LOCUS       NZ_JABWGO010000018     18026 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Nonomuraea rhodomycinica strain TBRC6557
            NODE_18_length_101864_cov_24.8405, whole genome shotgun sequence.
ACCESSION   NZ_JABWGO010000018
VERSION     NZ_JABWGO010000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nonomuraea rhodomycinica
  ORGANISM  Nonomuraea rhodomycinica
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 101864)
  AUTHORS   Chanama,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUN-2020) Microbiology, Mahidol University, Faculty of
            Public Health, 420/1 Ratchawithi Road, Ratchathewi, Bangkok 10400,
            Thailand
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2020
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013363995.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 04:09:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,940
            CDSs (total)                      :: 8,866
            Genes (coding)                    :: 8,758
            CDSs (with protein)               :: 8,758
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 108
            CDSs (without protein)            :: 108
            Pseudo Genes (ambiguous residues) :: 0 of 108
            Pseudo Genes (frameshifted)       :: 12 of 108
            Pseudo Genes (incomplete)         :: 99 of 108
            Pseudo Genes (internal stop)      :: 6 of 108
            Pseudo Genes (multiple problems)  :: 8 of 108
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:20:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 18026
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABWGO010000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..18026
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="hserlactone"
                     /region_number="1"
                     /rules="Autoind_synth"
                     /tool="antismash"
     gene            <1..361
                     /locus_tag="HT134_RS41820"
                     /old_locus_tag="HT134_41795"
                     /pseudo=""
     cand_cluster    1..18026
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="Autoind_synth"
                     /kind="single"
                     /product="hserlactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..18026
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[7381:8026](-)"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(7382..8026)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="Autoind_synth"
                     /neighbourhood="10000"
                     /product="hserlactone"
                     /protocluster_number="1"
     CDS             <3..361
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543109.1"
                     /locus_tag="HT134_RS41820"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41795"
                     /product="short-chain dehydrogenase/reductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="EVAEFGVKVTIIEPGGFATRGGKNPNPLDNGHVATPDPAYDGLRR
                     RLGAMAGKQPAGDPAAAAQALLTLVDTDNPPLRILFGQGFRPMIEQAYADRLKTWADWQ
                     DLSAQAQGHLDQADR"
     gene            428..1324
                     /locus_tag="HT134_RS41825"
                     /old_locus_tag="HT134_41800"
     CDS             428..1324
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631708.1"
                     /locus_tag="HT134_RS41825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41800"
                     /product="RNA polymerase sigma-70 factor"
                     /protein_id="WP_175606058.1"
                     /transl_table=11
                     /translation="MSDHATDAATEAFLAHRNLLFTVAYEMLGSAADAEDVLQETWLRW
                     VKADQDQVQDQRAYLIRITTRQSLNRLRSMKLRKEAYVGSWLPEPLLTAPDAAEDVVLA
                     ESVSMALMLVLETLAPTERAVFVLREVFDVGYDEIAAAVGKSPDAVRQIAHRARRHVEA
                     RRPRQAVPARRSRAVLESFQRAVETGDPQRLLDVLAPEVVLVSDGGGVKQAALRPISTS
                     DKVARYIAGGIGKAKVAITSELIVVNGGPALVLRVDGEVDGVMAIRVEDARITGLYYVR
                     NPEKLTRIASETPLTLR"
     misc_feature    1371..1386
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.86"
                     /tool="antismash"
     gene            1389..2603
                     /locus_tag="HT134_RS41830"
                     /old_locus_tag="HT134_41805"
     CDS             1389..2603
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893499.1"
                     /locus_tag="HT134_RS41830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41805"
                     /product="cytochrome P450"
                     /protein_id="WP_175606059.1"
                     /sec_met_domain="p450 (E-value: 1.1e-20, bitscore: 66.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKSVAGVELPVERGCPFAPPAEYERLRERAPISRVRLMGGAEGW
                     LVSGHEEARAVLADRRFSSDRRKDGFPLVVGDAETQRQLRAQPPLMVGMDGAEHAAARR
                     PVIGEFTVKRLAALRPRIQDLVDRFVDDLLATEERPVDLVRALSLPVPSLVICELLGVP
                     YADHDFFQSRTAVAVRRTSSPQERLGAFADLRAYMDELVTRKESEPGDDLISRQIARQR
                     QDGAVDHAGLVSLAFLLLTAGHETTANMISLGVIGLLSHPDQLALITADPARTPLAVEE
                     LLRYFSITDVVTSRVATDDVRIGEADIKAGEGVVVSGLSANRDPAAFENPGDLDVERGA
                     RHHLAFGFGPHQCLGQNLARLELQIVFDTLFRRIPTLRLAAPVEDLPFKSDAIVYGVHE
                     LPVTW"
     gene            2702..3358
                     /locus_tag="HT134_RS41835"
                     /old_locus_tag="HT134_41810"
     CDS             2702..3358
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654536.1"
                     /locus_tag="HT134_RS41835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41810"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_175606060.1"
                     /transl_table=11
                     /translation="MDLFSRSWTALRTAVAELADEDFTRPSGCAGWLVRDLVCHLVIDA
                     QDVLITLVTPAATAPTRDAVTYWEVSRTPPTGDDPLDALTVRLAAAYEEPRLLKFHLDD
                     VGSAAGRAAELADPDLWVGTRGQVITVRDYLSAYVMEWTLHHLDLVAHLPGVAGPPAEG
                     LARSRETLEEIAGTAFPASFSDTDALLVGTGRRAATGAERAELGELAARVPFVLG"
     gene            complement(3401..3934)
                     /locus_tag="HT134_RS41840"
                     /old_locus_tag="HT134_41815"
     CDS             complement(3401..3934)
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017576115.1"
                     /locus_tag="HT134_RS41840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41815"
                     /product="YceI family protein"
                     /protein_id="WP_175606061.1"
                     /transl_table=11
                     /translation="MPTMTPLSELTGDYVLDPTRTRIGFVAKHTMASRVRGRFEEFEGG
                     AHLDGDDPSRSGVRLTIRAASLQTGNRRRDEQVRAAFLHVAQHPALTFTSTEVRHLGGR
                     SFTVTGALTIRGVTKPVTVDVELTGTPGDAEVRFTGAVTIDRNDWGVNWNAATTVMVRP
                     KVTLELDVAAVRRT"
     misc_feature    3948..3961
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.81"
                     /tool="antismash"
     gene            4083..5018
                     /gene="sigJ"
                     /locus_tag="HT134_RS41845"
                     /old_locus_tag="HT134_41820"
     CDS             4083..5018
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="sigJ"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891428.1"
                     /locus_tag="HT134_RS41845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41820"
                     /product="RNA polymerase sigma factor SigJ"
                     /protein_id="WP_175606062.1"
                     /transl_table=11
                     /translation="MSIPSEPGDGRLDPGLSAIVSERRQLINLAYRLLGSLADAEDVVQ
                     ETYARWYAMSGAQRQAIASPGAWLTTVAGRICLDVLGSARARRESYVGEWLPEPLPDRT
                     EWIEERPGDTTADPADRVTLDESVNMAFLVVLESMTPAERVAFVLHDVFRYSFAEVAEV
                     VGRSPAACRQLASSARRRIRDARTPATPAARRAGVVRDFKQAWEAKDIDALIGLLDPEA
                     TAVGDSGGLVSAVLDPVEGGERIARYLIEVIGMAPDLAILERTVNGQPGLVAQREGLIE
                     AVFAFDVAGDRITRIWAVRNPEKLRPWTAG"
     misc_feature    complement(5057..5072)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            5288..6214
                     /locus_tag="HT134_RS41850"
                     /old_locus_tag="HT134_41825"
     CDS             5288..6214
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543108.1"
                     /locus_tag="HT134_RS41850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41825"
                     /product="RNA polymerase sigma-70 factor"
                     /protein_id="WP_175606063.1"
                     /transl_table=11
                     /translation="MNERSEPTADTSEPLAGDRRTDAATEAFVTHRNLLFTVAYELLGS
                     AADAEDVLQETWLKWAGVELGTVQDQRAYLVRITTRQALGRLRTLGRRKESYVGPWLPE
                     PLLTAPDVAEDVELADSVSMAMLLVMETLQPTERAVFVLREVFDLSYDEIAEAVGKSPA
                     AVRQIAHRARSHVAARRPRGLVSPDETRDALEAFRRAVETGDLQRLLDILAPDVVLLTD
                     GGGVVRAALAPVVGAGTVADLMGRINAVASLHPAQVNGHPALIVRVGGEVDTVMAVRVE
                     EGLITGLYAVRNPAKLSRVEQEIALSR"
     gene            complement(6244..6684)
                     /locus_tag="HT134_RS41855"
                     /old_locus_tag="HT134_41830"
     CDS             complement(6244..6684)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017537817.1"
                     /locus_tag="HT134_RS41855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41830"
                     /product="DoxX family membrane protein"
                     /protein_id="WP_175606064.1"
                     /transl_table=11
                     /translation="MAPFIALIGGFVVLRVLGLAGIEVLDSWQPALRGALALMFVTTGI
                     PHFVPSWRRDFVAMIPPVFPRPALLVTLTGVLELAGAAGLLIAPLAPFAAIGLALLMAA
                     MFPANVSAARRGLTLAGKPVTPLPIRTALQVLFIAAAVAAAV"
     misc_feature    complement(6730..6748)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.12"
                     /tool="antismash"
     misc_feature    6747..6767
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.33"
                     /tool="antismash"
     misc_feature    6804..6817
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.1"
                     /tool="antismash"
     gene            6804..7379
                     /locus_tag="HT134_RS41860"
                     /old_locus_tag="HT134_41835"
     CDS             6804..7379
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634391.1"
                     /locus_tag="HT134_RS41860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41835"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_175606065.1"
                     /transl_table=11
                     /translation="MRPIKQNGYHHGNLRRAVIDAALEAIAESGPAGWSLRELARRAGV
                     SHAAPAHHFGDKTGLLTAVAAEGFGMFADALERAAGDALEVGVAYVRFAVGHRPYFEVM
                     FRPELYRMDDPDLATARERAARVLVTSSGTLSPAPAQDRLTTIAAWSLVHGFAGLWLSG
                     SLPEAAHEDPEALARSVIRLFSGMSSPG"
     gene            complement(7382..8026)
                     /locus_tag="HT134_RS41865"
                     /old_locus_tag="HT134_41840"
     CDS             complement(7382..8026)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hserlactone: Autoind_synth"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012967.5"
                     /locus_tag="HT134_RS41865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41840"
                     /product="acyl-homoserine-lactone synthase"
                     /protein_id="WP_175606066.1"
                     /sec_met_domain="Autoind_synth (E-value: 1.4e-28, bitscore:
                     92.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGSPEDGCARRIVVGRAGELPPWLLDGMFRLRHAVFHERLRWDV
                     DSRDGRERDRFDDCDPVYVISYAEAGRKVTGCCRLLRTDGPYMLRDVFPEALRGVPAPR
                     DPAVWEASRLATDRPWSGAVATGLGSLARALVREVFGWVDRHGDTVVAFSSVDLEHGLN
                     AMGVPTRRFGDGGATRLDGLVCSAYAMSTAAFLRGAHPARKDPPHCPLARE"
     misc_feature    complement(7736..7738)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8120..8548)
                     /locus_tag="HT134_RS41870"
                     /old_locus_tag="HT134_41845"
     CDS             complement(8120..8548)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HT134_RS41870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HT134_41845"
                     /product="hypothetical protein"
                     /protein_id="WP_217709011.1"
                     /transl_table=11
                     /translation="MTRRHGDAAASGGVVFRAAGTVALPRSRSAASDGEPGSAVWGTLI
                     VGGVLQTVFAAALLGLGADPSWMWLMVVAGLATMTQQVGITMGTPIMSAVVTAAMAGTG
                     ASAILGGLKVAIGVNAAIVLLGVLTSALFLRGARTSAR"
     gene            complement(8587..11136)
                     /locus_tag="HT134_RS41875"
                     /old_locus_tag="HT134_41850"
     CDS             complement(8587..11136)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040138.4"
                     /locus_tag="HT134_RS41875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41850"
                     /product="fibronectin type III domain-containing protein"
                     /protein_id="WP_175606067.1"
                     /transl_table=11
                     /translation="MERAMTAGGRAARPGAAALLTLLLSLLVSLCLVRAAAPGVADSAP
                     TGPGLAAAGLQPGPGQYFPAKARVMDGVTIAARTTVTVKIAGAPNVPTAGVASAAINFA
                     VKGTDGAGGLVVFPSGASQPGVTGATYQANVYNHELMLVKVGADGQVKVANTGQVAAKV
                     YADVHGYTLAAAGGSAGSTYVPLNTARVASKVSIPANGTATLSPLGLGGIPASGVSAVA
                     FALVAKGTAAGKIRAYPSGSAAPVDTVLDYRANQFLSNMVFGTLGADGKIALTNVGTAA
                     VDVYADVSGYFGKPASAAAGSAAVPVAPARIASAITIPANGTATLAPLGEGGVPDTGVT
                     AVGINFTAKSTGSGSLRVHPSDQSSPPGGGSVDYLPTDPYAQYVPVKVGADGGITIRNA
                     GSSAVTVWADVYGYFAAPQAPGAPLDVRATAGDGQVAVTWKAPADGGAAITAYRVTPEP
                     SGDPVEVGGEATTATVTGLENGRTYRLFVVAVNAVGAGPDPGVSDEVAPQGPDSPVARF
                     TVACDKPAKACTFDASTSTGGGGGNVTGYSWSFGDGASASGATASHTYGTSGRYIVGLV
                     VTNEKNLSSSTQQEADFGVPPTASFSTACVNSTLTCTFDASFATDPDSAIATYEWDFGD
                     GAAGAGVRVSHRFAAGTHPVTLKVVDDGGLSSTATKSLTVDTTDAAPTGRIVASCEDAT
                     RWCGLEAQSSDPDGEIVRYEWDLGDGTTITDTEARNAVHTYAGAGSYTVKVTLVDDQGA
                     ATTVTTQVDIRAAGDGAEYRAIISYTCVELQCEFDASDSIDSDGAVVAYSWDFGDGGTS
                     TDRIAAHTYAAPGTYTVRLVITDDKNRTVGTTRQATA"
     gene            complement(11121..12287)
                     /locus_tag="HT134_RS41880"
                     /old_locus_tag="HT134_41855"
     CDS             complement(11121..12287)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HT134_RS41880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HT134_41855"
                     /product="hypothetical protein"
                     /protein_id="WP_175606068.1"
                     /transl_table=11
                     /translation="MLAFVLLATATQIPAAGASADSGVFLTGKALDATGAPAGGADVYV
                     FDVTEESEHNDSVAHAKANPDGRFELSMPLNAGKTAASGNDGWSNYMALVSRAGKFDVQ
                     FFSRRRETGGQWIAPSHTSAARDVVTLKADQRPFTPPAGSRAAELLASARASQAAGAAG
                     PAEKVSMKSVVLARYSNVPTTVARIEVARNTKVKFTYGRRADTEVEVGVEFEEGRWKMG
                     GSKHIGNDVGYEVPYTLDPGLNKPAARYMEAGMDYEDRLEWIGTTFPVAYTKRVATRWT
                     GTLYGYSTWVNGCESQSCMSHVACYFKHNSGLKKTRGENRKYTAAANVAGLMLGATSGW
                     SSNVSMEYDFAVHGNPELIGYCMGGNNTWPPYAQEVYMFTTTTPWNGQ"
     misc_feature    12499..12512
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.72"
                     /tool="antismash"
     gene            12546..13223
                     /gene="wrbA"
                     /locus_tag="HT134_RS41885"
                     /old_locus_tag="HT134_41860"
     CDS             12546..13223
                     /EC_number="1.6.5.2"
                     /GO_function="GO:0003955 - NAD(P)H dehydrogenase (quinone)
                     activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /gene="wrbA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891231.1"
                     /locus_tag="HT134_RS41885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41860"
                     /product="NAD(P)H:quinone oxidoreductase"
                     /protein_id="WP_175606069.1"
                     /transl_table=11
                     /translation="MTVKVAIIYYSSTGTVHSLARAVAEGAASAGAEVRLRRVAELAPD
                     SAIDQNPSWRRHADAARSITEASVEDLAWADAFAFGTPTRFGGPAAQLKQFIDQAGGLW
                     RDGQLADKPVTAFTSAYNRHGGSEATILSLANVFYHWGALIVPTGFTDPAVYAAGGNPY
                     GTSMTGPAMDGADTATLEAARYQGRRLARIAIRLLEGDRTAEDTPPDGNAREALAATTS
                     PSA"
     gene            13252..14679
                     /locus_tag="HT134_RS41890"
                     /old_locus_tag="HT134_41865"
     CDS             13252..14679
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891230.1"
                     /locus_tag="HT134_RS41890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_41865"
                     /product="MFS transporter"
                     /protein_id="WP_175606070.1"
                     /transl_table=11
                     /translation="MTSVNTAPQPVRPHALPAWMITALACACQFMVILDSSIVNLALPA
                     VREELGFTPTGLAWVVNGYLLTFAGFMLLGGRAADLFGPRRMLVAGLSLFSVSSLVAGL
                     ATAPQVLVAARVAQGVGAAMMAPATLAVINTSFTEPNARAKVFGAWSAAGGVGGMAGAI
                     AGGAITTGLSWRWVFLINVPIGAVLIVVALMAPAGTRTARRESLDLTGAVTGTAGLAAL
                     VYGVMQSADHGWTSVPVAGPVVAGLLLLVVFGVVQARLAARPMMPLRLFRARGVAVGNG
                     MLLLFGAIPIAMWYFTSLFLQNVLGHSALQAGLGQTPAAVTFLVIARWAAPLLPRTGVR
                     PLVLAGSACFLAGFGWLAQAHPDSGYVTGVLGPTLLIATGIGLTFPTLMAAATADVAEG
                     DAGIVGGLATTASQVGGSVGLAVLATVAGARAASEAGASSSPAALATGYDLVFLIAAGL
                     GLAIAAASMLLPRHRRD"
     misc_feature    complement(14927..14942)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.71"
                     /tool="antismash"
     misc_feature    complement(15022..15036)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 20.83"
                     /tool="antismash"
     gene            15372..15680
                     /locus_tag="HT134_RS41895"
                     /old_locus_tag="HT134_41870"
     CDS             15372..15680
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HT134_RS41895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HT134_41870"
                     /product="hypothetical protein"
                     /protein_id="WP_175606071.1"
                     /transl_table=11
                     /translation="MAPTILMAADSEFPPELVDKQVALYAAIDKVAEIVAAEPKPPEGE
                     ALTAEQRQALDDALAEHRVALEQARATQSKALDEESKPNSPSTPRQRLPVYRLSPRT"
     misc_feature    15648..15650
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     tRNA            complement(15849..15920)
                     /anticodon=(pos:complement(15886..15888),aa:Pro,seq:cgg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HT134_RS41900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HT134_41875"
                     /product="tRNA-Pro"
     gene            complement(15849..15920)
                     /locus_tag="HT134_RS41900"
                     /old_locus_tag="HT134_41875"
     tRNA            complement(15933..16006)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HT134_RS41905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HT134_41880"
                     /product="tRNA-OTHER"
     gene            complement(15933..16006)
                     /locus_tag="HT134_RS41905"
                     /old_locus_tag="HT134_41880"
     gene            complement(16075..17490)
                     /locus_tag="HT134_RS41910"
                     /old_locus_tag="HT134_41885"
     CDS             complement(16075..17490)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HT134_RS41910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HT134_41885"
                     /product="hypothetical protein"
                     /protein_id="WP_175606072.1"
                     /transl_table=11
                     /translation="MKFRKDPDRSHHEILVELHDSLDRRYRPEDVADLVLQALEGRLSR
                     RERVVLGRAAKHSSRKTAWFSSMSADYVRPVGGARQVAAATRLFERSVEVDPDDPESLL
                     EFAATMGDAIRWAPDRSDFLADRLNRQSRTEAGMELSKRQYNRRFRMLRRLAAKAGTLG
                     LEQDKRRLLMVGVTGFGAGIPRERFLADPDAACFVAYYTARRKLRREFSLSGRENPFDE
                     IASILLDRCTDGSDWWMIAQVRTTPDVLEHLTEEERGRLLGQWSAVMRHSAGMLRDRWD
                     PATDRTSMIVRRGDDSSTWNNLAAAYNAARAGWLACLASLDALDLLDVACPGKAMRLMA
                     ADLAAWHQSSGSDVDPNTAVWAALPPPWEVLDGIQVSTRADVEAACRTAGLDPEKCGWT
                     APAARRGAAVFRPTPELVHGVSVADPVWASLLRRAGAFSGKPLKPELAADACHGLVSGV
                     VVSDLPAADRPPQ"
     misc_feature    17689..17701
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     misc_feature    18007..18018
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
ORIGIN
        1 cgaggtcgcc gagttcggcg tcaaggtcac catcatcgag cccggcggct tcgccacccg
       61 gggcggcaag aaccccaacc cgctcgacaa cggccacgtg gccacacccg accccgccta
      121 cgacgggctg cgccgccgcc tgggcgccat ggccggcaag cagcccgccg gcgaccccgc
      181 cgccgccgcc caggccctgc tcaccctcgt cgacaccgac aacccgcccc tgcgcatcct
      241 gttcggccag ggcttccgcc cgatgatcga acaggcctac gccgaccggc tgaagacgtg
      301 ggccgactgg caggatctgt cagcgcaggc ccagggccac ctcgaccagg cagatcggtg
      361 acccgcggcc gacgttgacg ccagggcggg ccggagcgga cggcccgccc gcaacaagga
      421 acgagacatg agcgaccacg ccaccgacgc agcgaccgag gccttcctcg cccaccgcaa
      481 cctgctgttc accgtcgcct acgagatgct cggatcggcg gccgacgccg aggacgtcct
      541 ccaggagacc tggctgcgat gggtcaaggc cgaccaggac caggtgcagg accagcgcgc
      601 ctacctgatc cggatcacca cccggcagtc gctcaaccgg ctgcgcagca tgaagctgcg
      661 caaggaggcg tacgtcggtt cctggctgcc cgagccgctg ctgaccgcgc cggacgcggc
      721 cgaggacgtc gtgctggccg agagcgtgtc gatggcgctc atgctcgtcc tggagacgct
      781 ggcgccgacc gagcgcgccg tcttcgtgct gcgcgaggtc ttcgacgtcg gctacgacga
      841 gatcgcggcc gccgtcggca agagcccgga cgccgtccgc cagatcgcgc accgcgcccg
      901 ccggcacgtc gaagcccgcc gcccccggca ggccgtcccg gcgcgccgga gccgggcggt
      961 gctggagtcg ttccagcgcg cggtcgagac cggcgacccg cagcgcctgc tcgacgtgct
     1021 ggcccccgag gtcgtcctgg tcagcgacgg cggcggcgtc aagcaggccg cgctgcggcc
     1081 gatcagcacc tccgacaagg tggcccgcta catcgccggc ggcatcggca aggccaaggt
     1141 cgcgatcacc agtgagctga tcgtggtcaa cggcggcccg gccctcgtcc tccgcgtgga
     1201 cggcgaggtg gacggcgtca tggcgatccg cgtcgaggac gcccgcatca ccggcctgta
     1261 ctacgtccgc aaccccgaga agctgacccg catcgcctcg gagaccccgc tcaccctgcg
     1321 gtgagcaccg gcggcggtga cgccgccgcc ggacaacccc caccagagcg ttgaccggga
     1381 ggtcattgat gagcaagagc gtcgccggtg tggaactgcc ggtcgagcgt ggttgcccgt
     1441 tcgccccgcc cgccgagtac gagcggctgc gcgagcgggc gccgatcagc agggtccgcc
     1501 tgatgggcgg cgccgagggc tggctcgtgt ccgggcacga ggaggcccgc gccgtcctcg
     1561 ccgaccgccg cttctcctcc gaccggcgca aggacggctt cccgctcgtc gtcggcgacg
     1621 cggagaccca gcggcagctg cgcgcccagc cgccgctcat ggtcggcatg gacggcgccg
     1681 agcacgccgc ggcccggcgg ccggtgatcg gcgagttcac cgtgaagcgg ctggccgcct
     1741 tgcgcccgcg gatccaggac ctcgtcgacc ggttcgtcga cgacctgctg gccaccgagg
     1801 agcgcccggt ggacctggtg cgggcactgt ccctgccggt gccctcgctg gtgatctgcg
     1861 aactgctcgg cgtgccgtac gccgaccacg acttcttcca gagccgcacc gccgtggcgg
     1921 tgcgccggac gtcgtcgccg caggagcgcc tgggcgcctt cgccgacctg cgcgcctaca
     1981 tggacgagct ggtcacccgc aaggagtccg aacccggcga cgacctgatc agccggcaga
     2041 tcgcccggca gcggcaggac ggcgccgtcg accacgccgg cctggtgagc ctggccttcc
     2101 tgctgctgac cgccgggcac gagaccaccg cgaacatgat ctcactgggg gtgatcgggc
     2161 tgctcagtca ccccgaccag ctggccctga tcaccgccga ccccgccagg acgcccctgg
     2221 ccgtggagga gctgctgcgc tacttctcca tcaccgacgt ggtcacctcg cgggtggcca
     2281 ccgacgacgt gcggatcggc gaggccgaca tcaaagccgg tgagggcgtc gtcgtctcgg
     2341 gcctgtcggc caaccgggac ccggcggcgt tcgagaatcc gggcgacctg gacgtcgagc
     2401 gcggggcccg ccaccacctc gcgttcggat tcggcccgca ccagtgcctc ggccagaacc
     2461 tggcccggct cgaactgcag atcgtcttcg acacgctgtt ccgccgcatc cccacgctgc
     2521 gactggccgc gccggtcgag gacctgccgt tcaagagcga cgccatcgtc tacggcgtcc
     2581 acgagctgcc ggtcacctgg tgaagggccg cctggcgcgg ccggtcacct gctgaaggcg
     2641 ttcgagcgcg gctcggccgg ggtgcttgtc cgccccggcc gagccggact accgtgccga
     2701 ggtggatctc ttctcacgct cgtggacggc gttgcgcacg gcggtcgccg agctcgcgga
     2761 cgaggacttc acgcggccgt ccggctgtgc cggctggctc gtccgggacc tggtgtgcca
     2821 cctggtcatc gacgcccagg acgtcctgat cacgctcgtg accccggccg cgaccgcgcc
     2881 cacccgcgac gcggtgacct actgggaggt ctcccggacg ccgccgaccg gcgacgaccc
     2941 gctcgacgcg ctgacggtcc ggctggccgc cgcctacgag gagccccggc tgctgaagtt
     3001 ccacctcgac gacgtcggct ccgccgccgg ccgcgccgcc gagctcgccg atccggacct
     3061 gtgggtcggc acccgcggcc aggtcatcac ggtgcgggac tacctctccg cgtacgtcat
     3121 ggagtggacc ctgcaccatc tcgacctggt cgcgcacctg ccgggcgtcg caggaccgcc
     3181 cgccgaaggg ctcgcccgct cccgcgagac gctggaggag atcgccggga ccgcgttccc
     3241 cgcgtcgttc tccgacaccg acgcgctgct ggtcggcacc gggcggcggg ccgcgaccgg
     3301 cgcggagagg gccgagctcg gcgagctggc ggcgagggtc ccgttcgtcc tcggctgacc
     3361 ggcgcccggc gtggccccgc cggcgtcagg tccgccggcg tcaggtccgc cggaccgcgg
     3421 cgacgtcgag ctccagcgtc accttcggtc tgaccatgac ggtggtcgcg gcgttccagt
     3481 tcacgcccca gtcgttgcgg tcgatcgtga cggcgcccgt gaagcggacc tcggcgtcgc
     3541 ccggcgtgcc ggtcagttcg acgtccacgg tgaccggctt ggtcacaccg cggatggtca
     3601 gggcgccggt gaccgtgaag ctcctccccc cgaggtggcg cacctcggtg gaggtgaagg
     3661 tgagggccgg gtgctgcgcc acgtggagga acgcggcgcg cacctgctcg tcacgccgcc
     3721 ggttgccggt ctggaggctc gcggcccgga tcgtgagccg gacgccggac ctcgacgggt
     3781 cgtcgccgtc caggtgcgcg ccgccctcga actcctcgaa ccgcccgcgc acccggcttg
     3841 ccatcgtgtg cttggcgacg aagccgatcc gcgtgcgggt ggggtcgagg acgtagtcgc
     3901 cggtcagttc gctgaggggg gtcatggtgg gcatgcctgc tcgctccaga agatgggttc
     3961 gtctcacctg tacgacgagg caggccccgc gaatgtgagg ccgtgccgcc ggtctcacat
     4021 tccggggcgc tgtctcgtcg tacaggtgag agcactcgtg acaaaggaaa gccggcgaca
     4081 ccatgagcat cccttccgag cccggagacg gccggctcga cccgggcctg agcgcgatcg
     4141 tgagcgagcg ccgccagctg atcaatctcg cctaccggct gctgggctcc ctggccgacg
     4201 ccgaggacgt cgtgcaggag acctacgccc gctggtacgc catgtcgggg gcgcagcggc
     4261 aggcgatcgc gtcccccggc gcctggctga ccacggtggc cggccgcatc tgcctcgacg
     4321 tgctcggctc ggcgcgggcc cgccgcgaga gctacgtggg cgagtggctc cccgagccgc
     4381 tgcccgaccg tacggagtgg atcgaggaac ggccgggcga caccacggcc gacccggccg
     4441 accgggtcac cctcgacgag tcggtcaaca tggcgttcct cgtcgtgctg gagtcgatga
     4501 ccccggccga gcgggtggcg ttcgtcctgc acgacgtctt ccgctactcc ttcgccgagg
     4561 tggccgaggt cgtcggccgc agcccggcgg cctgccgcca gctcgcctcc tcggcccgcc
     4621 gccgcatccg cgacgcgcgg accccggcga cgccagccgc ccggcgggcc ggcgtcgtca
     4681 gggacttcaa gcaggcatgg gaggccaagg acatcgacgc cctcatcggc ctgctcgacc
     4741 cggaggccac ggcggtcggc gacagcggcg gcctcgtcag cgccgtgctc gacccagtcg
     4801 agggcggcga gcggatcgcg cgctacctga tcgaggtcat cggcatggcg cccgacctgg
     4861 cgatcctgga gcggacggtc aacggccagc ccggtctggt ggcgcagcgg gagggcctca
     4921 tcgaggcggt gttcgcgttc gacgtcgccg gggaccggat cacccgcatc tgggccgtgc
     4981 gcaaccccga gaagctgcgg ccgtggacgg ccggctgacc cgccggccgc gcgacgacgc
     5041 ccggacggcc cggccggtga ccccgccgtg cccgggtcgg ttcgccaggc tcccgaacat
     5101 gccgtgctcg taggcgccgc cctgggtgcg cacgatcacg ccgagccggt cggccgcgtc
     5161 gatcatggcg ttcaggtgga ccagcgcggt cgtgtgacgt acgccaccgc gcgcgggtgt
     5221 cacaaaaggc cgggtgccgg cgtcctgtgt gcggcacggt cgagagccca cagacaggag
     5281 ccagcccatg aacgagcgca gcgagccgac ggcggacaca tcggagccgc tcgccggcga
     5341 ccgccgcacg gacgccgcca ccgaggcgtt cgtcacccat cgcaacctgc tgttcaccgt
     5401 cgcctacgag ctgctcggct cggccgccga cgccgaggac gtcctgcagg agacctggct
     5461 gaagtgggcg ggcgtcgagc tcggcaccgt gcaggaccag cgcgcgtacc tggtccggat
     5521 caccacgcgc caggcgctgg gccggctgcg cacgctcggc cggcgcaagg agtcctacgt
     5581 cggcccctgg ctgcccgagc cgctgctgac cgcgcccgac gtggccgagg acgtcgagct
     5641 ggccgacagc gtgtcgatgg cgatgctgct ggtgatggag accctccagc cgaccgagcg
     5701 ggcggtgttc gtgctgcgcg aggtgttcga cctgtcctac gacgagatcg ccgaggccgt
     5761 cggcaagagc ccggccgcgg tccgccagat cgcccaccgg gcacgctcgc acgtcgccgc
     5821 ccgccggcca cgggggctcg tctccccgga cgagacccgc gacgccctgg aggcgttccg
     5881 gcgggcggtg gagaccggcg acctgcagcg gctgctcgac atcctcgcgc cggacgtcgt
     5941 gctcctgacc gacggcggcg gggtcgtgcg ggccgcgctg gccccggtcg tgggggccgg
     6001 cacggtggcc gacctgatgg gccggatcaa cgccgtggcg tcgctgcacc cggcgcaggt
     6061 caacggccac ccggcgctga tcgtccgggt cggcggcgag gtcgacaccg tcatggcggt
     6121 ccgcgtcgag gagggcctca tcaccgggct gtacgcggtg cgcaaccccg cgaagctgtc
     6181 gcgggtcgag caggagatcg ccctgagccg ctgagcccgg ctccgctccc cgcaggtggc
     6241 cggctagacc gccgcggcga cggcggcggc gatgaacagc acctgcaggg cggtgcggat
     6301 cggcagcggg gtcacgggct tcccggccag ggtgaggccg cggcgggcgg ctgagacgtt
     6361 ggccgggaac atggcggcca tgagcagcgc gagcccgatc gcggcgaacg gcgccagcgg
     6421 cgcgatcagc agcccggcgg cgccggccag ttccagcacc ccggtgaggg tgaccagcag
     6481 cgccggacgc gggaacaccg gggggatcat cgcgacgaag tcacggcgcc acgagggcac
     6541 gaagtgcggg atcccggtgg tgacgaacat cagggcgaga gcgccccgca gcgcgggctg
     6601 ccagctgtcc aggacctcga tgccggccag gccgagcacg cgcaggacga cgaagccacc
     6661 gatgagggcg atgaacggag ccatcccccc tccaatcttg ccagtggaaa gaaactagtc
     6721 accggagaga gtgcgggacg ttcgccattt tgtcaatgtc aagatagggt ggtgccgaca
     6781 acgacgatca tgggagtgcg gaggtgagac cgatcaagca gaacggctac caccacggca
     6841 acctgcggcg cgccgtcatc gacgccgccc tggaggccat cgccgagtcg ggccccgccg
     6901 gctggagcct gcgcgagctg gcccgccggg cgggcgtctc gcacgccgcc cccgcccacc
     6961 acttcggcga caagacggga ctgctgaccg ccgtggccgc cgagggcttc ggcatgttcg
     7021 ccgacgccct ggagcgggcg gccggcgacg cgctggaggt cggggtcgcc tatgtccgct
     7081 tcgccgtcgg ccatcggccc tacttcgagg tgatgttccg gcccgagctg taccgcatgg
     7141 acgatcccga cctggcgacg gcgcgcgaac gcgcggcccg cgtgctcgtc accagttccg
     7201 gcacgctgtc gcccgctccg gcgcaggacc gtctgaccac gatcgccgcc tggtcgctgg
     7261 tccacggctt cgccggactg tggctgagcg gctccctccc cgaggccgcc cacgaggacc
     7321 cggaggccct ggcccgctcg gtgatccgcc tcttctccgg gatgtcctcc ccgggatgag
     7381 gtcactcccg cgcgagcggg cagtgcggcg gatccttccg cgcggggtgc gcgccgcgca
     7441 ggaaggccgc ggtcgacatg gcgtacgcgg agcagacgag cccgtccagc cgcgtcgccc
     7501 cgccgtcgcc gaagcgccgg gtgggcacgc ccatggcgtt caggccgtgt tccaggtcca
     7561 cgctggagaa cgcgaccacc gtgtcaccgt gccggtcgac ccagccgaac acctcccgca
     7621 ccagcgcgcg ggccagggac ccgagccccg tcgccacggc gccggaccag gggcggtcgg
     7681 tggccaggcg gctggcctcc cacacggccg gatcccgggg cgccgggacg ccccgtaacg
     7741 cctcggggaa gacgtcacgg agcatgtacg ggccgtcggt gcgcagcaac cggcagcagc
     7801 ccgtcacctt ccggccggcc tccgcgtaac tgatcacgta gaccgggtcg cagtcgtcga
     7861 accggtcgcg ttccctgccg tcgcggctgt cgacgtccca gcgcagccgt tcgtggaaca
     7921 ccgcgtgacg cagccggaac atgccgtcga gcagccacgg cggcagctcc cccgcccggc
     7981 cgaccacgat ccgtcgcgcg cacccgtcct ctggcgaacc gtccacgagc atcctccgcg
     8041 tccgagccgg cccctcagcc gatcacctgt cgcctgttgt tcgccggacc aagagcgttg
     8101 gacgacgcgg accgccgcgt catcgcgcgc tcgtccgggc gccacgcagg aacagggcgc
     8161 tggtgaggac gccgaggagc acgatggcgg cgttcacccc gatcgcgacc ttcagaccgc
     8221 cgaggatggc cgaggctccg gtgccggcca tggcggcggt gacgacggcg ctcatgatcg
     8281 gcgtgcccat cgtgatgccg acctgctggg tcatggtcgc gaggccggcg accaccatga
     8341 gccacatcca cgaggggtcg gcgccgaggc cgagcagggc cgcggcgaac acggtctgca
     8401 ggacgccgcc cacgatcagc gtgccccata ccgccgagcc gggctcgccg tcggaggcgg
     8461 cactgcggct cctgggcagc gcgacggttc cggcggcccg gaacacgacg cctccggacg
     8521 cggcggcgtc accgtgccgc cgcgtcaccg ccccggcggc acggtgacgc cggggcggca
     8581 gggcgctcag gccgtcgcct gtctcgtggt gcccaccgtg cggttcttgt cgtcggtgat
     8641 gaccagccgg acggtgtagg tgcccggtgc cgcgtaggtg tgcgcggcga tccggtccgt
     8701 ggacgtgccg ccgtcgccga agtcccagga gtacgcgacg acggcgccgt ccgagtcgat
     8761 cgagtcggac gcgtcgaact cgcactgcag ctccacgcag gtgtaggaga tgatcgcccg
     8821 gtactcggcg ccgtcgcccg ccgcccggat gtcgacctgt gtcgtcaccg tcgtcgccgc
     8881 gccctggtcg tcgaccaacg tcactttgac ggtgtaggag ccggcgcccg cgtaggtgtg
     8941 caccgcgttc cgcgcctcgg tgtcggtgat cgtcgttccg tcacccaggt cccactcgta
     9001 gcgcacgatc tccccgtcgg ggtccgacga ctgggcctcc agtccgcacc accgcgtcgc
     9061 gtcttcgcag ctggccacga tcctgccggt gggcgccgcg tcggtggtgt cgacggtgag
     9121 gctcttcgtg gccgtcgagg acagcccgcc gtcgtccacg accttgagcg tgaccgggtg
     9181 cgtacccgcg gcgaaacggt gggagacccg cacccccgcg cccgcggccc cgtcaccgaa
     9241 gtcccactcg tacgtcgcta tggccgagtc ggggtcggtg gcgaaggacg cgtcgaaggt
     9301 gcaggtcagc gtgctgttga cgcaggcggt gctgaacgag gcggtcgggg ggacgccgaa
     9361 gtcggcctcc tgctgggtgg agctggagag gttcttctcg ttggtcacga cgagtccgac
     9421 gatgtacctc ccgctggtgc cgtaggtgtg cgaggccgtc gccccggacg cgctcgcgcc
     9481 gtcgccgaag ctccaggagt agccggtgac gttcccgccg ccgcctcccg tggacgtcga
     9541 ggcgtcgaac gtgcacgcct tggcgggctt gtcgcaggcg acggtgaagc gcgcgacggg
     9601 actgtccggg ccctgggggg ccacctcgtc cgagacgccg gggtccggcc ccgcgcccac
     9661 cgcgttgacc gcgacgacga acagccggta cgtccggccg ttctccagcc ccgtcaccgt
     9721 ggccgtcgtg gcctcgccgc cgacctcgac ggggtcaccg gacggctcgg gggtcacccg
     9781 gtacgcggtg atcgcggcgc ccccgtcggc cggggccttc cacgtgacgg cgacctgccc
     9841 gtcgcccgcg gtcgcccgga cgtccagcgg cgccccgggc gcctgcggcg cggcgaagta
     9901 gccgtagacg tcggcccaga cggtgacggc ggagcttccg gcgttcctga tcgtgatccc
     9961 gccgtccgcg ccgaccttca ccggcacgta ctgcgcgtag gggtcggtgg gcaggtagtc
    10021 gaccgatccc ccgcccggtg ggctgctctg gtcggacggg tggacgcgca ggctgccgga
    10081 gccggtgctc ttggccgtga agttgatccc gaccgcggtg acccccgtgt cgggcacccc
    10141 gccttcgccg agtggtgcga gggtggccgt gccgttggcc gggatggtga tcgccgaggc
    10201 gatccgtgcg ggagcgacgg gcacggccgc cgagccggcg gcggccgagg ccggcttgcc
    10261 gaagtatccc gacacgtcgg cgtagacgtc caccgccgcg gtgccgacgt tcgtgagcgc
    10321 gatcttgccg tcggcgccga gcgtgccgaa gaccatgttc gacaggaact ggttcgcccg
    10381 gtagtccagg acggtgtcca ccggcgccgc cgaccccgac gggtacgctc ggatcttccc
    10441 cgcggcggtg cccttcgcga ccagggcgaa cgccacggcc gagacgccgg aggcgggtat
    10501 cccgcccagc cccagcggcg agagcgtggc ggtgccgttc gcggggatgc tcaccttgga
    10561 ggccacccgg gccgtgttca gcggcacgta cgtggatccc gccgagccgc ccgccgcggc
    10621 cagggtgtag ccgtggacgt cggcgtagac cttggcggcg acctggccgg tgttggccac
    10681 cttgacctgc ccgtccgccc cgaccttcac gagcatcagc tcatggttgt acacgttggc
    10741 ctggtaggtc gccccggtca ccccgggctg cgaggcgccg gacgggaaga cgaccaggcc
    10801 gcccgctccg tccgttccct tgaccgcgaa gttgatcgcc gcgctcgcga cgcccgcggt
    10861 cggcacgttg ggagctccgg cgatcttcac ggtgacggtg gtcctggccg cgatcgtcac
    10921 gccgtccatg acccgcgcct tcgccgggaa gtactgcccc gggccgggct gaagccccgc
    10981 cgcggccagg cccgggcccg tcggggctga gtccgccacg cccggcgccg cggcccggac
    11041 gaggcagagc gacaccagga gcgagagcag gagggtgagg agcgcggcgg cacccgggcg
    11101 cgccgcgcgc ccgccggccg tcattgcccg ttccacggcg tggtggtggt gaacatgtag
    11161 acctcctggg cgtagggcgg ccaggtgttg tttcctccca tgcagtagcc gatgagctcc
    11221 ggatttccgt ggacggcgaa gtcgtactcc atcgacacgt tcgacgacca gccgctcgtg
    11281 gcgcccagca tgaggcccgc cacattggcc gccgcggtgt acttcctgtt ctcgcccctg
    11341 gtcttcttga gccccgagtt gtgcttgaaa tagcaggcga cgtggctcat gcagctctgg
    11401 ctctcacatc cgttgaccca cgtcgaatag ccgtacagcg tgcccgtcca gcgggtcgcg
    11461 acgcgcttcg tgtaggcgac gggaaaggtc gtgccgatcc attccagccg gtcctcgtag
    11521 tccattccgg cttccatgta gcgggccgcc ggcttgttca ggccggggtc gagggtgtac
    11581 ggcacctcgt atcccacgtc gttgccgatg tgcttggagc cgcccatctt ccaccggccc
    11641 tcttcgaact ccaccccgac ctcgacctcg gtgtccgccc gcctgccgta ggtgaacttc
    11701 actttggtgt tccgcgcgac ctcgatccgg gcgaccgtgg tcgggacgtt gctgtagcgg
    11761 gcgagcacca ccgacttcat cgacaccttc tcggccggac ccgccgcgcc cgcggcctgg
    11821 gacgcgcgcg cggaggcgag gagttcggcg gcacggcttc cggcgggagg cgtgaagggg
    11881 cgttgatcgg ctttcagcgt cacgacgtcc cgggcggccg acgtgtggga aggcgcgatc
    11941 cactgcccgc cggtctcccg ccggcgcgag aagaactgca cgtcgaactt cccggcgcgg
    12001 ctgaccagcg ccatgtagtt gctccatccg tcatttccgg acgcggcggt ctttcccgcg
    12061 ttcagcggca tcgacagttc gaagcggccg tccgggttcg ccttcgcgtg ggcgacggaa
    12121 tcgttgtgct cgctctcctc ggtcacgtcg aacacataga cgtccgctcc cccggcgggc
    12181 gccccggtcg cgtccagcgc cttgccggtg aggaacaccc cgctgtccgc cgacgcgcct
    12241 gccgcgggga tctgggtcgc cgtcgccagc agcacgaaag cgagcaccgc ccgcatcaag
    12301 gtgcacgccg gacggccggg gctcgggcgg cgttcggtga gggccaagaa ccacctccgt
    12361 ttcgaaaggg gtcaaaccgg agtcagtctg ccggtgggcg cagatgtccg acagacgctt
    12421 ccacgtacgt gcaaaagtgc tggtcccctc gccagggcgc accacaggcg ggggtccgct
    12481 tgacagtata gttatgcaca taactattat gcggataacc aatcccgggc atcgaggagt
    12541 caggcatgac cgtgaaggtc gccatcatct actacagctc gacgggcacc gttcactcac
    12601 tcgcgcgggc cgtcgccgag ggcgccgcct cggcgggagc cgaagtgcgc ttgcggcggg
    12661 tcgccgagct ggcgcccgac agcgcgatcg accagaaccc gtcgtggcgc aggcacgccg
    12721 acgccgcccg ttcgatcacc gaggcgtcgg tcgaggacct ggcgtgggcc gacgcgttcg
    12781 cgttcggtac gccgacccgg ttcggcgggc cggccgcgca gctcaagcag ttcatcgacc
    12841 aggccggcgg gctctggcgg gacggacaac tggcggacaa gccggtgacg gccttcacct
    12901 cggcctacaa ccggcacggc ggcagcgagg ccacgatcct gtcgctggcc aacgtcttct
    12961 accactgggg agcgctgatc gtaccgaccg gattcaccga cccggccgtg tacgccgccg
    13021 gcggcaaccc ctacggcacg tcgatgaccg gcccggccat ggacggcgcg gacaccgcga
    13081 cgctggaagc cgccaggtac cagggacgga ggctggcccg gatcgcgatc cggctgctgg
    13141 agggcgaccg caccgccgag gacaccccac cggacgggaa cgcccgcgaa gccctggccg
    13201 cgacgacctc tccgagcgcg tgagcggcgg cgtccggcca ggaggaaagc catgacgagc
    13261 gtcaacaccg cacctcagcc ggtcaggccc cacgcccttc ccgcctggat gatcaccgcg
    13321 ctggcgtgcg cctgccagtt catggtcatc ctcgactcgt ccatcgtcaa tctcgccctt
    13381 cccgcggtcc gcgaagaact cggcttcacc cctaccggcc tggcctgggt ggtgaacggc
    13441 tacctgctca ccttcgccgg cttcatgctg ctgggtggtc gcgcggccga cctgttcggc
    13501 ccgcggcgga tgctggtcgc cggtctgtcg ttgttctccg tctcgagcct ggtcgccggc
    13561 ctggcgaccg ctccgcaggt gttggtcgcg gcccgcgtcg cgcagggcgt cggagccgcc
    13621 atgatggccc cggccacgct ggccgtgatc aacacctcct tcaccgagcc gaacgcccgg
    13681 gccaaggtgt tcggcgcatg gtccgccgcc ggcggtgtgg gcgggatggc cggcgcgatc
    13741 gcgggcggtg ccatcaccac cggtctgtcg tggcgatggg tcttcctcat caacgtgccg
    13801 atcggcgcgg tgctgatcgt cgtggccctg atggcgccgg ccggcacccg caccgcccgg
    13861 cgcgagtcgc tcgacctcac cggcgcggtc accgggacgg cggggctggc cgcgctggtc
    13921 tacggggtca tgcagagcgc cgaccacggc tggacgtcgg tgccggtcgc cgggccggtc
    13981 gtggcgggcc tgctcctcct cgtcgtcttc ggcgtggtgc aggcgcgcct cgccgcccgg
    14041 ccgatgatgc ccctgcggct gttcagggcg cgcggggtgg ccgtcggcaa cggcatgctg
    14101 ctgctgttcg gcgccatccc catcgcgatg tggtacttca cgtcgctctt cctgcagaac
    14161 gtcctcggcc acagcgccct gcaggccggg ctcgggcaga cgccggcggc ggtgacgttc
    14221 ctggtgatcg cgcggtgggc cgcccccctg ctgccgcgaa ccggtgtgcg gcctctggtg
    14281 ctggccggca gcgcctgctt cctggccggt ttcggctggc tcgcccaggc ccaccccgac
    14341 agcgggtacg tcaccggggt gctcgggccc acgctgctca tcgcgaccgg catcgggctc
    14401 accttcccca ccctcatggc cgcggccacc gccgacgtcg ccgaaggcga cgcgggcatc
    14461 gtcggcggtc tggccaccac cgcgagccag gtgggcggct cggtgggcct ggcggtgctc
    14521 gcgacggtcg ccggcgccag agccgcgtcg gaggccggcg cgagttcctc gcccgccgct
    14581 ctcgccaccg gctacgacct ggtcttcctc atagcagccg gactcggcct ggccatcgcg
    14641 gcggccagca tgctgctgcc acggcaccgc cgcgactgac cgcccgcgac tgaagcgctc
    14701 gcccgtctga aggtcatgcg ctcactcgca ttcctcgccc tcatcgtgct gaccgcctgt
    14761 ggcagcggag tggcggccgg caagccggtc acgtacgagg ccgacgacgt ctccgttccg
    14821 tcccggaggg cggctggcgg ccggccgatc ccgccaaggc cacccaggaa gcgctcgagg
    14881 cgactcagca gcggctggag gacgaggccg ccgtgggcgg ggtgtggctg gaccagagct
    14941 atgtgagctc gatccccggc tacgacgaca gcaagcggga gtggtcggag aagtatgcca
    15001 acgacccggc caagctggtg ctgaacgtga agttcacggg tgacctgacc ggcagggagg
    15061 cgtggattcg ggagagctgg ggcggcgcgc tctgtgtgag ccaggccagc ccagcccttc
    15121 acctcgacct ccgtcgacat catgaaggag caggtggtcg tgggcgtctg ggtggccagc
    15181 gagaagctcc agcaacggct ggaggacaag tacggcgagg gcgtcgtact tgtacagccg
    15241 gcactgacac cggtgcaata gcgaagccgt ggccacacgc ctccagccag tgaccgcgct
    15301 gacgcgctgc cagagagttg acacgttgtc gacccccagc ccggcacgca ggggtgtgcc
    15361 tgcagggcgc tgtggcgcca accatcttga tggcagccga ctccgagttt cctcctgagc
    15421 tcgtcgataa gcaggttgcg ctctatgccg cgatagacaa ggtggcggaa atcgtggccg
    15481 ccgagccgaa gccgcctgag ggcgaagcgc taacggcgga gcagcggcag gcgctagatg
    15541 atgcgctggc tgagcaccga gtggcgctgg agcaggcccg cgctacgcaa agtaaggcgc
    15601 tcgatgaaga atcaaagccc aattcgccga gcaccccccg acagcggtta ccggtctatc
    15661 gactgagtcc ccgcacgtag cgagcggagg gttccggagc cgaggaggtg gggttcggct
    15721 actcgtgagt catgatggcc aacctgcgcc gggcctcgac acggtcctgc tccagcgtgc
    15781 aggtcagccg gccgtgcagg ccgatgcgcc acaccagtgt cgctcgaact cgccgtaagc
    15841 aggaggggcc tcgctggccg ggctcgaacc ggcgtccacc cggtcccgag ccgggcgctc
    15901 tacctctgag ctacaacgag gccacgtcca ggcgccgccg accgggctcg aaccggcgac
    15961 cacctggaag aagagccagg cgttctacca ctgaactacg gcgggccgcc tccagtgtgt
    16021 ccgatagctg ccgggcgggg ccaccctttt tgtcgtcggc ggcccccgcg gctttcactg
    16081 tggcggacgg tctgccgcgg gcaggtcgct gaccacgacc ccggaaacca gcccatggca
    16141 ggcgtcggcg gccagctctg gcttgagagg cttgccgctg aacgctcccg cccgtcgcaa
    16201 cagcgacgcc cagactgggt ctgcgacgct caccccgtgc accagttcgg gcgtcggccg
    16261 gaacacggcc gcaccccgcc gagccgccgg cgcagtccac ccgcacttct ccgggtccag
    16321 cccggccgta cggcaggccg cctcgacgtc ggcgcgtgtg ctgacctgga tcccgtccaa
    16381 aacctcccag ggcggcggca gcgccgccca caccgcggtg ttgggatcga cgtcgctccc
    16441 actgctctgg tgccaggcgg ccaggtcggc cgccatcagc cgcatcgcct tgccgggaca
    16501 ggccacgtcc agcaggtcga gggcgtccag cgaggccagg caggccagcc aacccgcccg
    16561 agcggcgttg taggcagccg ccaggttgtt ccaggtgctc gagtcgtcgc cccgccgtac
    16621 gatcatcgag gtccggtcgg tggcgggatc ccagcggtcg cggagcatgc cggcgctgtg
    16681 ccgcatgacc gccgaccact gcccgagcag ccgcccccgc tcctcttcgg tgaggtgctc
    16741 caggacgtca ggcgttgtcc gcacctgggc gatcatccac cagtcgctgc cgtccgtgca
    16801 ccggtcgagc aggatggagg cgatctcgtc gaacgggttc tcccgccccg acaggctgaa
    16861 ctcccggcgc agcttgcgcc gggcggtgta gtaggcgacg aagcaggccg cgtccgggtc
    16921 ggccagaaag cgctcacgag ggatgccggc gccgaaccct gtcacgccca ccatgagcag
    16981 ccgccgcttg tcctgctcga ggcccagggt gccagccttg gcggcgagcc tgcgcagcat
    17041 gcggaagcgg cggttgtact gccgcttgga cagctccata cccgcctcgg tgcgggactg
    17101 ccggttgagc cggtcggcca ggaagtcgct ccggtccggc gcccacctga tcgcgtcccc
    17161 catggtggcc gcgaactcca gcaacgactc cggatcgtcg gggtcgacct cgacggaccg
    17221 ctcgaacagc cgagtggccg ccgcgacctg ccgcgccccg ccaaccggcc ggacgtagtc
    17281 ggcggacatc gaggagaacc atgccgtctt acgcgaggag tgcttggccg cacgtcccag
    17341 caccacccgc tcacgcctcg acagccgccc ttccagcgcc tgcagcacca ggtcggcgac
    17401 gtcctcaggc cggtagcgtc gatccagcga gtcgtgcagc tcgaccagga tctcgtgatg
    17461 agagcgatct gggtccttgc ggaacttcat gaccgccatc attgccgcca ctccccgtcg
    17521 acttcgaccg gatttcttta cccggtcgcg tgctctttcg cgatgagtgt gtgtcgggcg
    17581 gcttgtgtag tgcgcgctcc gtctcggtgt ggcagccgag caatcggtga tcagaggggc
    17641 cgctgcgatg tcgatgatct cgctcgtcac tgctcgagag cgtctttcat gcattttggc
    17701 atgggtgccg taacggcgcc tctccccgtg cgtatgggcc aatgtgggcg tcagaagaca
    17761 gccgtcaagc ggggcaatct gcggttgatg ccggtagggc gggcgctcgc cctcgtggcc
    17821 ggcgctgcgc tcgtcctcct cacgaaggtg atcgtcgtcg tgttggtgtt gctcggtgcg
    17881 gaagggctga aacctgaagc acaggtcagt acggctaccc tcttcgactt gttgaagatc
    17941 gctttggcgg tggtggcgct ggtgatgggc taccggcggc agaaggttgc tgaggcggct
    18001 cagcgggtca gtgaacgcgg cgagga
//
