LOCUS       NZ_CP054916            25198 bp    DNA     linear   CON 31-JUL-2024
DEFINITION  Streptomyces sp. NA02950 chromosome, complete genome.
ACCESSION   NZ_CP054916
VERSION     NZ_CP054916.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. NA02950
  ORGANISM  Streptomyces sp. NA02950
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9619720)
  AUTHORS   Zhang,B., Shi,J. and Ge,H.
  TITLE     Genome mining for natural products
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9619720)
  AUTHORS   Zhang,B., Shi,J. and Ge,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2020) Institute of Functional Biomolecules, State
            Key Laboratory of Pharmaceutical Biotechnology, Nanjing University,
            No.163 Xianlin Avenue, Nanjing, Jiangsu 210046, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. v2.05
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013364155.1-RS_2024_07_31
            Annotation Date                   :: 07/31/2024 07:40:21
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,566
            CDSs (total)                      :: 8,476
            Genes (coding)                    :: 8,147
            CDSs (with protein)               :: 8,147
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 329
            CDSs (without protein)            :: 329
            Pseudo Genes (ambiguous residues) :: 0 of 329
            Pseudo Genes (frameshifted)       :: 152 of 329
            Pseudo Genes (incomplete)         :: 270 of 329
            Pseudo Genes (internal stop)      :: 20 of 329
            Pseudo Genes (multiple problems)  :: 101 of 329
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:05:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7455491
            Orig. end                         :: 7480689
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP054916.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25198
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="30"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25198
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25198
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15198](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15198)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    384..397
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.73"
                     /tool="antismash"
     tRNA            555..631
                     /anticodon=(pos:7456080..7456082,aa:Pro,seq:ggg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUT19_RS32775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUT19_32775"
                     /product="tRNA-Pro"
     gene            555..631
                     /locus_tag="HUT19_RS32775"
                     /old_locus_tag="HUT19_32775"
     gene            1681..4983
                     /locus_tag="HUT19_RS32780"
                     /old_locus_tag="HUT19_32780"
     CDS             1681..4983
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955268.1"
                     /locus_tag="HUT19_RS32780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32780"
                     /product="type ISP restriction/modification enzyme"
                     /protein_id="WP_254885899.1"
                     /transl_table=11
                     /translation="MTQEQFGWLSEAISTFGASCKDMVNGPGDPEASIRPPMQKLLETV
                     GSHDALDGVLWHSETPLRDVGVRPDYAVEVHGDIVGYIEVKRPGHPVDPEKFTGRNKKQ
                     WERLRDLPNVLYTNGTEWRLFRTGEQIGTPVVFEGDLASAGRSLTAREPAAFNSLLRTF
                     LHWVPEPIRQASALVRRTAPLCRLLRAAVLEQLEFEGRYAAEGARPEELRFTGLKNDWR
                     KLLFPTADDATFADGYAQAVTFALLLARTEDISLKGVGLHEVGRRLDAGHALMGKALQL
                     LTDNITVSFEVSLDLLIQVIDAVDWAAIRKGRRDAYLHLYESFLEVYDEKLRQKSGSYY
                     TPREVVEEMVRLTEDVLRTRLGLSDGYADESVRIVDPAMGTGTYLHTVIEHVAAWAAEN
                     IGPGATPDAIGDLAKRLIGFELQMGPFAVAELRTSDLLKRHQAVAPPDGMKLFVTDTLD
                     DPYLAEETLASTYGVISESRKRANRVKASTPVTVAIGNPPYDDKAKGRGGWVEKGTPAQ
                     GVAPIEAFKWPGNGRYEHVLKNLYVYFWRWATWKVFDAHPQDQQGVVCFITPSGFTTGP
                     GGRGMRDYLRRTCDEGWIIDLSPEGHRPDVASRIFPGVAQPLAICVFVRSKDTDPERPA
                     RIHYRAVHGKRGVKYRQLKEIRLDDDGWQDTHSDAIRPFRPTTETGWEDYPALHDLFCW
                     GSLGITANRSWVNGPSRQVLEKRWARLIHENDPAKKAELLKETRDRSLHASRDPLPGQP
                     KHTQELADETDLAPDLVRIAMRSFDRQWLISDSRVIDFARPALWEAMQPDQLFLNQQSS
                     HEIETGPAIVATSLLPDTHHFNGRGGKVMPILHPDGTPNVHPRLLAYLAAELGLDHVTV
                     HDLAAYAAAVAGHAGFTKRFTEELLTPGVRLPLTRDSALWYEAVQLGKRLLWASTYGER
                     YVDPEDGRPAGDVLFPLGDARRLRYDQHIGAEVPAEIRYAELTGTLHLGGGHVSPVPAE
                     VWNYDVGGMQIVKKWFGYRKANPNSRKTSPLDDLHVESWPADWSRELRELLSVLRRLVD
                     LAPTQQGLLDRVLAAPTITTIDLEKVGILPVADKARKPHRRVVLPTEAGEEA"
     misc_feature    2122..2124
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4991..5290)
                     /locus_tag="HUT19_RS32785"
                     /old_locus_tag="HUT19_32785"
     CDS             complement(4991..5290)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT19_RS32785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT19_32785"
                     /product="hypothetical protein"
                     /protein_id="WP_176183919.1"
                     /transl_table=11
                     /translation="MAVRDLEEASIADDVRTLSWMGLVETRGERLAITPRGRAVHFEAE
                     CAVLSARLAEVSVFADALQRRTPSLGAELHALRQLADGAWSVTEAVAYVERCAH"
     misc_feature    5815..5829
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.43"
                     /tool="antismash"
     gene            5990..7291
                     /locus_tag="HUT19_RS32790"
                     /old_locus_tag="HUT19_32790"
     CDS             5990..7291
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="HUT19_RS32790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32790"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_176183920.1"
                     /transl_table=11
                     /translation="MTERTIHLVADASSRDTRKFRVRALRWFATVQLDRDNYVDAESSR
                     GSEPTLPADYIEAVNRARYAAIDRIRYDGYQGSFYFGNGPRWIDLCARFRDVEATVEAL
                     RAAELEHNYSGLHVLADRLALPVDEWLGPGERELIRGVDFDSPPGVFLKFLRAKATKCG
                     LRLNGRATAGSVWVRPTLSAAQKQIREMFPEQYPGWVDRWTGYVESDDAPFRPWVGGSG
                     EDLSRGAIPVQFQQLETASSHECPCGMRLRDTGDDDNVHRVHHVAWALGVRVSKGLDWW
                     GDLAIVTTQSPISWRKLAHQVARMPQREYNYDFPSWSHLGEPEATTDNYRAYLLKVDEC
                     IIGYVAAHDTNEHRRWDLIDGSTCRDADATLRPRIILIWVADSYRHRGIGATLVQALAT
                     DFGCKVADVSWSTPVSAAGQRLARRLSPDGIWVS"
     misc_feature    6062..6064
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6140..6142
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6335..6337
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6362..6364
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6947..6949
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6992..6994
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(7543..7561)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.14"
                     /tool="antismash"
     gene            7559..7978
                     /locus_tag="HUT19_RS32795"
                     /old_locus_tag="HUT19_32795"
     CDS             7559..7978
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009086308.1"
                     /locus_tag="HUT19_RS32795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32795"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_176183921.1"
                     /transl_table=11
                     /translation="MTHTPPAWPVSVKGVALDVRGRVLLLKNERDEWELPGGRLEAADI
                     SPECTVERELQEESGWRVKAGPLLDVWIYQPLPQTRPERRVLIVTYGCTVLTPEVDPVL
                     SHEHQQIGLFTEAEVPELTMPEGYKESIATWYGRM"
     gene            complement(8252..8524)
                     /locus_tag="HUT19_RS32800"
                     /old_locus_tag="HUT19_32800"
     CDS             complement(8252..8524)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT19_RS32800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT19_32800"
                     /product="hypothetical protein"
                     /protein_id="WP_176183922.1"
                     /transl_table=11
                     /translation="MPVTPQAERFSEGDAEADPGVGEQMQDLPFGVPVFEPRFETGDQR
                     PPFDDGCGGVTALAGDFGEADRGLSELNHRPVVGVSRIGDTQDVR"
     gene            8557..8694
                     /locus_tag="HUT19_RS32805"
                     /old_locus_tag="HUT19_32805"
     CDS             8557..8694
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT19_RS32805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT19_32805"
                     /product="hypothetical protein"
                     /protein_id="WP_176183923.1"
                     /transl_table=11
                     /translation="MEEIIWPVVVLDGHRVLGVRGLEVDAGEERVAIGVPECGDDFGGA
                     "
     gene            complement(8815..9963)
                     /locus_tag="HUT19_RS32810"
                     /old_locus_tag="HUT19_32810"
     CDS             complement(8815..9963)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953653.1"
                     /locus_tag="HUT19_RS32810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32810"
                     /product="hypothetical protein"
                     /protein_id="WP_176183924.1"
                     /transl_table=11
                     /translation="MDPNGPIAQRFPLVARPRPACRPLPERVHALVDLADTAARQSDPG
                     IASTVYNQSALIASDLNIPELARDLCYQHANAYLHACPLPGKSAIRGLEPVVNLARLQI
                     RAGKTDDGRQRLLTLYEAVSTGTAAQFDTVALPAHLTATPEDRNQVRAWLWAVLLADGT
                     RTLTTKGRWDEALAHIKEHRGVGNRMLDGRQVAVLAALVAGDLARAAALLEDTAPGQPW
                     EQAVTACLIALWRRAARQPADRHPHGLADIYAELEPELGMAVFDARLGLTILDIIGSDE
                     EPVAHRVVDELHRRATTLNDGYAARENLTHPLFTALATEAQQKSCRDIVDVCALGAGKL
                     PDELRNQLAMALRTSDRTIRKSARYLYIAAPTSRADCPTGQK"
     gene            complement(10001..10882)
                     /locus_tag="HUT19_RS32815"
                     /old_locus_tag="HUT19_32815"
     CDS             complement(10001..10882)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006345938.1"
                     /locus_tag="HUT19_RS32815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32815"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_176183925.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-32, bitscore:
                     112.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNSPAWHQVNIAFPDWSRAEHTALTRLTPLLCTAEDEGAINTWF
                     LIRKIPCWRVRYLPGPDTEHDRIGRELDALTAAGHIADWTPAIYEPEVHAFGGVEGMAA
                     AHRLFHRDSRGLLTYLQGGGGAKNGHRREMSLMLGSILMRSAGLDWYEQGDVWARVAAH
                     RALPTTSDQRSSDRLQAAVHRLITVDAEDQMSEGGPLAHAAGWACAYAAAGQELAHLAA
                     SGALHRGLRNILAHHVIFAWNRIGLPYATQAALAATATTVIFGPDPTAEDGVGAVNTDT
                     TATASGPPSAPH"
     gene            complement(10901..12130)
                     /locus_tag="HUT19_RS32820"
                     /old_locus_tag="HUT19_32820"
     CDS             complement(10901..12130)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953651.1"
                     /locus_tag="HUT19_RS32820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32820"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_176183926.1"
                     /sec_met_domain="LANC_like (E-value: 1.4e-43, bitscore:
                     148.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPIPQALAAADTIVAALTDPHTAWAAASSGRAWPQSLAGGAAGI
                     ALLHIERAHTGHGDWITAHTWISRAASEDLTAASNASLYLGAPALAFVLHAAAGSTGRY
                     RNALEKLNEATIAVTRRRLAHAHARIGRGERPAMQEFDLIRGLAGLGAYHLVRQPHHEI
                     TADVLAYLVRLTDPLPEEGDLPPWWTDVSPSGESNPAFPGGHGNFGLAHGIGSVLALLS
                     LALLRGLPVPGAPEAIRRICAWTDQWRQQDDTGPWWPGLISIEQATGGHIDPALRPRPS
                     WCYGVSGTARAHQLAGLALGEPTRVQAAENAILAALRDPIQLELLPEIGLCHGTAGLLH
                     AAWRMADQTRNPAITAELPHLADRLIVALGRPDHDPELLDGAAGAALALHTIGTGIAPA
                     SHWDTFLALA"
     gene            complement(12127..15198)
                     /locus_tag="HUT19_RS32825"
                     /old_locus_tag="HUT19_32825"
     CDS             complement(12127..15198)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960873.1"
                     /locus_tag="HUT19_RS32825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32825"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_254885900.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.2e-197,
                     bitscore: 656.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.6e-12,
                     bitscore: 46.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8e-25, bitscore:
                     86.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVRVYEYVDAAMLRAVAWPPGHQVRSWPDPTGGVASWRLWLERL
                     LQMPGFAAALEQASPVLARSVWEICDGRKMPEPAVRKAVLAVMRYLLRASSRATPFGLF
                     AGVAPARIADVPTVHIGTGHRAVAKPDAAWLTAVIERLETDPALLPRLTVQAHALAVEK
                     DGHLILEHRGGGSSGGPPAHVRVRATTPVMSAMDAARRPIRAQDLASKLSADFPHVPAE
                     VIDKLLADLTAQRLLLTNLRCPITTTDALGRLLNALDAAEAENIATVANTTAQLRQIAD
                     ALARHNTTATRAREQRAQLTNAMQSLSSCSGPALGVDLRLEGEVTIPYAVATEAARAAT
                     ALVRLAHHPFLSRAWASWHSRFLERYGPRALVPILDAVDGDTGLGYPAGFLGGPPAPES
                     GPLAERDMKLLALAQNAALRRQHEIVLDDAMIADLTTAGSDMRVQPTTELTVRVHASST
                     RALGAGEFTLAITGVSRTAGTVTGRFLGLLGPGDRERMAKAYAAASAATEGALTVQISA
                     PPLHVDTENVARAPRAMPAVLAVGECHDHDDNGRVLLEDIVVTADAQRLYLISRTRHRP
                     LEFVTLNAVEPVHRTHPLVRFLTEVTNAMSVPCTTFDWGAATNLPFLPALRYRRTILSP
                     ARWLLTAAELAAREADGAQWDRSLAAWRDQVAAPSTVYAGDGDQRIRLDLTEPAHRALL
                     RAQVQRDGAAVLRAETAADAGWIGGRAHELVIPLAVGGEPQRAPQWLDGGQSVGREHGH
                     LPGCDGRFLIKLYGRPDRFGSILTRHLPGLLTELDSRARWWFLPYRDPDDHLRLRLVVP
                     TDRATSTPAAIGAWARRLRQAGLISRVQWDTDFPETARFGGTLAIDAVEAYFAADSEAA
                     VAQIACSVTKGSPDTRALTAASLLDLTTSLIGNPAEAMTWLIDHARTTSTAPARALYDQ
                     AVTLGNPHGHGHLARQPGGERIVARWAQRREALAAYKAVLDTASTARATTLLPELLHLH
                     HTRISGLDLDAERQCLHLARAAALSWTARGRSGS"
     aSDomain        complement(14470..14733)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HUT19_RS32825_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="8.80E-15"
                     /identifier="RREFam001.1"
                     /label="HUT19_RS32825"
                     /locus_tag="HUT19_RS32825"
                     /protein_end="243"
                     /protein_start="155"
                     /score="46.2"
                     /tool="antismash"
                     /translation="AHALAVEKDGHLILEHRGGGSSGGPPAHVRVRATTPVMSAMDAAR
                     RPIRAQDLASKLSADFPHVPAEVIDKLLADLTAQRLLLTNLRC"
     misc_feature    complement(15034..15036)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15261..15485)
                     /locus_tag="HUT19_RS32830"
                     /old_locus_tag="HUT19_32830"
     CDS             complement(15261..15485)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009322874.1"
                     /locus_tag="HUT19_RS32830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32830"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_254885901.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.4e-17, bitscore:
                     60.6, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTTQLIREVFVSVQFEDAAAPSAPPVTSHEGDFEGWDLDVSIVE
                     SGPSADRLIRMTDDGCGQTCQSACSTTCP"
     CDS_motif       complement(15333..15485)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRTTQLIREVFVSVQFEDAAAPSAPPVTSHEGDFEGWDLDVSIVESGPSAD"
                     /locus_tag="HUT19_RS32830_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15261..15332)
                     /prepeptide="core"
                     /locus_tag="HUT19_RS32830_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-1.90"
                     /molecular_weight="2339.6"
                     /monoisotopic_mass="2338.0"
                     /core_sequence="RLIRMTDDGCGQTCQSACSTTCP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRTTQLIREVFVSVQFEDAAAPSAPPVTSHEGDFEGWDLDV
                     SIVESGPSAD"
                     /leader_location="[15332:15485](-)"
                     /alternative_weights="2357.7"
                     /alternative_weights="2375.7"
     gene            complement(15525..16712)
                     /gene="fxlM"
                     /locus_tag="HUT19_RS32835"
                     /old_locus_tag="HUT19_32835"
     CDS             complement(15525..16712)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953648.1"
                     /locus_tag="HUT19_RS32835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32835"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_254885902.1"
                     /sec_met_domain="PCMT (E-value: 1.4e-42, bitscore: 144.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDEAASLRAAMVRELHDLGAITSETLAGAVATVPRHLFAVDEPL
                     KAAYAADQALVIKRDQDGTALSSLSATHIQVVMLEQAEIEPGMRVLEVGSGGYNAALIA
                     ELVGDTGAVVSVDIDAEIVERARTCLDAAGYEQVEVVQSDADAGVPEHAPFDRIIVTAG
                     AWDIPSAWLDQLSEHGRIVVPLRMRGLTRSIAFDRADEGLVSDSYRLCGFVAMQGAGAY
                     TERLIRVADGIGLRVDDQRQDFDINGLAAAVRSPGLEVWSGAAFDLPDELELFLATSTP
                     EMAMLHGSKDLVEQGVFALSVTRGVPALVVGGSFAYRTKRPNQETGGFESGVFAHGPDA
                     EAVAARYIDLLRRWASEHQRRGAARIRYRPMPSGTAKPSQGIVAKQLGAVEISWS"
     misc_feature    17035..17044
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    17098..17112
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     gene            complement(17247..17741)
                     /locus_tag="HUT19_RS32840"
                     /old_locus_tag="HUT19_32840"
     CDS             complement(17247..17741)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019433336.1"
                     /locus_tag="HUT19_RS32840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32840"
                     /product="RpiB/LacA/LacB family sugar-phosphate isomerase"
                     /protein_id="WP_176183928.1"
                     /transl_table=11
                     /translation="MSGLHALLRIAVGADPAGRQYASTLTGDLCAHPLVDFVIDVNDSG
                     DPPPAYPEVALAAAQLVAEGLADRALLVCHTGLGMAIAANKVHGIRAVTAHDLLSVQAS
                     VECNNAQVLTLGQGVVGITAARRLVAAWVTFRCDFTAPAAAKVSVITEYENRASRPAAT
                     R"
     misc_feature    17877..17890
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            complement(17916..18386)
                     /locus_tag="HUT19_RS32845"
                     /old_locus_tag="HUT19_32845"
     CDS             complement(17916..18386)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571585.1"
                     /locus_tag="HUT19_RS32845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32845"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_254885903.1"
                     /transl_table=11
                     /translation="MTQAVTNPAARLSPREQQIFEYLADGSSLAEVGLRLGIRQNTVQS
                     YLSLAKLKLGAKSENAAALAAAYALGGLPQPKPLDPSELSLPREQLALVPLLAQGMRVS
                     QMASVLKRPVSIIRRDARGLMKNLRARNAAQTVKRTWQYQLLTADQVLEWLT"
     gene            complement(18714..19169)
                     /locus_tag="HUT19_RS32850"
                     /old_locus_tag="HUT19_32850"
     CDS             complement(18714..19169)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUT19_RS32850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUT19_32850"
                     /product="hypothetical protein"
                     /protein_id="WP_176183929.1"
                     /transl_table=11
                     /translation="MTLPRGYWCQVIYTEPNRSDAVVLSMTTGFPGRAITWLRTTAPNI
                     AVDMDREAFGTVWAWLGDHQGASKAVRELHSGRPYTVGLGRSERPVWLLAHPVPCLPLA
                     STCIGVYQHDSSDLSRAPALRGRVVSPSRCPMTGGPHDHPDHYAPVE"
     gene            complement(19166..19537)
                     /locus_tag="HUT19_RS32855"
                     /old_locus_tag="HUT19_32855"
     CDS             complement(19166..19537)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039764.3"
                     /locus_tag="HUT19_RS32855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32855"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_176183930.1"
                     /transl_table=11
                     /translation="MAALHNSFIHEEGIDDDLDTAFGLQSALLTVEDVHELAPRIRRHL
                     RQLLNIAVQRAAGVPIPELTVIVSRAQQLEVSPPPADLAAGRGYVRRLALAAEDVLDVL
                     TAKVTDITGPVYVEERSSA"
     gene            complement(20097..20432)
                     /locus_tag="HUT19_RS32860"
                     /old_locus_tag="HUT19_32860"
     CDS             complement(20097..20432)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447317.1"
                     /locus_tag="HUT19_RS32860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32860"
                     /product="ATP-binding protein"
                     /protein_id="WP_176183931.1"
                     /transl_table=11
                     /translation="MRSLTRTRLNQSGLSSLADDAALVVSELVTNAVQHSHGREITLTL
                     SLRDGHLHIRVHDGMNSRLPIVSKPDAHAENGRGLWVVESIANQRHGSWGNSDNDAIWC
                     DLTLEVS"
     misc_feature    20732..20747
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.72"
                     /tool="antismash"
     gene            21044..22369
                     /locus_tag="HUT19_RS32865"
                     /old_locus_tag="HUT19_32865"
     CDS             21044..22369
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010263902.1"
                     /locus_tag="HUT19_RS32865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32865"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_368661719.1"
                     /transl_table=11
                     /translation="MLRLVRKRSGLSQMAVRELTALPQSFISGLERGQKQIGSPATLLD
                     LLNGLGLPSDLQPLLLTPLRGDAPKPGHSRSAEAVLPWTADRMVTSLEVAIGGTAMKRR
                     RVLTALSGAALTQYVMQSAIAPAEAMAASSGTTTVTDALIDSLQGTTDALRQVDATSGS
                     GSLAYTAKTHLRMLLNLLKQGSYTENHGRRLAAVTADTAAQTGWYTFDSGDHDTAQHFF
                     LGALRAAHASGDSRLHAGALGFLAIHGYSVGDPRDAVTAARTARQAITDHDAPALNAML
                     LTRQARGHARLREERYALAALAEAEELCARGRGADDPHWLYWINSGEILGQTGSCYLDL
                     GQPARAAQSFAAARDVLSRDETRTTAQFLSRAATAQMRAADADAGCATAHDVLTLAEGI
                     QSARLDDHLRSMLNEARSYGASSLARDLLERGASIMRQRAAA"
     misc_feature    21074..21076
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            22366..23115
                     /locus_tag="HUT19_RS32870"
                     /old_locus_tag="HUT19_32870"
     CDS             22366..23115
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549551.1"
                     /locus_tag="HUT19_RS32870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32870"
                     /product="HAD family hydrolase"
                     /protein_id="WP_176183933.1"
                     /sec_met_domain="HAD_2 (E-value: 2.5e-07, bitscore: 29.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILVLWDIDRTLLYTGDTDRLVYRELFEEVVGRPAESLPARGTGV
                     TMPLAVRELLRVNAVEPELIEELAQRIVQRMPAQLERHRDELSRTGQVMPSAPAALAAV
                     QLEPGLVPTVVTGNLRGSAEIKLKALGLDEYLDLSIGGYASDDAHRPALVRVAQQRAGT
                     RHAYTFTRDTTVIIGDSLEDVRTGREGGATVVGVASGTASAEKLAAAGACHVVPDLTDV
                     QRVIRLINQCAASDVDQGCPEPPQDAM"
     gene            complement(23004..23447)
                     /locus_tag="HUT19_RS32875"
                     /old_locus_tag="HUT19_32875"
     CDS             complement(23004..23447)
                     /EC_number="2.7.1.121"
                     /GO_function="GO:0004371 - glycerone kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006071 - glycerol metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014753.4"
                     /locus_tag="HUT19_RS32875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32875"
                     /product="dihydroxyacetone kinase subunit DhaK"
                     /protein_id="WP_176183934.1"
                     /transl_table=11
                     /translation="MKRILNSSDNVVEDMLSGISEAHSDIVRVDLTQRLCLHRAPLPAG
                     QVAVISGGDSGHKSLHAGFVGEDMLTAAVLGDIFASPSAYQTGGVLNDAEVAHLLAGPH
                     LDHLNSSYIASCGGSGQPWSTSEAAHWLIRRITRCTSVRSGTT"
     misc_feature    complement(23417..23431)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.66"
                     /tool="antismash"
     misc_feature    23430..23445
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.38"
                     /tool="antismash"
     misc_feature    complement(23433..23448)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.2"
                     /tool="antismash"
     misc_feature    23446..23460
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.98"
                     /tool="antismash"
     misc_feature    23873..23889
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     misc_feature    23957..23972
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            24003..24470
                     /locus_tag="HUT19_RS32880"
                     /old_locus_tag="HUT19_32880"
     CDS             24003..24470
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="HUT19_RS32880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUT19_32880"
                     /product="ATP-binding protein"
                     /protein_id="WP_176183935.1"
                     /transl_table=11
                     /translation="MIGAAGEGQASVWRWNSRSGDAAVSARVALRSALAQLGLPDGAVC
                     DVTRAAWELTANAMEHACGPYEMRLQRKGASLVFEIEDGDPRIPATPPAVPSGGEFEVD
                     GDDLDSLIASLSEDGRGLRIVDQITGGQWGFRPSRSGIKAAWMVISDPPKG"
     misc_feature    complement(24708..24724)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.71"
                     /tool="antismash"
ORIGIN
        1 ctacgaggaa ctcggcctga tccactccca gcgcaccacc ggccgccagc gccgcttcgc
       61 ccgctccacc cttcggcgcg tcgccttcat ccgggccgcc cagcaggtcg gcctctccct
      121 cgacgaaacc cgcgccgccc tcgaccgcct ccccgccgac cgcgccccca acgccaccca
      181 gtggaacgcc gtcgcgcgca cctggtccca ccgcatcgac cagcagatcg ccgacctgga
      241 acggctgaag cgcagactca ccggctgcat cggctgtggc tgtctgtccc tgcgcaaatg
      301 ctccctctac aacccctccg acaccgcctc cacccacggc ccaggtgccc gctacctcct
      361 cggcgacgaa ttgccaccat ccgaccaccc agcgtgaccc ttgctgggta cgcccacccc
      421 gccacccccg ccgagccgcc gcccacctgg cggagatcca tcgcctgtcc ccgggtggca
      481 gcgaccaccc cctgaagtgc ggtattgttc tcgtgcgcgg tcggcgaggg cgagatccca
      541 tgccgaacaa gcaccgggac gtggcgcagt ttggtagcgc acttgactgg gggtcaaggg
      601 gtcgcaggtt caaatcctgt cgtcccgacc agcgtttttg caggtcggag gccgtttccg
      661 cgggtagcgg aagcggcctt tgtcgttccc ggactgggag cgatggggag ccctctggga
      721 gccctcgtgc tcccaactcg cagatgggtc aatcccgtcc ggtttgtccg tcgcccgatc
      781 cggtcgacct gtcgcgcggt accgcgccac cgggcgccgt cgtcaaccgt aggtcgccga
      841 ggtcaccccg ccggtatgga tgctctcgcc atcgagaggc ataagaaccc cttgacggtt
      901 tccgacctcc tttcggagtg ggagcccggc ttcctgctcc ccatgcggca ggggaggccc
      961 gaccacgctg gcgacgctgg gcagcccgtc ttggcaggcc cgtgatcact cgggctctcc
     1021 ggtcgcctga tgcttgccgc gccaaggtgg ggcaaagccc ctttgcgctg ggcggcggac
     1081 ggggcactcc cagggcgtga gcgcggtagt cggctctgta gcgccgtagt gagacatccg
     1141 ggagaggctt caggggaggc aaaatagtgt gccaagcaat tccgatgaga ggtcgatggg
     1201 gtggcgtcag gacgcatcac ttgcacggtg gggcgttcgt gcgttcttgc tgactgaggg
     1261 gtgggcgcag ttggggaagt aggtatggca tgtggtggag ttccggcggt gtgtcggtgg
     1321 gtgtgtcgca cgagcccgcg ctcgctacgg ctgagcccct gcgctgaccg caaaaagctt
     1381 cgggcatccg gtgctctcga tgtggcagac cggcatcgtc tactacgggc tgaacctagt
     1441 ggactacatg caccgaaagg tcgacgaggc acggggcggc gtcgacgaga gctgggaccc
     1501 aagggcaacg gttccgttct ggcgacctcg cctgatcctc tacgtctgcg cggagcgtcg
     1561 accgagccat actccaagct cttccctcaa cttcgtaagc tgcgctggga cttcgtttcg
     1621 ctcttcttgc ggacctgaca tactatcaag tcgtgatcgg cagtgcgtgg gggtgcaaca
     1681 ttgacgcagg agcagttcgg ctggctctcg gaagccatat cgaccttcgg tgcgtcgtgc
     1741 aaggacatgg tgaacggacc gggcgacccc gaggcgtcca tccgcccgcc gatgcagaag
     1801 ctcctagaga ctgtgggcag tcacgatgcc ttggacggcg ttctgtggca ctcggaaacg
     1861 cccctgcgtg atgtaggtgt gcgccccgac tatgcggtcg aggtacacgg cgacatcgtc
     1921 ggttacatcg aggtcaagcg ccccggtcat cctgttgatc cggagaagtt cacggggcgt
     1981 aacaagaagc agtgggagcg actgcgcgac ctgccgaacg tgctctacac caacggcacg
     2041 gagtggcggc ttttccgcac cggggagcag atcggcactc cggtcgtctt cgagggcgac
     2101 ttggccagtg caggacggtc gttaaccgcc cgtgagcctg cagcgttcaa cagcctcctg
     2161 cggaccttcc tgcactgggt tcccgagcca atccgccaag cctccgctct ggttcggcgc
     2221 actgcgccgc tgtgccgcct cctgcgcgcg gcggtcctgg agcaactgga gttcgagggg
     2281 cggtatgcgg cggagggcgc gcgtcctgag gagttgcggt tcacggggct gaagaacgac
     2341 tggcgcaagc tgctctttcc gacggccgat gatgccacct tcgccgacgg ttatgcccag
     2401 gcagtgactt tcgctctgct gctggcacgc accgaggaca tctccttgaa gggggtgggg
     2461 ctgcatgagg tcggtcggcg gctggatgcc ggacatgcct tgatgggcaa agcccttcag
     2521 ctcctcaccg acaacatcac ggtgagcttc gaggtcagcc tcgatctgct gattcaggtg
     2581 attgacgcgg ttgactgggc ggcgattcgt aagggccggc gggatgcata tctgcacctg
     2641 tacgagtcgt tcctggaggt gtacgacgag aagctgcggc agaagagcgg ctcgtactac
     2701 accccgcgcg aagtggttga ggagatggtg cgcctcaccg aggacgtgct gcgtacccgc
     2761 ttgggcctct cggacggata tgcggacgag agcgtgcgca tcgtcgatcc agcgatgggg
     2821 acgggcacct accttcacac ggtcattgag catgtcgccg cgtgggcggc ggagaacatc
     2881 ggccctggtg caacgccgga tgcgataggt gatctggcga agcgtctgat tgggttcgag
     2941 ctgcagatgg ggccctttgc tgtcgccgag ctgcggacgt cggatctact taagcggcat
     3001 caagcggtcg caccgccgga tgggatgaag ctgttcgtca ccgatacgtt ggacgaccct
     3061 tatctggccg aggaaaccct cgcctcgacg tatggggtga tctcggagtc ccgtaaacgg
     3121 gcgaaccggg tgaaggccag cacgccagtc accgtggcga tcggcaaccc tccctacgac
     3181 gacaaggcca agggccgcgg cggctgggtc gagaagggca cacccgcgca gggcgtggct
     3241 cccatcgagg ctttcaagtg gcctggcaac gggcgctatg agcacgtgct gaagaacctc
     3301 tacgtctact tctggcgctg ggcgacgtgg aaggtcttcg acgcccatcc acaggatcag
     3361 cagggagtcg tctgcttcat tacgccctct ggcttcacca ctgggcccgg cgggcgtggc
     3421 atgcgggact acctgcggcg cacctgtgac gagggctgga tcatcgacct gtctccagaa
     3481 gggcaccgcc cggatgtggc cagccggatt ttcccgggtg tcgcccagcc gctggccatc
     3541 tgcgtttttg tccgcagtaa agacaccgac cctgagcgac ccgcccgtat ccattaccgc
     3601 gccgtacacg gcaagcgagg cgtcaagtac cgccagctca aggagatccg actggacgac
     3661 gacggctggc aggacacgca ctcggatgcc atccgcccct tccgtcccac cactgagacg
     3721 gggtgggagg attaccctgc tctccacgat ctcttctgct gggggagcct gggcatcact
     3781 gccaatcggt cctgggtcaa cggccccagc aggcaggtgc ttgagaagcg atgggcgcgt
     3841 ctgatccacg aaaacgatcc ggccaagaag gcggagctgc tcaaggagac aagggaccgt
     3901 tcgctgcacg ccagcaggga tccgttgccc gggcagccta agcacaccca ggagctcgcg
     3961 gacgaaacag acctggcacc tgacctggtg cgtatcgcca tgcgaagctt cgaccggcag
     4021 tggctgatct ctgatagccg tgtcatcgac ttcgcccggc ctgcattgtg ggaagccatg
     4081 cagccagatc agctcttcct gaaccagcag tcctcgcacg agatcgaaac cgggccggcg
     4141 atcgtcgcta cctccctgct ccctgacacc caccatttca acggccgtgg tggcaaggtc
     4201 atgccgatcc tccatccgga cggtaccccc aacgtgcatc cacgcctcct cgcgtacctc
     4261 gccgccgaac ttggccttga ccacgtcacg gtgcacgatc tggctgcata cgcggcggct
     4321 gttgccgggc acgccgggtt caccaagcgg ttcaccgagg agctcctcac cccgggcgtg
     4381 cggctgccgc tcacccgcga ttccgccctg tggtacgaag cggtgcaact gggcaaacgc
     4441 ctcttgtggg cctcgacgta cggggagcgc tatgtcgatc cagaagatgg ccgaccggcc
     4501 ggagacgtcc tctttccgct aggcgatgcg cgtcggctcc gttacgacca gcacataggg
     4561 gcggaagtcc ccgccgaaat ccggtacgcc gagttgaccg gcaccctgca cttgggcggc
     4621 gggcacgtca gccctgtccc cgccgaggta tggaactacg acgtcggcgg catgcagatc
     4681 gtcaagaaat ggttcggcta ccgaaaagcc aaccccaaca gccgcaagac cagccccttg
     4741 gacgacctgc atgtcgagtc ctggccagct gactggtcgc gggagctcag agaactgctc
     4801 tccgtgctgc gccgacttgt tgacctcgcg cccacccagc agggcctgct ggaccgcgtc
     4861 ctcgccgctc ccactattac tacaatcgac cttgagaagg tcggcatcct gccggtcgcc
     4921 gacaaggccc gcaaacctca ccgccgagtc gtactcccca ctgaggccgg cgaggaggcg
     4981 tagagcctgg tcagtgggca cagcgctcca cgtatgccac cgcctccgtc acgctccatg
     5041 ccccgtcggc gagttggcgg agcgcgtgta gttctgcacc gagagagggt gtgcgtcgct
     5101 ggagggcgtc ggcgaagacg ctcacctcgg ccaggcgcgc cgagagcacg gcgcactcgg
     5161 cttcgaagtg cactgcccgt ccgcgcggcg tgatggccag gcgctcaccc cgggtctcca
     5221 ccagtcccat ccagctgaga gttcgcacgt cgtccgcgat gctcgcttct tcgaggtctc
     5281 ggacagccac cgccatggga tccgtatcgg ggtgtggaac ctcggcgagc atgaggtgtt
     5341 gcagaagttg aagctgcgaa ggggagagag ctgagtgcac ggttgcatgt ctagcagcac
     5401 agggggtcag tcccgtgcat cagggccgag ttcgacccaa cttccacctg aatcagatca
     5461 gtatccccgg gttgctcggg gctctgtgcg cacggcccgt ctgtgaaggc gccgcccacc
     5521 aacggctacc cgcctgcgct cgtgcccccc ttcttttgct gtgaagaggg cgcgccttgg
     5581 accgcaggcg ctctgcgcga tcggatggag cgggcgggcc gctcttgacc aggcagggaa
     5641 gttccgtccc cgctgctgca gccaagatcg gaagtcgcct ctggtgcctg cgccgagagg
     5701 tcggcttcgc cgactggctg caacaccctg ggtgttgcag ccgtctgtga ccggacagcc
     5761 cggacacctc ccgcgcgggg gccggcatta cagtgattgc gtcgaacaag acctccgcta
     5821 cttctgggct gggagggaac tcaatccggg ggcacggcgt cggcggtgtg gcgggggcgt
     5881 gccgcacgac ggacagcatg gacacttcca gatccgtgct cttcccgagg gttgcacagg
     5941 caggaatgat gggtctgacc gatccggcta gagccatgga gtagaatgca tgaccgagcg
     6001 gactatccac cttgtcgctg atgcaagcag tcgggatacc cggaagttcc gagtccgggc
     6061 attacgctgg ttcgccaccg ttcagctcga ccgagataac tacgtcgatg ccgaatcctc
     6121 acggggcagc gaaccaactt tacctgcgga ctacatcgag gcagtcaaca gggcgcgcta
     6181 tgcggcgata gaccgcattc gatatgacgg ttaccaaggc tccttttact tcgggaacgg
     6241 tcctcgctgg atcgatttgt gcgctaggtt ccgagacgtc gaggctacgg tcgaagcatt
     6301 gcgcgctgct gagctcgaac acaattacag cggattacac gtactcgccg accgcctcgc
     6361 attacccgtc gatgaatggc tcggtcctgg tgagcgagag ctgatccgcg gagtcgactt
     6421 cgattcaccc cccggggtgt tcttgaagtt cctgcgagcc aaggcaacga agtgcggtct
     6481 gcgcctcaac ggtcgggcga cggctggcag tgtgtgggtt cgccccacac tgtcagcggc
     6541 tcagaaacag attcgtgaga tgttccccga gcaatatccg gggtgggtgg accgctggac
     6601 tggttacgtc gagtcggatg atgcaccctt ccggccttgg gtgggaggta gtggcgagga
     6661 tcttagccgc ggcgcgatac cagtccaatt ccagcagttg gagaccgcga gtagccatga
     6721 gtgcccctgc ggcatgcgac ttcgggatac gggggatgat gacaacgtcc accgcgtgca
     6781 tcatgtggct tgggcgctag gcgtgcgggt gtcgaagggg cttgactggt ggggtgacct
     6841 ggcaattgtc acaacgcagt cacccatttc gtggcggaag ttggcccacc aagtggcgcg
     6901 tatgccgcag agggagtata actacgactt cccgtcgtgg tcccacttag gtgagcctga
     6961 agcgactacg gacaactatc gcgcatatct gttaaaagtg gacgagtgca tcatcggcta
     7021 cgtggccgcc cacgacacca acgagcaccg ccgttgggat ctcatcgacg gttccacgtg
     7081 cagggatgcg gacgccaccc tgcgcccccg aattatcttg atttgggtag cagatagcta
     7141 tcgacaccgt ggcattggtg ccacgctcgt acaggcactc gccactgact ttggatgcaa
     7201 ggtcgcggat gtgtcctggt cgactcccgt aagcgccgcg ggccagcgcc ttgctcgccg
     7261 actctcaccc gatggcatct gggtcagctg aacagtcctg caacactccg gagtgattgc
     7321 gcagatcaac ccaggaagag gcgctgagct gtggcggagc cgaaacgagg cagaccagta
     7381 acgcaaagtg cgtcgtgccc gacttatgga gttctgctga cgagatcgcc gcagagctcg
     7441 gccgcgtcca ctagtacaga ttgtcgactc aggtaaatcg cccaagagca gggagggttg
     7501 aacgccccgt gctacggtcc gaacactcag ggactgcccc gcactgcgag ggattctcat
     7561 gacgcacacg ccccccgcct ggcccgtctc cgtcaaaggc gtcgccctgg acgtgcgcgg
     7621 tcgggtgctg ctgctgaaga acgaacgtga cgagtgggag ctgcccggcg gccgactgga
     7681 ggcagcagat atcagccccg agtgcacggt ggagcgcgaa ctgcaggaag agtccggttg
     7741 gagggtcaag gcggggccgc tgctggacgt ctggatctac cagccgcttc cgcagacccg
     7801 cccggaacga cgcgtcctga tcgtcaccta tggctgcacg gtcctcacgc cggaagtgga
     7861 cccggtgctc agccatgagc accagcagat cggactgttc acggaggccg aggtcccgga
     7921 actcaccatg cccgaggggt ataaggagtc catcgccact tggtacgggc ggatgtaaca
     7981 ggccgtggcc gcccccgaat gtttgccggc gtcccgtccc tcggctcagc acgtggtgtg
     8041 gcactgggtc accccgcagg ccagcactat cttgggcagc ggcgatttcg gtgcgatcct
     8101 gcgcttccat cgaaccgtcc acggcctgac ccaaaccgaa ctgggagacc ttctcggcta
     8161 cgacaagacc tgcatctcgg tccttgaact ccggaagaag accttgggtg atgtgggttc
     8221 cctcccccgt gtctccgagc agttgcggct gctaccgcac atcctgggtg tcaccgatcc
     8281 ggctgacacc gaccaccggg cgatggttca gttcggacag tccacggtcc gcctcgccga
     8341 aatcgcccgc cagagcggtc acgcctccgc agccgtcgtc gaacggtggc cgctggtcgc
     8401 ccgtctcgaa gcgcggctcg aagacgggca caccgaacgg gaggtcctgc atctgctcgc
     8461 ccacgcccgg gtcggcctcg gcgtcgccct cggagaaacg ttctgcctga ggagtgaccg
     8521 gcatgctgtg ggtagtgggt gtagcgctcg gcggagatgg aggagatcat ctggccggtc
     8581 gtcgtgcttg atgggcaccg cgtcctcggc gtacgcggcc ttgaagtcga cgccggggag
     8641 gaacgggtgg ctatcggtgt cccggaatgc ggcgatgact tcgggggtgc gtaggtgcgt
     8701 aggcgcgttg gctgcttccc cttcgccgaa ggcgacttgg tcgcccagcc atgcggcagt
     8761 ggcctgctcg ccagaaggcg ctccgaggcg gttgaaagcg aaggccgacc gtgatcattt
     8821 ttgcccagtt ggacaatccg ctctggatgt gggcgcggct atgtacaggt agcgagcgct
     8881 tttccggatc gtgcggtcgc tcgtccgcag cgccatggcg agttggttac gcagctcgtc
     8941 agggagcttt ccagctccga gtgcgcacac gtccacgatg tcgcggcaac tcttctgctg
     9001 tgcctcagtg gcgagagcgg tgaacaaggg gtgggtcagg ttctcgcggg cggcatatcc
     9061 atcgttcagt gttgtcgcac ggcggtgcag ttcgtcgacg acgcggtgcg cgacgggctc
     9121 ctcgtcgctg ccgatgatat ccaagatcgt cagtccgagg cgtgcgtcga agacggccat
     9181 gccgagttcg ggctccagct cggcgtagat gtctgccagg ccgtgcgggt ggcggtcggc
     9241 cggctgcctg gcggcgcgac gccatagcgc gatgaggcac gctgtcacgg cttgctccca
     9301 tggttggccg ggagcggtgt cttcaaggag agctgcggcg cgggcgaggt cgcctgcgac
     9361 aagggcggcg aggaccgcga cttgtcgtcc atcgagcatc cggttgccca cgccgcggtg
     9421 ttccttgatg tgggcaagcg cctcgtccca gcgtcccttg gtggtgaggg ttcgcgtgcc
     9481 atcggcgagg aggaccgccc acagccaagc tcggacctgg ttgcggtctt ccggtgtcgc
     9541 ggtgaggtgc gcggggaggg cgacggtatc gaattgtgcg gccgtgcccg tgctgacggc
     9601 ttcgtacagg gtgaggaggc gttgtcggcc gtcgtcggtc ttccctgcgc ggatctgcaa
     9661 gcgggccagg ttgacgacgg gttccagtcc tcggatggcg ctctttccgg gcagggggca
     9721 ggcgtgcagg taggcgttgg cgtgctggta acacagatcc cgagcgagtt cgggaatgtt
     9781 gaggtcggat gcgatgagag ccgactggtt gtagacggtc gaggcgattc ctgggtcgga
     9841 ctggcgcgct gcggtgtcgg caaggtcgac cagggcgtgc acgcgttcgg gcagcggtcg
     9901 gcaggcggga cgggggcggg cgacgagcgg gaagcgctgg gcgataggtc cgtttgggtc
     9961 catgggtccc cggtggtagg aggagcgggg atgacgcggt tcagtggggt gccgagggcg
    10021 ggccgctggc ggtggcggtc gtgtcggtgt tcaccgcgcc gacgccgtct tctgcggtgg
    10081 ggtcggggcc gaatatgacg gtcgtggcgg tggctgcgag ggcggcctga gtggcgtagg
    10141 gcaggccgat ccggttccag gcgaagatca cgtggtgggc caggatgttg cgcagtccgc
    10201 ggtgcagtgc tcctgaggcg gcgaggtggg ccagctcctg cccggcggcg gcgtaggcgc
    10261 aggcccatcc cgcggcatgg gccaggggcc cgccctcgct catctggtct tccgcgtcca
    10321 cggtgatcag ccggtgcacg gcggcttgca gtcggtcgga gctcctctgg tcggaggtgg
    10381 tgggcagtgc tcggtgggcg gcaacccgcg cccagacatc gccctgctcg taccagtcca
    10441 ggccggcaga acgcatcagg atgctgccca gcatgaggga catctcccga cggtgtccgt
    10501 ttttggctcc gcccccgccc tggaggtagg tcaggaggcc acggctgtcg cggtggaaga
    10561 ggcggtgggc cgctgccata ccttcgactc cgccgaaggc gtgcacttcg ggttcataga
    10621 tggccggtgt ccagtcggcg atgtgccctg cggctgtcag agcgtccagc tcccggccga
    10681 tgcggtcgtg ttcggtgtcg gggccgggca ggtagcgcac ccgccagcac gggattttac
    10741 ggatgaggaa ccacgtgttg atcgcgcctt cgtcctcggc agtgcacagg aggggggtga
    10801 ggcgggtcag agcggtgtgc tcggctcggc tccagtcggg gaaggcgatg ttgacctggt
    10861 gccacgcggg cgagttgtcc atcagacgtc tccaggatga tcaagccaga gcgagaaagg
    10921 tgtcccagtg cgatgcgggt gcgattccgg tacctatggt gtgcagggcg agggccgctc
    10981 cagcggctcc atcgagcagt tcgggatcgt ggtcgggccg gccgagcgcg acgatcagac
    11041 ggtcggccaa gtgcggcagc tctgcagtga tcgcggggtt cctcgtctgg tcggccatcc
    11101 gccacgcggc gtggagcagt ccggccgttc cgtggcacag cccgatctcg gggagcagct
    11161 ccagttggat cgggtcgcgc agggccgcaa gaatggcgtt ctcggcggcc tgtacgcgtg
    11221 ttggctcgcc caatgccagg ccagccaact ggtgtgcgcg ggcggtgccg ctgacgccgt
    11281 agcaccagga gggccggggc cgcagagccg gatcgatatg tccgccggtc gcctgttcga
    11341 ttgagatgag acccggccac cagggtccag tgtcgtcctg ctggcgccac tggtcggtcc
    11401 acgcgcagat ccgcctgatc gcctccggtg ccccggggac ggggaggccg cgcagcagag
    11461 ctagcgagag cagggcgagg acggagccga tgccgtgggc cagcccgaag ttcccgtgtc
    11521 ctccggggaa ggccgggttc gactcgccgc tgggggacac gtcggtccac cacgggggga
    11581 ggtcgccttc ctcgggaagg ggatcggtca ggcgcaccag gtaggccagc acatcggcgg
    11641 tgatctcgtg gtgcggttgg cgtacgagat ggtaggcgcc cagcccagcg agcccgcgga
    11701 tcaggtcgaa ctcttgcatg gcggggcgtt cgcctcggcc aatgcgggcg tgagcgtggg
    11761 ccaggcgccg acgggtgact gcgatggtgg cttcgttcag tttctccagc gcgttccggt
    11821 accggccggt ggagcctgcg gcggcatgca ggacgaaggc cagggccgga gccccgaggt
    11881 agaggctggc gttggaggcg gcggtcaggt cctcggaggc tgcccgggat atccaggtgt
    11941 gcgcggtgat ccagtcgccg tggccggtgt gggctcgttc gatgtggagc agggcgatgc
    12001 ccgctgcgcc gccggccagc gattgcggcc acgctcgccc actggatgct gcggcccagg
    12061 cggtgtgcgg gtcggtcagc gccgcgacga tggtgtcggc ggcggccagc gcctgcggta
    12121 tcggtctcat gagccgcttc tccctcgtgc tgtccagctc aacgctgcgg cgcgggccag
    12181 gtgcaggcac tggcgttctg cgtccaggtc gagtccggat atgcgggtgt ggtgcagatg
    12241 cagcagttcg ggcagcagag tggtcgcgcg ggccgtgctc gccgtgtcga gcacggcctt
    12301 gtaggcggcc agcgcttcgc gccgctgggc ccagcgggcg acgatccgct cgccgccagg
    12361 ctgccgggcc agatgcccgt ggccgtgggg gttccccagg gtgaccgcct ggtcgtacag
    12421 ggcccgggcg ggagctgtgc tggtggtccg ggcgtggtcg atcagccagg tcatcgcttc
    12481 ggcggggttc ccaataaggc tggtcgtgag gtcgagcagg ctggcggcgg tcagggcccg
    12541 tgtatcggga ctgcctttcg tcacgctgca agcgatctgt gcgacggcag cctccgagtc
    12601 cgccgcgaag tacgcctcga cggcgtcgat cgccagggtg cctccgaagc gggcggtctc
    12661 ggggaaatcg gtgtcccact gcacccggga gatcagcccg gcctggcgca gtctccgggc
    12721 ccaggcaccg atcgctgcgg gggtactcgt ggcgcggtcg gtcggcacga ccaggcgcag
    12781 ccgcaaatgg tcgtcggggt cgcggtaggg caggaaccac caccgcgctc tactgtccag
    12841 ttcggtgagc aggcccggaa gatggcgggt gagaatgctg ccgaagcggt cggggcggcc
    12901 gtagagcttg atgaggaaac gcccatcgca accggggagg tgaccatgct cgcgcccgac
    12961 gctctgcccg ccgtccagcc actgcggtgc tcgttgcggc tcgccgccca cggcgagagg
    13021 gatgacgagc tcgtgggcgc gcccgccgat ccatcccgca tcagcggccg tttccgcacg
    13081 gagtacggcg gcgccgtcgc gctgcacctg cgcgcgcagc agcgcccggt gcgcaggctc
    13141 ggtcaggtcc aggcggatgc gctggtcacc gtccccggca tagaccgtgc tcggagcagc
    13201 cacctggtcc cgccatgcgg ccagggaacg gtcccactgg gccccgtctg cctcgcgggc
    13261 ggccagttca gcggccgtga gcagccagcg cgccggggac aggatcgttc gtcggtaacg
    13321 cagcgcgggg aggaaaggca ggttcgtcgc ggctccccag tcaaaggtcg tgcacgggac
    13381 gctcatcgcg ttggtgacct cggtgaggaa ccggaccagc ggatgcgtgc ggtgaaccgg
    13441 ctccactgca ttgagggtca cgaactcaag cggccggtgc cgggtccgcg agatcaggta
    13501 gaggcgttgc gcgtccgcgg tgacgacgat gtcttccagg agcaccctcc cgttgtcgtc
    13561 gtggtcgtgg cactcgccaa cggcaaggac ggcgggcatc gcccggggag ctcgcgcgac
    13621 gttctcggtg tccacatgca gcgggggtgc ggagatctgt acggtcaggg caccctcggt
    13681 cgcggcggac gcggccgcat acgccttcgc catccgctcg cggtcaccgg ggccgaggag
    13741 gcccaggaac ctgccggtca ccgttccggc ggtgcgcgat actccggtga tcgcgagcgt
    13801 gaactccccg gctcccagcg cccgggtgct ggaggcgtgg acgcgcacgg tcagttctgt
    13861 ggtcggctgg acacgcatgt cggagcctgc tgtggtgagg tcggcgatca tggcgtcgtc
    13921 cagaacgatc tcgtgctggc gtcgcagcgc cgcgttctgc gcaagcgcca gcagtttcat
    13981 atcccgctcg gccaacgggc cgctctccgg ggcgggtggc ccgccgagga agccggccgg
    14041 atagcccagg ccggtatcgc cgtccacggc gtccaggatc ggtactagag cgcgcgggcc
    14101 gtagcgttcc aggaagcggc tgtgccagct cgcccaggcg cggctgagga aggggtggtg
    14161 ggccagccgt accagtgccg tcgccgcccg cgcggcctcg gtggcgaccg catacgggat
    14221 cgtcacctct ccctcgagcc gcagatcgac accgagcgcg ggcccggaac aggagctgag
    14281 gctctgcatc gcgttggtga gctgggcgcg ctgctctcgc gctcgggtgg cggtggtgtt
    14341 gtgccgggcc agagcgtcgg ctatctggcg tagctgtgca gtggtgttgg cgaccgtggc
    14401 aatgttctcg gcctccgctg cgtcgagtgc attcaggaga cgacccagcg catctgttgt
    14461 tgtgatcggg cagcgcaggt tcgtgagcag gaggcgctgg gcagttaggt ccgccagcag
    14521 cttgtcgatg acctccgcag gcacgtgggg gaagtcggcg ctgagcttgg acgcgaggtc
    14581 ctgcgcccgg atagggcggc gtgccgcgtc catggccgac atgacgggtg tggtggcgcg
    14641 gacccggacg tgggccgggg gaccgccgga gctgccgccc ccgcggtgtt cgagaatcag
    14701 gtggccgtcc ttctcgaccg ccagcgcgtg ggcctggacc gtcaggcgcg gcaggagcgc
    14761 ggggtcggtt tccagccgtt cgatcaccgc ggtcagccac gcagcgtctg gcttggcgac
    14821 ggcccggtgt ccggtgccga tgtgcaccgt cggcacgtca gcgatccggg caggcgccac
    14881 cccggcgaac aggccgaacg gtgtggcccg gcttgaagcg cgcagcaggt aacgcatgac
    14941 ggccaggacc gccttccgca cggcgggctc gggcatcttc cttccgtcgc agatctccca
    15001 gacgctgcgg gccagcacgg gacttgcctg ctctaaggcg gctgcgaagc cgggcatctg
    15061 caacagccgc tccagccaca accgccagga cgccacacct ccggtcggat cgggccatga
    15121 ccggacctgg tgccccggcg gccaggccac ggcccgcagc atcgctgcat cgacgtactc
    15181 gtacacccgc acccccatcg gagtgcggtg tccggccaaa gccagccgga caccgcggtt
    15241 caggactccg gacggcctgg ctacgggcag gtcgtcgagc aggcggactg gcaggtctgg
    15301 ccgcagccgt cgtcggtcat ccggatgagc ctgtcggccg aaggaccgga ctcgacgatg
    15361 gagacatcca ggtcccagcc ctcgaaatcc ccctcatggc tcgttaccgg cggggccgac
    15421 ggcgccgccg cgtcctcgaa ctggacggac acaaaaacct ccctgatgag ttgggtggtg
    15481 cgcacttccc cgcctccccg cgacgatgtc gcagggcgcg gagcctacga ccaggaaatc
    15541 tcgacggctc cgagctgttt cgccacaatt ccctgggacg gcttggccgt gccggagggc
    15601 atcggccggt accgaatgcg ggccgcgccg cgccgctgat gctcggatgc ccaacggcgt
    15661 agcaaatcga tgtagcgcgc cgcgactgcc tccgcatcag gcccgtgggc gaagacgccg
    15721 ctctcgaaac cgcctgtctc ctgattcggc cgtttggtgc ggtatgcgaa gctcccgccg
    15781 acgaccagcg cgggcacccc gcgcgtcacc gacagcgcga agacgccctg ctcgacgagg
    15841 tctttgctgc cgtgcagcat cgccatctca ggcgtgcttg tcgccaggaa gagctccagc
    15901 tcgtccggca ggtcgaaggc cgcaccggac cacacctcca gtccaggcga gcgcacggcg
    15961 gcggccaagc cattgatgtc gaagtcttgc ctctggtcat cgacgcgcag cccgatgccg
    16021 tcggcaaccc ggatgagtcg ctcggtgtag gcgccggctc cctgcattgc cacgaagccg
    16081 cacagccggt agctgtcgct gaccaggccc tcatcggcgc ggtcgaacgc gatcgagcgg
    16141 gtgagccccc gcatacgcag cgggacgacg atcctgccgt gctcggagag ctggtccagc
    16201 cacgccgacg ggatatccca cgccccggct gtgacgatga tgcggtcgaa cggcgcatgc
    16261 tcgggtacgc cagcgtcggc gtcggactgc accacctcga cctgttcgta tcccgccgcg
    16321 tccaggcaag tgcgggcgcg ctcgacaatc tccgcatcga tgtccactga gaccaccgcc
    16381 ccggtgtcgc cgacaagttc ggcgatgagc gcagcgttgt agccgcctga gccgacttcg
    16441 aggacccgca tgccaggttc gatctcggcc tgctccagca tcaccacttg gatatgggtg
    16501 gccgacagag aactgagggc agtaccgtcc tgatcgcgct tgatcaccag ggcttggtcg
    16561 gcggcgtacg cggctttcag cggctcgtcg acggcgaaca gatgccgagg cacggtggcc
    16621 acagcgccag cgagggtctc ggacgtgatc gcccccagat catgcagttc ccgcaccatg
    16681 gccgcccgca gcgaggccgc ttcgtcatcc acgccatttt ctcggaccgt agtcattgcg
    16741 tcaccctatc gagtcgtttc cgtgcagccc cagcactctc cgcagtggct ccatcgtcat
    16801 tcgtgagcac gaggcgtccg ggaagagcac agacggatct cggcggccgc cgctcgctga
    16861 ctgcgggcga gggtggtcgg ggcgcctgct cccagcgtcg gcgtgggctg ggcagtggcg
    16921 ccgtcctttc cggggcccgg ggccgtgccg tgtggacgca cacggtggcc gcaccgcgac
    16981 agagaagccc acttggataa ggtcgccggt gctcgccttc ggtccgcacc gggtgaaggc
    17041 ggcgaaggcg tcctcgaagg gctgggtcgt cgacggactt ccacccaata cgccagtcgt
    17101 tgcactcggc cagtacgtgc gtggcagccc ggtgttcgac atccgtgtac ctaccgcgga
    17161 tggcaggctc ggctcgacag cgaagtgcgg cggtcgagcg aggcagggcc ttgggtcggt
    17221 tggcatggtg ggcacccctt cctgtgtcag cgggtggcag ccgggcgtga agcccggttc
    17281 tcgtactcgg tgatgacgga gactttcgct gccgccggtg cggtgaagtc gcatcggaag
    17341 gtcacccatg cggccaccaa gcggcgcgca gcggtgatgc cgacgacgcc ttggccgagg
    17401 gtgaggacct gagcgttgtt gcactccacc gatgcctgca ctgatagcaa gtcgtgggcg
    17461 gtcaccgcgc ggatgccgtg gaccttgttc gcggcgatgg ccatgcccag tccggtgtgg
    17521 cagaccagca gcgcccggtc tgctagccct tctgcgacga gctgcgccgc agcgagcgct
    17581 acctcgggat aggcgggcgg cggatccccg ctgtcgttga catcgatgac gaaatcgacc
    17641 aaggggtgag cacacagatc accggtgagc gtactcgcgt actgccgacc ggccgggtcg
    17701 gctcctacgg caatacgaag aagagcgtgc agcccagaca tggaaggcac ggcgggtact
    17761 cctgtctgac ggttcgggtg tgaaggggac tgggagctac aagccgcgcg cggctggaac
    17821 ggcgagcccg gccaccgccc cgcttcccca cggggacgat ggccgtgact actgccgtga
    17881 accggatcaa gcgccgccaa cagaggcgtg tccgcctacg tcagccactc gagcacctgg
    17941 tctgcggtga ggagttggta ctgccacgtg cgcttgacgg tttgagccgc attcctggcc
    18001 cgcaagttct tcatcaagcc gcgggcgtcg cgccggatga tgctgactgg gcgcttcagc
    18061 accgacgcca tctgcgacac ccgcatcccc tgggcgagga gcggcacgag ggccagctgc
    18121 tcgcggggca ggctcagctc tgaaggatcc agaggcttgg gctgcgggag gcctccgagg
    18181 gcgtaggcgg cagcgagagc cgccgcgttc tcgctcttgg cacccaattt cagcttggcc
    18241 aggctgaggt agctctgaac ggtgttctgc cggatgccga gccgcagccc gacctcggcg
    18301 agggagcttc cgtcggccag gtactcgaag atctgctgtt ccctgggcga taggcgtgcg
    18361 gccgggttcg tgacggcctg ggtcactgct gtcctccgtg agttgcgtgc gtggtctagt
    18421 gagcgcgtac ggctggcccg cgccgcacgc cggatgtttg gaggggtgcg ctcctgggcc
    18481 atgcggatgc ggtagtgcac tccggtcgtc ctgggccccg acgggggcgt tgccggtgca
    18541 cgaaggggcg gcatgccgag cagtcagccc cgcccgggct gttgcctgcc gggtgagccg
    18601 agccgcccgg cggcggatta catgaccagc acaagtcacc tagggccgca acatcggcgc
    18661 cgccttgata gaccggctgg gatctcgcga acgaacggac gggggccgct cggtcactcg
    18721 acgggagcgt agtggtcggg gtggtcatgc ggacctccgg tcataggaca gcgcgacggg
    18781 cttaccaccc ggcctcggag cgcaggggcc cggctgagat cggatgagtc gtgttgatac
    18841 acaccgatgc aggtgctggc gagcggaagg cacgggacgg ggtgagcgag gagccacact
    18901 gggcgttcgc tacggcccaa gccgacggtg tacgggcgtc cgctgtgcag ctctcggacg
    18961 gccttgctgg cgccttggtg gtcgccgagc catgcccaaa cggtgccgaa ggcttcgcga
    19021 tccatgtcga cggcgatgtt cggtgcggtc gtcctgagcc aggtgatcgc gcggccgggg
    19081 aacccggtcg tcatgctcag cactacggcg tcggaccgat tcggttccgt gtagatcacc
    19141 tggcaccagt agccacgggg cagcgtcatg ctgacgaccg ctcctcgaca tacacggggc
    19201 cagtgatgtc ggtcaccttg gctgtcagca catcaaggac gtcttcggcg gccagtgcta
    19261 gccgacgcac atagcctcgg cctgccgcga ggtcggcagg tgggggcgag acttcgagtt
    19321 gctgggctcg gctcacgatc accgtgagtt ccggaatcgg gactccagcg gcacgctgga
    19381 ctgcgatgtt cagcaactgg cgcaggtggc gacggatgcg gggcgccagc tcgtgcacgt
    19441 cctcaacggt gagcagggcg gactgcaagc cgaaggccgt gtccaggtcg tcgtcgattc
    19501 cttcttcgtg gatgaacgag ttgtgcaggg cggccatgca cgtgtgaagg gccgtgactg
    19561 gagtgagccg ggcgggctct acgtccaagt gccagcgctg gcgttgaggc agctcaccga
    19621 tgcggtcgcc cggtaaagcg gagtgcggga gactctcggg gccggccgtt ggggggtggg
    19681 ggtggcgttc catcgtgtct gtactccgtg gggcccggga tttccggggt ctgttggccc
    19741 cgaggcggtc tgagggtgga tgaggctttc ggcggtgggc gaggggtgag gagtccgccg
    19801 ggtgctcggc cgcgcgggct cgtcatctgc ccctgctgtt ccgggagcgg gggcgagaac
    19861 ccgcgagcgc cccgagcgcc gagccagccc atcgcaccgg tgatcacctt gatcagggac
    19921 ggggcccaca gacatcactc ctgcggcttc gcaccgcgga aggccgagag ccgatgtccg
    19981 gccgccacgc atgcgcgagc gaggaagcga cggccagggc gatcggatgc gtgcgattgc
    20041 ccttaagcca caccctattg cgcggtctag caagtggtgc ctggaggccg tggtcatcag
    20101 ctcacctcca gggtcaggtc gcaccagatc gcgtcgttgt cgctgttccc ccaggagccg
    20161 tgtcgctggt tggcgatgga ctcgacgacc cacaatccgc ggccgttctc cgcgtgagcg
    20221 tccggcttgg agacgatggg tagacggctg ttcatcccgt cgtgcacccg aatgtgcaag
    20281 tggccgtccc ggagggagag agtaagggtg atctcgcgac cgtggctgtg ctgcaccgcg
    20341 ttggtgacca gctcggatac gacaagcgcg gcgtcatccg ccaaggagga caggccgctt
    20401 tggttcaggc gagtcctggt caggcttcgc atctctcgga cctgcaacgc gtcaatctgt
    20461 gtaaggggtt ggcctggcct gcgctcagcg atctgaaagg tgcgactcaa caggtcagcg
    20521 tcggtcatgg gagagcgaag cggtcgttcg gcagtcgttg tcatcacgtc ctcttggggg
    20581 cacggaggac cgatcgggcg gcggatgtcg ccctacgagg agtggtccgc tcgttgtcag
    20641 ggcggagacg ggacgggcat gggccaaaca gaggcgtcgt ggtgccgcgc atgtccttcc
    20701 cttctccgca gcgacaacgt gatcaccgca tctgaccgag tggtcagcgc agtggacatg
    20761 agtgtggggc caggaggcac ccgtgctgat ctctgcggcg atatctctgt agagataagg
    20821 aatcccgcat atcgtgtgga ccgtcgggaa gttcgaccca gggggccgcg ctatgagacc
    20881 gccgagccgc gtatgcgaga ggtgtgccac cgagctgagt cagtacaacc ccgatgccct
    20941 gtgcgcccta tgcgcaaagg cgggaacggc gccgggagtt cccgatcgag cttggcgcga
    21001 cgaagctgtt taccgggccc tggccgcttg ggatttcggc gatgtgctgc gcctggtgcg
    21061 caagcggtct ggcttatctc agatggccgt gcgtgagctg acggcgctac ctcagtcctt
    21121 catttccggt ctagaacgcg gtcagaagca gatcgggagc cctgccaccc ttctcgacct
    21181 tctcaacggc ctcggcctgc cctccgacct gcagcctttg ctgctgacac ccctacgcgg
    21241 tgatgcgccg aagcctggtc acagccgatc cgcagaggcc gtactgccct ggacggcgga
    21301 ccgtatggtg acgtcacttg aagtggctat cggaggtacc gctatgaagc gccgccgcgt
    21361 gctaaccgcc ctgagcggag ccgcactcac ccagtacgtc atgcagtccg ccatcgcccc
    21421 cgcggaagcc atggccgctt cttccgggac cacgactgtc accgacgccc tgatcgactc
    21481 gcttcaaggc accaccgacg cactccgtca ggtcgacgcc accagcggga gcggaagcct
    21541 cgcctacacg gcgaagactc acctgcggat gctcctgaac ctgctcaagc aaggctccta
    21601 tacggagaat cacgggcgcc gcctggctgc cgtcaccgcc gacacggcag cccagactgg
    21661 ctggtacacc ttcgacagcg gcgaccacga caccgcccag cacttcttcc tcggcgctct
    21721 gcgcgcagcc cacgcttcag gcgactcccg cctgcacgcc ggcgccctcg gcttcctcgc
    21781 tatccacggt tactccgtcg gcgacccgcg cgacgctgtc accgccgctc gcacagcgcg
    21841 ccaggcaatc accgatcacg acgcccctgc cctgaacgcc atgctcctca cccgccaggc
    21901 tcgcggccac gcccgactcc gtgaagagcg ctacgccctg gccgcacttg ccgaagccga
    21961 agaactctgc gcccgcggcc ggggtgcgga cgatcctcac tggctgtact ggatcaactc
    22021 gggggagatc ctcggacaga ccggtagctg ctacctcgac ctgggccagc cagctcgtgc
    22081 agcccaatcc ttcgccgcgg cccgcgacgt gcttagtcgg gatgagaccc gaaccaccgc
    22141 ccagttcctc tcccgagccg ccaccgcaca gatgcgcgcc gccgacgccg acgctggctg
    22201 cgccactgct catgacgtcc tgaccctcgc cgaaggcatt caatccgccc gccttgacga
    22261 ccacctgcgc agcatgctca acgaggcgcg ttcctacggc gcctcctcac tcgcccggga
    22321 tctgttggaa cgcggggcaa gcatcatgcg tcagcgagcc gccgcatgat cctggttctc
    22381 tgggacattg accgcaccct cctctacacc ggcgacaccg accggctggt ctatcgggaa
    22441 cttttcgagg aggtagtggg ccggcctgcc gagagtttgc ccgctcgggg aaccggggtg
    22501 acgatgcccc tcgctgtccg ggagctgctg cgcgtgaatg cagtggaacc cgagctgatc
    22561 gaggaactcg cgcagcgcat cgtgcagcgt atgcccgcgc aactagaacg tcaccgtgac
    22621 gaactttctc gcacggggca agtcatgccc agtgcacccg ctgcccttgc cgccgtgcaa
    22681 ctggagcccg ggctggttcc cactgtggtc actggcaacc tgcgaggcag cgccgagatc
    22741 aagctcaagg ctctgggcct ggacgagtat ctcgacctca gcatcggcgg atacgcctcc
    22801 gacgacgccc accgccctgc cctcgtgcgc gtggcacagc agcgagccgg cacacgccac
    22861 gcgtatacct tcacacggga tacgaccgtg atcatcggcg actctctcga agacgtccgc
    22921 actggacggg agggaggcgc caccgtggtc ggcgtcgctt ccggtaccgc ctcagccgag
    22981 aaactcgctg ccgccggcgc ctgtcacgtc gtccctgacc taaccgacgt gcaacgcgta
    23041 attcgcctga tcaaccaatg tgctgcctcg gacgttgacc aaggctgtcc tgagccaccg
    23101 caggatgcga tgtaagagga gttcagatga tcgaggtgcg gcccagcgag cagatgcgca
    23161 acctcggcat cgttcagcac gccgccggtc tggtatgcgc tgggggaggc gaagatgtcg
    23221 ccgagcacag ctgcggtgag catgtcttct ccgacgaatc cggcgtgcaa tgacttatga
    23281 cctgagtcgc ctccggagat cacagctact tgccccgcgg gcagtggcgc gcgatggaga
    23341 cacagccgct gggtgagatc gacgcgcacg atgtcggagt gggcttcaga aatcccggag
    23401 agcatatctt ccacgacatt gtccgaagaa ttgagaattc tcttcattgt tgagacagtt
    23461 cacggctgat gcaacggcaa gtagctggtg gcggcatgag ctgcatagct tggctacaca
    23521 agacgacacc ttggcctccg tcgcgggtgg attggggcac ccatacgaca cccggcaacc
    23581 gtgaagagcg gaaccccggt ttcctcctac gtcacatgga ctggcgtgga gggcaagcgg
    23641 actttgcgat aggtgacaat tgggggcgta ggctgagcag ttgaatcaga gtgagctgca
    23701 ggagtttggg gattcccctg cgcgcctggt tgtgaaaggg agctgggcat tgagtggggt
    23761 ggtgcgattt cacccgtagg tgtgattccg ctctgggtga gctttgcggt gttgtggtcg
    23821 catcccaacc gcgaacggtg gaggtcttcc atggtgcccg tcagtttcac ggctgtactt
    23881 cttctaccga tttccctcac gaatgcaccg atcgtattga gtgtggcccg cgcatgggga
    23941 cagactgggc gcggtcgtca ccgacgtgtc actcgccacc acgcgggacg aggggtgcgg
    24001 cgatgattgg cgctgcggga gaagggcaag cctcggtgtg gcggtggaac agccgtagcg
    24061 gcgatgccgc ggtgtctgcc cgagtagccc tgcggagcgc tttggcccag ctggggctac
    24121 ctgacggagc ggtatgtgat gtgacacggg cggcctggga gttgactgcc aatgccatgg
    24181 agcacgcgtg tgggccatac gagatgcggc tgcaacgaaa aggcgcatcg ctcgtgttcg
    24241 aaattgaaga cggggaccca cgcatcccgg ccactcctcc tgctgtccct tccggagggg
    24301 agtttgaagt agatggagat gatctcgaca gtctgattgc tagtctatcc gaggatgggc
    24361 ggggactgcg tatcgtggat caaattacag gtggccaatg ggggttccgt ccctcaaggt
    24421 caggtataaa ggccgcctgg atggtgatct ctgacccccc gaaaggatga tccttccacc
    24481 tcggatgctt ctggcggccg cgcgccgcat cagcaagtag ccgctgctgc gtgattacca
    24541 ttcattcggc gccaagtacc gctcctgtcc gggcagagat gaacgaacct gtagcagatc
    24601 gagtgactgt cggagtggtt tagttgacgt ctcgttggga actccaagca cgtgatcgcc
    24661 tatagattct gctttggctt tggagggtgg tgaaatcggg gaatgaatgc caataagctt
    24721 acaagattag ccttggtgct cgtcccggtt gcgggagcga ctctatgcgg ctgctcagag
    24781 attccatcgg acgctaagcc gttggtgagg ggggcggagt cgagttcatc gcatgagagg
    24841 tctactcagg ggcacaggag ggcactgagc gcgtacaggg ctatgtggca ggatctgact
    24901 gtggcctcgg ccaactccga tgcgtcctct cctctgttgg acgaccacgc gagagatggt
    24961 gccttggagc tgatgaagta cggcttgaag gaggcgcaga gagaaaaggt cgtcactaaa
    25021 ggggagctgt atgtcaatcc gcaggtggtc acggcaaccc ctaaagaggt gaaactgcgg
    25081 gactgcgtgg acggcacagg ctggctgcag tacaagctga acggaacgct gaagaacgat
    25141 gttccgggga gccatttcaa ggcggacgcc cgtgtgctgc gtaacgggac tgtatgga
//
