LOCUS       NZ_CP047883            24045 bp    DNA     circular CON 27-JUL-2024
DEFINITION  Streptococcus mitis strain S022-V3-A4 chromosome, complete genome.
ACCESSION   NZ_CP047883
VERSION     NZ_CP047883.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus mitis
  ORGANISM  Streptococcus mitis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2086958)
  AUTHORS   Pinzauti,D., Iannelli,F., Pozzi,G. and Santoro,F.
  TITLE     Complete genome sequence of the tetracycline resistane Streptococcus
            mitis isolate S022-V3-A4
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2086958)
  AUTHORS   Pinzauti,D., Iannelli,F. and Santoro,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-JAN-2020) Department of Medical Biotechnologies,
            University of Siena, Viale Bracci, 16, V lotto, I piano, Siena, SI
            53100, Italy
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-NOV-2018
            Assembly Method                   :: Unicycler v. NOV-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013305725.1-RS_2024_07_27
            Annotation Date                   :: 07/27/2024 01:18:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,027
            CDSs (total)                      :: 1,952
            Genes (coding)                    :: 1,893
            CDSs (with protein)               :: 1,893
            Genes (RNA)                       :: 75
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 24 of 59
            Pseudo Genes (incomplete)         :: 39 of 59
            Pseudo Genes (internal stop)      :: 19 of 59
            Pseudo Genes (multiple problems)  :: 16 of 59
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:35:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1109342
            Orig. end                         :: 1133387
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047883.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Francesco Santoro.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24045
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RaS-RiPP"
                     /product="sactipeptide"
                     /region_number="4"
                     /rules="(PF04055 and TIGR01716)"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /tool="antismash"
     cand_cluster    1..24045
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /kind="chemical_hybrid"
                     /product="RaS-RiPP"
                     /product="sactipeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..24045
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14045]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14045
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     gene            477..>578
                     /locus_tag="M594_RS05520"
                     /old_locus_tag="M594_05540"
                     /pseudo=""
     CDS             477..>578
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851913.1"
                     /locus_tag="M594_RS05520"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05540"
                     /product="XRE family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIGDHIKSLRKTHDMTQLEFARIGDISRNSLSCY"
     gene            627..1453
                     /locus_tag="M594_RS05525"
                     /old_locus_tag="M594_05545"
                     /pseudo=""
     CDS             627..1453
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /locus_tag="M594_RS05525"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="M594_05545"
                     /product="IS630 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAYSIDFRKKVLGHCERTGSITEASHVFQISRNTIS"
     misc_feature    665..680
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 19.74"
                     /tool="antismash"
     gene            1685..3817
                     /locus_tag="M594_RS05530"
                     /old_locus_tag="M594_05550"
     CDS             1685..3817
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024565.4"
                     /locus_tag="M594_RS05530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05550"
                     /product="AAA family ATPase"
                     /protein_id="WP_173876181.1"
                     /transl_table=11
                     /translation="MIISTLKKLTIKSFDNYDIPDDFFKRKNLVFGHNGRGKSSLARAI
                     IDEYRSFPETSSDGYRFFNRDYVRDKLLLTDSNNELKGVKAFFGEKDTDIQNKIIKLES
                     EIVDTIQLKMSIKEDSDTVRQKINDIHDSKKGKARISKKNSSFTLRQVISSYENDLEDA
                     KKVNPNLTNIKDFSGDSESLEKELERVQNIVLPNLEIKALSSEDLEFLDTCLSKNYKLE
                     DIPSFKIVNWIEEGLSIHHQDEHECLFCHSQLNIEEIKLRVEKYKRNQVQKDTQRLSLI
                     LEKLKNNLSLFNEAKNSTNSLRILEVSEEEIHNYYTIESEQGLIEIINIIITKLSDMNN
                     THSVNLDSIKKFENQVNKLDLNLKNLRSSKLNRINSDLSNIETLTKGAIYLAIKDTDIL
                     QSINSIENSEKELISIERSNNIKRLEIENLNKSLSEYSDFAEFLNEVLKDLGIQFSLQL
                     HGKNYYLQHNFHDVVLSINDISEGEKNLLALLFFYFELYSDKEQLQIKETIELIVVDDP
                     ISSLDESNRFYVLEIIKRIFEEDQPQVFIFTHSWNDFSSLGYRLNDENVYSLFEVYKKE
                     TSEVRKIHENLPPYKLLFKEIIEVSRKNYSEELTEAERYHTANSMRRVFEEFLYFKKPN
                     LLPQRSNHSAIEEFYMKATGEPLSNNYRRKLGELLSFINVLSHTPYRSDAVIANAKFLM
                     NLIQKLDKVHYDSMIS"
     protocluster    2690..24045
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12689:14045](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12690..14045
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="2"
     gene            3866..4153
                     /locus_tag="M594_RS05535"
                     /old_locus_tag="M594_05555"
     CDS             3866..4153
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000423011.1"
                     /locus_tag="M594_RS05535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05555"
                     /product="hypothetical protein"
                     /protein_id="WP_173876182.1"
                     /transl_table=11
                     /translation="MKLQEVRNMLGNDFEAIISEFEREGIVFESQFSSLYSMFCKKYTY
                     QLVKLLEKETQLEVSYGYAVPYFYYFDTNRFDRSEATRIAIKYQIDKGNM"
     misc_feature    4329..4342
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.02"
                     /tool="antismash"
     gene            4336..5019
                     /locus_tag="M594_RS05540"
                     /old_locus_tag="M594_05560"
     CDS             4336..5019
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000492697.1"
                     /locus_tag="M594_RS05540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05560"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_173876183.1"
                     /transl_table=11
                     /translation="MFSPTKLKEKRESQGLSQSQLASSLGISRASYFNWESGKTKPNQN
                     NLSKLSQILTVDPCYFESEYEIVETYLKLTEKNQKATLHYATELLNKQNAKVVDIPERF
                     AYKVYEKLSAGTGTAYFDDGNYDTVYFNHQFDYDFASWVFGNSMEPTYENGSVALIKQT
                     GFDYDGAIYAIDWDGQTYIKKVYREENGLRLVSLNRNYSDKFAPYDENPRIIGKIVGNF
                     MPLED"
     gene            5022..6437
                     /locus_tag="M594_RS05545"
                     /old_locus_tag="M594_05565"
     CDS             5022..6437
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149971.1"
                     /locus_tag="M594_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05565"
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_173876184.1"
                     /transl_table=11
                     /translation="MTWFDYSLEPKSDIAFIDMKSFYASVECVDRGLHPLKTSLCVMSR
                     ADNSAGLILASSPMFKKVFGKSNVRRSYDLPFDVKTRKFSYYNARKQGLPTTIDYVRYI
                     EDWAKSTVIVPPRMDTYIAVNMEIQKIFQDFAAPDDIYPYSIDEGFIDLTSSLNYFVPD
                     KSISRKDKLDIISAAIQKKIWRKTGIYSTVGMSNANPLLAKLALDNEAKKTPTMRANWS
                     YEDVEKKVWSIPKMTDFWGIGNRMEKRLHSLGIFSIKELAQANPDLIKKELGIMGLELW
                     FHANGIDESNVHKPYKPKSKGIGNSQVLPRDYVKPRDIEIILREMAEQVAVRLRRAGKK
                     ATVVSIHLGYSKVEQKRSIHTQMKIEPTNQTALLTNYVLKLFHTKYTSGAIRSVAVSYS
                     GLVDDSFGLISLFDDVEKIEKEERLQSAIDAIRTEFGFTSLLKGNALDQASRTIARSKL
                     IGGHSAGGLDGLK"
     gene            6434..6799
                     /locus_tag="M594_RS05550"
                     /old_locus_tag="M594_05570"
     CDS             6434..6799
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000981955.1"
                     /locus_tag="M594_RS05550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05570"
                     /product="hypothetical protein"
                     /protein_id="WP_049539642.1"
                     /transl_table=11
                     /translation="MMNRSYLPFLSAREYQDRGMAKWMGFFLSEHSSSLWEEKNREDIS
                     ISLSMEEKVLFVRQLYTNVFPATFVCKLSNRRKVVSGIVKEIGRESISIKSDSGFLRLR
                     WEDILDIQIEGVDLYES"
     gene            6789..7079
                     /locus_tag="M594_RS05555"
                     /old_locus_tag="M594_05575"
     CDS             6789..7079
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001080188.1"
                     /locus_tag="M594_RS05555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05575"
                     /product="DUF5960 family protein"
                     /protein_id="WP_001080184.1"
                     /transl_table=11
                     /translation="MNRKELYDDKLQLDYFSDSYLQFESDFYKYSALDIPLTFITDDIL
                     RTMAMSQKHYFKLNKSKSLDGRDHYFVFSIKMNKDSSGIRQYEYQRHCFNL"
     misc_feature    7255..7269
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.31"
                     /tool="antismash"
     misc_feature    7270..7285
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.03"
                     /tool="antismash"
     gene            7374..7733
                     /locus_tag="M594_RS05560"
                     /old_locus_tag="M594_05580"
     CDS             7374..7733
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003085008.1"
                     /locus_tag="M594_RS05560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05580"
                     /product="SAG1252 family conjugative relaxosome accessory
                     protein"
                     /protein_id="WP_048787830.1"
                     /transl_table=11
                     /translation="MGQEIKSIRKQFRITRQEEKQIKEMMREQKVDSFSEFLRQNLLKK
                     NYQDRIFESWFSLWQSQKFEQISRDVYEVLVVARENHQVTQEHVSILLTCVQELIAEVN
                     QVQPLSREFREKYMG"
     gene            7743..8108
                     /locus_tag="M594_RS05565"
                     /old_locus_tag="M594_05585"
     CDS             7743..8108
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000263054.1"
                     /locus_tag="M594_RS05565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05585"
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="WP_173876185.1"
                     /transl_table=11
                     /translation="MVYRYRTNLKKVFLTDPELHQLNERIAKSNCQNFSVYARKVLLNP
                     NMAFVTINTDTYEQLVFELRRIGNNINQIARAINQSHLISQDQLQELSKGVGELIKEVD
                     KEFQVEVKRLKEFHGSY"
     gene            8095..9957
                     /locus_tag="M594_RS05570"
                     /old_locus_tag="M594_05590"
     CDS             8095..9957
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260374.1"
                     /locus_tag="M594_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05590"
                     /product="SAG1250 family conjugative relaxase"
                     /protein_id="WP_173876186.1"
                     /transl_table=11
                     /translation="MVVTKHFATHGKKYRRRLIKYILNPDKTDDLKLVSDFGMSNYLDF
                     PSHAEMVEMYNVNFINNDKLYESRNDRQEKHQQTIHAHHLIQSFSPEDNLTPEEINRIG
                     YETMMELTGGRFKFIVATHTDKDHVHNHILINSIDRNSDKKLIWNYALERNLRMISDRI
                     SKVAGAKIIEKRYSYRDYKKYRESSHKFELKQRLYFLLQQSKSFDDFLEKAKQLHVQID
                     FSQKHSRFMMTDRAMTKPIRGRQLSKRDLYDEEFFRTHFTKQEIESRLEFLLNRVNSLE
                     DLITKAKELNLTIDLKQKNVTFILEEDNQKISLGHQKISDKKLYDVKFFQDYFKNKEVI
                     ASEGLENLQEQYHAFQEERDKDKVSTEEIEEAFETFKEKRDTVREFEVELAENQIEKLV
                     DEGIYIKVSFGIKQSGLIFIPNYQLDILEEENQTKYKIFIRETTSYFVYNKEHSDKNQY
                     VKGRTLIRQLTNDGRVIPYRRPTVKSLQEKITEINLFIELTEADKKYQDIKDELVKEIA
                     EIDIKLNQINEKIANLNKMAEVLINLKSEDVSSRKLARYDFSKLNLPESITVEQVSEEI
                     RAFQEELDHYLYEYESLIKNLEMFVKVLNDKDFDKKFSIEILLE"
     gene            complement(10001..10849)
                     /locus_tag="M594_RS05575"
                     /old_locus_tag="M594_05595"
     CDS             complement(10001..10849)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837481.1"
                     /locus_tag="M594_RS05575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05595"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_173876187.1"
                     /sec_met_domain="TIGR01716 (E-value: 4.7e-50, bitscore:
                     167.1, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSKLGITLRKIRKGKKISLSSIADSNLSKSQISRFERGESEISC
                     IRLINILDKLHITLDEFIILHDNNSTKTGSFANLVQYIRKHYSSKNFASIIELLSNSSS
                     FNLGPYEKTMVKSILYTTNKNFLPSDEELLQLTDYLFKVENWGYYEIILLGNCVRTINY
                     NSYFLLTIEMLKNYLYSTLNKTNKRLVTQLAINCLIVSIDKEEFQNCSFLIKEIKKLLN
                     NELNYYEQTVFLYTCGYFEFKCNPVNGIEKMKQALQVFEILGEHNIKAQYQEHYDKYIN
                     Q"
     gene            11063..>11288
                     /locus_tag="M594_RS10120"
                     /pseudo=""
     CDS             11063..>11288
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864824.1"
                     /locus_tag="M594_RS10120"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="recombinase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIKAGYLVRLRDIEDT"
     gene            11493..12350
                     /locus_tag="M594_RS05580"
                     /old_locus_tag="M594_05600"
     CDS             11493..12350
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01716.1"
                     /locus_tag="M594_RS05580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05600"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_173876188.1"
                     /sec_met_domain="TIGR01716 (E-value: 6.4e-41, bitscore:
                     137.2, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLGQILKKIREAKGLSLYNIANDEISTSQLSRFENGYTDITLS
                     KLLSVLKTLDVSLEEFMYLGRGFHKMSNFEVIDKINNYFYKNNSPALRRLLINCIEKEE
                     EKLSKKLTIILIKLKLQEIEKDNIVTSEEIDFISDYLFSIDIWGEYELELFSSTMEIFC
                     QSSIMILTKEMVRRTDFYKHLPTHRRLITSMLFNAFSLSVERNNIVDASYYREQLVQLF
                     FDETELYERLVFHLIDSCYNFKMTNELSNILEMRKCIGFLKTLESMSLVDKWEKYIERV
                     LNSN"
     gene            12448..12618
                     /locus_tag="M594_RS05585"
                     /old_locus_tag="M594_05605"
     CDS             12448..12618
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004633836.1"
                     /locus_tag="M594_RS05585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05605"
                     /product="subtilosin A family bacteriocin"
                     /protein_id="WP_302478521.1"
                     /transl_table=11
                     /translation="MTKNNKIDNPSVKIEKATVVNNKGCSVCAIGAVCLADGPIPDFEI
                     AGVSAVFTAFG"
     CDS_motif       12448..12489
                     /prepeptide="leader"
                     /note="peptide class: sactipeptide"
                     /note="predicted sequence: MTKNNKIDNPSVKI"
                     /locus_tag="M594_RS05585_sactipeptide"
                     /aSTool="sactipeptides"
                     /tool="antismash"
     CDS_motif       12490..12618
                     /prepeptide="core"
                     /locus_tag="M594_RS05585_sactipeptide"
                     /peptide="sactipeptide"
                     /predicted_class
                     /score="26.00"
                     /molecular_weight="0.0"
                     /monoisotopic_mass="0.0"
                     /core_sequence="EKATVVNNKGCSVCAIGAVCLADGPIPDFEIAGVSAVFTAFG"
                     /aSTool="sactipeptides"
                     /tool="antismash"
                     /leader_sequence="MTKNNKIDNPSVKI"
                     /leader_location="[12447:12489](+)"
     aSDomain        12690..12959
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M594_RS05590_Subtilosin_rSAM_RRE.1"
                     /evalue="3.00E-21"
                     /identifier="RREFam018.1"
                     /label="M594_RS05590"
                     /locus_tag="M594_RS05590"
                     /protein_end="90"
                     /protein_start="0"
                     /score="66.6"
                     /tool="antismash"
                     /translation="MYLVLDNQVTIYQTKGDYNVIVEKIDANKRKQFDYFTVNKTGKLL
                     LEAINGKQNMEEFIENFIDTYNLVEDDRNWIETFLNEMMKKGAIA"
     gene            12690..14045
                     /locus_tag="M594_RS05590"
                     /old_locus_tag="M594_05610"
     CDS             12690..14045
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: subtilosin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.4"
                     /locus_tag="M594_RS05590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05610"
                     /product="radical SAM protein"
                     /protein_id="WP_173876189.1"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 2.1e-19,
                     bitscore: 66.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="subtilosin (E-value: 2.6e-96, bitscore:
                     319.5, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.7e-07, bitscore: 27.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.6e-35, bitscore:
                     119.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.3e-16, bitscore: 57.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1e-06, bitscore: 25.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.6e-08, bitscore: 31.1,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.5e-07, bitscore: 27.5,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYLVLDNQVTIYQTKGDYNVIVEKIDANKRKQFDYFTVNKTGKLL
                     LEAINGKQNMEEFIENFIDTYNLVEDDRNWIETFLNEMMKKGAIAIKESPEIANLPLYI
                     YGNSRLISPLHVTVEITEKCNLYCAHCYLNASCNKTTAIDYEGFKSLVKKLKASNVLSI
                     EITGGEVFMNKDAEKILELAFNEFSRVALLTNGTILKKSSLSLLEKNKDKLVMSISLDS
                     VREELHDKFRGMRGSFRSTCKNIKRLTEAGIHVRVASSIFDENMWEVDKLAELAIELGA
                     ELFVYNFVENFGRGTDFNKNSSTKFSKEYSRYLSETVFKYRALIPIIESEDYLKSSSNC
                     GAGTNTILIGADGNLRPCPIFPKNKIFKNINDGSMEEIFSDDVYQKISNIYPPSDENGC
                     SKSCPNYSNCFGCYMKGLESNVDKAPEQYCSWITYNKLEKFMEQYKGGKVIE"
     gene            14038..14958
                     /locus_tag="M594_RS05595"
                     /old_locus_tag="M594_05615"
     CDS             14038..14958
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M594_RS05595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M594_05615"
                     /product="hypothetical protein"
                     /protein_id="WP_173876190.1"
                     /transl_table=11
                     /translation="MSNYLFSYKYYRPIPNLFIKQKLREIHKLLKEDLIKFGIENGIII
                     SIFALGCNGRMTEIIYIKSMYRISEDKIYDMLDFLYNKEIELYKVVKDDNINCTISCYG
                     VTANASIPTKESLGYFLKNFLKWENYSVKKYSRVKLETTENIIIKEGELTYVGFLCDNI
                     EIKELGDMLSAKLLEEIFKSQNSVLTEIRNQGLCYTTVSKFHEDLNVVYIGLITSYSED
                     KISRLDTMYTNVQLTEGEFELAKCRLKKEIIFSTTLYQIDHYLLPFQLLKIDANVSTLL
                     EIIDKIKFEDIVKIFNSRRIVCLKA"
     gene            14973..15821
                     /locus_tag="M594_RS05600"
                     /old_locus_tag="M594_05620"
     CDS             14973..15821
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M594_RS05600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M594_05620"
                     /product="hypothetical protein"
                     /protein_id="WP_173876191.1"
                     /transl_table=11
                     /translation="MEKDCTFFIKPVSDLGEVTIERIIFNFNGSIREGYLHLLEHLWVR
                     ANKSWFDDYESKMNIFNALTDKNRITFILIYTESTVNTNKLIFDLNFNEQDFLIEKKTI
                     YEERKLYSDSTPDVDIVLGSLRTIEAFDLIVLKNMMHQMNYKKIRFHFSSKNNGKYMKN
                     PTINIKKNSIIWKDSNTIQLKDFYDYKVLLTILKVFKLTNESFCFNINEAKENYEITFD
                     DYEVFDFMLKNKDNVLKRYQLLLTNTQLFIEQTIYLFDLFGFNLDILDFWREFNWEVLE
                     K"
     gene            16475..16612
                     /locus_tag="M594_RS05605"
     CDS             16475..16612
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003001697.1"
                     /locus_tag="M594_RS05605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_173876192.1"
                     /transl_table=11
                     /translation="MNKKLRLAIAICFFVGAFMFVFMKEFLYAVAFMIVGGVYLYKGVR
                     "
     gene            16614..17306
                     /locus_tag="M594_RS05610"
                     /old_locus_tag="M594_05625"
     CDS             16614..17306
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903664.1"
                     /locus_tag="M594_RS05610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05625"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_173876193.1"
                     /transl_table=11
                     /translation="MTTLLELKKLNFAYVKNSKILDNIDLILNQNKVYGLIGKNGAGKT
                     TFIKILSSVFNNNVFTLEYFKFFDKEVQLSSEFYRQNKYTVFTESESFLNWTFLQYLEM
                     VCQLYNCSIERKRLEFLVNGFKFEEYCQKEIRDLSTGNKKKVFLIVGLYLRRPLLILDE
                     PFDGLDFESTEFLYKMLLEYKQYGTVLLSTHFAESVVRVCDYLYILENAHINLFQGNVS
                     EWLESIRK"
     gene            18822..19043
                     /locus_tag="M594_RS05615"
                     /old_locus_tag="M594_05630"
     CDS             18822..19043
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000285460.1"
                     /locus_tag="M594_RS05615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05630"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_173876194.1"
                     /transl_table=11
                     /translation="MYRRLRDLREDHDLTQKQIAEILSFTNSAYAKIERGEHALTADVL
                     VTLSNFYDVSTDYLLGLTDFPDKIRFRK"
     gene            19348..19581
                     /locus_tag="M594_RS05620"
                     /old_locus_tag="M594_05635"
     CDS             19348..19581
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000693750.1"
                     /locus_tag="M594_RS05620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05635"
                     /product="hypothetical protein"
                     /protein_id="WP_001022845.1"
                     /transl_table=11
                     /translation="MNIKYISVENSIAEWADKKGILKRWDGLNQYTLNRWIKEMRENRT
                     FSMYVINPTHKLVFINLEGFESFLRWKQKRTK"
     gene            19666..21174
                     /locus_tag="M594_RS05625"
                     /old_locus_tag="M594_05640"
     CDS             19666..21174
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000291919.1"
                     /locus_tag="M594_RS05625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05640"
                     /product="site-specific integrase"
                     /protein_id="WP_024057448.1"
                     /transl_table=11
                     /translation="MYYVTKTNSKGQPLYQVVEKYKDPLTGKWKSVTVSYTKNTSRARK
                     QAEREVLDKIDRLTTSFESQYSPELITTFGELKENWFQTWCVSVKPQTIQRELLVMKRL
                     GKIIGDDFLLDRITPLLMKNSLNKYLEMYDASPSTMTHIKSTCNKIFNHGVLYNVIKFS
                     PMTAVKLDISLEKRRKAKERHDSKFLEIHELHAFFDVLRQCRNANYYDLAIVLLLTGIR
                     ISEAAFLPSDIDFEKGILHIDKALQYHCLKVKQFHFDTTKTLNSIREVALPEAASEAIK
                     RTIQRNKDFDAYMKKHPCPAFTHSESVFRTEYGSPITSSTFRQILKRIEGKLLTNCLSD
                     YGFKWVKHVTPHSFRHMHISYLQSNEMHIAVKDIMTRVGHANFETTMGYTHNINRSQEN
                     TVKALNQFVENHNFHFEELKSYTCKYSRMIEKFIETSDNSNKVELSVDEFKDLLHLSPR
                     YSPKNIVSNLLLKIKKDIVKYHPQFDIKIVKSSENQIRGFSIAW"
     gene            21256..22107
                     /gene="ylqF"
                     /locus_tag="M594_RS05630"
                     /old_locus_tag="M594_05645"
     CDS             21256..22107
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ylqF"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201313.1"
                     /locus_tag="M594_RS05630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05645"
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="WP_173876195.1"
                     /transl_table=11
                     /translation="MATIQWFPGHMSKARRQVQENLKFVDFVTILVDARLPLSSQNPML
                     TKIVGDKPKLLILNKADLADPAMTKEWRQYFESQGIQTLAINSKEQVTVKVVTDAAKKL
                     MADKIARQKERGIKIETLRTMIIGIPNAGKSTLMNRLAGKKIAVVGNKPGVTKGQQWLK
                     TNKDLEILDTPGILWPKFEDETVALKLALTGAIKDQLLPMDEVTIFGLNYFKEHYPEKL
                     AERFKQMKIEEEAPVIIMDMTRALGFRDDYDRFYSLFVKEVRDGKLGNYTLDTLDDLDG
                     DD"
     gene            22094..22873
                     /locus_tag="M594_RS05635"
                     /old_locus_tag="M594_05650"
     CDS             22094..22873
                     /EC_number="3.1.26.4"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004523 - RNA-DNA hybrid ribonuclease
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201102.1"
                     /locus_tag="M594_RS05635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_05650"
                     /product="ribonuclease HII"
                     /protein_id="WP_173876196.1"
                     /transl_table=11
                     /translation="MATIKEIKELLATVKDLDNPIFLELEKDNRSGVQKEIIKRKKAIQ
                     AELEEDLRLESMLSYEKELYKQGLTLIAGVDEVGRGPLAGPVVAAAVILPKSCKIRGLN
                     DSKKIPKKKHLEIFQAIQNQALSIGIGIMDNQVIDQVNIYEATKLAMQEAISQLSPQPE
                     HLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELMKEYDQQFPGYDFAANA
                     GYGTAKHLEGLKKLGVTTIHRTSFEPIKSLVSGEKES"
     misc_feature    23198..23217
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 20.28"
                     /tool="antismash"
     misc_feature    23213..23227
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.06"
                     /tool="antismash"
     misc_feature    23889..23903
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.79"
                     /tool="antismash"
ORIGIN
        1 gatagctaat acatgcagca agatttatta cgctattctg ttcttggtta tatgaatcaa
       61 gaattttatt taacttctga tagatttcac cttcaaattt attaatttta tacactgact
      121 tctcctatcg ataacaattt attatcatta gtataccata aattcatctt tagtagattg
      181 atttgtataa tgattttttt agtaaaaatt aaatagcaaa ctatgatatt ggtcaacgag
      241 agcttaaaac acgattttta aatcatatct aatacttttg atttaattac aaacttgaaa
      301 caatggggga ttagtatagg ttgaaggaaa taagtacaaa tttattagaa aatcaagatt
      361 gcatagaatt agcacgaaaa atttcaattt tagaactata gccccaaatg attttgaatc
      421 agtcttttta attttctaaa tgatatgata gtattatcaa gtaaaaagaa atttccctga
      481 ttggagacca tatcaaatct ttacgaaaga cacatgacat gacacaacta gaatttgcac
      541 gaattgggga tatttcacgt aatagcctta gttgttacta tagtgaaatg aaccaaaaat
      601 agtacataat gtggtataat cttcttatgg catattcaat agattttcgt aaaaaagttc
      661 tcggtcattg tgagcgaaca ggtagtataa cagaagcatc acatgttttc caaatctcac
      721 gtaataccat tagttaaaag agaaaatagg agagctaaac catcaagtaa aaggaacaaa
      781 accaagaaag gttgatagag atagacttaa aaactatctt actgataatc cagacgctta
      841 tctgactgaa atagctgctg aatttagctg tcatccaact gctattcact atgctctcaa
      901 agctatgggc tacactcgaa aaaaaagaac cacacctact atgaacaaga cccagaaaaa
      961 gtagctttat ttcttaagaa ttttaatagt ttaaagcact tagcacctgt ttatattgat
     1021 gaaacaggat tcgatactta tttttatcga gaatatggtc gctcattgaa aggtcagtta
     1081 tctggaagaa aatatcagag gatttctttg gttgcagggc taacaaatgg tgagttaatc
     1141 gctccaatga cttacgaaga gacaatgacg agcgactttt ttgaaacttg atttcagaag
     1201 tttctcttgc taacattaaa tacaccctca gttattatta tggataatgc aagattccat
     1261 agaatgggta agctagagct tttatgtgaa gaatttggac ataaactttt actccttcct
     1321 ccctactccc tactcacctg actacaatcc tattgagaaa acatgggctc atatcaaaaa
     1381 gcacctcaaa aaggtattac caagttgtaa tacttttttc gaggctcttt tgtcttattc
     1441 ttgtttcaat tgactataac agtatcaact aaggatagcg ttaccgttgt tccacttcca
     1501 aaagtggaaa gcatagatga ctgtatcgat aaagccaagt ctcaacttaa gacggataaa
     1561 ttagagaaac ggatagagga gtttaagaag aggaggaagt aaggctagca gaattttatt
     1621 gataatataa atgtttctat tcatatgaaa tatggtacaa taaaattgta atggaggttt
     1681 agcaatgata atttcaactc ttaagaaact gacgataaag tcgtttgata attatgatat
     1741 tcccgatgat ttttttaaac gaaaaaattt agtatttggt cacaatggta gaggaaagag
     1801 ttcactagcc agagcgatta ttgatgaata taggtctttt ccagagacgt cttcagatgg
     1861 ataccgtttt tttaatagag actatgtacg ggataagctc ttattgacag actcaaacaa
     1921 tgaattaaag ggcgtaaagg ctttttttgg tgaaaaagac actgatattc aaaataagat
     1981 tattaaacta gaatctgaaa tcgtagatac gattcagctt aaaatgtcaa ttaaggaaga
     2041 tagtgatact gttagacaga aaattaatga tattcacgat tctaaaaaag gcaaagcaag
     2101 gatatctaaa aagaactcaa gttttacatt aagacaagta atttctagct atgaaaacga
     2161 tttggaagat gccaaaaaag tcaatcccaa tcttactaat ataaaagatt tttcagggga
     2221 tagcgagtcc cttgaaaagg aattagaaag ggttcagaat attgttcttc ctaatttaga
     2281 aattaaagct ctttcatcag aggatttgga atttttggat acttgtttat caaaaaatta
     2341 taagcttgaa gatattccca gctttaaaat tgttaattgg atagaagagg gactgagtat
     2401 acatcatcaa gatgaacatg agtgtttatt ttgtcatagt cagttgaata tagaggagat
     2461 taaattaaga gtagaaaaat ataaacgaaa tcaggttcaa aaagatactc aacgactgtc
     2521 tctcatactc gaaaagttaa aaaataattt atctctcttt aatgaagcaa aaaatagcac
     2581 aaattcttta cgaatattgg aagtctctga ggaagaaata cataactact atactataga
     2641 gagtgaacag ggactcatag aaattattaa tattattatt acaaaacttt ctgatatgaa
     2701 taatactcat tcagtaaatc ttgatagtat aaagaaattt gaaaatcagg tcaacaaact
     2761 agatctcaat ttaaagaatc ttcgtagttc taaattaaat agaattaata gtgacctatc
     2821 taatatagaa acattaacta agggggctat ttatttagct ataaaagata ctgatatttt
     2881 acagagcatt aattctatag aaaattctga aaaggagtta atatctatcg aacgatccaa
     2941 taatattaaa cgacttgaaa ttgaaaattt aaataaaagt ttatctgagt atagcgattt
     3001 tgcggagttt ttgaatgaag tattgaaaga tttagggatt caattctctt tacaattaca
     3061 tggtaaaaat tattatcttc agcataattt tcacgatgtt gttttgtcaa taaatgatat
     3121 tagtgagggt gaaaaaaatc tattagcttt gttatttttt tattttgagt tgtattctga
     3181 taaagaacaa ttacaaataa aagaaacaat tgagttaatt gttgttgatg acccgatatc
     3241 tagtttagat gaatcgaata gattttatgt actagaaatt ataaaaagga tttttgaaga
     3301 agaccaacca caagttttta tctttactca ttcttggaat gatttcagta gcttaggcta
     3361 ccgtttgaat gatgaaaatg tttattcgtt atttgaagtg tacaaaaaag aaacgagcga
     3421 ggttaggaaa attcatgaaa atttacctcc ttataaacta ctattcaaag aaattataga
     3481 ggtaagtaga aaaaattatt cagaagagct tactgaagcc gaaagatatc atactgctaa
     3541 tagcatgaga agagtttttg aagaattttt atattttaaa aagccaaatc tattacctca
     3601 acgtagtaat cattcagcaa ttgaagaatt ttatatgaaa gcaactggtg aaccacttag
     3661 taataactat cgcaggaaat taggtgagtt actaagtttt ataaatgtgc tttcgcacac
     3721 gccttatcgt tcagatgctg tgattgcgaa tgcaaaattt ttgatgaatc tcattcagaa
     3781 acttgataaa gtacattatg attcgatgat ttcttaaaaa atataattaa taaaatgaaa
     3841 gaaaaagaag gataggaagt aagttatgaa attacaagaa gtaagaaata tgttagggaa
     3901 tgattttgaa gccattattt ctgagtttga aagagaagga attgtatttg agtctcaatt
     3961 cagctctcta tattcgatgt tttgcaagaa gtacacatat caattagtta aattattgga
     4021 gaaagaaact caattagaag tatcctatgg ctatgcagtt ccatatttct actatttcga
     4081 tactaataga tttgaccgtt ctgaggctac cagaattgct ataaagtatc aaatagataa
     4141 aggaaatatg taataaaata gtttttggaa cggttaataa gattttcaca tatataagaa
     4201 tgttgatttg tcagcattct tttttatttc aaatgtattc tcggaattag aacatggggg
     4261 ttattaaact cttgattttt tcagcaagct atggtattct tttgttagtt aataaactta
     4321 caaaaaggag aacaaatgtt ttcacctact aaattaaaag aaaaaagaga aagtcaagga
     4381 ttatcgcaat cacaacttgc atccagtttg ggaatcagta gagcctcata ctttaattgg
     4441 gaatcaggta aaacaaaacc gaatcaaaat aatctaagta agttgagcca gattttaact
     4501 gtcgaccctt gctattttga atcagagtat gaaatagttg aaacttatct caagctaacg
     4561 gaaaagaatc aaaaagcgac acttcattat gctacagaat tgttgaacaa acagaatgcg
     4621 aaggttgtag acattcctga gcgttttgct tataaggtct acgaaaaatt atcagctggt
     4681 acaggaacag cttattttga tgatggtaat tacgatacag tttactttaa tcaccaattt
     4741 gattatgact ttgcatcatg ggtgtttggt aattcgatgg aaccaacata tgaaaatggt
     4801 tctgtagccc ttattaagca aacaggattt gattatgatg gagctatcta tgccatagat
     4861 tgggatggtc aaacctatat caagaaagtg tatcgtgaag aaaatgggct acgtttagtt
     4921 tcactcaatc ggaactattc agataagttt gcgccttatg atgagaatcc tcgtatcata
     4981 gggaaaatcg ttggaaactt tatgccttta gaggactgag tatgacttgg tttgattata
     5041 gtctcgaacc taaaagcgat attgccttta ttgatatgaa atctttttac gcaagtgtag
     5101 agtgtgtcga tagaggctta cacccgctta agacttcact ttgtgttatg agtcgagcag
     5161 ataattctgc tgggttaatc cttgcttcct ctcctatgtt taagaaggta tttgggaaat
     5221 caaatgttag acgttcctat gatttaccat ttgatgtaaa gactagaaag ttctcttact
     5281 ataatgctag aaaacaaggt ttgccgacaa cgatagacta tgtccgttat atagaggact
     5341 gggcaaaatc aacagtgatt gttcctccga gaatggatac ttatattgca gtcaatatgg
     5401 agattcaaaa aatctttcaa gattttgcag caccagacga tatttatccc tactcaattg
     5461 atgaaggatt tatcgattta accagttcat taaattattt tgtgcctgat aaaagtatta
     5521 gtcgaaaaga taagttagac attatctcag ctgctattca aaaaaagatt tggagaaaaa
     5581 caggaatcta ttcaacggta ggtatgtcta atgccaatcc cttattagct aagttagcac
     5641 tagataatga agctaaaaag actccgacaa tgagagccaa ttggtcctat gaagatgttg
     5701 aaaagaaagt atggtctatc cctaaaatga cagatttctg gggaattggg aatcgtatgg
     5761 agaagagatt acatagttta ggaatctttt cgattaaaga attggcacaa gctaatcctg
     5821 acttgattaa aaaagagctt ggtatcatgg gcttagagtt atggtttcat gctaatggga
     5881 ttgatgaaag taatgttcat aaaccttata agccaaagtc aaaagggata gggaactctc
     5941 aagttttacc tagagattat gtcaaaccaa gagatattga gatcatactt cgtgagatgg
     6001 cagaacaagt tgcggttaga ttgagaagag ctggtaagaa agcaactgta gtttctatac
     6061 acttagggta ttctaaagtg gaacagaaac gatctattca tactcaaatg aagattgaac
     6121 caaccaatca aacagcacta ctgacaaact atgttttaaa gttatttcac actaaatata
     6181 cttcaggagc tatcagaagt gttgccgtga gctattcagg tttagtagat gattcatttg
     6241 gattgatttc attatttgat gatgttgaga aaatagaaaa agaagaaagg ctccagtccg
     6301 caatcgatgc tattcgaaca gaatttggtt ttacttcact attgaaaggg aatgccctgg
     6361 atcaagcttc tagaacaatc gcaagaagta aactcattgg tggtcattca gctggaggat
     6421 tagatggact aaaatgatga atcgttctta tttacctttt ttgtctgcaa gagagtatca
     6481 agaccgtggg atggctaagt ggatgggatt ctttttatca gaacattcca gttctctttg
     6541 ggaagaaaaa aatagagaag atatctccat ttccctatca atggaagaga aagttctatt
     6601 tgttcgtcaa ctttatacga atgtattccc agcaactttt gtttgtaagc tctcaaatag
     6661 aagaaaagta gtatcgggta ttgttaaaga gattgggaga gagtctatat ccattaaatc
     6721 agactctggt tttcttcgat taagatggga agatatactc gatatccaga tagaaggggt
     6781 ggatttatat gaatcgtaaa gaattatatg acgataaatt gcagctggat tatttttcag
     6841 attcttattt acagtttgag tcagattttt acaagtattc agctttagat ataccattaa
     6901 catttatcac tgatgatatt ttacgcacaa tggctatgtc tcaaaaacat tattttaaac
     6961 ttaacaaaag taaatcttta gacggtcgtg accattactt tgttttttct atcaagatga
     7021 acaaagacag tagtggtatt agacagtatg aatatcagag acattgtttt aatttgtaag
     7081 agtccgacag ggctcttttt ctgtgataat tttatcaaaa agtatttgtt atactttttt
     7141 taatttagat ttatcttagg ggtttggggg cggagccacc aagttatctt atcgttggct
     7201 gtcaaaactg gaaggttttg atcggttgac gatatgattt ttgggatatt gtggacacaa
     7261 tatctgagct cgcaaagacc gaacaagaag cgagtgaggt ctttaggaag cgtaatgaca
     7321 atgtgaggta gactgacact gtcagacaag tagaatattg aagggatatc agaatgggac
     7381 aagaaattaa gtcaatccga aagcaattta gaattacgag acaagaagaa aaacagataa
     7441 aagaaatgat gagggaacaa aaagtggata gtttctcaga atttcttcgt caaaatttat
     7501 tgaaaaagaa ttatcaggat agaatttttg aaagttggtt ctccctttgg cagtctcaaa
     7561 agtttgaaca gattagtcga gatgtgtatg aagttctggt tgtcgcaaga gaaaatcatc
     7621 aagtgactca agagcacgtc tcaatcttat tgacttgcgt tcaagaattg attgcagaag
     7681 tgaatcaagt gcagccactc agtcgtgagt tccgtgaaaa atatatgggt taggaggatg
     7741 taatggttta tcgctatcgt accaatctca aaaaagtatt tctaactgat ccagaattac
     7801 accaattgaa tgaacggatt gctaagagca attgtcaaaa tttctcagtc tatgccagaa
     7861 aagtgttact taatcctaat atggcttttg tcacaattaa cacggatacc tatgaacagt
     7921 tagtgtttga attgagacgg attggaaata acatcaatca gattgcgcgt gcgattaatc
     7981 aaagccatct gatttctcag gaccaattac aagaattgag taaaggagtc ggagagttaa
     8041 ttaaggaagt ggacaaagaa tttcaagtgg aggtgaaaag actgaaggag tttcatggta
     8101 gttactaaac attttgcgac acatggtaaa aaatatcgta ggcgtttgat taagtatatc
     8161 ctcaatcccg ataaaacaga tgatttgaaa ttggtatctg attttggaat gagcaattac
     8221 ttggacttcc ctagtcatgc agaaatggta gagatgtaca atgtcaactt catcaataat
     8281 gataagttgt acgaatccag aaacgaccga caagaaaaac accaacaaac tattcatgcc
     8341 catcatctca tccaatcatt ttctcctgaa gataatctga cacctgaaga aattaaccga
     8401 attggttatg agaccatgat ggaattgaca ggaggtcgtt ttaagtttat cgtagcaacc
     8461 cacacagaca aagatcatgt tcataatcac atcctaatca actctattga ccgcaattca
     8521 gataaaaagt tgatatggaa ctatgccttg gaacgaaatc tccgtatgat ttctgaccgt
     8581 atttctaaag tggctggtgc aaaaattatt gagaaacgtt attcctatcg agattataaa
     8641 aaatataggg aatctagtca taagtttgaa ttgaaacaac gtctttattt tttgctgcag
     8701 caatctaaat cgtttgatga ttttttagag aaagcaaagc agttgcatgt tcagattgat
     8761 tttagtcaaa agcatagtcg attcatgatg acggatcgag caatgacaaa accaattcga
     8821 ggacgccaac tcagcaaacg agatctatat gatgaagaat tttttagaac gcattttact
     8881 aagcaagaga ttgaaagtcg tttagaattt ttgttgaacc gtgtcaattc tttagaagat
     8941 ttaataacaa aagcaaaaga attgaatcta accattgatt taaaacaaaa aaatgtaact
     9001 tttatcctgg aagaagataa tcaaaagata agtttgggtc atcaaaaaat aagtgataag
     9061 aaattatatg atgtcaaatt ttttcaagat tattttaaaa ataaggaagt cattgcttca
     9121 gaaggattag agaatttaca ggaacagtac catgctttcc aagaagaacg agataaggat
     9181 aaagtatcca ctgaagagat tgaggaagcc tttgagacat ttaaggaaaa acgagatacc
     9241 gttcgtgaat ttgaagtgga acttgcagag aaccaaatag agaagctagt tgatgagggc
     9301 atttatatca aagtgtcttt tggtattaag cagagtggtc tcattttcat tccaaattat
     9361 caattagata ttctggaaga agagaatcaa acaaaatata aaatctttat acgtgagaca
     9421 acctcatact ttgtatataa caaagaacat tcggataaga atcagtatgt caaaggacga
     9481 acattgataa gacagctaac caacgatggt cgagtaatac catacagaag acctacagtt
     9541 aagagtctac aggaaaagat tactgagatt aacctcttca ttgaattaac tgaagcagat
     9601 aagaaatacc aagacattaa agacgagtta gtaaaagaaa tagcagagat agatataaaa
     9661 ctaaatcaaa ttaatgaaaa aatcgccaac ttaaataaga tggcggaagt gcttatcaat
     9721 ttgaagagtg aggatgtgag cagtcgaaag cttgcaagat atgacttttc aaaattaaat
     9781 ttgccagaat caattacagt agaacaagta agcgaagaaa taagagcgtt tcaagaggag
     9841 ctagatcatt atctttatga gtatgagagc ttaataaaaa atttagaaat gtttgtaaaa
     9901 gtactgaatg ataaggattt tgataaaaaa tttagtatag aaatactatt ggaataacaa
     9961 gaactaatcc tatggcggtt aaagattaac tatctttatg ctattgatta atatatttgt
    10021 catagtgctc ttggtactgt gcttttatat tatgttctcc tagaatttca aatacttgaa
    10081 gtgcttgttt catcttttcg attccgttca caggattgca cttaaattca aagtatccac
    10141 atgtatataa gaagacggtt tgttcataat agtttaattc attatttagt aattttttta
    10201 tttctttgat tagaaaacta caattttgaa attcttcttt atcaatacta acaattaggc
    10261 aattgattgc caattgtgta acaagccgtt tatttgtctt atttaatgtt gaatagagat
    10321 aattttttaa catttctata gttaatagga agtaggagtt ataattaatt gttcttacac
    10381 agttacctaa taggataatt tcatagtaac cccagttttc aactttaaaa agataatctg
    10441 taagctgtaa taactcctcg tccgagggga gaaaattttt atttgtggta tagagaatcg
    10501 attttaccat tgtcttttca taaggaccca agttaaaact tgaagagttt gatagtaatt
    10561 caataatact agcaaaattt tttgaggagt agtgttttcg aatatattgc actaagttag
    10621 cgaatgatcc agttttagta gaattattgt catgaagaat aataaattca tccaaagtta
    10681 tatgtaattt atctaaaata ttgattagtc taatacaaga gatttctgat tctccacgtt
    10741 caaatctaga gatttgagat ttagataaat tactatcagc aattgaactt aaacttattt
    10801 tcttcccttt tcgaattttt ctgagtgtta taccaagttt tgatttcatt tttcccatat
    10861 tcccaacaaa attacaagga ttttttattt attatacaat aaataaaaaa ataaagggag
    10921 gttcagtatg aaaaaacttt taaaatttac atcaatattg ttattgatta tggatattat
    10981 cattatagtc ggaggttgat tcttactaat cttatacgta attcttagag gacatctatt
    11041 atgcaagaag ttattatcac aaataataaa agctggttat ttagttcgtc taagagacat
    11101 agaagacacc taaaaagggt tgttgcttat tgcaaagtta gttccgatag tgagaattag
    11161 aaaaacagtt acgattctca agtaagacac tacaaagaat atatttctca gcgttcagat
    11221 tggtaacttg cagatagtta tcatataaag gtatattagg aacaaaagta ggaaaaagac
    11281 aagcttttaa cgactaataa atgaaatgaa aactattata tttcactgat tactgtcaca
    11341 taaaacatat ttttatgagt aatgtattta ctttcattgt ataataacaa tagaaatact
    11401 attttagttt tactaaaatc tagaatattt gaaaactaat tggcttactt atatatgaaa
    11461 tcatccctaa tctgcaacaa ggagaggaag caatgaaaaa tttaggacaa atcttaaaaa
    11521 aaattcgaga agctaagggc ctctctcttt acaatattgc taatgatgag atttctacct
    11581 ctcagttatc tcgatttgaa aatggatata cagatattac tcttagtaaa ttactttcag
    11641 ttttaaagac actggacgta tctttagaag agtttatgta tttagggcgt ggttttcata
    11701 agatgagtaa tttcgaggta attgataaga taaataatta tttttataag aacaacagcc
    11761 cagccttgag aagactccta attaattgta tagaaaagga agaggagaaa ctaagtaaga
    11821 aattaacaat aattttgatt aagttaaagc tccaagaaat tgagaaagat aatattgtta
    11881 cttctgaaga aattgatttt atatcagact atttattcag catagatata tggggtgaat
    11941 atgaattaga gttattttcc tccacaatgg aaattttttg ccaatcaagt attatgatat
    12001 taacgaagga aatggtgagg agaactgatt tttataaaca tttaccgacc catagaagat
    12061 taattaccag catgttattt aatgctttta gcctcagcgt agaaagaaat aatatagttg
    12121 atgcatctta ttatagagaa caattagtcc agttattttt tgatgaaaca gaattatatg
    12181 aaagattagt ttttcacctc atagatagtt gttacaattt taagatgaca aatgaattga
    12241 gtaatatttt agagatgaga aagtgcattg gctttctgaa aaccttggaa agcatgagtt
    12301 tagtagataa atgggaaaaa tatattgaga gagtacttaa tagtaactaa ttgcaaattg
    12361 gggataaaaa ctattagacc aactgctagt gatataataa cattaggcag taggtctaat
    12421 agtttttata atcaaggagg attaatcatg actaagaaca ataagattga caacccgtct
    12481 gtaaaaattg aaaaagcaac tgttgtaaat aacaaaggat gtagtgtttg cgcgattggt
    12541 gctgtttgtt tagctgacgg tccaattcct gattttgaaa ttgcaggagt atctgctgta
    12601 tttactgcat ttggataatt gctaattata aattaaatat ctaatatata atgacctact
    12661 gcttattttt tgattgaaag aggataaaaa tgtatttagt gttggataat caagttacaa
    12721 tatatcaaac taaaggggac tataatgtaa tcgttgagaa aatcgatgcg aataaacgga
    12781 aacaatttga ctattttaca gttaataaaa caggaaaatt acttctagaa gctatcaacg
    12841 gcaagcaaaa tatggaggaa tttatagaaa actttattga tacttacaac ttagtagaag
    12901 atgatcgaaa ttggattgag acatttttaa atgaaatgat gaaaaaagga gccattgcaa
    12961 tcaaagagag cccagagatt gcaaatttgc cattatatat ttatggaaat tcaagactta
    13021 tttctccttt acatgtaaca gttgagatta ctgaaaaatg taatttatat tgtgctcatt
    13081 gctatttaaa tgcatcctgt aacaaaacaa ctgcaattga ttacgagggt ttcaagtctc
    13141 ttgtgaaaaa actaaaagcg agtaacgttt tgagtattga aatcactggt ggagaagtat
    13201 ttatgaataa ggatgcagaa aaaatactag aattggcatt taatgagttt agtagagtag
    13261 ccttattaac aaacggtaca atactcaaga aaagtagctt gtcgttatta gagaaaaaca
    13321 aagataaatt agttatgagt atttctttag acagtgttag agaggaatta catgataagt
    13381 ttagaggtat gcgaggctca tttaggagta cttgtaaaaa tattaagcgt ctgacagaag
    13441 cgggaataca tgtacgagta gcttcttcta tttttgatga aaatatgtgg gaggttgata
    13501 aacttgctga gcttgcaatt gagttaggag cggaactttt tgtttataat tttgtagaaa
    13561 atttcggcag aggtacggat ttcaataaaa atagtagtac gaaattttcc aaagagtact
    13621 cacgttattt gagtgagacg gtatttaagt atagagcatt aattccaatt atcgaatcgg
    13681 aggattatct aaaatcttct tctaattgtg gtgctggaac aaatactatt ttaattggtg
    13741 cagatggtaa tttaagacct tgtcctatct ttcctaagaa taagattttc aaaaatataa
    13801 acgatggtag tatggaggaa attttttctg atgatgttta tcaaaaaatt agcaatatct
    13861 atccccctag tgatgaaaac ggttgttcta aatcttgtcc aaattacagt aattgttttg
    13921 gatgctacat gaaaggactg gaaagtaatg tagataaagc accagaacaa tattgttctt
    13981 ggataactta taataaatta gagaagttta tggaacaata taagggaggg aaggttattg
    14041 agtaattatc ttttttctta taaatattat agacctattc ctaatttatt tattaaacaa
    14101 aaactaagag aaattcataa gttacttaag gaagatttaa taaaatttgg aatcgaaaac
    14161 ggaataataa tttcaatttt tgctctcggt tgtaatggga gaatgacaga aattatttat
    14221 ataaaatcaa tgtatcgtat ttctgaagat aaaatctatg atatgttaga ttttttatat
    14281 aataaagaaa ttgaacttta caaggtggta aaagatgata acattaattg tacaatatct
    14341 tgctacggag taactgcaaa tgcttctatt cctacaaaag agtccttagg atacttttta
    14401 aaaaattttt taaaatggga aaattatagt gtcaaaaaat attctagagt taaattagaa
    14461 actacagaaa atattataat taaagaagga gaattaacgt atgtcggttt cctatgtgat
    14521 aatatagaga taaaagaatt aggagatatg ctgtcagcta agttattaga agaaattttt
    14581 aaatcacaaa atagcgtttt aacagagatt agaaatcaag gactttgtta cacaactgta
    14641 tcaaagtttc atgaagattt gaacgttgtt tatatcggac taataacaag ttattcagaa
    14701 gataaaattt ctagattaga taccatgtat accaatgttc agttaactga gggcgagttc
    14761 gaacttgcta aatgtcgatt gaagaaagaa ataatatttt caacaacttt atatcaaata
    14821 gaccattact tattaccttt tcagctattg aaaattgatg caaatgtatc aactttgtta
    14881 gaaataatcg ataaaataaa attcgaagat attgtgaaaa tctttaatag caggagaata
    14941 gtgtgtttaa aagcataata aggaggaagt taatggagaa agattgtacg ttttttatta
    15001 aaccagtttc agatttagga gaagttacta ttgaaagaat aatttttaat tttaatggtt
    15061 caattaggga agggtattta caccttttag aacatctatg ggttagagct aataagtcgt
    15121 ggtttgatga ttatgaaagt aaaatgaata tttttaacgc tttaacggat aagaatcgaa
    15181 ttacatttat tttgatatat acagaatcga cagttaatac caataagtta atatttgatt
    15241 taaattttaa tgaacaggac ttcttgatcg aaaaaaagac tatttacgaa gaaagaaaat
    15301 tatattcgga tagtacacca gacgttgata ttgttttagg aagtcttaga actattgaag
    15361 cctttgattt aatagtttta aaaaacatga tgcatcagat gaattataaa aaaattcgat
    15421 ttcatttttc ctcaaaaaac aacggcaaat atatgaaaaa tcccactatt aatataaaaa
    15481 aaaattcgat aatttggaag gattctaata ctattcaact caaagatttt tatgattata
    15541 aagtgttgtt aaccatttta aaagtgttta aattaacgaa tgaaagtttt tgttttaata
    15601 tcaacgaggc aaaagaaaat tatgagatca catttgatga ttacgaagtc tttgatttta
    15661 tgctaaaaaa taaagataat gtcttaaagc gataccagct actacttact aatactcaat
    15721 tatttataga acagacaatt tatttatttg atctttttgg ttttaatctt gatatattag
    15781 acttttggag agaatttaat tgggaggttt tagaaaaatg aaaaaaaagc aacaattcta
    15841 tttctaatca acctagttct attagcatta agaaatatag ttaatagtta ctgcaattta
    15901 gaatttaaaa taacaatcag agattttata gtgttaggag ggatattaat tctatgtgaa
    15961 cagaaatata taaaggtact actatctatc ttatctacaa gatctgcttt aactaactat
    16021 aaacaaattg agtatctaat ttatctgata aatgctaata ttctgatgta cacattgata
    16081 atgtatttta acactttttc tttttcgtca tcattcatca atttatatta taaaaattac
    16141 ttcttaaatt ttttaatact tatattttct ttttcttatc taattataaa atataagttg
    16201 ctggttatta aatataaata tgttttaatt atattgactt tccttcttat gggtgttagt
    16261 gtattagact tgataacatt tgtttttttg gcaattattt catttatctc tagtagatta
    16321 acaaagttca acactaatta tttctcagca ataatatttc cgatggtatt aacttattat
    16381 attatgtttg ataaaaatat attttctata gtttgtacat gtttattact ttttagctgc
    16441 cttgtaccaa taatcttaga aaggaaatta aacaatgaac aaaaaactta gactcgcaat
    16501 tgctatttgc ttttttgtag gtgcatttat gtttgttttc atgaaagaat ttctttatgc
    16561 agttgctttt atgatagtgg gtggagtata tctgtataaa ggagtgagat aatttgacaa
    16621 ctctattaga actaaaaaaa ttgaattttg catatgttaa gaatagtaaa atattagata
    16681 acattgattt aattttaaat caaaacaaag tctatggttt gattggaaag aacggtgctg
    16741 ggaaaacaac gtttattaaa attttaagta gtgtatttaa caataatgtt tttactctgg
    16801 aatattttaa gtttttcgat aaagaagtcc agctgagttc agaattttat cgacaaaata
    16861 agtatacagt atttacagaa agtgaaagct ttttaaactg gacttttttg caatatttgg
    16921 aaatggtctg tcaactttat aattgttcga tagaaagaaa aagattggaa tttttagtta
    16981 acggatttaa atttgaagag tattgccaaa aagagatcag agacctctct actggtaata
    17041 aaaagaaagt tttcttgata gtaggattat atcttagaag acctttattg attttagatg
    17101 aaccgtttga cggtttagac ttcgagtcca cggaattttt atataagatg ttactggagt
    17161 ataagcaata tggtacagtt ctgttaagta ctcattttgc agagagtgtc gtaagagttt
    17221 gtgattatct ttatattcta gaaaatgctc acataaactt attccaagga aatgtgtctg
    17281 aatggttaga gtctatcagg aaataaggag gaaatctgta atgttatgga tatccatatg
    17341 tagagatttg ttttcgcgga aaagatttta ttttttggga ttctctttaa tactagtttt
    17401 actcatacga catttaatac cttctcataa caatgcgaac tatcttctat tttctgcaac
    17461 actaattacc ttagtaagta cttggcaact acttttatca tatttcaaat cagaaagaat
    17521 ccaggcatac tatcaacttc ctatttctaa cacaaaattt tatatccaat ttatatttgt
    17581 gtcatttgca tctaatctaa tcgaaagatt gtcattgtta atcattcttt ttagtgaagc
    17641 aaaattaata aatttgatac tacctatttt atcttccctc tttgttatta tgagtagctt
    17701 tagattagtt aggtgttttg gaactttaaa aaataaagtg actaagcttt tattattcct
    17761 ttatattttt atttcactat cattgtttct cttactgaaa tcaatttatt tgcttttgtt
    17821 catgattgct attgagtgga tttttatttt aagagatgat aattttttgt atttagatga
    17881 tttttcaaat acaaatcatt ttttaaagtt taaaaattat tttgtttcaa atttggtaaa
    17941 agagagatat ttttatttta atactgtcgc ctcagtatta tttattttaa tattatattt
    18001 tcaagaacta cctgaaaact taaaaattcc attacttttc actgtagcat ctactaatac
    18061 acctcttact agtttaattt ctagcgagcc acaattaaga atacatttgc gatcactacc
    18121 taaatcttat attttttaca atatgtatct aaggtgttta ttatactatt atctttttat
    18181 aaattttcta attgcaattg tctatattac tagttcacac agtataatat ttttagtatg
    18241 ggtaggggta tttactttat ttgagagtgc gttatatcta tttttagaaa agtattggta
    18301 tattaaaaaa tggaacataa agaaggaact atggaaacat cctcgcaaat atattgttcc
    18361 tatgatgact tatctatttt tctttattct actaatgtta aagaaattct aaagcccatt
    18421 tgtagaataa agtgtaacat agtatttaat cctttcaagc tgtttgagtc aactcaagca
    18481 gttttttcct ttgtttaaat aaaactaaaa tttagtattg ttcagcttca gagaaatgat
    18541 tgtatgattt atttgtgaac attttcctat aattttgtaa tattcttaag actataatat
    18601 atcagataaa catgtctttt gtgtttcact ttattttaca ataatactaa tttttgaagt
    18661 cagtaatttt aaatagttga taaaatcttt tctctcagac ggttaataga tatgcttatt
    18721 agaagtgttt aataaattaa ttttagttca aaatgtccaa tttggacact ttgaatgatt
    18781 tcttagtttt atatattata cttttctcag gagaaagcta gatgtacaga cgtttgagag
    18841 atttgaggga agatcacgac ttgacccaaa aacaaatagc tgaaatactt tcgtttacaa
    18901 actcagctta tgctaaaatt gaacggggtg agcatgcctt aacggcagat gtattggtaa
    18961 ctctctcaaa cttttacgat gtcagtacag actacctatt gggattgaca gattttcctg
    19021 ataaaattcg ctttagaaaa taatctcctc aatttcatag agtgtgaaaa tgaggagatt
    19081 attttatttg gttctttgac aattaaatag tccaaaatgg tactttcctc atttgtggag
    19141 cagttttgaa tggctcgcca tgataagagc gacataaaaa ccatcaataa aatagagcga
    19201 tactttatat gccatgatac aaatgatata caatgatact tctgaccgtt caggctgcca
    19261 acgtaaaaga gcagcaagtg aaattcttat gatgacttca tcagtcatgc catggaggag
    19321 aaaatatttt ttaggaagga tgatgatatg aatataaaat atatatctgt cgaaaattcc
    19381 attgcagaat gggccgataa aaagggaatt ctaaaaagat gggatggttt aaatcaatat
    19441 acattgaaca gatggattaa agaaatgcga gaaaacagaa cattttccat gtatgtaatt
    19501 aacccaaccc ataaacttgt tttcattaat ctagaaggat ttgaaagttt cttaagatgg
    19561 aagcaaaagc ggacaaaata aggaagtcat ggtataatat agggtagtta tttattctat
    19621 acaacaatga tttatttctt tttaagagtt aagaggaatt aaattatgta ttatgtaact
    19681 aaaacaaatt caaaagggca acccttatat caagtggttg aaaagtacaa agatccacta
    19741 acaggaaagt ggaaatcagt aactgtaagt tatactaaga atactagtag ggcgaggaaa
    19801 caagctgaaa gagaggttct tgataaaata gatagactaa ctacttcatt tgaaagtcag
    19861 tatagtcctg aactgattac aacatttgga gagttaaaag aaaattggtt tcagacttgg
    19921 tgtgtctctg ttaaaccaca aacaattcag agagaactac tggttatgaa gcgtcttggg
    19981 aaaattatag gagatgattt tttgttagac aggattactc cacttctaat gaaaaatagt
    20041 ctcaataaat atttagaaat gtatgatgca tcgccttcaa caatgactca tataaaaagt
    20101 acttgtaata agatttttaa tcatggtgtg ttatataatg tcattaagtt ttctccaatg
    20161 actgcggtaa aactagatat ttcactagag aaaaggcgta aagcaaaaga aagacatgat
    20221 tctaaatttc tagaaatcca tgaattacat gcattttttg atgtgttacg ccaatgcaga
    20281 aatgcaaact attatgatct tgctatagta ttgttgctta caggtattcg aattagtgaa
    20341 gcagcatttt taccatcaga tattgatttt gaaaaaggaa tcttgcatat tgataaagca
    20401 cttcaatatc attgtttaaa agttaaacaa tttcattttg atacaactaa aacactcaat
    20461 tcaattagag aagtagcttt gcctgaagct gcaagcgaag ctattaaaag gacaatacag
    20521 agaaataaag attttgatgc ttatatgaag aaacatccct gtcctgcttt tacacattct
    20581 gaaagtgtat ttagaacaga atacggctct ccaataacat caagcacttt tcgtcaaatt
    20641 ttgaaacgaa tagaaggaaa attattgaca aattgtttaa gtgactatgg ttttaagtgg
    20701 gtaaaacatg ttactcccca ttcgtttagg catatgcata ttagttacct tcaaagcaat
    20761 gagatgcaca tagcagtgaa agatattatg actagagtag gacatgctaa ctttgagaca
    20821 acaatgggct atacacataa tataaatcgt tcacaagaaa atactgtaaa agccttaaat
    20881 caatttgtag aaaatcacaa tttccatttt gaagaattga aaagttatac ctgtaaatat
    20941 tccagaatga ttgaaaaatt cattgaaact agtgataata gcaataaagt agaattaagt
    21001 gttgatgagt tcaaagactt gttacatctt agtccacgtt actcacctaa aaatattgtt
    21061 tcaaatttac tattaaaaat caaaaaagat attgtcaaat accacccaca gtttgatata
    21121 aagattgtga aatcaagcga gaatcaaatc agaggttttt ccattgcatg gtagttttgg
    21181 tgttcgcttg gtgtttagac aatagtaaaa taaaataggg gctctaaacc cttgctacga
    21241 aaggaaaaaa actcaatggc tactattcaa tggtttcctg gtcacatgtc caaagctcgt
    21301 cgacaggtgc aggagaattt aaaatttgtt gattttgtga cgattttggt agatgcacgc
    21361 ttacctctat ctagtcaaaa tcctatgttg accaagattg ttggcgacaa accaaaactc
    21421 ttgattttaa acaaggcaga cttggctgac ccagcaatga ccaaggaatg gcgccagtat
    21481 tttgaatcac aaggaattca gacgctagct atcaactcca aagagcaagt gactgtaaaa
    21541 gttgtaacag atgcggccaa aaagctcatg gcggataaga ttgctcgtca gaaagaacgt
    21601 ggtatcaaga ttgaaacctt gcgtaccatg attatcggga ttccaaatgc tggtaaatcc
    21661 actctgatga accgtttagc tggtaagaaa attgcagttg taggcaataa accaggtgtg
    21721 accaaggggc aacaatggct caaaacaaat aaagaccttg aaatcctgga tacaccgggg
    21781 attctctggc ctaagtttga ggatgaaact gttgcgctta agttggcctt gactggagct
    21841 attaaagacc agttgcttcc tatggatgag gtaactattt ttggcctcaa ttatttcaaa
    21901 gaacattatc cagaaaagtt ggccgaacgc ttcaaacaaa tgaaaattga agaagaagct
    21961 ccggttatta ttatggacat gacccgtgcc cttggtttcc gtgatgacta tgaccgcttt
    22021 tacagtctct tcgtgaagga agttcgcgat ggcaaactcg gtaactatac cttagataca
    22081 ttggacgacc tcgatggcga cgattaaaga aatcaaagaa ctccttgcta ctgtcaagga
    22141 cttagataac cctatttttt tagagcttga aaaggataat cgctctggag ttcaaaagga
    22201 aatcatcaag cgtaaaaaag ccattcaggc agaattggag gaggatcttc gtttggaatc
    22261 catgctttcc tatgaaaaag aactttacaa gcaaggattg accttaattg ctggtgttga
    22321 tgaggtcggc cgtggtcctc tagctgggcc tgtggttgct gcagccgtca tcttacctaa
    22381 aagttgtaag attagaggtc tcaacgacag caagaaaatt cctaaaaaga aacatctgga
    22441 aattttccaa gccattcaaa accaagccct gtcaatcggc attggtatca tggataatca
    22501 agtcatcgac caagtcaata tctatgaagc aaccaaacta gccatgcagg aagcaatctc
    22561 ccagctcagt cctcaacctg agcacctttt gatagatgcc atgaaactgg atttaccaat
    22621 ttcacaaaca tctatcatca aaggagatgc caattccctt tcaattgcag cagcttctat
    22681 agtcgccaag gtgacacgtg atgaattgat gaaggaatac gaccagcagt tccctggcta
    22741 tgattttgct gctaatgcag gttatggaac agctaaacac ttggaaggac tgaaaaaact
    22801 aggagttacc actattcatc gaaccagttt tgaacccatt aaatcgctgg tttcaggaga
    22861 aaaagaaagt taagttagaa ggaatgatta tggaggaaca gtcagaaata ctcagttcca
    22921 agaaagaatt cgcctttgcc tcaagcacca tattatccca agttggacga ggaatcatcg
    22981 tcggtctcgt tgttggaatt atcgttggat cctttcgctt cttaattgaa aaaggcttcc
    23041 acctgataca agggctttat caagatcaag cgcacctagt gcgcaatctt tttatcattg
    23101 gtctatttta tttaatagtt tgttggctca gtgcgaaatt aactcggtca gaaaaagaca
    23161 tcaaaggttc aggaattcct caagttgaag ccgaattaaa gggactcatg accctcaact
    23221 ggtggggcgt tctttggaaa aaatatgttc taggaattct tgcaattgcc agtggactca
    23281 tgctggggcg tgaagggcca agtattcaac ttggagcggt cggtggtaaa ggaattgcta
    23341 agtggctcaa atccagtcca gtagaggaac gctccttgat tgctagtgga gctgcagcag
    23401 gattagccgc agcctttaat gcaccaattg cagggcttct ctttgtcgtg gaagaagtct
    23461 atcatcactt ttctcgcttt ttctgggttt ctaccttggc tgctagtctc gtagcaaact
    23521 ttgtttctct gctcatattt ggcctaacac cagtactgga tatgccagac aatattcctc
    23581 tcatgaccct agaccagtat tggatttacc tcctcatggg aatttttcta ggactttctg
    23641 gttttctcta tgaaaaagct gtactcaatg ttggtcgagt ttatgactgg cttggtcaaa
    23701 aaatccgttt ggatagagct tattacccaa ttcttgcctt tattctcatc ataccagtcg
    23761 gcatcttctt accccaaatc cttggtggtg gaaatcagct tgtactttcc ttaactgagc
    23821 aagattttag tttccaagtt ctattagctt actttttgat tcgctttgtt tggagcatga
    23881 ttagctatgg aagtggcctt ccgggtggaa ttttcctacc aattttggcg cttggttcct
    23941 tgcttggagc cctagttggt gtcatttgtg tcaatcttgg tcttatcagt caagagcagt
    24001 ttcctatatt tgtcattcta ggaatgagtg gctattttgg agcga
//
