LOCUS       NZ_WQMW01000016        23213 bp    DNA     linear   CON 07-APR-2024
DEFINITION  Bacillus paranthracis strain ELWA-3_3298 map unlocalized plasmid
            unnamed1 Contig16, whole genome shotgun sequence.
ACCESSION   NZ_WQMW01000016
VERSION     NZ_WQMW01000016.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus paranthracis
  ORGANISM  Bacillus paranthracis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 120689)
  AUTHORS   Matson,M.J., Anzick,S.L., Feldmann,F., Martens,C.A., Drake,S.K.,
            Feldmann,H., Massaquoi,M., Chertow,D.S. and Munster,V.J.
  TITLE     Bacillus paranthracis Isolate from Blood of Fatal Ebola Virus
            Disease Case
  JOURNAL   Pathogens 9 (6), 475 (2020)
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 120689)
  AUTHORS   Matson,M.J., Feldmann,F., Anzick,S.L., Martens,C., Massaquoi,M.,
            Sprecher,A., Giuliani,R., Edwards,J.K., Drake,S., Feldmann,H.,
            Chertow,D.S. and Munster,V.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-DEC-2019) Research Technologies Branch/RML Genomics
            Unit, National Institute of Allergy and Infectious Diseases, 903
            South 4th Street, Hamilton, MT 59840, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-AUG-2019
            Assembly Method                   :: MIRA v. 4.0.2; Velvet v. 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 32.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013357905.1-RS_2024_04_07
            Annotation Date                   :: 04/07/2024 07:43:32
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,895
            CDSs (total)                      :: 5,741
            Genes (coding)                    :: 5,493
            CDSs (with protein)               :: 5,493
            Genes (RNA)                       :: 154
            rRNAs                             :: 13, 15, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 13, 2, 2 (5S, 16S, 23S)
            partial rRNAs                     :: 13, 12 (16S, 23S)
            tRNAs                             :: 107
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 248
            CDSs (without protein)            :: 248
            Pseudo Genes (ambiguous residues) :: 0 of 248
            Pseudo Genes (frameshifted)       :: 85 of 248
            Pseudo Genes (incomplete)         :: 165 of 248
            Pseudo Genes (internal stop)      :: 39 of 248
            Pseudo Genes (multiple problems)  :: 34 of 248
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:58:54
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 81486
            Orig. end                         :: 104699
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WQMW01000016.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23213
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..23213
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="neighbouring"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..20150
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="single"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20150
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10150](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10150
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     cand_cluster    452..23213
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    452..23213
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10451:13213](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10452..13213
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
     gene            <921..1940
                     /locus_tag="GI596_RS19490"
                     /old_locus_tag="GI596_19275"
                     /pseudo=""
     CDS             <921..1940
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016100209.1"
                     /locus_tag="GI596_RS19490"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19275"
                     /product="ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="RGNWTEDLHGLEGKVNVITLGTDRRDEGKLDPFIIHKHSRKDAIE
                     LAMTILTFITGIKPDNSEKFPRLASAVEFVAGMEEPCLTAVSQYLEDSEDKVDQQLAAH
                     IQAFENLSFAHLIFGDGTNRDIELDTAVNIIQIQHLDMPDIQKDPKDYTLQENLSVSML
                     MSLSSFARKFFQKDPTKFKIVLLDEAWAIMGTSQGRELARKLVREGRALNSAVYFATQS
                     ASDLGDETFKNNIGMKFSFRNTDSKEISSILDFFGLPDNEENHAIVTNLETGQCLFQDI
                     QGRTGVVTMDVVFKDLYDAFDTRPNARKNYRKSNDDEKQEVNATFVEEGGEKINVGVS"
     gene            1942..2424
                     /locus_tag="GI596_RS19495"
                     /old_locus_tag="GI596_19280"
     CDS             1942..2424
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001971723.1"
                     /locus_tag="GI596_RS19495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19280"
                     /product="hypothetical protein"
                     /protein_id="WP_000241151.1"
                     /transl_table=11
                     /translation="MVKTKLKKLMLSSLCAGALILSAACGNSETNVGEEKDKQGHTPRE
                     MMLDFVKADLQHDYKTIRKLVVDGEKNKILDPNKGPQNNLSYKDYTVKEYVVDKDTIMY
                     NFISKKPPKNIDKAVKWIRVVRTDDGFKVRSYTGPERNEIDEVANTKPTNEFSSKD"
     gene            2457..5057
                     /locus_tag="GI596_RS19500"
                     /old_locus_tag="GI596_19285"
     CDS             2457..5057
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713569.1"
                     /locus_tag="GI596_RS19500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19285"
                     /product="membrane protein"
                     /protein_id="WP_046947113.1"
                     /transl_table=11
                     /translation="MKKFITLLLLICTLLLAFNLLFKAAPVYAEEEPRPSLIDDIIPKN
                     KEKLKYEEYPPSSYGIDVYTPEGGFGESLKFWKWKDNIKEQIVATIFILISIGWSVNLA
                     ISSFVTSMVGQSMSLNIVADVGDKLGDVISKAAGFNGSWGNGIYSELIGLMLALLACWV
                     IWVGFVQRRQSEMLGGLLKTLGILVFTLAFFANSSYIIKGLNTFSEQVNKTVLDSTQSI
                     SGASEGYSSGVDSITDLTHTLLIKQPYTLLQFGTTDMKKIGDERIKKMLTTTDPDERKA
                     LLKDEVEVQKNQTLSLDATFERGALVLLLGAINLPLWIVLGLCSMAMLFYQLMFIIVAL
                     MSPVMLLMALVPAWTGTAKKFLSELFRTLLMKVAIGFLVTLMFWVSSILFSATDKYGYL
                     VVAALQVLSFLGVWLYRKTIFDAITTVPASAGAARASDAMSNIRQKYRDVRRGSKTVGR
                     GVAVAGAAGLASAAVAGKVGKSGYSKFKQLKENYADRKEKVADGKRKEKEQMQAEKEKN
                     INQMKKEENLGVRDRKGNQEQERVKEEVAATKENPELAVRGQHQDNNPEMQQAELKDKE
                     EDVKADVQPVAQSNDELNNKEEDVKAQVRPVANQNSSGLENKQEDVKAEAKPGATIKTP
                     TGQTKPITTPLSGTTPLQSSPMESKPITTPQSGTTPLQSSPMESKPITTPQSGPTPLQS
                     NPMESKPITTPQSGPTPLQSNPMESKPITTPQSGPTPSPANPVESKPITTPQSGPTPSS
                     ANPIESKPITTPQSGPTPSPANPVESKPITTPQSEPTPANPMESKPVTTSHVSTPQKQV
                     EVKSVNQQQTKSVPKVNNQQQVKEGAAIKKVETKAQTQQEALKNVKAKETIKPK"
     gene            5085..6296
                     /locus_tag="GI596_RS19505"
                     /old_locus_tag="GI596_19290"
     CDS             5085..6296
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001271980.1"
                     /locus_tag="GI596_RS19505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19290"
                     /product="bifunctional lytic transglycosylase/C40 family
                     peptidase"
                     /protein_id="WP_001271974.1"
                     /transl_table=11
                     /translation="MSAEPNRDFENEHHPEAELGNAKPALKKAGHSLGKAAGKGSKIAG
                     KAVAQVSKKVAVKVAQKAATVAVAKPLLIIAGVILAVVAGLGIVIFLLTATMGEDEVSP
                     GGIGGPFTPGTASVSPEVMRWEPLVRKYAAQHGIEAMTPLILALIQQESSGTQLDVMQS
                     SESQGYGPGYFTDPEESIKYGLMHFADCHKKSNGDPNITLQCYNYGTGYANYALSNGGY
                     THANARAFSAEQTAKTGYKCASWRSAEAVANNWCYGDPDYVPHVLRYYQGGSGGGPVAG
                     GDELFKKVMDEAIKYQGWPYVWGGRTPQSSFDCSGLIQWVYGQAGINLVGTAETQFKMT
                     QRTNDPQPGDLIFFQGTYKPGISHIGIYVGNNRMFHAGDPIGYADLNTPYWQQHFAGYG
                     KVAR"
     misc_feature    complement(5111..5125)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.24"
                     /tool="antismash"
     gene            6307..6903
                     /locus_tag="GI596_RS19510"
                     /old_locus_tag="GI596_19295"
     CDS             6307..6903
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724391.1"
                     /locus_tag="GI596_RS19510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19295"
                     /product="hypothetical protein"
                     /protein_id="WP_000753850.1"
                     /transl_table=11
                     /translation="MKKTTILLIVLLIGSIGLNFKINADNAQLKDEKAKLSKKIQKVES
                     QYKDTEKELQALKSNNQQQVKEAAERFLKAFRTYDTGKGESYITNVEAYITPNAKKELT
                     PPGAPNPPASSTAEEKDKKKLAFKSEYIGGELYYAFIDTTKANVLAKVKSKMIINGVSS
                     ENMSLMQINLIYDGNKKLWLVDKVIPLADLRDQMP"
     misc_feature    7416..7433
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.32"
                     /tool="antismash"
     gene            <7434..7574
                     /locus_tag="GI596_RS29475"
                     /pseudo=""
     CDS             <7434..7574
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018765639.1"
                     /locus_tag="GI596_RS29475"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="sporulation protein YhbH"
                     /pseudo=""
                     /transl_table=11
                     /translation="LNQYNRSSSTFFYKNIEDEKFRYYILKNKADVYRCLKTFFLKGRL
                     I"
     misc_feature    complement(7464..7477)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.21"
                     /tool="antismash"
     gene            7847..8086
                     /locus_tag="GI596_RS19515"
                     /old_locus_tag="GI596_19300"
     CDS             7847..8086
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000676622.1"
                     /locus_tag="GI596_RS19515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19300"
                     /product="hypothetical protein"
                     /protein_id="WP_000676621.1"
                     /transl_table=11
                     /translation="MKGKINKITQSLQLEIFKMLTNSPSLRLILRGAGVTFVIIFGTAL
                     TKQPTVFSINFVMIILGFFLIFMPYIFRNYKKLN"
     gene            8421..9278
                     /locus_tag="GI596_RS19520"
                     /old_locus_tag="GI596_19305"
     CDS             8421..9278
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="GI596_RS19520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19305"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_033693696.1"
                     /transl_table=11
                     /translation="MDKILNVKGLSKKYNDFHLHHINFELKRGSITGFIGENGAGKSTT
                     IQSILNIIDYDSGEILFNGESFQQNRNDLKKRIGYVGDNNKFYDDVKLKVIRNFVKDAY
                     LEYWDDKFSEYLVKDVFNLNLNMKIKELSKGMRAKFLLTLAMSHNPDLLILDEPTSGLD
                     PIVRNQLLEILNDIAEKKGTTIFFSSHITDDIEKIAQKIIYLDNGSILLDEEKAAIFNR
                     FKKIPIDKINSIQIEKLKEIGVLVQDHIVVDKQVLKEQDIYDLNLEKVVLDEVLLLLKK
                     QKMN"
     misc_feature    complement(8460..8475)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 25.49"
                     /tool="antismash"
     gene            9324..9956
                     /locus_tag="GI596_RS19525"
                     /old_locus_tag="GI596_19310"
     CDS             9324..9956
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024741.4"
                     /locus_tag="GI596_RS19525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19310"
                     /product="ABC-2 transporter permease"
                     /protein_id="WP_033693697.1"
                     /transl_table=11
                     /translation="MFAILKKDILINQKYLLIVLLYSIIFPVILIIDGDNKYLMMSFLL
                     PFINVNFFVGKSCYIEDSVDVRNFLKMLPINHNKIVFIRYIEMIVTLALSSVYAFLVQL
                     YLMNGVSNAFLIHVNLLVFSALLIYFGIYLSVYYKINYHAAQNTLMFLFVIGVSTFILT
                     EKVFNIKIEMINHLNYSASYIAFVISIIVLSITYLYSIKEFKFNKFA"
     gene            10001..10150
                     /locus_tag="GI596_RS19530"
                     /old_locus_tag="GI596_19315"
     CDS             10001..10150
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: thuricin"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GI596_RS19530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GI596_19315"
                     /product="hypothetical protein"
                     /protein_id="WP_002037542.1"
                     /sec_met_domain="thuricin (E-value: 2.4e-40, bitscore:
                     128.8, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVLNKQNVNIIPESEEVGGWVACVGACGTVCLASGGVGTEFAAA
                     SYFL"
     gene            10198..10341
                     /locus_tag="GI596_RS19535"
                     /old_locus_tag="GI596_19320"
     CDS             10198..10341
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GI596_RS19535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GI596_19320"
                     /product="hypothetical protein"
                     /protein_id="WP_002037543.1"
                     /transl_table=11
                     /translation="MEVMNNALITKVDEEIGGNAACVIGCIGSCVISEGIGSLVGTAFT
                     LG"
     CDS_motif       10198..10230
                     /prepeptide="leader"
                     /note="peptide class: sactipeptide"
                     /note="predicted sequence: MEVMNNALITK"
                     /locus_tag="GI596_RS19535_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       10231..10341
                     /prepeptide="core"
                     /locus_tag="GI596_RS19535_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="26.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="VDEEIGGNAACVIGCIGSCVISEGIGSLVGTAFTLG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MEVMNNALITK"
                     /leader_location="[10197:10230](+)"
     gene            10452..11972
                     /locus_tag="GI596_RS19540"
                     /old_locus_tag="GI596_19325"
     CDS             10452..11972
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Thuricin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="GI596_RS19540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19325"
                     /product="radical SAM protein"
                     /protein_id="WP_000039165.1"
                     /sec_met_domain="Thuricin_rSAM_RRE (E-value: 1.2e-40,
                     bitscore: 130.3, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 9.2e-44, bitscore:
                     142.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.4e-09, bitscore: 30.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.3e-16, bitscore: 54.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKKRLSMMPFKTDKFSYALDGNTGRVIVADKPTLYIISHFHKFE
                     KEELLKKTKGKFAELHQDYLTTYNYVSSLINMGMFYLSEKEDSDSPIDSKELAINSNQS
                     QLILILTEKCNLRCEYCIYNDKYPKEMGYSDEEMDFETAKKAVDMYYELHMERVKRGHK
                     RFPVITMYGGEPLLKFDLIKKVMEYAKGLMPDTLFYTTTNGTLLSEKMMDYFINNRIII
                     TFSIDGFKENHDRNRVFVNGMPTFERAFKNIKRLQEKKKEQNIEQIISFNCCFDQYTDV
                     YKVAKFFEEHYDLFNPFFVLYNQINPFDTLYFDWCDEQVKTGKWNFDKNNFKNAMQKIE
                     HELYEAETCDDHFQQVAGPLVMKDFVLSIRNKDGQQQITRNSCIPTSKIAVSPDGTLTL
                     CEKMCKKYPIGTVEKGLDWKAVDGVTEKLVRHFNSDSCKYCPIRTMCEACFMFLDENGR
                     IKPSFCKSKKMAVKKNLESYFAKKEKGFDVMKVYNHTSDLDSVKEMVK"
     aSDomain        10458..10709
                     /aSDomain="Thuricin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a thuricin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GI596_RS19540_Thuricin_rSAM_RRE.1"
                     /evalue="3.30E-41"
                     /identifier="RREFam020.1"
                     /label="GI596_RS19540"
                     /locus_tag="GI596_RS19540"
                     /protein_end="86"
                     /protein_start="2"
                     /score="130.3"
                     /tool="antismash"
                     /translation="KKRLSMMPFKTDKFSYALDGNTGRVIVADKPTLYIISHFHKFEKE
                     ELLKKTKGKFAELHQDYLTTYNYVSSLINMGMFYLSEKE"
     gene            11969..13213
                     /locus_tag="GI596_RS19545"
                     /old_locus_tag="GI596_19330"
     CDS             11969..13213
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="GI596_RS19545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19330"
                     /product="radical SAM protein"
                     /protein_id="WP_000759818.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.5e-31, bitscore:
                     102.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.2e-09, bitscore: 30.7,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.3e-11, bitscore: 36.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.2e-14, bitscore: 46.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.9e-07, bitscore: 24.3,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKYFRLYPYCHLEIGETNSCLYDISSGKMIRVNRENAELLRQCQ
                     ENVPIESINMDLGILDELIKMNLGTYYANPQFIEPFFETNDTKNRIFGKNNILRQMFIL
                     TSTDCNMNCKHCNTDSTVFRKTGCKIWPKSINLNALTQSHWRKILEAFYNLHGEELTFI
                     GGEPFLEFDFIKNIVEIAQEVGISKFSIFTNGSIINDTILNFLMENKIKVYIQIFEVDE
                     NKFKAFTNSDIPSIQIIDNIKKLNNHHLDLQLRILITRDNDNNVKKIVNTLQKETNVKD
                     IKIEFLYPKPDNSYYSKKYIPLMYDKKREFSHVNVQKMQFLHQYNPSFFGQITIRRDGK
                     VVPHPMLLTRVIGDLQQDDLFTIINTEEYQEYSTLNKEKISKCSTCAYKYNCMDDRVIE
                     NFATGDLYGMEYCNF"
     gene            13244..14437
                     /locus_tag="GI596_RS19550"
                     /old_locus_tag="GI596_19335"
     CDS             13244..14437
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015531.4"
                     /locus_tag="GI596_RS19550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19335"
                     /product="S41 family peptidase"
                     /protein_id="WP_001076214.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 6.5e-24, bitscore:
                     77.1, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQRNLFLAESLVRIVNENYLFTGNQKRRWDRLSPLYLRKIQDSK
                     VDSIIFDIIQDMVLELHDPHTLFFQRKEFRYCFDINVQWINNELFLIKNKNGYPEDYIG
                     SKILKINSFNIIDEFKKQQKKFVGFPASMIRKAIIQNIMEGKYGAEELTILVETIDKKR
                     KTFVINAQSIKHLFDYKSNINIIKNSFKPIVFETINKDTLLIKILTFKFLGMSELFVSS
                     LRLLKGFKNIIFDIRDNSGGYISEAKQILSFIISKDIQMDYKIIQHAEEEKKFKVSSIQ
                     VTSNQISLFSKRKFFILCNGGTASSAEFIFLKGLLLSNEDLTIIGEQTAGLSGQAKIFT
                     IDEKDIIQVTTKKFLSRQGKEIKEGIQPDYTVIPLICDIINNKDTLLNFCLERFKLI"
     gene            15049..15417
                     /locus_tag="GI596_RS19555"
                     /old_locus_tag="GI596_19345"
     CDS             15049..15417
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000791546.1"
                     /locus_tag="GI596_RS19555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19345"
                     /product="DUF3796 domain-containing protein"
                     /protein_id="WP_000791541.1"
                     /transl_table=11
                     /translation="MKNKLAYLGFIGFLGFLGLLGPHSFLGETSFTYYFFAFFPFFLYA
                     KVIPDELFILHVRIAATKAFFVALVMGVLLILSIVIFANVHVIRLCVVLAVVIPLGTFV
                     INLEIFERREKKGMQDAT"
     gene            15407..15607
                     /locus_tag="GI596_RS19560"
                     /old_locus_tag="GI596_19350"
     CDS             15407..15607
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016089760.1"
                     /locus_tag="GI596_RS19560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19350"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_001237537.1"
                     /transl_table=11
                     /translation="MRLKTRMKEYRVKLSMSQEDLANEVGVRRETIGNLENGKYNPSFK
                     LTYDIAKVLKAPIEVLFWFEE"
     gene            16032..16577
                     /locus_tag="GI596_RS19565"
                     /old_locus_tag="GI596_19355"
     CDS             16032..16577
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018980.1"
                     /locus_tag="GI596_RS19565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19355"
                     /product="hypothetical protein"
                     /protein_id="WP_001018982.1"
                     /transl_table=11
                     /translation="MAIVRQGEVLEVGKKISGNFKDGFKFNNGIANKHIIDPDVWSMNI
                     RDVEILTEEKSRSKKSVAGRAIVGGVLLGGVGAVVGGVTAKNKTKMYAAISYHNGMQDI
                     LEVSPFELNDLKRIAEQNREKGNTIYRDIEKDYSNYPPNQNVNKQESQSDTGSLLIEIF
                     SIVFWIVVLIMIIKWLFT"
     gene            16785..17384
                     /locus_tag="GI596_RS19570"
                     /old_locus_tag="GI596_19360"
     CDS             16785..17384
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017658211.1"
                     /locus_tag="GI596_RS19570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19360"
                     /product="hypothetical protein"
                     /protein_id="WP_049800275.1"
                     /transl_table=11
                     /translation="MKGEDNLEVYNSAAPAQTNNEELPFDISWMTDWIVDWFGSLFNGG
                     SDVIKDGGDKIDGAVHASVPAFFDVIFLILSVVILISLLVFGASLWFKHIKWKKRSIYF
                     GVGSFILILLIRILPVLMLTTRSFDFQTFMSNMVGLITSIILGTAVLMFLISLALGMLY
                     KKFEHPKYGKWSSSLRYSSIFIFVMTLLVPALLRHL"
     misc_feature    17525..17534
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.22"
                     /tool="antismash"
     gene            17543..17770
                     /locus_tag="GI596_RS19575"
                     /old_locus_tag="GI596_19365"
     CDS             17543..17770
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002162024.1"
                     /locus_tag="GI596_RS19575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19365"
                     /product="hypothetical protein"
                     /protein_id="WP_000206849.1"
                     /transl_table=11
                     /translation="MTTFVVMVSIFLILFVIGPKATKKKEERDRIKKEHEEKMEVLEEE
                     KIDLDINGTKVRLHKKPKLKKSIYRIKSNR"
     gene            17816..18265
                     /locus_tag="GI596_RS19580"
                     /old_locus_tag="GI596_19370"
     CDS             17816..18265
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000483321.1"
                     /locus_tag="GI596_RS19580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19370"
                     /product="hypothetical protein"
                     /protein_id="WP_000483321.1"
                     /transl_table=11
                     /translation="MFNRTKEVPKYQQIHSGLYKFELPYITGLFKSMEPNEDKVREVQR
                     FPVEVYVLNDKDIANDIEARFVMYGNDTRSVGDRYAQLATILRRAYFTALFIPDVPEKI
                     KWIEHRNAKNTVRNREEILEIELKWDEKSASYSIVGHSLLNSIFD"
     gene            complement(18349..18780)
                     /locus_tag="GI596_RS19585"
                     /old_locus_tag="GI596_19375"
     CDS             complement(18349..18780)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079847.1"
                     /locus_tag="GI596_RS19585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19375"
                     /product="hypothetical protein"
                     /protein_id="WP_001079847.1"
                     /transl_table=11
                     /translation="MNRIKVPFGRKKKPKLPVEDISALSSMEFDHLLHVLNEHANRYTY
                     YNRSYEIRKFQQLIAFHLANKLTKQQTFSNIELGILNVILENRNLPIEERKKSGDFVLL
                     EEIDKQNNSNEFINQLIENNFQLVENIAYVRLNDANEHN"
     gene            complement(18783..20393)
                     /gene="dnaX"
                     /locus_tag="GI596_RS19590"
                     /old_locus_tag="GI596_19380"
     CDS             complement(18783..20393)
                     /EC_number="2.7.7.7"
                     /GO_component="GO:0009360 - DNA polymerase III complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /gene="dnaX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074056.1"
                     /locus_tag="GI596_RS19590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19380"
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="WP_172795156.1"
                     /transl_table=11
                     /translation="MSNYVALYRAYRPNSFNDLVGQDHIKTTIMNAIKLEKVAHAYLLS
                     GPRGTGKTTVAKIIGKGVNCLAPLSNGEPCQKCANCSDINNNKFADILEFDAASNNGVE
                     EIRQIRDQVHLAPVTGKYKVYIIDEVHMLSNSAFNALLKTLEEPPAHVIFILATTDPQK
                     VTKTIISRCQQFEFRNIPLQAMIDRLKFISHDQGIRITDEALHLISQLAEGGLRNALSI
                     MDQVIAYATNNVTIEHVATVVGKVAIQDIEKLIHYITEKDLTSTLDSLQTILERKQADF
                     FLSDLIGYYRDLMIFNLSQKTDMFKVAIYNNAFINLAERIPLSKIPSILEELTTVQYKI
                     KSSVYAATLIEIALVKILQLEQEISTIQPNIKNNENEDSSELNQTLLQSLLDTIAAFNQ
                     RLDEFEKQKEEPTANQRRRNIQIYRDPKAKETAKDIVLPEITWETSKLLETFLPNCIAH
                     IKKDNPLIANSLGEIVHATGSKHHIIFVMENPQQVETLYNPLNDSIVTKTISQLLRRQI
                     KMIYLEKSEWEEINTNKEV"
     gene            20687..21970
                     /locus_tag="GI596_RS19595"
                     /old_locus_tag="GI596_19385"
     CDS             20687..21970
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000504300.1"
                     /locus_tag="GI596_RS19595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GI596_19385"
                     /product="DUF2325 domain-containing protein"
                     /protein_id="WP_000504300.1"
                     /transl_table=11
                     /translation="MGELVSITKKDGKESIDLFKHYSECFEEGDSIGQDKISDELFTKV
                     KDAVTQYWLESMDSLPDVVDLYIIISLIESDSPKHKKIVTRFFNDCKIFLTAKEKKQGK
                     RGKIDRLLKEYSKPQMKERLQKNLKVAGEIEIAQLQAAYDQTVNQQKKIKDVQEVIEKY
                     GMHFTIFITAYIKTQGTDDMHDLYLEAAPFRYINILAELAIFHQERYPSQEKAEEISFK
                     EEWNKLQSKLNEYEKKLNKQEKMLNKYKMENEYLKKQKISSDAKASRVVKQTERSVNEL
                     MTELATEEEIKSEQHKKEIEYLNKMIEQMAQEIIQLQKEEEPEGDVHKNDLSGKKVAVI
                     GGNKERYYRECVEKYNAEIIFVAEDQHRKIDSAVKKADVVFYLTELLSHIYHELIIPAA
                     ARYNTPIRFVNSKGISAFESALNRYANE"
     misc_feature    22062..22073
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
ORIGIN
        1 gctaaatttg gatatattgc aaaaaccagt atgtccgaca aagctattac aaaagctaaa
       61 agacaactaa aagaacgaat caaaagaatt caaaaggagc ccacttcaga gaaagttact
      121 caatttaatt caacccttct tggtatacaa aattacttta aatatgcggt tacaatttac
      181 atggatttaa cggaggtaaa ttactctctg cgaagagtca taagaaccag acttagaaac
      241 aatatgaagc acatgaagtt ctgtgaaaca tctgtgaatt ttaaaaggaa gaccaaagga
      301 atacaaccta acactaagat ttacgttgta cagaacactc cactcttacc agttacagga
      361 atacatcata aaaacccgtg gaatttttcg caggttatct gtaactatac ggaaacgggg
      421 cgtaataaag tacatagtaa tcttaaggca atacctaagg atgttctcaa ccaagttatg
      481 aggacttatt cgaagaataa aagtattgag tacaacgata ataggatatc aaaatacgtt
      541 gctcaatatg gtaagtgtta tgtaactggt gaggaaattg gtattgaacg tgttcattgt
      601 catcacattg ttcccattaa acaaggtggg gatgacaagt acaacaactt ggtaattgta
      661 gattggttta tacacaaact gattcacatg acgaatctta ataagattac acattacctt
      721 cggtctttta aacttaacaa gaaacaaatg gataaactga atgtgctaag aactaaagct
      781 ggaaatgaac cgatagtaac ataatttgat tttaaagtca gttggaaacg atggaacgcc
      841 gtatgctagg aaactagcac gtacggtgtg aggtggggga aaaggtggag attacatcaa
      901 agccttacct atcatcatag agggggaact ggacagaaga tttacacggc ttagaaggta
      961 aggtaaatgt aattacacta ggtactgata gacgagatga agggaagcta gacccattta
     1021 tcatccataa acatagcaga aaagatgcaa ttgagttagc aatgacaatt cttactttca
     1081 ttacaggtat taaacctgat aactcagaaa aattcccgcg tttggcttcg gctgtagaat
     1141 ttgttgcagg gatggaagaa ccgtgcttaa cagctgtatc tcaatacctt gaagatagtg
     1201 aggataaagt ggatcaacaa ttagctgctc atattcaagc ttttgagaat ttatcctttg
     1261 cacacttaat ctttggtgat ggaacaaata gagatattga acttgataca gcagtgaata
     1321 tcatacaaat tcagcatctt gatatgccag atattcaaaa agatccaaaa gattatacct
     1381 tacaagaaaa tttatcagtt agtatgctga tgtctctatc ttcttttgca agaaaattct
     1441 ttcaaaagga tcctactaaa ttcaaaattg ttctattaga tgaagcatgg gcaatcatgg
     1501 gaacttctca aggacgagag ctagctcgta agctagttcg tgaaggtcgt gccttaaact
     1561 cagctgtata ctttgctact caaagtgcaa gtgaccttgg agatgagaca tttaagaata
     1621 atatcggtat gaagttctca ttccgtaaca cagacagtaa agaaatttct tcaatcttag
     1681 atttctttgg attacctgat aatgaggaaa atcatgcgat tgttactaat ttagaaacag
     1741 ggcaatgctt attccaagat atccaaggaa gaacaggtgt tgtcacaatg gatgtagtgt
     1801 ttaaggattt atacgatgca ttcgatacaa gaccaaatgc aagaaagaat tatagaaagt
     1861 caaatgatga tgaaaagcag gaagttaatg caacctttgt cgaagaaggg ggagaaaaaa
     1921 taaatgtagg agtgagttaa catggtaaaa actaaactaa aaaaattaat gctatctagc
     1981 ctatgtgctg gcgctctaat tctgagcgcg gcatgtggaa atagcgaaac aaatgtagga
     2041 gaagaaaaag ataaacaggg gcacactcca agagaaatga tgcttgattt tgtaaaggcc
     2101 gacttacaac atgattataa aacaatacgt aaattagttg tcgatgggga gaaaaataaa
     2161 atattggacc ctaataaagg acctcaaaat aatttatctt acaaagatta cactgtaaaa
     2221 gaatatgtgg tagataagga tacaattatg tataacttta tttcaaagaa gccccctaag
     2281 aatatcgata aagcagtgaa atggataaga gtagttcgta cagacgatgg gttcaaagtt
     2341 cgaagttata ccggccctga acgaaatgaa attgatgaag tagcaaatac taaaccgaca
     2401 aatgaattta gttccaaaga ttaatggttt tcccataaaa gggggagtaa catgtaatga
     2461 aaaagtttat taccctattg ttattaattt gtactttgct tttagcattt aatttacttt
     2521 ttaaagctgc tccagtatat gcagaggaag aacccagacc ttctcttata gacgatatca
     2581 ttccaaagaa taaggaaaaa ttaaaatatg aagaatatcc accaagtagt tatggcatcg
     2641 atgtttatac tccagaaggt ggatttggag aatctcttaa attctggaaa tggaaagata
     2701 atattaaaga acaaattgta gcaactattt ttatattaat tagtattggg tggtcagtaa
     2761 accttgcaat tagtagtttt gtgactagta tggtaggcca atcaatgagt ttaaatatag
     2821 tagctgatgt tggagataag ctaggtgatg taatctctaa agcggcaggc ttcaatggtt
     2881 cttggggtaa tggaatatat agtgaattaa ttggactcat gttagcttta ttagcttgct
     2941 gggttatctg ggtaggcttt gtacaacgac gccagtcaga gatgctagga ggattgttaa
     3001 agacattagg tattttagtt ttcactttag cttttttcgc aaattcaagt tatattatca
     3061 aaggactgaa cactttctct gaacaagtaa ataaaactgt tcttgattcc actcaaagta
     3121 ttagtggagc aagtgaagga tattcaagtg gtgtcgattc tatcactgat ttaacgcata
     3181 ctctattaat caaacaacct tatacgttat tacagtttgg tacaacagat atgaagaaaa
     3241 ttggtgatga gagaattaag aaaatgttaa caacgacaga tcctgatgaa agaaaagctc
     3301 ttttaaagga tgaagttgag gttcagaaaa accaaacact ctcgttagat gctacttttg
     3361 aaagaggggc acttgtatta ttacttggag caattaatct acctttatgg atcgttcttg
     3421 gattatgcag tatggcgatg ttattctatc aattaatgtt tattattgta gctttaatgt
     3481 cacctgtaat gttattaatg gcattagttc cagcctggac tgggacagct aagaaatttt
     3541 tatctgaatt gttccgaacg ctgcttatga aagtagcaat aggctttctg gtaactttaa
     3601 tgttttgggt atcgtcaatc ctatttagcg ctactgataa atatggatat ttagttgtag
     3661 ctgcattaca agtactttca ttcttaggtg tttggttata ccgtaaaaca attttcgatg
     3721 ctattactac agtaccagca agtgccggag ctgcacgtgc atcagatgct atgagtaata
     3781 ttaggcagaa atatcgtgat gttagacgtg gatctaagac agttggaaga ggtgtagcag
     3841 tagctggcgc cgcgggtctt gcaagtgctg cggtggcagg aaaagtgggg aaatcaggct
     3901 acagtaagtt taaacagttg aaagaaaact atgcagatag aaaagaaaag gtagcagatg
     3961 gtaaacgcaa ggaaaaagaa caaatgcaag cagaaaaaga aaaaaatata aatcaaatga
     4021 aaaaagaaga aaatttaggt gttcgcgata gaaagggaaa tcaggagcaa gaaagggtta
     4081 aggaagaagt agccgcaaca aaagagaatc cggaattagc agtacgaggg caacatcaag
     4141 ataataatcc tgaaatgcaa caggcagaac taaaagataa agaagaggat gtaaaagcgg
     4201 atgtccaacc agtagcgcaa tcaaacgatg aactaaataa taaagaagaa gatgtaaaag
     4261 ctcaagttag gccagtggca aatcaaaata gcagtggact tgagaataag caagaggatg
     4321 taaaggcgga agcaaaacca ggagcaacaa ttaaaacacc aacgggtcaa acaaagccaa
     4381 ttacaacacc actgtcagga acaacaccat tacaatcgag tccgatggaa agtaaaccaa
     4441 ttacaacacc acaatcagga acaacaccat tacaatcgag tccgatggaa agcaaaccaa
     4501 ttacaacacc acaatcagga ccaacaccat tacaatcgaa tccgatggaa agcaaaccaa
     4561 ttacaacacc acagtcggga ccaacaccat tacaatcgaa tccgatggaa agcaaaccaa
     4621 ttacaacacc acagtcggga ccaacaccat cgccagcgaa tccggtggag agcaagccaa
     4681 ttacaacacc acagtcggga ccaacaccat cgtcagcgaa tccaattgag agcaagccaa
     4741 tcacaacacc acagtcggga ccaacaccat cgccagcgaa tccggtggag agcaagccaa
     4801 tcacaacacc acagtcagaa ccaacaccag cgaatccgat ggaaagtaaa ccagttacta
     4861 cttcacatgt aagtacgcca caaaaacaag tagaggtaaa atcagttaat caacaacaaa
     4921 ctaaaagtgt tcctaaagta aataatcagc aacaggtaaa agaaggggca gcaattaaaa
     4981 aagttgaaac gaaagcacaa acgcaacaag aagctttaaa aaatgtaaaa gcaaaagaaa
     5041 cgataaaacc aaaataattc agctcgtgag ggagggttta tacattgagt gcggaaccaa
     5101 atcgcgactt tgaaaatgaa catcatcctg aagctgaact agggaatgct aagcctgcct
     5161 tgaaaaaggc aggccattct ttaggaaagg cggctggaaa aggatccaaa atagcgggta
     5221 aagcagttgc acaagttagt aagaaagtag cggttaaggt agctcaaaag gcagctacag
     5281 ttgctgttgc aaagccatta ttaataatag ctggtgttat tctggctgtt gttgcaggtt
     5341 taggaatagt catattttta ttaactgcta caatgggaga ggatgaagtc agtcccgggg
     5401 gaattggtgg tccttttaca ccaggtactg caagtgttag ccctgaagta atgagatggg
     5461 agccattggt gagaaagtat gcagcacaac atggaattga agcaatgact ccattaatac
     5521 tagctcttat tcaacaagaa agttctggga ctcaattgga tgtaatgcaa agttcggaat
     5581 cacaaggata tggtccagga tattttacag atccagaaga aagtattaaa tatggtttaa
     5641 tgcattttgc tgattgtcat aaaaaatcca acggcgatcc aaatattaca ctacagtgtt
     5701 ataattatgg tactggttat gcaaactatg cactttctaa cggtggatat acacatgcga
     5761 atgcaagagc attttcagca gaacagacag caaaaactgg ttataaatgt gcttcttggc
     5821 gaagtgcaga agcagtagcc aataattggt gttatggtga tccagactat gttccgcatg
     5881 tactaagata ttatcaaggt ggtagtggtg gtggaccagt agccggcgga gatgaattat
     5941 ttaaaaaggt aatggatgaa gccattaaat atcaggggtg gccttacgtt tggggaggaa
     6001 gaacaccaca atcatcattt gattgtagtg gactcattca gtgggtatat gggcaagcag
     6061 gtattaattt agtcggtact gcagaaacac aatttaaaat gacacagcga accaatgatc
     6121 cacaaccagg tgatttaata tttttccaag gtacgtataa accaggtatt tcacatattg
     6181 gaatttatgt tggtaacaat cgtatgttcc atgcaggaga tccaattggt tatgcagatt
     6241 taaatacacc gtattggcaa cagcattttg cgggttatgg taaggtggca agataggagg
     6301 ggtgaaatga aaaaaacgac aattttatta atcgtattgc ttataggtag cataggatta
     6361 aattttaaaa taaatgcaga taatgcccaa cttaaagatg aaaaggcaaa gctgtctaag
     6421 aaaatacaaa aagtagaatc acaatataaa gatacggaga aagaattgca agctttaaag
     6481 agtaataacc aacaacaggt aaaggaagca gctgagagat ttttgaaagc atttcgaaca
     6541 tatgatactg gtaaaggaga atcatatatt acaaacgttg aagcgtatat aactccaaat
     6601 gcgaagaagg aattgacacc tcctggtgca ccaaatccac ctgcttcaag tactgcagag
     6661 gaaaaagata agaaaaagtt agcttttaaa tcagagtaca ttggtggcga attatactat
     6721 gctttcatag atactaccaa agcaaacgta cttgctaagg ttaaaagtaa aatgattatc
     6781 aatggtgtat cgtctgaaaa tatgtcattg atgcaaatca atttaattta tgatggaaat
     6841 aagaagttat ggctcgttga caaggttata ccattagctg atttaagaga tcagatgcca
     6901 taagctaata aataaatact ataaagggtg taataataaa agagcctctt ctattattct
     6961 tggatagaaa gggctctttt gcttttagta gttattatta atatttaaaa atttagtgta
     7021 atgatgactt ttcccgttta tttctcatat aaacagcaat ttacatcatc tcttgctttg
     7081 ttagtatacc actccatcct aatcaccgag tttgataccc ttggaaaaga gcttgtatct
     7141 tagagataaa gggattgttg ttacttatta ttatggacag tgatttagag aaataagcgt
     7201 actcggtgat taggaataag aaagtattta agatatttga gatttcggta attgaataaa
     7261 taaaaaatac gctgttattt ttggtgtaga gagataggag aaattaataa ttatttaatc
     7321 taaaatataa tgttatttat gggaggacat tatttcttga ggtgaaaatt ataaagtcac
     7381 aggtaggtct ttgtaataaa gtatactttt aaatttggtt acatccttgt taattaaacc
     7441 agtacaatcg ttcatcatct accttttttt ataaaaacat tgaggatgag aagtttaggt
     7501 attatatatt aaagaataaa gcagatgttt atagatgttt aaaaacgttc tttttaaaag
     7561 gacgtttaat atgagtgtac ttgcagaaca aaaccttact atgtaataag agggaaatta
     7621 aaatcggtat aagcattcta ttttgatgaa aaatgtaaga tgtatttaaa tgtataaaca
     7681 ctgtaatgga atttatgcgc tgactgtata ttttatctaa atcttcatct taatatgttt
     7741 taggtcaact gatcttagtc tgcatttata agtatttgca ttccgtaatt agttatatta
     7801 ccatatattt aagagatatt ctatatatta ggaagaaggt attaatatga aagggaaaat
     7861 aaataaaatt acccaaagtt tgcaattgga aatattcaaa atgctaacaa attctccttc
     7921 ccttagactt attttacggg gagctggagt tacatttgta attatttttg gaacagcttt
     7981 aacaaagcaa ccgactgtat tctcaataaa ttttgtaatg ataatcttag gattcttttt
     8041 aatttttatg ccatatattt ttaggaatta taaaaaactt aattagccca aataacaccc
     8101 aatactagga agtagaaatt ttaaaaaaca ttgttatgat tgttcaatta taacaatgtt
     8161 tttttatttg gttaaaacat ctaaaattat acaaattctc cctatttatg tgttattaaa
     8221 tatatatatt tttataatca gggatatgat aataattatt ctgaaatatc aacattttgt
     8281 gaatgtattg aaaattttgt tttgtggtct tataataaaa gtacgttaaa gaaaataata
     8341 aattatagaa aaaagcttgt tattaaaggg ttctagataa catccttaga gttcgattaa
     8401 taattaatga ggtgtaattt atggacaaaa tattaaatgt aaaaggttta tcaaaaaaat
     8461 ataatgattt tcatttacat cacattaact ttgaattaaa acggggatca ataacgggat
     8521 tcatcggtga gaatggggca ggaaaatcta ctactattca atcaatacta aatatcatag
     8581 attatgattc aggtgaaata ctatttaatg gagaatcttt tcaacagaat agaaatgatt
     8641 taaaaaaaag aatcggatat gtaggagata acaataaatt ttatgatgac gtcaaattga
     8701 aagtaatacg taactttgtc aaggatgctt atttagaata ttgggatgat aaattttctg
     8761 aatatctagt taaggatgtg tttaacctta atcttaatat gaaaataaag gaattatcaa
     8821 aaggtatgag agcaaaattt ttacttactt tagctatgtc acataaccca gatttattaa
     8881 tactagacga accaacttca ggtctagatc ctattgtaag aaatcagcta cttgaaatct
     8941 taaatgatat tgcagaaaaa aagggaacta caattttttt ctcctcccat attactgatg
     9001 acattgaaaa aatagcacaa aaaatcattt atcttgataa tggttcgatt ttattggatg
     9061 aagaaaaggc ggctattttt aataggttta aaaaaatacc tatcgataaa atcaattcaa
     9121 tccaaattga aaaattaaaa gaaatcggag ttttagtaca agatcatata gttgtagaca
     9181 aacaggtatt aaaggaacag gatatatatg atcttaatct tgaaaaggtg gttttagacg
     9241 aagtgcttct actattaaag aaacaaaaaa tgaattagtt gtatagtgta atcaacttta
     9301 acttgattgg atgagtgatt attatgtttg caattttaaa aaaagatata ttaattaatc
     9361 aaaaatattt actaattgta ttactttatt caattatatt tcctgtcatt ttgataattg
     9421 atggagataa taaatattta atgatgagtt tcttattacc attcattaat gtgaatttct
     9481 ttgtaggaaa gtcttgttac atagaagatt cagtagatgt aagaaacttt ttgaagatgc
     9541 tacctattaa tcataataaa attgttttca ttagatatat tgaaatgatt gtaaccttgg
     9601 ctctttcgag cgtatatgca tttcttgttc aattatactt aatgaatggt gtaagtaatg
     9661 ctttcttaat acatgtaaat ctgttagttt tttcagcgct tttaatttac tttggtattt
     9721 atttatctgt gtattacaaa ataaattatc atgctgctca gaatacactt atgtttttat
     9781 ttgtaatagg agtctcaact tttatcttaa cagaaaaagt ttttaatata aaaatagaaa
     9841 tgattaatca ccttaactat agtgcatctt acattgcatt tgtaatctca ataattgtac
     9901 tttctattac gtatttatat tccattaagg aatttaaatt caataaattt gcttaaaaca
     9961 ttttgaagaa gaggatctta aaaataagga ggaattaatc atggaagttt taaacaaaca
    10021 aaatgtaaat attattccag aatctgaaga agtaggtgga tgggtagcat gtgttggagc
    10081 atgtggtaca gtatgtcttg ctagtggtgg tgttggaaca gagtttgcag ctgcatctta
    10141 tttcctataa gaattaaata aacataaaat gattaaaaaa ataaggagga attaatcatg
    10201 gaagttatga acaatgcttt aattacaaaa gtagatgagg agattggagg aaacgctgct
    10261 tgtgtaattg gttgtattgg cagttgcgta attagtgaag gaattggttc acttgtagga
    10321 acagcattta ctttaggtta aaaatatata tttacacaga atagcacaaa aacatttagt
    10381 aaacctcttc ttctaaatgt ttttttataa attcaaattt ttagtccatt attaatggga
    10441 gtgaatagaa aatgtctaaa aaaagactat caatgatgcc ctttaaaact gataaatttt
    10501 catatgcatt agatggtaat acgggtaggg taattgtagc tgataaacct acactgtaca
    10561 tcatctcaca ttttcataag tttgaaaagg aagaattatt aaaaaaaaca aaaggaaaat
    10621 ttgctgaatt acatcaagat tatcttacta catataatta tgtttcaagt ctcattaata
    10681 tgggaatgtt ttatttatca gaaaaagaag attctgattc accgattgat tcaaaggaac
    10741 ttgctataaa tagtaatcaa tcacagctta tattaatact tactgagaag tgtaatttac
    10801 gttgtgaata ttgtatttat aacgacaaat atcctaaaga aatgggatat tctgatgaag
    10861 aaatggattt tgaaactgct aagaaagctg tggatatgta ttatgaattg catatggaga
    10921 gagtaaaaag aggtcataaa agatttccgg taattacaat gtatggtggt gaaccattat
    10981 taaaatttga tttgataaaa aaggtaatgg agtatgcaaa aggacttatg cctgatactc
    11041 ttttttatac aactacgaat ggcaccttat tatctgaaaa aatgatggat tattttatta
    11101 ataatagaat tattattact tttagtattg atggttttaa agagaatcat gatcgaaaca
    11161 gagtattcgt caatggaatg cccacatttg aacgagcatt taagaacatt aaaaggcttc
    11221 aagaaaagaa aaaggaacaa aatatagagc aaattattag ttttaattgt tgttttgatc
    11281 aatatacgga tgtatataaa gtagcaaaat ttttcgagga acactatgat ttatttaatc
    11341 ctttctttgt tctttataat caaattaacc catttgacac attatatttt gattggtgcg
    11401 atgaacaagt taaaactgga aaatggaatt ttgataaaaa taatttcaag aatgctatgc
    11461 agaaaattga acatgaatta tatgaagctg aaacttgtga tgatcatttt caacaagtag
    11521 ctggcccgct agtaatgaaa gattttgttc tttcaataag aaataaggat ggtcaacaac
    11581 aaattaccag aaatagttgt attcctacta gtaaaatagc tgtttctcct gatggtactc
    11641 taacattgtg tgaaaaaatg tgtaaaaagt atccaatagg cactgttgaa aaaggcttag
    11701 attggaaagc tgtagatggc gttactgaaa aattagttcg gcattttaat agtgactcat
    11761 gtaaatactg tccgattaga acaatgtgtg aagcgtgctt tatgttcctg gatgaaaatg
    11821 gtcgaattaa gccttcattt tgcaaatcta agaagatggc agtaaagaaa aatttagaaa
    11881 gttattttgc aaaaaaagaa aaaggctttg atgtaatgaa ggtttacaat catactagtg
    11941 atcttgattc tgtcaaggag atggtaaaat gaaaaaatat ttcagattgt atccatattg
    12001 tcacttagag ataggggaaa caaattcatg tctatatgat atcagtagcg gtaaaatgat
    12061 aagagtaaac agagaaaatg ctgagttatt aagacaatgt caagagaatg tacctattga
    12121 atccattaat atggatttgg gtattttaga tgagttaata aaaatgaatt taggtacgta
    12181 ttatgctaat ccacaattca ttgagccttt ttttgaaact aacgatacga aaaacagaat
    12241 attcggtaag aataatatat taagacaaat gttcatttta acttccacag attgtaacat
    12301 gaattgtaag cactgtaata cggattcaac tgtttttaga aaaacagggt gtaagatttg
    12361 gccaaaaagt attaatttaa atgcattaac ccaatcgcac tggagaaaaa ttttagaagc
    12421 attttataat ctacatggag aagagctaac atttattggt ggggaaccat ttttagaatt
    12481 tgattttatt aaaaatattg tagaaattgc ccaggaagtt ggcatttcaa aattttctat
    12541 attcactaat ggtagcatta tcaatgatac tatacttaat ttcttgatgg aaaataaaat
    12601 aaaagtgtac atacaaatct ttgaagtaga tgaaaataaa tttaaagcat ttactaattc
    12661 agatatccct tccatacaaa ttatagataa tataaaaaaa ttaaacaacc atcacctaga
    12721 tctgcaactt agaatattga tcacaaggga taatgacaat aatgttaaaa agatagttaa
    12781 tacacttcaa aaagaaacta atgttaaaga tattaaaatt gagtttctat atccaaaacc
    12841 agataatagt tattattcta aaaagtatat tcctttaatg tatgataaaa aaagagagtt
    12901 ttcacatgtt aatgtgcaaa aaatgcaatt tttacatcag tataatccaa gtttttttgg
    12961 ccaaataacg ataagaaggg atggcaaagt agtaccacat cctatgttgt taactagggt
    13021 tataggtgat ctccagcaag atgatttatt tacaatcatt aatactgaag aatatcaaga
    13081 gtacagtact ctcaataaag agaaaatatc caaatgttca acatgcgcat acaagtataa
    13141 ttgtatggat gaccgagtaa ttgaaaattt tgctaccggt gatttgtatg gaatggaata
    13201 ttgtaacttt taagttaaat ccaatatttt aggagtattc aatatgaatc aaaggaattt
    13261 atttttagct gaaagtttgg ttcgaattgt taacgaaaat tatttattta caggcaatca
    13321 aaaacggaga tgggacagac ttagtcctct ttatctaaga aaaatccaag attctaaagt
    13381 agattctata atttttgata ttattcaaga catggtttta gaattacatg atccacatac
    13441 tttatttttt caacggaaag aatttcgtta ttgctttgat attaatgtac agtggattaa
    13501 taatgagtta tttctaataa aaaataaaaa tggatatcct gaagattata taggtagtaa
    13561 gatattaaaa ataaattctt ttaatataat agatgagttt aaaaagcagc aaaagaaatt
    13621 tgtaggcttt cctgcaagta tgataaggaa agccattata caaaatataa tggaaggaaa
    13681 atatggagct gaagaattaa cgatacttgt tgaaacaatt gataaaaaaa gaaaaacatt
    13741 cgtgatcaac gcacaatcta taaaacattt atttgattat aaaagtaata ttaatataat
    13801 taaaaatagc tttaaaccga ttgtttttga aactataaac aaagatacgc tgttaataaa
    13861 aattttaact tttaagtttc ttggtatgag cgaattattc gtctctagtt taagattact
    13921 gaaaggattt aaaaatatta tttttgatat tagggataat tcaggaggat atatttcaga
    13981 agcaaaacaa atattatcct ttattatttc taaggatatt caaatggact ataaaataat
    14041 acagcatgct gaagaggaaa agaaatttaa agtttcttca attcaagtca ctagcaatca
    14101 aatttcactt ttttcaaaac gaaaattctt cattttatgt aatggtggta cagcaagttc
    14161 ggccgagttc atatttctaa aaggattgct gctatctaat gaagatttaa ccattatcgg
    14221 agaacaaaca gctggtttat caggacaagc aaagatattt actattgacg aaaaagatat
    14281 tattcaagtc acaacaaaga aatttcttag taggcaggga aaagaaataa aagagggaat
    14341 acagcctgat tatacagtta ttcctttaat atgtgatatt attaataata aagatacact
    14401 tttgaacttt tgtcttgaaa gatttaaatt aatttaataa tgtaagaatg ggtatataat
    14461 aaaattagtg ttaaaaagat aaaggtattc acaaacataa atcttcttaa aaatttacgt
    14521 ttgtgaatac ctttttatga taaataagtg ttaatttaaa gatactttct gaatattact
    14581 acaggttctt ttggaaaatg aatagtgtct tttatagatg ttttatgaat tttccctcta
    14641 atatgttacc ttttcaagaa cagatttgag aagacaattt ttcttttcga tatcttcagt
    14701 cgcatagtat gcttccaata tattttttat tctgggaaca aactgatgta tgtgcttttc
    14761 tctttctaat acatccttaa tttcatgctc aagttgttca atttcttctt gggtagtttt
    14821 taaacgtatt acaatggact tttgtcgttc taaaaaagtt ccaatatcgt atacaccctt
    14881 ctctaataaa tcatggagtt tatgtaggtt tgcaataaag tttaaccgtt ttgaaaaaag
    14941 attaactgct tataaaaaag tcgtaccgtt ttcaatcctt tttatttcca agttaatatg
    15001 atatatttat aacaattagt gcgaaataca tcacaaagga gaattcacat gaaaaacaaa
    15061 ctggcttact tggggtttat tggatttcta ggatttctag gacttttagg tcctcattca
    15121 tttttaggtg aaacatcatt tacatattac tttttcgctt tcttcccctt ctttttatat
    15181 gcaaaagtta taccagatga actttttatc ctgcatgttc gcattgctgc cacaaaggca
    15241 tttttcgtgg cattagtaat gggtgtttta ctaatcttaa gtatcgttat ttttgcaaat
    15301 gtacatgtaa tcagattatg cgttgtactt gcagttgtaa taccattagg aacttttgta
    15361 attaatttag aaatatttga acgtagagaa aagaaaggga tgcaagatgc gacttaaaac
    15421 tcgaatgaaa gaatataggg taaagctaag tatgtctcaa gaagatctag ccaatgaggt
    15481 tggtgtccga agggaaacaa ttggcaatct cgaaaatgga aaatataatc cttcattcaa
    15541 actcacttat gatattgcga aggttttgaa agcacctatt gaagttctgt tttggtttga
    15601 agaataggtt aggtaaaaat atattgttgt aatagatatg tctatgagtt ttgattaatc
    15661 ttttttataa aaactagatt cggatttcta acaaaagact ccattttgat tattcttttt
    15721 tcaaaatgga gtcttcttat ttaccatata atatgggttt gtggagtttt tttgattaaa
    15781 ctttatttca aatcaacaca aagtaacgct aatgattgta gaaaactcac ttgtatagac
    15841 aagaaatggt gatttgtgta aaatttagta tatgaatcaa agcatataaa gaatttaaca
    15901 attttggaag agaataattt tttactataa catctattaa tttgattaaa aaaataaata
    15961 aaataaaaga ttttataaaa atagttatat atctttaagt ataatttgaa aaaatatagg
    16021 agtgttactt aatggcaatt gttcgacaag gtgaagtttt agaggtagga aagaaaataa
    16081 gtggtaattt taaagatggt tttaaattta ataatggcat cgccaataaa catattattg
    16141 atccagatgt atggagtatg aatataagag atgtagagat tttaacagag gaaaaatcta
    16201 gaagtaaaaa aagtgtggca ggaagagcta ttgtaggggg agttctgctg ggaggagtag
    16261 gggctgttgt aggtggagtg acggcgaaaa ataagactaa aatgtatgct gcaatttctt
    16321 atcataatgg aatgcaggat attttagaag tatctccatt tgaattaaat gatttaaaga
    16381 gaatagctga acaaaataga gaaaaaggca atacaatcta tcgtgatatt gagaaagatt
    16441 attcaaacta tccaccaaat caaaatgtaa ataaacaaga atctcaaagt gataccggtt
    16501 cacttctcat tgaaatcttt agtattgtgt tttggatagt tgtattaatt atgattatta
    16561 aatggctttt tacttaatca atctaagttt taaagttata tagataaccc cgtcctaaat
    16621 tatgggcggg gttatgttta tttaatgatt gtataatcgt taatttagca ttgcataaaa
    16681 cactaacaat ttttaatttg ataatattat ctcttctcaa atttagccaa tttcttagtt
    16741 ttaataagaa aatttatata cttaaagtaa agggcttaat ttcaattaag ggggaggata
    16801 atttggaggt gtataactca gctgctcctg cacaaacaaa taatgaagag ttaccattcg
    16861 atatttcttg gatgaccgat tggattgtag actggtttgg ttctttgttt aatggtggca
    16921 gtgatgtaat aaaagatggg ggagataaaa tagatggtgc agtccatgcg agtgtgcctg
    16981 cattctttga tgttattttc cttatacttt ctgtagtaat tttaatatca ttattagttt
    17041 ttggggcttc tttatggttt aaacatataa agtggaaaaa aagatctata tattttggag
    17101 taggttcatt tatcctcata cttttaataa ggattctacc agtgttaatg ttgacaacac
    17161 gttcatttga ttttcaaacc tttatgagta atatggtggg cttaattact tctataattt
    17221 taggaacagc tgtattaatg tttttgatat ctttagcatt aggtatgctt tataagaaat
    17281 ttgaacatcc caaatatgga aaatggagtt caagtttgag atatagttcc atttttatat
    17341 ttgtaatgac cttgctggta ccggccttac tgcgtcattt ataatttcgt tttataaaag
    17401 gagaaggagg aatagtgcaa attatttcta taatatttct gtgtaatgat gctagtgctt
    17461 attctcctgt cgatttcaag attaaatctt attgattaaa aaatatatgg tacgaagttt
    17521 tggcgaaggg ggagaggtac tagtgacaac ttttgttgta atggtaagca tattcttaat
    17581 tctgttcgta attggtccaa aagcgactaa gaaaaaagaa gaaagagata gaattaaaaa
    17641 ggaacatgaa gagaaaatgg aggttttaga ggaagaaaaa attgacttag atattaatgg
    17701 aactaaagta cggttacaca agaagcctaa gctaaagaaa agtatatata gaataaagag
    17761 taatcggtag caaaaattaa atcgagttat attcatatac taagggggat tactaatgtt
    17821 taatagaacc aaagaagtac caaaatatca acaaatacat tctggattat ataagtttga
    17881 attaccgtat attactggtc tatttaaatc catggaaccg aatgaagata aggtacgtga
    17941 ggtacaacga tttcctgtag aagtgtatgt tcttaatgat aaagatatag caaacgatat
    18001 agaagcaaga tttgtgatgt atgggaatga tactcgatca gtaggagatc gttatgctca
    18061 gttagcaaca atactaagga gagcttactt tacagcatta tttattccag atgtaccaga
    18121 aaaaataaaa tggattgaac atcgtaatgc taaaaataca gtacggaata gagaagaaat
    18181 attagaaatt gaattaaaat gggatgaaaa atcggcatct tatagtattg taggacatag
    18241 cttactcaat agtatctttg attgaggtat cattaatcct attgttcatt tgatttcaaa
    18301 tgtttaaccc cgcctatatt taagcggggt tattttttaa tggattattt aattatgttc
    18361 attagcgtca tttaatcgta cgtatgcaat gttctcaact aattgaaagt tattttctat
    18421 tagttggtta ataaattcat ttgaattatt ttgcttatca atttcctcta ataatacaaa
    18481 atcacctgat ttttttcttt cctcaattgg taggttccta ttttcaagta taacgtttag
    18541 gatacctaat tcgatgttag aaaatgtttg ctgctttgtt aatttatttg ctagatgaaa
    18601 tgcaattaat tgttggaact ttctaatttc ataagagcga ttataatacg tatatctatt
    18661 tgcatgttcg ttaagtacat gcaatagatg atcaaattcc atagaagata aggcggaaat
    18721 atcttcaact gggagtttag gtttcttttt tcttccgaat ggtactttga tacgattcat
    18781 ttttacactt ccttattagt atttatctct tcccactcac ttttttctaa gtaaatcatt
    18841 ttaatttgac gtctaagtaa ttgtgaaatg gttttagtaa ctatggaatc atttaatgga
    18901 ttatataaag tctcaacttg ttggggattt tccattacga atataatatg gtgctttgat
    18961 ccagtggcat gaactatttc tcctaaacta tttgcaataa ggggattatc tttctttata
    19021 tgagcgatac agttgggtag gaatgtttct aataatttgc ttgtttccca agtgatttct
    19081 ggtaaaacaa tatcttttgc agtttcctta gctttagggt cgcgataaat ttgaatgttt
    19141 ctgcgtcttt gattagcagt tggttcttct ttttgttttt caaattcgtc taaacgctga
    19201 ttgaatgctg cgatggtatc aagtaaactt tgtaacaatg tttgattaag ctcactggaa
    19261 tcttcatttt cattattttt gatattcggt tggatcgttg atatttcctg ctccagctga
    19321 agtatcttaa ctaatgcaat ttcaattagt gtcgctgcat atacagagct ttttatttta
    19381 tactgtaccg ttgtaagctc ttcaagaata cttggaatct tggataatgg tattcgctca
    19441 gcaagattta taaaggcatt attataaatg gccactttaa acatgtcagt tttttgagat
    19501 agattgaata tcatgaggtc tctgtagtaa ccaattaaat cgcttaaaaa gaaatccgct
    19561 tgttttctct ctaggatagt ttgcaaggaa tccaaagtgc tggttaaatc tttctcagtt
    19621 atataatgta ttagtttttc aatatcctga attgctacct taccaacgac tgttgcaaca
    19681 tgctctattg ttacattatt tgttgcgtat gcgatgactt ggtccattat gctaagagca
    19741 tttcttaaac cgccttcagc taattgggat attaaatgta atgcttcgtc tgtaatacga
    19801 atcccttgat catgggaaat gaattttaac ctgtcaatca ttgcttgaag aggtatattt
    19861 cgaaattcga attgttggca tctagaaatg atagttttag taactttttg tggatctgtt
    19921 gtagccagta tgaaaataac gtgtgctggt ggctcttcta atgtctttaa tagagcatta
    19981 aatgccgaat ttgaaagcat atgcacttca tcgataatat acactttata tttccctgta
    20041 accggtgcta aatgtacctg atctcgtatc tgccgtattt cttctactcc attattgctt
    20101 gcagcatcaa attctagaat gtccgcgaat ttattattat tgatatcact acagttggcg
    20161 cacttttgac aaggctcacc attacttaat ggagctaagc agttaacacc ttttcctatt
    20221 attttggcaa cagttgtttt accagtacct cgtggtccag agagtaggta ggcatgggct
    20281 actttttcta gtttaatcgc attcatgatg gtcgttttaa tatgatcttg ccccactaaa
    20341 tcattaaagc tatttggtct atacgcacgg tatagtgcaa cataattact cattaatatt
    20401 cctcccataa atatcaaatt ttattaaatg gcaatccttt taaatgcaaa aaagcagcca
    20461 aatgagtaga gttactgttc acattttcat gtgttaactc aacccaaagg gctgctttta
    20521 atttaaagaa gaaaaaacaa aaagtaaaaa attataagaa tattataact cttgaactaa
    20581 caaaaaggaa gattaaaaac tttattaatc gatttgacac tcgtaattcc acatattact
    20641 atttagagga gttatcagaa aattctattg tgagagggga ttaaaaatgg gtgaattagt
    20701 ttcgattaca aaaaaggacg gaaaagaatc aatagattta tttaaacatt atagtgagtg
    20761 ttttgaggaa ggagattcta taggtcaaga taagatatct gatgaattat ttacaaaagt
    20821 gaaagatgct gttactcagt attggttaga atctatggac tcattacctg atgttgttga
    20881 tttgtacatt attatttctt taatagaaag tgattcaccg aaacacaaga aaatagttac
    20941 tcgttttttc aatgactgta aaattttctt aacagcgaag gaaaagaaac agggtaaacg
    21001 agggaaaatc gatcgcttgt taaaagaata tagtaaacca cagatgaaag aaaggcttca
    21061 aaagaattta aaagtcgctg gtgaaattga gatagctcaa ttacaagcag cgtatgatca
    21121 aacagttaat caacagaaga aaattaaaga tgtacaagaa gtaattgaga agtacggaat
    21181 gcatttcaca atttttatca ctgcttatat aaaaactcaa ggaacagatg atatgcatga
    21241 tttgtactta gaagctgctc cattcagata cattaacatt cttgcagaat tagcaatatt
    21301 tcatcaggag agatatccta gtcaagaaaa ggctgaagag atttcattta aagaggagtg
    21361 gaataaactt caaagtaagt taaacgagta tgaaaaaaag cttaataaac aagaaaaaat
    21421 gttaaataaa tacaaaatgg aaaatgaata tttgaaaaaa caaaaaatct catcagatgc
    21481 taaggcatca agagttgtta agcaaacaga gaggtcagta aatgaattga tgactgagtt
    21541 ggcaactgag gaggaaatca agtccgaaca acataaaaaa gaaatagagt atttaaataa
    21601 aatgattgaa caaatggctc aagaaatcat tcaattgcag aaagaagaag agccggaagg
    21661 agatgtgcat aagaatgatt tgtcaggaaa gaaagtggct gtaattggtg ggaataaaga
    21721 aagatactat agagagtgcg ttgaaaagta caatgcagaa attatatttg tagcagaaga
    21781 tcagcatcgt aagatagata gtgcagttaa aaaagctgat gtagtctttt atctaacaga
    21841 attattgagt catatatatc atgagttaat tattccagcc gcagctcgtt ataacactcc
    21901 tatccgattt gtaaatagta aggggatttc agcgtttgaa agtgccttga atagatatgc
    21961 aaatgagtaa aatgtaaagt gaaccgtata tttaagtatg atataatact tgtgatatat
    22021 ttttgaattt tctttcgttt attaggaatt atgcccttcg ggtaaaagaa cgctgtacat
    22081 cgtacatgca attcttttcc ggagggctat ttttatttgt acaaaagtat gaaagagagg
    22141 ggaaagtttt gaagatgtca gaaaaacaaa gtgtatttct accagaaggc tactttgaaa
    22201 tgaagacgat acctcaagcg gaaatagctg atatttacac ttctaaggaa ttaataactg
    22261 ataatggatt tgattcattt tattttagag cgttagaaga aaatggcatt tatctaaacg
    22321 agaaacaaat tgaagctgtt cgaacaattg atagacctgt attagcaatt gctgctgcag
    22381 ggagtggaaa gacaagagtt ctagcaagta gagtaggcta cttaatgtgt gtagcacatg
    22441 tagatgcatc aagaatatta gttttaacat tcacacgtaa agcggccaat gaaatgaagg
    22501 aaaggattgc tggtttacca ggcataagta aatcggtatt aaatactatt gttgctggta
    22561 catttcattc tgtatttttg aggatattaa gaagcagagg atacgatcaa cgtattttaa
    22621 gtaatgaaaa gttcaaacac atcattatta aaaacatatt aaagaaatat aaataccagg
    22681 aagcatatga ccctgaaact atattgtcac ttatctctta ttacaaaaac acttttgtaa
    22741 ctccaaagaa tcttcctgct aaaacgccaa ttgaaaagga aatcaagaca atatatcaat
    22801 cttatgaaga atggaaagca gataataatc aaatggattt tgatgatatc ttactatata
    22861 cctatgaact tcttttagat gactatcatc ttcttgaatt acttcaaaat aagtttcttc
    22921 atatcctagt ggacgaatat caggatatta gcttgctgca acaaatgata gttaagatgt
    22981 tagcataccc gcaaaaatta atattcggtg tgggggacga tggtcaaact gtatattcgt
    23041 ttaggggttc caatccaaaa ttgatattag attttccgaa tgaatttcca ggtacgaaag
    23101 tgataaagct tgaggtcaat tatagatcaa atccatatat tgttggactt gggaatgaag
    23161 taataaaaaa caataagata caatttaaaa aagaacttag agcctataaa gtg
//
