LOCUS       NZ_CP053892            22595 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9840041
            Orig. end                         :: 9862636
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..22595
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="34"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22595
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22595
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12595](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12595
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    146..160
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.26"
                     /tool="antismash"
     misc_feature    complement(308..322)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.54"
                     /tool="antismash"
     gene            complement(1161..1331)
                     /locus_tag="ACTIVE_RS47020"
                     /old_locus_tag="ACTIVE_8918"
     CDS             complement(1161..1331)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS47020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_8918"
                     /product="hypothetical protein"
                     /protein_id="WP_216858173.1"
                     /transl_table=11
                     /translation="MLYDRGGDRRPEMIVTEASTRADYGPFTDAARGRIDLARIEVSAI
                     LPLLDPVPRKG"
     misc_feature    complement(1194..1196)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    1826..1841
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.98"
                     /tool="antismash"
     gene            1869..2675
                     /locus_tag="ACTIVE_RS44495"
                     /old_locus_tag="ACTIVE_8919"
     CDS             1869..2675
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653239.1"
                     /locus_tag="ACTIVE_RS44495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8919"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_216858174.1"
                     /transl_table=11
                     /translation="MNDYFLNEADLTDRMERNLAEHACHLHRSMSGATIAETGDLLVAD
                     SGLDDDTFNIVAAARFTVADAAARIAETVGTLAGTGRSFSWWVGPASTPTDLTARLTAA
                     GLPVFERETAMWAELDDTLPTPSVPGLVIRTATTPEQLADYTKVLAANWTPPAETVRDF
                     FARAASQALAATCPARYLVGYVENSPVCSAEVFHHAGVAGIYNISTLAPHRRRGYGGAI
                     TLAALGAARERDHRIAVLQASTDGEPVYRRLGFRACGEFVEHAINT"
     gene            2981..3220
                     /locus_tag="ACTIVE_RS44505"
                     /old_locus_tag="ACTIVE_8921"
     CDS             2981..3220
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025428.4"
                     /locus_tag="ACTIVE_RS44505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8921"
                     /product="DUF4253 domain-containing protein"
                     /protein_id="WP_173100576.1"
                     /transl_table=11
                     /translation="MDRDHSQLKIRFRYTPEQERYGMRVCCLGRAGLNITVAWPPRLLE
                     HARRVAAEHHAFCPDLRSVTSRRRWRMRCSQGVG"
     gene            3313..4917
                     /locus_tag="ACTIVE_RS44510"
                     /old_locus_tag="ACTIVE_8922"
     CDS             3313..4917
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013132206.1"
                     /locus_tag="ACTIVE_RS44510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8922"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_173100577.1"
                     /transl_table=11
                     /translation="MITVRGVELRAGARLLLCDISFSVSPGDRIGLVGRNGAGKTTLMT
                     ALAGQARPAAGTITHTGPVGLLAQDSRTADPAVTVTDRILSARGLDRALHAMRAAETAM
                     ADAAGPVALERAMNAYARAETALQAGGGYAAEGEAARIAAGLGLPERVLGEPVGALSGG
                     QKRRVELARILFAGHGGTLLLDEPTNHLDADSVAWLRTFLQSHQGGLVVISHDTALLAD
                     VVNRVFHLDPQRTTIDIHNTGWNTYLTQRETDDRRRARERANAERKATALHAQADKMKA
                     RSATAVMARSMARRADRMLAELEPARRAEKVARIRLPEPAACGRMPLGAVSLSKSYGAH
                     QVLDRVDLAVDRGSRLLILGLNGAGKTTLLRLLAGQEPPDAGRVVHGHGLRLGYFAQEH
                     DTLRAERTVGENLRAAAPHLTDGEARRVLGAFLFSGDDADKPAGVLSGGEKTRLALAGL
                     VHSGANVLLLDEPTNNLDPASRAEVLAAVGSYPGAIVMVTHDEDAIDALRPDRVLLLPD
                     ADEDLWNEDYRDLVSLA"
     gene            5121..5570
                     /locus_tag="ACTIVE_RS44515"
                     /old_locus_tag="ACTIVE_8923"
     CDS             5121..5570
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS44515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_8923"
                     /product="hypothetical protein"
                     /protein_id="WP_173100578.1"
                     /transl_table=11
                     /translation="MTAAGAHPITDPVAAWRDWTALLAARGIAGGRLLRSVDRHGRIGD
                     RITGDAINRAVRRLAVAAGVPDADSFTAHSLRAGGATVAYTSGVPVSDRPARPVGTRLP
                     GAAGLHPRTGPLARQRHAQRRAVGRDRLQRPGGQAARGCGCSASR"
     gene            complement(5539..6066)
                     /locus_tag="ACTIVE_RS44520"
                     /old_locus_tag="ACTIVE_8924"
     CDS             complement(5539..6066)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS44520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_8924"
                     /product="hypothetical protein"
                     /protein_id="WP_173100579.1"
                     /transl_table=11
                     /translation="MSITVDTADPSPLGTADPRDLVPADLFGRLAARISRDHAVEAPMA
                     ERIMSQALAFLAACARHRGAGLTPSSQVDIGWHTFLLYTAEYAQFCARVAGGFIHHRPD
                     DDELGAMSSPAGRADRIAATLAAIQAAGMPVDTELWDPARGGDGATRKSDCQAEGACRT
                     EAVIGSHCSRTL"
     misc_feature    6190..6203
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.15"
                     /tool="antismash"
     gene            6411..6602
                     /locus_tag="ACTIVE_RS44525"
                     /old_locus_tag="ACTIVE_8925"
     CDS             6411..6602
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS44525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_8925"
                     /product="hypothetical protein"
                     /protein_id="WP_173100580.1"
                     /transl_table=11
                     /translation="MPDAEAHTAHSLRTGGATVAYTSGVPVSVIARHGRWAPASPVLLG
                     YIRALDRWRDNAMRNVGL"
     misc_feature    7033..7048
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     misc_feature    complement(7085..7099)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    complement(7245..7259)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.1"
                     /tool="antismash"
     misc_feature    complement(7319..7336)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.7"
                     /tool="antismash"
     gene            7353..8015
                     /locus_tag="ACTIVE_RS48000"
     CDS             7353..8015
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF026010.4"
                     /locus_tag="ACTIVE_RS48000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_246342566.1"
                     /transl_table=11
                     /translation="MTLGYAFKRIDRHGKARYTACYEDLKGKITSAGTFSSKKEADRAW
                     QRAEAEVGKGRDLNLKRGRQTFKKYVEETWLPNHEVEPSTMQSYHYSIYKHVMPEFGAM
                     RMMDILPEHVRAWISGMKKNGVSAATIRYNKVVLSAIFTTALNDQVTYIHPCKGVRTPT
                     VPEKPLEIISPEQFDDLYHALPDADSKLLVETAIETGLRWANSPNSAVATSRPAPAS"
     gene            8033..8698
                     /locus_tag="ACTIVE_RS48005"
     CDS             8033..8698
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012798.4"
                     /locus_tag="ACTIVE_RS48005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_246342567.1"
                     /transl_table=11
                     /translation="MELNPKFHPEGKRFLVKDYPKDKEWRRFKLSDQIVTKLEDHIIEE
                     GLGTDGLLFVYLPETANEEPPAPLDPEVLGWTEENAKGRRYRHGTLSAYNAAKCRCEHC
                     RRAFAEYRARRRADGKDSPREPRRRETDGHVPANWFRNRIWKPALKKADLDPKVRIHDL
                     RHAHASWLLAGGADLQVVKERLGHGSISTTERYLHTPDDADDTALAAFDKIRSRRRTD"
     misc_feature    9410..9423
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.36"
                     /tool="antismash"
     misc_feature    complement(9411..9425)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.46"
                     /tool="antismash"
     misc_feature    complement(9573..9586)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.61"
                     /tool="antismash"
     misc_feature    complement(9600..9613)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.22"
                     /tool="antismash"
     gene            9664..9867
                     /locus_tag="ACTIVE_RS44535"
                     /old_locus_tag="ACTIVE_8930"
     CDS             9664..9867
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS44535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_8930"
                     /product="hypothetical protein"
                     /protein_id="WP_173100581.1"
                     /transl_table=11
                     /translation="MNALLVGPRDAGPSTADLDIGFFDSDEEVAAHGPQACAPTCNSGL
                     TFVCDGDSAHTCSSGRTFICDG"
     gene            10001..12595
                     /gene="lanL"
                     /locus_tag="ACTIVE_RS44540"
                     /old_locus_tag="ACTIVE_8931"
     CDS             10001..12595
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="ACTIVE_RS44540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8931"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_246342568.1"
                     /sec_met_domain="Pkinase (E-value: 1.8e-17, bitscore: 62.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.7e-18, bitscore:
                     64.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGEFGWRTRAGRVWVHCDPPSVSLPEQGWKIHVSARPATLPETL
                     RVVVPLLVRRGCAFKVVNGREALAELNAPDDRVSSVGKAITAYPSPELFRELAVELAEA
                     LRGFAAPVVRSDRRVHPEAPVYYRYGPFAARYRVSLNGQPELVVTGPDGEEYPGAAGRF
                     FGCPPWERDPLSADQGPPPDDGEGPPPDADEVTPVGKGAPVGDGDPGVVLGGRWRLQEG
                     VQNRSRGRIFRGRDVVTGREVVVKEARAYIGGETADSDCRANLRSERRVLAALDGVTGV
                     PQVLDHFRHGEDEFLVLSSMGRRNLADDVATSGIYPDRPGERDLSVLARELLVLLDAVH
                     ERGVVVRDLSPKNVVLDEAGGCHLIDFELARLDGRQRPGYSRGYCSPEQLRGEPGTVAD
                     DHFAVGMTLFYAATGIDPVMIHRDALRDAEQSLAVLAGAFPDGGPTLARIPGLVSADPA
                     ERIAAVGALRAGDSGRFTGWSHHPAEVDTGTVARVLTHTLAQTVRHGKELLTSDSPSGP
                     MRLDVWQGAAGLGTELLHHLTDGTAQALAADLARNTAEHPLLNAYPQGLAFGRTGIAVF
                     LAAAGRRLDDDDLRGAARRAAPPDPGLLARVEYSDYAQGLAGIGAGHLMLAELTGDGAH
                     LAVAAECARRIADGECLTSADDTADPTNGIVIGLGHAHGRAGLGAFLLAYHTVTGDRRA
                     EAAAHVQYAVLCERLPQVLAAAARPSARPMCASWCQGLSGIGTSLLRAAALGDDRCLRL
                     AQDAAETSLLMAPRMGIVTQCCGMAGVGELLVDLGAATGQNTWFGEAERVLGLMLDRCG
                     GEPDTPAEFPDNSLRGGSGGWATGSAGILTLLRRVRDRGGAGPWTFGQWTAA"
     gene            12592..14529
                     /locus_tag="ACTIVE_RS44545"
                     /old_locus_tag="ACTIVE_8932"
     CDS             12592..14529
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="ACTIVE_RS44545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8932"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_173100583.1"
                     /transl_table=11
                     /translation="MTTGTARPRTEERCAAGIDEQAVFGGRPQAVKTGSLAMLRELPGA
                     IGQTIGLLWTAGRGLTVTVLACQTAAAALTGLGLLAGTRVLAALLAGGPTPQRITAALP
                     SLALVGGVLAARGALTAAVAEAQSRLTPRVLRHAHDRLYEATAAVELAAFDDPDWQEAL
                     SRARQRTLPAIELAVAELLAVAAAIAGLLAVGGILATLHPLLLVLLTASVIPHTWAAMR
                     AARTAYTGEIPLAALYHRQQLIADLITGRPAAAEIRAYGAERFLLAEYRRWAEAVQNQR
                     QRLELTRARTTMAGRTLGGIGVLITLIALGALLNAGVMPLAAAATAVMAIRAGQASFVQ
                     LATTANRLYERGLYIGDFNRFLADSHARAHHPTGDPMPRDFAAIHLDDVTFCYPGTEKP
                     AVEGVDLSLVQGEVIALVGENGSGKTTLARLLAGLYRPTAGTIAWGGPSPRVLAPGDLR
                     RLVGLLGQEPVRWPLSAHDNITLGRPAPRPSALDRALSEAGADQVLAGLPHGAETLLSR
                     HLHGGTDLSGGQWQRLALARALYGAPSILICDEPTAPLDARAEQRAYDTIRRQAAQHGT
                     TVVLITHRLASVRHADKIYVLDHGHLIEHGTHDELLARNGDYAQLYRLQAAAHAPPTPH
                     RRETPDPARP"
     misc_feature    12898..12900
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14956..15120
                     /locus_tag="ACTIVE_RS47025"
     CDS             14956..15120
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS47025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216858177.1"
                     /transl_table=11
                     /translation="MTGEARPAALRQLVLQAPAPVIARSLGFHDNSTTRIAAEAGGSWN
                     RYAPGDHTK"
     gene            15302..15700
                     /locus_tag="ACTIVE_RS44555"
                     /old_locus_tag="ACTIVE_8934"
     CDS             15302..15700
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS44555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_8934"
                     /product="hypothetical protein"
                     /protein_id="WP_173100584.1"
                     /transl_table=11
                     /translation="MTEPDWEGRLAGPAAMGRLVSRAFEDRLHGRGLPRARVDLLCVSA
                     DVLAAAELAGMRPSPADQALRSVLGVMAAAWEQAMTAHGMLRGTIDACRREVGREVEEL
                     LDEHARLVRGRRAADRPVPCPPAEAEGM"
     misc_feature    complement(15816..15830)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.13"
                     /tool="antismash"
     misc_feature    complement(15842..15858)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.12"
                     /tool="antismash"
     misc_feature    17768..17778
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            18188..20494
                     /locus_tag="ACTIVE_RS44560"
                     /old_locus_tag="ACTIVE_8938"
     CDS             18188..20494
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024793.4"
                     /locus_tag="ACTIVE_RS44560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8938"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_173100585.1"
                     /transl_table=11
                     /translation="MTRWQWARVGVRHEPTGFIGRKAELEAVRESVSRSRVVTLTGPGG
                     VGKTRIALRAAHQLGAEFPDGVAIAELSGLRDAELLPNTVASAVGLPEVAAQQPMDQLL
                     DHFAGKRALLVLDTCEHLVDAVAVFADILVHGSAGLVLLLTSRQPVALPGEFVLPVEPL
                     PEPGAEASESTNDAVALLVARAQAACPSFTLSDDNRAEVVALCRRVDCMPLAIELAAVR
                     LRTLSLEQILRRLDDRFQLLTGARSAQTRHQALRTTIEWSHDLCSPQEQQLWSRLSVFA
                     GGFTLAAVEEVCAGGDLDGFDVIDLLLGLMDKSVVQRVNGVDEDRYRLLDALREFGAER
                     LARDGTTAVYARRHLEFFLQMADQADRQWMGDQQTQWSERLAADLDNFRVALEHAIADP
                     QDEAALRLVNGLSGLWQGKSRLTEARRWLDRAIAAAAEPTFEQGKALWSASYYGLLQAD
                     PAVTETVRRLRAVAEHLQDEFLRARASTAEAYEQLLWVDTRAALKQYEPVRAALAATGD
                     RFTLIISYPQTAAGYNAVGDPHRALQEVEAGLRELESIPQERWARNHLLSMKVLCLCAM
                     GELDAGRDLGRSILPSIVEQGETMCVAAVTEYLSWAACGNGEHDQAATLLGASVTLWRK
                     VGALLWGAPGLIRRHTDVENALMIDLGADRFTQAYARGTGLSMPELLQTVAPASAAPPP
                     PAPPVEDRGPLGALTERERQVAHLITEGLTNRQIAERLVISKRTADAHVEHILAKLGFN
                     SRTQVATMIATHKQD"
     misc_feature    complement(20732..20746)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.69"
                     /tool="antismash"
     misc_feature    20733..20747
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.16"
                     /tool="antismash"
     gene            20785..21240
                     /locus_tag="ACTIVE_RS44565"
                     /old_locus_tag="ACTIVE_8939"
     CDS             20785..21240
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011292157.1"
                     /locus_tag="ACTIVE_RS44565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8939"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_173100586.1"
                     /transl_table=11
                     /translation="MWRELIGRLYSDAEFAAPAPDEEIDQIEQRLGQRVPDELRELLRE
                     TSGVQDEYGSGLVWSVQEIIEQNTEFRQSADFAELYASFDQLMFIGDNGGGDQFAFVQA
                     PGERLGDVVVWDHETDERTWVARSLKDYLESRAASDGDDWYKQGSGQ"
     gene            complement(21245..>21583)
                     /locus_tag="ACTIVE_RS44570"
                     /old_locus_tag="ACTIVE_8940"
                     /pseudo=""
     CDS             complement(21245..>21583)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558180.1"
                     /locus_tag="ACTIVE_RS44570"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="ACTIVE_8940"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LGRSRGGLTTKVHLSAEQGQRPLSLVVTAGQRGDSAQFKPVLEGI
                     RVPHRSGGLPRTRPGRVRADKADYRERHAAECAINRLKRNRAVATRYDKLAVRYEATLH
                     IACINEWL"
     gene            complement(22135..22443)
                     /locus_tag="ACTIVE_RS44575"
                     /old_locus_tag="ACTIVE_8942"
     CDS             complement(22135..22443)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS44575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_8942"
                     /product="hypothetical protein"
                     /protein_id="WP_173100587.1"
                     /transl_table=11
                     /translation="MTGELYDWNVHSRDGRRAGPGGVNSDRQQAIADLTDALGQAQPGS
                     WGMVWSVRLHLTRTFEYHCDGLVAVGLRDRRSGAVTVDGPPSASPAGNTPEHDAPNW"
ORIGIN
        1 gcggagcgcg acttcccgtt ccgctccagc atcagcaccc agcccgcgcc gatgacggtc
       61 tccaaggact ccaacacgcc gacaaaggcg tccttggacc ttctgatctc caacgacggc
      121 ttctcccaca tcgacatcga atccctgacg atcacgttca ccgtcgccga cgacaactgg
      181 ggccaggacg cctccggcat cctcaccccc gtatggaaca aggtcagccg accgaagcca
      241 gaactgcccc ccggctgggc cgaggacacc agcagcccgg aaccgggcca gttcaccttc
      301 aagcccgaga acaagaaggt caagccgaat gacgcgctgc gcctgcacct cgacgacatc
      361 cacgtcagcg ccatcgaggg catcaccgac gtcgtcgtct ccgtcgaggt ccccgatggc
      421 caaccggaat tcaaggacgc cacccattcg atcggaaaat tccccatcgg cttcgaaatg
      481 aaggactttc gcgccgatga cccgatcgtg gaaaacggcc agtcgactaa actcaactgg
      541 aaggtcggcg gcgacgacaa cgtcgtctat aatttcttcg tcaacggcgt cgagaaagaa
      601 ctcagaagcg gaaggatcga gccacctttc gacaccggcc ccctgcacgc cacaacggtc
      661 tacaagatca ccgctaagca gcaggtcggc ggcgactggc ttctctactc cgactcgacc
      721 gtcgtccacg tccacggcgg cgagatcacc gccgccaacg cactcattgc cgggctgcgg
      781 cccgcgctcc tcaagacttt gctctcttat cacagcttcg aagtgatagg tgcgggtacc
      841 gaagaatcga agtacagatg tacgggctcc gccgacggtc tgatcgtggg cgaattgaag
      901 atcaccgggg aagggaaagc ggaagcggaa ctcgcagtgc ggcttacctg cgagggattc
      961 ccccctgtcg aggcaaaggc gccggcaggc ggtaatgacc tctacttcgg gcagtacatc
     1021 atcatgccgc ttcccggcgg ggaagtctgc gaggtgcaag tcaaggcaaa gaacgtcgaa
     1081 accaccacag gttgggtcaa tctccactgg gtcagcctgt ccggagacaa ccggagcccg
     1141 aagtgcgaac aggtgccggt ttaacccttt cgcggcacgg gatcgagcag gggtaagatc
     1201 gccgaaacct cgatccgggc caggtcgata cggccgcggg cggcgtcggt gaacgggccg
     1261 tagtcggcgc gggtagaggc ctcggtgacg atcatctcgg gacggcggtc gccgccgcgg
     1321 tcgtacagca tgtccaggac gtgcagcgag tcgcgcgggg gccgatcacg atcttgccgc
     1381 ccagccgggc ggcctggtcg ttgatcatgt tgagccaggt cgcgccgcag cggcggccga
     1441 agtacttggg gctggcgatc cgagcgaagt cccacccgct atttgatctt gaagtgccgt
     1501 catgacggca cggcggcggc ctcgggcacg gcaggcccgg gaagcgggcg cggcctggca
     1561 tgcccgaggc cgccgtggtc cctgtccggt ggcggacgct cttgccgcaa cggcgtaacc
     1621 tgcgcgctca cctgtgcagc cgccacatcg ccgctgggag tgccaccgga accgtggact
     1681 cgcattcgtc accgtgctgc cgtacttcgg cgcccaggcc gacgagcacg cgccgggcgt
     1741 caggtgtgca aaatgccgct gccgggcagc acggcccgct agggcgtgta tcgaaagtgc
     1801 tggtcgtcgg cgtggccccg cctaaaatga catgcagtct ccgctcggtc ctgctgggat
     1861 caaacgctat gaatgattac tttctcaatg aagccgactt gacggacagg atggagcgga
     1921 atctggcgga gcacgcctgc catctgcacc gaagtatgtc cggtgcgacc atcgcagaga
     1981 ccggcgacct cctggtcgcg gacagcggtc tggacgacga cacgttcaac atcgtcgccg
     2041 cggcccgctt caccgtcgcc gacgccgcgg cccgcatcgc cgagaccgtc gggacgctgg
     2101 ccggcaccgg ccgcagtttc tcctggtggg tgggacccgc ctcgacaccg acagacctca
     2161 ctgcccgcct gacggcggcc ggcctgccgg tgttcgaacg tgagacggcg atgtgggccg
     2221 aactggacga caccctgccg actccctctg tcccgggtct ggtcatccga accgcgacca
     2281 cgcccgagca gctcgccgac tacaccaagg tcctcgccgc gaactggact ccacccgctg
     2341 aaacagtccg cgacttcttc gcccgggccg cttcccaggc gctggccgcg acctgcccgg
     2401 cccggtacct ggtgggctac gtggagaaca gtccggtctg ctccgccgag gtgttccacc
     2461 acgcgggagt cgccggcatc tacaacatct ccaccttggc cccccatcgc cgacgcggct
     2521 acggcggagc catcacgctc gcggcccttg gcgcggcccg cgagcgagac caccgcatcg
     2581 cggtcctgca ggcgtcgacc gacggcgagc ccgtctaccg ccgtctgggg ttccgcgcct
     2641 gtggcgagtt cgtcgaacat gccatcaaca cctgaaccgc tcagacgtcc acggacgttc
     2701 gtcatctctg attgagctgg tcacagccat tcattgatgg ccgctacgag gacagcggcc
     2761 tcgtagcggc ccgcgagttc gtcgtatctc gtggccacgg cccggttcct tttgaggcgg
     2821 ttgatgccgc actcgacggc atgccgggcc tttgtgcgcc ttgtccgcac ggacccggtt
     2881 ggggcggacg cgttgcactg ccaccggcgg aacaggtcgt agacgcggct ccatggtccc
     2941 cagcagtgcc caccgctcgt ccgtgagatc tcctcgtccc atggaccgtg atcattcaca
     3001 gctcaagatc cgttttcgat acacgcccga gcaggagcgg tacggcatgc gcgtctgctg
     3061 ccttggccgc gccggcctca acatcaccgt cgcctggccg ccccgactcc tcgaacacgc
     3121 ccgccgcgtc gccgccgagc accacgcctt ctgccccgac ctcagatcgg tcacgtcccg
     3181 caggaggtgg cgaatgcgct gctcgcaggg cgtgggttag ggtggatgga tgtccacgcc
     3241 ccgagtttcc tagctgaagg acccgcttcc gcaccagaag tgtgtccctt ggctttctcg
     3301 gagcgttatt ccatgatcac cgttcgcggt gtcgagctgc gcgcgggcgc ccgcctgctg
     3361 ctctgcgaca tctccttctc cgtctctcct ggcgaccgca tcggcctggt cggccgcaac
     3421 ggcgcgggca agaccacctt gatgaccgcc ctcgccgggc aggccaggcc tgccgccggg
     3481 acgatcacgc acaccggccc ggtcggcctg ctggcccagg actcccgcac ggccgacccg
     3541 gccgtcaccg tgaccgaccg gatcctgtcc gcccgcggct tggaccgtgc cctgcacgcg
     3601 atgcgcgcgg ccgagaccgc catggccgac gccgccgggc ccgtcgcgct ggaacgggcg
     3661 atgaacgcct acgcccgcgc cgagaccgcc ctgcaggccg gcggcgggta cgcggccgag
     3721 ggcgaggccg cccggatcgc ggccggtctc gggctgcccg aacgcgtgct gggcgaaccg
     3781 gtcggcgcgc tgtccggcgg ccagaagcgc cgggtggaac tcgcccgcat cctgttcgcc
     3841 gggcacggcg gcacgctgct gctcgacgag ccgaccaacc acctggacgc cgactccgtc
     3901 gcctggctgc gcaccttcct ccagagccac cagggcggcc tggtggtgat cagccacgac
     3961 accgcactgc tcgccgacgt cgtcaaccgc gtcttccacc tcgacccgca gcgcaccacc
     4021 atcgacatcc acaacaccgg ctggaacacc tatctcaccc agcgggagac cgacgatcgc
     4081 cgccgagcac gcgagcgggc caacgccgaa cgcaaggcga cggccctgca cgcacaagcc
     4141 gacaaaatga aggcgcggtc ggctaccgcc gtcatggcca ggagcatggc ccgtcgcgcg
     4201 gaccggatgc tggcggagct ggagccggcc cggcgcgcgg agaaggtcgc caggatccgg
     4261 ttgcccgagc ccgccgcatg cgggcggatg ccgctcggcg ccgtcagcct gtccaagtcc
     4321 tacggcgccc accaggtact ggaccgcgtg gacctggccg tcgaccgggg cagccgcctg
     4381 ctcatcctcg gcctcaacgg cgcgggcaag accaccttgc tgcgcctcct ggccggccag
     4441 gaaccgccgg acgccgggcg ggtggtgcac ggacacggac tgcggctggg ctacttcgcc
     4501 caggaacacg acaccctccg tgccgagcgc accgtagggg agaacctgcg cgccgccgcc
     4561 ccacacctca ccgacggtga agcccggcgc gtgctgggcg cgttcctgtt ctccggcgac
     4621 gacgccgaca aacccgccgg agtcctctcc ggcggcgaga agacccgcct ggctctggcc
     4681 ggcctggtcc actccggcgc caacgtcctg ctgctggacg agccgaccaa caacctcgac
     4741 cccgcctccc gcgccgaggt cctggccgcg gtcggctcct accccggcgc gatcgtcatg
     4801 gtcacccacg acgaggacgc catcgacgcc ttgcgccccg accgcgtcct gctgctgccg
     4861 gacgcggacg aggatctgtg gaacgaggac taccgggacc tggtctccct cgcctgacca
     4921 cgaccgcaca gcccgtgccg caccgggccc ggtggtgaca cagccggtcg agggttgcgt
     4981 caccacccgg ccccgcctga cgggacgagc tgatacgtcg ccgtcaggcc cgcgcatagc
     5041 tcgcctacca gggaggggcc gctcaaagag gtcatctatc cgatctgcgc cgcgggcttc
     5101 tagaacctgt cccgtaaggg ttgaccgccg ccggcgcgca cccgatcacc gaccccgtcg
     5161 cggcctggcg ggactggacg gcgctgctgg ccgcgcgcgg gatcgccggc gggcggttgc
     5221 tgcgcagcgt ggaccggcac ggccggatcg gcgaccgcat caccggcgac gccatcaacc
     5281 gcgccgtgcg ccgcctggcg gtcgccgcgg gcgtgcccga cgccgacagc ttcaccgcgc
     5341 actcgctgcg cgccggcggc gccaccgtcg cctacacctc cggggtcccg gtgtcggatc
     5401 gcccggcacg gccggtgggc acccgcctcc ccggtgctgc tgggctacat ccgcgcactg
     5461 gaccgctggc gcgacaacgc catgcgcaac gtcgggctgt aggtagggac cggctgcagc
     5521 ggccgggcgg gcaggcggct agagggtgcg gctgcagtgc gagccgatga cggcttccgt
     5581 cctgcaggcg ccctcggcct ggcagtcgga cttgcgcgtg gcgccgtcgc caccccgggc
     5641 gggatcccac agttcggtgt ccacgggcat gcccgcagcc tgtatcgcgg cgagggtcgc
     5701 ggcgatgcga tcggcccggc cggccggcga ggacatcgcg ccgagctcgt cgtcgtcggg
     5761 gcgatgatgg atgaaaccgc ccgccacacg ggcgcagaac tgcgcgtact ccgccgtgta
     5821 cagcaggaac gtgtgccagc cgatgtccac ctgcgaggaa ggggtcagcc cggcgccgcg
     5881 gtgacgggca caggcggcca ggaacgccag cgcctggctc atgatgcgtt cggccatcgg
     5941 cgcttcgacg gcgtggtctc ggctgatccg tgccgcgagc ctgccgaaca ggtcggcggg
     6001 gaccaggtcc cgggggtcgg cggtgcccag aggcgaggga tcggcggtgt caacggtgat
     6061 gctcactacg gtgctccttg gagtgtcggg ggcgccaggt ggcctgctgc ccgagaaccg
     6121 accgtcggcc tcgcctcgcc acactgcgtg ccgaggccaa ggcgtcggcg acctcctgtt
     6181 caaccacccg gcatgtactt tgcgttatcg aacaactacc cacagaccag ggcttatgcc
     6241 ggggcaaccc gggccgtcgg cctggcggga ctggacggcg ctgctggccg cgcgcgggat
     6301 cgccggcggg cggttgctgc gcagcgtgga ccggcacggc cggatcggcg accgcatcac
     6361 cggcgacgcc atcaaccgcg ccgtgcgccg cctggccctc gccacccggg atgcccgacg
     6421 ccgaggccca caccgcgcac tccctgcgga ccggcggcgc caccgtcgcc tacacctccg
     6481 gggtcccggt gtcggtcatc gcccggcacg gccgctgggc acccgcctcc ccggtgctgc
     6541 tgggctacat ccgcgcactg gaccgctggc gcgacaacgc catgcgcaac gtcgggctgt
     6601 aaggggtgcc gtgaacggcc cccttactat gaagtcgggc agcgtcgagc ccggtagcac
     6661 tgagtgatgt ggggcatctc gatccggtcc cggcccgcca acgcggcgtg gttcgccagc
     6721 gggatgggct gccactggac gacgttgccg cgcgagcacc agtccgagcg gagctgctgt
     6781 ccgaggtcgt aggagacgat ctcgtcggcg gtgccgacgc tggaactccc aggccgagcg
     6841 gcggaggctc tgcgcaagca tcacgcgcgc caagcctcgc aacgcctcag agcgggagag
     6901 gcacggcagg acagctacct ggtgttctgc tcgacgaccg gaagaccgct ggacgccgcc
     6961 aacgtgcggc gggcgttccg gctcatcacc aagaaggcgg ggatcgggag gcctggtcgc
     7021 cgcgcgaact gcgtcactcg ttcgtctcga tcacgagtga cggtggctcc ccttttggct
     7081 ccccatcgac ctcgaagatc gaaaaagggc tccggagtga tctccgaagc ccctctgacc
     7141 tggcctttct ctgtcgggac ggcgggattt gaacccacga ccccttgacc cccagtgccc
     7201 taaaagcatt catcctgcct ccttcgtgat cagttgaatc cgtgagaaca tgcaggtcag
     7261 aggcttaaag tgcgtgacgt gcagtcatcg tggatgtcgc ccctgggggc agagtccgct
     7321 aacgagccac taacaaacga tcattcgggg gagtgacgtt ggggtacgcg ttcaagcgga
     7381 tcgaccggca cggcaaggcg cgctacaccg cctgctacga agacctcaaa ggcaagatca
     7441 cgtcggcggg gaccttctcc tccaagaagg aggccgaccg ggcctggcag cgcgccgagg
     7501 ccgaggtcgg caagggcagg gacctcaacc tcaagcgagg acggcagacc ttcaagaagt
     7561 acgtcgagga gacgtggctg cccaaccacg aggtcgagcc gagcaccatg cagagctacc
     7621 actactcgat ctacaagcac gtgatgcccg agttcggtgc gatgcggatg atggacatcc
     7681 tccctgagca cgtccgtgcc tggatcagcg gcatgaagaa gaacggcgtc tccgccgcga
     7741 ccatccgcta caacaaggtc gtcctcagcg ccatcttcac caccgcactg aacgaccagg
     7801 tgacctacat ccacccctgc aaaggagtcc gcacccccac cgtccccgag aagccgctgg
     7861 aaatcatcag ccccgagcag tttgacgact tgtaccacgc cctcccggat gccgactcca
     7921 aactcctggt cgaaaccgcc atcgaaaccg gcctgcgctg ggcgaactcg ccgaactccg
     7981 cggtcgcgac ctcaagaccc gctcccgcct cctgacggtc agccgcgtcg tcgtggaact
     8041 caacccgaag ttccaccccg agggcaaacg cttcctggtc aaggactacc ccaaagacaa
     8101 ggagtggcgt cgcttcaagc tcagcgacca gatcgtcacc aaactcgaag accacatcat
     8161 cgaagaggga ctcggcaccg acgggctcct gttcgtctac ctgccggaaa ccgcgaacga
     8221 ggagccaccc gccccgctcg accccgaagt actcggctgg accgaagaga acgccaaggg
     8281 gcgccgatac cggcacggca cgctgagcgc ctacaacgcc gccaagtgcc gctgcgagca
     8341 ctgcaggcga gccttcgccg aataccgcgc tcgccgccgc gccgacggca aggacagccc
     8401 ccgcgaaccc cgccgacgcg agaccgacgg ccacgttccc gcgaactggt tccgcaaccg
     8461 gatctggaag ccagccctca agaaggccga cctggacccc aaggttcgca tccatgacct
     8521 ccgccacgcc cacgcatcct ggctactggc cggcggcgcc gacctccaag tcgtcaaaga
     8581 acgcctcggc cacggatcca tctccaccac cgagcgctac ctccacaccc ccgacgacgc
     8641 cgacgacacc gccctcgccg ccttcgacaa aatccgcagc cgccgccgca ccgactgacg
     8701 aactgagcgt tctgctcgaa gcgggccgaa caaggagacg tcaagcggaa gcaatcgtcc
     8761 gccatgcctg tgtcatcctg cgacgatgct gggttgcgca acctccggat taaaagtccg
     8821 aaactgttgt atcaacgcgg cgctctcggt gtcattctat gccggcctgt ccgtatcgag
     8881 cccgatttct gtgccgtccc atggcgccgt gtgcagatcc gtttcggaac cgccgagccg
     8941 acaacgagcc gacatggccg ctgacgatct tacggcctct tcgccagcga ccttttccaa
     9001 tctgcacgta tgaattttcg gcatgtgcaa gggcgcgccg gcgagtgacg gggcgagtgt
     9061 ggcgaaagcg accaccgcag ccccaactcg gcgagtgagg tgggcattta ttagggcgtc
     9121 tggacacccc cgtgatcagt ctccagctgc cgggctggct caatgacccg cagtttcgca
     9181 ccgctgggaa ggtaattcct agttcgcggt gatccgctgg cacctgggcg gtcggcaaga
     9241 ccaggaacgc gcggcctgac gccgggacgg gacgcggtcc ggccggcggt gcaggctgat
     9301 caggaccttg gtggctgcgc ccccaccgac gtttggccgg gttgcttcgg gtagccggcc
     9361 gtcccatgcg gacttcccga tcgggttcgc ggcagcgggt gacgcggcga atttgagaga
     9421 aaagtgatga acaccccagg tgccgacctt tccttatatt ggaggttcgg tgcggtgtgt
     9481 gacggtgagc ggtcggtatc ttcgctgcta ctcgacccgc tctcccaggg agatggaacc
     9541 ttgttggtcg atgtgcaatt gtcgatgggc gctgcgagcg catgcaaaac aggaacgaca
     9601 aaagaatcgt ttgccggtac agctgaacat ggtgccggcg cttgggtgag aggagttgtt
     9661 gccatgaacg ccctgctcgt gggcccgcgc gacgcgggac cgtccaccgc ggacctggac
     9721 atcgggttct tcgacagcga cgaggaggtc gccgcgcacg gaccgcaggc atgtgcgccc
     9781 acctgcaaca gcggcctgac gttcgtctgc gatggcgatt cggcccacac gtgctcctct
     9841 gggcgaactt tcatctgcga cggctagcgt cgagtctgcg gagttcctga gccgggaagg
     9901 tggttgtttc tgcggccacc tttccggccc caccgggtga gaggttagtg gattggtttc
     9961 ttcgctgcgg ggcgagttgc tggccaatgg tctttctgaa atggtcggcg agttcggatg
    10021 gcggacccgc gccgggcggg tttgggtgca ttgtgatccg ccgtcggtgt cgcttccgga
    10081 acagggctgg aagattcatg tttccgctcg cccggccacg ttgccggaga cgttgcgggt
    10141 cgtggttccg cttctggtgc gccgggggtg tgcgttcaag gtggtcaacg ggcgggaggc
    10201 gctggccgag ttgaacgccc cggacgaccg cgtgtcgtcg gtgggcaagg cgatcacggc
    10261 ctatccgtcg ccggagctgt tccgggagct ggccgtcgag ttggcggagg cgctgcgcgg
    10321 tttcgccgcg ccggtggtgc gcagcgatcg ccgggtgcac cccgaggcgc cggtctacta
    10381 ccggtacggg ccgttcgcgg cccggtatcg ggtgagcctg aacggacagc ccgagctggt
    10441 ggtgaccggc ccggacgggg aagagtaccc gggagcggcc ggccggttct tcggctgccc
    10501 gccctgggaa cgcgacccgc tcagcgccga ccaaggaccg ccgccggacg acggcgaggg
    10561 accgccgccg gatgccgacg aagtaacgcc ggtgggcaag ggcgcgccgg tgggcgacgg
    10621 cgatcccggc gtggtgctgg gcgggcgctg gcggttgcag gagggtgtcc agaaccgttc
    10681 gcgcggacgg atcttccggg gccgggacgt ggtcaccggg cgggaggtcg tcgtcaagga
    10741 ggcgcgagcc tacatcggcg gtgagacggc cgacagcgac tgccgcgcga acctgcgcag
    10801 cgagcggcgg gtgctggcgg cactggacgg tgtcaccggg gttccccagg tgctggatca
    10861 tttccggcac ggcgaggacg agttcctcgt gctgtcctcc atggggcgac gcaaccttgc
    10921 ggacgacgtc gccacgtccg gtatctaccc cgaccggccg ggcgagcggg acctgtcggt
    10981 gctggcgcgg gaactgctgg tgctcctgga cgccgtccac gagcgcgggg tggtcgtgcg
    11041 cgacctgagt cccaagaacg tggtcttgga cgaggcgggc ggatgccatc tgatcgactt
    11101 cgagctcgcc cggctcgacg ggcggcaacg tccgggatac agccgcggct actgctcacc
    11161 ggagcagttg cgcggcgagc cgggcacggt cgccgacgac cacttcgccg tcggcatgac
    11221 cctgttctac gctgccaccg gcatcgaccc ggtcatgatc caccgggacg cgctgcgtga
    11281 cgccgagcag tcactggcgg tgctggcggg cgcgtttccc gacggcgggc cgactctggc
    11341 tcggattccg ggcctggtca gcgccgaccc cgccgaacgg atcgccgccg tcggcgcgct
    11401 ccgggccgga gacagcggcc ggttcaccgg ctggagccac catccggccg aagtggacac
    11461 cggaacggtg gcgcgggtgc tgacgcacac gctggcccag accgtccggc acggcaagga
    11521 actgctcacc tccgactcgc cgtcgggacc gatgcggctc gacgtctggc agggggccgc
    11581 gggtctgggg accgagctgc tgcatcatct caccgacggc accgcacagg cgctggccgc
    11641 cgacctggcc cggaacacgg ccgagcaccc cctgctcaac gcctacccac agggactggc
    11701 cttcggccgg acgggcatcg cggtgttcct ggccgccgcc ggacggcggc tggacgatga
    11761 cgacctgcgc ggcgcggcgc gccgcgccgc gccgcccgac cccggtctcc tggcgcgggt
    11821 ggagtactcc gactacgcgc agggactggc cgggatcggc gcgggtcatc tgatgctggc
    11881 cgagctgacg ggcgacgggg cccatctggc cgtcgcggcc gagtgcgcac gccggatcgc
    11941 cgacggcgag tgcctcacct cggcggatga caccgccgac cccaccaacg ggatcgtcat
    12001 cggcctcggc cacgcccacg gacgcgccgg gctgggcgcg ttcctgctcg cctaccacac
    12061 cgtcaccggc gaccggcggg ccgaggccgc cgcgcacgtg cagtacgccg tgctgtgcga
    12121 gcggttgccg caggtgctgg ccgccgccgc gcgcccctcc gcccggccaa tgtgcgcgtc
    12181 ctggtgtcag gggctttcgg gaatcgggac atccctgctg cgcgccgcag cactgggcga
    12241 cgaccggtgc ctgcggctgg cccaggacgc ggccgagacg tccctgctga tggcgccgcg
    12301 catgggcatc gtcacgcagt gctgcggcat ggcgggcgtc ggtgaactgc tggtggacct
    12361 cggcgcggcc accggacaga acacctggtt cggcgaggcc gaacgggtgc tgggactgat
    12421 gctggaccgt tgcggcggag aacccgacac tcctgcggag ttccccgaca actccctgcg
    12481 cggcggcagc gggggatggg ccaccgggag cgccgggata ctgacgctgc tgcgccgcgt
    12541 gcgcgaccgc ggcggcgccg ggccgtggac gttcggccag tggacggcgg cgtgaccacc
    12601 ggcacggccc ggccccgcac cgaagaacgg tgcgcggcgg ggatagacga gcaggccgtg
    12661 ttcggcgggc ggccgcaggc tgtgaagacc ggcagcctgg cgatgctgcg cgaactgccc
    12721 ggcgcgatcg gtcagaccat cgggctgctg tggacggccg gccgtgggct cacggtcacg
    12781 gtgctggcct gccagaccgc cgctgccgcg ctgaccggcc tggggctgct ggccggcacc
    12841 cgcgtgctgg ccgcgctcct ggccggcggc ccgaccccgc agcggatcac cgccgcgtta
    12901 ccgtctctgg cgttggtcgg cggcgtgctg gcggcgcgcg gcgcgctgac cgccgccgtc
    12961 gcagaggccc agtcccggct gacgccccga gtcctccgac acgcccacga ccggctgtac
    13021 gaggcgaccg ccgccgtcga actggccgcc ttcgacgacc ccgactggca ggaagcactg
    13081 tcgcgggccc gtcagcgcac actgcccgcc atcgaacttg ccgtcgcgga actgctcgcc
    13141 gtcgccgccg ccatcgccgg gctgctcgcg gtcggcggga tcctcgccac gctgcacccc
    13201 ctgctcctgg tcctgctgac ggcctccgtc atcccgcaca cctgggccgc gatgcgcgcc
    13261 gcccgcaccg cctacaccgg ggaaatcccc ctcgccgccc tctaccaccg ccagcaactc
    13321 atcgcagatc tcatcaccgg ccgcccggcg gccgccgaga tccgtgccta cggcgccgaa
    13381 cggttcctgc tcgccgagta ccggcggtgg gccgaggccg tccagaatca gcggcagcgc
    13441 ctggaactca cccgcgcccg aaccaccatg gccggacgta cgctcggcgg gatcggcgtc
    13501 ctgatcaccc tgatcgccct cggagcgctg ttgaacgcgg gggtgatgcc gctggccgcc
    13561 gccgcgaccg cggtcatggc gatccgtgcc gggcaggcgt ccttcgtcca gctcgcgacc
    13621 accgccaacc ggttgtacga acgcggcctg tacatcggcg acttcaaccg gttcctcgcc
    13681 gacagccacg cgcgcgccca tcaccccacc ggcgacccga tgccccgcga tttcgccgcg
    13741 atccatttgg acgatgtcac cttctgctac ccgggtaccg agaagcccgc cgtcgaaggc
    13801 gtcgacttgt ccctcgtcca gggtgaggtc atcgccctgg tcggtgagaa cggctcaggc
    13861 aagaccaccc tggcccgcct gctggccggc ctgtaccggc ccacggccgg gacgatcgcc
    13921 tggggcggcc cctctccgcg tgtcctcgcc cccggcgacc tgcgccggct ggtggggctg
    13981 ctcgggcagg agccggtccg ctggcccctg tccgctcacg acaacatcac cctgggacga
    14041 ccggctcccc gcccgtccgc cctggaccgc gccctcagcg aagccggagc agaccaggtc
    14101 ctcgccgggc tgccgcacgg cgccgaaacg ctgctgtcgc ggcacctgca cggcggtacc
    14161 gacctgtccg gcggccagtg gcagcggctg gccctcgccc gcgccctgta cggcgccccg
    14221 tccatactca tctgcgacga gcccacagcg ccactggacg cacgcgccga acagcgcgcc
    14281 tacgacacga tccgccggca ggccgcccag cacggcacca ccgtcgtcct catcacccac
    14341 cgcctcgcca gcgtccgcca cgccgacaag atctacgtcc tggaccacgg acacctcatc
    14401 gagcacggaa cccacgacga actcctcgcc cgcaacggcg actacgccca gctctaccgt
    14461 ctccaggccg ccgcccacgc tccccccacc cctcaccggc gcgagactcc tgaccccgcc
    14521 cggccatgaa ccgcgagatc aagcacccgc gtcccaaccg ccgaatgaaa ccggccccga
    14581 agtcgggcaa ggcccttgag cagtgggaac gatggcacct gcacggatgc ggccgatgcg
    14641 ggcggcacgg ttacgtcgca gcacgctggc ccgacggaca cgtatgccgt acctgccaga
    14701 gcaaggccct gcgcattcgg gggatctgcc aaggctgcca aaccgagcgg atgccgcccg
    14761 gccgaggcaa gaacggtgaa ccgatctgca cccagtcccc gaaccagcgg cggccctgct
    14821 cctcgaactg gccgccaacc gctcgaacac gaacaccgcg accaacccat acgcccgatg
    14881 gctgttcccc ggacgacgcg ccggccggtc gctcaacccg gcaccctgcg cgaacagctc
    14941 cgccaacacg gctacatgac cggcgaagcc cgccccgccg ccctccgcca actcgtcctc
    15001 caagccccag caccggtcat cgcccgctcg cttggcttcc acgacaacag caccacccgc
    15061 atcgccgccg aagcgggcgg gtcctggaac cgctacgccc ccggcgatca caccaagtga
    15121 ccaacgaagc caggcgagga acactttggg cggcgcggct gaggccggtg ggttcggtag
    15181 gaccccattg gtactttctc cgatgcggtc gggggttcgc ggtgccaccg tgtgatcatg
    15241 tggatcggga gcagccgccg tcgtcctggg tggcgagggc cgtgcgggca cggtgagcgt
    15301 gatgaccgag cctgattggg aggggcgtct ggccggaccc gcggccatgg gacggctggt
    15361 ctctcgggcg ttcgaggacc ggctgcacgg gcgcggtctt ccccgcgccc gggtcgacct
    15421 gctgtgcgtc tccgcggacg tcctggccgc cgctgagctg gcgggcatgc gaccgtcccc
    15481 ggcagatcag gcactcagga gcgtgctggg cgtgatggcc gcggcgtggg aacaggccat
    15541 gaccgcgcac ggaatgctcc gcggcaccat cgacgcgtgc cggcgggagg tgggccgcga
    15601 ggttgaggaa ctcctggacg agcacgccag gctcgtgcgg ggacggcgcg cggcggaccg
    15661 gccggtgccg tgcccgccgg cggaggccga agggatgtag gcgatgctcc ggacgtcccg
    15721 gcacggcagc cggcggggcc gatgggtggt gtcctgaccg gtgcgtggcc ccgtggacgg
    15781 cgtgagtccc agcggccggg cccgggcggc tccgccgaac acgaagacca tttcgacttt
    15841 gttgcgtggg gtgtgcggcg tcctggcggt ggtggggccc cggcgcggca gccccttcag
    15901 gacagcgcat ccctgttggc aagcaagagg gctccgcggc ctcccgtacc ggcatgcccg
    15961 taccggcatg cccgggccag gcgcgcagag cagggtgtcc ggcgcagcta cgccggccag
    16021 gcgcgttagg tatcgcgggt gccggcggag acggctctca acaatcgcac ccggcagggg
    16081 ttaggtacgc gcattggtac atccactgat gcacgtaggg tgcgcgagcc gcgacgataa
    16141 gtgaccgtgc cgggcgggag cagtggcctg ccctcggggg agggcggggc gcgcgaccac
    16201 ggcgggctga gcgcgaccaa cgcggcttcg cccggcgatg cgcccgcgcg gccgccgggc
    16261 cggcggtcga gccctggggg gacccgaccg ccggcaccct tttccgatcg tcgggctcac
    16321 ccgggctcga ccgcctccca ccccgctgaa gcccctgccg cccaaggcgg ccgctcccgg
    16381 ttgaacaagg attcacgccc tctacccgag gagatggaat cgttggacca gacgagcgag
    16441 gccgacgccg agcaagcacc ggccccgagc aacgcaccga cactgaccaa cgcactggca
    16501 cccttctgtg gatccagtga gccatgaccg ccccgtgatc cgtccgtccg gcggcgggtg
    16561 tggcaggtgg ccggtccggc gcggccaccc tcgcgtgcgt ggaaccggcc ccgggccgga
    16621 cccggcgtgg agaagcctcg acgccgggct ggcgcatgcg tcggctgttt ctgtgggcga
    16681 ggtctaggct tgatcagcct ttggtcgaag ctgagccgtc gtaccgagga gagcctctac
    16741 gccgaggctc cgttctttca cggtcgttgc atctgcgccg gagcagcccg aggctctccg
    16801 gccgtgcgct gtctgaccgt caagccaggc acgggcgggt ccgcatcagg gattgcccag
    16861 catctttgcc gcgagtgcgt gcaaaggcgg aggtcgctgc tggcgctgct gcgaaggctc
    16921 gggagaacac gtcattcggc gcgctgacca agccccgagc acatcggaac gaaaagtaac
    16981 gccaccctcg gaccgagcca ccgcccagcg cggattttcg ttccgctgct cctcaacccc
    17041 catctcacgc gatcgtctac aaaacctcgt cttcgtgcac gccgatggtg cgctggcgga
    17101 cgagtccggc ctcgtctccg gctgggtgct aatgcgcgag gcgcgcatgc tggcggttcc
    17161 tttgggccat tccttcgccc ggcaggagtc gcggtcccgg ggggcggtcc ctgaaaagga
    17221 accgcatccc aggcgattcg ccgaccagac ggcggtgagg ggccgggatc ggacgggagc
    17281 cccgctacgc agctgtgaat gggtgcggtc cggccgcggc gtcctgcacc gcggagttgg
    17341 ggtacgcgaa tcggtatctt gacccatgcg cgatgggtga ccgcctcgcc accatgggtg
    17401 ccgtgtcggg gcgagtgcag cggccgcccc tctggcgaat gcggcggcca catgatcatc
    17461 gcgggtgaag tgcgacaggc ttggcttctc cggatgaggt gcccgtttcg gtcatgttcc
    17521 ggcgggctgt cgagcggccc gccggtccgg tcggtcggga tccgggggga cccgaccgcc
    17581 ccaggcggcg tcactgcggc actatggcgg cccgacgtcg gctgccgagg ctttctgggg
    17641 gatgcggtag gtcatcaaga cgaacggagg gcctgtttcc cctgcggtga atcgcgggct
    17701 atccaccgtc gactccggct tgggggcggc gcagccacct attcggccgc gggcggcggc
    17761 agacgaatgc aatgtcatcg ttgttcccct ccatcgcaac ccgggaagcc cccacgcgcc
    17821 agcggggcga ttctctcgat cggtgcggca ggggtgaccg cgcgcgggcg tcggcgctgc
    17881 cgtaaaccga tcggaaaccc gcggggcagg tcccaccggc ccgtgattcg ccgttcaagc
    17941 cgagtcggcg cgcgccgcca ggagctactg ccggtcggcg atggtggtga cgatcgggtg
    18001 gaacgcgcaa gcggtcgccg cttccatcac ggcagatacc ggtgccgttg acgtctcggc
    18061 cgacggccac ggggtggtac gcggaaccat ttgccggtgg ccattgcccg atacgacccc
    18121 gcggaatccg ctgcgaaacc tctcctcgaa gtgaaagggt catgatgtta cgcagaggga
    18181 gggtgtcgtg acgcggtggc agtgggcgcg ggtcggggtg cggcatgaac cgacggggtt
    18241 catcggccgg aaggccgagt tggaagcggt ccgcgagagc gtgtcgcgct cgcgggtggt
    18301 gacgttgacg gggccgggcg gggtgggcaa gacgcgcatc gcgttgcggg ccgcgcacca
    18361 gctcggcgcc gagttccccg acggggtcgc catcgccgag ctcagcggcc tgcgtgacgc
    18421 cgagctgctg ccgaacacgg tggcgtcggc ggtggggctg cccgaggtcg ccgcgcagca
    18481 gccgatggac cagctgctgg atcacttcgc cggtaagcgg gcgctgctgg tcctggacac
    18541 atgcgagcat ctggtggacg ccgtggcggt gttcgccgac atcctggtgc acggatcggc
    18601 gggcctggtg ctgctgctga ccagcaggca gcccgtggcg ttgcccggcg agttcgtcct
    18661 gccggtcgag ccgctgcccg aacccggagc ggaggcgtcc gagagcacca acgacgcggt
    18721 cgcgctgttg gtggcccggg ctcaggcggc ctgcccgtcg ttcactctca gcgacgacaa
    18781 ccgggccgag gtcgtcgcgt tgtgccgccg cgtggactgc atgccgctgg ccatcgaact
    18841 ggcggcggtg cggctgcgga ccctgtcgct ggagcagatc ctgcgccggc tggacgaccg
    18901 gttccagttg ctcaccgggg cccggtcggc ccagacccgg catcaggcgc tgcggacgac
    18961 catcgaatgg agccatgacc tgtgctcacc gcaggagcag cagctgtgga gccggttgtc
    19021 ggtcttcgcc ggcggcttca ccctggcggc cgtcgaggag gtctgcgccg gtggggatct
    19081 ggacggcttc gatgtgatcg acctgctgct cggcctgatg gacaagtccg tggtgcaacg
    19141 cgtcaacggc gtggatgagg accgctaccg gctgctggac gcgctgcgcg agttcggcgc
    19201 cgaacggctg gcgcgcgacg gcactacggc cgtgtacgcg cggcgccatc tggagttctt
    19261 cctgcagatg gccgaccagg ccgaccggca gtggatgggc gaccagcaga cccagtggag
    19321 cgagcggctg gccgccgacc tggacaactt ccgcgtcgct ctggaacacg ccatcgccga
    19381 tccccaagac gaggccgcgc tgcgcctggt caacgggctg tcagggctgt ggcagggcaa
    19441 gagccgcctg accgaggccc gccgctggct cgatcgggcc atcgccgcgg cggcggagcc
    19501 gaccttcgag cagggcaagg ccctgtggtc ggcctcctac tacgggctgc tgcaggccga
    19561 cccggcggtg accgagacgg tccgccggct gcgggcggtg gccgaacacc tccaggacga
    19621 gttcctgcgc gcccgcgcat cgaccgccga agcctatgag caactgctgt gggtcgacac
    19681 ccgcgcggcg ctcaaacagt acgagccggt gcgcgcggcc ttggccgcca ccggcgaccg
    19741 tttcaccctg atcatcagct atccgcagac ggcggcgggc tacaacgccg tcggcgatcc
    19801 ccaccgcgct cttcaagagg tggaggcggg gttgcgggaa ctggaatcaa tcccccagga
    19861 acgctgggca cgcaaccatc tgctatcgat gaaagtgctc tgcctgtgcg cgatgggcga
    19921 gttggacgcc ggccgcgacc tcgggcggtc gatcctgccg tccatcgtcg aacaaggcga
    19981 gacgatgtgc gtggccgccg tgaccgaata tctgtcctgg gcggcctgcg gcaacgggga
    20041 acacgaccag gccgcgacac tgctgggcgc ctccgtgacg ttgtggcgca aggtcggcgc
    20101 gctgctgtgg ggagcccccg ggctgatccg ccgccacacc gacgtcgaga acgccctgat
    20161 gatcgacctc ggcgccgacc gcttcaccca ggcctacgcc cgcggaaccg ggctgtccat
    20221 gcccgaactc ctccagaccg tcgccccggc ctccgcggct ccgcctcctc ccgcgccccc
    20281 ggtcgaggac cgcggccccc tcggtgccct caccgaacgc gaacggcagg tcgcccacct
    20341 gatcaccgag ggcctcacca accgtcagat cgccgaacgc ctcgtcatct ccaaacgcac
    20401 cgccgacgcc catgtcgagc acatcctggc caaactcggc ttcaactccc gcacccaggt
    20461 cgccaccatg atcgccacgc acaaacaaga ctgaacccgt tcaccaccgc cacagcgggt
    20521 cgccggcagc gcgacgacca gcccgttggg ggcatcccag cggggcgcga cgtcgagact
    20581 gaggcccgcc gagaccctgg tgatgtactc gcagttgaga taggaacatc tttgatcagc
    20641 tggccgggga caagccgatg ctaccgccgg agccgtacac cgcgacctac tcaccgccac
    20701 ggaacctcgc ccagggcctg tttcggaagt tgtgagagcg ctcctatcat gatcgcggat
    20761 ccgcggacgg tgagaggacc cgccatgtgg agagagttga tcgggcggct ttacagcgat
    20821 gctgagttcg ccgcgcctgc tcccgatgag gaaattgatc agatcgagca gcgattgggg
    20881 caaagggtgc cggacgaact acgagagctg cttcgtgaga ccagcggggt gcaggacgag
    20941 tacggatccg gactggtgtg gtcggtgcag gagatcatcg agcagaatac ggagtttcgg
    21001 cagagcgcag acttcgccga gctctacgcc tcgttcgacc agctcatgtt cataggggac
    21061 aacggtggcg gggatcagtt cgcgtttgtc caggcgccag gggaacggct cggcgatgta
    21121 gtcgtctggg atcatgaaac cgacgaacgt acctgggttg ccaggtctct gaaggactat
    21181 ctggagtcgc gggcggcctc ggacggcgac gactggtaca agcaggggtc tggccagtga
    21241 actgtcacag ccattcgttg atgcaggcga tgtgcaaggt cgcctcgtag cggacggcga
    21301 gcttgtcata cctggtcgcg accgcccggt tgcgtttgag ccggttgatc gcgcactccg
    21361 ccgcgtggcg ttcgcggtag tcggccttgt cggcccggac acggcccggg cgggtgcgcg
    21421 gtaggccacc gctgcggtgg ggaacccgga tgccttccag cacaggcttg aactgcgcgg
    21481 aatcgccccg ctgcccggcg gtgaccacga gcgacaacgg cctttggccc tgctcggcgg
    21541 acaggtgcac cttggtggtc agcccgcccc gcgaccggcc gagcccgtga tctgcaggtc
    21601 cactccgcac gccgcccggc ggctcctatt ggtcttccct tttttcgcgc accggcggcg
    21661 tgctggtgcg cgcgagcgat ggtggagtcc accgggacgt tcctggctct gccgatgctg
    21721 gatgctcaca tcggcaagcc gctggatctg gccgggatcc ccaaccacgt cgacagactt
    21781 atcctgatcc ggtcggacgc tgccccttac gtaccaccga gccacaacga ccgtcctacc
    21841 aatctcctgg gaacaacgac ccaggtcatt cctagagccg gccacttcct cgcgtccgac
    21901 ggtgtgacgt cgcttcccgc ggccctcgaa gcgatcgcat cgtccagaaa ggctgacgga
    21961 aggctgacga gaaccagatg acacacaccg caacgcgcca ctctcacccg agggggctgg
    22021 ctcaccggga aaggcgggtg accggccgct ccctcgccga cgacgaggcg atcggcacct
    22081 tcaccggcct gctgcgacac ggcctcaccg gccccgctcg cggcgactga ccgatcacca
    22141 gttcggagca tcgtgctctg gcgtgttccc ggccggtgag gcagagggtg ggccgtcgac
    22201 ggtgaccgcg ccggatcgcc ggtcgcggag tccgacggcg accagcccgt cgcagtggta
    22261 ctcgaaggtg cgggtcaggt ggaggcggac cgaccacacc atgccccacg atccaggctg
    22321 agcctggccg agcgcgtcgg tcaggtccgc gatcgcctgc tgccggtcgg agttgacccc
    22381 gcccggtccg gcgcgccgcc cgtccctgct gtgaacgttc cagtcataca gctcaccggt
    22441 catgctcgcc cgaccacgct gctgcggcgg cgatccagca gggcgcctgg ccttgctccc
    22501 ggccatctgg ccgccgcgcg cgtggcatcg ccggaggagg accgctccgc ccccgtccag
    22561 agacgacggc gcaggcagcg gcgctccctg gtcgc
//
