgggtca tcactaatgc aatcagcaaa caaactgccg cgatggttaa ctatcggatt
    13261 ggcatttcct attgccattc tcaacggctg gctattgatc caggttatac agtattttca
    13321 acccttggtt agcattattg ccgccgccat cctactggct tttgtcttga attatccaat
    13381 ccagtttctt caggaacaag gggtgaaacg caacttagcg atcgggggag tgttgctttt
    13441 gactctggtg gttttagtag ctttaggcat caccttggtt cccctaatta ttcaacagct
    13501 tgttgaactg gctaatattt tacccagttg gattgattct ggtactcagc agctacaagc
    13561 ttttcaggat tgggccttaa gtcaacagca acttccgatt aatttaagtg gtttatttac
    13621 ccaagttctg gaacgattat ctaaccaact tcagtctttc actggtagaa ttcttggttt
    13681 tgccgtcgat accatcggta ttgtcctcaa tgtactgttg gcggtagtgc tgactatcta
    13741 cctaatattg aacggtgaac gtctttggga cggaattttt cagtggtttc cccctaacat
    13801 tgggttcaaa gtgcgggaat tactgcgaga agatttccac aattacttca tcggtcaagc
    13861 aacattggga gctgtattag gggtgacaat tacgctggcg tttttagcgc tgcaagttcc
    13921 cttggctcta ctttttggca tcggtattgg cttgttttca ctcttcccct ttggtacagg
    13981 ggtaggtatc gctatagtaa gtttattggt agcgctgcaa aatttttggt taggggtgga
    14041 agtcttaggt gtcgctgttg cgatcgacca agttaactct aatattattg cacctcgaat
    14101 tctcagcaat ttgaccgggt taaatcctgt atgggttgta atttctttat tactaggagc
    14161 aaagttggga ggagttttgg gtttgttagt tgcgatcccc attgccagtt ttatcaagga
    14221 tataacagat agctggcggg ctggagaatt taataaaata gatgatattg agtcagaacc
    14281 tattgccata acaactgaga gagcaggaac ttacagctaa agctcaatta ttgatattaa
    14341 ctgaaaaact ggtgagcttg tccataaatg aactgcaaaa ccctgattta tgatgccaac
    14401 aaataagcag ctattacttt atgtatcaat aatttttcag aaatcaaaat aagggtaaaa
    14461 aaatgagcga tcgctattta tatataatgc aaaatttgat taaatattaa tcaatgctga
    14521 acccgtacaa aaacaagata gtgtagggga gccagtgcgt tgttccgatt tccataattg
    14581 aaataggtgg ctggatttct gacgtgctgt gcttcacgta attaaaaaca gccatatcaa
    14641 ttaatagaaa aattaaatat gcgtcacccg aaaaccttgt agagacgtag caatgctacg
    14701 tctctacgtc ttttctggag atgtttaatc ttctaaaatc tggatttcat caagttgatt
    14761 aatcactaca tctgcacctc ggacattatc tgacttacct acccaagtga taccaataca
    14821 acctgcggct ttagcgttac gcgccatttg catatcacca actgaatcac ccaccatcaa
    14881 tgtagcgttc ggttcaactc ctaaggcttg acaagcttgc aaaaatagta ctggatctgg
    14941 tttactcggc ccttcatcta cgcccatttc caactggata taatcgttta actggtgatt
    15001 ggctacaaaa ttacgtactt cttcagttgt cgcagctgag aggatgccaa gtttcaaacc
    15061 cccttcttgt agatatttca acaagtctaa gctacccaca aataatggtg aaggagtttg
    15121 tccaatgtac ttttccgctt catccaaagc ttgacgggct atttttaagc actcaaacca
    15181 tcctctgcca gtttcggcaa tatatgccgc agccgcaact tctgtttcgc ggcggcttgc
    15241 tactgatact aaacctgcgg gatctagaag attgccattg atgccaaatg ccattaacag
    15301 gggttcccca gttccaggga tttgagcatc tattaacctt gctgcctttt gtgctagcga
    15361 tcgcaaatac gtttctgaat cttctagagt accgttttta tcaaacaaaa ttgcctggat
    15421 attatcaaaa atgatatttc tacatttaat ggttgccata atatttaact tctaactact
    15481 gccaattctt tatttttacc gattttccat ataaaaaaag aggggaaaac cctctttata
    15541 aaatgatttg atactcttac ttaaaaataa gtaaaactat aaaaaatcta ttactcttca
    15601 atagctgctg gaatttcttc ttcagtttcc gtcgctgctg gaatttcctt ttcaatttcc
    15661 gcaactactg aattttcttg ttcaagttct gctgctggtg gaatctcttc ttcaagttcc
    15721 gctgctggtg gaatatcttc gtctgctaca gtttccgcag gtgcggcagg tgcagcagta
    15781 gcaccttgct gcttggctaa tagctgttcg cgatacttag cagccatttc ttctgcctta
    15841 tcgtagacca aatcccggtt cttaatcatg tcgccgggtt cgggttctag ttgcttggta
    15901 gatagggaaa ttcgacccct ttctgcatcc aagtcaatga tcataacttt cacttcatca
    15961 ttgacattga acacgctatg aggtgtatca atatgttcgt gagaaatctc agaaatatgt
    16021 agtagaccac tgacgccgcc aatgtcgatg aaagcaccgt atggcttaat accacgaaca
    16081 gtaccaatta ctacttcgcc gacttctagg cggttcatct tacgctcaac caacgcccga
    16141 cggtgagata gaactaggcg attacgttct tcatccacct ctaggaattt caacggcaga
    16201 tcctcgccga ccaattcttc tttaggtttg cgggtactaa tgtgggaacc tgggataaag
    16261 ccacgtaatc cctcaatccg taccaatgct ccgccacgat tggttgcaaa tacgccagaa
    16321 cgtacagtag catcttctgc ttgcaactgt cgcacgcgct cccaagcccg catatactca
    16381 atacggcgaa tggaaagggt taattgccca tcttcgtttt catcggtaag gatgaaaaat
    16441 tcccgcgttt cgtttgactg taatacttct tccgggctat ccacccggtt aatagacatt
    16501 tcttgtatag gtatatatgc tgcggtttta gcaccaatgt caatcagagc gccgcgcggc
    16561 tctatactga aaactgttcc tgggacaaca tcgccagggc taaaatgata atcgtatttg
    16621 tcaagtagag cagcgaaatc ttcgtgagtg aatccaattt ctgtagcggt taaattctga
    16681 ttgaccatgc tgatttgttc ctggttctag tctccgtaaa ggttgtgcga caagcgcgat
    16741 gtgctatgta agcactttta tggcagccta cacaaaacat ccattttcat cctagcgcag
    16801 aaaagctagt attaacacat atctactccc aagattggaa attatatcac aatatgaaaa
    16861 tgattggtta tttacttagt agttaacgtg tgtctccaag gaaggcacac gttaaattaa
    16921 tggaacaatg ggcgagtttg taaccaaatt acagcagttt tcatatattt gaaccacatt
    16981 tgttgtaagg gcacagcatt gctgtgccct tactgtgtgg tctattattc agccattctt
    17041 tagatatgaa gtagacatta aactaaaagc tagttaaatg tttgcttgtt gacgttgata
    17101 taatgaccaa tacaaaccct tttgttgcaa cagctgtgag tgagtaccac gttcagcaat
    17161 tacaccttgc tctaatacca aaatcaaatc agcacgtttg aggggagcaa agcggtgagc
    17221 aatcaagaac acggtacgat tagcggaaat tttttgcagg ttttgcagta cttgttgttc
    17281 agtttcacta tccaaagcgc tggtagcttc atctaaaact aaaatcggcg cttgggaaag
    17341 aaatagtctt gctaaggcaa tacgttgtct ctgtccacca gataaagcgg taccacgttc
    17401 accaacattg gtttcgtaac cgtagggtaa ttgactgatg aagtcgtgtg ctactgctaa
    17461 ccttgccgcc tctactactt gctctgcggt aatgtcggga ctaccaagag tgatattttc
    17521 taaaatggaa ccgttgaata aaaagtcttc ttgaagaacg acactaactt gttgccgcag
    17581 tgaggctaag tcggcacttt ttatatcaaa accatcaatg aggatacgtc ctgattcaat
    17641 ttgatagagg cgttgtaaaa gtttagacag ggtacttttt ccagaaccac tgcgtccgac
    17701 aatgccgaca aattgccctg gttcggcatt gaaagatatc ccccgcagaa ttgcttcaaa
    17761 gtttggccgg tagcgaaaaa atacttgctc gaaggtgatt tgtcctttca gaggtggtaa
    17821 aactagacca gttcccagtt ctgcttctgg ggagacgttg agaatatcac caatgcgatc
    17881 tactgaaagt agcacttgtt ggaggttttg ccacaactgt actaaacgca aaagtgggcc
    17941 tgtgactctg ccagacagca tttgaaaggc gactagctgt ccaattgtaa gcttttgttc
    18001 gataactaac ttggcaccaa accagagaat cagcatggta gacaaattgg taagaaagtc
    18061 accaatgttg ctgctgatat tggaggtggt ggaggcttta aaacctgtgc gaatgaagcg
    18121 agcaaataag ccttcccagc gatcgcgggc tactggttcg gcggcatggg ctttaacgga
    18181 gtgaattcca gtgattgtct ctactagaaa ggattgacta tcggcagaac ggttaaaagt
    18241 ttcgttgagc cagttacgca gaatgggggt tgaaacgata gttaatgtgg caaatagcgg
    18301 cagtactgct aaggcgacaa aggtgagtgg gacgttatag taaaacatca ataccagata
    18361 caccacagta aagatgctat ctagaattac tgttaatgct gtacctgtga gaaactggcg
    18421 aatttgttcg agttcctgga ctcgtgctac tgtgtctccg acgcgccgcg actcaaaata
    18481 agctaatggc agacgcatca gatggcgaaa tagctgtgct gataaactca aatccagccg
    18541 ccgagctgta tgggtaaaga tgaataggcg cagaataccc aatatggact caaatacagc
    18601 tacgcacaaa agtgcgatcg ccatgacatc aagagtcggc aaactccctt gcaccatcac
    18661 tttatcaatg acgacttgcg taattagggg tgttgttaac cccaaaagct gcaaggtaaa
    18721 agatgctaac aatacttcta cgagtaagcc cttatacttc caaactgctg gggtgaacca
    18781 attgaggtta aatttttctt gccgagatac gagttctact tgccataatt gtccatccca
    18841 agaggcttca actatggact gtggcaagct ttcacaagtt ctttcgggat tgagaggatt
    18901 agcgataatt aagcgatcgc ccttaactcc ataagccacc acccaggatg gactctgggg
    18961 tgagtcagaa ctccacagca gtaaagctgg aaatgacaac tgccgcaact cgccccaact
    19021 cacttgtaac cgccgcaaca ctaaccctaa tttttctgct gcttccacaa cctgttttgg
    19081 gcgttgtcct ctgagttggc gctgcaccca ttccagttgc acagaatttt ctaactgttg
    19141 ggccaccatt gttaaacacg ccgcagcagt attccaacta gcaacaaagg gataatttgc
    19201 aacgatcaga ttagcagctg ggagtccttt ttggggttgg aggctgtggg ggctggaagt
    19261 tccatccgat gttgatgata ttactgaagg ggtggaagag aaggaaaatg tctccctttc
    19321 tccttctgtt tgtactggta atgcttgcca aaactcttga atttgtgggt gagaaaattc
    19381 tgtccaaagt gcagtatccc aacaaattac tatcacttct ttactagcag ctacagcttt
    19441 aaaatccgca gacagctttt gtaagtcgcc aaaccaatcc cccgcatcta gggcagctat
    19501 tggtttgcca atgccttctt ctcgcaagcg gacttttcca gccacaatta agaattgata
    19561 accaccgaca tcatttgacc agattttttc cccaagacga tactggcgag tttgggattc
    19621 attttctaat tgggattttt gttcgggagt cagccagcat aacggtggct gattccaagg
    19681 caaagaagct agaactttta atcgtaaaga ttcattatcc agaattttta actcacttgt
    19741 aacttgactg tcagtttttg aattttctct gctagccatt tttcaaataa ctcattttgt
    19801 agtacttgct gtagttgagt atcttctaaa gacgctggca gaaattgttc tactcgaaac
    19861 aaaccaaaag gtccttctcc ttggggagag tctttgccaa cgatttctat tgggcctacc
    19921 aattgtcctg gactagcgac atcaatagct gcgcgtaata tatccggcat actgcctcgg
    19981 ctgacgattc ccatcatgcc gtttacaatt cggtcatctg aaagtgaata ctctttggct
    20041 agttgctcaa aactacctcc ttcttcaatt tgggtatgga gttcgtctgc caattctcga
    20101 ttattgacaa caatccgaga aagtactacc cgatccaaaa aaattttgcg ttcaatgaaa
    20161 tattcttgga tttttgtttg cgttactaca gctttcagct tttctaactt gtaaccaaaa
    20221 gtcaccgatg tgtgaaatgt agcgtaatct gtgttgttga tctttaacca ttcttgaaaa
    20281 ctttcgggat cagtcagttg atttttcagc ctaaagtcaa taattgactg ttcagttatt
    20341 gctgtgccaa tttcaatatc gtttcgtgtt ctgatttctt cctcaattac gtactggcgg
    20401 agaatatccc caatgaactg tcctaacttt ccagaggctt gcaggtactt tactgcttcc
    20461 tcaacagaaa ttatttggtc attaattgtc aaaaatgatg aagattccat gaactaatta
    20521 tgtgaatatg gttaaacact tataggactt ttaatttaaa tcatatagaa atcatctggt
    20581 tgttgatgga taaatatgat aaagattcca tgaactaatt acatctaaat ggtcaaaaaa
    20641 ttatataact agtgaataat ataatttctc ttgatctctt ttacagtctg gtggggacaa
    20701 aacaggattg aactggggac tggggattgg agattgggat tagggattgg ggattgggga
    20761 ttggggaaga agtaagggag caggaagcaa gaagcaggga gaagaatttt cccctcagcg
    20821 agagcagcat ctgcccctct acctcttttc aatgccccag ctagttattt tcactgattt
    20881 acttaatgaa atttatccat gtcaaggtaa gtagcacaga ggcgatcgca ccg
//
