LOCUS       NZ_CP053892            29581 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9287022
            Orig. end                         :: 9316603
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..29581
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="bottromycin"
                     /product="ectoine"
                     /region_number="28"
                     /rules="botH"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..29581
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="botH"
                     /detection_rules="ectoine_synt"
                     /kind="neighbouring"
                     /product="bottromycin"
                     /product="ectoine"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..20774
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="botH"
                     /kind="single"
                     /product="bottromycin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20774
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10774](+)"
                     /cutoff="20000"
                     /detection_rule="botH"
                     /neighbourhood="10000"
                     /product="bottromycin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10774
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="botH"
                     /neighbourhood="10000"
                     /product="bottromycin"
                     /protocluster_number="1"
     misc_feature    complement(1265..1279)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(1874..1888)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            2400..3623
                     /locus_tag="ACTIVE_RS41820"
                     /old_locus_tag="ACTIVE_8390"
     CDS             2400..3623
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889675.1"
                     /locus_tag="ACTIVE_RS41820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8390"
                     /product="SLC13 family permease"
                     /protein_id="WP_246342515.1"
                     /transl_table=11
                     /translation="MSPPIETVRRAARSLGVLDWVRIGVLVLGLVFVATGLLPADSARS
                     SLGRIAPLLLFLFAIIVLAELTKEAGVFDAIAQRVARAGRGRYAALFLLCVAFASVNTI
                     FLNLDTTAVLLTPVMLALAARARIAALPLAMTTVWLANTASLLLPVSNLTNLLAADRVA
                     LETPEFAARMWLPQAAVLAVTMVLLWVFYWRRRMRGEEAYDPPEPVPVRDRVLFSTTGI
                     ACLFFIGAILAGVHTGIQLGITTTIAAAVAVAAFAVRDRSVLRPTLIPWQLMVFVTGLF
                     LVVPTLERYGLDDAMRALVGTDDGASGAFRAGFSGAGLSNVLNNLPAYVAGESAVPAAN
                     KDQLLSLLVGTNVGPVITPWGSLATLLWFEWCRRWNVRVPMRKFVLTGAALAVLGCTAA
                     VGTLLITS"
     gene            complement(3653..4510)
                     /locus_tag="ACTIVE_RS41825"
                     /old_locus_tag="ACTIVE_8391"
     CDS             complement(3653..4510)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543767.1"
                     /locus_tag="ACTIVE_RS41825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8391"
                     /product="inositol monophosphatase family protein"
                     /protein_id="WP_173100131.1"
                     /transl_table=11
                     /translation="MRTSTPSPARPVDLAEARRVAVEAAEAAGTLLRSRVDGPVDVRPK
                     GAAGDVVTELDTAAEALILERLRATYPGHRIIAEESGILDGAPGEEMVWLVDPLDGTNN
                     VAIGMPVYAVGVALCARAEPVLGVVHDPVTGRTWSALHGGGAQGPDGAPLTLPEHPRPG
                     RERNPVLAWTQGHQVGPGDAAAFRLRSRVEAGCARMLQLWAPLVGWAMLARGDIDGIVG
                     YLPEIVDLPAGALLAAEAGAELRRLDGSPYELGIDRPPSELSFVAARPELLDRLLETAA
                     GSAL"
     gene            complement(4540..5286)
                     /locus_tag="ACTIVE_RS41830"
                     /old_locus_tag="ACTIVE_8392"
     CDS             complement(4540..5286)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889677.1"
                     /locus_tag="ACTIVE_RS41830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8392"
                     /product="hypothetical protein"
                     /protein_id="WP_173100132.1"
                     /transl_table=11
                     /translation="MRYEEIQGDIRAGRAARTLPAWAGRVLEDAAAGRSPVAAVRHPLG
                     FLCLPVERSGDLGVCLHIWTPEVRPVPSTTSPVHCHSWDLLSFVLYGTVRNVRMDVLEG
                     PGAAAEGAGQVFEVVSSGDVDELRATGRAVRYRPGPSATHRTGESYTLPAGVFHSTLIE
                     DGLDAATVALGRQTPGGGDLSLGPLDVPTHRVLRARCDPGETVRALRRSAHRIAAARPG
                     PAGAAEPPGEPPSSGPHGCRHRSARR"
     misc_feature    5318..5333
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            complement(5330..6343)
                     /locus_tag="ACTIVE_RS41835"
                     /old_locus_tag="ACTIVE_8393"
     CDS             complement(5330..6343)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543765.1"
                     /locus_tag="ACTIVE_RS41835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8393"
                     /product="hypothetical protein"
                     /protein_id="WP_173100133.1"
                     /transl_table=11
                     /translation="MTRFANWLGKNADAFIALVLAITVAVLGLGVNLPHENEITQSAIL
                     AVIALLATSVLRDRGRRIPVEAEVRDTLRASASTLDELSGRLAHIEEFEGVLAGTKRAL
                     DETAVVRVIGGGQVAQVLEEARRDTDRWFFKGGTGTYIRAKTLPECVAAARRDRRTLLF
                     RLEILDPTNVEVCEAYARHRRSVSDAPDATGEKWTLERTRKEAYATLLAACWHKQRFGM
                     LDIDIGLAQTMTTLRYDLAASRLVVTRDDPRGEALVVDNDKFYYSWVSAELQTSLDQAR
                     RVPVEQARLAPLDDEPTVEEVRRLFEVIAIPLAHSYTDRDVIEIIRKALRAKDPYE"
     gene            6569..7720
                     /locus_tag="ACTIVE_RS41840"
                     /old_locus_tag="ACTIVE_8394"
     CDS             6569..7720
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630646.1"
                     /locus_tag="ACTIVE_RS41840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8394"
                     /product="histidine kinase"
                     /protein_id="WP_173100134.1"
                     /transl_table=11
                     /translation="MHLGAWWSAAWPTRRSRVLDVALAVTFAVLDGLFLWFSPQHFWLP
                     HTVTSACSVVLGLTIVVRRRHPVALAVFATVFSAVTGGGAFVILVILYSLAAYAASRRV
                     VLAIAALNYAVGLAFPPPTASRDSFLVQVIFGVTFTVVPVLLGLYMGARKQLLVSLQER
                     AARLEREQNLLAERARGEERTRIAREMHDVVANRISVMVVHAGALKAVAARDPGRAAET
                     AGVIGDMGRQALEELRHVIGVLRQGEEALPQEAVTLEHVRELIGQSGAAGLRVVLSVRG
                     VERPMPTAVGRTLYRLVQEALTNVHKHAGAADTRVDLGLLPEAIEVEIANDPPTAPPAH
                     GLPSGGHGLVGLRERVTALGGSFEAGPRGGGYRVSARLPLPAS"
     gene            7827..9944
                     /gene="uvrB"
                     /locus_tag="ACTIVE_RS41845"
                     /old_locus_tag="ACTIVE_8395"
     CDS             7827..9944
                     /EC_number="3.1.25.-"
                     /GO_component="GO:0009380 - excinuclease repair complex
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006289 - nucleotide-excision repair
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="uvrB"
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013152016.1"
                     /locus_tag="ACTIVE_RS41845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8395"
                     /product="excinuclease ABC subunit UvrB"
                     /protein_id="WP_173100135.1"
                     /transl_table=11
                     /translation="MRPITDLRRRVAPFEVVTEMTPSGDQPAAIAGLAERVERGDKDSV
                     LLGATGTGKTATIAWLVEKLQRPVLVMQPNKTLAAQFANELREMMPGNAVEYFVSYYDY
                     YQPEAYIPQTDTYIEKDSSINDEVDRLRHSATNSLLTRRDTVVVASVSCIYGLGTPQEY
                     VDRMVRLRVGQEIERDDLLRQLVGMQYSRNDLAFTRGTFRVRGDTIEIIPQYEELAVRI
                     EMFGDEIEKLATLHPLTGEVITEDEELYVFPASHYVAGPERMERAIRDIEAELEVTLAD
                     MERQGKMLEAQRLRMRTTYDIEMMRQVGTCSGIENYSRHIDGRGAGTAPNTLLDYFPED
                     FLLVVDESHQTVPQIGAMYEGDASRKRMLVEHGFRLPSAMDNRPLKWEEFLDRIGQTVY
                     LSATPGTYEMNRVKGDVVEQVIRPTGLIDPEIVVKPTKGQIDDLIHEIRLRTERDERVL
                     VTTLTKKMAEDLTDYLLELGIQVRYLHSEVDTLRRIELLRELRAGEFDVLVGINLLREG
                     LDLPEVSLVAILDADKEGFLRSETSLIQTIGRAARNVSGQVHMYADTVTPSMERAIDET
                     NRRRAKQQAYNEEHGIEPTALRKRIADILDSLAREDADTETLIGGAGRQQSRGKAPVPG
                     LASRTKEVGRHAADLVGERPREELEGLIEQMTEQMHQAAADLQFELAARLRDEIKELKR
                     ELREMKEAGVK"
     gene            10001..10774
                     /locus_tag="ACTIVE_RS41850"
                     /old_locus_tag="ACTIVE_8396"
     CDS             10001..10774
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (19-122). E-value: 1e-22.
                     Score: 72.9. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS41850_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     bottromycin: botH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012770.4"
                     /locus_tag="ACTIVE_RS41850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8396"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_173100136.1"
                     /sec_met_domain="botH (E-value: 3.4e-19, bitscore: 68.3,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 8.1e-19, bitscore: 67.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.2e-13, bitscore:
                     48.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRTGPEGRRIAWETVGSGPPLVLLHGSFGDRGTWWPGGHVGALA
                     GEHRLVLIDAIGHGESDAPDDPAAYRIDRQAGDVLAVLDAEGAGRAAFWGASMGGTIGF
                     HLLARHPERLTCLIASGAHARGLGADPADVEREAAFCRDRGAAPFVEAVERRGALPGWM
                     RDAMLAIAPEALAAQTVGLFELPDVTAAVAEAEVPVLLLAGDGDHRLPAIRRTAEAVPK
                     ASLLELPGCGHLDAFLRLDLTLPVVRPFLRRYATA"
     aSDomain        10058..10366
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS41850_Abhydrolase_1.1"
                     /evalue="1.00E-22"
                     /label="ACTIVE_RS41850_Abhydrolase_1.1"
                     /locus_tag="ACTIVE_RS41850"
                     /protein_end="122"
                     /protein_start="19"
                     /score="72.9"
                     /tool="antismash"
                     /translation="PPLVLLHGSFGDRGTWWPGGHVGALAGEHRLVLIDAIGHGESDAP
                     DDPAAYRIDRQAGDVLAVLDAEGAGRAAFWGASMGGTIGFHLLARHPERLTCLIASGA"
     gene            complement(10781..11263)
                     /locus_tag="ACTIVE_RS41855"
                     /old_locus_tag="ACTIVE_8397"
     CDS             complement(10781..11263)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025054.4"
                     /locus_tag="ACTIVE_RS41855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8397"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_173100137.1"
                     /transl_table=11
                     /translation="MATVRLLEAGDWALYRSVRLASLTESPAAFWSTLAREEAFAPSVW
                     QDRLAARNTLLAETGDGPAGLAAVVPDEGAAAELVGMWVAPSARGRGVGDLLVRAALDW
                     TADRGFAELRLWVFEGNRHAERLYARHGFARTGTAKPGRPGTDERQFEMARAATAR"
     gene            11358..11870
                     /locus_tag="ACTIVE_RS41860"
                     /old_locus_tag="ACTIVE_8398"
     CDS             11358..11870
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657174.1"
                     /locus_tag="ACTIVE_RS41860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8398"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_173100138.1"
                     /transl_table=11
                     /translation="MEYDVRPARPGDLPRLPAIEDSGDRLFGALGIVFPPHPTVAEEMI
                     AKGAEFLVAGDPPVGFAAVEEVDGATHLEQISVHADLVGRGIGARLLRAVKEGAAGRGS
                     PGVSLLTFRDVPWNRPWYARHGFAELPRERWGPGIRAYWDAEIAAGLHELGPRLVMWAP
                     LPPPGTG"
     misc_feature    complement(11942..11958)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.09"
                     /tool="antismash"
     gene            12011..13054
                     /locus_tag="ACTIVE_RS41865"
                     /old_locus_tag="ACTIVE_8399"
     CDS             12011..13054
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630638.1"
                     /locus_tag="ACTIVE_RS41865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8399"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_173100139.1"
                     /transl_table=11
                     /translation="MTPGSWPRRLRERLGDRGLAVLVLVGLLALAVVPLVAMPAARCKT
                     FGSGCPKPKPPVRADPVVTQEGQVTPLQAATRGAYVALGDSYSAGVGAEATVADRNPLN
                     RCRRTSKAYYHEVSAAFRFAKGSSFWACSGATTADILKGRYGEPPQLDRVDAGTSLVTI
                     SIGGNDVGFSKVLGGCVMRLPWSHSCTDQGKDIADRMAKLRLALPALLEKITDRAPSAR
                     VIVMGYPKAFSEVTGAGGDNITVSDQQWLNARAYDLGRLVRQSVVEADARVVARHGRGS
                     VEFVDAYSAFAGHEAGSADPYMNGLALNLSALEAEPRSFHPTAAGQHALAQLFIAQVNR
                     GPGRPLT"
     misc_feature    13092..13103
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.66"
                     /tool="antismash"
     misc_feature    complement(13176..13191)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     misc_feature    13218..13227
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     gene            13271..14050
                     /locus_tag="ACTIVE_RS41870"
                     /old_locus_tag="ACTIVE_8400"
     CDS             13271..14050
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024758.4"
                     /locus_tag="ACTIVE_RS41870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8400"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_173100140.1"
                     /transl_table=11
                     /translation="MPNALRRTLAAALVAAGLSLPALPAHADTTTPVPIGGGSGIVQQL
                     KQVSPGGGYSFELCTLTAIGHDAEGNLVGLTNAHCFLDADGNKLVGDTVYDNTTPAGTP
                     AANAPATFDFDATMAIGPIGKVTYVSEPNNLLSGGPKGLDYAVIKLDPAKVTPAATVSA
                     PNGSTTIDSIGQVPGFGTRMCKMGHTTGVTCGITLGTDGPWYLTAIWTSPGDSGSPVVN
                     GTALTGTAFGLQHFTPITSILADMNARGGVGAGFHIG"
     misc_feature    14103..14116
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.96"
                     /tool="antismash"
     gene            14156..15124
                     /locus_tag="ACTIVE_RS41875"
                     /old_locus_tag="ACTIVE_8401"
     CDS             14156..15124
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012850887.1"
                     /locus_tag="ACTIVE_RS41875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8401"
                     /product="CapA family protein"
                     /protein_id="WP_173100141.1"
                     /transl_table=11
                     /translation="MTVTVALAGDTMLGRGVAEEIAVSGPHGLFAGDVRDAFHEADLAL
                     LNLECCVSDRGRPWDAPGKPFHFRAPPDAVEALLDLGVDCVTLANNHALDFGPDALADT
                     VEHLRAAGVRSVGAGRGVREAREPAVLEAGGLRVAVVGFTDHPADFAAGPDRPGVALAD
                     LGHGVPAWPAEEIRALARDHDAVLVMPHWGPNMTGEPLRYVRRAAQDLVDAGASLVAGS
                     SAHVFHGVAWPVLFDMGDFIDDYVVSDLLRNDLGLLFLVTLGRGGPSRVEAVPLRLDFA
                     RTRLAGPADRAWIFDRFAAACAEFGTAVTVENDRLVVAAPA"
     misc_feature    complement(14205..14219)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(15132..16280)
                     /locus_tag="ACTIVE_RS41880"
                     /old_locus_tag="ACTIVE_8402"
     CDS             complement(15132..16280)
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630637.1"
                     /locus_tag="ACTIVE_RS41880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8402"
                     /product="nitronate monooxygenase family protein"
                     /protein_id="WP_173100142.1"
                     /transl_table=11
                     /translation="MNTEVCATFGIEFPLFAFSHCRDVVAAVTNAGGFGVLGAVAYTPD
                     RLEEELRWIDEHVGGRPYGVDVLVPAKIDESAERAGRGEGGLGTMLAAVPQEHWDFLIG
                     LFAKYDVPLPDFEKAKKSNTRGGTQVTKEGATELIDVSLAHPIGLIASALGTPPPVMVD
                     KAKAAGIPVAALVGTSEHARRQVAAGVDLVIAQGGEAGGHTGEISTMVLVPEVVDTVAP
                     VPVLAAGGIATGRQMAAALALGASGVWCGSVWLTTEEAETAPAVKEKMLAATSRDTIRS
                     RSRTGKPARQLRSAWTEEWEGPDSPGPLGMPLQMIVAEGAMRQITKVAESGNPGARALA
                     NYFVGQCVGLMNTVKPARQVVYDMVEEFAEAVDRLNAITSAD"
     gene            complement(16331..16732)
                     /locus_tag="ACTIVE_RS41885"
                     /old_locus_tag="ACTIVE_8403"
     CDS             complement(16331..16732)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853169.1"
                     /locus_tag="ACTIVE_RS41885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8403"
                     /product="OB-fold domain-containing protein"
                     /protein_id="WP_173100143.1"
                     /transl_table=11
                     /translation="MEIGVLRRDGRTDPFFDGTAAGKLVIKRCEACDRWYAPDAGGCPE
                     CGEEDLAWADASGEAVLVTWTATHGRPAEDGTVPPPVHLALVELAEGPWMYARLAGVTG
                     GALCEGLPLRASFEHPDEGESYVLFRPAG"
     gene            complement(16736..17926)
                     /locus_tag="ACTIVE_RS41890"
                     /old_locus_tag="ACTIVE_8404"
     CDS             complement(16736..17926)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630635.1"
                     /locus_tag="ACTIVE_RS41890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8404"
                     /product="thiolase family protein"
                     /protein_id="WP_173100144.1"
                     /transl_table=11
                     /translation="MNAAIAGLGMTELGRVYGRSPRRLAADAVRLAAADAGLGLADLDG
                     LLVSHGMGGSPGIELADTLGLRDLRLLTQMNAFGATAGAMVAHAAMSVMSGAATTVACV
                     FADAPLKPKQSAGSAYNRSAPSGSGVAPGKAEWYGYGGMTAALGLRSVNSFYALAAQRH
                     MSRYGTTSEQLGAIAVSTREWATRNPLAQMREPITIADHQASRWVSEPLHLLDCCLVSN
                     GAIAVIVTSADRARDLARPPVHLWGWGQGHPGHRKERGSDFGLTTGAVSSGATAMKMAG
                     ITPSDVDVCELYDCYTYTVLVSLEDYGFCAKGEGGAFAASGALGPGGSLPTNTGGGQLS
                     AYYMWGFTPLSEAVIQARGDGGERQAPRNDVVLVSGNGGILDHHSTLIVSPHPKGA"
     gene            complement(18003..18974)
                     /locus_tag="ACTIVE_RS41895"
                     /old_locus_tag="ACTIVE_8405"
     CDS             complement(18003..18974)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891666.1"
                     /locus_tag="ACTIVE_RS41895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8405"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_173100145.1"
                     /transl_table=11
                     /translation="MSAEPHVVAVLALDGVVAFDLATPGQVFGTTTTADGVPLYDVRIC
                     TPPGGARTSAALGRMRVDAPYGLDALAMADTIVVPGHEGVADDPPGEVLDALRSAAARG
                     ARIASICVGAFVLAAAGLLDGHRATTHWHYARALARRYPRVEVDPTVLYVDNGQVLTSA
                     GVAAGVDLCLHIVRRDHGSAAAARTARRIVMPPQRDGGQAQFIRHDEPPDGGAALQPTL
                     AWLEANLHRPLTLDEIARQAACSVRTLTRRFREQAGTTPQQWLSHARVRRAQQLLEDTD
                     LPVERVAAAAGFGSPVTLRAHFARRVGASPLAYRGAFRARSE"
     gene            19076..19729
                     /locus_tag="ACTIVE_RS41900"
                     /old_locus_tag="ACTIVE_8406"
     CDS             19076..19729
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014069.4"
                     /locus_tag="ACTIVE_RS41900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8406"
                     /product="HD domain-containing protein"
                     /protein_id="WP_173100146.1"
                     /transl_table=11
                     /translation="MSDRFAEFSLPDTDLTRKAYDLLFATGTPALAHHSVRTYLFARAF
                     GEAGGLRAGDDYDDEALFLASVLHDLGLTERGNGGHRFEVDGADLAAEFLTANGLDAAR
                     VRVVWEAIALHTSRGIAHRMRPEIALTHAGTGADIAALGAERLPAGVAERAHAAFPRLE
                     PGCGLTEIIVGQVEADPAKAPLGSLPYELARQAGAAVPDLRWTDLIAAAWPGTP"
     cand_cluster    19186..29581
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    19186..29581
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[24185:24581](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(24186..24581)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="2"
     gene            complement(19993..20775)
                     /gene="ehuA"
                     /locus_tag="ACTIVE_RS41905"
                     /old_locus_tag="ACTIVE_8407"
     CDS             complement(19993..20775)
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transport
                     [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630634.1"
                     /locus_tag="ACTIVE_RS41905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8407"
                     /product="ectoine/hydroxyectoine ABC transporter
                     ATP-binding protein EhuA"
                     /protein_id="WP_246343235.1"
                     /transl_table=11
                     /translation="MPHGDAPGIRFEKVVKRFGSNTVLRELDFAVEPGERVTLIGPSGS
                     GKTTILRLLMTLEKLDDGVIWIGDDTLWHMDKGGRRVAANQRHLHEMRKQVGMVFQQFN
                     LFPNMNVLRNLTEGPVRVLGVSKDEAVERARGLLDMVGLADKENAHPSQLSGGQQQRVA
                     IARALAMQPKVLLLDEVTSALDPELVVGVQDLLRDIARESDLTMLCVTHEMNFAKDISN
                     RVLMFDQGQIVEEGPPDRIFGEPAEQRTREFLQAVLAS"
     gene            complement(20894..21547)
                     /gene="ehuD"
                     /locus_tag="ACTIVE_RS41910"
                     /old_locus_tag="ACTIVE_8408"
     CDS             complement(20894..21547)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transport
                     [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuD"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630633.1"
                     /locus_tag="ACTIVE_RS41910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8408"
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuD"
                     /protein_id="WP_173100148.1"
                     /transl_table=11
                     /translation="MNWDWNYTGDIIPDLLDGLRYTVIATLAGYVIAVLLGLVWAMLRR
                     TPNVVVSQTVRWVTEFIRSTPLIPQLYFVYYVLPSWGLTIGSLTAGIITLGIHYSTYTA
                     EVYRAGISDIPRGQWEACTALNLPRSRVWLDVILPQAIRRVIPTLGNYLIAMFKDSPLL
                     LAINVTELLMSAYQVGSRSLRFLEPITLVGLLFIVVSVISSILVRRLERRYATN"
     gene            complement(21547..22263)
                     /gene="ehuC"
                     /locus_tag="ACTIVE_RS41915"
                     /old_locus_tag="ACTIVE_8409"
     CDS             complement(21547..22263)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transport
                     [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuC"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657166.1"
                     /locus_tag="ACTIVE_RS41915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8409"
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuC"
                     /protein_id="WP_173100149.1"
                     /transl_table=11
                     /translation="MSQVLDSYHQWLEGAWLTFRLTVFGGVLALVLALLFGLAGTARSG
                     WVRALNRVYVEFFRGTATLVLLYWFFYALPLVGLRFTTLFAAVLALGMNVGAYGAEVVR
                     GSIKAVPKAQYEATIALNFTPAQRMRRVLLPQAFALMLPPFGNLLIELMKGTAIVSLVG
                     LVDITHVSKNVQGSTGQTVWSFTVALVLYFVIAQVLQLFVRYAERRVDRMLGRRSSREP
                     DLGTVAAGAPGAGVAG"
     gene            complement(22267..23160)
                     /gene="ehuB"
                     /locus_tag="ACTIVE_RS41920"
                     /old_locus_tag="ACTIVE_8410"
     CDS             complement(22267..23160)
                     /GO_component="GO:0009897 - external side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033294 - ectoine binding [Evidence IEA]"
                     /GO_function="GO:0033295 - hydroxyectoine binding [Evidence
                     IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transport
                     [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630631.1"
                     /locus_tag="ACTIVE_RS41920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8410"
                     /product="ectoine/hydroxyectoine ABC transporter
                     substrate-binding protein EhuB"
                     /protein_id="WP_173100150.1"
                     /transl_table=11
                     /translation="MTSSRRDFLRTAVLLSAAVPLAAAGCSTTDPDKEVSGGGTLDKAK
                     KAGKITVGFANEAPYGYTDKDGKLTGEAPELARAVFKKLGIDKVEGVQVDFGGLIGGLN
                     AKRFDAIAAGMFITPERCASAAFANPEYVAKSAFMVPKGNPKNLKNQNDPAKAGVRVGV
                     LTGAVEQGYAEKSGVKKSDIKTFQDQASAYEGLKSGRIDCIWLTRISLADLLSKHQDGK
                     YEVTDAFTPVIEGKEQLGAGAFVFRKADSDLLNAWNTQLAALEKSNQLLPILQPFGFTQ
                     AEMPRPEDTAAKFCQG"
     gene            complement(23281..24189)
                     /gene="thpD"
                     /locus_tag="ACTIVE_RS41925"
                     /old_locus_tag="ACTIVE_8411"
     CDS             complement(23281..24189)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630630.1"
                     /locus_tag="ACTIVE_RS41925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8411"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_173100151.1"
                     /sec_met_domain="PhyH (E-value: 2.7e-35, bitscore: 121.6,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIIESHPSIDDAYPTRKAAEAALLYRQDPVVYGGPGDGPIDAAT
                     LDSFERDGFLSVEQLIAPEEVEDYRAELRRLASDPQILADERTVTERGSDEVRSIFEVH
                     KISEVFGRLVRDPRVVGRARQLLGSDVYVHQSRVNYKPGFTGKDFYWHSDFETWHAEDG
                     MPRMRAVSISIALTENFVHNGGLMIMPGSHKTFVACVGETPADHYKESLRGQEIGTPDP
                     NSLSILADKHGIELFTGPAGSATMFDCNCMHGSNGNITPFPRSNVFVVFNSVENTCVEP
                     FSAPAPRPPFIGARDFTPVRD"
     gene            complement(24186..24581)
                     /locus_tag="ACTIVE_RS41930"
                     /old_locus_tag="ACTIVE_8412"
     CDS             complement(24186..24581)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657163.1"
                     /locus_tag="ACTIVE_RS41930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8412"
                     /product="ectoine synthase"
                     /protein_id="WP_173100152.1"
                     /sec_met_domain="ectoine_synt (E-value: 3.9e-52, bitscore:
                     174.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSLDEIIGTERDVEAPTWCSRRLVLAKEGVGFSLHETILYAG
                     TETRMWYANHIEAVYCIAGEGELTNEETGEKHDIRPGVMYLLDGHEHHTLRAHTDVKTV
                     CVFNPPCTGREVHDENGVYPLLTEEDA"
     gene            complement(24635..25897)
                     /gene="ectB"
                     /locus_tag="ACTIVE_RS41935"
                     /old_locus_tag="ACTIVE_8413"
     CDS             complement(24635..25897)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (23-358). E-value: 5.2e-75.
                     Score: 244.5. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS41935_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657162.1"
                     /locus_tag="ACTIVE_RS41935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8413"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_173100153.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.9e-75, bitscore:
                     253.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVFARMESEVRGYCRSWPAVFRTAQGSHITDENGRTYLDFFAGA
                     GTLNYGHNNPQLKRRLMDYLASDAIVHSLDMYTTAKREFLERFNEYVLEPRGLDYKVQF
                     PGPAGNNSVEAALKLARKYTGRETVVSFTNAFHGMTLGALAVTGNSMKRTGAGVPLGHG
                     VAMPYDNYLDGRTPDFLLFDTMLDDSGSGLDKPAAVIVETVQGEGGINVATAEWLRGLQ
                     DLCRRHDILLIVDDVQMGCGRTGPFFSFEEAGITPDIVCLSKSLSGYGLPFAITLMKRE
                     LDVWEPGEHNGTFRGFNPAFVTAVAALEDYWTGQGMEKQTLAKGQQVQTALEEIALAHA
                     GAIDTVRGRGLAWGLVMKDPETAPQVCAEAFSRGLLMETSGPEGEVVKLLPPLTTTETE
                     LAHGLEIIAESVDAVRTKVSV"
     aSDomain        complement(24824..25828)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS41935_Aminotran_3.1"
                     /evalue="5.20E-75"
                     /label="ACTIVE_RS41935_Aminotran_3.1"
                     /locus_tag="ACTIVE_RS41935"
                     /protein_end="358"
                     /protein_start="23"
                     /score="244.5"
                     /tool="antismash"
                     /translation="TAQGSHITDENGRTYLDFFAGAGTLNYGHNNPQLKRRLMDYLASD
                     AIVHSLDMYTTAKREFLERFNEYVLEPRGLDYKVQFPGPAGNNSVEAALKLARKYTGRE
                     TVVSFTNAFHGMTLGALAVTGNSMKRTGAGVPLGHGVAMPYDNYLDGRTPDFLLFDTML
                     DDSGSGLDKPAAVIVETVQGEGGINVATAEWLRGLQDLCRRHDILLIVDDVQMGCGRTG
                     PFFSFEEAGITPDIVCLSKSLSGYGLPFAITLMKRELDVWEPGEHNGTFRGFNPAFVTA
                     VAALEDYWTGQGMEKQTLAKGQQVQTALEEIALAHAGAIDTVRGRGLAWGLVMK"
     gene            complement(26049..26597)
                     /gene="ectA"
                     /locus_tag="ACTIVE_RS41940"
                     /old_locus_tag="ACTIVE_8414"
     CDS             complement(26049..26597)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657161.1"
                     /locus_tag="ACTIVE_RS41940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8414"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_173100154.1"
                     /transl_table=11
                     /translation="MAPQHLESQTRRPDPDETTVDVQLQEPSLTDGPELWRIARDSKVL
                     DVNSPYSYALWCRDFADTSVVARDGGRACGFVTGYVRPSRPDTFFVWQVAVDQAHRGQG
                     LARRMLDRLGDRLTARGHRYMEATVTPDNKASEAMFASFARDRGCALTREPLFEAEHFP
                     GGGHEPEVLFRIGPLGAAT"
     misc_feature    26860..26875
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    complement(26989..27004)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            complement(27272..28234)
                     /gene="pip"
                     /locus_tag="ACTIVE_RS41945"
                     /old_locus_tag="ACTIVE_8415"
     CDS             complement(27272..28234)
                     /EC_number="3.4.11.5"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030163 - protein catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (39-301). E-value:
                     6.5e-37. Score: 119.4. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS41945_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="pip"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853167.1"
                     /locus_tag="ACTIVE_RS41945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8415"
                     /product="prolyl aminopeptidase"
                     /protein_id="WP_173100155.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.2e-10, bitscore:
                     38.9, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 3.1e-32, bitscore:
                     111.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELRTLYPPIEPYDSGLLDVGDGNQIFWEVCGNPDGKPAVMLHGG
                     PGGGCSAAHRRQFDPERYRIVLFDQRNCGRSLPHAKDPDVSLESNTTWHLVADMERLRE
                     HLGIERWLVFGGSWGSALALAYAQTHPERVTEMVLRGIFTLRPFELYWFYQEGASLIFP
                     DLWEKYVEPIPEDEREDLMSAFNERLNSPDRDVRVAAAKAWATWEGSTLTLRPDPELAE
                     GFGEPDYAVAFARIENHYFVNEGFFEDEQLIRDVDKIRHIPAVIVQGRYDVCTPAATAW
                     DLHRAWPEADFHIVDDAGHAYSEPGILHRLVEATDRFAG"
     aSDomain        complement(27332..28117)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS41945_Abhydrolase_1.1"
                     /evalue="6.50E-37"
                     /label="ACTIVE_RS41945_Abhydrolase_1.1"
                     /locus_tag="ACTIVE_RS41945"
                     /protein_end="301"
                     /protein_start="39"
                     /score="119.4"
                     /tool="antismash"
                     /translation="VMLHGGPGGGCSAAHRRQFDPERYRIVLFDQRNCGRSLPHAKDPD
                     VSLESNTTWHLVADMERLREHLGIERWLVFGGSWGSALALAYAQTHPERVTEMVLRGIF
                     TLRPFELYWFYQEGASLIFPDLWEKYVEPIPEDEREDLMSAFNERLNSPDRDVRVAAAK
                     AWATWEGSTLTLRPDPELAEGFGEPDYAVAFARIENHYFVNEGFFEDEQLIRDVDKIRH
                     IPAVIVQGRYDVCTPAATAWDLHRAWPEADFHIVDDAGHA"
     misc_feature    complement(28539..28554)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     misc_feature    complement(28883..28897)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 ggccgtggtc ggcggccagc agccgcagca tctcgccgac gacgtcctcc tcgacgccga
       61 cgccctcggc ggacggcccg gccgcgggcg cgccggggga gggctcggcg gacggcgcgt
      121 ccgggcggaa ccggtccagc tcccggtacc gctgcgggac gtacagcgac ggcgggtaca
      181 gcccgcccgc cgacagccgc gcggtctgcg ccgtcacgta ctccgacagg tccagcagcc
      241 cctggaactc ggtgaggctg cggacccgga tgccgcggcg cagtgcgtcg tcgcgcagcg
      301 accgcggcgg cggcgggccg aggtagacca gctcggagcc gtggtcggcg ccgtcggcgt
      361 gcacgtgccg gacgaacgcg tccacgtccg cctcggtcac ctgcccgacg tgcgcgccga
      421 tccggtactg ccggacgaac ccgtcctcca ggtgggtgag cagcaggtgc ggcgggtcgg
      481 cgcggccgtc ccgcgcgggc gggacgacgc gccggatcgt cgcgcgctcg aaccgggtct
      541 cgcacgcctc ggtgagccgg tccagcagcc gggccgtggg gtcgggcgcc gggtcggcgg
      601 cgtggtccgc cgggccgccc gcgccgtccc ggccgccggg gccgagctcg gggacgggac
      661 cggcgggcgc cgcctccgcc ttgggcggga acgttccggt ggtcttcgac caggcgaccg
      721 cgaggtgctc ggcgccgcgc ttcgcggcgt cctcggggat ccaccgctcc aggccgtccg
      781 gccggaccac gacggtctgg tgccggccgg gcccgagcgc cgggacagcc gggacgccgg
      841 agccgagcag cggcacggcg ccgaagtcgg actcggtgcc ctggaagaac aggttgaggt
      901 ggccgccgag cagcgtctcg acggtctcgg ggtcgcgcag cgcgcccggc tcgcccgcga
      961 tgggggtgtg ctcgatcgcg ccgagccgca gccatccctc gtcctcgaag tggcggagcc
     1021 gctcgttgaa ccacgccgcc tgcgcctgcc cgacccgccc gtaccggtcc tcctcgcggt
     1081 gcgactgcgg cagcgtcgag ttgagcccgg ccacgacgac cttcaggtcg gggacgggga
     1141 acagcgtcca cggctgcgcg ctgtcgaaga tgagcgagtc gaggccctgg tagaactcct
     1201 tgaacaggtt cgcgaagtgc cgccacttcg gccagtaggg cggctgcggc tcgatgtcgt
     1261 cggcctcgca gctggagaag tacgcctggc acgccgcccg cgtcacgtcg tgcgtgcccg
     1321 gcaccaccac gacgcgctgc gcctccaggc cgagcagggc gcgcaggctc gtcaggaacg
     1381 acagcgcctc cgcgaactcc ttgcggctgc cggagtgggt gaggttgccg gtgacgacca
     1441 gcaggtcggg gcgggggacg ccggcgtcgg cgagccgcgt cacgtcgctc cagatgcggt
     1501 cctgcagctc tgccgccgtc gtcggctcgc ccggctcggc gagcgtccgg ccgaacctcg
     1561 gccccgacac gtgcaggatg ctcagccggt cgcggggctc ctcggcgccg tgcgcggacg
     1621 ggaacgccgg ggccgccacg ggcgcgcggc gcgcgggccg ctcgcccgtc gcctccggcc
     1681 gctgcggtcc ggcgggcccg tcgccctcca ggtggcccac gatcggcgcg gggccgcccg
     1741 cggcccgctg cccgccgacc tgtccgccgg ggaagcccgg gccgtccgag gggcgcgcgt
     1801 ggccggccag cgcctcctgg atgcgccgca tcagcagccc gcgcgcctcg tcggggtcct
     1861 cgatcccgac gaggtcgacg taggtgatcg tcgacagcag cccgtcgatc gggcagtcct
     1921 cgatccgcac cgtgacgagc ttgcgggccg ggtcgtcggg gtcggcccgc agcgccgcca
     1981 tccactccag ccggccgtac cgcgagcgca ggtagttgcg cgacagcacc gccaccacgg
     2041 ccttggcctc cgacagcccc cggtccatga agtcgatgaa gttcgtcccg ggcacgaagt
     2101 cccacgcctg catcatcgtc cggtgccccg ccgcctccag ctgccaggcg atccacgacg
     2161 cccaccgctc gtcggcgggg gagtagctga cgaagaaatc ggtggggcgc tcctgccgtg
     2221 aaaggccgcc ggggggagtc atgccgccag tatcgcgcct gggacggcga tctccagcgc
     2281 atccggcccg gtaagtcgcc gccgttcgcg gccgcccggc ggcgcggcca tcggggtgcg
     2341 gggccgccgg tgcgcaatgg gcccggcggg gcgcggcggg ttatgggatc atggcgcgcg
     2401 tgtcgccccc gatcgagacc gtccgccgcg cggcccgctc gctgggcgtt ctcgactggg
     2461 tccgcatcgg cgtgctggtg ctcggcctgg tgttcgtcgc caccggcctg ctgcccgccg
     2521 actccgcgcg ctccagcctc ggacgcatcg cgccgctgct gctgttcctg ttcgcgatca
     2581 tcgtgctggc ggagctgacg aaggaggcgg gcgtcttcga cgccatcgcc cagcgggtgg
     2641 cgcgcgccgg gcgcggccgc tacgcggcgc tgttcctgct gtgcgtggcg ttcgcgtcgg
     2701 tcaacaccat cttcctcaac ctcgacacga ccgccgtact gctgacgccc gtcatgctcg
     2761 cgctcgcggc gcgcgcgcgg atcgcggctc tgccgctcgc catgacgacc gtgtggctcg
     2821 ccaacaccgc cagcctgctg ctgccggtct ccaacctgac gaacctgctc gccgccgacc
     2881 gggtcgccct ggagaccccc gagttcgcgg cgcgcatgtg gctgccgcag gcggccgtcc
     2941 tggccgtcac catggtgctg ctgtgggtgt tctactggcg gcgccgcatg cgcggggagg
     3001 aggcctacga cccgccggag cccgtccccg tgcgcgatcg ggtgctgttc tccacgaccg
     3061 gtatcgcctg cctgttcttc atcggggcga tcctcgcggg cgtccacacc gggatccagc
     3121 tcggcatcac cactaccatc gccgccgccg tggccgtcgc cgcgttcgcc gtccgcgaca
     3181 ggtccgtcct gcggcccacg ttgatcccct ggcagctgat ggtgttcgtc accgggctgt
     3241 tcctggtcgt ccccacgctg gagcgctacg ggctcgacga cgcgatgcgc gcgctcgtcg
     3301 gcaccgacga cggcgcctcg ggcgcgttcc gcgcggggtt ctcaggggcg ggcctgtcga
     3361 acgtcctgaa caacctgccc gcctacgtcg cgggggagtc cgccgtgccc gcggccaaca
     3421 aggaccagct gctctcgctg ctcgtcggca cgaacgtggg gcccgtcatc accccgtggg
     3481 ggtcgctcgc gacgctcctg tggttcgagt ggtgccgccg gtggaacgtc cgggtcccga
     3541 tgcgcaagtt cgtcctgacg ggggcggcgc tggcggtcct cggctgcacc gccgccgtcg
     3601 ggaccctgct catcacgagc tgaccccgct tctcacccgc cggccggccg ggtcacaggg
     3661 cgcttccggc ggccgtctcc agcagccggt cgagcagctc gggacgcgcc gccacgaagc
     3721 tcagctccga cggcggccgg tcgatgccca gctcgtacgg ggacccgtcc aggcggcgca
     3781 gctccgcgcc cgcctccgcc gccagcagcg cccccgccgg aaggtccacg atctccggca
     3841 ggtacccgac gatgccgtcg atgtcgccgc gcgccagcat cgcccacccg accagcggcg
     3901 cccacagctg cagcatccgc gcgcacccgg cctccacccg cgaccgcagc cggaacgccg
     3961 cggcgtcgcc cggacccacc tggtgcccct gcgtccacgc cagcaccggg ttccgctccc
     4021 gcccgggacg cggatgctcg ggcagcgtga gcggcgcccc gtcggggccc tgcgcgccgc
     4081 cgccgtgcag cgccgaccac gtgcgtcccg tcaccgggtc gtggacgacg cccagcaccg
     4141 gctccgcgcg cgcacacagc gcaaccccca ccgcgtacac cggcatcccg atggcgacat
     4201 tgttggtgcc gtccagcggg tcgacgagcc acaccatctc ctcgcccggc gcgccgtcca
     4261 ggatcccgga ctcctccgcg atgatgcggt gccccggata cgtcgcgcgc agccgctcca
     4321 ggatcagcgc ctccgcggcc gtgtccagct ccgtcaccac gtcccccgcc gcgcccttgg
     4381 ggcggacgtc caccggcccg tccacccggg agcgcagcag cgtccccgcc gcctccgccg
     4441 cctcgaccgc cacccgccgg gcctccgcga gatcgaccgg gcgggccggt gacggagtgc
     4501 tggttctcat cgggcctctc cagtcgttga cgggcccgcc taccggcggg ccgagcggtg
     4561 ccggcacccg tgcgggccgg aggacggagg ttcgccgggc ggctccgcgg cccccgcggg
     4621 accgggacgc gccgccgcga tccggtgcgc cgagcgccgc agcgcccgca ccgtctcgcc
     4681 gggatcgcac cgggcgcgca gcacccggtg cgtcgggacg tccagcggtc cgagggacag
     4741 gtcgccgccg ccgggcgtct gccgccccag cgccaccgtc gccgcgtcca ggccgtcctc
     4801 gatgagcgtg ctgtggaaca cccccgcggg cagcgtgtac gactccccgg tgcggtgcgt
     4861 cgccgaagga ccgggacggt accggacggc ccggcccgtc gccctgagct cgtccacgtc
     4921 gccgctgctc acgacctcga acacctgccc ggcgccctcc gccgcggcgc cggggccctc
     4981 cagcacgtcc atgcgcacgt tccggaccgt cccgtacagg acgaagctga gcaggtccca
     5041 gctgtggcag tggaccggcg acgtcgtcga cgggacgggc cgcacctccg gcgtccagat
     5101 gtgcaggcac acgccgaggt caccgctgcg ctccaccgga aggcacagga accccagggg
     5161 gtggcggacc gccgcgacgg gcgagcggcc cgcggccgcg tcctccagga cgcgcccggc
     5221 ccacgccggc agggtccgcg cggcgcggcc ggcgcggatg tccccctgga tctcctcgta
     5281 cctcatcccg tcccgtcacg ccctccccgc ggccggtggc acggcccggt cactcgtacg
     5341 ggtccttcgc gcgcagcgcc ttgcggatga tctcgatgac gtcccggtcg gtgtaggagt
     5401 gcgcgagcgg gatcgcgatc acctcgaaga gccggcggac ctcctcgacg gtcggctcgt
     5461 cgtccagcgg cgccagcctc gcctgctcga ccgggacgcg gcgcgcctgg tccaggctcg
     5521 tctgcagctc cgcgctcacc cagctgtagt agaacttgtc gttgtcgacg accagcgcct
     5581 cgccgcgcgg gtcgtcgcgg gtcaccacca gccgcgacgc cgcgaggtcg tagcgcagcg
     5641 tcgtcatcgt ctgcgccagg ccgatgtcga tgtcgagcat cccgaagcgc tgcttgtgcc
     5701 agcacgccgc cagcagcgtc gcgtacgcct ccttgcgggt gcgctccagc gtccacttct
     5761 cgcccgtcgc gtccggcgcg tccgacaccg agcggcggtg ccgcgcgtag gcctcgcaga
     5821 cctccacgtt ggtggggtcg aggatctcca gccggaacag cagggtgcgg cggtcccggc
     5881 gggcggccgc gacgcactcc ggcagcgtct tggcgcggat gtaggtgccg gtgccgccct
     5941 tgaagaacca ccggtcggtg tcgcgccgcg cctcctccag cacctgcgcg acctgcccgc
     6001 cgccgatcac ccgcacgacc gccgtctcgt ccagcgcccg cttggtgccc gccaggacgc
     6061 cctcgaactc ctcgatgtgc gccagccggc cgctcagctc gtcgagcgtg gacgcggacg
     6121 cccgcagcgt gtcgcggacc tcggcctcca ccgggatgcg gcggccccgg tcgcgcagca
     6181 ccgaggtggc cagcagtgcg atcaccgcga ggatcgcgct ctgcgtgatc tcgttctcgt
     6241 gcggcaggtt caccccgagc ccgagcaccg cgacggtgat cgccagcacc agcgcgatga
     6301 aggcgtcggc gttcttcccg agccagttgg cgaagcgggt catcgtctgc ggccatcccc
     6361 gtcctagtcg gcgccgtcat cgtaaccaca gcaccgggag ggcgggaaag ccctgcggcc
     6421 ggggcgtcgc gggctccgcc cggccacacc cccgtcacct gcgccgccgc cacccggccg
     6481 gcggagccgc cgccggagcg gcgtcgggcg cgtcacccgg cctcacatgg acggttccgg
     6541 tcccccggcc tgcctatagg ctcgtgacat gcacctgggg gcctggtggt cggcggcgtg
     6601 gccgacgcgg cgttcacgtg tgctggacgt cgccctggcc gtgaccttcg ccgtcctgga
     6661 cggcctcttc ctgtggttct ccccccagca cttctggctg ccgcacaccg tcacctcggc
     6721 gtgcagcgtc gtcctcggcc tgaccatcgt ggtgcggcgc cggcaccccg tcgcgctggc
     6781 ggtcttcgcg acggtgttca gcgcggtgac gggcggcggc gcgttcgtga tcctcgtgat
     6841 cctgtactcg ctggccgcct acgcggcgtc ccggcgcgtc gtcctggcga tcgccgcgct
     6901 gaactacgcc gtgggcctcg ccttcccccc gcccaccgcc agcagggaca gcttcctcgt
     6961 ccaggtgatc ttcggcgtca cgttcaccgt ggtccccgtc ctgctcggcc tctacatggg
     7021 cgcgcgcaag cagctgctgg tgtccctcca ggaacgggcg gcgcgcctgg aacgcgagca
     7081 gaacctcctc gccgagcgcg cgcggggcga ggaacgcacc cgcatcgccc gcgagatgca
     7141 cgacgtggtc gccaaccgca tcagtgtcat ggtcgtccac gcgggcgcgc tcaaggccgt
     7201 cgccgcccgc gaccccggac gggccgccga gaccgccggc gtcatcggcg acatgggacg
     7261 ccaggccctg gaggagctgc ggcacgtcat cggcgtcctg cggcagggcg aggaggcgct
     7321 cccgcaggag gccgtcaccc tggagcacgt gcgggagctg atcggccagt ccggcgcggc
     7381 gggcctccgc gtcgtgctgt ccgtccgcgg cgtggagcgc cccatgccga ccgcggtggg
     7441 ccggacgctc taccggctcg tccaggaggc cctgaccaac gtgcacaagc acgccggcgc
     7501 cgccgacacc cgcgtcgacc tcggcctgct ccccgaggcg atcgaggtgg agatcgccaa
     7561 cgacccgccc accgcgccgc ccgcgcacgg cctgccgagc ggcgggcacg gcctggtcgg
     7621 gctgcgcgag cgggtcaccg ccctcggcgg cagcttcgag gccggcccgc gcggcggcgg
     7681 ctaccgcgtc agcgcccggc tcccgctgcc cgcctcctga ccgtttaagc gttctgacct
     7741 gcggaaatat cggacggtcc gcgattgtcg tacctgctgc atagagtggg cggcaagcga
     7801 gggaaagacc agggggagag gcgatcatgc ggccgatcac ggacctgcgg cgccgcgtgg
     7861 cgccgttcga ggtcgtcacc gagatgacgc cgtcgggcga ccagccggcg gcgatcgccg
     7921 ggctggccga gcgggtcgag cgcggcgaca aggactcggt gctgctcggc gccaccggca
     7981 ccggcaagac cgccaccatc gcgtggctgg tcgagaagct ccagcggccc gtcctggtca
     8041 tgcagccgaa caagacgctg gccgcgcagt tcgccaacga gctgcgcgag atgatgcccg
     8101 gcaacgccgt cgagtacttc gtgtcgtact acgactacta ccagcccgag gcgtacatcc
     8161 cgcagaccga cacctacatc gagaaggact cctcgatcaa cgacgaggtc gaccggctgc
     8221 ggcactcggc gaccaactcg ctgctcaccc gccgcgacac cgtcgtcgtc gcgtcggtgt
     8281 cgtgcatcta cggcctcggc accccgcagg agtacgtcga ccggatggtc cggctgcgcg
     8341 tcgggcagga gatcgagcgc gacgacctgc tccgccagct cgtcggcatg cagtacagcc
     8401 gcaacgacct ggcgttcacc cgcggcacct tccgggtccg cggcgacacc atcgagatca
     8461 tcccgcagta cgaggagctc gccgtccgga tcgagatgtt cggcgacgag atcgagaagc
     8521 tcgccaccct gcacccgctc accggcgagg tcatcaccga ggacgaggag ctgtacgtct
     8581 tccccgcctc gcactacgtc gccggccccg agcggatgga gcgcgccatc cgcgacatcg
     8641 aggccgagct cgaggtgacc ctcgccgaca tggagcggca gggcaagatg ctggaggcgc
     8701 agcggctgcg catgcgcacc acctacgaca tcgagatgat gcgccaggtc ggcacctgct
     8761 ccggcatcga gaactactcg cggcacatcg acggccgcgg cgccggcacc gcgcccaaca
     8821 ccctcctcga ctacttcccg gaggacttcc tcctcgtcgt cgacgagtcg caccagaccg
     8881 tcccgcagat cggcgcgatg tacgagggcg acgcgtcccg caagcggatg ctggtcgagc
     8941 acgggttccg gctgccgtcc gcgatggaca accggccgct gaagtgggag gagttcctcg
     9001 accgcatcgg ccagaccgtc tacctgtcgg cgacgccggg cacctacgag atgaaccggg
     9061 tcaagggcga cgtcgtcgag caggtcatcc gcccgaccgg cctgatcgac cccgagatcg
     9121 tggtgaagcc gaccaagggc cagatcgacg acctcatcca cgagatccgg ctgcgcaccg
     9181 agcgcgacga gcgggtcctg gtcaccaccc tcaccaagaa gatggccgag gacctcaccg
     9241 actacctcct ggagctcggc atccaggtcc gctacctgca cagcgaggtc gacacgctgc
     9301 gccgcatcga gctgctgcgc gagctgcgcg ccggcgagtt cgacgtgctg gtcggcatca
     9361 acctgctgcg cgagggcctc gacctgcccg aggtgtcgct cgtcgcgatc ctggacgccg
     9421 acaaggaggg cttcctgcgc tccgagacgt ccctcatcca gacgatcggc cgtgcggcgc
     9481 gcaacgtctc cggccaggtg cacatgtacg ccgacaccgt caccccgtcg atggagcggg
     9541 cgatcgacga gacgaaccgg cgccgcgcca agcagcaggc ctacaacgag gagcacggca
     9601 tcgagccgac ggcgctgcgc aagcggatcg ccgacatcct cgactccctc gcccgcgagg
     9661 acgccgacac cgagacgctc atcggcggcg cggggcgcca gcagagccgc ggcaaggcgc
     9721 ccgtccccgg cctcgcgtcg cgcaccaagg aggtcggccg gcacgccgcc gacctggtcg
     9781 gcgagcgtcc ccgcgaggag ctggagggcc tcatcgagca gatgaccgag cagatgcacc
     9841 aggccgccgc cgacctgcag ttcgagctcg ccgcccggct ccgcgacgag atcaaggagc
     9901 tcaagcgcga actccgcgag atgaaggagg ccggcgtcaa gtaggccggg ccccgggaaa
     9961 acggctggcg atcaccggcg gccgcgcgga cgatcggggc atgcgcagaa cgggacccga
    10021 gggacgccgc atcgcctggg agaccgtggg gagcggcccg ccgctggtgc tgctgcacgg
    10081 gtccttcggc gaccgcggca cctggtggcc gggcgggcac gtcggcgcgc tggcggggga
    10141 gcaccggctc gtcctcatcg acgcgatcgg ccacggcgag agcgacgcgc cggacgaccc
    10201 ggccgcctac cggatcgacc ggcaggccgg cgacgtcctc gccgtgctgg acgccgaggg
    10261 cgccggcagg gcggcgttct ggggcgcctc gatgggcggc accatcgggt tccacctgct
    10321 ggcccgccac ccggagcggc tgacctgcct gatcgccagc ggcgcccatg cccgcgggct
    10381 cggggccgat cccgcggacg tcgagcggga ggccgcgttc tgccgcgacc ggggcgccgc
    10441 gccgttcgtc gaggcggtgg agcggcgggg cgcgctgccc ggctggatgc gcgacgcgat
    10501 gctggcgatc gccccggagg cgctcgccgc ccagaccgtc gggcttttcg agctgccgga
    10561 cgtcaccgca gcggtggccg aagcggaggt gccggtgctg ctgctcgccg gggacggcga
    10621 ccaccggctg ccggcgatcc gccgcaccgc ggaagcggtg ccgaaggcgt cgctgctgga
    10681 acttcccggg tgcgggcacc tggacgcgtt cctgcgcctc gacctgacct tgccggtggt
    10741 ccggccgttc ctgcggcggt acgcgaccgc gtgacgggcg ctaccgcgcg gtcgcggcgc
    10801 gggccatctc gaactgccgc tcgtccgtgc cgggacggcc gggcttcgcg gtgcccgtcc
    10861 tcgcgaagcc gtgccgggcg tagaggcgct ccgcgtgccg gttcccctcg aagacccaga
    10921 gcctcagctc ggcgaagccc cggtcggcgg tccagtccag ggcggcgcgg accaggaggt
    10981 cgccgacgcc ccggccgcgc gcggacggcg ccacccacat gccgacgagc tcggcagccg
    11041 cgccctcgtc ggggacgacg gcggccaggc cggccgggcc gtcgccggtc tcggcgagga
    11101 gggtgttgcg ggcggcgagc cggtcctgcc acacgctcgg cgcgaacgcc tcctcgcggg
    11161 cgagcgtcga ccagaaggcc gcgggggact cggtcaggga cgcgagccgg accgaccggt
    11221 acagagccca gtcgccggcc tccagcagcc gcaccgtcgc catgcccgac accgtcgcat
    11281 ccggccgccg ccgcggcaac cggttaccgg cggaaaagga ggggcggcgc gggcgcgcgg
    11341 cgttctacgc tcgcgggatg gagtacgacg tccgtcccgc gcggcccggc gacctgcccc
    11401 gcctgccggc gatcgaggac tcgggcgacc gcctgttcgg ggcgctcggg atcgtgttcc
    11461 cgccgcatcc gacggtcgcc gaggagatga tcgccaaggg cgccgagttc ctcgtggccg
    11521 gcgacccgcc ggtcgggttc gcggccgtcg aggaggtgga cggcgcgacg catctggagc
    11581 agatctccgt ccacgccgac ctcgtgggcc gggggatcgg cgcccgcctg ctgcgcgcgg
    11641 tgaaggaggg cgcggccggg cggggatctc cgggtgtgag cctgctgacg ttccgggacg
    11701 tcccgtggaa ccgcccctgg tacgcccggc acggcttcgc cgaactgccg cgggagcggt
    11761 gggggcccgg catccgggcc tactgggacg cggagatcgc ggccgggttg cacgagctcg
    11821 ggccgcgcct cgtcatgtgg gcgccgctgc cgccgcccgg gaccggatga ccgggtccgg
    11881 acgagccgcg gtccgcacgt aaggttggtg accgggaacg cgcgacgccc cgcccgcgtc
    11941 ccagtacaag atctacaacg taaaggcgga cgcccgggga gcgcggcgtc cgggttgcgc
    12001 aaggaggacg atgaccccgg ggtcctggcc gcgtcggctg cgcgagcgtc tcggcgaccg
    12061 cgggctcgcc gtcctcgtcc tggtggggct gctggccctc gccgtcgtcc cgctggtggc
    12121 gatgcccgcc gcgcggtgca agacgttcgg gagcggctgc ccgaagccga agccgccggt
    12181 gcgcgccgac ccggtcgtca cgcaggaggg ccaggtcacg ccgctccagg cggcgacgcg
    12241 cggcgcgtac gtcgcgctcg gcgactccta ctcggccggg gtcggcgcgg aggcgacggt
    12301 cgccgaccgc aacccgctca accggtgccg ccggacgtcc aaggcctact accacgaggt
    12361 ctcggcggcg ttccgcttcg ccaaggggtc ctcgttctgg gcgtgctcgg gcgccacgac
    12421 ggccgacatc ctgaaggggc ggtacggcga gccgccgcag ctcgaccgcg tcgacgccgg
    12481 cacgagcctg gtgacgatca gcatcggcgg caacgacgtc gggttctcca aggtgctcgg
    12541 tggctgcgtg atgcgcctgc cgtggagcca cagctgcacg gaccagggca aggacatcgc
    12601 cgaccggatg gcgaagctgc gcctggcgct gcccgcgctg ctggagaaga tcaccgacag
    12661 ggcgccctcg gcacgggtga tcgtgatggg gtacccgaag gcgttctccg aggtcaccgg
    12721 ggccggcggc gacaacatca ccgtgtcgga ccagcagtgg ctgaacgccc gcgcctacga
    12781 cctcggacgg ctcgtccggc agtcggtcgt cgaggcggac gcgcgggtcg tcgcgcggca
    12841 cggccggggg agcgtggagt tcgtcgacgc ctacagcgcg ttcgccggcc acgaggcggg
    12901 cagcgcggac ccgtacatga acggcctggc gctgaacctg tcggcgctgg aggccgagcc
    12961 gcgcagcttc catccgacgg cggccggcca gcacgcgctg gcgcagctgt tcatcgcgca
    13021 ggtcaaccgg ggccccggcc gcccgctgac ctgagacggc gcccgccacg ctgagcggcc
    13081 cgcgccgtcc tgaaacggct ttcgctgtcc tgaaacggtc atggtgcgcc gcacgtccgg
    13141 ccggacgtgc ggcgatgatc cgcgcccccc ggtgctgaga ggtccgtcac accgcgcgac
    13201 cttcaaaaag acatcggcgt ttgtttagct tgtggcgtcc cggtcgctcg aacccccgga
    13261 agtgagcccg atgcccaacg ccctccgcag gaccctcgcc gccgccctcg tcgccgccgg
    13321 cctgtccctg cccgccctcc ccgcccacgc cgacaccacc acgcccgtgc cgatcggcgg
    13381 cggctccggg atcgtccagc agctcaagca ggtctctccc ggcggcggct actccttcga
    13441 gctctgcacg ctgacggcca tcggccacga cgccgagggc aacctcgtgg gcctgaccaa
    13501 cgcgcactgc ttcctcgacg cggacggcaa caagctggtg ggcgacacgg tgtacgacaa
    13561 caccaccccg gccggcaccc ccgccgccaa cgcccccgcc accttcgact tcgacgccac
    13621 catggcgatc gggccgatcg gcaaggtcac ctacgtcagc gagcccaaca acctcctgtc
    13681 cggaggcccg aaggggctgg actacgcggt gatcaagctg gacccggcca aggtcacccc
    13741 cgccgcgacc gtcagcgccc ccaacggctc gacgacgatc gactccatcg gccaggtgcc
    13801 cggcttcggc acccggatgt gcaagatggg ccacaccacc ggcgtcacct gcggcatcac
    13861 cctcggcacc gacggcccct ggtacctgac ggcgatctgg acctcgccgg gcgactccgg
    13921 ttcccccgtc gtcaacggga ccgccctgac cggcacggcg ttcggcctgc agcacttcac
    13981 gccgatcacc agcattctcg ccgacatgaa cgcccgcggc ggcgtcggtg cgggcttcca
    14041 catcggctga cggcccccgc ttccaggcgc ctccccgcgg cggcggggag gcgccgcccc
    14101 gcagaacaat cggtcctcca ggacggggta ggacgactaa ggggggaggt gcacgatgac
    14161 cgtcacagtg gccctcgcag gagacacgat gctcggacgc ggcgtggccg aggagatcgc
    14221 ggtgtccggc ccgcacggcc tgttcgccgg ggacgtccgg gacgccttcc acgaagccga
    14281 tctcgccctg ctgaacctcg aatgctgcgt gtccgaccgc gggcgcccgt gggacgcgcc
    14341 gggcaagccg ttccacttcc gcgcgccccc ggacgccgtc gaggcgctcc tcgatctcgg
    14401 cgtcgactgc gtgaccctcg ccaacaacca cgcgctcgac ttcggcccgg acgccctcgc
    14461 ggacaccgtc gagcacctgc gggcggcggg cgtgcgcagc gtcggcgcgg gacgcggcgt
    14521 ccgcgaggcg cgcgaaccag cggtcctgga ggccggcggc ctccgcgtcg cggtcgtcgg
    14581 gttcaccgac caccccgcgg acttcgccgc cggcccggac cgtccgggcg tcgcgctcgc
    14641 cgacctcgga cacggcgtgc ccgcctggcc ggccgaggag atccgcgcac tcgcccgcga
    14701 ccacgacgcc gtcctggtca tgccgcactg gggcccgaac atgaccggtg aaccgctccg
    14761 ctacgtccgg cgggccgcgc aggacctggt ggacgcgggc gcctcgctcg tcgcggggag
    14821 ctccgcgcac gtcttccacg gcgtcgcctg gccggtgctg ttcgacatgg gcgacttcat
    14881 cgacgactac gtcgtgtcgg acctgctccg caacgacctg gggctgctgt tcctcgtcac
    14941 cctcggacgc ggcgggccgt cccgcgtcga ggccgtcccg ctccggctgg acttcgcacg
    15001 cacccgcctc gccggccccg ccgaccgcgc ctggatcttc gaccggttcg cggccgcctg
    15061 cgccgagttc ggcaccgccg tcaccgtcga gaacgaccgg ctcgtcgtcg cggcgcccgc
    15121 ctagcgccgc gtcagtcggc ggaggtgatg gcgttgaggc ggtcgacggc ctcggcgaac
    15181 tcctcgacca tgtcgtagac gacctggcgg gcgggcttga cggtgttcat caggccgacg
    15241 cactggccga cgaagtagtt ggcgagcgcg cgggcgccgg ggttgccgga ctccgccacc
    15301 ttcgtgatct gccgcatggc gccctcggcg acgatcatct gcagcggcat gccgagcggc
    15361 ccggggctgt ccggcccctc ccactcctcg gtccacgcgg accggagctg gcgggcgggc
    15421 ttgccggtgc gcgaccgcga ccggatggtg tcgcgggacg tggcggcgag catcttctcc
    15481 ttgacggcgg gcgccgtctc ggcctcctcg gtggtgagcc acaccgagcc gcaccacacg
    15541 ccggacgcgc cgagggcgag cgcggcggcc atctggcggc cggtggcgat gccgccggcg
    15601 gcgaggacgg gcaccggcgc gacggtgtcg acgacctcgg ggacgaggac catcgtggag
    15661 atctcgccgg tgtgcccgcc ggcctcgccg ccctgcgcga tgacgaggtc gacgccggcg
    15721 gcgacctggc ggcgcgcgtg ctcggaggtc ccgacgagcg cggcgacggg gatcccggcg
    15781 gccttggcct tgtccaccat gaccggcggc ggggtgccga gggcgctggc gatgaggccg
    15841 atcgggtgcg cgagggacac gtcgatcagc tcggtggcgc cctccttggt gacctgggtg
    15901 ccgccgcgcg tgttggactt cttggccttc tcgaagtcgg gcagcgggac gtcgtacttg
    15961 gcgaacaggc cgatgaggaa gtcccagtgc tcctgcggga ccgcggcgag catggtgccg
    16021 aggccgccct cgccgcgccc ggcgcgctcc gcggactcgt cgatcttggc ggggacgagc
    16081 acgtcgacgc cgtaggggcg gccgccgacg tgctcgtcga tccagcgcag ctcctcctcc
    16141 agccggtcgg gggtgtaggc gacggcgccg aggacgccga agccgccggc gttggtgacg
    16201 gcggcgacga cgtcgcggca gtggctgaag gcgaacagcg ggaactcgat cccgaacgtg
    16261 gcgcagacct cggtgttcat gtccccgacg ctaatggacc gaacgccatt cggtccaggg
    16321 ttcgcggcgg tcagccggcc gggcggaaca gcacgtacga ctcgccctcg tccggatgct
    16381 cgaacgaggc ccgcagcggc agcccttcgc acagggcgcc gccggtgacg ccggccagcc
    16441 gcgcgtacat ccacggccct tcggcgagct cgacgagcgc gaggtgcacc ggcggcggga
    16501 cggtgccgtc ctcggcgggc cggccgtggg tggccgtcca ggtgaccagg accgcctcgc
    16561 cgctcgcgtc cgcccaggcc aggtcctcct cgccgcactc ggggcagccg cccgcgtccg
    16621 gcgcgtacca gcggtcgcac gcctcgcagc gcttgatcac gagcttgccg gcggcggtgc
    16681 cgtcgaagaa cgggtcggtg cgcccgtcgc gccgcagaac gccgatctcc atcggtcagg
    16741 ctcccttcgg gtgcgggctg acgatcaggg tcgagtggtg gtcgaggatg ccgccgttcc
    16801 cgctgacgag gacgacgtcg ttgcgcggcg cctgccgctc cccgccgtcg ccccgcgcct
    16861 ggatgacggc ctccgacagc ggcgtgaagc cccacatgta gtacgccgac agctgcccgc
    16921 cgccggtgtt ggtgggcagc gacccgccgg ggccgagcgc gccggacgcg gcgaacgcgc
    16981 cgccctcgcc cttggcgcag aacccgtagt cctccaggga cacgaggacg gtgtaggtgt
    17041 agcagtcgta cagctcgcac acgtccacgt cggacggggt gatcccggcc atcttcatcg
    17101 cggtcgcgcc ggaggagacg gcgccggtgg tcagcccgaa gtcgctgccg cgctccttgc
    17161 ggtgccccgg gtggccctgc ccccatcccc acaggtggac gggcgggcgg gcgaggtcgc
    17221 gggcgcggtc ggcgctcgtg acgatcaccg cgatggcgcc gttggacacc aggcagcagt
    17281 ccagcaggtg caggggttcg gacacccacc gggacgcctg gtggtcggcg atggtgatcg
    17341 gttcgcgcat ctgcgcgagc gggttgcgcg tcgcccattc tctcgtggag accgcgatgg
    17401 cgccgagctg ctcgctcgtc gtcccgtacc gggacatgtg ccgctgggcg gcgagcgcgt
    17461 agaaggagtt gacgctgcgc agcccgagcg ccgccgtcat cccgccgtac ccataccact
    17521 ccgctttccc gggcgcgacc ccggaccccg agggggcgct gcggttgtag gccgagcccg
    17581 ccgactgctt cggcttcagc ggcgcgtcgg cgaacacgca cgcgaccgtc gtggcggcac
    17641 cgctcatcac cgacatcgcg gcgtgcgcga ccatcgcccc ggcggtggcg ccgaaggcgt
    17701 tcatctgggt cagcagccgc aggtcccgca ggccgagcgt gtcggccagc tcgatcccgg
    17761 gcgagccgcc catgccgtgg ctgaccagca gcccgtccag gtcggccagg ccgaggccgg
    17821 cgtcggccgc ggcgagccgc accgcgtcgg ccgccagccg ccgcgggctg cgcccgtaca
    17881 ccctgccgag ctccgtcatt cccagcccgg cgatcgcagc gttcattcgt cgcatccctc
    17941 cccgcatcgt caccgccacg gtaccgaaca gcattcggta ggcggggcgg cggggcggac
    18001 ggtcactccg agcgcgcccg gaacgcgccc cggtaggcca gcggcgacgc gccgacccgg
    18061 cgggcgaagt gggcgcgcag cgtcaccggc gacccgaacc ccgccgcggc cgccacccgc
    18121 tcgaccggca ggtcggtgtc ctccagcagc tgctgggcgc ggcgcacccg cgcatgcgac
    18181 agccactgct gcggggtcgt cccggcctgc tcccggaacc gccgcgtcag cgtccggacg
    18241 ctgcacgccg cctgccgcgc gatctcgtcc agcgtcagtg gacggtgcag gttcgcctcc
    18301 agccacgcca gcgtcggctg cagcgccgcc ccgccgtccg gcggctcgtc gtgccggatg
    18361 aactgcgcct ggccgccgtc gcgctgcggc ggcatgacga tccgccgggc cgtccgcgcc
    18421 gccgccgccg agccgtggtc gcggcggacg atgtgcaagc acaggtcgac gcccgccgcg
    18481 acgcccgccg acgtgagcac ctgcccgttg tcgacgtaca gcacggtcgg gtccacctcc
    18541 acccgcggat agcgccgcgc cagagcgcgc gcgtagtgcc agtgcgtcgt cgcgcggtgc
    18601 ccgtccagca ggcccgccgc ggccaggacg aacgcgccga cgcagatcga cgcgatccgg
    18661 gcgccccgcg ccgccgccga ccgcagcgcg tccagcacct cgccgggcgg gtcgtccgcg
    18721 accccctcgt ggcccgggac gacgatcgtg tccgccatgg ccagcgcgtc caggccgtac
    18781 ggggcgtcca cccgcatccg gccgagcgcg gcggaggtgc gcgcgccgcc cggcggcgtg
    18841 cagatccgga cgtcgtagag cgggacgccg tcggccgtgg tcgtcgtccc gaacacctgg
    18901 ccaggggtcg cgaggtcgaa cgccacgacc ccgtccagcg cgagcaccgc gacgacgtgc
    18961 ggttcagcgg acatggccag aacgtagcgc acatcggcag tccggacact ggccggtctc
    19021 ccgcccggca tcggacgatc gatggcgttc agcgcatccc ctcgaaggag cctcagtgtc
    19081 cgaccgtttc gccgagttct cgctgcccga caccgacctg acccgcaagg cgtacgacct
    19141 gctcttcgcc accgggacgc cggcgctcgc gcaccacagc gtccgcacct acctgttcgc
    19201 ccgcgccttc ggcgaggcgg gcgggctccg cgccggcgac gactacgacg acgaggcgct
    19261 gttcctcgcg agcgtcctgc acgacctcgg gctgaccgag cgggggaacg gcggccaccg
    19321 cttcgaggtg gacggcgccg acctcgccgc cgagttcctc accgcgaacg ggctcgacgc
    19381 cgcgcgggtc cgcgtcgtct gggaggccat cgccctgcac accagccggg gcatcgccca
    19441 ccgcatgcgc cccgagatcg ccctcaccca cgccggcacc ggcgccgaca tcgccgccct
    19501 gggcgcggag cgcctccccg ccggcgtcgc cgagcgcgcg cacgccgcgt tcccccgcct
    19561 cgaaccgggc tgcggcctca ccgagatcat cgtcggccag gtcgaggccg atccggccaa
    19621 ggcgccgctg ggctccctcc cgtacgagct ggcccgccag gccggcgccg ccgtccccga
    19681 cctccgctgg acggacctga tcgcggcagc ctggcccggc accccctgac ccgcgccggc
    19741 gaccggaggc caggaccaac gacctcgacc gccgcgcgag cgcgttatct gaccggcggg
    19801 ggcgaagccg aaggcgagcc ccccgccggg aagctcgcga agcgaggccg cgctcgccca
    19861 agcacggtca agggccgagc cccaggcgag gcccttgggc cgggattgca aaaataccgc
    19921 ccgcgccccc ggggcgacgg ggacgcgggc ggtgtcgaac gagtcgagac tagcccctgc
    19981 cggggctccc gcttaagagg ccaggaccgc ctgcaggaac tcgcgggtgc gctgctcggc
    20041 cggctcgccg aagatgcggt ccggcgggcc ctcctcgacg atctggccct ggtcgaacat
    20101 caggacccgg ttggagatgt ccttggcgaa gttcatctcg tgcgtgacgc acagcatcgt
    20161 caggtcgctc tcgcgggcga tgtcgcgcag caggtcctgc acgccgacga ccagttccgg
    20221 gtcgagcgcg gaggtgacct cgtcgagcag cagcaccttc ggctgcatgg cgagggcgcg
    20281 ggcgatcgcg acccgctgct gctgcccgcc ggacagctgc gaggggtgcg cgttctcctt
    20341 gtcggcgagc ccgaccatgt ccagcaggcc gcgggcgcgc tcgacggcct cgtccttgga
    20401 caccccgagc acgcgcaccg gcccctcggt gaggttgcgg agcacgttca tgttcgggaa
    20461 caggttgaac tgctggaaca ccatgccgac ctgcttgcgc atctcgtgca ggtgcctctg
    20521 gttcgcggcg acgcgccggc cgcccttgtc catgtgccag agcgtgtcgt cgccgatcca
    20581 gatcacgccg tcgtcgagct tctccagcgt catcagcagc cgcaggatcg tggtcttgcc
    20641 cgatccgctc ggcccgatca gcgtcacccg ctcgccgggc tcgacggcga agtcgagctc
    20701 gcgcagcacg gtgttggagc cgaaccgctt gacgaccttc tcgaagcgga tgccgggggc
    20761 gtcgccgtgc ggcagcgcgg ccgccgcgcc gtcgccgtcc tccttgcgga cgcccttctt
    20821 ctcggtcgag acggccggcg cggtcgcggc ggcgtcctcc gactcctcgg gggtgggggc
    20881 ttccggtgcg gtgtcagttg gtggcataac gcctctccag gcggcggacg agaatcgagg
    20941 aaatgacgct gacgacgatg aacagcaggc ccaccagcgt gatcggctcc aggaaccgca
    21001 ggctccgcga gcccacctgg tacgccgaca tgagcagctc cgtcacgttg atcgccagga
    21061 gcagcggcga gtccttgaac atcgcgatca ggtagttgcc cagcgtcggg atcacccgcc
    21121 ggatcgcctg cggcaggatc acgtccagcc acacccgcga ccgcggcagg ttcagcgcgg
    21181 tgcacgcctc ccactgcccg cgcgggatgt cggagatccc cgcccggtac acctcggcgg
    21241 tgtaggtcga atagtggatc cccagcgtga tgatcccggc ggtgagcgac ccgatcgtca
    21301 ggccccacga cggcagcacg tagtacacga agtacagctg cgggatcagc ggcgtcgacc
    21361 ggatgaactc ggtgacccac cgcacggtct ggctgacgac gacgttcggg gtgcggcgca
    21421 gcatcgccca caccaggccg aggagcaccg cgatgacata gccggcgagc gtcgcgatga
    21481 cggtgtagcg cagcccgtcc agcaggtcgg ggatgatgtc gccggtgtag ttccagtccc
    21541 agttcatcag ccggccaccc ccgctccggg cgcgcccgcc gcgaccgtcc cgaggtcggg
    21601 ttcacgggag gagcggcggc cgagcatccg gtcgacccgc cgttcggcgt agcggacgaa
    21661 cagctgcagc acctgcgcga tgacgaagta cagcaccagc gcgacggtga acgaccagac
    21721 ggtctgcccg gtgctgccct gcacgttctt ggacacgtgc gtgatgtcga cgaggccgac
    21781 gagcgagacg atggcggtgc ccttcatcag ctcgatgagc aggttgccga acggcggcag
    21841 catcagcgcg aacgcctgcg ggagcaggac gcgccgcatc cgctgcgcgg gcgtgaagtt
    21901 cagcgcgatc gtcgcctcgt actgcgcctt ggggacggcc ttgatcgagc cgcgcaccac
    21961 ctcggcgccg tacgcgccga cgttcatgcc gagcgcgagg accgccgcga acagggtggt
    22021 gaaccggagg ccgacgagcg gcagcgcgta gaagaaccag tagagcagca ccagggtcgc
    22081 ggtgccgcgg aagaactcca cgtacacccg gttcagggcg cggacccacc cgctgcgggc
    22141 ggtgcccgcg agcccgaaga gcagcgcgag gaccagcgcg agcacgccgc cgaagacggt
    22201 gagccggaag gtcagccacg cgccctccag ccactggtga tagctgtcga ggacctgcga
    22261 cacaggtcag ccctggcaga acttggcggc ggtgtcctcc gggcgcggca tctccgcctg
    22321 ggtgaacccg aacggctgca ggatcggcag cagctggttg ctcttctcca gcgccgcgag
    22381 ctgggtgttc caggcgttca gcaggtccga gtcggccttg cggaacacga acgcgccggc
    22441 gccgagctgc tccttgccct cgatgacggg cgtgaacgcg tccgtcacct cgtacttgcc
    22501 gtcctggtgc ttggacagca ggtcggccag cgagatgcgg gtcagccaga tgcagtcgat
    22561 gcgcccggac ttcaggccct cgtaggcgct ggcctggtcc tggaacgtct tgatgtcgct
    22621 cttcttgacg ccgctcttct cggcgtagcc ctgctcgacc gcgccggtca gcacgccgac
    22681 ccggacgccg gccttcgccg ggtcgttctg gttcttgagg ttcttcgggt tgcccttcgg
    22741 caccatgaag gcgctcttgg cgacgtactc ggggttggcg aacgcggcgg acgcgcaccg
    22801 ctccggcgtg atgaacatgc cggcggcgat cgcgtcgaag cgcttggcgt tgaggccgcc
    22861 gatcaggccg ccgaagtcga cctgcacgcc ctcgaccttg tcgatgccga gcttcttgaa
    22921 gacggcgcgg gccagctccg gcgcctcgcc ggtgagcttg ccgtccttgt cggtgtagcc
    22981 gtagggggcc tcgttggcga agccgacggt gatcttgccg gccttcttgg ccttgtcgag
    23041 ggtgccgccg ccggagacct ccttgtccgg atccgtcgtg gagcagcccg ccgcggccag
    23101 ggggacggcg gcggacagca gaacggcggt gcggaggaag tcgcgtctcg aggaagtcat
    23161 cgttgaactc ctgcagggag ggggtggccc gcgcccgcgg ggggccgtgg agaggccccc
    23221 cgcgggcgcg gggtccgtcg tcgggggtat ccagttggga gcggggagcc tggcgccggg
    23281 tcagtcgcgc acgggggtga agtcgcgggc cccgatgaac ggcgggcgcg gcgccggagc
    23341 cgagaacggc tcgacgcacg tgttctccac gctgttgaac acgacgaaca cgttggagcg
    23401 ggggaacggg gtgatgttcc cgttcgagcc gtgcatgcag ttgcagtcga acatggtcgc
    23461 cgagcccgcg ggcccggtga acagctcgat cccgtgcttg tcggcgagga tcgacaggct
    23521 gttcgggtcg ggggtgccga tctcctgccc gcgcagcgac tccttgtagt ggtcggccgg
    23581 ggtctccccg acacaggcca cgaaggtctt gtgcgatccg ggcatgatca ttagcccgcc
    23641 attgtgcacg aaattctccg tgagcgcgat ggaaatgctc accgcgcgca tcctcggcat
    23701 gccgtcctcg gcgtgccagg tctcgaagtc ggagtgccag tagaagtcct tgccggtgaa
    23761 gcccggcttg tagttgacgc ggctctggtg cacgtagacg tcggagccga gcagctggcg
    23821 ggcgcggccg accacgcgcg ggtcgcggac cagccggccg aacacctcgc tgatcttgtg
    23881 cacctcgaag atggagcgga cctcgtccga gccgcgctcg gtgaccgtgc gctcgtcggc
    23941 caggatctgc gggtcggagg ccagccggcg cagctcggcg cggtagtcct cgacctcctc
    24001 cggcgcgatc agctgctcga cggacaggaa gccgtcgcgt tcgaaggaat cgagggtggc
    24061 ggcgtcgatg gggccgtcgc cggggccgcc gtacacgacc gggtcctgcc ggtacagcag
    24121 cgccgcttcg gcggccttgc gggtggggta ggcgtcgtcg atcgacgggt gcgactcgat
    24181 gatgctcatg cgtcctcctc ggtgagcagc ggatagaccc cgttctcgtc atggacctcc
    24241 cggccggtgc agggcgggtt gaacacgcac acggtcttca cgtccgtgtg ggcgcgcagg
    24301 gtgtggtgct cgtgcccgtc gagcaggtac atcacgcccg gcctgatgtc gtgcttctcg
    24361 cccgtctcct cgttggtgag ctcgccctca cccgcgatgc agtagacggc ctcgatgtgg
    24421 ttcgcgtacc acatcctcgt ctcggtcccc gcgtacagga tcgtctcgtg cagcgagaac
    24481 cccacgccct ccttggccag cacgaggcgg cggctgcacc aggtcggtgc ctccacgtcg
    24541 cgctcggtgc cgatgatctc gtcaagggag cgaacgatca tgtcttcctc atttccggtg
    24601 tgttacgcgg cggcggcccg gcccggcggc cgggtcagac cgacaccttg gtgcggacgg
    24661 cgtcgaccga ctcggcgatg atctccaggc cgtgggccag ctcggtctcc gtcgtggtga
    24721 gcggcgggag cagcttgacg acctcgccct cggggccgga ggtctccatc agcagcccgc
    24781 gggagaacgc ctcggcgcac acctgcggcg cggtctccgg gtccttcatc accaggcccc
    24841 acgcgaggcc gcggccgcgg acggtgtcga tcgcgccggc gtgcgcgagg gcgatctcct
    24901 ccagcgccgt ctggacctgc tggcccttgg cgagggtctg cttctccatg ccctggccgg
    24961 tccagtagtc ctccagcgcg gcgacggcgg tgacgaacgc ggggttgaag ccgcggaagg
    25021 tgccgttgtg ctcgccgggc tcccacacgt ccagctcgcg cttcatcagc gtgatcgcga
    25081 acggcagccc gtagccgctg agggacttgg acaggcagac gatgtccggg gtgatcccgg
    25141 cctcctcgaa ggagaagaac gggccggtgc gcccgcagcc catctggacg tcgtcgacga
    25201 tgagcaggat gtcgtgccgg cggcacaggt cctggaggcc gcgcagccac tcggcggtgg
    25261 cgacgttgat gccgccctcg ccctgcacgg tctcgacgat caccgcggcg ggcttgtcca
    25321 ggccgctgcc gctgtcgtcg agcatcgtgt cgaacagcag gaagtcgggc gtgcggccgt
    25381 cgaggtagtt gtcgtacggc atcgcgacgc cgtgcccgag cggcacgccg gcgccggtcc
    25441 gcttcatcga gttgccggtg acggcgagcg cgccgagcgt catgccgtgg aaggcgttgg
    25501 tgaagctgac gacggtctcc cggccggtgt acttgcgggc cagtttcagc gccgcctcga
    25561 ccgagttgtt gcccgccggg ccggggaact ggaccttgta gtcgagcccg cgcggctcga
    25621 gcacgtactc gttgaatcgt tccaggaact cgcgcttggc ggtggtgtac atgtcgaggc
    25681 tgtggacaat ggcgtcgctc gcgagatagt ccatcagccg gcgtttcagc tgcgggttgt
    25741 tgtgcccgta gttcagcgtg cccgcgccgg cgaagaaatc gaggtaggtc cggccgttct
    25801 catcggtgat gtgggagccc tgggcggtgc ggaacaccgc cggccaactc ctgcagtagc
    25861 cgcggacttc cgattccata cgagcgaaaa cgtccatgtt ctgcctccgg caggtcgggg
    25921 gtgggagcgg ttcgggcgaa tgcggtgccg gccggcaccg gtcggatgcg tgcggtggtg
    25981 cggactcgag cggactcgga gcggactcgg agcggaagcg ggccggcggg ggacccgccg
    26041 gccgcgggtc aggtggcggc gccgagcggg ccgatccgga acagcacctc gggctcgtgc
    26101 ccgccgcccg ggaaatgctc ggcttcgaag agcggctcgc gggtcagcgc gcagccgcgg
    26161 tcccgggcga atgaggcgaa catcgcctcc gaggccttgt tgtcaggggt cacggtcgct
    26221 tccatgtacc ggtgcccgcg ggccgtcagc cggtcgccga ggcggtccag catgcggcga
    26281 gccaaaccct gcccgcgatg cgcctggtca accgccactt gccacacgaa gaaggtgtcg
    26341 gggcgggacg ggcggacgta gccggtgacg aaaccgcagg cgcggccgcc gtcgcgggcc
    26401 accaccgagg tgtcggcgaa gtcgcggcac cagagcgcgt agctgtacgg cgaattgacg
    26461 tccaggacct tggagtcccg ggcgatccgc cacagttcgg ggccgtcggt gaggctcggc
    26521 tcctggagtt gcacgtccac ggtcgtctcg tccggatcgg ggcgtcgggt ctgtgattcc
    26581 aggtgttgcg gtgccatgtc caggcaactt agcgaatctc gccgtgtgat cgttccgtaa
    26641 tgttatcgtc aggatgttta gcctggcgag caacgggtat ggcagcacgc ttgccaaatt
    26701 ccggatgttt tcggccgacc gttctcgtgg ccgcagtgcg ccatttccag cgatacgcag
    26761 gaggtactgg cgccttcgcg ggcgcccgcg cggcgcgcct tcctgaacgc caccttaatg
    26821 ttcggcgccc gagagcagag cgtttttgtg tatcggttgt gtgaggtaag tcactaggat
    26881 tgggtgacaa cgggaagcct gcggtcggcg tcacgtcgca tcgcgggagg tcgtgcccgc
    26941 gcccgtggcc gtggggcgga tgggggctca ggcgtgcgag gcgggccctg tgagccccct
    27001 cacctcacct tcaaggggga gaccacctcg ccgccgggta aacgagggtt agcggccgcg
    27061 taaggattga acccgtccgg cgggcatcgc ggacgccgcc gggaccccgc gcggacgcgg
    27121 aatcccggcc tcgttccggt cgtacggagg acgcggttga ggtgcgtccg atatcgcgga
    27181 tcggccggcc gccgcgcgaa gggccccagc cggtccgcgc gaatcgctca gccggtccgt
    27241 ccgagacgct cagccggtcc gtccgagacg ctcagccggc gaaacggtcg gtcgcctcga
    27301 cgaggcggtg caggatcccc ggctcgctgt aggcgtggcc cgcgtcgtcc acgatgtgga
    27361 aatcagcctc cggccacgcg cggtgcaggt cccacgccgt cgccgccggc gtgcacacgt
    27421 cgtagcggcc ctgcacgatc accgccggga tgtgccggat cttgtccacg tcccggatca
    27481 gctgctcgtc ctcgaagaac ccctcgttca cgaagtagtg gttctcgatc cgcgcgaacg
    27541 ccaccgcgta gtccggctcg ccgaacccct ccgccagctc cgggtccggg cgcagcgtca
    27601 gcgtcgagcc ctcccatgtc gcccacgcct tcgccgccgc gacccgcacg tcccggtcgg
    27661 gggagttgag ccgctcgttg aaggcggaca tcaggtcctc ccgctcgtcc tccgggatcg
    27721 gctcgacgta cttctcccac aggtcgggga agatgagcga cgcgccctcc tggtagaacc
    27781 agtacagctc gaacgggcgc agggtgaaga tgccgcgcag caccatctcg gtgacccgct
    27841 ccggatgcgt ctgcgcgtac gccagcgcca gcgcgctgcc ccagctcccg ccgaacacca
    27901 gccaccgctc gatgccgagg tgctcgcgca gccgctccat gtcggcgacc aggtgccagg
    27961 tggtgttgct ctccagcgag acgtccgggt ccttggcgtg cggcaggctc cggccgcagt
    28021 tgcgctggtc gaacagcacg atccggtagc gctccgggtc gaactgccgg cggtgcgccg
    28081 cgctgcaccc gccgcccggg ccgccgtgca gcatcaccgc cggcttgccg tcggggttcc
    28141 cgcagacctc ccagaagatc tggttgccgt cgccgacgtc gagcaggccg gagtcgtagg
    28201 gctcgatcgg cggatacagg gtgcgaagct ccatggtgcg gaatcatcgc atccggcgac
    28261 cggctccgcg ctttcccgcg cggcgcggtg tgacccgtgg caccgttggg ggtgcgggag
    28321 ggggcccgca ccgggtgtga ccaggcgtcc ggcccccgcc cgcaccgaga ggcgagcacg
    28381 aaactaaacc ccaaactggg caaacgttcc gctggtcggc actagagtgc cttcagtgag
    28441 cggagcgacg agccctcggg cgaggagtga cgcgagcgcc atgtccatga cagcccccgc
    28501 ggaacacggc ccccggacgg agccgtcggc gaggagacgt gagagcgaag tgacgagccg
    28561 cgaggcgagg aactgcagcg acccgagcgg gcgtcccggc gctccgctcg agcgtctccg
    28621 ggcctcgagg cgaggagacc agtgagtgag ctgaacggat cgggtggttc gcgcggagtc
    28681 ccggacgcgg gttctccctg gcccgcgatg gggcgggacc cgggccgcgg gtccgacgtg
    28741 cccgtgcctg ccgcccagca gccgatccag atggccaagc ccgaccagcc cgccctgccg
    28801 ggccgggtcg ccgacgccgg acgcccggag ggcgagcagc ccgaggccca gccgtgggac
    28861 atcgtcgagc ggctccgcca gatggccgac ctcatcggcg acgcgctcgc cgccggcgag
    28921 cggaaggtca ccgaggcgca gagcgagacc gcttcgcagg tcgcggcgat ccaggcggag
    28981 aaggagtcgg cgcagcgcga cgccgcggcc gcgtggggcg aggtgcagcg cgcgcggggt
    29041 caggccgagc aggccgaccg ccgcgccgtg gacgccgagc gccgcatcac cgaggcgcag
    29101 aacgaggccg cttcgcaggt cgcggcgatc caggcggaga aggagtcggc gcagcgcgac
    29161 gccgcggccg cgtggggcga ggtgcagcgc gcccggggtc aggccgagca ggccgaccgc
    29221 cgcgccgtcg aggccgagcg caaggtcgcc gaggccgagc gccgcgccgg cgaggtgcag
    29281 aacgaggccg tcacccagat cgccgccctc cagcaggaga aggaggccgc gcagcgcgac
    29341 gccgcggccg cctggaacca ggcgcagcag ggccgcgccc aggccgacca ggcccgcggc
    29401 caggccgagc aggcccgcgt gcaggccgac caggcgcgcg cgcaggccga gcaggcccgc
    29461 gcccagatgg agcaggcgca ggctcaggcc gagcaggccg agcgccgcgt cgccgaggcc
    29521 gaggccaccg tccggcaggc catccagcag cgcgacgcga tgagcgaggc ccgcgacgac
    29581 g
//
