LOCUS       NZ_CP053892            22538 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9145003
            Orig. end                         :: 9167541
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..22538
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="27"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22538
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22538
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12538](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12538
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            26..781
                     /locus_tag="ACTIVE_RS41200"
                     /old_locus_tag="ACTIVE_8268"
     CDS             26..781
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835312.1"
                     /locus_tag="ACTIVE_RS41200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8268"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_173100024.1"
                     /sec_met_domain="PhyH (E-value: 1.6e-05, bitscore: 24.4,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHEIDVDAFVADGFVRVPEAFPRELAAECRAILWRDTGCDPDDRS
                     TWTKPVIRLGGYGTPPFRAAANTPRLHAAYDAVAGEGAWQEPGGLGTFPIRFPSTEAPG
                     DDGWHIDASFPGDDPNDFMGYRVNLASKGRTLLMLFLFSDVGEDDAPTRIRVGSHLDVP
                     PILEPAGDEGVAFMDIPGKAVPASEHRPVALATGRAGDVYLCHPFLVHAAQPHHGTEVK
                     FMAQPPLLPSGPLPETSPVRTAIQRGLGR"
     gene            832..3861
                     /locus_tag="ACTIVE_RS41205"
                     /old_locus_tag="ACTIVE_8269"
     CDS             832..3861
                     /EC_number="6.1.1.14"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890928.1"
                     /locus_tag="ACTIVE_RS41205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8269"
                     /product="glycine--tRNA ligase"
                     /protein_id="WP_173101777.1"
                     /transl_table=11
                     /translation="MQDALIRLTGYWAGHGCLVGQPMNTEVGAGTLNPNTALRVLGPEP
                     WRVAYAEPSVRPDDSRYGDNPNRLQTHTQFQVILKPEPGNAQELYLGSLAALGIDLRAH
                     DVRFVEDDWASPALGAWGLGWEVWLDGLEITQFTYFQQSGGIALDPVSVEITYGVERIM
                     MALQGVSHFKDIAYAPSIGTARGGTTPHAPRADSVGISYGEAFGQAEYEMSRYYLDDAD
                     IAANRELFETYASEARRMLDARLPVPAHSCVLKCSHAFNVLDARGAIGTAERARAFARM
                     RGLAHEVAALWVERRAELGHPLGDATVFEIALEKTVLREIAAPAAFALEIGVEELPSAE
                     VRPAAEAVAERLRTGLEAAGLLTDASAVDAFSTPRRLIAVVRDVEPKSPDTEEVVKGPR
                     LAAAYDASGEPTRALLGFARGQGIDAADVRAITVGGKEYAAHVRTVAGKPAAQVLYGLV
                     HEIVSGLRAGKNMRWNLPGLSFARPVRRVLALLGHRQIVVDELNRGRTTDVHRAADPSR
                     VPVPDALSLIGVLREHGIEPDPARRRTRIVEDARTLAAGHGGTVDAAAEEDLVEEIVDL
                     VEEPVAILGSFDAKYLDLPEAILTTVMRKHQRYLPVRGPSGELLPHFVTVANGECDHDV
                     VRAGNEAVIRARYEDAAFFFQQDLRSRPEEIKHGLDRLTFTERLGSMADRSSRIAAIAA
                     DLADRLDLPPGERAVLDRAAALAKFDLASAMVIELPGLAGTMAREYARRAGEDAAVAQA
                     LSEMELPRSAGDAVPATAAGAVLAAADRLDLLAGLFAVGAAPAGGSDPFGLRRAALGLL
                     AILRAVPSPAAAPLTVGGGLAIAARHQPVEVPPEALAEAERFTARRLEQSLLDEGLPIP
                     AVRAVRPLAGDPARAARAASDLAGLLRTDEFARLTTALQRVLRIVPEGTEAGYDRGLFA
                     EPAEGRLAEALSRFRDALPPRPSLPESVSAAAGLPAPIDAYFDDVMVMDKDPVLRANRL
                     GLLAAIRDLVAPVLDWREVG"
     misc_feature    complement(844..857)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.45"
                     /tool="antismash"
     gene            complement(3858..4880)
                     /locus_tag="ACTIVE_RS41210"
                     /old_locus_tag="ACTIVE_8270"
     CDS             complement(3858..4880)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021599.4"
                     /locus_tag="ACTIVE_RS41210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8270"
                     /product="DUF2332 domain-containing protein"
                     /protein_id="WP_173100025.1"
                     /transl_table=11
                     /translation="MRGVREELLDQARVCAAQGSPMYAELLARAADDADAGGPVADVLA
                     DRASSALALRMLGTVHRIVLEGRAPALAAHYPTAGGTADPLAAWPAFRDVLARRTAEVR
                     AGLADAPQTNEVGRAAPLVGGLLAVAAATGLPVRLLEIGASAGLNLRADHYRLLFPGGG
                     YGPDSPVVLPDAWRGTPPKAVPLRIAARLGCDLAPLDAAAPEGRRRLLSYVWPDQHARV
                     ARLRAALEVAARVPAAVVRAGAGDFLDGLAPEPGAVTVVWHSVMMQYLPDEEAARVHRH
                     VEAAGAAASSGAPVAHLAFEPPGTAHITGTPLLTLRLWPGGERRVLGEAPPHGLPFTWY
                     "
     misc_feature    complement(4968..4981)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.13"
                     /tool="antismash"
     misc_feature    4989..5002
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.08"
                     /tool="antismash"
     gene            5004..6629
                     /locus_tag="ACTIVE_RS41215"
                     /old_locus_tag="ACTIVE_8271"
     CDS             5004..6629
                     /NRPS_PKS="Domain: AMP-binding (26-436). E-value: 3.3e-80.
                     Score: 261.6. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS41215_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="ACTIVE_RS41215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8271"
                     /product="AMP-binding protein"
                     /protein_id="WP_173100026.1"
                     /sec_met_domain="AMP-binding (E-value: 5.2e-85, bitscore:
                     284.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNLHDGRDYRAHGWWRDGTFLDDLAARAAAAPDRPAVVSHFWET
                     AGGPDTVLTWAQLHERVERCAAGLAALGVRPGDRVAMQLVNQWQATVLALGCGRAGAAV
                     VPYYIASGPADTEWILRESGASAVVSLDEVRGLDIAATIAGMRDRLPALRHQIVVGEKV
                     PEGAVGFEDGLLASDAAPPAHRPGGDDVFQIMYTSGTTGRPKGVRHSFNTLYAMARSFT
                     VPLGLGPDDVLSTPCIVGGQGGWLYGMLAPLVAGAAAVWADAFKPGDFLDLAAEYGITT
                     AYFTPLILDELVAEQRENPRPLALRHMVTGSTPIPPGLPARFRETFGFPVRPLWGMTEN
                     GGVTIGRAEDPPDWAARSDGRPVDWMEVRLVGEDGAPVDGPGRLEVRGANLCLGYEGAD
                     DVFAASLHDGWFVTGDLARPDGRGGIKIIGRTKDLINKGGLHVPAVAVEEVLRAHPNVA
                     EIAVVGEPEPLLGETVVAVVVPAGDPPALEDLHRLVREAGMTPGYEPDRLEVVAELPKT
                     PTGKVRKRAIEEDLARRASAAAAP"
     aSDomain        5082..6311
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS41215_AMP-binding.1"
                     /evalue="3.30E-80"
                     /label="ACTIVE_RS41215_AMP-binding.1"
                     /locus_tag="ACTIVE_RS41215"
                     /protein_end="436"
                     /protein_start="26"
                     /score="261.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ARAAAAPDRPAVVSHFWETAGGPDTVLTWAQLHERVERCAAGLAA
                     LGVRPGDRVAMQLVNQWQATVLALGCGRAGAAVVPYYIASGPADTEWILRESGASAVVS
                     LDEVRGLDIAATIAGMRDRLPALRHQIVVGEKVPEGAVGFEDGLLASDAAPPAHRPGGD
                     DVFQIMYTSGTTGRPKGVRHSFNTLYAMARSFTVPLGLGPDDVLSTPCIVGGQGGWLYG
                     MLAPLVAGAAAVWADAFKPGDFLDLAAEYGITTAYFTPLILDELVAEQRENPRPLALRH
                     MVTGSTPIPPGLPARFRETFGFPVRPLWGMTENGGVTIGRAEDPPDWAARSDGRPVDWM
                     EVRLVGEDGAPVDGPGRLEVRGANLCLGYEGADDVFAASLHDGWFVTGDLARPDGRGGI
                     KIIGRTKDLIN"
     CDS_motif       5583..5627
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS41215_0001"
                     /evalue="2.00E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="ACTIVE_RS41215"
                     /protein_end="208"
                     /protein_start="193"
                     /score="20.4"
                     /tool="antismash"
                     /translation="IMYTSGTTGRPKGVR"
     gene            6626..8041
                     /locus_tag="ACTIVE_RS41220"
                     /old_locus_tag="ACTIVE_8272"
     CDS             6626..8041
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="ACTIVE_RS41220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8272"
                     /product="MFS transporter"
                     /protein_id="WP_173100027.1"
                     /transl_table=11
                     /translation="MIPARRRALALTSVILANVMAVIDYNVVSVAIPRLLRAYPGSTLT
                     GLSWTITGYTVVFAAVLLPAGGMADRLGPKRIFLAGLAVFTAGSAACALAPGPLGLVLA
                     RLLQAAGGGAVVALAISVGLSEFPGRAGHAFGLLGAVSGIAGASGPALGSALMALGGWR
                     WIFLINLPLGALALACGAAGIPAGTRTGRGLPDLAGVALLAGGVAALVLGLVQGPVWGW
                     THPGVLGAAAGGTALTWLGVRRSLRHPRPAADFALLRAASTAAGNAAMALMSVTQFAVA
                     LCVALFLTERWGYSALTAALALTPGPLTSAAVSWCAGPLVRRAGARAVAVAGGLTGALG
                     WCWPLAAGAAGAGRDYAVAVLPALVVGTAGMAATAVAVETIAMRAVPPARYGSGSALIM
                     LARSAGAAAGIGGLAAVLHEPSARGFDAAWAGLAAGMLAAALAGAAGQRGARDPDSGRG
                     RRRAVSAEGGARP"
     gene            complement(8411..9274)
                     /locus_tag="ACTIVE_RS41225"
                     /old_locus_tag="ACTIVE_8273"
     CDS             complement(8411..9274)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF041188.1"
                     /locus_tag="ACTIVE_RS41225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8273"
                     /product="family 3 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_216858132.1"
                     /transl_table=11
                     /translation="MLDYLIDDPALRERGPGEELAVAVARAAGGDAAVRVRRPLTALFP
                     LASTRPRPTVREQTKGGTVTGGPLRYVRELPGEGGGASGTAYRATPEAVFRASAAKAEL
                     TEISVAVAVPAELRRDPALLARFVEHRVIVRLCTVENEVLLHGSGDGAITGLLNLEGLR
                     RLPAPDVLDAPAGTALDALMAACAEVEETGGSCDGLVMHPALYWRLVGAGALPALDSAG
                     LRITRTRMIARDRVLLGDFRAGVTLLDGEESVLALRGDGDAVTITASMPLGLAVHLPQH
                     FVLLSL"
     misc_feature    complement(9414..9430)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 14.8"
                     /tool="antismash"
     gene            9491..9718
                     /locus_tag="ACTIVE_RS41230"
     CDS             9491..9718
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS41230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_173100029.1"
                     /transl_table=11
                     /translation="MRHPEKQGGRAAAFADPIIDERTGTGTRPAARPAPGCPLRAAALA
                     AEAAEAHSTEAADGPARQGRPPAGAPGDGR"
     gene            10001..12538
                     /locus_tag="ACTIVE_RS41235"
                     /old_locus_tag="ACTIVE_8274"
     CDS             10001..12538
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="ACTIVE_RS41235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8274"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_173100030.1"
                     /sec_met_domain="DUF4135 (E-value: 3.8e-73, bitscore:
                     245.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 7.8e-15, bitscore:
                     53.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQPALAEELAAASARGLDGGTPQDRYAAFVRGLADPARALRIW
                     AAYPVLARQVVEILDDWVAARLAFARELAADLPAVTAAFGGREGLGALTGVEFGQAETH
                     RGGRTVAIVRFERAVLVHKPRPLAVDLCFDRLLGWFNDAGVPHPLRRPRLLDRGDRGWS
                     EYIEPAPCAPGDLPAFFWRMGALLALTHAVHGYDLHADNVIAAGADPVVIDLEALFHTS
                     GTQPGVRRARLGDPAAERLEASVLRTGLLPGPLVMPDVGTERPFGVDISPLGTVPDRRS
                     LIPTPLVDDPGTDRMRVRLGYRTVPPPAGRLRLPGGGTVDPRPHRDALVAGYTAAYRRL
                     ASAGTGLLAPGGPLHGCADVPVRLIQLSTFLYVRLLLESWRPDALRDAAQGERGLARLD
                     AGWPGVPHRDALVAAEKAAVWRGEVPVFEVRPGHRDVWLEDGTRLPDVLPVPPLEETAA
                     RLAALDEDDLAVQTGIIDASLAALPPAPGPSPVRAPRPSGDPLRDALGIARRLDAAAVR
                     SGDRIGWLGIEVVDARARRVAPAGLGLYGGLPGIGLFLGHLSAVTGESWVAGLAERVAD
                     EVAARLAAASGVPGTVPPLGPVYHLAHAAAVHGRRDLAEAARDALLPAPPGPPSGDVLE
                     GEAGALLSALALHAVLPGEQVAGIARAAGERLLARDLTGPGFGYGASGAAVALARLDAL
                     CPDPRFASRALSLAAAERAPGTDPGWCQGAAGVALARLELAARYPSAAARLEQPLEAAA
                     AVLRNAAAPDDSLCHGTSAVHEALAALDEPLPRQPHGALRTALPEPAPGLLAGLSGIGY
                     ALLRRARPAEVPSVLALAPPAPSSLLFPPEETP"
     gene            12535..13788
                     /locus_tag="ACTIVE_RS41240"
                     /old_locus_tag="ACTIVE_8275"
     CDS             12535..13788
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013227.4"
                     /locus_tag="ACTIVE_RS41240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8275"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_173100031.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1e-66, bitscore:
                     224.7, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-07, bitscore:
                     30.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVDVQPGPLAIDGAEPVRTDPWPTYDKGDVFIEEEDLEAALDAV
                     RARLYFRYDHRPHAETRTGRLERELCAFFAAPHALACASGTAAITLALLALDLPPGSLI
                     ACPAFTFAATPSAILLAGHRPLLVECDDDLHLDVADLRRRLTPEVRAIVVVHMRGFASD
                     MDAICAVAREHGVPVVEDAVPALGARLNGRPLGTFGDAGAFSTQSDKSLNTGEGGFLLA
                     RDPAVHARAVVYSGAYEGRMARHFDGAPPPVDDLAYPIFGLRMDEIRAALASALLRRLP
                     ERLAAHHRNYGDVAGRLADVPGIALRRPVADHAYLGEALVFRLPGAGADATAWTAAALR
                     AEGIDARALGDPGDTNVRAFWNWRFLFPDPARARAEFPVTAARLDESVDVPLSANLTER
                     DRDHLVTAVRKVVGAGRC"
     gene            13788..14750
                     /locus_tag="ACTIVE_RS41245"
                     /old_locus_tag="ACTIVE_8276"
     CDS             13788..14750
                     /EC_number="2.8.2.-"
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050656 - 3'-phosphoadenosine
                     5'-phosphosulfate binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_3: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018656684.1"
                     /locus_tag="ACTIVE_RS41245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8276"
                     /product="sulfotransferase"
                     /protein_id="WP_173100032.1"
                     /transl_table=11
                     /translation="MVRVLYVTGWCRSGTTLLGNLLGECGGVVHVGELRYLWTNGILGR
                     GTNALCGCGLDVASCPLWKGVVARVAGDDPGWHAERAVRLQQAALRTRHTGRRLAEARG
                     ARAGHPAVSALAALYAAIAEESGARLIVDTGKFPAEAAALCGAPGVDARVLHVVRDPRA
                     TAESWRRAKEYIPAMGAARSTAYWTGFNLASERIARAFPRRCLRLRYEDFTADPRGSLA
                     RVMAHAGLDGDPPVGADGRADLGVNHTVTGNPDRLRRGAVRIREDDAWTRTQPAPARLV
                     ATALALPLLARYRYPLVPAAAHQGRRAPDTRSPRREGAA"
     gene            14750..15499
                     /locus_tag="ACTIVE_RS41250"
                     /old_locus_tag="ACTIVE_8277"
     CDS             14750..15499
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853707.1"
                     /locus_tag="ACTIVE_RS41250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8277"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_173100033.1"
                     /transl_table=11
                     /translation="MDLGLTGRVAMVAAATSGLGLAAARELAAAGADVAICGRDPDRLD
                     RAAAEIDKAGPGRTVPTRLDVLDHDAAAAWADRTAIDLGGPHVLVTNAGGPPGGPVLGR
                     SLDDFRAAVELSVLSHVALVQAALPHMRDAGWGRVLMIASETMRQPTPRYGLSSTVRPA
                     LAGFARTLVRELGPAGITVNVLAPGYHRTPAVASMPDLDEVAASIPLGRLGRPSDFGAV
                     AAFLAGEQAGFITGTTLVVDGGLGRGI"
     gene            15515..16144
                     /locus_tag="ACTIVE_RS41255"
                     /old_locus_tag="ACTIVE_8278"
     CDS             15515..16144
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="ACTIVE_RS41255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8278"
                     /product="nitroreductase family protein"
                     /protein_id="WP_173100034.1"
                     /sec_met_domain="PF00881 (E-value: 4.3e-21, bitscore: 74.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFDDVLAARRMVRRYRPDPVPADAVERIAAMVRKAPSGGFSQGH
                     RLIVVTDPVTRARIAELAQEPYYTRDGEPPWLSVAPVLMVLGICEDDYHARYTKPDKLV
                     DGQEMEWPAPYWWVDSGALLMLIQLAAINEGLASGFATVPAKDELAALLGVPPEIAIVG
                     VITIGYARADAVRPADTARLRSMRKPFGDLVRHESWKDGARPAGTP"
     gene            16238..17416
                     /gene="aroC"
                     /locus_tag="ACTIVE_RS41260"
                     /old_locus_tag="ACTIVE_8279"
     CDS             16238..17416
                     /EC_number="4.2.3.5"
                     /GO_function="GO:0004107 - chorismate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="aroC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291537.1"
                     /locus_tag="ACTIVE_RS41260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8279"
                     /product="chorismate synthase"
                     /protein_id="WP_173100035.1"
                     /transl_table=11
                     /translation="MLRWLTAGESHGPALTAIVEGLPAGVRVTSADIAEDLRRRRLGHG
                     RGARMKFEQDQVTILGGVRHGTTLGGPVAIQVGNTEWPKWETVMSADPVDPDVLAAQAR
                     NAPLSQPRPGHADLVGIQKYGFDDARPVLERASARETAARVALGTVAKAFLKQALGVDV
                     LSHVIALGEVEAPDGVLPGPDDLAAVDESPVRCFDGAASAAMVAHIDEMKKAGDTLGGV
                     VEVLAYGLPPGLGSHVHWDRRLDARLAGILMGIQAIKGVELGDGFTTARRPGSRAHDEI
                     DNTPDGIRRRTNRAGGVEGGMTTGEVLRVRAAMKPISTVPRRLDTIDVKTGEPAKAINQ
                     RSDVTAVPAAGVVAEAMVALVLADAALEKFGGDSAEETARNLRGYLSSLTIK"
     gene            17433..17942
                     /locus_tag="ACTIVE_RS41265"
                     /old_locus_tag="ACTIVE_8280"
     CDS             17433..17942
                     /EC_number="2.7.1.71"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004765 - shikimate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291538.1"
                     /locus_tag="ACTIVE_RS41265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8280"
                     /product="shikimate kinase"
                     /protein_id="WP_173100036.1"
                     /transl_table=11
                     /translation="MTRPKAVLIGPPGSGKTTVGTALAERLGVPLRDTDADTEAAAGKP
                     IGEIFIDDGEERFRELERAAVAAALAEHEGVVALGGGAVLAAETQELLAGHTVVYLKVG
                     LSEAIKRVGLASARPLLVLNPRSQMRKLLEERLPIYERLGTLHVDTDGREPADVAEEIV
                     KALEAA"
     gene            17939..19012
                     /gene="aroB"
                     /locus_tag="ACTIVE_RS41270"
                     /old_locus_tag="ACTIVE_8281"
     CDS             17939..19012
                     /EC_number="4.2.3.4"
                     /GO_function="GO:0003856 - 3-dehydroquinate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630742.1"
                     /locus_tag="ACTIVE_RS41270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8281"
                     /product="3-dehydroquinate synthase"
                     /protein_id="WP_173100037.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.7e-06, bitscore: 26.2,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 3.3e-89, bitscore:
                     297.6, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSARVHVGGADPYDVVIGTGVLAELPAMVGDRARTVAVVHAEGL
                     PEIARPVCGALEEAGYAVLALPVPDGEAAKEAGVLAGLWSAFARAGMTRTDAVVGVGGG
                     ATTDLAGFAAASWLRGVRSVLVPTTLLGMVDAAVGGKTGINVPEGKNLVGAFHPPAGVL
                     CDLATLVTMPREDYISGLAEIIKAGFIADPKILDLVEDDPEGAASPAGPHTRELVERAI
                     QVKADVVSADLKESGLREILNYGHTLAHAIEKAEDYKFRHGHAVAIGMVYAAELARLAG
                     RLPADVVRRHRDVLSSVGLPVSYAADWPGLRATMTIDKKSRGATLRFVVLDGIAEPGRL
                     EGPDEDLLAAAYQEVSR"
     gene            19009..19452
                     /gene="aroQ"
                     /locus_tag="ACTIVE_RS41275"
                     /old_locus_tag="ACTIVE_8282"
     CDS             19009..19452
                     /EC_number="4.2.1.10"
                     /GO_function="GO:0003855 - 3-dehydroquinate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853276.1"
                     /locus_tag="ACTIVE_RS41275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8282"
                     /product="type II 3-dehydroquinate dehydratase"
                     /protein_id="WP_173100038.1"
                     /transl_table=11
                     /translation="MSRVLVLNGPNLGRLGSREPEVYGSTTLDDLAALCRDTGHRLGLT
                     VEVRQTDDEAELIRWVHEAADERLPVVLNPAAFTHYSYGLRDALAQRTAPLVEVHISNP
                     ATREEFRHTSVVAGVATGTIAGFGMMSYVLALQAVAELLAESP"
     gene            complement(19693..20268)
                     /locus_tag="ACTIVE_RS41280"
                     /old_locus_tag="ACTIVE_8283"
     CDS             complement(19693..20268)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853274.1"
                     /locus_tag="ACTIVE_RS41280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8283"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_173100039.1"
                     /transl_table=11
                     /translation="MGTDSRERMVRSAAYLFRERGYSGTGFRDVIAHSGAPRGSIYHHF
                     PDGKAQLAEEAVRYAGEFLNAGILAATEGGDAASAVDAFVGWWRQVLIKSEFRAGCPIV
                     AVTVESHDDAPQLASAAAAAFDRWQDTLATGLGNAGVPDDRAARLARLIVAAVEGATIL
                     CRAHRDVAPLDDVVAELKEMTRNAVQED"
     misc_feature    complement(20273..20287)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.29"
                     /tool="antismash"
     misc_feature    complement(20274..20289)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.39"
                     /tool="antismash"
     misc_feature    complement(20276..20289)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.01"
                     /tool="antismash"
     misc_feature    20277..20292
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.14"
                     /tool="antismash"
     misc_feature    complement(20279..20292)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.23"
                     /tool="antismash"
     misc_feature    20279..20293
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.01"
                     /tool="antismash"
     misc_feature    20280..20293
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.36"
                     /tool="antismash"
     misc_feature    complement(20296..20310)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.24"
                     /tool="antismash"
     gene            20377..20832
                     /locus_tag="ACTIVE_RS41285"
                     /old_locus_tag="ACTIVE_8284"
     CDS             20377..20832
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144: thioesterase superfamily protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657279.1"
                     /locus_tag="ACTIVE_RS41285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8284"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_173100040.1"
                     /transl_table=11
                     /translation="MAGTATTAGLEQLKALINKGAEEGYGIGALLGMAAEALEPGRVVF
                     SLAPRTDFSNPLGTVHGGVLSTLLDSAMGCAVHTSLPEGAGYTTLELKVNFVRAVPLEG
                     GRLTCEGTTVHVGRKVATAEGRIVNADGKLVAHGTTTCMIFPPATDQ"
     gene            20867..21532
                     /locus_tag="ACTIVE_RS41290"
                     /old_locus_tag="ACTIVE_8285"
     CDS             20867..21532
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (5-195). E-value: 2.4e-33. Score:
                     107.4. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS41290_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657278.1"
                     /locus_tag="ACTIVE_RS41290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8285"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_173100041.1"
                     /transl_table=11
                     /translation="MIDLRRDGDVHVLRFDDGENRFSPDFLSAVEGALDTVEKSEGPGA
                     LVTTGTGKFYSNGLDLDWLGAHRDEFEPYLGRIHALYARLLELPMPTVAALNGHAFAGG
                     GMLALAHDFAVMRTDRGYFCLPEVDLGMTFTPGMNALIGARLPKRTAHEAMVTGRRYTA
                     DQAMAAGIVQRTADEAGVLPAALELAGSLAGKDGRVVGRIRADLFRPALEALRGPALG"
     aSDomain        20882..21451
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS41290_ECH.1"
                     /evalue="2.40E-33"
                     /label="ACTIVE_RS41290_ECH.1"
                     /locus_tag="ACTIVE_RS41290"
                     /protein_end="195"
                     /protein_start="5"
                     /score="107.4"
                     /tool="antismash"
                     /translation="RDGDVHVLRFDDGENRFSPDFLSAVEGALDTVEKSEGPGALVTTG
                     TGKFYSNGLDLDWLGAHRDEFEPYLGRIHALYARLLELPMPTVAALNGHAFAGGGMLAL
                     AHDFAVMRTDRGYFCLPEVDLGMTFTPGMNALIGARLPKRTAHEAMVTGRRYTADQAMA
                     AGIVQRTADEAGVLPAALELAGSLAGK"
     misc_feature    22292..22306
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    complement(22447..22461)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
ORIGIN
        1 cgggcgccgt cggcatcctg gcccgatgca cgagatcgac gtcgacgcct tcgtcgcgga
       61 cgggttcgtc cgggtcccgg aggcgttccc ccgggagctg gcggccgaat gccgcgccat
      121 cctctggcgc gacaccggct gcgaccccga tgaccgctcc acctggacca agccggtgat
      181 ccggctcggc gggtacggca cgccgccgtt cagggccgcc gcgaacaccc cgcggctgca
      241 cgccgcctac gacgcggtcg cgggcgaggg cgcgtggcag gagccgggcg gcctcggaac
      301 gttcccgatc cggttcccga gcaccgaggc gcccggcgac gacggctggc acatcgacgc
      361 gagcttcccc ggcgacgacc cgaacgactt catgggctac cgcgtcaacc tggcctcgaa
      421 gggccggacg cttctgatgc tgttcctgtt ctccgacgtg ggcgaggacg acgcccccac
      481 ccgcatccgc gtcggctccc acctggacgt cccgccgatc ctggaaccgg cgggcgacga
      541 gggcgtcgcg ttcatggata tccccgggaa ggccgtcccc gcgtcggagc accgtcccgt
      601 cgcgctcgcg accggacggg ccggcgacgt gtacctgtgc cacccgttcc tcgtccacgc
      661 cgcgcagccg caccacggca ccgaggtcaa gttcatggcg cagccgccgc tgctgccgtc
      721 ggggccgctc cccgagacgt ccccggtgcg gacggcgatc cagcgaggtc tcgggcgcta
      781 acgcatctac gcttagccgc tcgacccgtt gggagaacca ccgtgctgac catgcaggac
      841 gccctgatcc ggctcaccgg gtactgggcg gggcacggct gcctcgtcgg gcagccgatg
      901 aacaccgagg tcggggcggg cacgctcaac ccgaacaccg ccctgcgcgt cctcgggccc
      961 gagccgtggc gcgtcgccta cgccgagccg agcgtccgcc cggacgactc ccgctatggc
     1021 gacaacccga accggctgca gacccacacc cagttccagg tgatcctcaa accggagccg
     1081 gggaacgcgc aggagctgta cctcggcagc ctcgccgcgc tcggcatcga cctgcgcgcc
     1141 cacgacgtcc ggttcgtcga ggacgactgg gcgtcgccgg cgctcggcgc gtgggggctc
     1201 ggctgggagg tgtggctcga cgggctggag atcacccagt tcacctactt ccagcagtcc
     1261 ggcgggatcg cgctcgaccc cgtctcggtc gagatcacgt acggcgtcga gcgcatcatg
     1321 atggcgctgc agggcgtgtc ccacttcaag gacatcgcct acgccccatc catcggcacc
     1381 gcccgagggg ggacgacccc ccacgccccc cgggccgact ccgtcggcat ctcctatggc
     1441 gaggcgttcg ggcaggccga gtacgagatg agccgctact acctcgacga cgccgacatc
     1501 gcggcgaacc gcgagctgtt cgagacgtac gcgtccgagg cgcgccggat gctggacgcc
     1561 cggctgcccg tccccgccca ctcctgcgtg ctgaagtgct cgcacgcgtt caacgtgctg
     1621 gacgcgcgcg gcgcgatcgg caccgccgag cgggcccgcg cgttcgcgcg gatgcggggc
     1681 ctcgcgcacg aggtcgccgc cctgtgggtc gagcgccgcg ccgaactcgg ccaccccctc
     1741 ggcgacgcca ccgtcttcga gatcgccctg gagaagacgg tcctccgcga gatcgccgca
     1801 ccggccgcgt tcgcgctgga gatcggcgtg gaggaactgc cgtcggccga ggtgcgcccc
     1861 gcggcggagg ccgtcgcgga gcggctccgc accggactgg aggcggcggg cctgctcacc
     1921 gacgcctccg ccgtcgacgc gttctcgacg ccccgccgcc tcatcgccgt cgtccgggac
     1981 gtggagccga agtccccgga caccgaggag gtcgtgaagg ggccgaggct cgccgccgcc
     2041 tacgacgcgt ccggggagcc gacgcgggcg ctgctcgggt tcgcgcgcgg gcagggcatc
     2101 gacgccgccg acgtgcgggc gatcaccgtc ggcggcaagg agtacgcggc gcacgtccgg
     2161 acggtcgccg ggaagcccgc cgcgcaggtc ctctacgggc tggtccacga gatcgtctcc
     2221 gggctgcgcg ccggcaagaa catgcgctgg aacctccccg gcctgtcgtt cgcgcggccc
     2281 gtccggcggg tcctcgccct gctgggccac cggcagatcg tggtggacga gctgaaccgg
     2341 ggccggacga ccgacgtcca ccgcgccgcc gacccgtccc gggtcccggt gccggacgcg
     2401 ctgtcgctga tcggcgtcct gcgggagcac ggcatcgagc ccgaccccgc gcggcgccgc
     2461 acccgcatcg tcgaggacgc gcggacgctc gccgccggcc acggcgggac cgtcgacgcc
     2521 gccgcggagg aggacctcgt cgaggagatc gtcgacctgg tcgaggagcc cgtcgcgatc
     2581 ctcgggtcgt tcgacgcgaa gtacctcgac ctgcccgagg cgatcctcac caccgtcatg
     2641 cgcaagcacc agcggtatct gccggtgcgc gggccgtccg gcgagctcct cccgcacttc
     2701 gtcaccgtcg cgaacggaga atgcgaccac gacgtcgtcc gggccgggaa cgaggccgtc
     2761 atccgcgccc gctacgagga cgccgcgttc ttcttccagc aggacctgcg cagcaggccc
     2821 gaggagatca agcacgggct cgatcggttg accttcaccg aacggctcgg ctccatggcc
     2881 gaccgctcgt cccgcatcgc cgcgatcgcc gccgacctag ccgaccgcct cgacctcccg
     2941 cccggcgagc gcgcggtcct cgaccgcgcc gccgcgctcg ccaagttcga cctggcctcg
     3001 gccatggtca tcgagctgcc gggcctcgcc gggacgatgg cgcgcgagta cgcccggcgc
     3061 gccggggagg acgccgccgt cgcgcaggcc ctctccgaga tggagctgcc gcgctcggcc
     3121 ggggacgcgg tccccgcgac cgccgcgggc gccgtgctcg ccgccgcgga ccggctcgac
     3181 ctgctcgccg ggctgttcgc ggtgggcgcc gcgccggccg gcgggtccga cccgttcggg
     3241 ctgcgccgcg ccgcgctcgg gctgctcgcg atcctgcggg ccgtcccgtc gccggccgcg
     3301 gccccgctca cggtcggcgg cgggctcgcg atcgcggccc ggcaccagcc cgtcgaggtg
     3361 ccgccggagg cgctcgccga ggcggagcgg ttcaccgcgc ggcggctgga gcagagcctg
     3421 ctggacgagg ggctgccgat cccggcggtg cgggccgtcc ggccgctcgc cggcgacccg
     3481 gcccgcgccg cccgcgccgc gtccgacctg gcgggactgc tccgcacgga cgagttcgcc
     3541 cggctcacca cggcgctgca gcgggtgctg cggatcgtcc cggaggggac ggaggccggc
     3601 tacgaccgcg gcctgttcgc cgagcccgcc gaaggccgcc tcgccgaggc gttgtcgcgg
     3661 ttccgcgacg cgctcccgcc gcgtccttca ctgccggagt ccgtgtcggc cgccgccggg
     3721 ctgcccgccc cgatcgacgc ctacttcgac gacgtcatgg tcatggacaa ggaccccgtg
     3781 ctgcgcgcga accggctcgg cctcctcgcc gcgatccgcg acctcgtcgc tcccgttctc
     3841 gactggcggg aggtcggtta gtaccaggtg aaggggaggc cgtggggcgg ggcctccccg
     3901 aggacgcgcc gctcgccgcc cggccacagg cgcagggtca gcagcggggt gccggtgatg
     3961 tgcgcggtgc cgggcggctc gaacgccagg tgcgcgaccg gcgcgccgga ggacgccgcc
     4021 gcgccggccg cctcgacgtg ccggtggacg cgcgcggcct cctcgtccgg caggtactgc
     4081 atcatgaccg agtgccagac gacggtgacc gcgccgggct cgggcgccag gccgtcgagg
     4141 aagtccccgg caccggcccg caccaccgcc gccgggaccc gcgccgccac ctccagcgcc
     4201 gcccgcagcc gcgcgacgcg ggcgtgctgg tcgggccaca cgtacgacag cagccgccgc
     4261 cgtccctcgg gcgcggcggc gtcgagcggg gcgaggtcgc agccgagccg cgcggcgatc
     4321 cgcagcggga cggccttcgg cggcgtgccg cgccacgcgt ccggcaggac gaccggcgag
     4381 tccggcccgt acccgccgcc cgggaacagc agccggtagt ggtcggcgcg caggttcagc
     4441 ccggcgctcg cgccgatctc cagcagccgc accggcagcc cggtcgcggc ggcgaccgcc
     4501 agcagcccgc cgaccagcgg cgcggcccgg ccgacctcgt tggtctgcgg cgcgtcggcg
     4561 agcccggcgc ggacctcggc ggtgcgccgg gccaggacgt cgcggaacgc gggccatgcg
     4621 gcgagcgggt cggcggtgcc gccggccgtc gggtagtgcg cggcgagcgc gggcgcgcgg
     4681 ccctccagca cgatccggtg gacggtgccg agcatccgca gcgcgagcgc gctggacgcg
     4741 cggtccgcga gcacgtccgc gacgggcccg ccggcgtccg cgtcgtccgc cgcccgcgcc
     4801 agcagctccg cgtacatcgg cgatccctgc gcggcgcaca cccgcgcctg gtcgagcagt
     4861 tcctcgcgca ccccgcgcac cccgccacct cccggccgcc gccggtccgc ccgtccggcg
     4921 gccccgtctt cgtcaacagt caccgttgtc ccgcccgcgt cccgcggtca tgatcaagat
     4981 acctgggatg gaaggggtca aaggtgacga acctccacga tggacgggac taccgcgcgc
     5041 acggctggtg gcgggacggg acgttcctgg acgacctcgc cgcgcgggcc gccgccgcgc
     5101 cggaccggcc ggcggtcgtc agccacttct gggagaccgc cggcggcccc gacaccgtgc
     5161 tgacctgggc gcagctgcac gagcgggtgg agcgctgcgc cgccggcctc gccgcgctcg
     5221 gcgtgcggcc cggcgaccgg gtcgcgatgc agctggtcaa ccagtggcag gcgaccgtcc
     5281 tcgcgctcgg ctgcggccgc gcgggcgcgg cggtcgtccc gtactacatc gcctccgggc
     5341 ccgccgacac cgagtggatc ctgcgcgagt ccggcgcgtc cgcggtggtg tcgctggacg
     5401 aggtgcgcgg cctcgacatc gccgcgacca tcgccgggat gcgcgaccgg ctgcccgcgc
     5461 tgcggcacca gatcgtcgtc ggggagaagg tccccgaggg cgccgtcggg ttcgaggacg
     5521 ggctgctcgc ctccgacgcc gcgccgcccg cgcaccgtcc cggcggcgac gacgtcttcc
     5581 agatcatgta cacctcgggg acgaccggcc gcccgaaggg cgtccggcac tcgttcaaca
     5641 ccctgtacgc gatggcgcgc tcgttcaccg tcccgctcgg gctcggaccc gacgacgtgc
     5701 tgtccacgcc gtgcatcgtc ggcgggcagg gcggctggct gtacgggatg ctcgcgccgc
     5761 tcgtcgcggg cgcggcggcg gtgtgggcgg acgcgttcaa gcccggcgac ttcctcgacc
     5821 tcgccgccga gtacggcatc acgaccgcgt acttcacccc gctgatcctg gacgagctgg
     5881 tcgccgagca gcgggagaac ccgcgcccgc tcgcgctgcg gcacatggtc accggctcca
     5941 cgccgatccc gcccggcctg cccgcgcggt tccgcgagac gttcgggttc cccgtccgcc
     6001 cgctgtgggg gatgaccgag aacggcggcg tcaccatagg ccgcgccgag gacccgccgg
     6061 actgggcggc gcgcagcgac gggcggccgg tcgactggat ggaggtccgg ctggtcggcg
     6121 aggacggcgc gccggtcgac ggcccgggcc ggctggaggt gcgcggcgcg aacctgtgcc
     6181 tcggctacga gggcgccgac gacgtcttcg ccgcgtcgct gcacgacggc tggttcgtca
     6241 ccggcgacct cgcccggccg gacggccgcg gcggcatcaa gatcatcggc cggaccaagg
     6301 acctgatcaa caagggcggg ctgcacgtgc ccgccgtcgc cgtcgaggag gtgctgcgcg
     6361 cccacccgaa cgtcgcggag atcgcggtgg tcggcgagcc cgagccgctg ctcggcgaga
     6421 ccgtcgtcgc cgtcgtcgtc ccggcgggcg acccgcccgc cctggaggac ctgcaccggc
     6481 tcgtccggga ggcggggatg acccccggct acgagccgga ccggctggag gtcgtcgccg
     6541 agctgccgaa gacgccgacc gggaaggtcc gcaagcgcgc catcgaggag gatctcgccc
     6601 gccgggcgag cgccgccgcc gcgccgtgat ccccgcgcgc cgccgggcgc tggcgctgac
     6661 gtcggtgatc ctcgccaacg tgatggcggt gatcgactac aacgtcgtca gcgtcgcgat
     6721 cccgcggctg ctgcgcgcct accccggcag cacgctcacc gggctgtcct ggacgatcac
     6781 cggctacacc gtcgtgttcg ccgccgtgct gctgcccgcc ggcggcatgg ccgaccggct
     6841 cgggcccaag cggatcttcc tcgccgggct cgcggtgttc accgccggct cggccgcctg
     6901 cgcgctcgcg cccggcccgc tcgggctggt gctcgcccgg ctgctgcagg ccgcgggcgg
     6961 cggcgcggtc gtcgcgctgg cgatctccgt cgggctcagc gaattccccg gccgcgcggg
     7021 gcacgccttc gggctgctcg gcgcggtgtc ggggatcgcc ggcgcgagcg ggcccgcgct
     7081 cggctccgcg ctgatggcgc tcggcggctg gcggtggatc ttcctgatca acctgccgct
     7141 cggcgcgctc gcgctggcct gcggcgccgc gggcatcccg gccgggacgc ggaccggacg
     7201 gggcctgccc gacctcgccg gggtggcgct gctcgcgggc ggcgtcgccg cgctggtgct
     7261 cgggctcgtc cagggaccgg tgtggggctg gacgcatccc ggggtcctcg gggccgcggc
     7321 cggcggcacc gcgctgacct ggctcggtgt gcgccggtcg ctgcggcacc cgcgccccgc
     7381 cgcggacttc gcgctgctgc gcgccgcgtc gacggcggcg ggcaacgcgg cgatggcgct
     7441 gatgagcgtc acccagttcg cggtcgcgct gtgcgttgcg ctgttcctca ccgagcggtg
     7501 gggctactcc gcgctgaccg ccgcgctcgc cctcaccccg ggcccgctga cctccgccgc
     7561 ggtgtcctgg tgcgccgggc cgctggtgcg gcgggcgggc gcgcgggccg tcgccgtcgc
     7621 gggcgggctc accggcgccc tcggctggtg ctggccgctc gccgccggcg ccgccggggc
     7681 gggacgcgac tacgccgtcg ccgtgctgcc cgcgctcgtt gtcggcaccg ccggcatggc
     7741 ggccacggcg gtcgcggtgg agacgatcgc gatgcgggcc gtcccgcccg cccggtacgg
     7801 cagcggcagc gcgctgatca tgctggcgcg gtcggcgggc gccgccgccg gcatcggcgg
     7861 cctcgccgcc gtgctgcacg agccgtcggc gcgcgggttc gacgcggcgt gggcgggcct
     7921 ggccgccgga atgctcgccg cggccctcgc gggcgccgcc gggcagcgcg gcgcccgcga
     7981 ccccgatagc ggccgcgggc gccgccgcgc cgtttccgcc gaaggcgggg cgcgaccctg
     8041 atcaatggcc tggacggtcg gcccggaatt caccgggagc cgcggcggcc attagtccgc
     8101 ccggcgggcg ggccattgcc gcgataccgt catgccattt tccgaaatga attgtcacca
     8161 cggcttcgtg cgcatgcgtg tcacctcccc gcgctcgccg gaacctcgcg tgcgggcgct
     8221 cgtcaccacg ggggcgtgcg catcgccttc acctcccctt cggccgggtc gggcgggaca
     8281 cgggcgatca ccacggagtc gtgcgcatgc cggtcacctt cccttcggga gcaccggggc
     8341 ccggcgttcg cggggcccgc catcggaggc ggtgcgccgg gcgcccgtcc gggggcgccc
     8401 ggcgcaccgg tcaaaggctc agcaggacga agtgctgggg gaggtgcacc gccagcccga
     8461 gcggcatcga cgcggtgatc gtcaccgcgt ccccgtcgcc gcgcagcgcc agcaccgact
     8521 cctcgccgtc cagcagcgtc acgcccgcgc ggaagtcgcc gagcagcacc cggtcccgcg
     8581 cgatcatgcg ggtgcgggtg atccgcaggc ccgccgagtc cagcgcgggc agcgcgcccg
     8641 cgccgacgag ccgccagtac agcgccgggt gcatgaccag cccgtcgcag gacccgccgg
     8701 tctcctccac ctcggcgcac gccgccatca gcgcgtccag cgcggtgccg gccggggcgt
     8761 ccaggacgtc gggcgcgggc agccggcgca ggccctccag gttcagcagg ccggtgatcg
     8821 cgccgtcgcc gctgccgtgc agcagcacct cgttctccac cgtgcacagc cggacgatca
     8881 cgcggtgctc gacgaagcgc gccagcaggg cggggtcgcg gcgcagctcg gcgggcaccg
     8941 cgacggccac cgagatctcc gtcagctcgg ccttggccgc cgacgcgcgg aacaccgcct
     9001 cgggcgtcgc ccggtaggcg gtcccgctcg caccgccgcc ctcgccgggc agctcgcgca
     9061 cgtaccgcag cggcccgccg gtgacggtgc cgcccttggt ctgctcccgg acggtcggcc
     9121 ggggccgcgt cgaggccagc gggaacagcg cggtcagcgg cctgcggacg cggaccgcgg
     9181 cgtcgccgcc ggccgcccgg gccaccgcga ccgccagctc ctcgcccggc ccgcgctcgc
     9241 gcagggcggg gtcgtcgatg aggtagtcca gcacgggagc tcccatcacg cgcgccccgc
     9301 gccgtcccgg ttctcgggcg ggcgggccgc gcggcgccga tgccgcacgg tgcgatcttg
     9361 cgccgtgcca gcctgagagt aagcaatgtc cggcgaaatg aaaagggccc gggatgttct
     9421 tgtcggacga aattcatcgt gatagaacgg ctttgcggat tggacttctc cggcccggga
     9481 cggtgaatac atgcggcacc ccgaaaaaca gggtgggcgg gccgccgcat tcgccgaccc
     9541 gatcatcgac gaacgcaccg ggaccggcac caggccggcg gcccggcccg cccccggctg
     9601 cccgctgcgc gccgccgccc tcgccgccga ggccgccgag gctcacagca ccgaggccgc
     9661 ggacggcccg gcccggcagg ggagaccgcc ggccggggcg ccgggcgacg gccgatgagc
     9721 accgcggccc ccgcgctcgc cgccgtcccg tggcggcgcc gcccgccccg gcgaggcggg
     9781 cgacgccgaa cccgagtggc accgccggtt ccgcaccgcc tgggagacgc cgccccgcgc
     9841 cccgtccacc gatgacctcg ggctgctgga ggcggcccgc ccgctcatcg acgacgcgcg
     9901 ccgcacgctg cgcgaatgcc tgctgtccga cctcggaccc gacctcccgg acggcctgcc
     9961 cggcctcctc gccgccgcgc ccccgctcgg ctggctcacc atggccgtcc agcccgccct
    10021 cgccgaggag ctggcggcgg cgtccgcccg cggcctcgac ggcggcacgc cgcaggaccg
    10081 gtacgcggcc ttcgtgcgcg gcctcgccga ccccgcgcgg gcgctgcgga tctgggcggc
    10141 gtaccccgtc ctcgcgcggc aggtcgtcga gatcctggac gactgggtgg cggcgcggct
    10201 ggcgttcgcc cgcgagctgg ccgccgacct gcccgccgtc accgccgcgt tcggcgggag
    10261 ggagggcctc ggcgcgctca ccggcgtcga gttcgggcag gcggagacgc accgcggcgg
    10321 ccgcaccgtc gcgatcgtcc ggttcgagcg cgccgtcctc gtccacaagc cccgccccct
    10381 cgccgtcgac ctgtgcttcg accggctcct cggctggttc aacgacgccg gcgtcccgca
    10441 cccgctgcgc cggccgcgcc tcctggaccg cggcgaccgc ggctggagcg agtacatcga
    10501 gcccgcgccc tgcgcgcccg gcgacctccc cgcgttcttc tggcgcatgg gcgcgctgct
    10561 cgcgctgacc cacgcggtgc acggctacga cctgcacgcc gacaacgtga tcgcggcggg
    10621 cgcggacccc gtcgtcatcg acctcgaagc gctgttccac acgtccggga cccagccggg
    10681 cgtccgccgc gcccggctcg gcgacccggc ggcggagcgg ctggaggcgt ccgtgctgcg
    10741 caccgggctg ctgcccggcc cgctcgtcat gccggacgtg ggcaccgagc ggcccttcgg
    10801 cgtcgacatc agcccgctcg ggaccgtccc cgaccgccgc tccctcatcc cgacgccgct
    10861 ggtcgacgac cccggcaccg accggatgcg ggtccgcctc ggctaccgga ccgtcccgcc
    10921 gccggccggg cggctccggc tcccgggcgg cggcaccgtc gacccgcgcc cgcaccgcga
    10981 cgcgctcgtc gccggctaca ccgccgccta ccgccgcctc gcgtccgccg ggaccgggct
    11041 cctggcgccc ggcgggccgc tgcacgggtg cgccgacgtg cccgtccggc tgatccagct
    11101 gtcgacgttc ctctacgtcc ggctgctgct ggagagctgg cggccggacg cgctccgcga
    11161 cgccgcccag ggggagcgcg gcctcgcccg cctcgacgcc ggctggcccg gcgtcccgca
    11221 ccgcgacgcg ctcgtcgccg ccgagaaggc cgcggtgtgg cgcggggagg tgcccgtctt
    11281 cgaggtccgc cccggccacc gggacgtctg gctggaggac gggacgcgcc tcccggacgt
    11341 gctgcccgtc ccgccgctgg aggagaccgc cgcccggctc gccgcgctgg acgaggacga
    11401 cctcgccgtc cagaccggga tcatcgacgc gagcctcgcc gcgctgccgc ccgcccccgg
    11461 cccctcgccc gtgcgggcgc cgcggccgtc cggcgacccg ctgcgcgacg cgctcggcat
    11521 cgcccggcgg ctggacgcgg cggcggtccg ctccggcgac cggatcggct ggctcggcat
    11581 cgaggtcgtg gacgcgcggg cgcgccgcgt cgcgcccgcc gggctcggcc tgtacggcgg
    11641 cctgcccggc atcgggctgt tcctcggcca cctgtcggcc gtgaccggcg aatcgtgggt
    11701 cgccgggctc gccgaacgcg tcgccgacga ggtcgccgcg cggctcgccg ccgcatccgg
    11761 cgtcccggga acggtcccgc cgctcggccc cgtctaccat ctcgcgcacg ccgccgccgt
    11821 ccacggccgc cgcgacctcg ccgaggcggc ccgcgacgcg ctgctcccgg ccccgcccgg
    11881 cccgccgtcc ggcgacgtcc tggaagggga ggcgggcgcg ctgctcagcg ccctcgccct
    11941 gcacgccgtc ctgcccggcg agcaggtcgc gggcatcgcg cgggccgccg gcgagcggct
    12001 cctcgcccgc gacctgaccg ggccggggtt cgggtacggc gcgtccggcg ccgcggtcgc
    12061 cctcgcccgg ctggacgcgc tgtgccccga cccccgcttc gcgtcccgcg cgctgtccct
    12121 cgccgccgcg gagcgcgcac cgggcaccga tcccggctgg tgccagggcg cggcgggcgt
    12181 cgcgctcgcc cgcctggaac tggccgcccg gtacccgtcg gccgccgccc ggctggagca
    12241 gccccttgag gccgcggcgg ccgtcctccg gaacgccgct gcccccgacg actcgctctg
    12301 ccacggcacg tccgccgtcc acgaggcgct cgccgccctc gacgaacccc ttccccgcca
    12361 acctcacggc gccctgcgca ccgccctgcc cgagcccgcc cccggcctgc tcgccggcct
    12421 gtccggcatc gggtacgcgc tgctgcgccg cgcccgcccc gccgaggtgc cgtccgtgct
    12481 cgcgctggcg ccgcccgccc cctccagcct cctgttcccc ccagaggaga cgccatgacc
    12541 gtggacgttc aaccgggacc gctcgcgatc gacggcgccg aacccgtgcg caccgacccc
    12601 tggcccacct acgacaaggg cgacgtcttc atcgaggagg aggacctgga ggccgcgctc
    12661 gacgccgtcc gggcccgcct ctacttccgc tacgaccacc gcccccatgc cgagacgcgg
    12721 accgggcggc tggagcggga gctgtgcgcg ttcttcgccg ccccgcacgc gctggcctgc
    12781 gcgagcggca ccgccgcgat caccctcgcg ctgctcgcgc tggacctgcc gcccggctcc
    12841 ctgatcgcct gccccgcgtt cacgttcgcc gcgacgccca gcgcgatcct gctggccggg
    12901 caccggccgc tgctcgtcga gtgcgacgac gacctgcacc tggacgtcgc cgacctgcgc
    12961 cgccgcctca cccccgaggt ccgcgccatc gtggtggtgc acatgcgcgg gttcgcctcc
    13021 gacatggacg cgatctgcgc cgtcgcccgc gagcacggcg tcccggtcgt cgaggacgcg
    13081 gtgcccgcgc tcggcgcccg gctcaacggc cgcccgctcg gcacgttcgg cgacgccggg
    13141 gcgttcagca cccagtccga caagtcgctc aacaccggcg agggcgggtt cctgctcgcc
    13201 cgcgaccccg ccgtgcacgc ccgcgcggtc gtctactccg gcgcctacga ggggcggatg
    13261 gcccggcact tcgacggcgc gccgccgccc gtcgacgacc tcgcctaccc gatcttcggg
    13321 ctgcggatgg acgagatccg cgcggcgctg gcgtccgcgc tgctgcggcg gctgcccgag
    13381 cggctcgccg cgcaccaccg caactacggc gacgtcgccg ggcggctcgc ggacgtcccc
    13441 ggcatcgcac tgcgccgccc cgtcgccgac cacgcctacc tcggcgaggc gctggtgttc
    13501 cggctgcccg gcgccggcgc cgacgccacc gcctggaccg ccgccgcgct gcgcgccgag
    13561 ggcatcgacg cccgcgcgct cggcgacccc ggcgacacca acgtgcgcgc cttctggaac
    13621 tggcggttcc tgttccccga ccccgcgcgc gcccgcgccg agttccccgt caccgccgcg
    13681 cgcctggacg agtccgtcga cgtcccgctg tcggccaacc tcaccgaacg cgaccgcgac
    13741 cacctggtga cggcggtgcg gaaggtggtc ggggcgggac gctgctgatg gtccgcgtcc
    13801 tctacgtgac cggctggtgc cgcagcggga cgacgctgct cggcaacctg ctgggggagt
    13861 gcggcggcgt cgtgcacgtc ggcgagctcc gctacctgtg gacgaacggg atcctcggcc
    13921 gcggcaccaa cgcgctgtgc ggctgcgggc tcgacgtcgc gtcctgcccg ctgtggaagg
    13981 gcgtcgtcgc ccgcgtcgcc ggcgacgatc ccgggtggca cgccgagcgg gccgtccggc
    14041 tccagcaggc cgcgctgcgc acccggcaca ccggccgccg cctcgccgag gcgcgcggcg
    14101 cccgcgccgg ccatcccgcc gtctccgccc tcgccgcgct gtacgcggcg atcgccgagg
    14161 agtcgggggc gcggctgatc gtcgacaccg gcaagttccc ggcggaggcc gcggcgctgt
    14221 gcggcgcgcc gggcgtggac gcccgcgtcc tgcacgtcgt ccgggacccg cgcgccaccg
    14281 ccgagtcatg gcggcgcgcc aaggagtaca tccccgcgat gggcgccgcc cgcagcaccg
    14341 cgtactggac cggcttcaac ctcgcctcgg agcggatcgc gcgcgcgttc ccgcgccgct
    14401 gcctgcggct gcgatacgag gacttcaccg ccgacccgcg cgggtcgctc gcccgcgtca
    14461 tggcgcacgc cgggctggac ggcgacccgc ccgtcggcgc ggacggccgc gcggacctcg
    14521 gcgtcaacca caccgtcacc ggcaacccgg accggctgcg gcgcggcgcc gtccgcatcc
    14581 gggaggacga cgcgtggacc cgcacgcagc ccgcgcccgc ccgcctggtc gccaccgcgc
    14641 tcgcgctgcc gctgctggcc cgctaccgct acccgctcgt cccggcggcg gcgcaccagg
    14701 ggcgccgggc gccggacacg cggtcgccgc gcagggaggg agcggcctga tggacctcgg
    14761 actcaccgga cgcgtcgcca tggtcgccgc cgcgaccagc ggcctcggcc tcgccgccgc
    14821 ccgcgagctg gccgccgccg gcgccgacgt cgcgatctgc gggcgcgacc ccgaccgcct
    14881 cgaccgcgcc gccgccgaga tcgacaaggc cgggccggga cgcaccgtcc ccacccggct
    14941 ggacgtcctc gaccacgacg cggccgccgc ctgggccgac cgcaccgcca tcgatctcgg
    15001 cggcccgcac gtcctggtca ccaacgcggg cggcccgccc ggcggccccg tcctcggccg
    15061 gagcctggac gacttccgcg cggcggtcga gctgagcgtg ctcagccacg tcgcgctggt
    15121 ccaggcggcg ctgccgcaca tgcgggacgc cggctggggc cgcgtcctga tgatcgcctc
    15181 ggagacgatg cggcagccga cgccccgcta cgggctgtcc agcacggtcc ggcccgcgct
    15241 cgccggattc gcccggacgc tggtccgcga gctcgggccc gccgggatca ccgtgaacgt
    15301 gctcgcgccc ggctaccacc ggacgcccgc cgtcgcgtcg atgccggacc tcgacgaggt
    15361 cgccgcgtcc atccccctcg gccgcctcgg ccgcccgtcc gacttcggcg cggtcgccgc
    15421 gttcctcgcc ggcgagcagg ccggcttcat caccggcacc acgctcgtcg tcgacggcgg
    15481 cctcggccgg gggatctgat ccggaaggag cccgatggac ttcgacgacg tgctcgccgc
    15541 ccgccggatg gtgcgccgct accgccccga ccccgtcccc gccgacgcgg tcgagcggat
    15601 cgccgccatg gtgcgcaagg cgcccagcgg cggcttcagc cagggccacc gcctcatcgt
    15661 cgtcaccgat cccgtgaccc gcgcgcggat cgccgaactg gcccaggagc cgtactacac
    15721 gcgcgacggc gagccgccgt ggctgtcggt cgcgcccgtc ctgatggtgc tcggcatctg
    15781 cgaggacgac taccacgccc gctacaccaa gcccgacaag ctggtcgacg gccaggagat
    15841 ggagtggccc gcgccctact ggtgggtgga ctccggcgcc ctgctgatgc tgatccagct
    15901 cgccgcgatc aacgagggcc tcgccagcgg cttcgccacc gtccccgcca aggacgagct
    15961 ggccgccctc ctcggcgtcc cgccggagat cgcgatcgtc ggcgtcatca ccatcgggta
    16021 cgcccgcgcg gacgccgtcc gccccgccga caccgccagg ctccgctcga tgcgcaagcc
    16081 gttcggggac ctcgtccgcc acgagtcgtg gaaggacggc gcgcgccccg ccggaacccc
    16141 ctgatcacgg cggcggccgc cgtcccggat cgcggacgcg ctctcagatg ctggacgcgg
    16201 tcacgggcgg gggcgcggag tcaataggat cgtcggcatg ctgcgctggt tgaccgcggg
    16261 ggagtcccat ggcccggccc tgaccgcgat cgtggaaggg ctgccggccg gcgtgcgcgt
    16321 gacctcggcg gacatcgccg aggacctgcg ccgccggcgg ctcggccacg ggcggggcgc
    16381 ccggatgaag ttcgagcagg accaggtgac gatcctcggc ggcgtccggc acgggacgac
    16441 cctcggcggg cccgtcgcga tccaggtcgg caacaccgag tggcccaagt gggagacggt
    16501 catgtcggcc gaccccgtgg accccgacgt cctcgccgcc caggcccgca acgcgccgct
    16561 gtcgcagccg cgccccggcc acgccgacct cgtcggcatc cagaagtacg gcttcgacga
    16621 cgcgcggccc gtcctggagc gggcgagcgc gcgggagacc gcggcgcgcg tcgcgctcgg
    16681 caccgtcgcc aaggcgttcc tcaagcaggc gctcggcgtg gacgtgctga gccacgtgat
    16741 cgcgctcggc gaggtcgagg cgcccgacgg ggtgctgccc ggcccggacg acctcgccgc
    16801 cgtcgacgag agcccggtgc gctgcttcga cggcgccgcg tccgccgcga tggtcgcgca
    16861 catcgacgag atgaagaagg ccggcgacac cctcggcggc gtcgtcgagg tcctcgccta
    16921 cgggctcccg ccgggcctcg gcagccacgt ccactgggac cggcgcctcg acgcgcggct
    16981 cgcgggcatc ctcatgggca tccaggcgat caagggcgtc gagctcggcg acgggttcac
    17041 caccgcgcgc cgccccggct cccgcgcgca cgacgagatc gacaacaccc ccgacgggat
    17101 ccgccgccgc accaaccggg ccggcggcgt cgagggcggc atgaccaccg gcgaggtgct
    17161 gcgggtccgc gccgcgatga agccgatctc caccgtgccg cgccggctcg acaccatcga
    17221 cgtcaagacc ggcgagcccg ccaaggccat caaccagcgc agcgacgtca ccgccgtgcc
    17281 cgccgcgggc gtcgtcgccg aggcgatggt cgcgctggtg ctcgcggacg cggcgctgga
    17341 gaagttcggc ggcgactccg ccgaggagac cgcccgcaac ctgcggggat acctgtcctc
    17401 gctcaccatc aagtgaagtg gaccggcgca ctatgacgcg accgaaggcc gtcctgatcg
    17461 ggccgcccgg atcgggcaag accaccgtcg gcaccgccct cgccgagcgg ctcggcgtgc
    17521 cgctgcgcga caccgacgcc gacaccgagg ccgccgccgg caagccgatc ggcgagatct
    17581 tcatcgacga cggcgaggag cgcttccgcg agctggagcg cgccgccgtc gccgcggccc
    17641 tcgccgagca cgagggcgtc gtcgcgctcg gcggcggcgc cgtcctcgcc gccgagacgc
    17701 aggagctgct cgccgggcac accgtcgtct acctcaaggt cgggctctcc gaggcgatca
    17761 agcgggtcgg gctcgcgtcc gcgcggccgc tgctggtgct gaacccgcgc agccagatgc
    17821 gcaagctgct ggaggagcgg ctcccgatct acgagcggct cggcaccctg cacgtcgaca
    17881 ccgacgggcg cgagcccgcc gacgtcgccg aggagatcgt caaggcgctg gaggcggcat
    17941 gacctcggcg cgggtccacg tcggcggcgc cgacccctac gacgtcgtca tcggcaccgg
    18001 cgtcctcgcc gagctgcccg cgatggtcgg cgaccgcgcc cgcacggtcg cggtggtgca
    18061 cgccgagggg ctccccgaga tcgcccgccc ggtctgcggc gcgctggagg aggcggggta
    18121 cgcggtgctc gcgctgcccg tcccggacgg cgaggccgcc aaggaggccg gcgtgctcgc
    18181 cgggctctgg tcggcgttcg cgcgggccgg gatgacccgc accgacgccg tcgtcggcgt
    18241 cggcggcggc gccaccaccg acctcgccgg gttcgcggcg gcgtcgtggc tgcgcggggt
    18301 gcgctccgtg ctcgtcccga cgacgctgct cggcatggtg gacgcggcgg tcggcggcaa
    18361 gaccggcatc aacgtccccg agggcaagaa cctcgtcggc gcgttccatc cgcccgcggg
    18421 cgtgctgtgc gacctcgcca ccctcgtcac gatgccgcgc gaggactaca tcagcggcct
    18481 cgccgagatc atcaaggccg gcttcatcgc cgacccgaag atcctcgacc tcgtcgagga
    18541 cgaccccgag ggcgccgcgt ccccggccgg gccgcacacc cgcgagctgg tcgaacgcgc
    18601 gatccaggtg aaggcggacg tcgtgtccgc cgacctgaag gagagcggcc tgcgggagat
    18661 cctcaactac ggccacaccc tcgcgcacgc catcgagaag gccgaggact acaagttccg
    18721 ccacggccac gccgtcgcga tcggcatggt ctacgccgcc gagctcgccc gcctcgccgg
    18781 ccggctgccc gccgacgtcg tccggcggca ccgcgacgtg ctctcctccg tcggcctgcc
    18841 cgtctcctac gccgccgact ggcccggcct gcgcgcgacc atgaccatcg acaagaagtc
    18901 gcgcggcgcc acgctccggt tcgtcgtcct cgacggcatc gccgagcccg gccgcctcga
    18961 aggcccggac gaggacctgc tcgccgccgc ctaccaggag gtctcccgat gagccgggtg
    19021 ctggtgctga acggcccgaa cctcggccgg ctcggcagcc gcgagcccga ggtgtacggc
    19081 tcgacgacgc tcgacgacct cgccgcgctg tgccgcgaca ccggccaccg cctcggcctc
    19141 accgtggagg tccggcagac cgacgacgag gctgagctga tccgctgggt gcacgaggcc
    19201 gccgacgagc ggctcccggt cgtcctcaac ccggccgcgt tcacccacta ctcctacggg
    19261 ctgcgcgacg ccctcgcgca gcgcaccgcg ccgctcgtcg aggtgcacat cagcaacccg
    19321 gcgacccgcg aggagttccg ccacacctcc gtcgtcgcgg gcgtcgccac cgggaccatc
    19381 gccggcttcg gcatgatgtc ctacgtcctc gccctccagg cggtcgccga actcctcgcc
    19441 gaatccccct gaccccgccc cagcgcccca agcgccggcg gcactctaag tgccccacgc
    19501 gccggcggtg ctcttagcgc cccacgcgcc ggcggcgttc ttggcgctcc acgcggcggc
    19561 ggcgttcttg gcgctccacg tagcggcggt gctcttggcg ctccacgcgg cggcggtgct
    19621 ctgagccccc caggcggcgg cgctctttac gcggtgcccg gagcggagcg ccagcggagc
    19681 gtagggctcc gctcaatcct cttggacggc gttccgcgtc atctccttga gctcggcgac
    19741 gacgtcgtcg agcggcgcga cgtcgcggtg ggcgcggcag aggatcgtcg cgccctcgac
    19801 ggcggcgacg atgaggcggg cgaggcgggc ggcccggtcg tcggggacgc cggcgttgcc
    19861 gagcccggtg gcgagcgtgt cctgccagcg gtcgaacgcg gccgcggcgg cggaggccag
    19921 ctgcggggcg tcgtcgtggc tctccacggt gacggcgacg atcgggcagc ccgcccggaa
    19981 ctcgctcttg atcagcacct gccgccacca gccgacgaag gcgtccacgg cggacgcggc
    20041 gtcgccgccc tcggtggcgg cgaggatgcc cgcgttgagg aactcgccgg cgtagcggac
    20101 ggcctcctcg gcgagctgcg ccttgccgtc ggggaagtgg tggtagatcg acccgcgcgg
    20161 cgcgccgctg tgcgcgatga cgtcgcggaa cccggtgccg ctgtagccgc gctcgcggaa
    20221 gagataggcg gcgctgcgca ccatgcgttc ccggctgtcg gtgcccatgc ctcgattatg
    20281 acattcatca taagcttctc gcattgacca tgacggtcgt catagcccac cgtgcttatg
    20341 acggacgtca tacctagagc atccggaggg ggagcgatgg cgggcacggc gaccacggcg
    20401 ggcctcgagc agctcaaggc gctgatcaac aagggggccg aggagggcta cggcatcggc
    20461 gcgctgctcg gcatggcggc ggaggcgctg gagccgggac gcgtcgtctt ctcgctcgcg
    20521 ccgcgcaccg acttcagcaa cccgctgggc accgtgcacg gcggcgtgct gtccacgctg
    20581 ctggactcgg cgatgggctg cgcggtgcac acctcgctgc cggagggcgc gggctacacg
    20641 acgctcgagc tgaaggtcaa cttcgtccgc gcggtgccgc tggagggtgg caggctgacc
    20701 tgcgagggaa cgaccgtcca tgtcgggcgg aaggtcgcga ccgccgaggg gcggatcgtg
    20761 aacgcggacg gcaagctcgt cgcgcacggc acgacgacgt gcatgatctt cccgccggct
    20821 accgaccagt agggtcggtt cgggcaccga cacgaaggag accagcgtga tcgatctgcg
    20881 gcgcgacggc gacgtccacg tcctgcgctt cgacgacggc gagaaccggt tcagccccga
    20941 cttcctcagc gccgtcgaag gcgcgctcga caccgtcgag aagagcgagg gtccgggcgc
    21001 cctggtcacc accgggacgg gcaagttcta ctccaacggc ctcgacctgg actggctcgg
    21061 cgcccaccgc gacgagttcg agccgtacct cggccggatc cacgcgctct acgcgcggct
    21121 gctggagctg ccgatgccga cggtcgccgc gctcaacggg cacgcgttcg cgggcggcgg
    21181 catgctcgcg ctcgcccacg acttcgccgt catgcgcacc gaccggggct acttctgcct
    21241 gcccgaggtc gacctcggca tgacgttcac gccgggcatg aacgccctga tcggcgcgcg
    21301 gctgcccaag cgcaccgcgc acgaggcgat ggtcaccggc cgccggtaca ccgccgacca
    21361 ggcgatggcg gccgggatcg tgcagcgcac cgccgacgag gcgggcgtgc tgccggcggc
    21421 gctggagctg gccgggtcgc tggccggcaa ggacggccgg gtggtgggcc ggatccgcgc
    21481 cgacctgttc cggcccgcgc tggaggcgct gcgcggcccg gcgctcggct agccgcgggc
    21541 cgcgcgcccc ggcggcgggc cctcgccccg gcgggcggcg cggagtaggt tacgttcact
    21601 ggaatctgat tcggttttac gggaagggac gccggatgcg catcgggatg gggctcaact
    21661 acgcgggcag cggcttcaag gacaccgtcg aggagctcgc cgacttcgag aaggccggcc
    21721 tcgacatcgt ctacgtgccg gaggcctaca gcttcgacgc ggtcagccag atggggtaca
    21781 tcgcggccaa gaccgagcgg ctggagatcg gctccggcat cctgaacatc tactcccgga
    21841 cccccaccgc gatcgcgcag accgccgccg gcctggacta cgtctccgat ggccgcttca
    21901 ccctcggcat cggcgcgtcc ggcccgcagg tcatcgaggg cttccacggc gtcccctaca
    21961 ccgcgcccct cggccgcacc cgcgagatca tcgacatctg ccgcaaggtg tggcggcgcg
    22021 agcgcgtcca gcacgacggc aagcactaca cgctgccgct gcccgccgag aagggcaccg
    22081 gcctcggcaa ggcgctcaag ctgatcaacc acccggtgcg cgccgagatc ccgatcatgg
    22141 tcgccgcgat cggcccgaag aacgtcgagc tcaccgccga gatcgccgac ggctgggagc
    22201 cgatcttcta catgccggag aaggccgccg acgtgtgggg cgcctcgctc gccgccggca
    22261 aggccaagcg cgacccgtcc ctcggcgagc tcgacgtcgt cggccaggcc gcgctcgcca
    22321 tcggcgacga cgtgcagggc ttcctggagt tcggccgccc gatggccgcg ctctacatcg
    22381 gcggcatggg cgccaagggc aagaacttct acaacgacct cgcccgccgg tacggcttcg
    22441 agaaggaggc cgaggagatc caggacctct acctcgacgg caagaaggac gaggccgccg
    22501 cgaaggtccc gcaggagctg ctggagaaga tgtcgctg
//
