LOCUS       NZ_CP054919            21002 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Kitasatospora sp. NA04385 chromosome, complete genome.
ACCESSION   NZ_CP054919
VERSION     NZ_CP054919.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora sp. NA04385
  ORGANISM  Kitasatospora sp. NA04385
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Kitasatospora.
REFERENCE   1  (bases 1 to 8400742)
  AUTHORS   Zhang,B., Shi,J. and Ge,H.
  TITLE     Genome mining for natural products
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8400742)
  AUTHORS   Zhang,B., Shi,J. and Ge,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2020) Institute of Functional Biomolecules, State
            Key Laboratory of Pharmaceutical Biotechnology, Nanjing University,
            No.163 Xianlin Avenue, Nanjing, Jiangsu 210046, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. v2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013364235.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 08:11:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,532
            CDSs (total)                      :: 7,423
            Genes (coding)                    :: 7,206
            CDSs (with protein)               :: 7,206
            Genes (RNA)                       :: 109
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 218
            CDSs (without protein)            :: 217
            Pseudo Genes (ambiguous residues) :: 0 of 218
            Pseudo Genes (frameshifted)       :: 81 of 218
            Pseudo Genes (incomplete)         :: 153 of 218
            Pseudo Genes (internal stop)      :: 9 of 218
            Pseudo Genes (multiple problems)  :: 25 of 218
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:10:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3339529
            Orig. end                         :: 3360531
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054919.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21002
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="13"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21002
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21002
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11002](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11002)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            197..832
                     /locus_tag="HUT16_RS14720"
     CDS             197..832
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024248.4"
                     /locus_tag="HUT16_RS14720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_217712059.1"
                     /transl_table=11
                     /translation="MADRTKEREVTDVATLKALADPLRLAVLGALMKHDPEPRSVKEVA
                     AELDEAPTKLYRHVKQLEQVGLVYVAETRLVSGIVESRYRSAQQSLRLSPQVYAEGDEP
                     PPALGAILAAMDLVRSDFRRHFLAGRIDLTPAAQGNPQPGKFAHATFRLSPERLRRLRT
                     RLDEALDEVFAEGDSTDPDAVEVALFALLYAVRPPQAEPGQERAPERD"
     gene            complement(829..1887)
                     /gene="disA"
                     /locus_tag="HUT16_RS14725"
                     /old_locus_tag="HUT16_14720"
     CDS             complement(829..1887)
                     /EC_number="2.7.7.85"
                     /codon_start=1
                     /gene="disA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048797.1"
                     /locus_tag="HUT16_RS14725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14720"
                     /product="DNA integrity scanning diadenylate cyclase DisA"
                     /protein_id="WP_176192681.1"
                     /transl_table=11
                     /translation="MRASLSAIAPGTALRDGLERVLRANTGGLIVLGFDKSVDALCTGG
                     FVLDVEFTATRLRELCKLDGAVIMDKDLTKILRAGVHLMPDANIPTDETGTRHRTAERV
                     NRQTGYPVVAVSHSMRLIAIYVNGARRVLEDSTTVLSRANQALATLERYKLRLDEVAGT
                     LSALEIEDLVTVRDVSAVVQRLEMVRLIAGEIAGYVLELGTDGRLLSLQLDELIAGVEP
                     ERELVVRDYFPDRAAKKGRTVTEVLSDLEALTHAELLDLQTVAKALGYTGTPESLDSAV
                     SPRGYRLLAKVPRLPNTVIERLVDHFGGLQKLLAASIDDLQTVEGVGETRARSVREGLS
                     RLAESSILERYV"
     gene            complement(2057..3589)
                     /gene="radA"
                     /locus_tag="HUT16_RS14730"
                     /old_locus_tag="HUT16_14725"
     CDS             complement(2057..3589)
                     /GO_function="GO:0003684 - damaged DNA binding [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="radA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136539.1"
                     /locus_tag="HUT16_RS14730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14725"
                     /product="DNA repair protein RadA"
                     /protein_id="WP_176188632.1"
                     /transl_table=11
                     /translation="MAARTKTTAKPRPSYRCTECGAQLLKWVGRCTECNAWGTVEEYGA
                     VPIRTTAAGPVSAPAKPIAQVDGQVATARTTGVPELDRVLGGGLVPGAVVLLAGEPGVG
                     KSTLLLDVAAKAASDRHRTLYVTGEESAGQVRLRADRINALSEHLYLAAEQDLGAVLGH
                     IDAVNPGLLVLDSVQTIASAELDGAPGGPAQVREVAGALIRASKERGMATLLVGHVTKD
                     GQIAGPRLLEHLVDVVLSFEGDRHARLRLIRGVKNRYGATDEVGCFELHDEGIVGLADP
                     SGLFLTRRDKPVPGTCLTVTLEGKRPLVAEVQALMVDSQIPSPRRTTSGLESPRIAMIL
                     AVVERHGGVKLGKQDIYTATVGGVKLTEPSADLAIALAVASSSTDTPLPNNLVAIGEVG
                     LAGEVRRVTGVQRRLAEAHRLGFTHALVPPDPGKVPAGMTVVEVSDIGEALRAIPGRRP
                     RSKARQDAAPPVRPAADPAAQALARARAQAPVPAFPEELMAGWEPVDSDELA"
     misc_feature    complement(3634..3647)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.7"
                     /tool="antismash"
     gene            3742..4644
                     /locus_tag="HUT16_RS14735"
                     /old_locus_tag="HUT16_14730"
     CDS             3742..4644
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS14735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_14730"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_176188633.1"
                     /transl_table=11
                     /translation="MTTGQPHPVGPSPVLRAYGACVDGLFTYCLSVLCEHEAATAAVLE
                     VRDLAQRHGDRIDDPALLRAWLYALARHRCLARLDGEAEQDGAPPPGSRGPSGPGAVRE
                     RRRELASLAWPEAAGTDPEQREALELAVRHRLDGAEVAAVLGLSTEAAAALLDAAGAEV
                     GRTRTALLVLGVGSCPELAQLGGVGAESWRGWVLGPALRRELVVHLVECPTCRGTAERV
                     AGQLGHGLAGLPGLPLLAAPGPLRPAAAPPSGGTAFLAGAAAGRRIAQGPVPPRFDQRG
                     FPGTGSPRRRAVRRCGSGW"
     gene            4638..5510
                     /locus_tag="HUT16_RS14740"
                     /old_locus_tag="HUT16_14735"
     CDS             4638..5510
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040218.3"
                     /locus_tag="HUT16_RS14740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14735"
                     /product="hypothetical protein"
                     /protein_id="WP_176188634.1"
                     /transl_table=11
                     /translation="MVTTGVLAAVLAAPVVALWSAHRGGGEDHASAVSSVRVDPTAGPG
                     QRVPVPEPTPVAVLPPVARVATMELAGVVTAETSLPSVQGAAVPVPSHGAAPLSSPALT
                     AEPGPPPSATASRLTVQAGAYGNRTVLTLTNSGDGPLSWHAVLDVDWLRLSRDSGTLEP
                     GQRITVTVTVDEARAPRSRWTAHLALPPSSAVVTLEGGTDHRGVPTPDGPSPDPSPTPT
                     PSASASASASASDPAPASPSPSAPSSPPASSSPPPASPSPSPSAPSGSPDSSGSPGSTG
                     PSAPVSPPP"
     gene            complement(5982..7313)
                     /locus_tag="HUT16_RS14745"
                     /old_locus_tag="HUT16_14740"
     CDS             complement(5982..7313)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136543.1"
                     /locus_tag="HUT16_RS14745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14740"
                     /product="DUF1254 domain-containing protein"
                     /protein_id="WP_176188635.1"
                     /transl_table=11
                     /translation="MADATPEMLAAEAFVYGSPLVANLTTVDTIHRRGIGSIPAVEWNS
                     FGHADRLADQHAEFVSVNNDTVYSVAPLDLSAGPLLLHVPDTGGAYDVLQFIDAWTNNF
                     AYAGRRSSGTAEQSWLVAPPGWRGTAPEGVPVITAPTAVAVLAVRNYCAGPDDLPRVRD
                     LQRQLTLTPLADGGTPAGLPEPDAGVPAELLFLERLRRWAAAFPPAADDVAFQQRFAPI
                     GLLDQGRSPYLDGPAEWAAALAKGLAAGRERVEAATVGAGDPTGEWTANLHLFDYNLDF
                     LGPGTRDEPQWRIADRRAAYLTRAVAARAGLWGNHAYEAAYATTYNDADGVPLSGAHAY
                     TLRFEQTPPVGAFWSVTMYGTPDYLLVGNEIDRYSIGDRTPGLVHGEDGSLTLYVQHRR
                     PTDPEELANWLPAPEGGFRPMVRMYQPQDAVLDGSYRLPAIRLR"
     gene            complement(7341..8639)
                     /locus_tag="HUT16_RS14750"
                     /old_locus_tag="HUT16_14745"
     CDS             complement(7341..8639)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136544.1"
                     /locus_tag="HUT16_RS14750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14745"
                     /product="DUF1254 domain-containing protein"
                     /protein_id="WP_254897809.1"
                     /transl_table=11
                     /translation="MGNPVGADPAAVRRTAAQAWTWGYPMLENYRMLYPQAIDDADPRY
                     VGGFGVFRHHPQPAAAAGTDAVTPDRDTAHSWAWLDLRAEPWVLEKPATGRYHVLPVHD
                     LDTAYVGFVGSRTTGDGAGRYLIAGPGHRANPPEGFDGVLRADGNLVGIVGRTASAGEG
                     DAPEVERVQAGYLLKPLSEHLGTPRPVAGEPVWPVWRGEEVLGTLEFFSLLDFLLGFFP
                     ALPADADLRGRLTELGVGSGDFEPAALPAEVREAMLAGIADARAELARAVEGATAGAVR
                     SGTREQLGTDHLNRALGARTGLYGLPAEEVWSGDGRPWTAGGLEPAVLRFAPGRLPPAR
                     FFWSASVHRLPERLPADDGTDRCAIGDRTPGLVHGEDGSLTLYVQHRRPTDPAEAANWL
                     PAPEGPYSVAVRAYGPGPELLDGSWRLPDLTPR"
     gene            8839..9840
                     /locus_tag="HUT16_RS14755"
                     /old_locus_tag="HUT16_14750"
     CDS             8839..9840
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959104.1"
                     /locus_tag="HUT16_RS14755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14750"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_176188637.1"
                     /transl_table=11
                     /translation="MDILLLGGSKFLGLAYATEALARGHRVTTFNRGVSRTDPPGVEAV
                     HGDRANPDDLRRLVEGRHWDAVVDTSGQQPHDVATAARLLSGRAGHYGFVSSVHAFADW
                     PARPVDADSPTLDCPGDLPPDQPFANALKAGCERALRDHFDGPAAILNCGLLIGPHEPI
                     GRLPWWLDRIARGGRVLAPGTPDRPLSLIDARDFAAFGLDLAQRRAAGRYLTTAPIRST
                     TTGEFLDACRTATGSDAELVWTPDADLLAAGVSPWVELPLWAPAADGWHGTWRADPATA
                     LAAGLRVRPLLDTVTDTWAWLEAGGRAEVAYRQLDTPLGIDPAKEREILAGA"
     gene            complement(10001..11002)
                     /locus_tag="HUT16_RS14760"
                     /old_locus_tag="HUT16_14755"
     CDS             complement(10001..11002)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019992369.1"
                     /locus_tag="HUT16_RS14760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14755"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_176192682.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.7e-62, bitscore:
                     208.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALLSRARTTVDPALRAAVDTLPDSMRLVAGYHLGWLEADGAPSA
                     VGAGKSIRPALVLAATTAVGGRPQDAVRAAAAVELVHNFTLLHDDVLDRDHTRRHRPTA
                     WRVFGTTGAILAGDAMHSLALRVLAEDPHPAASASVRRLADCVVELCAGQQADCSFEQR
                     TDVTLAECLAMAEGKTGALLGCACALGALYAGADAETADAMDAFGREIGLAFQLIDDLI
                     GIWGDPAVTGKPVGADLAARKKSLPVVHALSSGTPAGAELAALYATGRPLSPAELAAAA
                     DAVDRAGGRNWAQTESCDRMAAAIAHLAAAVPDPARADDLLALAELVTRRTY"
     gene            complement(11201..12607)
                     /locus_tag="HUT16_RS14765"
                     /old_locus_tag="HUT16_14760"
     CDS             complement(11201..12607)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136547.1"
                     /locus_tag="HUT16_RS14765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14760"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_176188638.1"
                     /transl_table=11
                     /translation="MTTETTAGIPQTRPRSSLSVAAAKNLASTTKSAPQMQEISNRWLL
                     RALPWVEVSGGTYRVNRRLSYAVGRGRVGFVRTGREVAVVPPTLREVPVLRGFEDDALL
                     AELAGRFVQRDFAAGEVLIEQGREIDEVYLVAHGKVDKVGTGKYGDPTVLGTFADGDHI
                     GDEALTVADRRWPYSVKAATAGTVMVLAWPAFQELADRSEALRDQILAFIADSQLPQTH
                     KGEAAIGMSAGHEGEPVLPTAFVDYELAPREYELSVAQTVLRVHSRVADLYNKPMDQTE
                     HQLKLTVEALRERQEHELVNNPEFGLLANAEYGQRIQTHSGPPTPDDLDELLCRRRSTK
                     FYLAHPKAIAAFGRECNSRGLYPEAIRFEGRTVPSWRGVPILTCNKIPVVDGTTSILAM
                     RVGEDNQGVIGLRPGALPDEVEPGLNVRFMGIDEKAVISYLVSAYYSAAILVPDAIGVL
                     ENVNVAHWQH"
     gene            12932..14029
                     /locus_tag="HUT16_RS14770"
                     /old_locus_tag="HUT16_14765"
     CDS             12932..14029
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136548.1"
                     /locus_tag="HUT16_RS14770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14765"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_176188639.1"
                     /transl_table=11
                     /translation="MTAPVRVWLNRTYAENVFFIDLLRAAPRPVHVLATHVDPDSPVIA
                     AADLGALEPDGLTAEAYVEFALEFCARHDVDVFLPRLHQLAISLRRRDFEALGTALVCP
                     PASAISLFASKVDGYRALDAVGLPTPLWRQAGTASELLAAVEEIEATGSAACLKPASGA
                     GGEGFRVLTREPFNLGRLAGYVDARVQLDQVLGALERSAAPAELLVMPYLDGPEVSVDC
                     LAEQDGRVLAAVGRTKQGRRRGFTVDPAYLEPARRLVAEFGVGHLSNVQFRHERGTGRP
                     VVLDVNTRPSGGLHQLRMCGLNLPAAALELALGARPSLPAADELTLGEYTLVSAIQAVL
                     PRQSAAPALERLDGAERRPAATVAV"
     misc_feature    12974..12985
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 14.77"
                     /tool="antismash"
     misc_feature    12975..12989
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.86"
                     /tool="antismash"
     gene            complement(14043..14576)
                     /locus_tag="HUT16_RS14775"
                     /old_locus_tag="HUT16_14770"
     CDS             complement(14043..14576)
                     /EC_number="2.1.1.63"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003908 -
                     methylated-DNA-[protein]-cysteine S-methyltransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136549.1"
                     /locus_tag="HUT16_RS14775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14770"
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="WP_176188640.1"
                     /transl_table=11
                     /translation="MQLSWVTVPTPLPSGPMRFAVTDRGVAAASYLCDTPVPECTDERR
                     ADLVRARVGEYFAGSRRELELPIDWSGATGPHLAVLRCLVATVGWGRTVTYGELASRSG
                     VFTDPSEPGVPARTVGQMMGANPLPLLVPCHRVVAADGLGGFGGAWHGVETKRWLLTLE
                     GVLPPTLDWSGPTA"
     misc_feature    complement(14713..14728)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.73"
                     /tool="antismash"
     gene            complement(14802..15026)
                     /locus_tag="HUT16_RS14780"
                     /old_locus_tag="HUT16_14775"
     CDS             complement(14802..15026)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS14780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_14775"
                     /product="hypothetical protein"
                     /protein_id="WP_176188641.1"
                     /transl_table=11
                     /translation="MPGSMTLGHTDTLVMLDHGDAERLAALLAGLSAMAASGRLSTEQL
                     AALGSGEAPDRAELATWSRTLAAHLRDHL"
     gene            15168..16490
                     /locus_tag="HUT16_RS14785"
                     /old_locus_tag="HUT16_14780"
     CDS             15168..16490
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136551.1"
                     /locus_tag="HUT16_RS14785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14780"
                     /product="chloride channel protein"
                     /protein_id="WP_176188642.1"
                     /transl_table=11
                     /translation="MPAEAAGTSPSPGLRELLRSPGYGRLLLVSALVGVPVSLAAFGFV
                     SLEHELQHWVWESLPRSWGYAHAPWWWPLPALALAGLLLAPIVTRMPGRGGHVPVLGLG
                     GPPTLPVEVPSVVLAALAALPLGAVLGPEAPLMALGSGLALLTVSAAKRAASPVVGPML
                     GAAGSTAAIATIFGSPLVAVVMMIEAAGLGGAQLTMLLLPCLLASGVGALVFTGFGHWT
                     GLSIGALSLPSVPQAQLPDVGDFLWGIPLAVVIAVVLVAGQTLGYRSAAFTAHRTAVRT
                     VLCAVLVGVCIAGYALVTGRSPEEAALSGQATLGQLAADPQSWPVGALLALVLFKGLGW
                     GVALGSLRGGPIFPAVLLGAALGVAAGGLPGMGIESGLAVGLAASSAAVTRLPVTSTVL
                     ATALLGSQAPDSMPLLIVAAVVAFLTATLVHRVAAPEHSLR"
     gene            complement(16561..16746)
                     /locus_tag="HUT16_RS14790"
                     /old_locus_tag="HUT16_14785"
     CDS             complement(16561..16746)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT16_RS14790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT16_14785"
                     /product="hypothetical protein"
                     /protein_id="WP_176188643.1"
                     /transl_table=11
                     /translation="MLSTDYRPDPGWPRRTTDPPPELHASVRPHGKEKSMSSARRTATA
                     RRTATAPRTRRDIAWS"
     misc_feature    complement(16729..16746)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.83"
                     /tool="antismash"
     misc_feature    complement(16740..16757)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.36"
                     /tool="antismash"
     misc_feature    complement(16741..16743)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16818..19730
                     /locus_tag="HUT16_RS14795"
                     /old_locus_tag="HUT16_14790"
     CDS             16818..19730
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010044234.1"
                     /locus_tag="HUT16_RS14795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT16_14790"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_254897810.1"
                     /transl_table=11
                     /translation="MLGTLTAHDGTADRPVRGPKARTLLAVLLLNADRPVSLDRLVDAL
                     WGDRAPATAEASLRNLVARLRRALADEEGTRLRATPAGYRLVVADEELDTRRFEVAVRR
                     ARAAHEAGDLPAVLAETATALGLWRGEPLADLPEPAGAGAACEQWRESRLQALEWRFDA
                     ELRLGRPHALVPELTRLVGEHPLREAFHAQLMRALQQTGDRARALAVHQRLRAALVEEL
                     GVEPGPAVREAHRRLLAEPPPAGPVPGPDAAPAGPVASGGPDGRPRPSQLPAPAAHFVG
                     RREQLGVLRRALLDGSGRPAVAVVSGMAGVGKSALAVHCADALRADFPDGQLFLNLRGA
                     TPGLAPLTPHAALTALLRGLGTAPGAVPADADSAAALLRTTLTGTRTLLVLDDAADPAQ
                     VRPLLPAEPGCAVLVTGRTPMHTLDHTLHLRLDALSERDGIALVERTAGRATVDRSVVA
                     IEQADLARLVRLCGRLPLALRIAGARLAARRTLPVRGLVGRLEEHEDRLDELELDDLSI
                     RQSLALTYDALRASARRPDLRAAAALAAIGAIDLPDYSAPLLAAVLGITPAQAGAALDR
                     LVEVALLDEPGPDRYAPHDLVRDYARELVPDPAERTRHVRAAFGWYLSVAVRIALALDP
                     KTHQLRRLPPVDGADRLDGDAALALGDAEFGNLSTLVERVAAEPWATAAEVSLPVRALA
                     PYLRVRRHSESFRLNELVHRLALRDDDRTALAHALSDMAHVHFVTGQNLRGVELIDRSL
                     ALVDDPVHRGTLLSNRGLLLSHLGRVQEAVTSLEEALDLAVRTGDLRSEATVLSALGNL
                     VEAEDPHLAIAHHRRSVEAGRRCDFGDAVCAGLANIGFAHLRLDDPATALDYFARATAP
                     SPWVVPWHVALENGRGQAEALRRVGRPAEALELVRGLLEQATALQDAFAAGTIEHTHGL
                     VLRDLGRLAEARTAWRAALERLGASGHKAVAELHELLAAG"
     tRNA            complement(19811..19887)
                     /anticodon=(pos:complement(3359380..3359382),aa:Thr,
                     seq:tgt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUT16_RS14800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUT16_14795"
                     /product="tRNA-Thr"
     gene            complement(19811..19887)
                     /locus_tag="HUT16_RS14800"
                     /old_locus_tag="HUT16_14795"
     misc_feature    19846..19859
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.15"
                     /tool="antismash"
     misc_feature    complement(20088..20103)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.79"
                     /tool="antismash"
     misc_feature    complement(20880..20900)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.13"
                     /tool="antismash"
ORIGIN
        1 ggcccagagc agttggaagc ggcggttgcg gcgcagcggc accgcggcgg tgtccggctc
       61 ggtcgtcgtg gtcatccctc gtaccccgtt catgtccccg tccacgttca tgttcaagca
      121 accattcacg cctgcgtgaa tggttgcacg gccgagaacg attgcacaag cgttgacgct
      181 gtggctgaat gtgaacgtgg ctgatcggac gaaggagcgc gaggtcaccg acgtcgcgac
      241 gctcaaggcg ctggccgacc cgctgcggct ggccgtgctc ggggcactga tgaagcacga
      301 ccccgagccg aggtcggtga aggaggtcgc ggcggagctg gacgaggcgc cgaccaagct
      361 gtaccggcac gtcaagcagc tggagcaggt cgggctggtg tacgtggcgg agacccggct
      421 ggtgtccggg atcgtggaga gccgctaccg ctcggcccag cagtcactgc ggctgtcgcc
      481 gcaggtgtac gcggagggcg acgagccgcc gcccgcgctg ggggcgatcc tcgccgcgat
      541 ggacctggtg cgctccgact tccggcgcca cttcctggcg ggccggatcg acctgacccc
      601 ggcggcgcag ggcaacccgc agcccggcaa gttcgcgcac gccaccttcc ggctcagccc
      661 ggaacggctg cggcggctgc gcacccggct cgacgaggcg ctggacgagg tgttcgcgga
      721 gggcgactcc accgacccgg acgccgtcga ggtcgcgctg ttcgccctgc tgtacgccgt
      781 gcggccgccg caggcggagc cgggccagga gcgggcgccg gagcgggact agacgtaccg
      841 ctccagaatg gaggactcgg cgagccggga caggccctcg cgcaccgagc gggcccgggt
      901 ctcgccgacg ccctccacgg tctgcaggtc gtcgatggac gcggcgagca gcttctgcag
      961 gccgccgaag tggtcgacca gccgctcgat gacggtgttg ggcagccgcg gcaccttggc
     1021 cagcagccgg tagccgcgcg gggagaccgc ggagtccagc gactcggggg tgccggtgta
     1081 gccgagcgcc ttggcgacgg tctgcaggtc cagcagctcg gcgtgggtga gcgcctccag
     1141 gtcggagagc acctcggtga cggtgcggcc cttcttggcc gcccggtccg gaaagtagtc
     1201 gcgcacgacg agctcgcgct ccggctcgac gcccgcgatc agctcgtcca gctgcagcga
     1261 cagcagccgg ccgtcggtgc ccagctccag cacgtacccg gcgatctcgc cggcgatcag
     1321 ccggaccatc tccaggcgct gcaccaccgc cgagacgtcc cggacggtga ccaggtcctc
     1381 gatctccagg gcggacaggg tgccggccac ctcgtcgagg cggagcttgt agcgctccag
     1441 ggtggccagc gcctggttgg cccgggacag caccgtggtg gagtcctcca gcacccggcg
     1501 cgcgccgttg acgtagatgg cgatcagccg catcgagtgc gagaccgcga ccaccgggta
     1561 gccggtctgc cggttgaccc gctccgcggt gcggtggcgg gtgccggtct cgtcggtggg
     1621 gatgttcgcg tccggcatca ggtggacgcc cgcgcgcagg atcttggtga ggtccttgtc
     1681 catgatcacc gcgccgtcca gcttgcacag ctcgcgcagc cgggtggcgg tgaactcgac
     1741 gtccagcacg aaaccgccgg tgcacagcgc gtccacgctc ttgtcgaagc cgaggacgat
     1801 caggccgccg gtgttggccc ggagcacccg ctccaggccg tcccgcagcg ccgtgcccgg
     1861 cgcgatcgca ctgagggaag cccgcagcag ggcctcctcg cgggaggact tgtccgcccg
     1921 gtcgatggct gccacgtgac tccttgggcc gaccctaacc gtgtgccgcg gcggccgacg
     1981 gtctgtctgt tgttgctgcg aatgatgccg atgagcaggt gaagtctaac tgcgtacggc
     2041 ctcggcgggg cgtgggtcaa gccagttcgt ccgagtcgac cggctcccag cccgccatca
     2101 gctcctccgg gaaggccggg acgggggcct gggcgcgggc ccgggcgagc gcctgggcgg
     2161 ccggatccgc ggccgggcgg accggcggcg cggcgtcctg acgggccttc gagcgggggc
     2221 ggcggccggg gatcgcgcgc agcgcctcgc cgatgtcgga gacctccacc accgtcatgc
     2281 ccgccgggac cttgcccgga tccggcggga cgagggcgtg cgtgaagccg agccggtgcg
     2341 cctcggcgag ccggcgctgc acgcccgtca cccgccgcac ctcgcccgcc aggccgacct
     2401 cgccgatcgc caccaggttg ttcggcagcg gcgtgtcggt cgaggaggag gccaccgcca
     2461 gggcgatcgc gaggtccgcc gagggctcgg tgagcttcac gccgccgacg gtggcggtgt
     2521 agatgtcctg cttgccgagc ttcacgccgc cgtgccgctc gaccaccgcc aggatcatcg
     2581 cgatccgcgg cgactccagg ccggaagtgg tgcgccgcgg cgaggggatc tgcgagtcga
     2641 ccatcagcgc ctgcacctcg gccaccagcg ggcgcttgcc ctccagcgtg accgtcaggc
     2701 aggtgccggg gacgggcttg tcgcggcggg tcaggaacag gcccgagggg tcggccaggc
     2761 cgacgatgcc ctcgtcgtgc agctcgaagc agccgacctc gtcggtcgcg ccgtaacggt
     2821 tcttgacgcc gcggatcagc cgcagccggg cgtgccggtc gccctcgaag gagagcacca
     2881 cgtccaccag gtgctccagc aggcgggggc cggcgatctg gccgtccttg gtgacgtggc
     2941 cgaccagcag ggtggccatg ccgcgctcct tggaggcccg gatcagcgcg cccgccacct
     3001 cgcggacctg cgcggggccg ccgggggcgc cgtccagctc ggcggaggcg atggtctgca
     3061 ccgagtcgag gaccagcagg ccggggttga ccgcgtcgat gtggccgagc accgcgccca
     3121 ggtcctgttc ggcggccagg tagaggtgct cggagagggc gttgatccgg tccgcgcgca
     3181 gccgcacctg gccggccgac tcctcgccgg tgacgtacag cgtgcggtgc cggtcgctcg
     3241 cggccttcgc cgccacgtcc agcagcaggg tggacttgcc gacgccgggc tcgcccgcca
     3301 gcagcaccac ggcgcccggc accaggccgc cgccgagcac ccggtccagc tccgggacgc
     3361 cggtggtgcg ggcggtggcg acctggccgt ccacctgcgc gatcggcttg gcgggcgcgg
     3421 agaccggccc ggccgcggtc gtccggatcg gcaccgcgcc gtactcctcc accgtgcccc
     3481 aggcgttgca ctccgtgcag cggccgaccc acttgagcag ttgggcgccg cactcggtgc
     3541 agcggtacga ggggcgcggc ttcgcggtgg tcttggtacg ggcagccatg cgggccacgg
     3601 tagcgcctcg caccgacagc gcccggacgt cactcgaacg gcgtcaaccg ggcgaacaag
     3661 gaatcggtcc tgttacccga aaggaggaca accggccgaa accctccggg cgacgggttt
     3721 cggctgccta ccgtcgatcg ggtgaccacc ggccagcccc accccgtcgg cccgtccccg
     3781 gtactccggg cgtacggcgc gtgcgtcgac gggctgttca cctactgcct gtccgtgctc
     3841 tgcgagcacg aagccgccac cgcggccgtc ctggaggtcc gcgacctggc ccagcgccac
     3901 ggcgaccgga tcgacgaccc ggcgctgctg cgcgcctggc tgtacgcgct ggcccggcac
     3961 cgctgcctgg cccggctcga cggtgaggcc gagcaggacg gcgcgccccc gcccggctcc
     4021 cggggcccgt ccgggcccgg cgcggtccgc gagcggcgcc gcgaactcgc ctcgctggcc
     4081 tggccggagg cggccggcac cgacccggag cagcgcgagg cgctggagct ggcggtgcgg
     4141 caccggctgg acggcgcgga ggtcgcggcg gtgctcggcc tgagcaccga ggccgcggcg
     4201 gcgctgctgg acgcggcggg cgccgaggtc ggccggacca ggacggcgct gctggtgctc
     4261 ggcgtcggct cctgcccgga gctggcccag ctcggcggcg tcggcgcgga gtcctggcgg
     4321 ggctgggtgc tgggcccggc gctgcgccgg gagctggtgg tgcacctggt ggagtgcccg
     4381 acctgccggg gcaccgcgga gcgggtcgcg ggccagctcg ggcacggcct ggcggggctg
     4441 cccggcctgc cgctgctggc cgcgccgggg ccgctgcgcc cggcggccgc gccgccgtcc
     4501 ggcggtacgg cgttcctggc gggcgcggcg gcgggccggc ggatcgcgca gggcccggtc
     4561 ccgccgcggt tcgaccagcg cggcttcccc ggcaccgggt cgccccggcg ccgcgcggtt
     4621 cggcggtgcg gcagcgggtg gtgaccaccg gggtgctggc ggcggtgctg gccgcgccgg
     4681 tggtggcgct gtggagcgcg caccggggcg gcggggagga ccacgcctcg gcggtgtcct
     4741 cggtgcgggt ggacccgacg gccgggcccg ggcagcgcgt cccggtgccg gagccgacgc
     4801 cggtggcggt gctgccgccg gtcgcccggg tggcgacgat ggagctggcg ggcgtggtga
     4861 ccgcagaaac gtccctgccg agcgttcagg gcgcggccgt gccggtgccc tcgcacgggg
     4921 ccgcgccgct gtccagcccc gcgctgaccg ccgagcccgg cccgccgccg tccgccaccg
     4981 cgagccggct gaccgtgcag gccggcgcgt acggcaaccg gaccgtgctg acgctgacca
     5041 attccggtga cgggccgctg tcctggcacg ccgtgctgga cgtggactgg ctgcggctga
     5101 gccgggactc cggcaccctg gagcccggcc agcggatcac cgtgacggtc acggtggacg
     5161 aggcgcgcgc cccgcgctcg cgctggacgg cgcacctggc gctgccgccg tccagtgccg
     5221 tggtgaccct ggagggcggc accgaccacc gcggcgtgcc cactccggac ggcccgtcgc
     5281 ccgacccctc gccgacgccc acgccctcgg cttcggcttc ggcttcggcg agcgcctccg
     5341 acccggcccc ggcgagcccc tcgccgtccg ccccgtcctc gccgcccgcc tcctcctcgc
     5401 cgccacccgc ctcgccgagc ccgtccccgt ccgccccgtc cgggtctccc gactcctccg
     5461 gctctcccgg gtccaccggc ccgtccgcgc cggtgtcgcc gccgccctga cggtcggtcc
     5521 gccgcaggga gctcgcccgc cgggcggcgc tcaccgcggg ccacggcctc ctcccgcgag
     5581 gcgtccagga cggggtcggc gggaacgact ccgtccgggc cgagtgcccg ggccgacccg
     5641 gtgtgcccgg cgagccggac gaaggagggc tgcgccccgg cgacgatcaa ccgtccgccg
     5701 cgggcgccca gctcgtcgca cctgctccgc cgcagcccga ccgtgccgga cggcggcacg
     5761 tcggggacgg tgcgcaccac cggcaccggc ccggcgggcc cctcggggag cccggggccg
     5821 accgggaacg cggtgcggtc ggggcgcggc gcggggctga cggcaccggg accaccgcga
     5881 tcaccggcgg cgggccgacc gcggtaccga ccgccgggcc cggcgcccgc ccggtcgcgg
     5941 ccccccgtcc gtccgtctcc cccgtccgtc cttctgccgg gtcagcgcag ccggatggcc
     6001 gggagccggt agctgccgtc gagcaccgcg tcctgcggct ggtacatccg caccatcggc
     6061 cggaacccgc cctcgggcgc gggcagccag ttcgcgagct cctcggggtc ggtgggccgc
     6121 cggtgctgga cgtacagggt cagcgagccg tcctcgccgt gcaccaggcc gggggtgcgg
     6181 tcgccgatcg agtaccggtc gatctcgttg ccgaccagca ggtagtccgg ggtgccgtac
     6241 atcgtcaccg accagaacgc gcccaccggc ggggtctgct cgaagcgcag ggtgtacgcg
     6301 tgggcgccgc tcagcgggac gccgtccgcg tcgttgtagg tggtggcgta cgcggcctcg
     6361 taggcgtggt tgccccacag gccggcccgg gcggcgaccg cccgggtcag gtaggcggcg
     6421 cggcggtcgg cgatccgcca ctgcggctcg tcccgggtgc cggggccgag gaagtccagg
     6481 ttgtagtcga acaggtgcag gttggccgtc cactcgccgg tggggtcgcc ggcgccgacg
     6541 gtcgccgcct ccacccgttc ccggcccgcc gccaggccct tggccagcgc cgccgcccac
     6601 tcggcggggc cgtccaggta cggcgagcgg ccctggtcga gcaggccgat cggggcgaag
     6661 cgctgctgga aggcgacgtc gtcggcggcg ggcgggaagg ccgccgccca ccgccgcagc
     6721 cgctccagga agagcagttc cgccgggacg ccggcgtccg gctccggcag cccggccggg
     6781 gtgccgccgt ccgcgagcgg ggtgagcgtc agctgccgct gaaggtcccg gacccgcggc
     6841 aggtcgtccg gcccggcgca gtagttgcgc accgcgagca ccgccaccgc cgtcggcgcg
     6901 gtgatcaccg gcacgccctc cggggcggtg ccccgccagc cgggcggggc gaccagccag
     6961 gactgctcgg cggtgccgga cgaacggcgg cccgcgtagg cgaagttgtt cgtccaggcg
     7021 tcgatgaact ggagcacgtc gtacgcgccg ccggtgtccg ggacgtgcag cagcagcggg
     7081 ccggcggaca ggtccagcgg ggcgaccgag tacaccgtgt cgttgttcac cgacacgaac
     7141 tcggcgtgct ggtcggcgag ccggtcggcg tggccgaagg agttccactc cacggccggg
     7201 atcgacccga tgccccggcg gtggatcgtg tccaccgtgg tcaggttggc gaccagcggg
     7261 gagccgtaca cgaaggcctc ggcggccagc atctcgggcg tggcgtcagc catgcgaacg
     7321 tccttgtctg atcggtgact tcatcggggg gtcaggtcgg gcagccgcca gctgccgtcc
     7381 agcagttcgg gcccggggcc gtaggcgcgc accgcgacgg agtacgggcc ctcgggggcg
     7441 ggcagccagt tcgccgcctc ggccgggtcg gtggggcgcc ggtgctggac gtacagggtc
     7501 agcgagccgt cctcgccgtg caccaggccg ggggtgcggt cgccgatcgc gcaccggtcg
     7561 gtcccgtcgt cggccgggag ccgttccggg agccggtgca ccgacgccga ccagaagaac
     7621 cgggccggcg ggagccgccc gggcgcgaag cgcagcaccg cgggctccag gccgcccgcc
     7681 gtccacggcc ggccgtcgcc ggaccagacc tcctccgcgg gcaggccgta caggcccgtg
     7741 cgggcgccca gcgcccggtt caggtggtcg gtgccgagct gctcccgggt gccggaccta
     7801 accgcgccgg cggtcgcccc ctcgacggcc cgggccagct ccgcccgggc gtccgcgatg
     7861 cccgccagca tcgcctcgcg cacctcggcg ggcagcgccg ccggctcgaa gtcgccgctg
     7921 ccgacgccca gttcggtcag ccggccgcgc aggtcggcgt cggcgggcag ggccgggaag
     7981 aagcccagca ggaagtcgag cagcgagaag aactccaggg tgccgagcac ctcctcgccc
     8041 cgccacaccg gccacaccgg ctccccggcg accggtcggg gcgtgcccag gtgctcgctc
     8101 agcggcttga gcaggtaccc ggcctgcacc cgctcgacct ccggcgcgtc cccctccccc
     8161 gccgaggccg tccgcccgac gatgcccacc aggttcccgt cggcccgcag caccccgtcg
     8221 aagccctccg gcgggttcgc ccggtgcccg ggcccggcga tcaggtagcg gcccgcgccg
     8281 tccccggtgg tccgcgagcc gacgaagccg acataggcgg tgtccaggtc gtgcaccggc
     8341 agcacgtggt agcggccggt cgccggcttc tccagcaccc acggctcggc ccgcaggtcc
     8401 agccaggccc acgagtgcgc ggtgtcgcgg tcgggcgtca ccgcgtcggt gccggccgcg
     8461 gcggcgggct gcgggtggtg ccggaacacg ccgaagcccc cgacgtaccg ggggtccgcg
     8521 tcgtcgatcg cctgcgggta gagcatccgg tagttctcca gcatcgggta gccccaggtc
     8581 cacgcctgcg ccgccgtccg ccgcaccgcc gccggatccg caccgaccgg gttccccatc
     8641 tcgcccaccc tcctaccccc cgcgaaaggg gcaattcaga cataccggta caccgggatg
     8701 ctatgtgctg accccccgat cggcactccg ggcaccaccc cgccgcgcgc ctgaccgacc
     8761 gtctgctccc ggcgtaaccg ctccgctccc ggcgaacgcg gcgcatggac cgccgccgct
     8821 ccggagaccc tgcggggcat ggacatcctt ctgctcggcg gctccaagtt cctcggcctc
     8881 gcctacgcca ccgaggcgct cgcccgcggc caccgcgtca ccaccttcaa ccgcggcgtc
     8941 agccgcaccg acccgcccgg cgtcgaagcc gtccacggcg accgcgcgaa ccccgacgac
     9001 ctgcgccgcc tcgtcgaagg acggcactgg gacgccgtcg tcgacacctc cggccagcag
     9061 ccccacgacg tcgccaccgc cgcccggctg ctcagcggcc gcgccgggca ctacggcttc
     9121 gtctcctccg tccacgcctt cgccgactgg cccgcccgcc cggtcgacgc cgactccccc
     9181 accctcgact gccccggcga cctcccgccc gaccagccct tcgccaacgc gctcaaggcc
     9241 gggtgcgaac gcgccctgcg cgaccacttc gacggacccg ccgcgatcct caactgcggc
     9301 ctgctgatcg gcccgcacga acccatcggc cggctcccct ggtggctcga ccggatcgcc
     9361 cgcggcggcc gggtgctcgc ccccggcacc cccgaccgcc cgctcagcct gatcgacgcc
     9421 cgcgacttcg ccgcgttcgg cctcgacctc gcgcagcggc gggccgccgg acgctacctc
     9481 accaccgcgc cgatccgctc gacgaccacg ggggagttcc tcgacgcctg ccgcaccgcg
     9541 accggctccg acgccgaact cgtctggacg ccggacgccg acctgctcgc cgccggggtc
     9601 tccccctggg tggaactccc gctctgggcc cccgccgccg acggctggca cggcacctgg
     9661 cgggccgacc cggcgaccgc gctcgccgcg ggcctgcgcg tgcgcccgct gctcgacacc
     9721 gtcaccgaca cctgggcctg gctcgaagcc ggcggccgcg cggaggtcgc ctaccggcag
     9781 ctggacacgc cgctggggat cgacccggcg aaggagcggg agatcctcgc cggggcgtga
     9841 gcgtgcaggg gctcggggaa cggcgagtcc gtgctgctga cggccggagc ccatcggagg
     9901 tccgtgctgc cgcgtcgcag tatcagaacc ggaagccgat gcgtgctccg gcggtgaacc
     9961 gtcagcagcc ccgagttcgc cgttccccga gcccccgggt tcagtaggtg cggcgggtga
    10021 cgagttcggc gagggccagg aggtcgtcgg cgcgggcggg gtcggggacg gcggcggcga
    10081 ggtgggcgat ggcggcggcc atccggtcgc agctctcggt ctgggcccag ttgcggccgc
    10141 ccgcccggtc caccgcgtcg gcggcggcgg cgagttcggc ggggctgagc gggcggccgg
    10201 tggcgtagag cgcggcgagc tccgcaccgg ccggggtgcc ggaggagagg gcgtggacca
    10261 ccgggaggga cttcttgcgg gcggcgaggt cggcgcccac cggcttgccg gtgaccgccg
    10321 ggtcgcccca gatgccgatc aggtcgtcga tcagctggaa ggcgagcccg atctcgcggc
    10381 cgaaggcgtc catcgcgtcg gcggtctccg cgtccgcccc cgcgtacagt gcgccgagcg
    10441 cgcacgcgca gccgagcagg gcgccggtct tgccctcggc catggcgagg cactcggcga
    10501 gcgtgacgtc ggtgcgctgc tcgaaggagc agtcggcctg ctggcccgcg cagagctcga
    10561 ccacgcagtc ggcgaggcgg cggacggacg ccgaggccgc cgggtgcggg tcctcggcga
    10621 gcacccgcag ggcgagggag tgcatggcgt cccccgccag gatcgcgccg gtggtgccga
    10681 acacccgcca ggcggtgggg cggtggcggc gggtgtggtc gcggtcgagg acgtcgtcgt
    10741 gcagcagggt gaagttgtgc accagctcga cggcggccgc ggcacggacc gcgtcctgcg
    10801 ggcggccgcc gacggcggtg gtggcggcga gcaccagcgc cgggcggatc gacttgccgg
    10861 cgccgaccgc gctgggggcg ccgtcggcct ccagccagcc caggtggtag ccggcgacca
    10921 ggcgcatcga gtcggggagg gtgtcgacgg cggcgcgcag cgcggggtcg acggtggtgc
    10981 gggcccggga gagcagggcc atcgcctcgg cggtgtcgcg ccccccgtcg acggccgggg
    11041 ccgccgcccg ctcgccgtgc tggtcgcgtt cgggcacggt gatggccatg gtgaagtcct
    11101 ccccctcggc cggccccggc tgcggggcgg cgggaatgct tgctgacgga ccgtcaggcg
    11161 gtggaacggg cgggcccagg acggtgggcc cgcccggtgg tcagtgctgc cagtgggcga
    11221 cgttcacgtt ctccagcacg ccgatggcgt cggggacgag gatcgccgcc gagtagtagg
    11281 cgctgaccag gtaggagatg accgccttct cgtcgatgcc catgaagcgg acgttcaggc
    11341 ccggctcgac ctcgtccggc agcgcgccgg ggcgcaggcc gatcacgccc tggttgtcct
    11401 cgccgacgcg catcgccagg atcgaggtgg tgccgtcgac caccgggatc ttgttgcagg
    11461 tgaggatcgg gacgccgcgc cagctgggca ccgtccgccc ctcgaaccgg atcgcctccg
    11521 ggtacaggcc gcggctgttg cactcccggc cgaaggcggc gatcgccttg gggtgggcca
    11581 ggtagaactt ggtgctgcgg cggcggcaga gcagttcgtc caggtcgtcc ggggtgggcg
    11641 ggccggagtg ggtctggatc cgctggccgt actcggcgtt ggccagcagg ccgaactccg
    11701 ggttgttgac cagctcgtgc tcctgccgct cgcgcagcgc ctcgacggtc agcttgagct
    11761 ggtgctcggt ctggtccatc ggcttgttgt agaggtcggc gacccggctg tgcacccgca
    11821 gcaccgtctg ggcgacgctc aactcgtact cgcgcggcgc gagttcgtag tccacgaagg
    11881 ccgtcggcag gacgggctcg ccctcgtggc cggccgacat gccgatcgcg gcctcgccct
    11941 tgtgggtctg cgggagctgc gagtcggcga tgaaggcgag gatctggtcg cgcagcgcct
    12001 cggagcggtc ggcgagctcc tggaaggcgg gccaggcgag caccatcacg gtgccggcgg
    12061 tggcggcctt gacgctgtag ggccagcggc ggtcggcgac ggtgagcgcc tcgtcgccga
    12121 tgtggtcgcc gtccgcgaag gtgcccagga ccgtcgggtc gccgtacttg ccggtgccga
    12181 ccttgtcgac cttgccgtgc gcgaccaggt agacctcgtc gatctcgcgg ccctgctcga
    12241 tcagcacctc gccggccgcg aagtcccgct ggacgaagcg gccggccagc tcggccagca
    12301 gcgcgtcgtc ctcgaaaccg cgcagcaccg ggacctcgcg cagcgtcggc gggacgaccg
    12361 cgacctcccg gccggtccgg acgaagccca cccggccgcg gccgaccgcg tacgacagcc
    12421 gccggttgac ccggtaggtg ccgccggaga cctcgaccca gggcagcgcg cggagcagcc
    12481 agcggttgct gatctcctgc atctgcgggg ccgacttggt ggtcgacgcg aggttcttgg
    12541 cggccgccac cgagaggctg ctccgcggcc tcgtctgggg aattccggcg gtggtttcgg
    12601 tcgtcatttc cgaggggccc ctgatcgtgt cgacggcacg ttgcggcaac catgctgacg
    12661 tccgttcagg tgaggcggca atcactcgtg ggggtgattc gggcgcatgg acgcaatagt
    12721 gcgaccagcg caccggggcg cccgggcggg gtgtgcggac cccgcctccc gggcccccgt
    12781 tccaggcgtc cgcgctgctc accgcccccc tgttcgaacc gcggcggaac agcgctaagg
    12841 tggccccctc accgcgtggt gaccgccgcc acagggcagg cgaaccggtc ggtgacctcc
    12901 catcggcacg cccttctcca gggagacctt cgtgaccgcg cccgtccgcg tctggctgaa
    12961 ccgcacctac gccgagaacg tcttcttcat cgacctgctg cgggccgcac cgcgcccggt
    13021 gcacgtcctg gccacccacg tcgaccccga ctcccccgtc atcgccgccg ccgacctggg
    13081 cgccctcgaa ccggacgggc tgaccgccga ggcgtacgtg gaattcgcgc tggaattctg
    13141 cgcccgccac gacgtggacg tgttcctgcc ccgcctgcac cagttggcga tatcgctgcg
    13201 ccgccgcgac ttcgaggcgc tgggcaccgc gctggtctgc ccgcccgcct ccgcgatatc
    13261 gctgttcgcc agcaaggtcg acggctaccg ggcgctggac gcggtcgggc tgcccacccc
    13321 gctgtggcgg caggccggca ccgcgtccga actgctcgcc gccgtcgagg agatcgaggc
    13381 gaccggctcg gccgcctgcc tgaagccggc ctccggcgcg ggcggcgagg gcttccgcgt
    13441 cctcacccgg gagccgttca acctcggccg gctcgccggc tacgtcgacg cgcgggtcca
    13501 actcgaccag gtgctgggcg cgttggagcg gtccgccgcc cccgccgaac tgctggtgat
    13561 gccctacctg gacggccccg aggtctcggt ggactgcctg gccgagcagg acggccgggt
    13621 gctggccgcg gtcggccgca ccaagcaggg ccgccgccgc ggcttcaccg tcgacccggc
    13681 ctacctggaa ccggcccgcc gcctggtggc ggagttcggc gtcggccacc tgtccaacgt
    13741 gcagttccgg cacgagcgcg gcaccgggcg cccggtcgtc ctcgacgtca acacccgccc
    13801 gtccggcggg ctgcaccagc tccggatgtg cgggctcaac ctgcccgccg cggccctcga
    13861 actcgccctg ggcgcccggc cgtcgctgcc cgccgcggac gagctcacgc tcggcgagta
    13921 caccctggtc tccgccatcc aggcggtgct gccccggcag tccgcggcgc ccgcgctgga
    13981 acgcctcgac ggcgcggagc ggcggcccgc cgcgaccgtc gcggtgtagc ccccgccgtt
    14041 cgctaggccg tcggcccgga ccagtccagg gtcggcggca gcacgccctc cagggtgagc
    14101 agccagcgct tcgtctccac cccgtgccac gccccgccga agccgcccag cccgtccgcg
    14161 gccaccaccc ggtggcaggg caccagcagc ggcagcgggt tcgcccccat catctggccc
    14221 accgtccggg ccggcacccc cggctcggac ggatcggtga acaccccgct gcgggaggcg
    14281 agttcgccgt aggtgacggt ccggccccag ccgacggtcg ccaccaggca gcgcagcacc
    14341 gccaggtggg gtccggtggc gccgctccag tcgatcggca gctccaactc ccgccgcgag
    14401 ccggcgaagt actcgccgac ccgggcccgc accaggtcgg cccgccgctc gtcggtgcac
    14461 tccggaacgg gcgtgtcgca caggtagctc gcggcggcca ccccccggtc ggtcaccgcg
    14521 aaccgcatcg ggccgctggg caacggggtc gggacggtca cccaggagag ctgcatgctc
    14581 cccactctag gacttgcagc atcaggggct cgggagagcg ccatcagggg ctcggggaac
    14641 ggcgaggccc gggctgccgg cggtgcactg ccgtggcgcg catcggcttc gggttctgtt
    14701 caggacacgc agcagcacgg accttcgatg ggctccggcc accagcagca cggccccgcc
    14761 gttccccggg cccctggttt cgcttccgcc gtgccggaag gtcagaggtg gtcgcggagg
    14821 tgggccgcga gggtgcggga ccaggtggcg agttcggcgc ggtcgggggc ctcgccggag
    14881 cccagggcgg cgagctgttc ggtggagaga cggccgctcg cggccatcgc ggagaggccc
    14941 gcgagcagcg ccgcgaggcg ttcggcgtcg ccgtggtcga gcatcaccag ggtgtcggtg
    15001 tggccgaggg tcatggaacc gggcatcgcg tcctcctcga tcggtcctgc gtccaccgta
    15061 cgaccgaggg ggcgccgctc gcccgttcgg cccaccccgc tggcccgggt gcgggtcggc
    15121 ggcggacggt cggggcaggt gtgtccgccg ggtgacaggg agcgcagatg ccagcagagg
    15181 ccgccggtac gtccccgtcg cccggcctgc gcgagctgct ccgcagcccc gggtacgggc
    15241 ggttgctgct ggtgtcggcg ctggtcggcg tgccggtctc gctggcggcg ttcggcttcg
    15301 tcagcctgga gcacgagttg cagcactggg tgtgggagtc gctgcccagg tcctggggct
    15361 acgcgcacgc gccgtggtgg tggccgctgc ccgcgctggc gctggccggt ctgctgctgg
    15421 cgccgatcgt gaccaggatg ccggggcggg gcgggcacgt gccggtgctg gggctgggcg
    15481 ggccgccgac gctgccggtg gaggtgccgt cggtggtgct ggcggcgctg gcggcgctgc
    15541 cgctgggtgc ggtgctcggc ccggaggcgc cgctgatggc gctgggcagc gggttggcgc
    15601 tgctgacggt gagcgcggcg aagcgggcgg ccagcccggt ggtcgggccg atgctggggg
    15661 cggccgggtc gacggcggcg atcgccacga tcttcgggag tccgctggtg gcggtggtga
    15721 tgatgatcga ggcggcgggc ctgggcgggg cgcagctgac catgctgctg ctgccgtgcc
    15781 tgctggcctc gggcgtcggg gcgctggtgt tcaccgggtt cgggcactgg acggggctgt
    15841 cgatcggcgc gctgagcctg ccgtcggtgc cgcaggcgca gctgccggac gtcggggact
    15901 tcctgtgggg gatcccgctg gcggtggtga tcgcggtggt gctggtggcg gggcagacgc
    15961 tggggtaccg ctcggccgcg ttcacggcgc accggacggc ggtgcgcacg gtgctgtgcg
    16021 cggtgctggt gggggtgtgc atcgccgggt acgcgctggt gaccgggcgt tcgccggagg
    16081 aggcggcgct gtcggggcag gccacgctgg ggcagctggc ggcggacccg cagagctggc
    16141 cggtgggggc gctgctggcg ctggtgctgt tcaaggggct gggctggggg gtggcgctgg
    16201 ggtcgctgcg cggcggcccg atcttcccgg cggtgctgct gggcgcggcg ctcggcgtgg
    16261 cggcgggcgg cctacccggc atggggatcg agtcggggct ggcggtgggg ctggcggcga
    16321 gcagtgcggc ggtcacccgg ctgccggtga ccagcacggt gctggcgacg gcgctgctgg
    16381 ggagccaggc gccggattcg atgccgctgc tgatcgtcgc ggcggtggtg gcgttcctga
    16441 ccgcgacgct cgtgcaccgg gtggcggcac cggagcactc gctgcggtag ccggtcagcg
    16501 ggcgcgacgg ggcggggcgc ggcggggcgc ggcggggcgc cggccgtggg gcgggccggg
    16561 tcaggaccag gcgatgtccc gccgggtgcg gggggcggtg gcggtgcggc gggcggtggc
    16621 ggtgcggcgg gcgctgctca tgctcttctc cttgccgtgc ggccggacgg aagcgtggag
    16681 ttccggcgga gggtccgtgg tgcgacgggg ccagcctgga tcgggccggt aatcggtcga
    16741 taacatctgc ctaacgtgca ccgatgggga gtcgggcggg gcgcacgcgg acagggagca
    16801 ccacggtgcg cttcggcttg ctcggaactc tgacggccca cgacgggacg gccgaccgcc
    16861 cggtccgcgg ccccaaggcc cgcaccctgc tcgccgtcct gctgctgaac gccgaccggc
    16921 ccgtctcgct ggaccgcctg gtcgacgcgc tctggggcga ccgcgccccc gccaccgccg
    16981 aggcctcgct gcgcaacctg gtcgcccggc tgcgcagggc gctcgccgac gaggagggga
    17041 cgcggctgcg cgccaccccc gccggctacc ggctcgtggt ggcggacgag gagctggaca
    17101 cccggcggtt cgaggtggcc gtccggcggg cccgcgccgc gcacgaggcc ggcgacctgc
    17161 ccgccgtgct ggccgagacc gccaccgcgc tcggcctgtg gcgcggcgaa ccgctcgccg
    17221 acctgccgga gccggccggg gccggggcgg cgtgcgagca gtggcgggag agccggctac
    17281 aggccctgga gtggcgcttc gacgccgagc tgcgcctggg ccgcccgcac gccctggtgc
    17341 ccgaactcac ccggctggtc ggcgagcacc cgctccgcga ggccttccac gcccagctga
    17401 tgcgggccct ccagcagacc ggcgaccgcg cccgggctct ggccgtgcac cagcgcctgc
    17461 gcgccgccct ggtcgaggag ctgggcgtcg aacccgggcc cgccgtgcgg gaggcgcacc
    17521 ggcggctgct ggccgaacca cccccggccg ggcccgtccc cggcccggat gccgcacccg
    17581 ccgggcccgt ggcgtccggc gggccggacg ggcggccccg gccgtcccaa ctgcccgccc
    17641 ccgccgccca cttcgtcggc cgccgggagc agctgggcgt cctgcgccgc gccctgctgg
    17701 acggctcggg gcggcccgcc gtcgcggtgg tcagcggcat ggcgggcgtc ggcaagtccg
    17761 cgctggcggt gcactgcgcc gacgcgctgc gcgccgactt ccccgacggg cagctgttcc
    17821 tgaacctgcg cggcgccacc cccggcctcg ccccgctcac cccgcacgcc gcgctcaccg
    17881 ccctgctgcg cggcctcggc accgcccccg gggcggtccc cgccgacgcc gacagcgccg
    17941 ccgccctgct gcgcaccacc ctcaccggca cccgcaccct gctcgtcctc gacgacgccg
    18001 ccgaccccgc gcaggtccgc ccgctgctgc ccgccgagcc cggctgcgcc gtgctggtga
    18061 ccggccgcac ccccatgcac accctggacc acaccctgca cctgcggctc gacgcgctct
    18121 ccgagcgcga cggcatcgcc ctggtcgagc gcaccgcggg ccgcgccacg gtggaccggt
    18181 ccgtggtggc catcgagcag gccgacctgg cccggctggt ccggctctgc ggccggctgc
    18241 cgctcgccct gcggatcgcc ggcgcccgcc tcgccgcccg ccgcaccctc cccgtccgcg
    18301 gcctggtcgg ccggctggag gagcacgagg accgcctgga cgagctcgaa ctcgacgacc
    18361 tgagcatccg ccagtcgctc gccctgacgt acgacgcgct gcgcgcctcc gcccgccgcc
    18421 cggacctgcg ggccgccgcc gcgctcgccg cgatcggcgc catcgacctg cccgactact
    18481 ccgcgccgct gctcgccgcc gtcctgggga tcacccccgc ccaggccggc gcggccctcg
    18541 accggctggt cgaggtcgcc ctcctggacg agcccggccc cgaccggtac gccccgcacg
    18601 acctggtccg cgactacgcc cgcgagctgg tccccgaccc cgccgaacgc acccggcacg
    18661 tccgggccgc gttcggctgg tacctgtcgg tcgcggtccg gatcgcgctc gccctcgacc
    18721 ccaagaccca ccagctgcgg cggctgcccc cggtggacgg cgccgaccgg ctggacgggg
    18781 acgccgcgct cgccctcggc gacgccgagt tcggcaacct gtccaccctg gtcgaacggg
    18841 tcgccgccga gccgtgggcc accgccgccg aggtctcgct gcccgtccgc gcgctcgcgc
    18901 cgtacctgcg ggtgcggcgg cactccgagt ccttccggct gaacgagctc gtccaccggc
    18961 tggccctgcg cgacgacgac cgcaccgcgc tggcgcacgc gctcagcgac atggcgcacg
    19021 tgcacttcgt caccgggcag aacctccggg gcgtcgaact gatcgaccgg agcctcgccc
    19081 tggtcgacga cccggtgcac cgcggcacgc tgctgagcaa ccgcggcctc ctgctgtccc
    19141 acctcgggcg cgtccaagag gccgtgacca gcctggagga ggcgctcgac ctcgccgtcc
    19201 ggaccggcga cctgcgcagc gaggccaccg tgctcagcgc gctcggcaac ctggtggagg
    19261 ccgaggaccc gcacctggcc atcgcccacc accggcgcag cgtcgaggcc ggccggcgct
    19321 gcgacttcgg cgacgcggtc tgcgcgggcc tggccaacat cggcttcgcc cacctgcggc
    19381 tggacgaccc cgccaccgcg ctggactact tcgcccgggc caccgccccc tccccgtggg
    19441 tcgtcccctg gcacgtcgcg ctggagaacg ggcgcggcca ggccgaggcg ctgcgccggg
    19501 tcggccggcc ggccgaggcc ctggagctgg tccgcggcct gctcgaacag gccaccgccc
    19561 tccaggacgc cttcgcggcc ggcaccatcg agcacaccca cggcctggtc ctgcgcgacc
    19621 tcggccgcct cgccgaggcc cgcaccgcct ggcgcgccgc cctggagcgg ctcggcgcct
    19681 cgggccacaa ggcggtcgcc gaactgcacg agctgctcgc ggcggggtga gcggcggcgg
    19741 tccgccgccg cggtgtgacg gatcgtcagg aggcggcgcg tccggtggag cggcccccgt
    19801 ggtgcgcccg tggagccccc tgtcgggttc gaaccgacga ccccctgttt acaagacagg
    19861 tgctctggcc aactgagcta aggaggcgcg gtggccgtcc gcgcgatcca cggcggcacc
    19921 agtgggcagt gtaccgggca ggggcccgga ggtgcgggtg gttgtggggg cgcggaggag
    19981 ggtcgtggag gagcggtgtg accggatcga tgcgaactcg ggggcggtgg agggctgaca
    20041 aaacgatgaa ctgccaggta gcgtcacggg cagccgtgct cgactgccgt ggtcaagacc
    20101 agtcgggagc ggtggaaaac atccaccttt actcggatcg tccggcacgt tcctgccggt
    20161 gaaggagcga agcaccatgg cttctgtgac gtacgacaag gcttcccgtg tgtacccggg
    20221 tgccgacaag ccctccgtcg accagctgga cctggagatc gcggacggcg agttcctcgt
    20281 cctcgtcggc ccctccggct gtggcaagtc gacctcgctg cgcatgctgg ccggcctgga
    20341 ggacgtgaac gagggcgcca tccgcatcgg cgaccgcgac gtcacccacc tgccgccgaa
    20401 ggaccgggac atcgccatgg tgttccagaa ctacgcgctg tacccgcaca tgaccgtcgc
    20461 cgagaacatg ggcttcgccc tgaagatcgc cggcgtgaac aaggccgaga tccgcaccaa
    20521 ggtcgaagag gccgccaaga tcctcgacct gacccagtac ctggaccgca agccgaaggc
    20581 gctctccggc ggtcagcgcc agcgcgtcgc gatgggccgc gcgatcgtcc gccagccgca
    20641 ggtcttcctg atggacgagc cgctgtcgaa cctggacgcc aagctccgcg tgtccacccg
    20701 cacccagatc gcctcgctgc agcgccgcct gggcatcacc acggtctacg tcacccacga
    20761 ccagaccgag gccatgacca tgggtgaccg cgtcgcggtc ctcaaggacg gcatcctgca
    20821 gcaggtcgac gccccgcgcg ccatgtacga ccgcccgggc aacctgttcg tggccggctt
    20881 catcggctcc ccggcgatga acctcatcga ggttccgctg gtcgacggcg gcgtgaagtt
    20941 cggcggctcg atcatcaaca tcgcccgcga ggacctcgcc aaggccggcg acgcgaagag
    21001 cg
//
