LOCUS       NZ_JABWGO010000007     26194 bp    DNA     linear   CON 29-SEP-2024
DEFINITION  Nonomuraea rhodomycinica strain TBRC6557
            NODE_7_length_433869_cov_25.3555, whole genome shotgun sequence.
ACCESSION   NZ_JABWGO010000007
VERSION     NZ_JABWGO010000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nonomuraea rhodomycinica
  ORGANISM  Nonomuraea rhodomycinica
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 433869)
  AUTHORS   Chanama,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUN-2020) Microbiology, Mahidol University, Faculty of
            Public Health, 420/1 Ratchawithi Road, Ratchathewi, Bangkok 10400,
            Thailand
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2020
            Assembly Method                   :: SPAdes v. 3.10.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013363995.1-RS_2024_09_29
            Annotation Date                   :: 09/29/2024 04:09:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,940
            CDSs (total)                      :: 8,866
            Genes (coding)                    :: 8,758
            CDSs (with protein)               :: 8,758
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 63
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 108
            CDSs (without protein)            :: 108
            Pseudo Genes (ambiguous residues) :: 0 of 108
            Pseudo Genes (frameshifted)       :: 12 of 108
            Pseudo Genes (incomplete)         :: 99 of 108
            Pseudo Genes (internal stop)      :: 6 of 108
            Pseudo Genes (multiple problems)  :: 8 of 108
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:20:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 185587
            Orig. end                         :: 211781
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JABWGO010000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26194
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26194
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26194
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16194](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16194)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(561..574)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.09"
                     /tool="antismash"
     gene            complement(582..1541)
                     /locus_tag="HT134_RS27055"
                     /old_locus_tag="HT134_27040"
     CDS             complement(582..1541)
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540315.1"
                     /locus_tag="HT134_RS27055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27040"
                     /product="M23 family metallopeptidase"
                     /protein_id="WP_175603271.1"
                     /transl_table=11
                     /translation="MKLNGALITGFALLVSLGTGTAAFADPAPSPTASPVPAPTSTATA
                     ETATTLAAPTFQLPFPCGQSWTGDSSGSSAHQSYEIDFNRGGTPDADLGDTVVAAASGT
                     VVISAHQGSANGFGNLVKIDHGDGYATYYAHLNSRTVSAGQSVSQGQPVGTVGNTSKPG
                     NDITPHLHFEVRRGTSYPANIQKAVFDGVTFGYPVQTVTSRNSCGGGTTNPHTAESVCG
                     SGHKVIDSAPLGSDGTVYLLYNSSTGKNCVATIKSTSVGTATAVSAYLEVAGAARQTDT
                     GNFAYYAGPVTASAAGKCVRWGGSAGSTTYNSPSEHCG"
     misc_feature    complement(1500..1502)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1655..4330
                     /locus_tag="HT134_RS27060"
                     /old_locus_tag="HT134_27045"
     CDS             1655..4330
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540314.1"
                     /locus_tag="HT134_RS27060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27045"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_175603272.1"
                     /transl_table=11
                     /translation="MTVTFHVLGPLEIRTSGQPVRISGKKPRLLLATLLLEAGGVVGAD
                     QLVEVLWPERPPRSAQANLRTYVSSLRTDLGEDGRCLRGNGSGYAIDVPEGALDLLVFE
                     ELVGQARYEEALSLWRGAPLADLPGSPLWDRRLDPLHEVRLRAAEELISRRMDQGDHAG
                     AVSELRGLLAEHPYREDLWGRLLLALHRGGRKAEALRAYATVRQLLVDELGVEPGTGLR
                     AAYESILADEAPPAAPRQLPPDVPDFTGRADALAALNEPFQVAVISGRPGVGKTALAVH
                     AAHALREKFPAGQLHLDLDGREPADLLAEALRALGADTPPPTVHERSALLRSMLAERPM
                     LVLLDDALDASQVRPLLPGNDSVVIVTSRRRITELPGSRHIDLGELPVDDALQLLGRIV
                     GPDRVAREQEDARAIVAACGGLPLAVRSAGARLAGRPGWSLAVLRQRLEDDRLNELQEV
                     RVCLDRSYRDLPDEAARMLGTFGRLGALAQPGWVVDAALDRHRADDVTDLLVDVNLLEL
                     VGTDPVGQPRYRVPDLIRRHALERTPDRDALGRVLAAWTATTEHAMARLPTTVFSLTAP
                     RTPRWRLPEQTLERLTSNPLGWFEAEHDSLVAAVGVAAEAGLAESAWGLAAAMVPYLDL
                     HCRLDTWQRTHSVALQAARAGGDTYGEAAMLRGLAQVALYQDRYEEAADGFLRSRRLFH
                     DLGDVRAEATTICGLGAVSQFRGRPAQSLGHFKRALAMFLAADDPQGEALARQAIGRVC
                     LKSGDLTQASESLAQAMRLAQELGDSHREGCVCLQMGQLHEAVSFHHHALDIFESLGDR
                     HCGAYALQSLARLQVRSGDLAPASTGLQRSLEVFQELGDRSGEMSSTQLLGELYRTAGR
                     TGLALDYLRQASDLRRRLPV"
     misc_feature    2207..2209
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4553..5899)
                     /locus_tag="HT134_RS27065"
                     /old_locus_tag="HT134_27050"
     CDS             complement(4553..5899)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540780.1"
                     /locus_tag="HT134_RS27065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27050"
                     /product="NERD domain-containing protein kinase family
                     protein"
                     /protein_id="WP_175603273.1"
                     /sec_met_domain="Pkinase (E-value: 1.1e-16, bitscore: 55.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQIVGGGRPVNDAERRVIAYLRDHAPAEWLLLHNVEVPRGDDVF
                     EVDLLVLTGHSLVVVDVKGTRGRIQVSGSRWFPPRREAFGSPVTKLRGTARALKGLLVS
                     RATQLERVYVDSIVVLTSPDAELVDPTGRDSAHVTDLAGLVPMLADASRVKRGCSPDAR
                     PYLTAILDALNQTVRRSTAPPRYGNWEVEEQLGGDTRVTEYRAFNATLPGSETVLLRVY
                     QADPLADEAARAAERQRIANAYQSLARIPPHPCVVRSRDFFAIDDESRFVLVLDDVHGE
                     ALHLSPGRGAGSPFVIPDLLSGLAHAHAHGVIHRALTPACVLVTDDGHAVLTGFDYSKP
                     GPRNFTVAHELSNVLDGHYAAPECQDRPDRMTAASDVYAAGVIAYQLLAGELPPGPDAL
                     GPEVPDVVRRMLDHSPAKRPSAAEALDGLRGIPQRSRLRRLVRRIVSGS"
     misc_feature    5952..5972
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.9"
                     /tool="antismash"
     misc_feature    complement(5955..5975)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            5960..6586
                     /locus_tag="HT134_RS27070"
                     /old_locus_tag="HT134_27055"
     CDS             5960..6586
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017592208.1"
                     /locus_tag="HT134_RS27070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27055"
                     /product="DJ-1/PfpI family protein"
                     /protein_id="WP_175603274.1"
                     /transl_table=11
                     /translation="MMKTKKPVHVGIYDTWADWEAGHAIAHLRAERFHREPGGYEIVTV
                     GLSTEPITTMGGLRVVPDLALEDLSPAASTMLILPGADLWDAGDALAPFARAARAFLDA
                     GVPVAAICGATAGLAREGLLDDRDHTSAALPYLEAQPGYGGAKRYLDRDAVTDGDLITA
                     GPTEPVAFAREILSRLDAYRPEVLDAWYRLFAKSDPSAFGVLMSA"
     gene            6952..7371
                     /locus_tag="HT134_RS44855"
     CDS             6952..7371
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621409.1"
                     /locus_tag="HT134_RS44855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_217708454.1"
                     /transl_table=11
                     /translation="MSAAALTAFRLNGQFLEVAEELARPAGLTAAWWQVLGAVLAEPLP
                     VAGVARVMGMTRQGVQRIADLLVERGLAEYRPNPAHRRAKLLQPTAAGRDAIALITPGH
                     RRFAGRLVARLGEAEARECLRALRLLSSALDDLSP"
     misc_feature    7512..7525
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.15"
                     /tool="antismash"
     gene            7670..7909
                     /locus_tag="HT134_RS27080"
                     /old_locus_tag="HT134_27065"
     CDS             7670..7909
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HT134_RS27080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HT134_27065"
                     /product="hypothetical protein"
                     /protein_id="WP_175603276.1"
                     /transl_table=11
                     /translation="MIRRILAGAAIAGIAFGFSATAASADDTPYNSGNSVLSQFSALHN
                     ATVLNGVLNDSVKDIDVLNVGKLEEANVMVLNNG"
     misc_feature    8047..8061
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.91"
                     /tool="antismash"
     misc_feature    complement(8383..8398)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.06"
                     /tool="antismash"
     gene            8384..8944
                     /locus_tag="HT134_RS27085"
                     /old_locus_tag="HT134_27070"
     CDS             8384..8944
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HT134_RS27085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HT134_27070"
                     /product="hypothetical protein"
                     /protein_id="WP_175603277.1"
                     /transl_table=11
                     /translation="MMRRILVGAALAGAVFGLSTVSAHADSGTSALCTPKPVVTDCAPK
                     PVVLTPKPVIAVPCATKIVTTATQCTTTCTTKCVTNSGATQSSSTQSTQSSQSSQSSST
                     HSTATSSTATSSISYVPMSGPLNTGNQIGSQWSAANDLVLLNDVANNSVKHIDVLNVGK
                     LDKVNVGVLNNHQAAATSVLAPC"
     misc_feature    9453..9467
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            9585..10004
                     /locus_tag="HT134_RS27090"
                     /old_locus_tag="HT134_27075"
     CDS             9585..10004
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024857.5"
                     /locus_tag="HT134_RS27090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27075"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_175603278.1"
                     /transl_table=11
                     /translation="MSGDTDTNERLLYADRLVRISLRMPLRDPRTTPHLLFATAGTGPV
                     VTLVGEIDVSNCEALTRALTACRAGGGHVTVDTGRLSFIDLAGLRALIMPALPAPQRWV
                     RLRNVTPYQERLLQLIGWLYELDPEPDSAAPQATP"
     gene            complement(10001..12181)
                     /locus_tag="HT134_RS27095"
                     /old_locus_tag="HT134_27080"
     CDS             complement(10001..12181)
                     /EC_number="4.2.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017594229.1"
                     /locus_tag="HT134_RS27095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27080"
                     /product="terpene synthase family protein"
                     /protein_id="WP_175603279.1"
                     /sec_met_domain="T1TS (E-value: 2.5e-86, bitscore: 285.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADQPFELPDFYLPYPARLNPHLEEARRHSREWARAMGMLEGSGV
                     WEQRDLDSHDYALLCAYTHPDCDGPELSLITDWYVWVFFFDDHFLELFKRTGDREAGKQ
                     HLDRLPAFMPPDLAAGMPEPANPVEAGLADLWRRTVPSRSQQWRERFAESTRNLLNESL
                     WELSNINIGRVPNPVEYIEMRRKVGGAPWSAGLVEHAVGAEVPARIAASRPMRVLRDTF
                     SDAVHLRNDLFSYQREVEEEGELSNGVLVLETFLGCTTQEAADSVNDLLTSRLQQFEHT
                     VATELGPLFAEHGLDPLSCAGVLAYVKGLQDWQSGGHEWHMRSSRYMNERAGRGAGLGM
                     RAVVDILGAKRFRSYAHVPHRRVGPSVIPELLMPFEPRLSPHLGAARVNVITWAREMGI
                     LEAQPGVVGSAVWDADKLADYDLPLCAAGIHPDASPAQLDLSSAWLAWGTYGDDYFPVV
                     FGRTRNLAAAKVCVERLPMFMPLDGPPLAVPVNALERGLADLWARTAGPMEPAARRRFR
                     GAIEDMVQSWLWELANQIANRVPDPVDYVEMRRMTFGSELTMSLCRLAHGDRVPPEIYD
                     SGPLRSLENSAMDYAALLNDVFSYQKEVEFEGETHNVVLVTETFFGCRYPEALGIATDL
                     INSRMRQFQHVAEHELPVLYDDAGLSEEAREVLRGYVRDLENWMSGILVWHRDCRRYDE
                     ESLRRHHQPPRWRLAGPTGLGTSAAMMWGSAV"
     misc_feature    12162..12177
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.52"
                     /tool="antismash"
     gene            complement(12186..13667)
                     /locus_tag="HT134_RS27100"
                     /old_locus_tag="HT134_27085"
     CDS             complement(12186..13667)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619264.1"
                     /locus_tag="HT134_RS27100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27085"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_246365513.1"
                     /transl_table=11
                     /translation="MTEQQRDAARQSLGTEAVPQSLGTEAARLLATTTKTPPQAREITP
                     RWLTRVLPWVEVAGAVYRVNRRHTYPVGGGRVGFAFEGARVRVIPPSLAELPPLGGYDD
                     AAVLERLAGLFEQREYAPGEAVVRAGEPADGLVLLAHGKAVRLERGPYGDALVRATLSA
                     GDHAGAERSWAASLGAAERSGAGPSGAEGRWPYTLEARTPCTVLYLPWEAFDALADRSP
                     SLRARLDRHRAELARPRNKHGEAAIAVAAGHRGEPVLPGTFADYDPGPREYELSVSQAV
                     LRVHTRVADLFSEPMDQTEQQLRLTVEAVLEAQEHALVNDPGFGLLHNVDPRQRLPTRG
                     GPPTPDDLDELLSRRKKTRYFLAHPAAIAAFGRECNRRGVHPEPVTVEGRALPAWRGVP
                     ILPCDKLPVSRAGTTAILAFRTGEDDQGVVGLRQTGLPGERLPGLSVRRTGIDERAITS
                     YLVSAHYSAAVLVPDALGMLTDVQVHDQRFTSATE"
     gene            complement(13687..15093)
                     /locus_tag="HT134_RS27105"
                     /old_locus_tag="HT134_27090"
     CDS             complement(13687..15093)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619264.1"
                     /locus_tag="HT134_RS27105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27090"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_175603281.1"
                     /transl_table=11
                     /translation="MTETFESAPEGHNQQLSLSTEAARNLATTTKTVPQMQEITSRWLL
                     KLLPWVQTSGGVFRVNRRLTYTLGDGRITFTTTGAEVRVIPAELTELAPLRGFCEMEVL
                     EALAARFIQREYEAGQAIVTEGSPVDQLVLIAHGRVAKSGHGAYGDEQALGVLADGDHL
                     GEQLLTEPGRFSFTAKAATSCTVLVLSQHDFQQIHDQSPELRDHLAGIRDVENRARNDY
                     GEAAIDMSSGHTGEPTLPGTFVDYDLAPREYELSVAQTILRVHTRVSDLYNQPMSQLDQ
                     QLRLTIEALRERQEHELVNNRDFGLLHNADFSQRIRTRSGPPTPDDLDELLAKVWKEPA
                     FFLAHPQAIAAIGRECSKRGLYPQASEVGGHRVPAWRGVPIFPCNKIPVTDTRTTSIML
                     MRTGQESQGVVGLHQTGIPDEYQPGLSVRFMNINEKAVISYLVTAYYSAAVLVPDALAV
                     LEDVELGHEH"
     gene            complement(15196..16194)
                     /locus_tag="HT134_RS27110"
                     /old_locus_tag="HT134_27095"
     CDS             complement(15196..16194)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017541915.1"
                     /locus_tag="HT134_RS27110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27095"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_175603282.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.8e-51, bitscore:
                     167.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGFLEAWRAPVSDPDVVAAYELLTDFILSGGKRVRPQLCYWGWR
                     GAGGGDCDEIISAAAALELCHAGLLIHDDIMDGSELRRGHATVHRRLSQLHAGPGAETF
                     GQAGGILLGTLSLAWADALLSSCGVEPGRLRVAHHLFDAMRSEVISGQYLDILAQLRAG
                     ASVPESLTVIRYKTAKYTVERPMQIGGALAGAPPELLESYSRFGLPLGEAFQLRDDVLG
                     TFGSSAETGKSALDDLRDGKHTVLFAHAVQRATPAQRSYLRTWHGHPDLTEEQADELRQ
                     IIVATGALAEVEDMIAERVREATAELRAAPMTAEAREALAVLAERLAHRDR"
     misc_feature    complement(16230..16244)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.52"
                     /tool="antismash"
     misc_feature    complement(16427..16442)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.69"
                     /tool="antismash"
     misc_feature    complement(16432..16445)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.72"
                     /tool="antismash"
     misc_feature    complement(16474..16487)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.21"
                     /tool="antismash"
     gene            16483..17040
                     /locus_tag="HT134_RS27115"
                     /old_locus_tag="HT134_27100"
     CDS             16483..17040
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025013.5"
                     /locus_tag="HT134_RS27115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27100"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_175603283.1"
                     /transl_table=11
                     /translation="MRRSHLSLLIAAVAAAATAGCGGGVTDSSASSGAASSASAPAAQA
                     SGQDRAWMRQIHLGGLAELHAAKLAQDKGSQDVKALGDTLVRDRGTLDAQLVRAAERHG
                     VRLPTGLSTAQQKEAVALEKAGHARFDRRFVKEMAQSHRRAISSTKREIKKGSAPEIVS
                     LAKSTLPSLEHHLAMLREADSS"
     gene            17140..18321
                     /locus_tag="HT134_RS27120"
                     /old_locus_tag="HT134_27105"
     CDS             17140..18321
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0004024 - alcohol dehydrogenase (NAD+)
                     activity, zinc-dependent [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (127-257). E-value: 3.3e-07.
                     Score: 21.6. Matches aSDomain:
                     nrpspksdomains_HT134_RS27120_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016188395.1"
                     /locus_tag="HT134_RS27120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27105"
                     /product="zinc-dependent alcohol dehydrogenase"
                     /protein_id="WP_175603284.1"
                     /sec_met_domain="ADH_N (E-value: 4.1e-28, bitscore: 92.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.4e-15, bitscore:
                     51.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVTWHGKRDVRVEEVPDPAIKEPTDAIIKITSTAICGSDLHLY
                     EVLGPFMTQGDILGHEPMGVVEEVGADVEHIRPGDRVVVPFNIACGHCHMCGMRLYAQC
                     ETTQVREHGMGAALFGYTKLYGQVPGGQAEYLRVPQAHFGPIKVPEGPADERFVYLSDV
                     LPTSWQAVEYAEVPEGGSVTVFGLGPIGQMTARIARHRGYRVIAVDGVPERLEMARRHG
                     IEVVDARAADDVPDAVRGMTGGRGTDSVIDAVGMEAHGSPGAKLAQTLTGYLPDAVAAP
                     LMKQAGIDRLVVLNQAIDTVRRCGVISVIGVYGGMTDPLPMLRMFDKGVTLRMGQAHVR
                     RWIDDLMPLVTDDADPLAVMDLATHRLPLDEAPRGYEIFQKKQDGAIKVLLRP"
     aSDomain        17521..17910
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HT134_RS27120_PKS_ER.1"
                     /evalue="3.30E-07"
                     /label="HT134_RS27120_PKS_ER.1"
                     /locus_tag="HT134_RS27120"
                     /protein_end="257"
                     /protein_start="127"
                     /score="21.6"
                     /tool="antismash"
                     /translation="VPGGQAEYLRVPQAHFGPIKVPEGPADERFVYLSDVLPTSWQAVE
                     YAEVPEGGSVTVFGLGPIGQMTARIARHRGYRVIAVDGVPERLEMARRHGIEVVDARAA
                     DDVPDAVRGMTGGRGTDSVIDAVGME"
     gene            18358..19407
                     /locus_tag="HT134_RS27125"
                     /old_locus_tag="HT134_27110"
     CDS             18358..19407
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (58-214). E-value:
                     2.1e-08. Score: 25.5. Matches aSDomain:
                     nrpspksdomains_HT134_RS27125_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891984.1"
                     /locus_tag="HT134_RS27125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27110"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_175603285.1"
                     /transl_table=11
                     /translation="MKVVVVGATGNVGTSVVEALRTDDQVRSVVGVARRLPGWQPEKVE
                     WRRGDVVTDDLTPVFEGADAVVHLEWLFQPTRDTTVTWRANVLGAMRVFRAVAEAGVPA
                     LVYASSVGAYSPGPKDRAVDESWPTHGWPGAAYGREKAYVERVLDVFENDHPDIRVVRM
                     RPGFIFKRESATEQRRLFGGPFVPRRLVRPGLIPFVPDMPGLRFQCLHAEDAAEAYRLA
                     VVRQVSGAFNLAAEPPLDAAALARLLGARTVPVPPFLARTAMAAGWHLRLLPAAPGLLE
                     MLLQVPLMDVTRAREVLGWTPAHSSQEAMEAVVEGLHEGAGADTAPLAPDEGLAGRLKE
                     TTTGVGGRP"
     aSDomain        18532..18999
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HT134_RS27125_NAD_binding_4.1"
                     /evalue="2.10E-08"
                     /label="HT134_RS27125_NAD_binding_4.1"
                     /locus_tag="HT134_RS27125"
                     /protein_end="214"
                     /protein_start="58"
                     /score="25.5"
                     /tool="antismash"
                     /translation="VFEGADAVVHLEWLFQPTRDTTVTWRANVLGAMRVFRAVAEAGVP
                     ALVYASSVGAYSPGPKDRAVDESWPTHGWPGAAYGREKAYVERVLDVFENDHPDIRVVR
                     MRPGFIFKRESATEQRRLFGGPFVPRRLVRPGLIPFVPDMPGLRFQCLHAED"
     gene            complement(19416..19724)
                     /locus_tag="HT134_RS46005"
                     /old_locus_tag="HT134_27115"
     CDS             complement(19416..19724)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019351.5"
                     /locus_tag="HT134_RS46005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27115"
                     /product="multicopper oxidase domain-containing protein"
                     /protein_id="WP_312888464.1"
                     /transl_table=11
                     /translation="MKNGVPNPLLWGDPVTENPALDPTEVWELYTFTADAHPIHRSTAA
                     PRPPEPWERGFKDTVIAPPGEITRVKATFDLPGRYVRHCHILEHEDNEMMRPYQIIG"
     gene            complement(19841..20221)
                     /locus_tag="HT134_RS27135"
                     /old_locus_tag="HT134_27120"
     CDS             complement(19841..20221)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634938.1"
                     /locus_tag="HT134_RS27135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27120"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_175603286.1"
                     /transl_table=11
                     /translation="MPSTTRPGPAIRTLPEPAGLPEPLPEPAVEDLRLETVLGALSDPL
                     RLTIVRKLLLESEAFDHTCGWFGLDRPKSSLTHHFKALREAGVTRQRQYGLERRSHVRV
                     ADLEARFPGLLALVAAWTPDES"
     gene            20319..21590
                     /locus_tag="HT134_RS27140"
                     /old_locus_tag="HT134_27125"
     CDS             20319..21590
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634937.1"
                     /locus_tag="HT134_RS27140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27125"
                     /product="MFS transporter"
                     /protein_id="WP_246365515.1"
                     /transl_table=11
                     /translation="MSMSRAMPVRAPAERPGTAAAAVPTRWVWLAAWPVTAVFVLSNAA
                     TPLYVLWQRDIGFSKGTLTVVFASYIVGLIGSLLVSGVLSDRLGRKPVLLPALGLALAA
                     CLVFATAGSVAALIVARLFTGVAVGAVVSGGMAAVSDVAGPARSRLGALLASCAMVFGA
                     GLGPLLSGVLSEALPAPTVTVFAVEAALLATAVAVVLRMPVRRPAVPAQGAKGRARAAG
                     SWVRVPAVPRGNGRHLALGVAVFAPGITATSFVLSLGPSLLAGLLDGTNRIVPGVMAFA
                     MFLASTGVQFAVQRLRRGAILIAGAASTALAMVALVIAVRVASVEALAVAALLAGAGQG
                     MGQLGGLSLLNSTVPAGRLAEANAALNVGGYVLAGLLPVSAGYLSDAIGLTGGATLFGA
                     VLMGLAVTGGLVVVLGRRWVPEPR"
     misc_feature    21606..21620
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.53"
                     /tool="antismash"
     gene            21652..22140
                     /locus_tag="HT134_RS27145"
                     /old_locus_tag="HT134_27130"
     CDS             21652..22140
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540296.1"
                     /locus_tag="HT134_RS27145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27130"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_175603287.1"
                     /transl_table=11
                     /translation="MTAMAPARTETDLSFLLDHTSHVLRTRMAAALAEIGLTARMHCVL
                     VHALEEERTQIQLAELGDMDKTTMVVTVDALEKAGYAERRPSSTDRRARIIAVTEAGAA
                     VARRSQEIVDGVHREALRALPEDEREVMVRALNRLVSGHLAEPAEGPQPARRARERAK"
     misc_feature    complement(22198..22212)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.04"
                     /tool="antismash"
     gene            22223..23683
                     /locus_tag="HT134_RS27150"
                     /old_locus_tag="HT134_27135"
     CDS             22223..23683
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895400.1"
                     /locus_tag="HT134_RS27150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27135"
                     /product="MFS transporter"
                     /protein_id="WP_175603288.1"
                     /transl_table=11
                     /translation="MSYVRNSRWTALGVLSATGLMTILDGSIVTVAMPAIQHDLGFSPA
                     GLSWIVNAYLIPFGGLLLLAGRLGDLVGRRTMFLAGNAIFTAASLLAGAATGPGVLIAA
                     RFLQGVGSALASAVVLGILVTLFSEPAQRAKAIAIFSFTGAAGASIGQVLGGVLTDGLS
                     WPWIFLINVPIGAVTVALALLVLPADRGAGLAAGADVVGAALVTGGLMLGIYTVVRVEE
                     YGWLAAHTLGLGAVSLALLAAFVVRQATARTPLMPLRILRSRNVTGANLAQMLTLSGMF
                     AFQVLVALYMQRVLGYGALDTGLAMLPAAVGIGAISLFVSARLSARFGARAVLLSGLVL
                     LIAAMLLLTRVSVDAGYLTHLLPVMVLISGGGLVLPALATLGMSGARESDAGLASGLFN
                     TTQQVGMAIGVAVLSTMAASRTGELLAAGAGQAAALTGGYRLAFGISAGLLVAAFAVGL
                     LVLRRPAPDAARPAQEDGAAVAEPSLSS"
     gene            complement(23754..24152)
                     /locus_tag="HT134_RS27155"
                     /old_locus_tag="HT134_27140"
     CDS             complement(23754..24152)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00377.1"
                     /locus_tag="HT134_RS27155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27140"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_175603289.1"
                     /transl_table=11
                     /translation="MSRLTLACRHLPGATVMVVGGEIDSANAARVESFIAKSRRRPGDH
                     LVFDLTEVRFMDSAGLRTLLNAYLDAEEHGGSVRLAALQPMPARLVEITRVGEHLPVHA
                     TVQEALTAVLSSPEPPRRPATGTSSDVA"
     gene            complement(24321..24686)
                     /locus_tag="HT134_RS27160"
                     /old_locus_tag="HT134_27145"
     CDS             complement(24321..24686)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893237.1"
                     /locus_tag="HT134_RS27160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27145"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_175603290.1"
                     /transl_table=11
                     /translation="MTTPVHLTQISADPATGTCVLALAGELDYISAAQLRADMESTLRP
                     EHRHLVLDLSGLDFCDSTGIRLFLVFRKLILERGGSIALAGLTSRLERVFHMTGLSQAF
                     NLYPDAEQARAAITADA"
     gene            complement(24683..25996)
                     /locus_tag="HT134_RS27165"
                     /old_locus_tag="HT134_27150"
     CDS             complement(24683..25996)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF018884.5"
                     /locus_tag="HT134_RS27165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HT134_27150"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_175603291.1"
                     /transl_table=11
                     /translation="MTATLIDPGAEAARLEALRRYQVLDTPPEGAFDRVVALAARAFGA
                     PIASVTFVEDERVWIKAHTGLAGVPHDLAPDPGLCVSAILESEPYVVADTLTHPEACDH
                     PLVRDEPHVRFYAAAPIVTADGHRLGTVNVMDVEPREVDEAGLHTLTDLAALVATQLET
                     RLSARAALTLERRLRQQAEAERGRLELLTSTLRKVLLPPSPPKVPGLDIATHYHVASAD
                     QVGGDFFDVFRLDEHNWAFFLGDVCGKGADAAVVTALARHTLRAAAVYAGDPEAVLANL
                     NMVLMDEFLGADPCYCTVLYGVLTPTDEGTRVKVAGGGHPPALVVRAGGDVEALRTEGG
                     MLVGLLQEARFAVAETTLLPGDGMLLYTDGLTEARTPAGHMYGEDRLRSLAAGLAGQPA
                     QAVVTRLEETLSAFGPGLTDDTAILSMTVPPIVKRHSR"
     misc_feature    26066..26079
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.66"
                     /tool="antismash"
     misc_feature    26067..26080
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.71"
                     /tool="antismash"
ORIGIN
        1 ctcgtcgtcg gcgtacttgc cgcggtccgg cgtcacctgc acgggctcgg tctgcacgcc
       61 cgccgcgtcg acgccggagg ccagggcctc gtagacggcg tcggcgtaga tgcgcgccgt
      121 ggcgtcgtcg gccaggttgc cgtacgcggc gaccgcgccg taccacttgg cggggtcctt
      181 gcgggcggtg gcgtccagcc cgagcgcgtc ggccttggcg cgcagcacgg cggcgccgcc
      241 caggacgttg gacgcgtcgt cggtcttcag cttggcgacg ggcagggagg tgagcttggc
      301 cgcctcctcc agcgccttgg tcttggggtt gctgaccagg tgcatcacgc cgtagccgcc
      361 gctcgcgctc ggctcgccct cgtggttgtc gaggtgcgtc tcggcgtagc ccagggcgac
      421 cagcaggtcg cggggcacct cgtaggtgga ggcggccttg gtgaaggcgt cggccagggg
      481 ggtggccgcg gtggtggcgg cgggggtcgc ggtggcggcc tgggccaccg ccgggccgga
      541 cagagcaatg agtccggcga tcacaagagt tgtagtcttc atcatccgca atgctcagag
      601 ggactgttgt aggtggtgga gccggccgag ccgccccatc tgacgcactt gccggcggca
      661 gaggcggtca cggggcccgc gtagtacgcg aagttgccgg tgtcggtctg gcgcgccgcg
      721 cccgcgacct ccagataggc ggagaccgcg gtggccgtgc cgaccgaggt cgacttgatc
      781 gtggctacgc agttcttgcc ggtggagctg ttgtagagca ggtagaccgt gccgtcggac
      841 ccgaggggcg cggagtcgat caccttgtgg ccggagccgc agacggactc cgcggtgtgc
      901 gggttggtgg tgccgccgcc gcaggagttc cgggaggtga cggtctgcac cgggtagccg
      961 aaggtcacgc cgtcgaagac ggccttctgg atgttcgccg ggtaactggt gcccctgcgg
     1021 acctcgaagt gcaggtgcgg ggtgatgtcg ttgcccggct tgctggtgtt gcccaccgtg
     1081 ccgaccggct gaccctgcga cacgctctgg ccggcgctca ccgtgcggct gttcaggtgg
     1141 gcgtagtagg tggcgtagcc gtcaccgtgg tcgatcttga ccagattgcc gaagccgttg
     1201 gccgagccct ggtgcgcgga gatcacgacc gtgccggagg ccgcggcgac gacggtgtcg
     1261 ccgaggtccg cgtccggggt gccgccccgg ttgaagtcga tctcgtacga ctggtgggcg
     1321 ctgcttccgc tggagtcacc cgtccagctc tggccgcacg ggaacggcag ctggaaagtc
     1381 ggtgccgcga gggtcgtcgc cgtctccgcc gtggcggtgg aggtcggcgc gggcaccggc
     1441 gaagccgtgg gggagggcgc ggggtccgcg aaagcggccg tacctgtccc cagactgact
     1501 aagagcgcga aacccgtgat cagcgccccg ttgagcttca tcgggtgatc ctttctggtg
     1561 ggatctctga gacaagggtg tgcatatggc gcacaagaaa cgtccagacc cggtacaaag
     1621 agctgtcacg cctccataag gagcagatgc ggtcatgacg gtcacttttc acgtgcttgg
     1681 accgctggag atccggacat cgggtcaacc cgtccggatc tccggcaaga aacctcgcct
     1741 gctgctggcc acgttgttgc tggaagcggg cggggtcgtc ggtgccgacc agttggtcga
     1801 ggtgctctgg cccgagcgcc cgccccgatc cgcgcaggcg aacctgcgca cctatgtgag
     1861 ctcgctccgg acggatctgg gcgaggacgg ccgatgcctg cgcggcaacg gctcgggtta
     1921 cgccatcgac gtgccggagg gcgcgctcga cctcttggtc ttcgaggagc tggtgggcca
     1981 ggcccgctac gaggaggcgc tgtccctgtg gcgcggcgcc ccgctcgccg acctgccggg
     2041 cagccccctc tgggaccgcc gcctcgaccc cctccacgag gtgcggctgc gcgcggccga
     2101 ggagctgatc agccggagga tggaccaggg cgaccacgcc ggcgccgtga gcgagttgcg
     2161 cgggctgctc gccgagcacc cctaccgcga ggacctgtgg ggacgattac tcctggccct
     2221 gcaccggggc ggcaggaagg ccgaggcgct gcgcgcctac gccacggtcc ggcagctcct
     2281 cgtggacgag ctcggcgtcg agccgggcac cggactgcgc gccgcgtacg agtcgatcct
     2341 cgccgacgag gccccgcccg cggccccccg ccagctcccg cccgacgtgc cggacttcac
     2401 cggccgggcc gacgccctcg ccgcgctgaa cgagccgttc caggtcgccg tcatctccgg
     2461 gcggcccgga gtgggcaaga ccgcgctggc cgtgcacgcc gcgcacgcgc tgcgcgagaa
     2521 gttccccgcc ggccagctcc acctcgacct cgacggccgg gagccggccg acctcctcgc
     2581 cgaggcgctg cgggcgctcg gcgccgacac gcccccgccc acggtccacg agcgctccgc
     2641 gctcctccgc tcgatgctcg ccgagcgccc gatgctcgtc ctgctggacg acgcgctcga
     2701 cgcctcacag gtacggccgc tgctgccggg caacgactcc gtggtcatcg tcaccagccg
     2761 ccggcgcatc accgagctgc ccggctcccg ccacatcgac ctcggcgagc tgccggtcga
     2821 cgacgccctg cagctcctcg gccggatcgt cggccccgac cgggtggccc gcgagcagga
     2881 ggacgcccgc gccatcgtgg cggcgtgcgg cgggttgccg ctggccgtgc gcagcgccgg
     2941 ggcccggctc gccggccggc ccggctggtc gctggcggtc ctgcggcaac ggctggagga
     3001 cgaccggctc aacgagctgc aggaggtacg cgtctgcctc gaccgcagct accgggacct
     3061 gcccgacgag gccgcccgca tgctcggcac gttcggccgg ctcggcgccc tcgcacagcc
     3121 cggctgggtg gtcgacgcgg cgctcgaccg gcatcgcgct gacgatgtga ccgatctcct
     3181 cgtcgacgtg aacctgctgg agctcgtcgg caccgacccc gtcggccagc cgcgctaccg
     3241 cgtccccgac ctgatccgcc gccacgccct cgaacgcacg cccgaccgcg acgccctcgg
     3301 ccgcgtgctg gccgcctgga ccgcgaccac cgagcacgcc atggcgcggc tgcccaccac
     3361 cgtcttcagc ctcaccgcgc cccgcacgcc gcgctggcgc ctgcccgagc agacgctgga
     3421 gcggctcacg tccaacccgc tcggctggtt cgaggccgag cacgactcgc tcgtcgcggc
     3481 cgtcggcgtg gccgccgagg ccgggctcgc cgagtcggcc tggggcctgg ccgccgccat
     3541 ggtcccgtac ctggacctgc actgccggct cgacacctgg cagcgcaccc acagcgtcgc
     3601 cctgcaggcc gcccgcgccg gcggcgacac gtacggcgag gccgccatgc tgcgcgggct
     3661 cgcccaggtc gcgctctacc aggaccgcta cgaggaggcg gccgacgggt tcctgcgctc
     3721 ccgccggctc ttccacgacc tgggcgacgt acgcgccgag gccacgacga tctgcgggct
     3781 cggcgcggtc agccagttcc gcggccggcc ggcgcagtcg ctcggccact tcaagcgggc
     3841 cctggccatg ttcctggccg ccgacgaccc ccagggcgag gcgctcgccc ggcaggccat
     3901 cggccgggtc tgcctcaagt ccggcgacct gacccaggcg tccgagtcgc tggcccaggc
     3961 catgcggctg gcccaggagc tcggcgactc ccaccgcgag ggctgcgtct gcctccagat
     4021 gggacagctg cacgaggcgg tgtccttcca ccaccacgcg ctggacatct tcgagtcgct
     4081 cggcgaccgg cactgcggcg cgtacgccct gcagagcctg gcccggctcc aggtgcgcag
     4141 cggcgacctg gcccccgcct cgaccgggct ccagcgctcg ctcgaggtct tccaggagct
     4201 cggcgaccgt agcggcgaga tgtcgagcac gcagctcctc ggcgagctgt accgcacggc
     4261 tggccgcacg gggctggcgc tcgactacct caggcaggcc agcgacctgc gccgccgcct
     4321 gcccgtctga gacacacacc cacctcttgt ccccgcgtgt tcacaggggc gtcccgtcgg
     4381 gacgtgccgg atcgttccgg tcgtcccgac gccgggacgt tcgcctgcac gtaccgggac
     4441 gtccggtcgt atcgcttcgt ccgtacgcac tcccgtctcg ggacgtccgg acgtatcggc
     4501 tggtccggcc gggcccggcc cggtcgggcg tcaggcgggc gtcacaccgc cgtcaggagc
     4561 cggagacgat ccggcggacg agccgcctga ggcgggaccg ctgggggatg ccgcgcagcc
     4621 cgtcgagcgc ctcggccgcc gagggccgct tggccggcga gtggtcgagc atccgccgca
     4681 ccacgtcggg cacctcgggg ccgagggcgt cgggcccggg cggcagctcg ccggcgagga
     4741 gctggtaggc gatcaccccg gcggcgtaga cgtcggaggc ggccgtcatg cggtcgggcc
     4801 ggtcctggca ctcgggcgcc gcgtagtgac cgtcgaggac gttgctcagc tcgtgggcca
     4861 ccgtgaagtt gcgcgggccg ggcttggagt agtcgaagcc ggtcagcacg gcgtggccgt
     4921 cgtcggtgac gagcacgcac gcgggcgtga gcgcgcggtg gatgacgccg tgggcgtgcg
     4981 cgtgcgcgag accgctcagc aggtccggga tcacgaacgg cgacccggcg ccccggcccg
     5041 ggctcaggtg cagcgcctcg ccgtggacgt cgtccagcac gagcacgaac cggctctcgt
     5101 cgtcgatggc gaagaagtcg cgcgagcgca ccacgcacgg gtggggcggg atgcgggcca
     5161 gcgactggta ggcgttggcg atgcgctgcc gctcggcggc ccgggcggcc tcgtcggcca
     5221 gcgggtcggc ctggtagacg cgcagcagca cggtctcgct gcccggcagc gtcgcgttga
     5281 acgcgcggta ctcggtgacc ctggtgtcgc cgccgagctg ctcctcgacc tcccagttgc
     5341 cgtacctggg aggcgcggtg ctgcgccgta cggtctggtt cagcgcgtcg aggatcgccg
     5401 tcaggtacgg ccgggcgtcg gggctgcacc ctcgcttgac ccgcgacgcg tcggccagca
     5461 tcggcaccag gccggccagg tcggtcacgt gcgcggagtc gcgcccggtg ggatcgacca
     5521 gctcggcgtc gggcgaggtg agcacgacga tgctgtcgac gtagacgcgt tcgagctggg
     5581 tggcccggga caccagcagg cccttgagcg cccgcgcggt gccgcgcagc ttcgtcaccg
     5641 gggagccgaa cgcctcccgg cgcggcggga accagcgcga ccccgacacc tggatgcggc
     5701 cacgcgtgcc cttgacgtcg accaccacca gcgagtggcc ggtcaggacc agcaggtcca
     5761 cctcgaacac gtcgtcgcca cgcggcacct cgacgttgtg cagcagcaac cactcggccg
     5821 gggcgtggtc gcgcagatag gcgatcacgc gccgttcggc gtcgttgacc ggacgtcccc
     5881 cgccgacgat ctgtgccatg ggcatatcct cgcacgtgga cgcattgaca gcatgttgtc
     5941 gttatgacag cgtgttgtca tgatgaagac taaaaagccg gtacatgtgg ggatctatga
     6001 cacctgggcc gactgggagg ccgggcacgc catcgcccac ctccgggccg aacggttcca
     6061 ccgcgagccc ggcggctacg agatcgtcac cgtcggcctg tccaccgagc cgatcaccac
     6121 catgggcggc ctgcgcgtcg ttcccgacct cgcgctggag gacctctcgc ccgccgccag
     6181 caccatgctg atcctcccgg gcgccgacct gtgggacgcg ggcgacgcgc tcgcgccctt
     6241 cgcccgggcg gcccgcgcgt tcctcgacgc gggcgtgccc gtggccgcca tctgcggggc
     6301 cacggccggg ctggcccgcg aggggctgct cgacgaccgc gaccacacca gtgccgcgct
     6361 gccgtacctg gaggcgcagc ccggctacgg gggcgccaag cgctatctcg accgcgacgc
     6421 ggtgacggac ggcgacctca tcaccgccgg gcccacggag ccggtggcct tcgcccggga
     6481 gatcctcagc cgcctcgacg cgtaccggcc cgaggtgctg gacgcctggt acaggctgtt
     6541 cgccaagagc gacccgtcgg cgttcggcgt cctgatgtcg gcatgaccgg gacggagccc
     6601 ccctttacgg acgatgccgg ccacgaggcg acgcccggag gtgagacgcg agacggcgag
     6661 ccttccaggt ccactgcgtc ttcggggtct acggcgtctt cggggtctgg ggcgtcttcg
     6721 gggtctacgg cgtcttcggg gtctggggcg tcctccgggt ctacggcgtc ctccgggtct
     6781 acggcgtctt cgggggctgc cgcgtcgtcc gagtctgccg cgtcgtccgg cgggtccacc
     6841 ggggccggcg agtccgtggc gtcggtcgct tccgccggtg ccgccgccgc tcccggcccc
     6901 gccggtgccg ccggtgacgt cgggccggac gcggacgacg cggcggcgtt cctgtcggcc
     6961 gccgcgttga ccgccttccg gctcaacggc cagttcctgg aggtcgccga ggagctggcc
     7021 cggcccgccg ggctgacggc ggcctggtgg caggtgctcg gcgccgtcct ggccgagccg
     7081 ctgcccgtgg ccggcgtcgc ccgcgtcatg ggcatgaccc gccagggtgt gcagcggatc
     7141 gccgacctgc tggtggagcg ggggctggcc gagtaccggc ccaacccggc ccatcgccgc
     7201 gccaagctgc tccagccaac cgcggccggc cgcgacgcga tcgcgttgat caccccgggg
     7261 caccggcgct tcgccggacg cctggtcgcc cggctcggcg aggcggaggc ccgcgagtgc
     7321 ctgcgcgccc tgcgcctcct ctcctccgcc ctcgacgacc tgtccccctg agcgggactc
     7381 cccctgagcg ggactcctcc tgagcgaacg gcgcgctcaa agatttggat gatcgtgctt
     7441 aaacaacgac gtccgcgcgt cgcgccattc tgtatatggc ggtgattcgg caggcgccgc
     7501 ggaaagcgcc gatgtaccaa gaaaacgagg tggctccttg accgccatga ggctttcttg
     7561 ggttgcgacg cccgtccggt gccgggatcg ttattgacgg cacctcaccg ccccgtacaa
     7621 gcgactatgg cgccggtgat ttccgcgccg atcaatggag gaaacaaaca tgatccgtcg
     7681 tattctcgcc ggtgctgcca tcgcgggcat cgcgttcggt ttctccgcca ccgccgcctc
     7741 ggccgacgac accccgtaca acagcggcaa cagcgtgctg agccagttca gcgcgctcca
     7801 caacgccacc gtgctcaacg gcgtgctcaa cgactcggtc aaggacatcg acgtcctcaa
     7861 cgtcggcaag ctcgaagagg ccaacgtcat ggtgctcaac aacggctgac ccgctgtcga
     7921 gggcgcgggc cggcggccgc catccccgcg tggtccggcg cctcgtcaac tgcacagaac
     7981 ggccgcgact ccccgtgcgg gagcgcgctc cgtccggctc gccgagcccg acgcgacggc
     8041 ggcccgggac gttccgctcc agagcgagac gtcccgggcc gccgtcgtcg tttctccggg
     8101 cccggaggcc gtccgcgtcc gcccgtcgtg gccactgccg gtatcggaca ttcgccgccg
     8161 cctcgcaata ttgtgctgaa tgcttcattt gtggacatat ccgggcgacg cataatcaag
     8221 cgccaagcaa ttgagggttg tatttgactt gggcttagcg aattcgagtt gcggggagcc
     8281 ggtgtcgcgc gggatcgtta ttcggcctct cgcggtccgt gagagcgcga ttcagaagaa
     8341 gcgcctcccc ttccgcgctg attcccacga aggagaaatc aaaatgatgc gtcgcattct
     8401 cgtcggtgca gccctcgccg gtgccgtctt cggactctcg accgtgagcg cccacgcgga
     8461 cagcggcacc agcgcgctct gcacccccaa gccggtcgtg accgactgcg cccccaagcc
     8521 tgtcgtcctc actcccaagc cggtcatcgc ggttccctgc gccaccaaga tcgtgacgac
     8581 cgcgacgcag tgcacgacca cctgcacgac gaagtgcgtg accaactccg gggccacgca
     8641 gtcctcctcg acgcagtcca cccagtcgtc gcagtcgtcg cagtcctcgt ccacgcactc
     8701 cacggccacc agctccaccg ccacgagctc gatcagctac gtgccgatga gcggcccgct
     8761 caacaccggc aaccagatcg gcagccagtg gtccgcggcc aacgacctcg ttctgctgaa
     8821 cgacgtggcc aacaactccg tcaagcacat cgacgtgctc aacgtcggca agctcgacaa
     8881 ggtcaacgtg ggcgtgctga acaaccacca ggcggcggcc acctccgtgc tcgccccctg
     8941 ctgagccacg ggtaggcacg gaccggcctc cggcctgctt ccggaggccc gcgttcaggc
     9001 cgcgctcgtc tgatcggggg cccgcgtcct cagacggcct gggtccggcc ggcgcccgtg
     9061 tccgagccct cccgagcggc tcgtacacga cgacgcccga cagggagagc accagctgga
     9121 tggcggcggt gctcacccgg atcgggccgg tggcgccggt gggatggtgc actcccaggt
     9181 ggacccgggc ccgcgtgtgc gcggtgacga gcgagaagtg atccgccggc gggtgtgggc
     9241 gggtgatggc gatcctgtac aggggagccc atgccccgtc cggcggagac cgacgcgagg
     9301 gtcaaggggg ccgcccgggc catcaggtcc gcggcggccc gacgcgtacg gcccatggcg
     9361 aggtgagggg ttgggccggg ttgggtacgt accggacaga gcctcctcag accggctcat
     9421 acccccacag ccataccagc cctttagggt caatatcact tagcgaacga caattcgtgt
     9481 agcctggttc cggactggcg agacacgcgg cgccggtccg ttcccccagt gcgcaggggc
     9541 cggaggacga cccccacgct cggagagatg ggggtgcgcg gccgatgagc ggcgacacgg
     9601 acacgaacga gcggctgctc tacgccgacc ggctcgtccg gatctccctg cggatgcctc
     9661 tccgggaccc gcggaccaca ccccacctgc tgttcgcgac ggccggcacc ggccccgtgg
     9721 tcacactcgt cggcgagatc gacgtgagca actgcgaggc gctgacgcgg gcgctgaccg
     9781 cctgccgagc cggtggcggg cacgtgaccg tcgacaccgg ccggctgagc ttcatcgacc
     9841 tggcgggcct gcgggcgctg atcatgccgg cgctccccgc gccgcagcgc tgggtgcgcc
     9901 tgcgcaacgt cacgccgtac caggagaggc tgctgcagct gatcggctgg ctctacgagc
     9961 tggaccccga gcccgacagc gccgcgccgc aggccactcc ctagaccgcc gagccccaca
    10021 tcatcgcggc cgaggtgccg agacccgtcg gaccggccag ccgccaccgg ggcggctggt
    10081 ggtggcggcg cagcgactcc tcgtcgtagc ggcggcagtc gcgatgccac accaggatgc
    10141 ccgacatcca gttctccagg tcccgcacgt agccgcgcag cacctcgcgc gcctcctcgc
    10201 tcagcccggc gtcgtcgtag agcaccggca gctcgtgctc ggcgacgtgc tggaactgcc
    10261 gcatccgcga gttgatcagg tcggtcgcga tgccgagcgc ctcggggtag cggcagccga
    10321 agaacgtctc ggtgaccagc acgacgttgt gcgtctcacc ctcgaactcg acctccttct
    10381 ggtacgagaa cacgtcgttg agcagggccg cgtagtccat ggcggagttc tccagcgacc
    10441 gcagcggccc gctgtcgtag atctccggcg gcacccggtc gccgtgggcc aggcggcaca
    10501 ggctcatcgt gagctccgag ccgaacgtca tgcgccgcat ctcgacgtag tcgacggggt
    10561 cgggcacccg gttggcgatc tggttggcca gctcccacag ccagctctgc accatgtcct
    10621 cgatcgcccc gcggaacctg cggcgcgccg ccggctccat cggcccggcc gtgcgggccc
    10681 acaggtcggc cagaccgcgt tcgagcgcgt tcaccggcac cgcgagcggc ggcccgtcga
    10741 ggggcatgaa catcggcagc cgctcgacgc acaccttggc ggcggccagg ttgcgggtgc
    10801 ggccgaacac cacggggaag tagtcgtcgc cgtaggtgcc ccaggccagc caggccgacg
    10861 acaggtcgag ctgggcgggg gaggcgtcgg ggtggatgcc cgccgcgcac agcggcaggt
    10921 cgtagtcggc cagcttgtcg gcgtcccaga cggccgagcc caccacgccg ggctgcgcct
    10981 ccaggatgcc catctcccgc gcccaggtga tgacgttgac acgggccgcg ccgaggtggg
    11041 gcgacagccg gggctcgaac ggcatgagca gctcggggat gaccgacggc ccgacccgcc
    11101 ggtgggggac gtgcgcgtac gagcggaacc gcttggcgcc gaggatgtcg acgaccgcgc
    11161 gcatgccgag ccccgcgccg cgcccggcgc gctcgttcat gtagcggctg gagcgcatgt
    11221 gccactcatg gccgccggac tgccagtcct gcagcccctt gacgtaggcg agcacgccgg
    11281 cgcaggacag cgggtcgagg ccgtgctcgg cgaacagcgg gcccagctcg gtggccaccg
    11341 tgtgctcgaa ctgctggagc cgggaggtga gcaggtcgtt gacggagtcg gcggcctcct
    11401 gcgtggtgca gccgaggaac gtctccagca ccagcacccc gttgctcagc tcgccctcct
    11461 cctccacctc ccgctggtag gagaacaggt cgttgcgcag gtggacggcg tcggagaagg
    11521 tgtcgcgcag cacccgcatg ggccgggagg cggcgatgcg ggcgggcacc tcggccccca
    11581 cggcgtgctc gacgagaccg gccgaccacg gcgccccgcc caccttgcgg cgcatctcga
    11641 tgtactcgac cgggttgggc acccggccga tgttgatgtt ggacagctcc cacagcgact
    11701 cgttcagcag gttgcgggtg ctctcggcga agcgctcccg ccactgctgc gagcggctgg
    11761 gcaccgtgcg ccgccacagg tcggccaggc cggcctccac cgggttggcc ggctccggca
    11821 tgccggccgc caggtccggc ggcatgaacg cgggcagccg gtcgaggtgc tgcttgccgg
    11881 cctcccggtc gccggtgcgc ttgaacagct ccaggaagtg gtcgtcgaag aagaacaccc
    11941 acacgtacca gtcggtgatc aggctcagct cgggcccgtc gcagtcggga tgggtgtagg
    12001 cgcacagcag ggcgtagtcg tgggagtcga ggtcacgctg ctcccagacg ccggagccct
    12061 ccagcatgcc catggcgcgg gcccactcgc gggagtgccg ccgggcctcc tccaggtggg
    12121 ggttgagccg ggcgggatac ggcaggtaga agtcgggcag ctcgaacggc tggtcggcca
    12181 tgggatcact ccgttgcgct cgtgaacctc tgatcgtgaa cctggacgtc ggtgagcatg
    12241 ccgagcgcgt cgggcaccag gacggccgcc gaatagtggg cgctgaccag gtaggaggtg
    12301 atggcccgct cgtcgatgcc ggtgcgccgc acgctcaggc cgggcaggcg ctcgccgggc
    12361 aggccggtct gccgcagccc caccacgccc tggtcgtcct cgccggtgcg gaacgcgagg
    12421 atcgcggtcg tgcccgcccg gctgaccggc agcttgtcgc agggcaggat gggcaccccg
    12481 cgccaggccg gcagcgcgcg cccctcgacg gtgacgggct cggggtggac gccccggcgg
    12541 ttgcactcgc ggccgaacgc ggcgatcgcc gccgggtggg cgaggaagta gcgggtcttc
    12601 ttgcgccggc tgagcagctc gtcgaggtcg tcgggggtgg gcgggccgcc gcgcgtgggg
    12661 aggcgctgcc ggggatcgac gttgtgcagc agcccgaagc cggggtcgtt gaccagcgcg
    12721 tgctcctgcg cctccaggac cgcctcgacg gtgagcctga gctgctgctc ggtctggtcc
    12781 atcggctcgc tgaacaggtc ggcgacccgg gtgtggaccc ggagcacggc ctgggagacg
    12841 ctcagctcgt actcgcgcgg gccggggtcg tagtcggcga acgtgccggg cagcaccggc
    12901 tcgccccggt gcccggcggc cacggcgatg gccgcctcgc cgtgcttgtt gcgcggcctg
    12961 gccagctcgg cgcggtgccg gtcgagccgg gcgcgcaacg acggcgaccg gtcggccagc
    13021 gcgtcgaacg cctcccacgg caggtacagc accgtgcagg gcgtgcgcgc ctccagcgtg
    13081 tacggccagc gcccctcggc cccggacggt ccggccccgg accgctcggc ggccccgagg
    13141 cttgcggccc aggaccgctc cgccccggcg tggtcccccg ccgacagcgt cgcccggacc
    13201 agggcgtcgc cgtacgggcc gcgctccagc cggaccgcct tgccgtgcgc gagcagcacc
    13261 aggccgtcgg cgggctcgcc ggcccgcacg acggcctcgc ccggcgcgta ctcccgctgc
    13321 tcgaacaggc cggccagccg ctccaggacg gcggcgtcgt cgtacccgcc cagcggcggc
    13381 agctcggcca ggctgggcgg gatcacccgg acccgcgccc cctcgaaggc gaagcccacc
    13441 cggccgccgc ccacgggata ggtgtgccgg cggttgaccc ggtagacggc gccggccacc
    13501 tccacccagg gcaggacccg cgtcagccag cgaggcgtga tctcgcgcgc ctgcggcggg
    13561 gtcttggtcg tcgtggcgag cagccgcgcg gcctcggtgc cgaggctctg cggtacggcc
    13621 tcggtgccga ggctctgccg cgcggcgtcc cgctgctgct ccgtcaaacc ggcaccctcc
    13681 atcctgctag tgctcgtgtc cgagctcgac gtcctccagg acggccagcg cgtcggggac
    13741 caggacggcg gcggagtagt aggcggtgac caggtaggag atgaccgcct tctcgttgat
    13801 gttcatgaag cggaccgaca ggcccggctg gtactcgtcg gggatgccgg tctggtgcag
    13861 gccgacgacc ccctggctct cctggccggt gcgcatgagc atgatcgagg tggtgcgggt
    13921 gtcggtgacg gggatcttgt tgcacgggaa gatcggcacg ccgcgccagg ccggcacccg
    13981 gtgcccgccg acctcgctcg cctgcgggta gaggccgcgc ttggagcact ccctgccgat
    14041 ggcggcgatg gcctgcggat gggcgaggaa gaaggccggc tccttccaca ccttggcgag
    14101 cagctcgtcg aggtcgtcgg gggtgggcgg gccgctgcgg gtgcggatgc gctgggagaa
    14161 gtcggcgttg tgcagcaggc cgaagtcgcg gttgttgacc agctcgtgct cctggcgctc
    14221 gcgaagcgct tcgatggtga gcctgagctg ctggtcgagc tggctcatcg gctggttgta
    14281 caggtcggag acgcgggtgt ggacgcgcag gatggtctgg gcgacgctca gctcgtactc
    14341 gcgcggcgcg aggtcgtagt cgacgaacgt gccgggcagc gtcggctcgc cggtgtggcc
    14401 cgacgacatg tcgatcgcgg cctcgccgta gtcgttacgg gcgcggttct cgacgtcgcg
    14461 gatgccggcc aggtggtcgc gcagctcggg ggactggtcg tggatctgct ggaagtcgtg
    14521 ctgggagagc acgaggacgg tgcagctggt ggcggccttg gcggtgaagg agaagcggcc
    14581 cggctcggtc aggagctgct cgccgaggtg gtcgccgtcg gccagcacgc ccagggcctg
    14641 ctcgtcgccg taggcgccgt ggccgctctt ggcgacccgg ccgtgggcga tcagcacgag
    14701 ctggtcgacg gggctgccct cggtgacgat cgcctggccc gcttcgtact cgcgctggat
    14761 gaaccgggcg gccagcgcct ccagcacctc catctcgcag aagccgcgca gcggggccag
    14821 ctcggtgagc tccgcgggga tgacccgcac ctcggcgccc gtggtggtga aggtgatgcg
    14881 gccgtcgccg agggtgtagg tgagccggcg gttcacccgg aagacgcctc cggaggtctg
    14941 cacccagggc agcagcttca gcagccagcg ggaggtgatc tcctgcatct gggggaccgt
    15001 cttggtggtc gtcgccagat tgcgcgcggc ctcggtgctg agactgagct gctggttgtg
    15061 tccttcggga gccgactcga acgtttcggt catactgcac caccaatctt catggggaac
    15121 gacgccggtg gcccggcgcg gggggatgga acgttccaga acccggggcg ggcggccgtg
    15181 ccggccgccg gtcgcctacc ggtcgcggtg ggcgagccgc tcggccagca cggccagcgc
    15241 ctcgcgcgcc tcggcggtca tgggggcggc ccgcagctcg gcggtcgcct cacgcacccg
    15301 ctcggcgatc atgtcctcca cctcggcgag cgcgccggtg gcgacgatga tctggcgcag
    15361 ctcgtcggcc tgctcctcgg tcaggtcggg gtggccgtgc caggtgcgca ggtaggagcg
    15421 ctgcgcgggc gtggcccgct ggaccgcgtg ggcgaacagc acggtgtgct tgccgtcgcg
    15481 caggtcgtcg agcgccgact tgcccgtctc ggcggacgag ccgaacgtgc cgagcacgtc
    15541 gtcgcggagc tggaacgcct cgcccagcgg caggccgaag cgggagtagg actccagcag
    15601 ctccggcggc gcgccggcca gggcgccgcc gatctgcatc gggcgctcca cggtgtactt
    15661 ggccgtcttg tagcggatca cggtgagcga ctcgggcacg gaggcgccgg cgcggagctg
    15721 ggccaggatg tcgaggtact ggccgctgat gacctcgctg cgcatggcgt cgaacaggtg
    15781 gtgggccacg cgcagccggc cgggctccac cccgcaggac gacagcagcg cgtcggccca
    15841 ggccaggctg agggtgccga gcaggatgcc gccggcctgg ccgaaggtct cggcgccggg
    15901 ccccgcgtgc agctgggaca ggcgccggtg gacggtcgcg tggccccggc gcagctcgct
    15961 gccgtccatg atgtcgtcgt ggatcagcag gccggcgtgg cacagctcca gcgccgccgc
    16021 cgcgctgatg atctcgtcgc agtcgccgcc gcccgccccg cgccagcccc agtagcacag
    16081 ctgcgggcgc acccgcttgc cgccgctgag gatgaagtcg gtcagcagct cgtacgccgc
    16141 gaccacgtcg gggtcggaca ccggcgcccg ccacgcttcg aggaagccgg tcaagcgctg
    16201 gtcaacgcga tctccgacca ggttatgagt gaagccgact gtcatgactg aaggcccctt
    16261 ccgccaaggc cacactacat gtagttattc atcgaacacg gagtgtgtaa agtctcttct
    16321 gtggctccag gtggcctgag cgcgggccgc gcgccggccg aagggctctg agctgggagg
    16381 acccggcgac acgctggcgc gcataactac ggagcgcatc cgaaaggtgt ctacttgtaa
    16441 ttacacgcag tgcgtttcca aacaagtggg gattccatgt ccatgcgccg ctcacatctg
    16501 agcctgctca tcgccgccgt ggccgccgcc gcaaccgccg gttgcggcgg cggcgtcacc
    16561 gattcctccg cctccagcgg ggcggcgtcg tccgcgtccg ctcccgccgc gcaggcctcc
    16621 ggtcaggacc gggcctggat gcggcagatc cacctgggcg gcctggccga gctgcacgcc
    16681 gccaagctgg ctcaggacaa ggggtcgcag gacgtcaagg cgctcggcga cacgctcgtc
    16741 agggaccgcg gcaccctgga cgcgcagctc gtgcgcgcgg ccgagcggca cggcgtccgc
    16801 ctgcccaccg gcctgtcgac cgcccagcag aaggaggccg tcgccctgga gaaggccggg
    16861 cacgcccggt tcgaccggcg cttcgtcaag gagatggccc agtcgcacag gcgggccatc
    16921 agctcgacca agcgggagat caagaagggc tccgcccctg agatcgtctc gctggccaag
    16981 tccaccctgc cgtccctgga gcaccacctg gccatgctgc gcgaggcgga cagctcctga
    17041 tcccgtacgg cggcttccgg ccggggcacg ggccgcgccc ggccggagcc gtttggcggc
    17101 gggtgtgggg gtatgggggt gccggcggga ggagcagcca tgaaggccgt cacgtggcac
    17161 gggaagcggg acgtgcgggt cgaggaggtc cctgatccgg cgatcaagga gccgaccgac
    17221 gcgatcatca agatcaccag caccgcgatc tgcggatccg atctgcacct gtacgaggtc
    17281 ctcgggccgt tcatgaccca gggcgacatc ctgggtcacg agccgatggg cgtcgtggag
    17341 gaggtcggcg ccgacgtcga gcacatcagg ccgggtgacc gggtggtcgt gccgttcaac
    17401 atcgcgtgcg gccactgcca catgtgcggc atgaggctgt acgcccagtg cgagaccacc
    17461 caggtgcgcg agcacggcat gggcgccgcc ctgttcggct acacgaagct gtacggccag
    17521 gtccccggcg ggcaggcgga gtacctccgg gtgccgcagg cccacttcgg gccgatcaag
    17581 gtgccggagg gcccggccga cgagcgcttc gtctacctgt cggacgtcct gccgacgtcc
    17641 tggcaggccg tggagtacgc ggaggtgcca gagggcggca gcgtcacggt tttcgggctc
    17701 ggcccgatcg gccagatgac cgcccgcatc gcccgtcacc ggggctaccg ggtgatcgcg
    17761 gtggacggcg tgccggagcg gctggagatg gcgcgccgcc acgggatcga ggtggtcgac
    17821 gcgcgcgcgg cggacgacgt gcccgacgcg gtgcggggga tgaccggcgg gcgcggcacc
    17881 gactccgtca tcgacgccgt cggcatggag gcgcacggct cgcccggcgc caagctcgcc
    17941 cagacgctca ccggatacct gccggacgcg gtggccgcgc cgctcatgaa gcaggcgggc
    18001 atcgaccggc tggtcgtgct caaccaggcc atcgacaccg tgcggcgctg cggcgtcatc
    18061 tccgtcatcg gcgtctacgg cggcatgacg gacccgctgc ccatgctgcg catgttcgac
    18121 aagggcgtca cgctgcgcat ggggcaggcg cacgtccggc gctggatcga cgacctcatg
    18181 ccgctggtca ccgacgacgc cgacccgctg gccgtgatgg acctcgccac ccaccggctg
    18241 ccgctggacg aggcgccgcg cgggtacgag atcttccaga agaagcagga cggcgccatc
    18301 aaggtgctgt tgcggcccta gggtttcggt cctttctccg ggggcagccc ggccggtatg
    18361 aaggtggtgg tggtcggggc gaccggcaac gtcggcacga gcgtggtgga ggccctgcgg
    18421 acggacgacc aggtgaggtc ggtcgtgggc gtggcccgcc ggttgcccgg gtggcagccg
    18481 gagaaggtcg agtggcgcag gggcgacgtg gtgaccgacg atctgacgcc ggtcttcgag
    18541 ggcgccgacg cggtggtcca tctggagtgg ctgttccagc cgaccaggga caccaccgtg
    18601 acgtggcggg ccaatgtgct gggcgccatg cgggtcttcc gcgcggtggc cgaggcgggg
    18661 gtgcccgccc tggtgtatgc ctcctcggtg ggcgcgtact cgccgggccc caaggaccgg
    18721 gcggtggacg agagctggcc cacgcacggc tggccgggcg ccgcgtacgg cagggagaag
    18781 gcgtacgtcg agcgggtcct ggacgtcttc gagaacgacc accccgacat ccgcgtggtg
    18841 cggatgcggc cggggttcat cttcaagcgg gagtccgcca cggagcagcg ccgcctgttc
    18901 ggcgggccgt tcgtgccgcg ccggctggtg cggcccgggc tgatcccgtt cgtgccggac
    18961 atgccggggc tgcgcttcca gtgcctgcac gccgaggacg cggccgaggc gtaccggctg
    19021 gcggtggtcc gtcaggtgag cggggcgttc aacctggccg ccgagccgcc gctggacgcg
    19081 gcggcgctgg cccggctgct gggcgcccgc acggtgcccg tcccgccgtt cctggccagg
    19141 accgcgatgg cggcggggtg gcacctgcgg ctgctgccgg cggcgccggg gctgctggag
    19201 atgctgctcc aggtcccgct catggacgtg acgcgggccc gggaggtgct cgggtggacg
    19261 cccgcgcact cctcgcagga ggcgatggag gcggtcgtcg aggggctgca cgagggcgcc
    19321 ggggcggaca ccgccccgct cgcgcccgac gagggcctgg ccgggcggct caaggagacc
    19381 accacggggg tcggcggccg gccctgagcc acgggtcacc cgatgatctg gtagggccgc
    19441 atcatctcgt tgtcctcgtg ttcgaggatg tggcagtgcc ggacgtaccg gccgggcagg
    19501 tcgaacgtcg ccttcacccg cgtgatctcg ccgggaggcg cgatgacggt gtccttgaag
    19561 ccgcgctccc atggctccgg gggccgcggg gccgccgtcg aacggtggat gggatgggcg
    19621 tccgccgtga aggtgtacag ctcccagacc tcggtggggt ccagggccgg attctcggtg
    19681 accgggtcgc cccacaacag ggggttcggg acgccgttct tcacggtgcc gagctggacg
    19741 acgacgggac ttacgtccgg gaagtcggcc gagccctgct cggtgagcga gagccgccgg
    19801 tggcgggtcg ccgggccgag cgggtggagc tgcggcaggg tcagctctcg tccggcgtcc
    19861 aggccgcgac cagggcgagg aggccgggga agcgggcttc gaggtcggcg acgcgtacgt
    19921 ggctgcgccg ctccaggccg tactgccgct gccgggtgac gcccgcctcg cgcagcgcct
    19981 tgaagtggtg ggtcagggag gacttggggc ggtcgaggcc gaaccagccg caggtgtggt
    20041 cgaacgcctc cgactccagc agcagcttgc gcacgatggt caggcgcagc gggtcgctca
    20101 gcgcgccgag gacggtctcc agccgcaggt cctcgaccgc cggctcgggc agcggctcgg
    20161 gcagtccggc gggctccggc agcgtcctga tggcgggccc cggacgcgtc gtggaaggca
    20221 tgtgcggctc ctcgttccgg ttgtcggttg tacgagtccg atcgtactgc atgctaagtt
    20281 cgattctgtt cgtactgtgt cggccggaag gagccgccat gtccatgagt cgagcgatgc
    20341 ccgtgagagc gccggcggag cgcccgggga cggccgccgc ggcggttccc acccgctggg
    20401 tctggctggc ggcctggccg gtcaccgcgg tcttcgtgct gtccaacgcg gccactccgc
    20461 tgtacgtgct gtggcagcgc gacatcgggt tctccaaggg caccctgacc gtggtcttcg
    20521 cctcctacat cgtcgggctg atcggctcgc tgctcgtctc gggagtgctg tccgaccggc
    20581 tcgggcgcaa gcccgtgctc ctgcccgcgc tcgggctcgc cctcgcggcc tgcctggtct
    20641 tcgcgacggc gggcagcgtg gccgcgctga tcgtggcccg gctgttcacc ggcgtcgcgg
    20701 tcggagcggt ggtctccggc ggcatggccg ccgtgtcgga cgtggccggt cccgcccgct
    20761 cacggctcgg ggccctgctg gcgtcctgcg ccatggtctt cggcgcgggg ctgggcccgc
    20821 tcctgtcggg agtgctgtcc gaggctctgc cggcgcccac cgtgaccgtc ttcgccgtgg
    20881 aggcggcgct gctggcgacc gccgtcgcgg tcgtgctccg tatgccggtc cgccgtccgg
    20941 ccgtgccggc ccagggcgcc aaggggcgcg cgcgggcggc gggctcctgg gtgcgggtgc
    21001 ccgccgtgcc gcgcggcaac ggccgtcacc tggccctggg ggtcgccgtg ttcgcgccgg
    21061 gcatcacggc gacctcgttc gtgctgtcgc tcggcccctc gctgctcgcc gggctgctgg
    21121 acggcaccaa ccggatcgtc ccgggggtca tggcgttcgc gatgttcctg gcctcgacgg
    21181 gagtgcagtt cgcggtccag aggctgcgcc gcggcgcgat cctgatcgcc ggggcggcct
    21241 ccaccgccct cgccatggtc gcgctcgtca ttgccgtgcg ggtcgcgtcg gtcgaggccc
    21301 tcgccgtcgc ggcgctgctg gccggcgccg gtcagggcat ggggcagctc ggggggctgt
    21361 ccctgctcaa ctccaccgtc ccggcggggc ggctggccga ggcgaacgcg gcgctcaacg
    21421 tcggcgggta cgtcctggcc ggcctgctgc cggtgtcggc cggttacctc agcgacgcca
    21481 tcggcctgac cggcggcgcg accctcttcg gcgccgtgct gatggggctc gccgtcaccg
    21541 gcggcctggt ggtggtgctg ggccgccggt gggtgccgga gcccaggtga cctgtcggaa
    21601 tcatcctttt gcagataatc cacagctgga cgacttgggt aggctgggag catgaccgcg
    21661 atggcgcccg cgcgcaccga gaccgacctg tccttcctgc tcgaccacac cagccacgtg
    21721 ctgcgcaccc ggatggcggc ggccctggcc gagatcgggc tgacggcgcg catgcactgc
    21781 gtgctggtcc acgcgctgga ggaggagcgc acccagatcc agctcgccga gctgggcgac
    21841 atggacaaga ccacgatggt ggtgaccgtg gacgcgctgg agaaggccgg gtatgccgag
    21901 cgccgcccgt ccagcaccga ccggcgggcg cggatcatcg cggtgacgga ggcgggcgcg
    21961 gccgtggccc ggcgcagcca ggagatcgtg gacggcgtgc accgggaggc gctgcgcgcg
    22021 ctgcccgagg acgagcgcga ggtcatggtg cgcgccctga accgcctggt gagcgggcat
    22081 ctcgccgagc ccgcggaggg gccgcagccg gcccgccggg cgcgggagcg ggcgaagtag
    22141 gcgagaagta ggtccgaaga ggatcgtcta ttacggaact atctgctacg gtctctcttg
    22201 tcgaactgag acaggagaga ccatgtcgta cgtgcgcaat tcgcgctgga ccgcgctggg
    22261 cgtgttgtcc gccaccggac tgatgaccat cctcgacggc agcatcgtga cggtggcgat
    22321 gccggccatc cagcacgacc tcggcttctc gcccgccggg ctgagctgga tcgtcaacgc
    22381 ctacctgatc cccttcggcg gcctgctcct cctggcgggc aggctgggtg acctggtcgg
    22441 gcgccggacg atgttcctgg ccggcaacgc gatcttcacg gccgcatccc tgctggcggg
    22501 cgcggccacc ggccccggcg tgctgatcgc cgcccggttc ctgcagggcg tcgggagcgc
    22561 gctggcctcg gccgtggtcc tgggcatcct ggtgacgctg ttcagcgagc ccgcgcagcg
    22621 ggccaaggcg atcgcgatct tcagcttcac cggggcggcc ggcgcctcga tcggccaggt
    22681 cctgggcggc gtgctcaccg acggcctgag ctggccgtgg atcttcctca tcaacgtgcc
    22741 gatcggggcg gtcaccgtcg cgctggcgct gctggtgctg cccgccgacc gtggggccgg
    22801 tctcgcggcg ggcgccgacg tcgtcggcgc cgcgctggtg accggcggcc tgatgctggg
    22861 catctacacg gtcgtcaggg tcgaggagta cggctggctc gccgcccaca cgctgggcct
    22921 cggcgcggtg tcgctggccc tgctcgccgc cttcgtcgtc cggcaggcca cggccaggac
    22981 cccgctcatg ccgctgcgga tcctgcgctc gcgcaacgtg accggcgcca acctcgccca
    23041 gatgctgacc ctgtcgggga tgttcgcctt ccaggtgctg gtcgccctct acatgcagcg
    23101 ggtcctcggc tacggggcgc tggacaccgg cctcgccatg ctcccggccg cggtcggcat
    23161 cggcgcgatc tccctgttcg tctcggcccg cctcagcgcc cgcttcggcg cccgcgccgt
    23221 cctgctgtcc ggtctggtgc tgctgatcgc cgcgatgctc ctgctcaccc gggtctcggt
    23281 ggacgcgggc tacctcaccc acctgctccc ggtgatggtg ctgatctcgg gcggcgggct
    23341 ggtgctgccg gcgctggcca cgctgggcat gtccggcgcg cgggagagcg acgccgggct
    23401 ggcctccggg ctgttcaaca ccacccagca ggtcggcatg gccatcggcg tggcggtgct
    23461 gtccacgatg gccgcctcgc gcacgggcga gctgctggcc gccggggcgg gccaggcggc
    23521 cgcgctgacc ggcgggtacc ggctggcctt cggcatctcg gccgggttgc tggtcgcggc
    23581 gttcgccgtg gggctcctgg tcctgcgccg gcccgccccg gacgcggccc ggcccgctca
    23641 ggaggacggc gcggcggtgg cggagccctc cctgagctcc tgatcagggc gcgaggcgag
    23701 ggcgcgaggt gatcgcccgg gccctcccgg cccgggccgg cccgtccgga gggtcaggcg
    23761 acgtcgctgc tcgtgccggt ggccgggcgc cgcgggggct cgggggagct gaggacggcg
    23821 gtgagcgcct cctggaccgt ggcgtggacg ggcaggtgct cgccgacacg ggtgatctcg
    23881 accaggcggg ccggcatcgg ctgcagcgcc gccagccgca cgctcccgcc gtgctcctcc
    23941 gcgtcgaggt aggcgttgag cagcgtgcgc agccccgcgc tgtccatgaa ccgcacctcg
    24001 gtcaggtcga acacgagatg atcgccgggc cggcggcgcg acttggcgat gaacgactcc
    24061 acccgggcgg cgttggccga gtcgatctcg ccgcccacga ccatcacggt ggctcccggc
    24121 aggtgccggc aggccaaggt cagccgggac atcagggcac cagccggccg ctgggtcgaa
    24181 cggcgcacgt cgccatgagc cgacgatatc ccgccgggcc cccgccgacc gggccggaga
    24241 tcccggcatt cgcatcacga atatcgcggc gcgtctgccg gccctcgcga attggctgtg
    24301 ccgtgcctcc gggaccggcg tcaggcgtcg gccgtgatgg cggcccgggc ctgctcggcg
    24361 tcgggataga ggttgaacgc ctgggacagc ccggtcatgt ggaagacgcg ttccagccgg
    24421 ctggtcagcc cggccagcgc gatcgacccc ccgcgttcca ggatgagctt gcggaagacc
    24481 aggaagaggc ggatgccggt ggagtcgcag aagtccagcc cgctgaggtc gagcaccagg
    24541 tgacggtgct cgggccggag ggtgctctcc atgtcggccc ggagctgggc cgcgctgatg
    24601 tagtcgagct caccggccag ggccaggacg catgtgcccg tggccgggtc ggcggagatc
    24661 tgcgtcaggt gaacgggtgt ggtcaccgcg agtgcctttt cacgatcgga ggaacggtca
    24721 tggacaggat ggccgtgtcg tcggtcaatc cgggcccgaa cgcggacaga gtctcctcca
    24781 gccgcgtcac caccgcctgg gcgggttgtc cggccaggcc ggcggccagg cttcgcaggc
    24841 ggtcctcacc gtacatgtgg ccggccggtg tgcgggcttc ggtgaggccg tcggtgtaga
    24901 gcagcatgcc gtcgccgggg agcagcgtgg tctcggcgac ggcgaagcgc gcctcctgca
    24961 gcagcccgac gagcatgccg ccctcggtgc gcagcgcctc gacgtcgccc ccggcgcgga
    25021 cgaccagcgc cggagggtgt ccgcccccgg cgaccttgac gcgcgtgccc tcgtcggtcg
    25081 gcgtgagcac gccgtacagg accgtgcagt agcacgggtc ggcgcccagg aactcgtcca
    25141 tgagcaccat gttgaggttg gccagcacgg cctcggggtc gccggcgtag acggcggcgg
    25201 cgcgcagggt gtgccgggcc agggcggtca cgacggccgc gtcggcgccc ttgccgcaca
    25261 cgtcgccgag gaagaacgcc cagttgtgct cgtcgagacg gaacacgtcg aagaagtcgc
    25321 cgcccacctg gtcggcggag gcgacgtggt agtgcgtggc gatgtccagc ccggggacct
    25381 tcggcgggga gggcgggagc agcaccttgc gcagcgtgga ggtgagcagt tccagccggc
    25441 cgcgctcggc ctcggcctgc tggcgcaggc ggcgttcgag cgtgagggcg gcgcgggcgg
    25501 acagccgcgt ctccagctgg gtggccacca gggcggccag gtcggtcagc gtgtgcagtc
    25561 cggcttcgtc cacctcgcgc ggctcgacgt ccatgacgtt gaccgtgccc aggcggtggc
    25621 cgtcggccgt gacgatcggc gcggcggcgt agaaccgcac atggggctcg tcacggacca
    25681 gcgggtggtc gcacgcctcc gggtgggtga gcgtgtcggc caccacgtac ggttccgact
    25741 ccaggatcgc ggagacgcac aggccggggt cgggcgcgag gtcgtgcggg acccccgcca
    25801 gccccgtgtg ggccttgatc cagacccgct cgtcctcgac gaacgtcacg gacgcgatcg
    25861 gcgcgccgaa ggcgcgggcc gcgagcgcga cgacccggtc gaacgccccc tcgggcgggg
    25921 tgtcgaggac ctggtaccgg cgcagcgctt ccagccgcgc ggcctcggcg ccaggatcga
    25981 tcagcgttgc cgtcatgtgg tcgcgtcacc gtttctcttt cgaggacgca cgaagtttac
    26041 ttgtcaagct tctctgctcc cgccggattt actacaaaac ccccaatacc cccaacattc
    26101 ccaaaagatc ccgcgtgaag acggatcgcc ggttcgacgg agtaccaatg tgaccccgtc
    26161 gaagggaccc agccggatga ccgctccacc cgga
//
