LOCUS       NZ_WQMW01000024         8442 bp    DNA     linear   CON 07-APR-2024
DEFINITION  Bacillus paranthracis strain ELWA-3_3298 Contig24, whole genome
            shotgun sequence.
ACCESSION   NZ_WQMW01000024
VERSION     NZ_WQMW01000024.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus paranthracis
  ORGANISM  Bacillus paranthracis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 67608)
  AUTHORS   Matson,M.J., Anzick,S.L., Feldmann,F., Martens,C.A., Drake,S.K.,
            Feldmann,H., Massaquoi,M., Chertow,D.S. and Munster,V.J.
  TITLE     Bacillus paranthracis Isolate from Blood of Fatal Ebola Virus
            Disease Case
  JOURNAL   Pathogens 9 (6), 475 (2020)
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 67608)
  AUTHORS   Matson,M.J., Feldmann,F., Anzick,S.L., Martens,C., Massaquoi,M.,
            Sprecher,A., Giuliani,R., Edwards,J.K., Drake,S., Feldmann,H.,
            Chertow,D.S. and Munster,V.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-DEC-2019) Research Technologies Branch/RML Genomics
            Unit, National Institute of Allergy and Infectious Diseases, 903
            South 4th Street, Hamilton, MT 59840, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-AUG-2019
            Assembly Method                   :: MIRA v. 4.0.2; Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 32.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013357905.1-RS_2024_04_07
            Annotation Date                   :: 04/07/2024 07:43:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,895
            CDSs (total)                      :: 5,741
            Genes (coding)                    :: 5,493
            CDSs (with protein)               :: 5,493
            Genes (RNA)                       :: 154
            rRNAs                             :: 13, 15, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 13, 2, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 13, 12 (16S, 23S)
            tRNAs                             :: 107
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 248
            CDSs (without protein)            :: 248
            Pseudo Genes (ambiguous residues) :: 0 of 248
            Pseudo Genes (frameshifted)       :: 85 of 248
            Pseudo Genes (incomplete)         :: 165 of 248
            Pseudo Genes (internal stop)      :: 39 of 248
            Pseudo Genes (multiple problems)  :: 34 of 248
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:58:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 59166
            Orig. end                         :: 67608
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WQMW01000024.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..8442
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..8442
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..8442
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5538](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5538)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            154..804
                     /locus_tag="GI596_RS22845"
                     /old_locus_tag="GI596_22610"
     CDS             154..804
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002119627.1"
                     /locus_tag="GI596_RS22845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_22610"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_175251860.1"
                     /sec_met_domain="Abi (E-value: 3.4e-11, bitscore: 35.7,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METRIIETEKKIDSKSLLALGLLIISGIVYQLFSFVGGIPGLLRM
                     IIEASWNLILCGIIGYYFLGKISLEQFKHFNFKTLLLGIPLTIIVGMGSTSIFNYIFEP
                     ATQNSVAEVISISMILFRVPFMLMGEELICTNIIIALQKLGLKFGTASIICSVLFALWH
                     IPAYGFVPLQLLITIIPARLALNYIWKNSKSVWVSWICHFVFDILGFLPMLFK"
     gene            complement(1900..2061)
                     /locus_tag="GI596_RS22850"
     CDS             complement(1900..2061)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000901478.1"
                     /locus_tag="GI596_RS22850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000901478.1"
                     /transl_table=11
                     /translation="MLGRIVSLLFILGCVIYYVTTTPSEEISFLKLLLIPLVLVVGYFI
                     DKKLGEEK"
     gene            complement(2076..2723)
                     /locus_tag="GI596_RS22855"
                     /old_locus_tag="GI596_22615"
     CDS             complement(2076..2723)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413076.1"
                     /locus_tag="GI596_RS22855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_22615"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_000413076.1"
                     /transl_table=11
                     /translation="MEKLIINNLDYSYENQDELFSQVNICLDKGSKVRLFGENGSGKTT
                     LLKIIANIIEDEETLSYELNYFGENATFSDIREKRVFIADSPTFYEELTMEQNIQFYNL
                     FFNYGEGFLENVYKVCKKFNVYSYLKQSVKNLSLGTRQKIWLAINLSTPTELVLLDEPF
                     NSLDKESRRILSKVINESTDRTFIIVSHENNEGVLFSHELNSNNWSVSQLTM"
     gene            complement(2745..3269)
                     /locus_tag="GI596_RS22860"
                     /old_locus_tag="GI596_22620"
     CDS             complement(2745..3269)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000874707.1"
                     /locus_tag="GI596_RS22860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_22620"
                     /product="stage II sporulation protein M"
                     /protein_id="WP_000874707.1"
                     /transl_table=11
                     /translation="MAFKNRFLIYRKFFIASLVIYILSFISGALISNFLNFDLLPHAEA
                     FDDLLYHNLILGLKLMVFGWISLGVLNTICLGYNGIFLGTLTFSIVKHHGFTPILTGIL
                     PHGIIEIFAFLLFSTIGFESLRYVDFLKKKAKHDNKITYQKSIKNSIFVIVLAVILLLI
                     AAWIETYISHI"
     gene            complement(3295..4926)
                     /locus_tag="GI596_RS22865"
                     /old_locus_tag="GI596_22625"
     CDS             complement(3295..4926)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001993466.1"
                     /locus_tag="GI596_RS22865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_22625"
                     /product="hypothetical protein"
                     /protein_id="WP_001023491.1"
                     /transl_table=11
                     /translation="MNILKLVGLHILNSYQRKGYLLKKLLRFKSIKKYIAFSLIFDTCF
                     SLFLVYLLSRFLLPSYETIFVIIALILSTYHVISIVAKSKQQLDKEYLISHFMSYVNDK
                     YTLIKKVIIIDWMVGLFHSLTALIPISFFILFETKEYSYFPLLILVHVTLFSLNLLFKS
                     SAQKKWFSTIIHIILKGVLGLVTYAGASIFINIISITRRNIDLYGYKLKAISNLNDQTN
                     DILTHSSIYQFYKKIEGLYNNYINFSGVAIAIGMLFILSLIVFKYSRNFKDRHFKIKFS
                     DNLYNGLNKDHYYTFADYYTLKNMSTSLKNNPLDLYLTGELAMSIGISLATVQYVHNEI
                     LIILIMFFQLHLIFKGVIGTTSHVYSKVFKFEQECSMLSLFNIHDIKKSDILLSKYELL
                     KRTSTLYLLINLLIFLIATILISPKQSLALLIVLLPFLFMKNEYVLYSLRTNFDVFAML
                     SSEKNPPEISKLNEFNGYTLIATSNNMLSRLIMQFVVLGFILTGTFKLVSGMSWIYILF
                     IVCLAIFIQVIISNRDYKSFKLNKKQ"
     gene            complement(5001..5228)
                     /locus_tag="GI596_RS22870"
                     /old_locus_tag="GI596_22630"
     CDS             complement(5001..5228)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IId"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000362895.1"
                     /locus_tag="GI596_RS22870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_22630"
                     /product="uberolysin/carnocyclin family circular
                     bacteriocin"
                     /protein_id="WP_000362895.1"
                     /sec_met_domain="Bacteriocin_IId (E-value: 5.3e-20,
                     bitscore: 63.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLFHVASKLSISKGVAAGVVSTVLNAGTLITAIGAVTVALSGGI
                     DAILEVGWATFVATVKEQAAKRGTAGAVAW"
     misc_feature    5267..5281
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 18.44"
                     /tool="antismash"
     gene            complement(5311..5538)
                     /locus_tag="GI596_RS22875"
                     /old_locus_tag="GI596_22635"
     CDS             complement(5311..5538)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IId"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522372.1"
                     /locus_tag="GI596_RS22875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_22635"
                     /product="uberolysin/carnocyclin family circular
                     bacteriocin"
                     /protein_id="WP_000522372.1"
                     /sec_met_domain="Bacteriocin_IId (E-value: 1.5e-20,
                     bitscore: 65.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLFHVASKFKISQGIAGGVVAAVLNAGTLISAIGAVTVVMSGGI
                     DAILEVGWTAFVATVKEQAAKRGTAGAVAW"
     gene            complement(5729..6394)
                     /locus_tag="GI596_RS22880"
                     /old_locus_tag="GI596_22640"
     CDS             complement(5729..6394)
                     /GO_function="GO:0031267 - small GTPase binding [Evidence
                     IEA]"
                     /GO_process="GO:0006888 - endoplasmic reticulum to Golgi
                     vesicle-mediated transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001993453.1"
                     /locus_tag="GI596_RS22880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_22640"
                     /product="Yip1 family protein"
                     /protein_id="WP_000126703.1"
                     /transl_table=11
                     /translation="MTAQIEAVKKEKPSLIGSIISPTVQFEKMRDSNKIWGAFFLLIIL
                     GGIIGALASYVSVNSPQMLKMLATPPTTQDKNIAVGTGLLLGVLGTALTLLITALFYRV
                     IMMFMSNDTPYKKILAIIVYASLIKYMGSIINIVLAFILGGKGTEKYTSLGPLFETGTV
                     ASGIGNTFEIFSIWGLILTGIGLHITAGISKKQATILIIILFIISLGFNSLTGLVPKM"
     gene            complement(6530..7729)
                     /locus_tag="GI596_RS22885"
                     /old_locus_tag="GI596_22645"
     CDS             complement(6530..7729)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017674431.1"
                     /locus_tag="GI596_RS22885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_22645"
                     /product="ABC transporter permease"
                     /protein_id="WP_000054384.1"
                     /transl_table=11
                     /translation="MSLLDSIKIALSSILAHKLRSALTMLGIIIGVGSIITVVAIGQGG
                     EAMLKSQFVGSGSNVIPINFKADINNSFGLEGNSQPPLTEEDIFEIKKLPQISNVITSN
                     STMETLDINDKKEMTNIIGIDINYFSVNKIKVLKGRALNDMDINQGNNVILISKALEEK
                     MYSKESPIGKIIEIKGQPMQIIGVYQSDNEFMGIGMSEAFVPLTLWPTLYGKEEIQNIS
                     IQAKNVDEMESSGKKAVDILNSRKPSDIPGEYEVVNLEAMQKNISKVTGIMTMIIGGIA
                     GISLVVGGIGVMNIMLVSVTERTREIGIRKALGATRSKILLQFLIEAVMLTLLGGLIGI
                     GLGYGGAYIVAKFAKWPPLVSWEVVVGGVLFSMILGIIFGLLPANKAAKLDPIEALRYE
                     "
     gene            complement(7726..8406)
                     /locus_tag="GI596_RS22890"
                     /old_locus_tag="GI596_22650"
     CDS             complement(7726..8406)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000631604.1"
                     /locus_tag="GI596_RS22890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_22650"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000631624.1"
                     /transl_table=11
                     /translation="MITLNNIAKTYYQGKLAVPILHGISLTIQSGEFVSIMGPSGSGKS
                     TLMNIIGCLDRPTEGEYMLNDVNILTADESKLALIRNEYIGFVFQHFNLLPRLSAVENV
                     ELPLVYGGVKKAERRKRALEALGKVGLADRVHHLPNELSGGQKQRVAIARAIANNPTFI
                     MADEPTGALDTKSGEQVMDIFTKLNAEGTTIVMVTHEEEVAAYSSRRIVLRDGKVTEDR
                     RCAV"
ORIGIN
        1 aaaattgttt gaatttagaa ccataaattt atcgcaatta tacaacgata ttaaacaaaa
       61 attattgtac tcgttgtaat caccattaat taggagggat atatgttact atatatttgt
      121 aattcacaaa acaataagaa agaaggtgtt attgtggaaa caaggattat agaaactgag
      181 aagaaaattg attcaaaatc tcttttggct ttggggttat taatcatttc cggcattgta
      241 tatcaacttt tttcatttgt agggggtata cctggattat taagaatgat tattgaagct
      301 tcatggaatc ttatattatg tggaattatt ggatactatt ttttaggtaa aatatcatta
      361 gagcaattta aacattttaa ttttaagaca ttacttttgg ggataccttt aacgattatc
      421 gtgggtatgg gttccacctc aatattcaac tacatttttg aacctgcaac tcaaaattct
      481 gtcgctgaag taataagtat ttctatgatt ttattccgtg taccatttat gttaatgggc
      541 gaagagttga tttgcacgaa tataattatt gcattacaaa aattaggatt gaaatttggt
      601 acagcatcaa taatatgtag tgttttattt gctttgtggc atattcctgc ctatggtttc
      661 gtgccactgc agttattaat aactataatc ccagctagat tagcactaaa ttatatatgg
      721 aaaaattcaa agagtgtttg ggtaagttgg atttgccact ttgttttcga tattttaggt
      781 tttttgccaa tgctttttaa ataaaaaata actctactta taaataacaa acaataacat
      841 aaacaaaaaa agaaccttaa ggttcttttt ttacttattc ttattcagaa catgtaagga
      901 tagcatcata tcgctatcaa gctaataaaa taaaggtatg cattttcact attggattcc
      961 tatctttgga accataaatt tgccacaaac aaaaagaacc ataacctcgc caacctagca
     1021 aagttatggt tcatatcata ctgtgattta aaccataact tttccatgta aataaagcat
     1081 aaactttcca caattacagc cacgtagctt caagacattt tctaaccaaa ttttccaact
     1141 tccttttcat ttctcttccc ataaaattga gtaatttatc ctcatttaaa tatttttagg
     1201 aaagcttatg ccttactttt tgtctctagg aaattttatg gtttattcaa atccttaaaa
     1261 aatgccactc tacctaactc ctttgtctaa ttatcgccac tatataatat agaagaaact
     1321 tatctaaatt ggaaaagtaa cgagatgcgt agggttactt ttatgcaact attagaacta
     1381 aagaaaaaga caggttataa aatactaaaa gaatatgaag gtatatttga ccagttataa
     1441 gctagtttcc ttttattaaa gagtgattaa aaatcgtcta gattccttta gagttatata
     1501 cccgtaccta actagataat attttaaatt tcatctcggc atccaacctc attagtgttt
     1561 aattacgctc ttatttaaat tatttagttt gttggattcc acaattatta attaattttt
     1621 atgtaacaaa gagaaaagca tccagatagg atgctttttg tgtttgcacg aggtccttta
     1681 tttggatttg ttgtatgtca aattcttatg caacctcata ctttttttag tcaatttcaa
     1741 aaagttattc tacatctact aaagctcgaa acaacttttc accatatata ctaaatattt
     1801 aaatttaatt ttagattagc atccataaat gatttactaa tttattaaaa agacaattat
     1861 aagtatatac atacaaaata attgtctttt taataaagtt tatttttctt cccctaactt
     1921 tttatcaata aaatacccaa caactaaaac taagggaatc aataataatt ttaaaaatga
     1981 aatttcttct gatggtgtag ttgttacata ataaatgacg catcctaaaa tgaacaataa
     2041 agaaactatt cttcctaaca taaattcacc ctttatcaca tagttaattg actaacagac
     2101 caattattac tatttaactc atgggaaaat aaaactcctt cattattttc atgagaaacg
     2161 ataataaagg ttctgtctgt gctttcatta ataaccttcg ataaaatcct tctactttct
     2221 ttatctaaag aattaaatgg ttcatctaat aaaactaatt ctgttggggt ggacaagtta
     2281 attgctaacc atatcttttg tcttgttccc agagataaat tttttactga ttgttttaag
     2341 taagaataaa cattgaattt tttacaaact ttataaacat tttctaaaaa cccttctcca
     2401 taattaaaaa ataaattata aaattgaatg ttttgttcca tagttagttc ttcataaaat
     2461 gttggagaat cagcaataaa tactcttttt tctctaatat ccgaaaaagt tgcattttct
     2521 ccaaagtagt ttaattcata tgaaagtgtt tcttcatctt ctattatatt agcaattatt
     2581 ttaagaaggg tagttttacc agaaccattc tctccaaaca acctaacttt gctaccttta
     2641 tctaaacaga tattaacttg gctaaacaat tcatcttgat tttcatatga atagtctaga
     2701 ttatttatta ttagcttttc catatctctt taataacctc cgccttaaat atgagaaata
     2761 tatgtctcta tccatgctgc tatgagtaat aaaattacag ctaaaacaat tacgaaaatt
     2821 gaatttttaa tcgatttttg ataagtaatt ttattatcat gctttgcttt cttttttaaa
     2881 aagtcaacat aacgtaatga ttcaaaccca attgttgaga acaataaaaa cgcaaagatt
     2941 tcaataatac catgtggtaa tattccagtt aaaataggag taaacccatg atgtttaact
     3001 attgagaaag tcaaggttcc tagaaaaatt ccgttatatc ctaaacaaat cgtattcaaa
     3061 acccctaaac taatccatcc aaaaaccatt aatttcaatc ctaaaataag gttatgataa
     3121 agtaaatcat cgaaagcttc tgcatggggt aacaagtcaa aatttaaaaa atttgaaatc
     3181 aaagctccag aaataaaact gagtatataa atgactaaag atgctatgaa aaattttctg
     3241 taaatcaaaa atctattttt gaaagccata ttgtctcctt ttcttctata atgattattg
     3301 ttttttgttc aatttaaatg atttataatc tctattacta atgattactt gtataaaaat
     3361 tgccaaacaa acaataaata gaatatagat ccatgacatg ccacttacaa gtttaaacgt
     3421 accagttaat ataaatccta aaactacaaa ctgcataata agtctagata gcatgttatt
     3481 agatgtagca attaatgtat atccgttaaa ttcgtttaac ttgctaattt caggaggatt
     3541 tttttctgaa gatagcatgg caaaaacatc gaaatttgta cgcaatgaat ataaaacata
     3601 ttcatttttc ataaataaaa aaggtaacaa tacaattagt aaagcaagtg attgctttgg
     3661 tgaaataagt atagttgcaa ttagaaaaat taataagttt attaataaat ataatgttga
     3721 tgttcttttt aaaagttcat atttagatag taaaatgtcc gatttcttta tatcgtgtat
     3781 attaaataat gaaagcattg aacactcttg ttcaaacttg aaaacttttg aataaacatg
     3841 acttgttgta ccaattactc ctttaaagat taaatgtaat tggaaaaaca ttatcaatat
     3901 aataagaatt tcattatgaa cgtactgaac tgtcgctaaa gaaattccaa tgctcatagc
     3961 taactctcct gttaggtata aatccaatgg attattctta agagaagtag acatgttttt
     4021 taaggtataa taatctgcaa atgtataata atgatcttta tttagtccat tatatagatt
     4081 gtcactgaat ttaattttaa aatgtctatc tttaaagttt ctagagtact taaagacaat
     4141 taaactaaga ataaataaca ttcctatagc tatagctaca ccactaaagt taatataatt
     4201 gttgtatagt ccttcaatct ttttgtaaaa ctgataaata cttgaatgag ttaaaatgtc
     4261 gttagtctga tcattcaaat tagatatagc ctttaattta taaccataca aatcaatatt
     4321 acgtctagtt atggagatta tattaataaa tatggatgct cctgcgtacg ttacaagacc
     4381 taaaacaccc ttcaaaatta tatgaatgat ggtactaaac catttcttct gagccgatga
     4441 cttaaataag agatttaaag aaaataatgt tacatgtaca agaattaaca atggaaaata
     4501 agagtattct tttgtttcaa ataaaataaa aaaggaaatt gggataaggg ctgtcaaact
     4561 atgaaataat cctaccatcc agtcaataat tattaccttt tttatcaagg tatacttatc
     4621 attaacataa gacataaagt gggaaatgag atattcttta tccaattgtt gtttagattt
     4681 tgcgacaata cttataacat ggtaggtgga caaaattaaa gctatgataa caaatatagt
     4741 ttcataactt ggtaataaga atctagaaag taagtacact aaaaatagtg agaaacaggt
     4801 atcaaaaatc aaactaaatg ctatatattt tttaatactt ttaaatctta aaagtttctt
     4861 taataaatac ccttttcttt gataagaatt taagatatgt aaaccaacta atttcaatat
     4921 gttcatttat tcaatctcct tatttaaaac taaaacagct aggacataga ttcctagctg
     4981 ttttaagctt taatgctttc ttaccaagca actgcgcccg cagtaccacg tttagccgct
     5041 tgttctttaa ccgttgctac gaaagtagcc cagcccactt caaggatagc atcaatgcca
     5101 cctgataatg ctaccgttac tgctccaatt gcagtaatta aagtacctgc atttagtaca
     5161 gtagaaacaa ctccagctgc aacaccttta ctaatgctta acttacttgc tacatgaaat
     5221 aaatccatct tgaatctctc cctgtttaat atttaatttt cttaagtggt aacgattcca
     5281 tattgttcaa atcaatatga gaattaaatc ttaccaagca accgcgcctg cagtaccacg
     5341 ttttgctgct tgttctttaa ctgttgctac gaacgctgtc caacctactt caagaatagc
     5401 atcaatacca cctgacataa caactgttac tgcaccgatt gcactgatta aagtacctgc
     5461 atttaatact gccgcaacaa cgccacctgc aataccttgt gaaattttaa acttacttgc
     5521 tacatgaaat aaacccatct gaaatccctc tttcttaata taaagatata taatttgaaa
     5581 tatttctgga taataatacc acgatattct aaaaaaagta aatacataaa ttacattata
     5641 tttataatta atctgacaag ttttacacta ggtgaaataa aatttgtaaa atattacagt
     5701 aaattaagta tacttattac atagaatatt acattttagg tacaagtcct gttagactat
     5761 taaaaccaag agagataata aataaaataa taataagaat ggttgcctgt tttttgctaa
     5821 taccagccgt aatatgcaaa cctattcctg ttaaaattaa tccccaaata gaaaatattt
     5881 caaaggtatt tccaattccg ctagcgacag taccagtttc aaacaaagga cctaaacttg
     5941 tatatttttc tgtacctttt ccacctaata taaatgctaa aactatgtta ataattgagc
     6001 ccatatattt aatcaagctt gcataaacaa taatagctaa tattttttta taaggcgtat
     6061 cattgctcat aaacatcata attactctat agaataatgc tgttataaga agggttaaag
     6121 ctgtacctaa tacgcctagt aacaatccag ttcctactgc aatgttctta tcttgggtcg
     6181 ttgggggagt tgctaacatt tttaacattt gtggactatt tactgacaca taactagcta
     6241 gcgctcctat aatccctccc aaaattatta ataagaaaaa tgctccccaa atcttattac
     6301 tgtccctcat tttttcaaat tgaacagttg gtgaaataat actcccaatt aaagatggtt
     6361 tttctttctt tacagcttcg atttgtgctg tcattttggt tcactcctca tttttgtgta
     6421 gtatattttc aagaaacaag tatgtttagt atcaaaaatc aactgaaaaa cttatctctt
     6481 gaaaattaat atatatatag aggtatcatt cctcttatac atcaaaaaat cactcatatc
     6541 gtagtgcttc aattggatct aatttggcag ctttattcgc tggaagtaat ccaaaaataa
     6601 ttccaagaat catagagaac agcaccccgc caacaacaac ttcccacgat acaagcggtg
     6661 gccatttagc aaattttgca acgatatatg cgcctccata tcctaggcca attccaatta
     6721 atccaccaag gagggttaac ataacagctt caattaagaa ttgtagtaag attttactcc
     6781 ttgttgcacc aagagctttg cgaatcccaa tttcacgtgt acgttcagtc acagatacta
     6841 acataatgtt cataacacca attccaccta caactaaaga aatacccgca atcccaccaa
     6901 taatcatcgt cataataccc gtgactttag aaatgttttt ttgcattgct tctaagttaa
     6961 caacttcata ctcaccaggt atgtcactag gtttgcgact atttaatata tctacagctt
     7021 tttttcctga agactccatt tcatcgacgt tctttgcttg tatagagatg ttttgaattt
     7081 cctctttccc atacaatgta ggccataatg ttagtggaac aaaagcctca gacataccaa
     7141 ttcccataaa ctcattatca gactggtaaa cgccaatgat ttgcatcggt tggcctttta
     7201 tttctatgat tttccctata ggactttctt tggaatacat cttttcttct aaagctttac
     7261 taatcagaat tacgttattt ccttgattaa tatccatatc atttaacgct ctgcccttta
     7321 aaactttaat tttattaaca gaaaagtagt taatatcaat tcctataata tttgtcattt
     7381 cttttttatc atttatgtcc aatgtttcca ttgttgaatt actagttata acatttgata
     7441 tttgtggtaa ttttttaatt tcaaagatat cttcctctgt taggggaggt tgagaatttc
     7501 cctctagacc aaatgagtta ttaatatctg ccttaaaatt aattggaatt acattactac
     7561 ctgagccaac aaattgtgat tttaacatcg cttctccacc ttgtccaatt gccacaacag
     7621 taataataga tcctacacca attataatac caagcatcgt aagagctgaa cgcagtttat
     7681 gagctaaaat agaagataag gcaattttta tactatctag taaactcata ccgcacacct
     7741 tctatcttct gtaactttcc cgtctcgtag tacaatgcgg cgggaagaat acgctgctac
     7801 ttcctcttca tgtgtaacca taacaatcgt cgtaccttct gcattaagct tcgtgaaaat
     7861 atccataact tgctcaccag acttcgtatc aagtgcacca gtcggttcat cggccataat
     7921 gaacgttggg ttattcgcaa tcgctcttgc aatcgctaca cgctgcttct gtccacctga
     7981 taactcattt ggtaaatgat gcacgcgatc tgccaatcca actttaccta gcgcctccaa
     8041 agcacgcttg cgacgctccg ctttcttcac gccaccatat acgagcggaa gctcaacatt
     8101 ttccactgct gaaagacgag gtagtaaatt aaaatgctgg aatacaaagc caatatattc
     8161 attacgaatt aaagcaagct ttgactcgtc tgctgttaag atattcacgt cattcagcat
     8221 atattcgcct tctgttggac gatctaaaca accgataata ttcataagcg tcgacttacc
     8281 agaaccagac ggtcccataa tcgaaacgaa ctcaccactc tgaatcgtta aactaatacc
     8341 atgcaaaatc ggcactgcca attttccttg ataatacgtt ttagcaatat tatttaacgt
     8401 aatcatttct ctttcacttc cattccgtca tacacatcgt cg
//
