LOCUS       NZ_CP047883            20261 bp    DNA     circular CON 27-JUL-2024
DEFINITION  Streptococcus mitis strain S022-V3-A4 chromosome, complete genome.
ACCESSION   NZ_CP047883
VERSION     NZ_CP047883.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus mitis
  ORGANISM  Streptococcus mitis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2086958)
  AUTHORS   Pinzauti,D., Iannelli,F., Pozzi,G. and Santoro,F.
  TITLE     Complete genome sequence of the tetracycline resistane Streptococcus
            mitis isolate S022-V3-A4
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2086958)
  AUTHORS   Pinzauti,D., Iannelli,F. and Santoro,F.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-JAN-2020) Department of Medical Biotechnologies,
            University of Siena, Viale Bracci, 16, V lotto, I piano, Siena, SI
            53100, Italy
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-NOV-2018
            Assembly Method                   :: Unicycler v. NOV-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400.0x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013305725.1-RS_2024_07_27
            Annotation Date                   :: 07/27/2024 01:18:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,027
            CDSs (total)                      :: 1,952
            Genes (coding)                    :: 1,893
            CDSs (with protein)               :: 1,893
            Genes (RNA)                       :: 75
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 24 of 59
            Pseudo Genes (incomplete)         :: 39 of 59
            Pseudo Genes (internal stop)      :: 19 of 59
            Pseudo Genes (multiple problems)  :: 16 of 59
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:35:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 299529
            Orig. end                         :: 319790
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047883.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Francesco Santoro.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20261
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="2"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20261
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20261
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10261](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10261
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            129..410
                     /locus_tag="M594_RS01535"
                     /old_locus_tag="M594_01560"
     CDS             129..410
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865240.1"
                     /locus_tag="M594_RS01535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01560"
                     /product="hypothetical protein"
                     /protein_id="WP_000005472.1"
                     /transl_table=11
                     /translation="MSETTLVVQLPKELEKQLRAHYDEMISNAVARVFEDKELYKPMVR
                     MSGLSRWLDVSTTTIQKWTKEGMPTMVIDGVTLYDKRAVTRWLKQYER"
     gene            419..1258
                     /locus_tag="M594_RS01540"
                     /old_locus_tag="M594_01565"
     CDS             419..1258
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001014724.1"
                     /locus_tag="M594_RS01540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01565"
                     /product="phage replisome organizer N-terminal
                     domain-containing protein"
                     /protein_id="WP_001014727.1"
                     /transl_table=11
                     /translation="MNGVQWIKITTDIFDDEKIQLIESMPEGDTLIVIWFKILVLAGKQ
                     NNSGILSLGNKVYYTEEMLSTVFRRKATSVKLALSMFEEFGMIEIIDGAITIPKWEKHQ
                     NIDGLEKIRKQTRERVARHRQKQKALITGEPQLVLDCNVTVTDENDNVTQEIKNKSKNK
                     KEIENILDNSSRKPETYIPPKYYSLLESISYKYNDRFLYPNNYTLTHAQKMKIGEYLAS
                     GYVTSDEVISMIERIPEDATSPLAYLFKSMENLKQERMLECKAIAHENARKKYMINE"
     gene            1251..1610
                     /locus_tag="M594_RS10025"
     CDS             1251..1610
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865242.1"
                     /locus_tag="M594_RS10025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000092745.1"
                     /transl_table=11
                     /translation="MSRYRTVLKKCYITEEQNEIVNNLIEMTNHLSFSSYARKMLFKSS
                     PIYLQFDFESYHDFIFQVRRIINNLRQLERIAEQSEDLDNVRIFHYCVELMIEYEKKTS
                     KQVKELVKRLNKKTR"
     gene            1618..1950
                     /locus_tag="M594_RS01545"
                     /old_locus_tag="M594_01570"
     CDS             1618..1950
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220782.1"
                     /locus_tag="M594_RS01545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01570"
                     /product="hypothetical protein"
                     /protein_id="WP_001220782.1"
                     /transl_table=11
                     /translation="MRIKSVLKQVFLTEEENKKLNDCMRKENIRNFSEFARQKLIRTDL
                     NIQKVSFEGLVPLTEELEQVGKNINSIARLATVVGRISYENKMDMSILMQKIVDVMEEK
                     DVYFQK"
     gene            1931..2125
                     /locus_tag="M594_RS01550"
                     /old_locus_tag="M594_01575"
     CDS             1931..2125
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000469567.1"
                     /locus_tag="M594_RS01550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01575"
                     /product="hypothetical protein"
                     /protein_id="WP_000469564.1"
                     /transl_table=11
                     /translation="MFIFKSNMDKDFDQICEYILKLKRAELFLHGIKQQDKTKARLYHA
                     MLEYYDANHKKERHMRILK"
     gene            2438..>2957
                     /locus_tag="M594_RS01555"
                     /old_locus_tag="M594_01580"
                     /pseudo=""
     CDS             2438..>2957
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000662270.1"
                     /locus_tag="M594_RS01555"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="M594_01580"
                     /product="methylase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKENLIKSKKRVQKHGEVFIPFWMVQKILDTPGIKETCEDISATF
                     LEPSAGDGKFLQAILERKLSAVIM"
     gene            complement(3214..4673)
                     /locus_tag="M594_RS01560"
                     /old_locus_tag="M594_01585"
                     /pseudo=""
     CDS             complement(3214..4673)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094141.1"
                     /locus_tag="M594_RS01560"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01585"
                     /product="IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLDNQLTMDVSPYSSLYDIVVPKTHFLRQLIELCDFSFIYDELEK
                     NYRPDFGRKAYSPIMMFKYLLLKDIYKLSDVDVVGRSLSDMAFKFFLGLAPEDSVIEPS
                     SLTKFRKLRIKDDKLLDVLIQKSVQIALEHNLIKSKILIVDATHTKSHYNHKKPQEILR
                     ERSKALRKTIYQHSEDIKIEFPKKPQEDNLEAELTYTEELMAVVEKHEELLALPAVSQK
                     FNYLKEAVEDDLEHLEASVKEEARLGHKTADTSFYGYKSHIAMTDERIITACVVTSGEQ
                     SDGKYLPELYAKTKENSLDIETIIGHAAYSGKNNIQLTRKEKIHLVSKLNPSVFQKVTV
                     KKRMRLNLIKTQGYLSVQKDTWLFAKQGQGKNIKIRIKLSLITLTLKSARIVFPRKGVI
                     RREQSLKLIHWLLRVTTIFSRRNFRKHLILKKWPDIAIKSKRRMPN"
     misc_feature    4961..4972
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.13"
                     /tool="antismash"
     gene            complement(5072..5539)
                     /locus_tag="M594_RS01565"
                     /old_locus_tag="M594_01590"
     CDS             complement(5072..5539)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002920900.1"
                     /locus_tag="M594_RS01565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01590"
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="WP_084888180.1"
                     /transl_table=11
                     /translation="MTEKIKNWVNICVLKNQEILLLNRQHDNFPGWIPPGGKVEFPESF
                     FEAALRELKEETGLTALNLELKGISGFTNSIGNERFVFYDFLCTQFTGELSTSDEGEPK
                     WWNLKDIDKIPMQDDIRKRIPLYLRKGSFESINYWDNNKKCISENKTILFD"
     misc_feature    complement(5495..5507)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            5851..6072
                     /locus_tag="M594_RS10185"
                     /old_locus_tag="M594_01595"
     CDS             5851..6072
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024252.4"
                     /locus_tag="M594_RS10185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01595"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_368039306.1"
                     /transl_table=11
                     /translation="MDGIGYVLRNLRLNKGLTQKYIYKNLCSRKQLSRIENNTSYPSVY
                     LLYYICQRLEVTTDYVISLTLERGNHAK"
     gene            6062..7108
                     /locus_tag="M594_RS01575"
                     /old_locus_tag="M594_01600"
     CDS             6062..7108
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014592.4"
                     /locus_tag="M594_RS01575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01600"
                     /product="S-adenosylmethionine:tRNA
                     ribosyltransferase-isomerase"
                     /protein_id="WP_173875783.1"
                     /transl_table=11
                     /translation="MLNDTNKLKYELPVELAAREPVELMSGSRDSSRLIIGFKNSDKII
                     DDYILNFHNYINPGDLIILNNSKTVSPIFYAYSEKYGEVKFHIKTKNEEGYVIYIRIRS
                     DLQDGIISEKFFLSDKINVTVDKNINGEEFLCSFNCSQEDLYDYLLVHGEAVRSIYTRK
                     KWSIAYYQNGIANKLGSFENPAANRHFSNRILRALRKKGVKIGYITLNCASVDTKIFEE
                     FIEEHSVFKEYYEIPEETAELIRDTKLNGNKIFAVGTTVIRTLESCEYDNFKIVSPLKN
                     YTDLYIYPGYNFKITDALITNFHGSMTSRLALSAAVIGTENIMNLYRHAIDEQYLFYEF
                     GDANLLFM"
     gene            7296..7577
                     /locus_tag="M594_RS01580"
                     /old_locus_tag="M594_01605"
     CDS             7296..7577
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M594_RS01580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M594_01605"
                     /product="hypothetical protein"
                     /protein_id="WP_084930088.1"
                     /transl_table=11
                     /translation="MAYKISHDIDITEDNGYQVLHRYSDDTYFSLQKDYLFILLSYNGL
                     NNLNDIAKVFSNHKGISINCSLEYVEKVQNYFISERIIFKDENKNHSY"
     gene            7552..8460
                     /locus_tag="M594_RS01585"
                     /old_locus_tag="M594_01610"
     CDS             7552..8460
                     /EC_number="2.1.1.45"
                     /GO_function="GO:0004799 - thymidylate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006231 - dTMP biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012524.4"
                     /locus_tag="M594_RS01585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01610"
                     /product="thymidylate synthase"
                     /protein_id="WP_084930089.1"
                     /transl_table=11
                     /translation="MKTKTILTNNLCENNIDSLYVKLCKLLEDNGQHIVSRGMAVKELI
                     GVSIVLTEPKRRFLENSARNLKLYYAIGEFLWYLRGSNDLSEIEYYAPSMAKFSDDGSI
                     LQGAYGPKIVPLIDDLIQLLKNDTGTRRAVIPLYSADDLGKESKDIPCTLSLEFLIRNN
                     KLHLITNMRSNDIFLGLPYDIFSFTMLQEYIAYQLGVDLGCYYHYVGSLHVYQRNFKKI
                     EEISQMSPHETAIFNKSDSIFKNFSEIIDLEESIRKNKTFNHNLNLLMDSDFQKIKTEL
                     ENYRYSREKNVERKTDIYMRY"
     gene            8423..9025
                     /locus_tag="M594_RS01590"
                     /old_locus_tag="M594_01615"
     CDS             8423..9025
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014299.4"
                     /locus_tag="M594_RS01590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01615"
                     /product="AAA family ATPase"
                     /protein_id="WP_084930090.1"
                     /transl_table=11
                     /translation="MSNGKLIYICGIDGSGKTTLSKNLSKNLGSNSIFLPLNQSKIFFK
                     ELDSICRKYNTNRWAEFSEIFRGCLWALEMVYFSEKILKPALEQYDYVIIDRYMTCNKV
                     YSNLSITNTLVDRLHELLIQPKITMYIDIEPKIAFSRVIKRNEQQTPKETLENLKIAKE
                     LYARYLNNLEYYRLDGRESEERLLQSALGILGDKNEI"
     gene            9015..9998
                     /locus_tag="M594_RS01595"
                     /old_locus_tag="M594_01620"
     CDS             9015..9998
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M594_RS01595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M594_01620"
                     /product="hypothetical protein"
                     /protein_id="WP_084930091.1"
                     /transl_table=11
                     /translation="MKFETILDFYIFYLEELLNGSQKQKVPYSAISDKIEIFNNSVEIS
                     HGNLINMMFSKSELNYNIVHTLFSLSGRTDAYILKKYKSAYLRYSDDGFYQNTVGERLY
                     TLYGNQIKRSYGFLKDDIFSPDAICFMKANDNNNIDCTFYVHFYYREERLNVELTYKGS
                     HLLEYTNSDLFIYSSLLSLMSHWLGVKAGSLILKTHSIFISERDKERTEKLLDSCRLLK
                     KVDLSLNHDFSSSLKSYREEFSDAINRVITWDIVEVSKRLNNEIEYINNNFTPYTQDLL
                     FILLADRFHSNTEEYKTILDKINNDSIRCFKETVDRTEFNSILEVV"
     gene            10001..10261
                     /locus_tag="M594_RS01600"
                     /old_locus_tag="M594_01625"
     CDS             10001..10261
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="M594_RS01600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01625"
                     /product="PqqD family protein"
                     /protein_id="WP_158086604.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 6.5e-07,
                     bitscore: 26.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.8e-10, bitscore: 37.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYKKSLSAVLHSSSDKDFLLNLLSDRTFLLNDVSLYIWNSIEKY
                     SLEDIAINLSNLYNENLDIVRQDLHEMIEILVSEGLIEIKN"
     aSDomain        10040..10252
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M594_RS01600_Stand_Alone_Lasso_RRE.1"
                     /evalue="9.30E-09"
                     /identifier="RREFam002.1"
                     /label="M594_RS01600"
                     /locus_tag="M594_RS01600"
                     /protein_end="84"
                     /protein_start="13"
                     /score="26.2"
                     /tool="antismash"
                     /translation="SSDKDFLLNLLSDRTFLLNDVSLYIWNSIEKYSLEDIAINLSNLY
                     NENLDIVRQDLHEMIEILVSEGLIEI"
     gene            10280..10960
                     /locus_tag="M594_RS01605"
                     /old_locus_tag="M594_01630"
     CDS             10280..10960
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M594_RS01605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M594_01630"
                     /product="hypothetical protein"
                     /protein_id="WP_084930093.1"
                     /transl_table=11
                     /translation="MCNNDYTLITKEISNLVSEKNIVIWKSEMDGLGTSLSDIDAYCIC
                     DEEKNFKNFSFNGIPVDIEYIGLNNLKEKLENIDKFAKHGLAYKGLDEDLKLFYRLERG
                     HKSQQFNLNDIELPTIDVISKIAAQYYNELFLALYEDAFKMFHGKNFLDAFILSLEALQ
                     MSVATYLARIGKPQFKKKWLFKYFDNLTDCSYYEELRIELESDTILPERISKILSDSKK
                     ILEF"
     misc_feature    11211..11231
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 23.31"
                     /tool="antismash"
     gene            11256..12056
                     /locus_tag="M594_RS01610"
                     /old_locus_tag="M594_01635"
     CDS             11256..12056
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.4"
                     /locus_tag="M594_RS01610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01635"
                     /product="phosphotransferase"
                     /protein_id="WP_173875784.1"
                     /sec_met_domain="APH (E-value: 2.2e-07, bitscore: 27.9,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFLLNIYYGLSDIKFIERLENMNVVYIFKNSKTGNKILLKIFSS
                     SKVDTIVFQNELAKYKLSPNLIKTNKGNIYIRVFKYLIFVQYFVEASSRRIEYSEMVIF
                     FKDFYAKLDYYKNFFLETSIGFPNYKTNAISQHFSMIHGDLRPPNVIITANNFSVIDFE
                     YLRLGVREVEVIKYIVLYTNFNNCEVEILYSKFLEAGIVEISLQESIRFLLFELLKSDF
                     PEKYIVRITLDYYNEIISERIKLIEFCDNYLNKKKGGDLSVSRS"
     gene            12040..13086
                     /locus_tag="M594_RS01615"
                     /old_locus_tag="M594_01640"
     CDS             12040..13086
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014038.4"
                     /locus_tag="M594_RS01615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01640"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_173875785.1"
                     /transl_table=11
                     /translation="MSVEVEKKYLLTSDEYYALSKSHFEGAIIQEQLNYYFDSLDFSLL
                     KRGITLRIREKANNLILTIKRKISINDVIESEENDFLISRIEFMEAVLRGEFPKKVEQK
                     LNVLIPKKKIFYLGLLKTQRLIKEKDSILYCLDRNTYFDKQDFELEIEGTRESLQKVSV
                     DIPEKKFNRVGKYSRFISELLKGNGNSLIKIQVSAIILNEDKDEVCLIKKNAPTSSVHN
                     IWIPPGGHVDIGEDLLKAVKRETIEETGLEVEILALSSVVSFQIQQTSQAICFFYLVEA
                     KNCGEITMLEPGMDCKWFNLADVISGNITNLTDYHKLIISNSKNTNTLYLDLEKKGLDY
                     KILNSKIL"
     gene            13145..13939
                     /locus_tag="M594_RS01620"
                     /old_locus_tag="M594_01645"
     CDS             13145..13939
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000599441.1"
                     /locus_tag="M594_RS01620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01645"
                     /product="ABC transporter permease"
                     /protein_id="WP_173875786.1"
                     /transl_table=11
                     /translation="MLTAIIRRNWQMYVRYFPITLFFNRILDIGFKLLGLWLVSNFLFD
                     NKIQVNNVIEYRDYFSYAAIGLIFYNVSIAILMNVGRALITEVREGTLESTLVSPYSIV
                     KYYFGIFFEQLGRTFLEFLSSYSIAFFLGANLQSISLLNLIICFLYVSLISFSMGTLLS
                     NIMLWFRDTFITQNTLFLIIFLVSGITFPKELLPSFLQKISKMIPLSHSLDAIRNLFFN
                     TSHFNIYNFDFLQGILISVVYFIVGLLVYKKIEQKIVSYISY"
     gene            13955..14926
                     /locus_tag="M594_RS01625"
                     /old_locus_tag="M594_01650"
     CDS             13955..14926
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895179.1"
                     /locus_tag="M594_RS01625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01650"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_173875787.1"
                     /transl_table=11
                     /translation="MLKAINISKNYTFKKRTGLFQYEKQIKKAIVNVNLSLPKGKIIGV
                     LGENGAGKTTLIKMLTTLLTNDTGIILIDGVDINENLKNTRKKINIISGGEKNLYWRLT
                     AVENLIYFASLYGISKREALPKIEKLLIELGLWNSKDIPVEKYSKGMKQRLQIAKGLIN
                     DPEYLFLDEPTLGLDVSVAHELRKKLKEIAIKRNTGILLTTHYMAEAEELCDYIYFLKK
                     GKIIISGTKDEVFDKLELAPEIHITLAPQFQWNSMEIKRLRDLFPELEYRKEENLTLIK
                     FSLLKYKVQSVIKTIYERNIDIIEIKHTEPSLEDVVLHLERR"
     gene            14961..15731
                     /locus_tag="M594_RS01630"
                     /old_locus_tag="M594_01655"
     CDS             14961..15731
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M594_RS01630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M594_01655"
                     /product="ABC transporter permease"
                     /protein_id="WP_173875788.1"
                     /transl_table=11
                     /translation="MRRTLFNDSTNIFYFFSMILWPIFSLLQVYYNIGAFPISDLKILD
                     LSNEEQLFYFIFIGYCTYIIFSNAFQSAWRLGGERYQGTLSQIFIAPLKKILWLYARTF
                     SSIFSQSWFFMVIFVIGNFAYIDFSLKSIFHILLATIILITSSWIWTSFLSSICIVMRD
                     ATIVYVLLEGSQDTFSGAKVPLSISPKLVKFIGSLFPVSYTIIYLRDMLLFNKFYSLNF
                     YLLIGINIVCFLLTNIILRIGESHMKKHGSFDVV"
     gene            <15796..16542
                     /locus_tag="M594_RS01635"
                     /old_locus_tag="M594_01660"
                     /pseudo=""
     CDS             <15796..16542
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001082309.1"
                     /locus_tag="M594_RS01635"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01660"
                     /product="ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="DVGTGSEFNVIKEVTFDDALPKLIVKVRDFIRTQLREFQYLDSDG
                     RFQILPEYPEFAWFEGIVNAVTHRNYSVYGDHIRVLMFDNRLEIHSPGKLPNIVTVENI
                     RHERFSRNPRIARTLTEFGWVREMNEGVKRIYSEMESAFLHEPCYSEPGNKVVLTLENS
                     ITSRTLRTRDSLESKLRDYSDLSVDEKLLIQYMYNTAEPMTTKKVAEFLGRSVSYSSKL
                     LKTKGILTWYGTSTKDRSQYYKLEMK"
     gene            complement(17056..18273)
                     /locus_tag="M594_RS01640"
     CDS             complement(17056..18273)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015647386.1"
                     /locus_tag="M594_RS01640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_173875789.1"
                     /transl_table=11
                     /translation="MSITKTKNGTYRLRIYIPEEVKSSLGVDKKVIEKRFKTRSEAKKY
                     ELELQNKIDKIISGESALLENNGSILFSDFYKNVWWESYKAGQTTSTTKPPSQATITGT
                     EIAFRKHILPMLGNYSIEFLNQNKQVVLNLLTQKAEEYANFKVIRSYVNSIFDWAEELE
                     YIETNRLSKTISRIKATKKIKLQESKKDEDLYLSQEELQAWFTAFEKDLDTGKILFKDY
                     VLFYTTFFLGDRKSESYALQWKHINTSDQEIQLVQALDKYKNPKSTKGNKKTTFRIPIE
                     LTNLLKEWKKQQKDELAKFGIIQSNEQYVFTYIDMKGNVNSPLHSDYLNNKMKSVKRRH
                     PELKHATPHKLRHTGATLAKQAGTSIEAISEALTHSDTITTKTYVNTSNIIPMAVGEIA
                     YRNLKK"
     gene            complement(18342..18602)
                     /locus_tag="M594_RS01645"
                     /old_locus_tag="M594_01670"
     CDS             complement(18342..18602)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003013637.1"
                     /locus_tag="M594_RS01645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01670"
                     /product="AlpA family transcriptional regulator"
                     /protein_id="WP_125837281.1"
                     /transl_table=11
                     /translation="MQVILPDEQVQQIQLLLAELIKKEIENRLNNSNLDSPFLNKQQTC
                     HYLGISNNTLDSWIKKGLPYIRVGKTIRFDKAEINRWLQNQ"
     gene            complement(18651..20021)
                     /locus_tag="M594_RS01650"
                     /old_locus_tag="M594_01675"
     CDS             complement(18651..20021)
                     /GO_component="GO:0005727 - extrachromosomal circular DNA
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003916 - DNA topoisomerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000044268.1"
                     /locus_tag="M594_RS01650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M594_01675"
                     /product="Rep family protein"
                     /protein_id="WP_254597175.1"
                     /transl_table=11
                     /translation="MTSIAITQYFDSTYWKNGWDEELIKSENIEKILEEIVRRVSEIAT
                     VTEAYAIKHDKDTSVVFDKELQETTTELAQPHIHALLKFKKCKGATLSTLAEIIGLAEE
                     YLEKSKSGRYGYDNLLAYLIHAKDKDKYQYSPDEVVTLAGKDYLEVYHKRKEIWLKGKA
                     KKEVNQTYEDIDLLIDNILNEYITKNEILLEQKYRTLYAVHKARINDTFRTVGEIKGTR
                     TKYELDNGEFKKTILFIHGSTGLGKSTFAKDLSKAIIQLAKLNGQNWQSVVTAATNIFD
                     EVNGEEILFLDDVRGDSLTASDWLKLLDPFNISPISARYQNKMGAAKVIIITSSKYPLD
                     FFYNTKGNDREDLSQYVRRIECLARIRGNDKNPKFYVSYPQRMEEPVKTILENEQEVSL
                     SYDFANDSLLNSRQDLLSTLLSKIAINNQWDILELGKSKTPSETLASEDEVADNQEK"
     misc_feature    complement(20128..20143)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.61"
                     /tool="antismash"
ORIGIN
        1 ttataacaca ttttattctt tttgaataaa aaagcttgac aaaaattcaa aaaggatata
       61 taattcaaaa tgaataacaa attaaatggt ttcggagctt atttaattta gaaatgaggt
      121 gtgaatttat gtcggaaact actttagttg tccagcttcc taaagaatta gagaagcaat
      181 tacgtgctca ctatgatgag atgatttcaa atgctgtagc aagagtattt gaagataaag
      241 aactttataa acctatggtt cgtatgtcag gtttgtctag gtggttagat gtatctacga
      301 caacaatcca aaaatggacg aaagaaggaa tgccaaccat ggtgattgat ggagtgactt
      361 tatacgataa aagagcagta acacgatggt tgaagcaata tgaaagatag gtactcgtat
      421 gaatggtgtt cagtggatca agataacaac agatatattt gatgatgaaa aaattcagct
      481 aatagaatca atgccagaag gagatactct tattgtaata tggtttaaaa ttctggtgct
      541 tgcaggaaag caaaataata gtggcatatt aagtctaggg aacaaggttt attacacaga
      601 agagatgctt tcaacagtgt ttaggcgaaa ggctacatct gtaaaattag ctctcagcat
      661 gtttgaagaa tttggcatga tagaaatcat agatggcgct attaccattc caaaatggga
      721 gaaacatcag aatatagatg gactagaaaa gattagaaaa caaactaggg aacgtgttgc
      781 tcgtcataga caaaaacaaa aagcactaat tacaggcgag ccacaactcg ttttagactg
      841 taacgttaca gtaacggatg aaaatgataa tgtaacgcaa gagattaaga acaagagtaa
      901 gaataagaaa gagattgaga atatactgga taatagttct agaaagcctg aaacttatat
      961 tccacccaaa tattattctt tgttagaatc catttcttat aagtacaatg atagattttt
     1021 gtatcctaac aattacactt taacacatgc tcagaagatg aagataggcg agtatttggc
     1081 tagtgggtat gtaactagtg atgaagtcat tagcatgatt gaacggattc ctgaggatgc
     1141 gacgtctcct ttggcgtatt tatttaagtc tatggagaat ttaaagcagg aacgtatgct
     1201 ggagtgcaaa gctattgccc atgaaaatgc ccgaaagaag tatatgataa atgagtagat
     1261 ataggactgt tctaaagaaa tgttacatca ctgaggagca aaatgaaata gtgaataact
     1321 tgattgaaat gacaaatcat ctaagttttt cctcttatgc cagaaaaatg ttatttaaga
     1381 gctcgcctat ttatcttcaa tttgattttg aatcttatca tgactttata tttcaagtta
     1441 gaagaattat caataactta cgtcagttag aaagaatagc agaacaaagt gaggatttgg
     1501 ataatgtaag gatatttcac tactgcgttg agctgatgat agaatatgaa aagaagacaa
     1561 gtaaacaagt gaaagaactt gtaaaacgac taaataagaa aacgaggtga taggaccatg
     1621 agaataaaat ctgtgttgaa acaggtgttt ttgacggaag aagaaaataa aaaattaaat
     1681 gattgtatga ggaaggaaaa tattcgtaat ttttctgagt ttgctagaca aaaattaata
     1741 cgaacagatt tgaacatcca aaaagtctct tttgaaggtt tagttccttt aacagaagag
     1801 ttggaacaag tcggaaagaa tatcaattct atagcccgtc ttgcaactgt agttgggaga
     1861 ataagctatg aaaacaaaat ggatatgtct attttgatgc aaaaaatagt tgatgtgatg
     1921 gaggaaaaag atgtttattt tcaaaagtaa tatggataag gattttgatc agatatgtga
     1981 atacatattg aaattaaagc gagcagaatt atttcttcat ggaattaaac aacaagataa
     2041 aacgaaggct cgtttgtatc atgcgatgct ggaatactat gatgctaacc ataaaaaaga
     2101 aagacatatg agaattttaa aataaggaaa cgctgttaaa aattttgcag cgttttttat
     2161 atatcttctt aaaatatttg tacacacaaa tgacagtcaa attgattttt gggattattt
     2221 tatcgagaag gaaagatttc tcataatatg actttgcgag ctcagagtct gtatacacac
     2281 actcccaaaa tcatcctaaa atttgtatac acaaagtgta tgtacttttt gggatgattt
     2341 gaattttggg gaatccccaa ccccctttag aaatagttag atataagatt aaaaaatggt
     2401 ataatcttaa aagataaacg tttttaagga gtagactttg aaagagaatt taatcaaatc
     2461 aaaaaagcgt gttcaaaagc atggagaggt ttttatacca ttctggatgg tacagaaaat
     2521 attagatact ccaggtatta aagagacttg tgaagatatt tctgcaacat ttttagaacc
     2581 ttctgcagga gatgggaaat ttttgcaagc tattttagaa agaaaattat ctgctgttat
     2641 catgtaatat gcaatatgat gaaagaagtt ggaagacaaa atcattgatt gcattatcat
     2701 ctatatatgg gatagaattt ctcgaagata atttagaagt agcacgttca cgtatgtttc
     2761 tttattattt agattggtac gaacaaattt ttagtactaa gctaactagt agaagtgaca
     2821 tctataaatc tgcatattat cttattcata aaaatatagt tagaggaaat accttaactc
     2881 aacgtcatcc tgttacagat gaacctattt ggtttaatga atggcaactt ttcaaaggcc
     2941 attctagttt ggtaagactg ggcaaaaagt ctttaaaatt agaaaacgca tagtatcaag
     3001 tgttaaatcc ttgatattat gcgttttatt gttagaaaat ttgctttatt ttctccttaa
     3061 gttgagtttt tgcccagcct ctatcagagc ttttaggtaa aaagttgagg ataatacagt
     3121 tgtagaagga cgaacccact gaaaaaataa ggagcttact tttaatgaaa ggaaaatcga
     3181 ggaatctttc atcaatttga gcgaattcct cggttatttt gtatttatta aggtcataat
     3241 tcgttttata ttgaccacga agatggttgt ggctgcctgt aactccatgc tgaaaagacc
     3301 cgatgctctc gcgacatcaa agccatgtct ctgttttagt tcggcattct tcgcttcgat
     3361 tttatagcga tgtctggcca tttctttaaa ataaggtgtt tcctgaaatt tcttctggaa
     3421 aagatggtcg ttactcttaa tagccaatga ataagtttta aactttgctc cctcctgata
     3481 acacccttcc ttggaaagac aattcttgca cttttcaatg tcaaagtaat gagtgacaac
     3541 ttgattctta ttttgatatt ttttccctgt ccttgctttg cgaacagcca agtgtccttc
     3601 tggacagaca aatagccctg cgtctttatt aaattcaaac gcatcctctt ctttacggta
     3661 actttttgaa aaacagaagg gttcagtttt gacaccaaat gaatcttttc tttgcgagtt
     3721 agttgaatgt tgttctttcc cgaataagct gcatgaccaa taatagtctc gatgtccaga
     3781 ctattttcct ttgttttggc atataactca ggtaaatatt tcccatcgct ttgttcacca
     3841 gaagtgacca cgcaagcagt aataatccgt tcatccgtca tagcgatatg acttttatat
     3901 ccatagaaag aggtgtcggc tgtcttatgt ccgagcctag cctcctcctt aacagaagct
     3961 tccaaatgtt ctaagtcgtc ctcgacagcc tcttttaggt aattgaactt ttgagaaaca
     4021 gccggtaggg ctaagagttc ctcgtgtttt tcaaccacag ccattaactc ctctgtatag
     4081 gtcaactctg cttcgaggtt atcttcttga ggtttctttg gaaattctat tttgatatct
     4141 tctgaatgtt gataaattgt tttacgtaaa gcttttgaac gctctctaag gatttcttgg
     4201 ggtttcttat gattataatg agatttggtg tgagtggcat ccacaatgag gattttactc
     4261 ttaatcaagt tatgttcgag tgcaatttga acagacttct gaatcaatac atcaagcagt
     4321 ttgtcatctt taattcttag ctttctaaat ttcgtcagag aggatggctc gataacagaa
     4381 tcttcaggag ctagaccaag aaaaaattta aaggccatat ctgacaagga acgtcctacc
     4441 acatctacat ctgataactt ataaatatct tttaacaaga gatatttgaa catcataatc
     4501 ggtgaataag ctttacgccc aaaatcggga cgataattct tttctagttc atcataaata
     4561 aagctaaaat cacagagttc aattagctga cgtaaaaagt gggttttagg aaccacgata
     4621 tcatacaaac tagaataagg actgacatcc atagttaact gattatcaag cattatttca
     4681 cctcatctct agtataacaa aaaagccatc aatttgatga ctttttcagt gggctcatga
     4741 aacgctatga gtttttttgt tgtactatat tttacaattt atcattataa aataaatgct
     4801 gaactttttg aaagcttcta atttggaaaa attagaattg ctgaaaagta agagtacatt
     4861 aatgatattt tatgaatata tgtacacaca ctaattagtt ataaatatga gaaacgaaaa
     4921 ttatattagt gttgttgaac tcggctaaag gaaaatggga gaaaaagtta tcaattgaac
     4981 gatacttcag taccaataaa attgagtact aaagtataca aaaattacta atggattgag
     5041 acttttgtat ttgattatac tgtagagaat attagtcaaa taaaattgtt ttgttttcac
     5101 taatgcattt cttattatta tcccagtagt taatactttc aaagcttcct tttcttaaat
     5161 aaagcggtat cctttttctt atatcatctt gcattggtat tttatcaata tcttttagat
     5221 tccaccattt tggctcacct tcatcagatg tgcttagttc accagtaaac tgagtacata
     5281 aaaagtcata gaagacaaat ctctcattac caattgaatt agtaaagcct gaaattccct
     5341 ttaattcaag atttaatgca gtgagtccag tttcttcctt aagctcccgt agtgcagctt
     5401 caaaaaaact ttcagggaat tcaacttttc cccccggtgg aatccagcca ggaaaattat
     5461 cgtgctgtct attaagtaat aaaatttctt gatttttcaa aacgcaaata ttaacccagt
     5521 ttttgatttt ttcagtcata ttatcaacct ccaataagta ttttttcata tattagacta
     5581 tatgtcaaga actatatgct atttatgatt gtgacaaatg tgtctcagct aaagattgat
     5641 gatttttatg aaatagctga taaactctca gatatgacga taaaataatt tttataaggc
     5701 tagttaccct tattatactg tggcaaaaaa tagaatttca ttgattttct gtatatattt
     5761 tctagtgatt caaatgggac atatgtgggt cttgttttac ttttaagaaa agttgataat
     5821 aaaatcaaga tatctgaagg atgtgaagaa atggatggta taggttatgt attgaggaat
     5881 ttaagactta ataaaggatt aactcaaaaa tatatttata agaatttgtg tagccggaag
     5941 caattatcta gaatagagaa taatacttct tatccctcag tatatctttt gtattatatt
     6001 tgtcaaagat tagaagttac tacagactat gttattagtc taacgttaga aagaggaaat
     6061 catgctaaat gacacaaata aattgaaata tgaattaccg gttgaattag ctgctcggga
     6121 gccagtagaa cttatgtcag ggagtcgaga tagttcaaga ttgattattg gatttaaaaa
     6181 ttcagataaa attattgatg actatatctt gaattttcat aattacatta atccaggaga
     6241 tttgattatt ctaaataata gtaagacagt ctctcctata ttttatgcgt actctgaaaa
     6301 atatggggaa gtaaagtttc atataaaaac aaaaaatgaa gaaggttatg taatttatat
     6361 cagaattagg tcagatttac aggatggaat catatcagaa aaattttttc ttagcgataa
     6421 aataaatgtt acagtagata aaaatattaa tggtgaggaa tttttgtgca gttttaattg
     6481 ttcacaagaa gacttatatg attatctcct agtacatggt gaagctgtaa ggtctattta
     6541 tacgagaaaa aagtggtcca ttgcttatta tcaaaatgga attgctaata aattaggttc
     6601 atttgaaaat cctgctgcta accgacattt ttctaataga attttaagag ctttaagaaa
     6661 aaaaggcgta aaaattggat atattacttt aaattgtgca tcagttgata caaaaatttt
     6721 tgaagaattt attgaagaac atagcgtttt caaagaatac tacgaaatac cagaagaaac
     6781 tgcagaatta attcgagata ctaaattaaa tggaaacaaa atatttgccg tgggtacgac
     6841 tgttataagg actttggaaa gctgtgagta tgataatttt aaaattgtat ctccattaaa
     6901 aaattatact gatttatata tatatccagg ttacaacttc aaaatcacgg atgcattaat
     6961 tacaaatttt cacggttcaa tgactagtcg ccttgcgtta tcagcagcag taattggcac
     7021 ggaaaatatt atgaatttat atcgacatgc aatagatgag cagtatttat tctatgagtt
     7081 tggagatgct aatttattat ttatgtaatc caataattat agttcatgga aaggaggtga
     7141 tcaaatgaaa aaattaactt tgaaagaatt ggttaataaa gcaagtgatt tgcttgcctg
     7201 ttgcaatgca actaaataat taaccgaatt caaattttta acttcaatga aaaaaatatc
     7261 aaattttttc attgaagttg tttatggagg aatttatggc atataaaatt agtcacgata
     7321 tagatattac agaagataat ggatatcaag tattgcatcg atactcagat gatacgtatt
     7381 tttcattgca gaaagactat ttatttattc tgttaagtta taatggtctg aataatttaa
     7441 atgatattgc taaagtcttt tcaaatcata aaggaatttc aattaactgt tcattagagt
     7501 atgtagaaaa agttcaaaat tattttattt cagaaagaat tatattcaaa gatgaaaaca
     7561 aaaaccattc ttactaataa tctatgtgaa aataatattg attcgctata tgttaagtta
     7621 tgtaaattgc ttgaagataa tgggcaacat attgtttcaa gagggatggc agtaaaagaa
     7681 ttaattggcg ttagtattgt tctaacggag cccaaaagac gatttttaga gaactctgct
     7741 aggaatctta aactttatta tgccatagga gaatttttat ggtatttacg agggagcaat
     7801 gatttatccg aaatcgagta ttatgctccg agtatggcaa agttttcaga tgatggttca
     7861 atacttcaag gggcatacgg tcccaaaata gtacccctaa ttgatgactt aatccagctt
     7921 ttaaagaatg atacaggaac tcggcgtgct gtaataccct tatatagtgc agatgatctt
     7981 ggtaaggaaa gtaaagatat cccatgtact ctttctttag aatttttaat tcgaaataat
     8041 aagctacacc ttattacaaa tatgagatca aacgatatct ttttaggtct accatatgat
     8101 attttttctt ttacaatgct tcaagagtat atagcgtatc aacttggagt agacttggga
     8161 tgctattatc attatgtagg aagtttacat gtataccagc gtaattttaa aaaaatagaa
     8221 gagatatctc aaatgagtcc tcatgagacg gcaatattta acaaatcaga ttcaatattt
     8281 aaaaatttta gtgagataat tgatttagaa gaatctataa gaaaaaataa aacttttaat
     8341 cataatttaa atttattaat ggactcagat tttcaaaaaa ttaagacaga gctagaaaat
     8401 tataggtata gtagggaaaa gaatgtcgaa cggaaaactg atatatatat gcggtattga
     8461 tgggtctggt aagactacat tatccaaaaa tctttccaaa aatttaggaa gtaattctat
     8521 ttttttgcct ttgaatcaat ctaagatatt ttttaaagaa ctagattcta tttgtcgtaa
     8581 atacaataca aatagatggg cagagttttc cgaaattttt agaggctgtt tatgggcatt
     8641 agaaatggtt tatttttctg aaaaaatttt aaaaccagca ttggaacagt atgattatgt
     8701 aattattgat aggtacatga cttgcaataa agtttattct aatttatcaa ttacaaacac
     8761 cttggtagat agattacatg agctccttat acagcctaaa atcacaatgt atatcgatat
     8821 agagccaaag atagctttta gtagagttat taaaaggaat gagcaacaaa cgcctaaaga
     8881 aactttagaa aatttaaaaa ttgccaaaga attatatgct agatacttaa ataatttaga
     8941 atattatcga ttagatggta gagaatctga ggaaagatta ttacaatctg cactaggaat
     9001 attaggagat aaaaatgaaa tttgaaacta tattagattt ttacatattt tatttagagg
     9061 agttacttaa tggatctcaa aagcagaaag taccctattc agctatttct gataaaattg
     9121 aaattttcaa taatagtgta gagatatctc atggaaatct cattaatatg atgtttagta
     9181 aatcagaatt aaattataat attgtgcaca cattattttc tttaagcggc aggacagatg
     9241 cgtatatttt aaaaaaatat aaaagtgcgt acctgagata ttcagatgat gggttttatc
     9301 aaaatactgt aggtgaacgc ttgtatactt tatacggtaa tcaaataaaa agaagttatg
     9361 gttttttaaa ggatgatatt ttttcaccag atgctatttg ctttatgaag gcaaatgata
     9421 ataataatat tgattgtact ttttacgtac atttttatta tagagaggag cgtttaaatg
     9481 tagagcttac atataaaggc tctcacttat tggagtatac gaattctgat ttatttattt
     9541 actcttcatt actgtcatta atgagtcatt ggctaggtgt taaagcaggt agtttaatat
     9601 taaaaactca ctcaatcttt atttcggaac gtgataaaga acgaactgaa aaattattag
     9661 atagctgtag attattaaaa aaagttgatt tatctctaaa tcatgatttc tcttcaagtt
     9721 taaaaagcta tcgagaagaa ttttctgatg caattaatcg tgttattact tgggatattg
     9781 tagaagtatc aaaaagatta aacaatgaga ttgaatatat aaacaataat ttcactccat
     9841 atactcagga tttattgttt atactccttg cagatagatt tcatagtaat actgaggagt
     9901 acaaaactat acttgataaa ataaataatg actctattag gtgttttaaa gaaacagttg
     9961 atagaacaga attcaattcc attttagagg tggtttaatt ttgaactata aaaaaagttt
    10021 atccgcagta ctgcattcgt cgtcagataa ggattttcta ctaaatttat tgagtgatcg
    10081 aacattcttg cttaacgatg tttcattata tatttggaat agtattgaaa aatacagttt
    10141 ggaagatatt gctattaact tatcgaattt atataatgag aatttagata tagttagaca
    10201 agacttacat gaaatgattg aaatactggt ttctgagggt cttatagaga taaaaaatta
    10261 aaagataggg agaatttata tgtgtaataa tgactacact ttaattacta aagaaatatc
    10321 aaatttagta tcagaaaaaa atatagtaat ttggaaatct gaaatggatg gcttaggtac
    10381 atctttatct gatattgatg catattgtat ttgcgatgaa gaaaaaaatt ttaaaaattt
    10441 ttctttcaat ggcatccctg tagatattga atatattgga ttaaataatc taaaagaaaa
    10501 attagaaaat attgataagt ttgcaaagca tggattagcg tataaaggac tagatgaaga
    10561 tttaaaattg ttttacaggc tagaacgagg tcacaagagt cagcaattca atctcaatga
    10621 tatagaatta cctacaattg atgttatttc taaaattgca gctcaatatt ataatgaact
    10681 ttttctagca ttgtatgaag atgcatttaa aatgtttcat gggaaaaatt ttttagatgc
    10741 ctttatactc tcattagagg cattacaaat gtcagttgca acatatttag ccagaatagg
    10801 aaaacctcag ttcaagaaaa agtggttatt caaatatttt gataatctga cggattgctc
    10861 ttactatgaa gaattaagga ttgaattgga gtcagataca attttacctg aacgcataag
    10921 taaaatatta tctgattcaa aaaaaatcct agaattttaa attttcatat tgaaaggagg
    10981 tgaggattat ggcttataaa aaacctatcg taaaagatat taaattgagt gcttctacaa
    11041 ttcttcgtta atatcttgac tcttaaagta gagatttgaa caggattacg gatggttaaa
    11101 gctaataaaa atcaatatga aatatattct tgatgctaga ctattagtat tgaattaaca
    11161 atgtatttat ggctctaaag ttttataatc tacagttcac ctctctgctt tttttgtgat
    11221 attgaatatt aataatgaaa tttaagatac tatgtgtgaa attcttatta aatatatatt
    11281 atggtctaag cgatatcaaa tttattgagc gacttgaaaa tatgaatgtc gtctatattt
    11341 tcaaaaatag taaaacagga aacaaaattt tgctaaaaat tttctcatct tcgaaggttg
    11401 acactatagt atttcaaaat gaacttgcaa aatataagtt atctccgaat ttgataaaaa
    11461 ctaacaaggg taatatatat ataagagtgt ttaaatatct aatttttgta caatacttcg
    11521 ttgaggcaag tagtcggaga atcgagtata gtgaaatggt tatatttttc aaagattttt
    11581 atgcaaagct tgattattat aagaattttt ttttagaaac aagtattggt tttcctaatt
    11641 ataaaaccaa cgcaatcagt caacatttta gcatgataca tggtgattta cgaccaccga
    11701 atgtaattat aactgcgaat aattttagtg taattgattt tgaatattta agactcggag
    11761 taagagaagt agaagtgatt aaatatatag ttctgtacac taattttaat aattgtgaag
    11821 ttgaaatttt atatagtaag tttctggaag ctggtatagt agagataagt ttacaagaat
    11881 caattaggtt tttacttttt gaattactaa aatcagattt tccagagaaa tacatcgtga
    11941 gaattactct agattattat aatgaaatta tatccgagag aataaaatta attgaatttt
    12001 gtgataatta tttaaataaa aagaaagggg gggacttaag tgtcagtaga agttgagaag
    12061 aaatatttgc ttacaagtga tgagtattac gctcttagta aaagtcactt tgaaggtgca
    12121 ataattcaag aacagcttaa ttactatttt gatagtttag atttttcact tttaaaaagg
    12181 gggataactc ttagaatcag agaaaaggcg aataatctga ttctaactat aaagagaaaa
    12241 atttcaatta atgacgtaat tgagtcagaa gaaaatgatt ttttaataag tcgaatagaa
    12301 tttatggaag cagtattgcg tggagaattc cctaaaaagg tagagcaaaa gttaaatgtt
    12361 ttaatcccca aaaagaaaat cttttatttg ggattgctaa agacacagag actaattaaa
    12421 gaaaaagatt caattttata ttgtttggat aggaatactt actttgataa acaagatttt
    12481 gaattagaaa ttgagggaac acgagaatca ttacagaaag ttagcgttga tattccagaa
    12541 aaaaagttta atagagttgg gaaatattct aggtttataa gtgaattatt gaaagggaat
    12601 ggtaattcat taattaagat tcaagtatct gccattattt taaatgaaga taaagatgaa
    12661 gtatgtctta ttaagaaaaa tgcacctaca tcaagtgtgc ataatatctg gattcctcca
    12721 ggtggtcatg tagatattgg ggaagacctc ttgaaagctg taaagcgtga aacaattgaa
    12781 gaaacaggat tagaagttga aatattagct ttgtcaagtg tcgtttcttt tcaaattcaa
    12841 caaactagtc aagccatatg tttcttttat ctggttgagg ctaaaaattg tggtgagata
    12901 acaatgttag aaccaggaat ggattgtaag tggtttaatt tagcagatgt gataagtgga
    12961 aatattacaa atttaacaga ctaccataag ttgattattt ctaattcaaa aaatacaaat
    13021 actttatatt tagatttaga aaaaaaaggc cttgattaca aaattttaaa ttcaaagatc
    13081 ctctaaaatg ttttagtgta ctataattaa aattatagtt ttggtaaaaa tataaggagt
    13141 gaatatgctg actgctatta taagaagaaa ttggcaaatg tatgtaagat attttcctat
    13201 aactttattt tttaatcgta ttttagatat tggatttaaa cttctaggac tctggttagt
    13261 gtctaatttt ttatttgata ataaaataca ggtaaataac gtaatagagt atagagatta
    13321 ctttagttat gctgcaattg ggttaatttt ttataatgta tcaatagcta ttttaatgaa
    13381 tgtaggtcga gcattaataa cagaagttag agaaggtact ttagaaagca cgttagtgtc
    13441 accgtatagt atagtgaagt actattttgg aatctttttt gaacaattag gaaggacttt
    13501 tcttgaattt ctttcttcgt attcaatagc gtttttttta ggtgccaatt tgcaaagtat
    13561 ttcattatta aatttaatta tttgtttttt atatgtatcg ttgatttctt tctcaatggg
    13621 aacgctttta tcaaatatca tgttatggtt tcgtgatact ttcataaccc aaaatacatt
    13681 gtttttaatt atttttttag tctcagggat tacctttcca aaagaattgc tacctagttt
    13741 tttgcaaaaa attagtaaaa tgattccttt atctcattcg cttgatgcta ttagaaactt
    13801 attttttaat acttctcatt ttaatatata taattttgat tttttacaag gtattttaat
    13861 ttcggtagta tattttattg tagggctttt ggtgtataaa aaaattgaac aaaagatagt
    13921 aagttatatt tcatattgag tttaggagat aattatgtta aaagcaatta atatatcaaa
    13981 aaattatact tttaaaaaaa gaacaggctt atttcagtat gaaaagcaaa taaaaaaagc
    14041 tatagtaaat gtaaacttat ctttaccaaa aggaaaaatt attggagtac tgggagaaaa
    14101 tggtgctggt aaaacgacac ttataaaaat gctgacaaca cttttaacga atgatacggg
    14161 tataatttta attgatggag tagatatcaa tgaaaactta aaaaatacaa ggaaaaaaat
    14221 taatattatt agtgggggag agaaaaattt atactggaga ttgactgcag ttgaaaattt
    14281 gatatatttt gcatccttgt acggaatttc aaagagggaa gcattaccta aaatagaaaa
    14341 actgttgata gaattaggat tatggaacag taaagatatt cctgtagaaa aatactcaaa
    14401 gggaatgaaa cagcgtttac agattgcaaa gggtctaata aatgatccag agtatttatt
    14461 cctagatgaa ccaactcttg gtttagacgt gagtgtcgct catgaattac gtaaaaaatt
    14521 aaaggaaata gcgattaagc ggaatacggg tattttatta actacacatt atatggctga
    14581 ggcagaagaa ctctgtgatt atatctattt tttaaagaaa ggtaaaatca tcatttctgg
    14641 tactaaagac gaagtttttg acaaattaga attagcccca gagatacata ttacacttgc
    14701 acctcaattt caatggaatt caatggagat taaacggttg agagatttat ttccagaatt
    14761 agagtatagg aaagaagaaa atcttacatt gataaaattt tcgttactaa aatataaagt
    14821 tcaaagtgta ataaagacta tatacgaaag gaatatagat attattgaaa taaaacacac
    14881 ggagccttca ctagaagatg tagttctgca tttagagagg agatgagttg ctttgttttt
    14941 ttaacatatt taggagtgaa atgagaagaa ccctcttcaa tgatagtacc aatatttttt
    15001 attttttttc aatgatatta tggccaattt tttcgctact ccaggtttat tataatatag
    15061 gagcatttcc gatttcagat ttaaaaattt tggacttaag taatgaggag cagctatttt
    15121 attttatttt tataggatac tgtacctata ttattttttc taatgctttt cagagtgctt
    15181 ggagactggg gggagaacgt tatcagggga ctctaagtca gatttttatt gctccactga
    15241 aaaaaattct atggctttac gcccggacat tttcatcgat ttttagtcag tcatggtttt
    15301 ttatggttat ttttgtaatt ggtaattttg cttatataga tttttcatta aaatcgatct
    15361 ttcatatttt attagcaacc attattttaa ttacttcatc atggatttgg actagctttt
    15421 tgagtagtat ttgcattgtt atgagagatg ctactatagt ttatgtatta ttagaaggct
    15481 cacaagatac gtttagcggt gctaaagtcc ctttatctat ttctccaaaa ttggtaaaat
    15541 ttattggaag tttatttcca gttagctata ctattattta tttacgagat atgcttcttt
    15601 tcaataaatt ttatagttta aatttttatt tgctcatcgg tataaatatt gtttgttttt
    15661 tactgactaa tatcatttta agaattggtg aatctcacat gaagaagcat ggaagttttg
    15721 atgtggttta atttggtgtt aataatgtta gatattgcag aagggacatt acaatagtga
    15781 gtaaattatg gggtagatgt aggtacagga agtgaattta atgttattaa ggaagtaacg
    15841 tttgatgatg cattgcctaa attaattgtt aaagttagag attttattcg aacccagcta
    15901 cgagagtttc agtatctaga tagtgatggt agatttcaga tacttccaga atatcctgaa
    15961 tttgcctggt ttgaaggaat tgtaaatgca gtaacccaca ggaattattc agtatacgga
    16021 gatcatatca gggtattgat gtttgataat cgtttagaga ttcatagccc aggaaaacta
    16081 ccgaatattg taactgttga gaatataaga catgaacgtt tttctagaaa tccgcgtatc
    16141 gctcgtacct taactgaatt tggatgggtc cgagaaatga atgagggagt aaaacgaatc
    16201 tattctgaaa tggaatctgc ttttctccat gaaccgtgtt actctgaacc aggtaacaaa
    16261 gtagttttaa cattagaaaa cagtattaca agtagaacat tgagaacgcg tgattctttg
    16321 gaaagtaaac ttagagatta tagtgattta agtgttgatg aaaaactatt gatacagtat
    16381 atgtacaata cagcagaacc tatgacaact aaaaaagtag cagagttctt aggtaggagt
    16441 gtttcttact cgtccaaatt attgaaaaca aaaggcattt taacatggta tgggacaagt
    16501 acgaaagatc gcagtcaata ctataaatta gaaatgaaat aaaaaagaag aaaaacgaag
    16561 aaaacatagt tactaattag tgaatttaaa agtaagctta cttttaaatt cataaaattt
    16621 atttgcttta tagttttgca attcaattgt ttgtatggga atgtgatttt tattatacat
    16681 cattttacaa caagtaacga aacgaagaaa aacgaagaaa aacgaagaaa aataaatcgt
    16741 tgtttctcaa ctacataagc tccgaaaact aaaagtgata accctttgat aacctctcaa
    16801 tttttaaaag ggttatatat gtaaagattg aggatttatc tcttaaaatt acttgatttt
    16861 agtgataatt taccataaat atcatgatgt agaaaaaacc aggtcttaag aaagctcgta
    16921 aagctagcca gttctctaaa cgttaagaat cagctacaat acagcattta caacacttca
    16981 tggttcacac catggggtgt ttttttgatg atttttagca aaattcacac catttttcac
    17041 accaaattca caccattact ttttaagatt gcgataagca atctctccaa cagccattgg
    17101 aatgatattc gaagtattga cataagtctt tgttgtaatc gtgtcactat gggttagagc
    17161 ctcagatata gcttcaatag atgttccagc ctgttttgct aatgttgccc ctgtatgtcg
    17221 taatttatga ggtgtagcat gcttaagttc aggatgacga cgtttgacag atttcatttt
    17281 attattaaga tagtcagagt gtagagggct attaacatta cccttcatat cgatataagt
    17341 aaagacatac tgttcattgg attggataat tccaaatttt gctagttcat ctttttgctg
    17401 ttttttccat tctttaagta agttagtcaa ttcaatggga attcggaaag ttgtcttttt
    17461 attccctttg gtagactttg gatttttgta tttatccaaa gcttgtacta actgaatttc
    17521 ctgatcactt gtattgatat gcttccattg taaagcgtag ctctctgatt ttctatctcc
    17581 caagaaaaag gtggtataaa acaaaacata gtctttgaat agaatttttc cagtatctaa
    17641 atccttttca aaagctgtaa accatgcttg aagttcttct tgagataggt ataaatcttc
    17701 atctttttta gattcttgca acttgatttt cttagtggct ttgatacgac ttattgtttt
    17761 agataggcgg tttgtttcga tgtattctaa ttcttccgcc cagtcaaaga tagaattaac
    17821 gtagctcctg ataactttga aatttgcata ttcttcagcc ttttgagtta atagatttaa
    17881 aacaacttgt ttattttgat tgagaaactc aatagagtag ttaccaagca taggtaagat
    17941 atgttttcta aaggcaattt ctgtaccagt tatggtagct tgagaaggtg gcttagttgt
    18001 agaagtggtt tgtcctgctt tgtaggattc ccaccaaacg tttttataga agtcggaaaa
    18061 gagtatagaa ccattatttt ctagtaaggc tgattctcca ctaataattt tgtcaatctt
    18121 gttttgaagt tctagttcgt atttttttgc ttcactcctt gttttgaacc gtttttcaat
    18181 cactttctta tcaacaccta gtgaagactt aacttcctca ggaatataga ttcgtaagcg
    18241 ataagttcca tttttagttt ttgtaattga catagtattc tcctttttaa ttgagctaga
    18301 aaaataccgt gatttcatta taacaaacca cggtagaaat gctactgatt ttgtaaccag
    18361 cgattgattt ctgctttatc aaaacgaata gtttttccaa ctctaatgta aggtaatcct
    18421 tttttaatcc aactgtcgag agtattgttt gagataccca agtagtggca agtctgttgt
    18481 ttgtttaaaa acggactgtc aaggttacta ttgtttaatc tattttcaat ttctttcttg
    18541 ataagttcag caagtaggag ctgaatttgt tgaacttgtt catctggtag aattacttgc
    18601 atctgttcct ccaatgtatg gtataataga ggtatcaaga gataccctac ttacttttct
    18661 tgattatctg caacctcgtc ctcgctcgcc aaagtttcgg atggggtttt tgatttgcct
    18721 aattctaaga tatcccactg attattaatc gctattttag aaagcaatgt tgataataaa
    18781 tcctgtctac tattaagtaa cgaatcattt gcaaagtcat aagataagga aacttcctgc
    18841 tcattttcta agatagtttt tacaggttct tccattcgtt gaggatatga tacataaaac
    18901 ttaggatttt tatcatttcc tcttattcta gccagacact caattcttct aacatactgt
    18961 gataggtctt ctctatcgtt cccttttgtg ttgtaaaaga aatctagtgg gtatttcgaa
    19021 ctggtgataa tgataacttt tgctgctccc atcttatttt gatagcgtgc agaaattggg
    19081 cttatgttga aggggtctaa tagttttagc caatctgacg cggttaaact atctcctcga
    19141 acgtcgtcaa gaaaaaggat ctcttctccg tttacctcgt caaagatgtt tgtggcagca
    19201 gtcactactg attgccagtt ttgaccattt aattttgcca actgaatgat ggctttggat
    19261 aagtcctttg caaaggttga ctttccaaga ccagtactac catgaatgaa gagaatggtt
    19321 tttttaaatt ctccgttatc taactcatat ttagtacgag ttcctttgat ttctccgacg
    19381 gtacgaaatg tatcgtttat cctagctttg tggactgcgt acagtgtacg atatttctgt
    19441 tcaagaagta tttcattttt ggtgatatac tcgtttagaa tgttatcgat aagtaagtca
    19501 atatcttcgt aggtttggtt tacctctttt ttggcttttc ctttaagcca gatttctttc
    19561 cttttgtgat atacttctaa gtagtcttta cctgctagag taactacttc atcagggcta
    19621 tattgatatt tatctttatc ttttgcatga attaagtatg ctaacaagtt atcgtaacca
    19681 tatcttccag actttgattt ttcgagatac tcttctgcta atccgattat ttccgctaaa
    19741 gtagatagtg ttgcaccttt gcatttttta aacttgagta aagcatgaat gtgtggttgg
    19801 gcaagttcag tagttgtttc ttgaagttct ttgtcgaata ctacagatgt gtccttatca
    19861 tgcttaattg catatgcttc agtaacagtt gctatttcac taactcttct gactatttct
    19921 tcaagaattt tttcgatatt ttcggactta atgagttctt catcccaacc attcttccaa
    19981 taagtcgaat caaaatattg tgtaattgct atagaagtca aaagcgcttc cttcttcttt
    20041 gaagtcattt atattaaacc tttctttttt aactattctt taattattct tttaattatt
    20101 atagtgttag actatcgaca agcccagtct aacacgcgtt agaaataatt aaaattaaat
    20161 tcagatactc ttggggcttt gccccaagcc ccagcctccc ctgcccgatg atgaatcatc
    20221 gaaccgagaa cgcttgccag ctaacaaggg acgggtagta t
//
