LOCUS       NZ_CP054919            25061 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Kitasatospora sp. NA04385 chromosome, complete genome.
ACCESSION   NZ_CP054919
VERSION     NZ_CP054919.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora sp. NA04385
  ORGANISM  Kitasatospora sp. NA04385
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 8400742)
  AUTHORS   Zhang,B., Shi,J. and Ge,H.
  TITLE     Genome mining for natural products
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8400742)
  AUTHORS   Zhang,B., Shi,J. and Ge,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2020) Institute of Functional Biomolecules, State
            Key Laboratory of Pharmaceutical Biotechnology, Nanjing University,
            No.163 Xianlin Avenue, Nanjing, Jiangsu 210046, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. v2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013364235.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 08:11:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,532
            CDSs (total)                      :: 7,423
            Genes (coding)                    :: 7,206
            CDSs (with protein)               :: 7,206
            Genes (RNA)                       :: 109
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 218
            CDSs (without protein)            :: 217
            Pseudo Genes (ambiguous residues) :: 0 of 218
            Pseudo Genes (frameshifted)       :: 81 of 218
            Pseudo Genes (incomplete)         :: 153 of 218
            Pseudo Genes (internal stop)      :: 9 of 218
            Pseudo Genes (multiple problems)  :: 25 of 218
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:10:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6120447
            Orig. end                         :: 6145508
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054919.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25061
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="23"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25061
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25061
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15061](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15061
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(67..82)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     gene            174..1181
                     /locus_tag="HUT16_RS27205"
                     /old_locus_tag="HUT16_27205"
     CDS             174..1181
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27205"
                     /product="hypothetical protein"
                     /protein_id="WP_176190682.1"
                     /transl_table=11
                     /translation="MILRLRHKAARWEEQRHPRDHQGRFAEHVGAGHVTLPGTRTEGQR
                     VSTADLLGSRYRPAGTVKAAMCDSLAQAMNSVLDDVLSDQQRDRLTRVRDGRLAAYRPE
                     SGNNGYAEYVEQADLDSGARREPWGYQRMSSEEYHQFVRAEAVSRLVTGWASTANDHDP
                     DALALQDAAQRTFHLDGTLGWNHGDDDLAAETDRVTRDRGHVLDTFLTAMWENTQQHFA
                     ALGVTHVTVHRGFTGDYDDSHLQDLDGHGSVTGLPLRPLSSATTDEETARDFSTQGGEV
                     SGYLISGDIPVTRVLAVPGTGIGCLDEAEVVILAGPGEWYAEEVYPSDDDGWHD"
     gene            1246..2397
                     /locus_tag="HUT16_RS27210"
                     /old_locus_tag="HUT16_27210"
     CDS             1246..2397
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27210"
                     /product="hypothetical protein"
                     /protein_id="WP_176190683.1"
                     /transl_table=11
                     /translation="MAGRTPSSTLDHKQAAPLGVLETDDDEGTFTTLVSVTGLLDHDND
                     VIEPGAYARTLAAMTPKGVWSHDWNVWTARTEHAEELLPGDPRLPAALPDGTPWPAEAG
                     ALLVKGRCNLATQAGRDMYANLQFFAHQVQWSIGYKVRTAKRVRGARRISDLDLYEYSP
                     VLFGANPYTSTLDLKQQGGKARAYLSDADLELAPLAGTLEERIDTIARAVEQHLQQATD
                     GDGVEVGTVQIIGTYPDKVVATVWAFTADGYTSAAWEVPYTLDGEGTPTVGPPAPVRLV
                     LDVEQDGPAAALAALAPDLERVASHMKVLTAAAGKAGRVLSGDNADRLAAAAQHLVAVL
                     DAAGIEWQSAPAPDEGKGRNVETLSPAEIAAALTLFADATDRG"
     gene            complement(2423..3001)
                     /locus_tag="HUT16_RS27215"
                     /old_locus_tag="HUT16_27215"
     CDS             complement(2423..3001)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27215"
                     /product="hypothetical protein"
                     /protein_id="WP_176190684.1"
                     /transl_table=11
                     /translation="MVPVESGWALRIIGSAEESFGPCSTPEAAESWMHEWAAWRLWPLA
                     QARGPWGCLARADGGWMTALARTGLPPVVEAHSAVQHAEEHAARHLISPAAWAAGPDGL
                     PEAVREIEVRFWVREGYRVLAAWATADLGALAREAYRQQQLGRGNFPVSELAARLGVSS
                     ATVSGAAAGRTWNPQISPAAGVLAPRPRR"
     misc_feature    complement(3268..3285)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.35"
                     /tool="antismash"
     gene            3407..4729
                     /locus_tag="HUT16_RS27220"
                     /old_locus_tag="HUT16_27220"
     CDS             3407..4729
                     /GO_component="GO:0044423 - virion component [Evidence
                     IEA]"
                     /GO_function="GO:0005198 - structural molecule activity
                     [Evidence IEA]"
                     /GO_process="GO:0019068 - virion assembly [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01554.3"
                     /locus_tag="HUT16_RS27220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27220"
                     /product="phage major capsid protein"
                     /protein_id="WP_176190685.1"
                     /transl_table=11
                     /translation="MPTTVDNARLKELNSALRTKAAELDTISTAFTVEDGGVTVSTEKA
                     AAFRKALADAQEIKQLITDLEGAAAIQTFLNEPASSPLAPRDAALTAHLAGQNAKSLGE
                     RFIDSSEFKSLAAAGFRGSFDQIVTIEGSGLHQLARKDVFSRSAGTAAVLGLGTPEQLE
                     MVPRPLRPGRIRDLFPSETTTANILYGVRVTGFTNGAAVVPERTMEVPAGGGAAVEVYA
                     RAPQSQLTFKTVLYPVAEIAHTMPIHKNTLADEPRLRGIIDTELVDGVKMVEDNEILYG
                     PGGDDSITGIVNTQGVQTYAQDAADKQTAAIRRAATRAVLANYPPTGIVLHPFDFEDLE
                     LETDGQGAYRVAVNVAIGAQKIVWRLAVVDSMAINEGKFLVGSFGLGARLYDREQVGVQ
                     VSTENRDNFERGVVTMRGSERIGLEVPRPESFVYGTFKAAA"
     gene            4729..5187
                     /locus_tag="HUT16_RS27225"
                     /old_locus_tag="HUT16_27225"
     CDS             4729..5187
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27225"
                     /product="hypothetical protein"
                     /protein_id="WP_176190686.1"
                     /transl_table=11
                     /translation="MATRKPPAKTTAPVPAATPAPETAAPAAEQPATAPIPAAEASAAA
                     PLEPPPAPPEQPEPRPEGPVPGFTLQAPASAADSELVDENGSPLPDDPGELFDLTHPEW
                     TVVFPRVRIYERRTVPGSRRTATHLLYIPAKSVPRAEFDRLRQARGWE"
     gene            complement(5340..5855)
                     /locus_tag="HUT16_RS27230"
                     /old_locus_tag="HUT16_27230"
     CDS             complement(5340..5855)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019886598.1"
                     /locus_tag="HUT16_RS27230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27230"
                     /product="N-acetyltransferase"
                     /protein_id="WP_176190687.1"
                     /transl_table=11
                     /translation="MTIALRRFQAGDLPEDHRQTLLDVHSDAYKDQADDPFVQRFGWFA
                     QHWTNRPGYTCVMAYDGTEAVGFSYGAPLEPGREWWRQHLLPEPAETSTFAVSEVMVRP
                     AWRKQGIAEQTHEALLADRPEALAVLYVDVTHPRVQAMYEQWKYTKVGEHRPFEDAPLY
                     AVMVRSLR"
     gene            complement(5852..7102)
                     /locus_tag="HUT16_RS27235"
                     /old_locus_tag="HUT16_27235"
     CDS             complement(5852..7102)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717707.1"
                     /locus_tag="HUT16_RS27235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27235"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_176190688.1"
                     /transl_table=11
                     /translation="MGDNTDLRDLMKERGLNRPGLASLVNKELAKMGCPGTVSVRTIAN
                     WLSGKTQWPQGRIQVALFRALGRTPEQLGFIPPPGAVACHAPPEEPVHRRNFLVASATL
                     PLAASTPSRTVGHSDVDRLRASLDTLTALDDHRGGHGSLESASLAGAEQALELQRNAVG
                     ESVQKRLYGLAAEYTATAAFSSIDSRQFDRAEQLLDRTLRLAGLGRDHATMFRAYNLLA
                     MIGYHRNSPSGSLVAAQAAQATQATRRDPFLASLGHARTAIALSAAGDRQAALRSLGYA
                     NESLHRADERPRPGWTTFYGSAELEALSAVVHQQLGDSPGSERSSHRAIAGIPPQFRRN
                     RSLATARLALAQLGQNDLDQACKTASQVYTLMGTDPLPPRLRSLLGDFHRGLITLAPDA
                     AVTQEWTDRVRAQGDTQ"
     gene            7333..7812
                     /locus_tag="HUT16_RS27240"
                     /old_locus_tag="HUT16_27240"
     CDS             7333..7812
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="HUT16_RS27240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27240"
                     /product="ATP-binding protein"
                     /protein_id="WP_176190689.1"
                     /transl_table=11
                     /translation="MLADRPQGTTQSESRPFGPVDSRHRFSEREFVSEFESVGVVRRWA
                     RQVLTDCGWEPDSEAVSDFLVVLAELVTNAVVHAQVPGRSVLVRLRQVGDGCRVEVVDG
                     RPDLMPQTDLLPREESGRGLLLVRDLAAAMGVERSGEDKIVWAKVHHQGQLRTAA"
     misc_feature    7829..7847
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.12"
                     /tool="antismash"
     gene            7983..8330
                     /locus_tag="HUT16_RS27245"
                     /old_locus_tag="HUT16_27245"
     CDS             7983..8330
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27245"
                     /product="hypothetical protein"
                     /protein_id="WP_176190690.1"
                     /transl_table=11
                     /translation="MGRAYWCEVTALVHGAGRRMVLATFEASSPRVAMLWIVTRLREMA
                     EQFDPQDAHWARQVFSIAEEHEAAMAAMVFGEDFALTLLVDQVVYVFSAGASTGLEARL
                     PGRSGRLVAAR"
     gene            8447..9676
                     /gene="fxlM"
                     /locus_tag="HUT16_RS27250"
                     /old_locus_tag="HUT16_27250"
     CDS             8447..9676
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571590.1"
                     /locus_tag="HUT16_RS27250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27250"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_176190691.1"
                     /sec_met_domain="PCMT (E-value: 5.6e-34, bitscore: 116.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTLSEIVGPGAHRADALRLEMVVALRKLGTVRSDAVAKAVLTVP
                     RHVFAPESSLAEVYEPERALVTKRNEHGLAVSSVSAARIQAQMLEQADVRPGMRVLEVG
                     SGGYNAALLAELVGPEGEVVTVDIDPFVTERAQKYLAEAGYGRVRVVLADGSEQVEGGP
                     FDRIVVTVGAWDLPPAWTGALVEGGTITVPLRMRGLTRSITFRREGERLVSVSAEVCGF
                     VKIQGADAHDEFLVLPRGTKEIGLRFDELERPDTSRLGGALETPRAEWWTRVTVGNREP
                     FDSLYLWLASSLPGFGLMSVDPELDTKMVAPANRMACPVIVEGGSLAYLALRKITDEPT
                     TFEFGAHGFGPEGGPLAALINTEVRTWDREHRGGDGPVFTAYPAGTPDDRLPDGLVIDK
                     THVRLTISWP"
     gene            9721..9885
                     /locus_tag="HUT16_RS27255"
                     /old_locus_tag="HUT16_27255"
     CDS             9721..9885
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="HUT16_RS27255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27255"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_176190692.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.4e-16, bitscore:
                     58.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQSLTGTVAAGDFDLDVTIVEGADPVAALLRSTDDGCGSTCEGS
                     ACASGGGNV"
     CDS_motif       9721..9801
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTQSLTGTVAAGDFDLDVTIVEGADPV"
                     /locus_tag="HUT16_RS27255_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9802..9885
                     /prepeptide="core"
                     /locus_tag="HUT16_RS27255_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="3.30"
                     /molecular_weight="2351.5"
                     /monoisotopic_mass="2350.0"
                     /core_sequence="AALLRSTDDGCGSTCEGSACASGGGNV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTQSLTGTVAAGDFDLDVTIVEGADPV"
                     /leader_location="[9720:9801](+)"
                     /alternative_weights="2369.5"
                     /alternative_weights="2387.5"
                     /alternative_weights="2405.5"
     gene            10001..13039
                     /locus_tag="HUT16_RS27260"
                     /old_locus_tag="HUT16_27260"
     CDS             10001..13039
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="HUT16_RS27260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27260"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_176190693.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.1e-157,
                     bitscore: 522.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.3e-12,
                     bitscore: 45.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-31, bitscore:
                     109.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYEAVGPALLRAAARPAGAGPSWWPDLADTGTHATANWRAWLQHV
                     WSDEVFAAAVEVAAGPQLAARVREVVFNFDHAPRRRLRRLTASVMQYALRQQRPTPFGL
                     FAGVTAVPFGEAAAAPRWGASRAVARPDARWLASVVRELEEAVGDLLPVTANQLRVRRG
                     DRILLPVTCNPQDGEPAELSVRATDPVLAVLEAADGPLSVTLGELADRFPAAPADKVRA
                     MLGELVRQGFLISILRLPTTATDPLGHLLAVARTTGLDQVPAAAAPLDELRSVREQSAR
                     HNESADPVEQRTLRTRLARQQAGRSGEVPSLMVDLHLDAGPAVLPRRVASLMAGAAEVL
                     TRLSPFPDGHPAWVDYHGRFLERFGPGAVVPVVELVNPDTGMGFPARYRHSVLPDVPPR
                     VRRRDAQLMALAQKAAVECLDEVDLDGPLLERLAPSPVPEGVVQPHAELTVRLSADGAV
                     PFTPVVQAVPRGAGTTAGRFLYLLETERRRELEAAIAAAPPLRAGALVVQVSAPPLYAR
                     AENVSRAPALLPLLTLGEYPQIGSVLRLEELGVCADERRMWLVRLADRRPVEVRVLNAV
                     DFRANTDPLVRFLCEITGAHTPWLTAFNWGAAGRLPYLPRVRYGEVVLSAARWHLPAAD
                     LPGKDAEWEQWRAAAGEWIARYNVPAAVYLSQSDLRLPLDLRLPEHLVMLREHLLREPT
                     AILIEAPRADDNRWCGRAHEITVQLHSTRAPLPAAHPRPGRPATVRSGHLPGASGWLSA
                     RLFGNPRRADELLSRVEGLAADWVVPPQWWFLRHTDPEPHLRLRVPVSAVAAWSLAAER
                     IGRWAEQMREEGLLTRMEIDTYLPEAGRYGRGAALRAAEAFFAADSRAVLAQLAYQRAT
                     STDPATVTAASMLDLATALLGEQAGHAWLLERVPRHSGIALPRSAPRLVAEFADRPERL
                     ALTEEGRALALVWEVRAKKLVDYRRALGRDGELETADVLGSLLHLHHARAVGLDAASER
                     ICHRLARAAALTLTARAQEGQPA"
     aSDomain        10457..10714
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HUT16_RS27260_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.00E-14"
                     /identifier="RREFam001.1"
                     /label="HUT16_RS27260"
                     /locus_tag="HUT16_RS27260"
                     /protein_end="238"
                     /protein_start="152"
                     /score="45.0"
                     /tool="antismash"
                     /translation="VTANQLRVRRGDRILLPVTCNPQDGEPAELSVRATDPVLAVLEAA
                     DGPLSVTLGELADRFPAAPADKVRAMLGELVRQGFLISILR"
     gene            13036..14193
                     /locus_tag="HUT16_RS27265"
                     /old_locus_tag="HUT16_27265"
     CDS             13036..14193
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="HUT16_RS27265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27265"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_176190694.1"
                     /sec_met_domain="LANC_like (E-value: 2.6e-37, bitscore:
                     127.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAELLAPPTQASAQWGQSLAKGGLATALLHIERAATGRGDWDTA
                     HEWITACVSQPVNSFAGASVFYGAPAVAHVLHLATMHGPRAYHQPRMLLDAAVEHVVEQ
                     RLAAAHRRIDAGQRPAFHEFDLLGGLTGLGAHLRVRGRQELLREVLAYLVRLTEPVQGR
                     SGWWTHLAPSGEQDERYPGGHGNFGIAHGIPGPLALLALAHLDGTRVPGHLEAIERILD
                     WLDAWQQNGAARAWWPEAITAAEADQGRARQSKPLRPSWCYGTPGVATALHHAARATGD
                     PARARTAEAAFLDALEDPDQVHSLTDETVCHGTAGVRLAARRFAERTDHTTAVRILAAA
                     STLPAPVPAATGQGLLEGTAGISLARCSLAAETPGTGWDALLLLV"
     gene            14219..15061
                     /locus_tag="HUT16_RS27270"
                     /old_locus_tag="HUT16_27270"
     CDS             14219..15061
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="HUT16_RS27270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27270"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_176190695.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.8e-28, bitscore:
                     98.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLATGDRAWTQVHLHLATDTPEEHAVRLLGPALISLEDQGLIDCW
                     HFLRKGDRWRLRYRESASGILGAATTAFAVNEALDMCREAGMISDWTPALYEPETYAFG
                     GAAALPAAHRLFHQDSRHALIYLAAVHRGELPDQRAELWLLLGTAAMRGAGLDWYEIGD
                     TWAQVAENRPRLSVPDRRLVDAARTLLRADTAPGSALLEGRLAHAAGWFGAFAVHGLTL
                     RALADEGQLWRGQRAVLAHHQLFTANRLGLPHQQQAALASAAAGAVLDLVDADEAVLR"
     misc_feature    complement(14220..14235)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     gene            15058..16191
                     /locus_tag="HUT16_RS27275"
                     /old_locus_tag="HUT16_27275"
     CDS             15058..16191
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27275"
                     /product="hypothetical protein"
                     /protein_id="WP_176190696.1"
                     /transl_table=11
                     /translation="MTTQRTAQPTGPLGDALARLPLVPRRHALATPLEQRVQRLTDLAR
                     QAADTENPTTATSVHNLAALLASDRGLPGLARVLCLNHAGFYLAHRPLTADLARLALEP
                     LVNLAHLELRAGNGMPALAILDELTRAVADNDDATLGGLVVPLAGLTASSVDRGNVHEW
                     LSDIRVFGGARALVRAGRWSDARLHLQQSTAPGDRLFEARQVAAVAMAIEGRTALARTL
                     ACNTPAEEPWEHAIAAALTAACTLLDGAPAAEQTETLLHAHSAVAPQDGSAVFDTRLAL
                     TVADLATAAGQLPDAARVYLTAVGRTIAAPEGYSARDLARHPLADGLPPQQRRQLAAIA
                     ADSGVGGPATLTTDHDDRITAALALAAAVIRSAGTGR"
     misc_feature    15271..15273
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16188..16790
                     /locus_tag="HUT16_RS27280"
                     /old_locus_tag="HUT16_27280"
     CDS             16188..16790
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014043612.1"
                     /locus_tag="HUT16_RS27280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27280"
                     /product="hypothetical protein"
                     /protein_id="WP_176190697.1"
                     /transl_table=11
                     /translation="MNRAADADRVERLALFGALLSAFGEIHPACDQWAQDSTTAWCKRL
                     SGKHLVYRDGVRVGDESDDRGGEPTMTADARARRAVAVHVATYTAIQSGAALALTRAFG
                     YRVPASALLAGAAINAVTHAAIDRGPLLLWLADRTRLRGYIEHCQAVRLDADGEAHAEV
                     NGPGTAWFELDAALHRAVGVTAAAVTTWLATRRTYRR"
     gene            16943..17917
                     /locus_tag="HUT16_RS27285"
                     /old_locus_tag="HUT16_27285"
     CDS             16943..17917
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.4"
                     /locus_tag="HUT16_RS27285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27285"
                     /product="phosphotransferase"
                     /protein_id="WP_176190698.1"
                     /sec_met_domain="APH (E-value: 7.1e-12, bitscore: 44.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATGTSTAAPARSTHQHPARAARTALHHAAALAGLDPAGAQLLH
                     QGRNFVFRLRGGVIAKVHHRRRYADVQRDARAAQALLAAGIPTAAPFGDGRPITAGGLV
                     VSFTEDLGTTEPTWGQLAEAAACLHHIPPLAGLGLPLIDKITSAARRITLLPSSVISET
                     ERARLLALLTRTADAYTSITWPAPRTVHGDLNPGNGALLASGGTALLDLETLSIGHPGF
                     DQAAAAFARDAFGLDPSVHEDWVDNYGYDITTAAGGLPYRTISMLLGISAYLFYAELGT
                     QGRPEVLPQARHRLDTLLANRQFPWDWAPANPVRAAAAAGTAG"
     gene            18030..18617
                     /locus_tag="HUT16_RS27290"
                     /old_locus_tag="HUT16_27290"
     CDS             18030..18617
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27290"
                     /product="hypothetical protein"
                     /protein_id="WP_176190699.1"
                     /transl_table=11
                     /translation="MELIVTAEEVARRLGLSVPLTDEVRQRVETAVEDAQETLVAHLGR
                     PLLPVQYTESGIRAGTSGWNLSHAPVITVISAVPDATSLPTPSFGTPTYTVTYIAGIDA
                     STDPETAPLRLWVRATACHHPLLADAPLRQRRIASASVEGQSVTYDTAVEPPVLLAPPD
                     LTTTDRWRLRGRRVYQDPVRPNPPGLTVPGGP"
     gene            18617..18958
                     /locus_tag="HUT16_RS27295"
                     /old_locus_tag="HUT16_27295"
     CDS             18617..18958
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535802.1"
                     /locus_tag="HUT16_RS27295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_27295"
                     /product="hypothetical protein"
                     /protein_id="WP_176190700.1"
                     /transl_table=11
                     /translation="MGVLLADRQLGVRTRGAPGLDAHGAEVTGPPGPLRGPWPGRALPQ
                     PDGTWHLALDPQAGTLLVGDLVVEPASGKEWTVTAADDLVHAADPALAYVRVTARSRQA
                     GGTRAEGHP"
     gene            18958..19428
                     /locus_tag="HUT16_RS27300"
                     /old_locus_tag="HUT16_27300"
     CDS             18958..19428
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27300"
                     /product="hypothetical protein"
                     /protein_id="WP_176190701.1"
                     /transl_table=11
                     /translation="MARLELPADIAERLAPLLRRHTERLAEEVAEEARRRAPAAKTWHT
                     QEDGNARPSHQAADGQTVPAPLPFSVGNTTLDRPRDPDGPVEETAGCRCTVTEDPEAVA
                     AAITAGKAATSGTRVRATVTCDYPRAAEAEYAHGDGSHFMGAAASEVANRHR"
     gene            19536..19790
                     /locus_tag="HUT16_RS27305"
                     /old_locus_tag="HUT16_27305"
     CDS             19536..19790
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27305"
                     /product="hypothetical protein"
                     /protein_id="WP_176190702.1"
                     /transl_table=11
                     /translation="MAAAPGTVRITLAHHFDRDGAQLLPGDEIDVPTHEARKLITAGYV
                     AGVDPNDPEAVAKALAPAIERKPSMAKPPANKAAGPASE"
     gene            19783..20211
                     /locus_tag="HUT16_RS27310"
                     /old_locus_tag="HUT16_27310"
     CDS             19783..20211
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27310"
                     /product="hypothetical protein"
                     /protein_id="WP_176190703.1"
                     /transl_table=11
                     /translation="MSDLASLDPEELAVTWLSGHAELTGALGGPGRVGARNTPPYPRIR
                     ITQVPGGSAPGWRWTATFHLQVEALGDLDRSTPRPELRKAFTVAVKALHELAGQQAVPG
                     RPVVTAVRALSAGGWLPEPTGQGRYLVIVAVTAHPPTR"
     gene            20331..20897
                     /locus_tag="HUT16_RS27315"
                     /old_locus_tag="HUT16_27315"
     CDS             20331..20897
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27315"
                     /product="hypothetical protein"
                     /protein_id="WP_176190704.1"
                     /transl_table=11
                     /translation="MPAESMFVAQMARLYLAVPGTVAPADPLVALPTGWKEAGLFKPGS
                     LEWNTDPKFEKLRSHQLRYAARTIQTEDAATVKVELQEWNANNICAVYGGGEVTTVTQD
                     SKTFYRYTPPKVGGRKQFAAVVELIDGSKHYRRIVPLCEQVAAVNQKFPDDAESTLPLE
                     LAIIGGESTDPWYDLTDDPGFAPAA"
     gene            21169..21714
                     /locus_tag="HUT16_RS27320"
                     /old_locus_tag="HUT16_27320"
     CDS             21169..21714
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27320"
                     /product="type II toxin-antitoxin system CcdA family
                     antitoxin"
                     /protein_id="WP_176190705.1"
                     /transl_table=11
                     /translation="MAKVSVSIPDELLERAQALHQQDNVSQLVQKGLALLAPEKKQPYR
                     PEWAKAGLAEVADRLRAAAREDYEEGYRAGFELAKVAPWDWLVWLASWRFDLKRVLSIH
                     RKARYDNDYSAFQEIAAAQRSAPGWSGDWYQSLAEAFPAEFAEPGSEDCLERSGQFLAG
                     AMQALRDVWDYANQPIGQ"
     gene            22281..22874
                     /locus_tag="HUT16_RS27325"
                     /old_locus_tag="HUT16_27325"
     CDS             22281..22874
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27325"
                     /product="hypothetical protein"
                     /protein_id="WP_176190706.1"
                     /transl_table=11
                     /translation="MAGIDLDAARRRRLAAAAEKAQAAKAEYTVGEEPVIFGGVTVAVL
                     PAELPLAVWEPLIGIPYLPLLLRSLVEAAQSQGEQQTQAAGLIVDVLGSEPTLPSDLLT
                     AAADMGRRLLGEDGFTRLMEQRPSHTDVFELVRALSAKYFSGGAGLGELMGPSGSPSSG
                     GTTSKPTSSGTTGSTPAVPGGVPVTLDSSAPAAS"
     gene            22880..23146
                     /locus_tag="HUT16_RS27330"
                     /old_locus_tag="HUT16_27330"
     CDS             22880..23146
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS27330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_27330"
                     /product="hypothetical protein"
                     /protein_id="WP_176190707.1"
                     /transl_table=11
                     /translation="MRGLPADALLRRPAADAGTDRWGLTEELLAQLVEMVSVFAADRRL
                     LKPVELPRPAHLKAAARERGGDAQGMARAVGVLRRSGRAVRRG"
ORIGIN
        1 accgggctcg ggtgcctgga cgagtcggaa gtcgtcatcc tggccggccc cggtacctgg
       61 cgctgggaga cggcggagtg accggtcagc ccggcacggc cccgacccgc ggtacccgtc
      121 ccggtcggct ccacccggat gcgggcggag ccgaccggct gcgccttccg gcggtgatcc
      181 tgcggcttcg gcacaaggcc gctcggtggg aggaacagag gcacccacgc gaccaccagg
      241 gccgcttcgc cgagcacgtc ggagccggcc acgtcaccct ccccggcacc cgcacggagg
      301 gccagcgcgt cagcacggcc gacctcctcg gcagcaggta ccggcccgcc ggaacggtca
      361 aggccgccat gtgcgactcg cttgcgcagg cgatgaactc ggtgttggac gacgtgctgt
      421 cggaccagca gcgcgaccgc ctcacccggg tccgggacgg ccgccttgcc gcataccgcc
      481 ccgagtccgg caacaacggg tacgccgagt acgtcgaaca ggccgacctc gacagcggcg
      541 cccgccgcga gccgtggggc taccagcgga tgagcagcga ggagtaccac cagttcgtcc
      601 gggcggaggc ggtctcccgg ctcgtgaccg gctgggcgtc caccgccaac gaccacgacc
      661 cagacgccct ggcgctccag gacgccgccc agcggacctt ccacctcgac ggcaccctcg
      721 gctggaacca cggcgacgac gacctggccg ccgagaccga ccgcgtcacc cgcgaccgcg
      781 gccacgtcct cgacaccttc ctcaccgcga tgtgggagaa cacccagcag cacttcgccg
      841 ccctcggcgt cacccacgtc accgtccacc gtggcttcac cggcgactac gacgactccc
      901 acctccagga cctcgacggc cacggcagcg tcaccggcct gccgctgcgc cccctgtcct
      961 ccgccaccac cgacgaggag accgcccgcg acttctccac ccagggcggg gaggtcagcg
     1021 gctacctgat cagcggcgac attcccgtca cccgcgtcct cgcggtaccc ggaaccggca
     1081 tcgggtgcct ggacgaagcc gaggtcgtca tcctggccgg tcccggggag tggtacgccg
     1141 aggaggtgta tcccagcgac gacgacggct ggcacgacta ggcggcgcga cccaagcccc
     1201 gtccggcccc taccgtcacc cgcaccaacg aacgggagcg agacggtggc aggacgcacc
     1261 cccagcagca cactcgacca caagcaggcc gccccgctcg gggtcctgga gaccgacgac
     1321 gacgagggca ccttcaccac cctcgtctcc gtcaccggcc tgctcgacca cgacaacgac
     1381 gtgatcgagc ccggcgccta cgcccgcacc cttgccgcaa tgacccccaa gggtgtctgg
     1441 tcgcacgact ggaacgtgtg gaccgcccgc accgagcacg ccgaggaact gctgcccgga
     1501 gacccgcggc tgcccgcggc cctccccgac ggcaccccct ggcctgccga agccggcgcg
     1561 ctcctcgtca agggccgctg caacctcgcc acccaggccg gacgcgacat gtacgccaac
     1621 ctgcagttct tcgcccacca ggtccagtgg tcgatcggct acaaggtccg caccgccaag
     1681 cgcgtccggg gtgcgcgacg catcagcgac ctcgacctgt acgagtactc gccggtgctg
     1741 ttcggtgcga acccctacac ctccaccctc gacctgaagc agcagggagg gaaggcccgc
     1801 gcctacctgt ccgacgccga cctggaactg gcaccgctgg ccggcaccct ggaggagcgg
     1861 atcgacacca tcgcccgcgc ggtcgagcag cacctccagc aggcgacgga cggtgacggt
     1921 gtcgaggtcg gcacggtgca gatcatcggc acctacccgg acaaggtcgt cgccacggtg
     1981 tgggcgttca ccgccgacgg ctacacctcg gcggcctggg aggtccccta caccctggac
     2041 ggcgagggca ccccgaccgt cgggccgccc gcaccggtgc gcctggtgct cgacgtcgaa
     2101 caggacggcc cggccgccgc gctcgcggcg ctcgcgcccg acctggaacg ggtcgcgtcc
     2161 cacatgaagg tgctcaccgc cgccgccggg aaggccgggc gggtcctgtc gggcgacaac
     2221 gccgaccgcc tcgccgccgc cgcccagcac ctcgtcgccg tcctcgacgc tgccggcatc
     2281 gagtggcaga gcgcccccgc tccggacgag ggcaagggac ggaacgtgga gacgctgagc
     2341 ccggcggaga tcgccgccgc gctcacgctg ttcgctgacg ccaccgaccg cggctgagcc
     2401 cgcgctgtcc ggcggcgcgt gcctaccggc gcgggcgagg ggcgagaacc ccggccgccg
     2461 ggctgatctg tgggttccag gtccgcccgg ccgccgcccc ggagaccgtc gccgacgaca
     2521 cccccagccg cgccgccagc tccgacaccg ggaagttgcc ccggccgagc tgctgctgcc
     2581 ggtatgcctc gcgggccagc gccccgagat cggcagtcgc ccaggccgcc aacacccggt
     2641 agccctccct cacccagaac cgcacctcga tctcgcgcac cgcctccggt agaccgtcgg
     2701 ggcccgcagc ccaagccgcg ggcgagatca ggtgtcgggc ggcgtgctcc tccgcgtgct
     2761 gcaccgcaga gtgcgcctcc accaccggcg gcaggccggt gcgggccagc gcggtcatcc
     2821 acccgccgtc cgcacgtgcc aagcaccccc acggcccgcg ggcctgcgcc agcggccaca
     2881 accgccacgc cgcccactcg tgcatccagc tctccgccgc ctccggcgtg ctgcacggcc
     2941 cgaacgactc ctcggcggaa ccgatgatcc gcagcgccca accggattcg accggaacca
     3001 cttccaacac ctctccacaa aaagcgagtt ggcggacagg gatgccgacg gggccagcgg
     3061 ctcccgctgc ttcgatcagc ggaagaccag gcttcgggaa ggggtacacg ccggcctcca
     3121 cgagggacgg ccgggctgac cggccggtcc gacgccgtgc cggactccac cacactcacc
     3181 cgcaacagca gacagaagaa caggcaactt cctctaattt caatggagtt gatgatggcg
     3241 actgcaagtg cgccaaccgg taagccctca acgcgacact aacgatcacc agttcctacg
     3301 gtgtgccgat cgccgtggcg tcccggtgct gaccgagcgc acggcgtgga cccttccgtc
     3361 ccgcgctggc ggggtggccc ggcaccatcc caaggagcgc cacaccgtgc ccaccaccgt
     3421 cgacaacgct cgactcaagg aactgaacag cgcgctgcgc accaaggcgg ccgaactcga
     3481 cacgatcagc acggccttca ccgtcgagga cggcggcgtg accgtatcca ccgagaaggc
     3541 cgcagcgttc cgcaaggccc tcgccgacgc ccaggagatc aagcagctga tcaccgacct
     3601 ggagggcgcg gccgccatcc agaccttcct caacgagccg gcctccagcc ccctcgcccc
     3661 ccgggacgcc gcgctgacag cccacctcgc gggccagaac gcgaagtccc tcggcgagcg
     3721 gttcatcgac agcagcgagt tcaagtccct cgccgccgcc ggcttccgcg gctccttcga
     3781 ccagatcgtc accatcgaag gcagtggcct ccaccagctc gcccgcaagg acgtgttcag
     3841 ccggtccgcc ggcaccgccg ccgtccttgg cctcggcacc ccggagcagc tggagatggt
     3901 gccccgcccg ctgcgccccg gccgaatccg cgacctgttc ccgtcggaga ccaccaccgc
     3961 caacatcctg tacggcgtgc gcgtcaccgg cttcaccaac ggggcggccg tcgtccccga
     4021 gcgcacgatg gaggtaccgg ccggtggcgg tgccgccgtc gaggtctacg cccgcgcccc
     4081 gcagtcgcag ctcaccttca agaccgtgct ctacccggtc gcggagatcg cgcacaccat
     4141 gccgatccac aagaacacgc tcgccgacga gccccgcctg cgcggcatca tcgacaccga
     4201 actggtcgac ggcgtcaaga tggtcgagga caacgagatc ctgtacggcc ccggcggcga
     4261 cgacagcatc accggcatcg tcaacaccca aggcgtgcag acctacgccc aggacgccgc
     4321 cgacaagcag accgccgcga tccgccgagc cgcgacccgc gccgtgctgg ccaactaccc
     4381 gccgaccggc atcgtcctgc accccttcga cttcgaggac ctggagctgg agaccgacgg
     4441 ccagggtgcc taccgggtcg cggtcaacgt ggcgatcggc gcgcagaaga tcgtctggcg
     4501 gctcgccgtc gtcgactcga tggccatcaa cgagggcaag ttcctcgtcg gcagcttcgg
     4561 gctcggcgcc cgtctctacg accgcgagca ggtcggcgtc caggtctcga ccgagaaccg
     4621 cgacaacttt gagcgcggcg tcgtcaccat gcgcggctcc gagcgcatcg gcctcgaggt
     4681 gccccgcccc gagtccttcg tctacgggac cttcaaggcg gccgcctgat ggccacccgc
     4741 aagcccccgg cgaagaccac cgccccggtg cccgcagcaa ctccggcccc ggagactgct
     4801 gcaccggcgg cggagcagcc cgcaacagcc ccgatcccgg cggcggaggc gtccgccgcc
     4861 gccccactcg aaccgccccc cgcgcccccc gagcagcccg aaccgcgccc ggaggggccg
     4921 gtacccggct tcacgctcca ggcgccggcg tccgccgccg acagcgagct ggtggacgag
     4981 aacggaagcc cgctcccgga cgaccccggc gagctgttcg acctgaccca cccggagtgg
     5041 accgtcgtct tcccccgggt ccgtatctac gagcgccgga ccgttcccgg cagccgccga
     5101 acggccaccc acctgctcta catcccggcg aagtccgttc cccgggcgga gttcgaccgc
     5161 ctgcggcagg cccgcggctg ggagtagcag ttcgtacggc gggggcccca cacgatcgtg
     5221 tggggccccc gccgtacacg cggacgcctg tgcccgctgc ccgacgacgg cctggtgctg
     5281 tccgcggtgc accaaggcct ccggcgtgcg ttcggacgta cccgctgacg ggctgttcgt
     5341 cagcgcaagg agcgcaccat gacggcgtac agcggggcgt cctcgaaggg ccggtgctcg
     5401 ccaaccttgg tgtacttcca ctgctcgtac atggcctgga cgcgggggtg cgtcacatcg
     5461 acgtagagca cggccagcgc ctccgggcgg tccgccagga gggcttcgtg agtctgctcc
     5521 gcgatcccct gcttccgcca ggcggggcgc accatgacct cggagacggc gaacgtggag
     5581 gtctcggccg gttctggcag gagatgctga cgccaccact cgcggcctgg ttccagcgga
     5641 gcgccgtagg agaagccgac ggcctcggtt ccgtcgtacg ccatcacgca ggtgtagccg
     5701 ggccggttcg tccagtgctg ggcgaaccag ccgaaccgct ggacgaaggg gtcgtcggcc
     5761 tggtccttgt aggcgtcgct gtggacgtcg aggagggtct gccggtgatc ttcgggcagg
     5821 tctccggctt ggaagcggcg gagggctatc gtcactgcgt gtctccctgg gcgcgtacgc
     5881 ggtcggtcca ctcttgcgta actgcggcgt cgggcgccag ggtgatcagc cctcggtgga
     5941 agtcgccgag gaggctgcgc agccgcgggg gcagcgggtc ggtccccatc aaggtgtaga
     6001 cctgggatgc ggtcttgcac gcctggtcga ggtcgttctg tccgagttgg gcgagggcga
     6061 gccgggctgt ggccaggctg cggttgcggc ggaactgggg cgggatgccc gcgatggcgc
     6121 ggtgcgagga tcgttcggac ccagggctgt cgccgagctg ctggtgcacg acggcgctca
     6181 gcgcctcaag ttcggccgat ccgtagaagg tggtccatcc aggtcggggg cgctcatcgg
     6241 cccggtgcag ggattcgttg gcgtagccga gggaccggag cgccgcctgc cggtcgcctg
     6301 cggcggagag cgcgatggcg gttcgggcgt gaccgaggga agccaggaac ggatcacggc
     6361 gggttgcctg ggtggcttgc gccgcctgtg ccgcgaccag cgagccggag ggggagttgc
     6421 ggtggtagcc gatcatcgcg aggaggttgt aggcgcgaaa catcgtggcg tgatcgcggc
     6481 cgaggcccgc caggcgcagg gtgcggtcga gaagttgttc ggctcggtcg aactgccggg
     6541 agtcgatgga cgagaacgct gcggtcgccg tgtactcggc cgccagtccg tacaggcgct
     6601 tctgcacgga ctcgccgaca gcgttccgct gaagttcgag ggcttgttcc gcgccggcca
     6661 gcgacgctga ttcgagagag ccgtgtccgc cgcggtggtc gtccagggcg gtcagcgtgt
     6721 cgaggctggc gcggagccgg tcgacatcgg agtggccgac ggtgcgtgag ggcgtagacg
     6781 ccgcgagcgg aagcgtggcg gatgcgacga ggaagttgcg gcggtgcacg ggttcctccg
     6841 gtggtgcatg gcacgcgact gcgccagggg gcgggatgaa gccaagttgc tcgggtgtgc
     6901 ggcccagcgc acggaagagg gcgacttgga ttctgccttg aggccactgg gtcttgccgg
     6961 acagccagtt ggcgatggtc ctgaccgaca cggtgccagg gcatcccatt ttggcgagtt
     7021 ctttgttgac caggctggcg aggccgggcc ggttgaggcc tcgttccttc atgaggtcac
     7081 gtagatcggt gttgtccccc atgcgctcaa agtagcgcgg cggacacacc ctgcacatgg
     7141 atgatggcaa agggagagtc aaaatttccc tctcggcggc acaggcgagc cgctgctttt
     7201 cactcccctc aaggctggaa cgggcgttga ctgggcgtca gacagcggca gccccgctcc
     7261 tgcaaaccgt ctgccagtgg ccgaaggtcg aaggtgcggc acgcctgttc cgtcgcctca
     7321 aggagagtcc ccatgctcgc cgacagacct cagggcacca cgcagagcga gagccgcccg
     7381 ttcggaccgg tggacagccg ccaccgtttc tcagaacggg agttcgtttc tgagttcgag
     7441 tcagtcggag tcgtccgccg atgggcaagg caggtcctca cggactgcgg ctgggaaccc
     7501 gacagcgagg cggtgagcga cttcttggtg gtcctggccg agctcgtcac caacgccgtg
     7561 gtgcacgcgc aggtccccgg ccgcagcgtc ctggtgcgct tgagacaggt cggggacggt
     7621 tgccgggtcg aggtggtgga cggtcgaccg gacctgatgc cgcagacgga cctcttgccg
     7681 cgtgaagaaa gcggccgggg cctgctgctg gtgcgggacc tggcggcggc catgggcgta
     7741 gagagatcgg gagaggacaa gatcgtgtgg gccaaggtcc atcaccaagg tcagttgagg
     7801 acggcggcat gacggtacga cggccaggtg cggtgaagcg cgccttactc cgcgttctgc
     7861 ggcttcgctg gccgagtgca cccgcgccgg tcgcgccggc gttctccggt accaggttgc
     7921 tgccgcgctg ggcgacgccc ccggttgatc ccagcggcac ggccttcgtg gaggcggagc
     7981 gggtgggtag ggcgtactgg tgcgaggtga ccgcgctggt gcacggtgct gggcgccgga
     8041 tggtgctcgc cacgttcgag gcgtcctccc cgcgggtggc catgctgtgg atcgtgacga
     8101 ggctgcgcga gatggcggag cagttcgacc cgcaggacgc gcactgggcc cggcaggtct
     8161 tctcgatcgc cgaggagcac gaggcggcga tggccgccat ggtgttcggc gaggactttg
     8221 cgctgacgct gctcgttgac caggtggtgt acgtgttctc ggccggggcg agcaccggtc
     8281 tcgaagcccg gcttcccggg cggtccggcc gtctggttgc tgcgcgctga cgtttcgtca
     8341 caggacccgg ctcatgctga cgccggtgtt ggacaagggg gtcgggcgcg ggtgcgcctg
     8401 ctcccggcac ggtgccgctc gcgggcggct gatcacgagg agagtcatgc ctactttgtc
     8461 ggagatcgtc ggcccgggcg cgcacagggc cgatgcgttg cgcctggaga tggtcgtcgc
     8521 cctgcggaag ttggggacgg tgcgttcgga cgccgtggcg aaggcggtgc tgacggtccc
     8581 gcggcacgtg ttcgccccgg agtcgtcgtt ggcggaggtg tacgagcccg aacgggcgct
     8641 ggtgaccaag cggaacgagc acggcctcgc ggtcagctcg gtgtcggcgg cgcgcatcca
     8701 ggcgcagatg ctggagcagg cggacgtgcg gccggggatg cgggtgctgg aggtcgggtc
     8761 gggcggctac aacgcggcgt tgctggccga actcgtgggc ccggagggcg aggtggtgac
     8821 ggtcgacatc gacccgttcg tgaccgagcg cgcgcagaag tacctcgcgg aggccgggta
     8881 cgggcgggtg cgggtggtgc tggcggacgg ctccgagcag gtggagggcg gtccgttcga
     8941 ccggatcgtc gtcaccgtcg gggcgtggga cctgccgccg gcgtggaccg gcgccctggt
     9001 cgagggcggc acgatcaccg tgccgctgcg gatgcgcggg ctgacccgct cgatcacctt
     9061 ccggcgggag ggcgagcggc tggtgagcgt gtccgccgag gtgtgcggct tcgtcaagat
     9121 ccagggcgcg gacgcgcacg acgagttcct ggtgctgccg cgcggcacga aggagatcgg
     9181 gctgcgcttc gacgagctgg agcgcccgga caccagccgt ctgggcggcg cgctggagac
     9241 gccccgcgcg gagtggtgga cccgggtgac ggtcggcaac cgggagccct tcgactccct
     9301 gtacctgtgg ctggcgtcct cgctgcccgg cttcgggctg atgtccgtgg acccggagct
     9361 ggacaccaag atggtcgccc cggcgaaccg gatggcgtgc ccggtgatcg tggagggcgg
     9421 cagcctcgcc tacctcgcgc tgcgcaagat caccgacgaa ccgacgacgt tcgagttcgg
     9481 cgcgcacggc ttcggccccg agggcggacc tctggccgcc ctgatcaaca ccgaggtgcg
     9541 gacgtgggat cgcgagcacc gcggcggcga cggccccgtc ttcaccgcgt acccggcggg
     9601 cacgcccgac gaccggctcc cggacgggct ggtcatcgac aagacccacg tccggctcac
     9661 gatctcctgg ccgtagtccg cggccaggtc ctgcaccacc gactccaagg aggaagcacc
     9721 atgacccagt ccctcaccgg caccgtcgcc gcgggcgact tcgacctcga cgtgaccatc
     9781 gtggagggcg ccgacccggt ggccgcgctg ctgcgctcga ccgacgacgg ctgcggcagc
     9841 acctgtgaag gcagcgcctg cgcctcgggc ggcggcaacg tctgaccgca ctcctctccc
     9901 cgcgtgacct gggcccggcg tgcggccgtc aagccgccgc acgccgggcc ccggcgtttc
     9961 cgaaacctcc tgaaatctcc cggaatcgag gcgaataccc gtgtacgaag ccgtgggacc
    10021 ggccctgctg cgggccgccg cccgtccggc cggagccggg ccgtcctggt ggcccgacct
    10081 ggccgacacc ggcacacacg ccaccgcgaa ctggcgggcc tggctccagc acgtctggtc
    10141 ggacgaggtg ttcgcggcgg ccgtcgaggt cgccgccggc ccgcagctgg ccgcccgagt
    10201 acgcgaggtc gtcttcaact tcgaccacgc accccggcgg cggctgcgcc gcctgaccgc
    10261 ctcggtgatg cagtacgcgc tgcgccagca gcggcccacg cccttcgggc tgttcgccgg
    10321 ggtgaccgcg gtgcccttcg gcgaggccgc cgccgcgccc cgctggggtg catcccgggc
    10381 ggtagcgcgc ccggatgcgc gctggctggc ctcggtggtg cgggagctgg aggaggctgt
    10441 cggggacctg ctgccggtga cggccaacca gctgcgggtg cggcgcgggg accgcatcct
    10501 gctgccggtg acgtgcaacc cgcaggacgg ggaaccggcg gagctgtccg tccgcgccac
    10561 cgacccggtg ctggccgtac tggaggccgc cgacggcccg ctgtcggtga cgctcggcga
    10621 actcgccgac cgcttcccgg ccgccccggc ggacaaggtc cgcgccatgc tcggcgaact
    10681 ggtgcgccaa ggcttcctga tcagcatcct gcggctgccg accaccgcga ccgacccgct
    10741 cggccacctg ctcgccgtcg cccgcaccac cggcctcgac caggttcccg ccgccgccgc
    10801 gcccctggac gaactgcgat ccgtccggga gcagtcggcc cggcacaacg agtccgccga
    10861 cccggtcgag cagcggacgc tgcgcacgcg gctggcccgg cagcaggccg ggcgctcggg
    10921 cgaggtgccg tcgctgatgg tggacctgca cctggacgca gggcccgcgg tgctgccgcg
    10981 gcgggtggcg tcgctgatgg ccggcgcggc cgaggtgctg acccggctgt cgccgttccc
    11041 ggacggccat ccggcgtggg tggactacca cggcaggttc ctggagcggt tcgggcccgg
    11101 cgcggtggtg ccggtggtcg agctggtgaa cccggacacc gggatgggct tccccgcccg
    11161 ctaccggcac tcggtcctgc ccgacgtgcc gccgagggtc cgtcggcgcg acgcccagct
    11221 gatggcgctg gcgcagaagg ccgccgtcga gtgcctggac gaggtcgacc ttgacggccc
    11281 gctgctggag cgcctcgccc cgagcccggt gcccgagggg gtggtgcagc cgcacgccga
    11341 gctgacggtg cggctgtcgg cagacggggc cgtgccgttc accccggtcg tgcaggcggt
    11401 accgcgcggg gcgggcacga ccgcgggccg gttcctgtac ctgctggaga ccgagcgccg
    11461 gcgcgagctg gaggcggcga tcgccgccgc gccgccgctg cgggcgggcg cgctggtggt
    11521 gcaggtctcc gcgccgccgc tgtacgcccg agcggagaac gtctcccggg ccccggcgct
    11581 gctgcccctg ctgacgctgg gggagtaccc gcagatcgga tcggtgctgc ggctggagga
    11641 gttgggggtg tgcgcggacg agcggcggat gtggctggtg cggctcgccg accggcgccc
    11701 ggtggaggtg cgggtcctca acgcggtgga cttccgggcg aacaccgacc cgctggtgcg
    11761 gttcctgtgc gagatcaccg gcgcccacac gccgtggctg accgcgttca actggggcgc
    11821 ggccgggcgg ctgccctacc tgccgcgggt gcgctacggg gaggtggtgc tgtcggcggc
    11881 gcgctggcac ctgcccgccg ccgacctgcc cggcaaggac gccgagtggg agcagtggcg
    11941 ggcggcggcg ggcgagtgga tcgcccggta caacgtcccg gcggcggtgt acctgtcgca
    12001 gagcgacctg cggctgccgc tggacctgag gttgccggag cacctggtga tgctgcgcga
    12061 acacctgctg cgggagccga ccgcgatcct gatcgaggcc cccagggcgg acgacaaccg
    12121 gtggtgcggc cgggcccacg agatcaccgt gcagctgcac tccacccgcg ccccgctgcc
    12181 cgccgcgcac ccgcggcccg ggcggccggc caccgtccgg tccgggcacc tgcccggcgc
    12241 gtccgggtgg ctgtcggccc gcctgttcgg caacccgcgc cgcgccgacg aactcctgtc
    12301 ccgcgtagaa gggttggccg ctgactgggt ggtcccgccg cagtggtggt tcctgcggca
    12361 caccgacccc gaaccgcacc tgcgcctgcg cgtccccgtc tccgccgtcg ccgcgtggtc
    12421 gctggccgcc gagcggatcg gccggtgggc ggagcagatg cgggaggagg gcctgttgac
    12481 acggatggag atcgacacgt acctgccgga ggccggccgg tacgggcgcg gggcggcgct
    12541 gcgggcggca gaggcgttct tcgccgccga ctcccgggcg gtgctggccc aactcgccta
    12601 ccagcgcgcc acctccaccg acccggccac cgtgacggcg gcgagcatgc tcgacctcgc
    12661 caccgcgctg ctcggcgagc aggccggaca cgcctggctg ctggagcggg tgccgcggca
    12721 cagcggcatc gcactaccgc gctctgcgcc tcggttggtc gccgaattcg cggaccggcc
    12781 agagcggttg gcgctcaccg aggagggccg cgccctcgcc ctggtgtggg aggtgcgggc
    12841 caagaagctg gtcgactacc gcagggcgct cggccgggac ggggagctgg agaccgccga
    12901 cgtcctcggc tcgctgctgc acctgcacca cgcccgcgcc gtcggcctcg atgcggccag
    12961 cgagcggatc tgccaccgcc tggcccgcgc cgccgctctc accctcaccg cccgtgctca
    13021 ggaaggacag ccggcatgac cgctgaactg ctcgcaccgc ccacccaagc atccgcccag
    13081 tggggccagt ccctggccaa ggggggcctg gccaccgcgc tgctgcacat cgagcgcgcc
    13141 gccaccggca ggggcgactg ggacaccgcg cacgagtgga tcaccgcgtg cgtgagccag
    13201 cccgtgaact ccttcgccgg ggcctccgtg ttctacggcg cgcccgccgt cgcccacgtc
    13261 cttcacctgg ccacgatgca cggcccgcgc gcctaccacc agccgcgcat gctgctggac
    13321 gccgcggtgg agcacgtggt ggagcagcgc ctggccgccg cccaccgccg catcgatgcc
    13381 gggcagcgcc ccgccttcca cgagttcgac ctgctgggcg ggctgaccgg tctcggcgcg
    13441 cacctgcggg tccgcggccg ccaggagctg ctgcgcgagg tgctggccta cctggtgcgg
    13501 ctgaccgagc cggtgcaggg gcgctccggc tggtggacgc acctcgcacc gagcggtgag
    13561 caggacgagc ggtacccggg cgggcacggc aacttcggca tcgcgcacgg catccccggc
    13621 ccgctcgccc tgctggccct cgcccacctc gacggcaccc gcgtgcccgg ccacctggag
    13681 gcgatcgagc ggattctcga ctggctggac gcctggcagc agaacggcgc cgcccgcgcc
    13741 tggtggcccg aggcgatcac cgccgcagag gccgaccagg gccgcgcccg gcagtcgaag
    13801 ccgctgcgcc cgtcctggtg ctacggcacc cccggtgtcg ccaccgccct gcaccacgcc
    13861 gcccgcgcca ccggcgaccc cgcgcgcgcc cgcaccgccg aagccgcctt cctcgacgcc
    13921 ctcgaagacc ccgaccaggt gcacagcctc accgacgaga cggtctgcca cggcacggcc
    13981 ggggtccgcc tggccgcccg gcgctttgcc gaacgcaccg accacaccac cgcggtgcgc
    14041 atcctcgccg ccgccagcac cctgcccgcc ccggtccccg ccgcgaccgg acagggcctg
    14101 ctcgaaggca ccgccggtat ctccctcgcc cgctgctccc tggccgccga gacgcccggc
    14161 accggctggg acgccctgct gctgctcgtc tgacccgaac cgaagaagga gaactctggt
    14221 gctcgccacc ggcgaccgcg cctggacgca ggtccacctg cacctggcca ccgacacccc
    14281 cgaggagcac gccgtccggc tcctcggccc cgccctgata tccctggagg accaggggct
    14341 gatcgactgc tggcacttcc tgcgcaaggg cgaccgctgg cggctgcgct accgcgagag
    14401 cgcctccggc atcctggggg ccgccaccac cgcgttcgcg gtcaacgagg ccctggacat
    14461 gtgccgcgaa gcgggcatga tcagcgactg gaccccggcc ctctacgagc cggagaccta
    14521 cgccttcggc ggggccgccg cgctgcccgc cgcccaccgc ctcttccacc aggacagccg
    14581 ccacgccctc atctacctcg ccgccgtcca ccgcggcgaa ctgcccgacc agcgtgccga
    14641 gctgtggctg ctgctcggca cggccgcgat gcgcggggcc ggactcgact ggtacgagat
    14701 cggcgacacc tgggcgcagg tcgccgagaa ccggccccgg ctgtccgtcc cggatcggcg
    14761 cctggtcgac gccgcgcgca ccctgctccg ggccgacacc gcccccggct ccgcgctcct
    14821 ggagggccgc ctcgcccacg ccgcaggctg gttcggcgcg ttcgccgtcc acggcctgac
    14881 cctgcgggcg ctggccgacg aggggcagct gtggcggggg cagcgtgccg tcctcgccca
    14941 ccaccagctg ttcaccgcca accgcctcgg cctgccccac cagcagcagg ccgccctcgc
    15001 ctcggccgcc gccggcgctg tcctggacct cgtcgacgcc gacgaggcgg tactgcggtg
    15061 accacccaac gcactgccca gcccaccggc ccgctcggcg acgccctcgc ccgcctcccg
    15121 ctcgtccccc gcaggcacgc cctcgccacc ccgctggagc agcgggtcca aaggctcacc
    15181 gacctagccc ggcaagccgc cgacaccgag aacccgacca ccgccaccag cgtccacaac
    15241 ctcgccgcgc tcctcgcctc cgaccgcggc ttacccggcc tggctcgcgt gctgtgcctc
    15301 aaccacgccg gcttctacct cgcccaccgg ccgctgaccg ccgacctggc ccgcctggcc
    15361 ctcgaacccc tcgtcaacct cgcccacctc gaactccggg cgggcaacgg catgccggca
    15421 ctcgccatcc tggacgagct gacgcgcgcg gtcgccgaca acgacgacgc caccctcggc
    15481 ggcctggtcg tcccgctcgc cggcctcact gccagcagcg tcgaccgcgg caacgtccac
    15541 gagtggctga gcgacatccg ggtcttcggc ggagcccgcg ccctggtccg tgccgggcgc
    15601 tggtccgacg cccgcctgca cctccagcag tccaccgccc ccggcgaccg cctcttcgag
    15661 gcccgccaag tcgccgctgt cgccatggcc atcgaaggcc gcaccgccct cgcccgcacc
    15721 ctggcctgca acacccccgc tgaggaaccg tgggagcacg ccatcgccgc cgccctgacc
    15781 gccgcgtgca cgctgctcga cggtgccccg gccgccgagc agaccgagac cctgctccac
    15841 gcccactccg ccgtcgcccc gcaggacggc agtgcggtgt tcgacacccg gctcgccctg
    15901 accgtcgccg acctcgccac cgccgcaggc caactccccg acgccgcccg cgtctacctc
    15961 accgcagtcg gccggacgat cgccgcaccc gagggctaca gcgcccgcga cctcgcccgc
    16021 caccccctcg ccgacggcct ccctccccaa cagcgccgcc aactggcagc catcgccgcc
    16081 gactccggcg tcggcggccc ggccaccctc accaccgacc acgacgaccg gatcaccgcc
    16141 gccctcgccc tggccgccgc cgtcatcagg agtgcgggga cgggccggtg aaccgcgctg
    16201 ccgacgccga ccgagtcgaa cggctggcgc tgttcggcgc gctgctgtcc gccttcggcg
    16261 agatccaccc ggcctgtgac cagtgggccc aggactcgac cacggcgtgg tgcaagcggc
    16321 tgagcggcaa gcacctcgtc taccgggacg gcgtgcgcgt tggcgacgag agcgacgacc
    16381 gcggcggcga gccgacgatg acggccgacg cccgggcccg ccgcgcggtc gccgtgcacg
    16441 tcgccaccta caccgcgatc cagagcggtg cggccctcgc cctcacccgg gcgttcggct
    16501 accgcgtccc ggcctccgcg ctcctggccg gcgcggccat caacgccgtc acccacgcgg
    16561 ccatcgaccg cggcccgctg ctcctgtggc tcgcggacag gacccgccta cgtggctaca
    16621 tcgagcactg ccaagccgta cgcctcgacg ccgacggtga ggcacacgcc gaggttaacg
    16681 ggcccggaac cgcctggttc gaactcgacg ccgccctgca ccgggccgtc ggcgtcaccg
    16741 ccgcggccgt cacgacctgg ctcgccaccc gccggacgta ccgcaggtga accaccgcct
    16801 cccgcaggtc accgtctgga gcatgcagag gtggtgggag gccgtagacg ccgaggtcga
    16861 aatcatccgc cactgccccg cccggtgccg ccccgccccg ggcggggcgg tacccgctat
    16921 ccacccgaag gaacttcccc tcatgtccgc caccggcacc agcacagccg caccggcccg
    16981 cagcacccac cagcaccccg cccgggccgc tcggaccgct ctgcaccacg ccgccgcgct
    17041 cgccggactc gacccggcag gcgcccaact cctccatcag ggaaggaact tcgtcttccg
    17101 cctgcgtggt ggagtgatcg ccaaggttca ccaccgccgc cggtacgccg atgtgcagcg
    17161 agacgcccgg gcggctcaag ccctgctcgc cgcgggcata cccaccgccg cccccttcgg
    17221 cgacggccgc cccatcaccg ctggcggcct ggtggtcagc ttcaccgagg acctgggcac
    17281 cacggagccc acctggggcc agctcgccga ggccgccgcc tgcctgcacc acatcccgcc
    17341 cctggccggc ctcggcctcc cgctcatcga caagatcacc agcgcggccc gccgcatcac
    17401 cctgctcccg tcgagcgtga tctccgaaac cgaacgcgct cgccttctcg ccctcctcac
    17461 ccgcaccgcc gacgcctaca ccagcatcac ctggcccgcc ccgcgcaccg tccacggcga
    17521 cctcaacccc ggcaacggcg ccctcctcgc cagcggcggc accgcgctcc tcgacctgga
    17581 aaccctctcg atcgggcacc ccggcttcga ccaggccgca gccgccttcg ctcgcgatgc
    17641 cttcggcctc gacccgtccg tccacgagga ctgggtggac aactacgggt acgacatcac
    17701 caccgccgcc ggcggactcc cgtaccggac gatctcgatg ctcctcggca tcagcgccta
    17761 cctcttctac gcggagctgg gcacacaggg cagacccgag gtcctgcccc aggcccgcca
    17821 ccgcctcgac accctcctcg ccaacaggca gttcccgtgg gactgggctc ctgccaatcc
    17881 cgttcgggca gcagcggcag ccggtaccgc aggctgacag ctgctgtggg ttcccggaga
    17941 gctgccagta ccggccgaag ctggtagcga cacaagccca gctgccgcct accgtcctcc
    18001 ccgccgccaa gccgcgcgag gaggacacgg tggagctgat cgtcacggcc gaggaggtcg
    18061 cccgccgcct cggcctgtcc gtcccgctga ccgacgaggt tcggcagcgc gtcgagaccg
    18121 cggttgagga cgcgcaggag accctcgtcg cgcacctcgg caggccgctc ctgcctgtcc
    18181 agtacaccga gagcggcatc cgggccggta ccagcggatg gaacctcagc cacgcccccg
    18241 tcatcacggt catctccgcc gtgcccgacg cgacctcgct gcccaccccc tcgttcggga
    18301 cgccgaccta caccgtcacc tacatcgcgg ggatcgacgc cagcaccgac ccggagaccg
    18361 cgccgctgcg cctgtgggtc cgggcgacgg cctgccacca cccgctgctc gccgacgcgc
    18421 cgctccggca gcgccgcatc gcctccgcct cggtggaggg ccagtcggtc acctacgaca
    18481 ccgcggtcga gccgccggtg ctcctcgccc cgcctgacct gacgaccacg gaccgatggc
    18541 ggctgcgcgg ccgccgggtc taccaggacc cggtccggcc gaacccgccc ggcctgaccg
    18601 tcccgggcgg gccgtgatgg gcgtgctgct ggccgaccgt cagctcggcg tgcgcacccg
    18661 gggcgctccc ggcctcgatg cccacggagc ggaggtgacc gggccgcccg gcccgctgcg
    18721 gggcccgtgg cccggccgcg ccctgcccca gccggacggc acctggcacc tggcgctcga
    18781 cccgcaggcc ggcaccctgc tggtcgggga cctggtggtg gagccggcca gcggcaagga
    18841 gtggacggtc accgccgccg acgacctggt gcacgccgcc gacccggccc tggcctacgt
    18901 ccgggtgacc gcccgatccc gccaggctgg tggaacccga gcagaaggac acccctgatg
    18961 gcccgccttg agctgcccgc cgacatcgct gaacggctcg ccccgctgct gcgccgccac
    19021 accgaacgcc tcgccgagga agtcgcggag gaagcccgca ggcgcgcgcc cgcggcgaag
    19081 acctggcaca cccaggagga cggcaacgcc cggcccagcc accaggccgc cgacgggcag
    19141 accgtgcccg ccccgctgcc gttctctgtc ggcaacacga cgctcgaccg gccccgcgac
    19201 ccggacggcc cggtcgagga gaccgccggg tgccgctgca ccgtcaccga ggacccggaa
    19261 gccgtcgccg ccgccatcac ggcgggcaag gccgccacct ccggcacgcg cgtacgcgcc
    19321 accgtcacct gcgactaccc gcgggccgcc gaggccgagt acgcacacgg cgacggcagc
    19381 cacttcatgg gcgccgccgc ctccgaggtc gccaaccggc accggtgaac ccgccgcccc
    19441 cgccaccggg gcggccggac cgctctccgg cgggacggta gccgccacgc ctgctttcct
    19501 tcgcccggtc accccaaccg ctcgaaggag tcgacatggc cgccgcaccc ggcaccgtcc
    19561 gcatcaccct cgcccaccac ttcgaccggg acggcgcgca gctgctgccc ggcgacgaga
    19621 tcgacgtgcc gacccacgag gcccgcaagc tcatcaccgc cgggtacgtc gccggggtgg
    19681 accccaacga cccggaagcc gtggcgaagg ccctcgcccc ggccatcgag cgcaagccgt
    19741 cgatggccaa gccgccggcg aacaaggcgg cgggcccggc gagtgagtga cctggcctcc
    19801 ctggacccgg aggagctggc cgtcacctgg ctctccggcc acgccgagct gaccggggcc
    19861 ctcggcggcc ccggccgggt cggcgcccgc aacaccccgc cctacccgcg catccgcatc
    19921 acccaggtac cgggcggctc cgcccccggg tggcgctgga ccgccacctt ccacctccaa
    19981 gtcgaagcgc tcggggacct ggaccgctcc acgccccggc cggagctgcg gaaggcattc
    20041 acggtggccg tgaaggcgct gcacgaactg gccgggcagc aggccgtgcc ggggcggccg
    20101 gtggtgaccg cggtgcgggc gctgtcggcc ggcgggtggc tgccggagcc gaccggccag
    20161 ggccgctacc tggtcatcgt ggccgtcacc gcgcatcccc cgacccggtg accggccggg
    20221 ttgtgcgagt tctgcgacag ccccacgcgc gccgcccggg gcgacgctac tgacctgccc
    20281 ggcctacggt ccggtccgtc gttgacggcc cgcatcaagg aggaccggcc gtgcccgcag
    20341 agagcatgtt cgtcgcgcag atggcccgtc tgtacctggc ggtgccgggt acggtcgcgc
    20401 cggcggaccc gttggtggcg ctgcccaccg ggtggaagga ggccgggctg ttcaagcccg
    20461 gctcgctgga gtggaacacc gacccgaagt tcgagaagct ccgctcgcac cagctgcggt
    20521 acgcggcgcg caccatccag accgaggacg cggcgacggt caaggtggag ctgcaggagt
    20581 ggaacgccaa caacatctgc gcggtctacg gcggcggcga ggtcaccacg gtcacccagg
    20641 actcgaagac cttctaccgg tacaccccgc cgaaggtcgg cgggcgcaag cagttcgccg
    20701 cggtggtgga gctgatcgac ggctccaagc actaccgccg gatcgtgccg ttgtgcgagc
    20761 aggtcgcggc ggtgaaccag aagttcccgg acgacgccga gtccacgctg cccctggaac
    20821 tcgccatcat cggcggcgag tccaccgacc cgtggtacga cctgaccgac gaccctggct
    20881 tcgccccggc ggcgtgaaac ccttcctgac cagcacagtt gaggctgtgc ccataggtct
    20941 gaggtccgca tagtgtggat cacgccggtc ggcccccgcc gcccccttcc ccggggccga
    21001 ccgcacccgc gatgccccgt ccgatcccct ccggacgggg catcgctgca ttcgcgcggg
    21061 gatggccgtg cggcgcagtc ggctggggcg ccccccgggt agcacttgtg ggtaatacct
    21121 taagagtcac actttgctgt cgtaccttac ggtgctactc ttggcctcat ggcgaaggta
    21181 tcggtctcca tcccggacga gctcctcgag cgggcgcagg ccctccacca gcaggacaac
    21241 gtgagccagc tcgtacagaa ggggctggcc ctcctcgctc ccgagaagaa gcagccctac
    21301 cgcccggagt gggcgaaggc cggccttgcc gaggtggccg accgcctccg ggccgcagcc
    21361 cgggaagact acgaagaggg ataccgcgcg ggcttcgagc tcgccaaggt cgccccctgg
    21421 gattggctgg tctggctcgc ctcgtggagg tttgacctca agcgggtcct gagcatccac
    21481 cggaaagctc ggtacgacaa cgattactcc gcgttccaag agattgcggc agctcagcgg
    21541 tcggcacccg gctggtccgg cgattggtat cagagcctcg ctgaggcgtt ccccgctgag
    21601 ttcgctgagc cggggtcgga ggactgcctc gaacgcagcg gccagtttct ggccggtgcc
    21661 atgcaggcgc tccgggatgt ctgggattac gccaaccagc ccatcggcca atgaagttcg
    21721 tgccgcaaag tccctgctag cacttcgcgg ctgagatccc cgcccacccc tcgcagtgct
    21781 tcctacggcg aacagcgagg ggcggcggtt gcagtaccca tctgaatcga gtccgaaagg
    21841 cacctagtgg gcattatcgc gcgtcgctcc caggagagcc acgcccttcc ctcagagtcc
    21901 atcctccgcg gccggatcat ccgggccatc cgtgaccggg ccgcaaccga tggacttccc
    21961 gcggtccttc tcggcgtcct cgtgtatggg accgtccacg gcttgtcggc ggggcaggtc
    22021 atgttgctga ccgccgaggt ctccctgttc gtgatcgccg agcgctggtg gagggcccgg
    22081 cgcgcctgac cgccgtgccc agcaccacca cctaacccgt agaaggggcc gccggtacgc
    22141 cgacggcccc ttccgcgttg gtgggtggcg gccccccacc cgcatcgtgc tgcccctgca
    22201 ctcggtgctg ggcgcgacgc taaccggcgt tgactcctac ggtctgcggc gttccgttgc
    22261 cgacagaccg aggagccgac atggccggga tcgacctgga cgccgcgcgc cgccgccggc
    22321 tggccgccgc tgccgagaag gcccaggcgg cgaaggccga gtacaccgtc ggcgaggagc
    22381 cggtcatctt cggcggcgtc accgtggcgg tgctcccggc cgaactgccg ctcgcggtgt
    22441 gggagccgct gatcggcatc ccgtacctgc cgctgttgct gcgctcgctg gtggaggccg
    22501 cgcagtcgca gggcgagcag cagacccagg ccgcgggcct gatcgtggac gtgctcggct
    22561 ccgagccgac cctgccgtcc gacctgctca ccgcggccgc cgatatgggc cgccgcctgc
    22621 tcggcgagga cggcttcacc cggctgatgg aacagcgccc cagccacacg gacgtcttcg
    22681 agctggtgcg cgccctgtcg gcgaagtact tctcgggcgg tgccggcctg ggggaactca
    22741 tggggccgtc cggctcgcct tcgagcggtg ggacgacctc gaagccgact tccagcggta
    22801 ctaccggatc gacgcccgcg gtgcctggcg gcgtcccggt gacgctggat tcctcggcac
    22861 ccgccgcctc ctgacgctga tgcgggggtt gcccgccgac gcgctgctgc gccgcccggc
    22921 cgccgacgcc ggcaccgacc ggtgggggct gacagaggag ctgctggcgc agctggtcga
    22981 gatggtgtcg gtgttcgccg ccgaccgccg tctgctcaag ccggtcgagc tgccgcgccc
    23041 cgcccacctg aaggccgccg cccgcgagcg cggcggcgac gcgcagggca tggcccgcgc
    23101 ggtcggcgtg ctgcgccgca gcgggagggc ggtccgccgt ggctgacgag atcgactccg
    23161 gccgcctcgt tgtcgaggtc gtcgccgact cgggcggctt cgggacggac gcgaaggccc
    23221 gcgtcgatgc ggccacccgc aacctgcggg cccgcatccg cttggagccg gacgccgccg
    23281 ggctgcgcga gcgcgtcgaa gccgccgcgg gctccgtccg ggcccgcatc aaggtcgcgg
    23341 tcgaggccga cacctccggc ctgcgccagc gggtccagac cgccgtcaac gcggtcaagg
    23401 cccgtgtgca ggtcgccgcc gacttcgacg ccgacggact caacgccaag atccgggagg
    23461 agacccgagg cgttgcgtac ctgcggttcc tggcgctgct ggacgccgat ggcgtcaagg
    23521 agcgagtccg ggcgatcgcc gagtccgctt ccgcccgcgt ccgcctcggc gtcgatgtcg
    23581 atgtggcgag cttgcgtgcc caggtccggg acgcccttgt cggcctgcgg gtcaaggtca
    23641 aggtcgagct ggacacggcc gccgcgacca cccggctggt cgcgttccgt acggccgcgt
    23701 cccggccggt ggacgtcccc ctcaacgccc gcggctccgc tgccggggcg gcgggggagg
    23761 ccggcggcgg gctgctgcag gcggcggagg gcctgggctc cacgatcgcc gggctggccc
    23821 ggctgcccgc gatggcctcc ggcgccctgg cgctcggaca ggccctcacc caggtcgccg
    23881 gtgggctgtt cgccctcggg tcggcagccg cgcccgcggt cgggctgatc ggcgcgctgc
    23941 cgggcgcgat gagcgccgcc gcccagggcg cgggcacgat cctggcggcg ttctccggga
    24001 tcggtgccgc cgtcaaggcc ctcggccagg cggacaccga atccgccggg gtgtcgtcgg
    24061 ccgccgggca ggcccggcag gccgccgccg accgggtggc agacgcccag cgccgccttg
    24121 tcaccgcgca gcgcgacagc gacgagcagg cgctgcgcgg ggccgagcag gtcgcgcagg
    24181 cccgccgccg cctggccgac gtcgagcagc aggccgccgc gtcggtcgcc gccgccgacc
    24241 ggcaactggc gtcggccgaa ctcggggttg cccgcgcgca ccaggccgcc gcgcaggcgc
    24301 aggaagcgct caacggtgcc cggcaggacg cccagcgcac cctggaggac ctgaaccggg
    24361 acgcggcccg ggggccgctg gaggagcaga aggcgctgct ggcgctggag caggcccgct
    24421 cccggctcaa ccaggtcaac gtcagcccgt tctcttcgga gacggaccgg cgggaagcgc
    24481 agatctccta ccaggaggcg gtcaaccagc tcgaagacgt ccgggtccgc aacgcccggc
    24541 tcgcccagga cgtccagaag gccaacgagc agggcgtcga gggcagcgac caggtcgtct
    24601 ccgcgaagga gcaactggcc cgcgcgcagg agtccgagca ggacgcggtg cgcggcgtcc
    24661 aggacgccga ggagcaggcc gcccgcgccc gggtccaggc ggtgcgcgac gtccaggacg
    24721 cgcacaccga gctggaccgc acggtccgcg aagctggcct ccagcagaaa cgttccgccg
    24781 agcaagtagc cgacgcgcag cgggacattg cccgcgcgct gcgagaccag aaccaggcgc
    24841 tcgcctccac cagcagcgcc gccagcgccg ccgagaaggc cctcaacgcg ctctccccgg
    24901 ccgggcagcg cttcgcccgg ttcatctccg gcacggtgca gcccgcgctg cgtgggctgc
    24961 gggacaccgc gcaggaggcg ctgctgcccc cgctggagaa ggggatcaac cggggcctgt
    25021 ccctgctgcc gatcttcgac tcggcgatcc ggcagaccgg g
//
