LOCUS       NZ_CP053892            21110 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9035813
            Orig. end                         :: 9056923
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..21110
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="26"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21110
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21110
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11110](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11110)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(871..891)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.12"
                     /tool="antismash"
     misc_feature    884..900
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.01"
                     /tool="antismash"
     gene            complement(908..1690)
                     /locus_tag="ACTIVE_RS40690"
                     /old_locus_tag="ACTIVE_8166"
     CDS             complement(908..1690)
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853361.1"
                     /locus_tag="ACTIVE_RS40690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8166"
                     /product="thiazole synthase"
                     /protein_id="WP_281382749.1"
                     /transl_table=11
                     /translation="MTETANDALVIAGEEIGSRLITGTGGAPSMQVLREALTASGTALT
                     TVAMRRVDPSARGSVLNVLTGCGIRVLPNTAGCFTAGEAVLTAKMAREALGTNWVKLEV
                     IADERTLLPDPIELVEAAEQLVDDGFVVLPYTNDDPVLAHRLEQLGCAAVMPLGSPIGS
                     GLGIRNPHNIELIVERAGVPVILDAGLGTASDAALAMELGCDAVLLATAVTRAQSPARM
                     AAAMRHAVEAGRLARLAGRIPKRRYAQASSPFEGLASS"
     gene            complement(1694..1894)
                     /gene="thiS"
                     /locus_tag="ACTIVE_RS40695"
                     /old_locus_tag="ACTIVE_8167"
     CDS             complement(1694..1894)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017541361.1"
                     /locus_tag="ACTIVE_RS40695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8167"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_173099938.1"
                     /transl_table=11
                     /translation="MRIIVNGEPRELPDGASVAQAVAAVTAAASGVAAALNDEVVRRSA
                     WEATTLREADRLEVLTAVQGG"
     gene            complement(1894..3018)
                     /gene="thiO"
                     /locus_tag="ACTIVE_RS40700"
                     /old_locus_tag="ACTIVE_8168"
     CDS             complement(1894..3018)
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853359.1"
                     /locus_tag="ACTIVE_RS40700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8168"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_173099939.1"
                     /sec_met_domain="DAO (E-value: 8.2e-73, bitscore: 245.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIAIIGAGVIGLATAWRAAQGGAAVTLVDPAPASGASSVAAGML
                     TPVSELSYGEEPLLRLGLASRDRYGAFAAELAEATGLDTGYRDDGTLQVAFDADDLKLL
                     DDLRAFQEGLGIPVEALTGRECRRAEPMLAPGVRGGLLAPEDGSVDPRRLAPALLAAGE
                     RLGVRLVRRRAEGVLVERDAAVGVRLDDGTEIRADRVLLAAGPWSGDLAGLPPGTVPPV
                     RPVKGQVIRLRTPVPFLRRTTRGLVKGSSVYLVPRADGEIVIGATQEELGFDTRVTAGG
                     LWELLRDARELLPGITELEFAEVTAGLRPGSPDNAPLMGPTALPGFYLGTGHFRNGILL
                     APVSADALAAMLLDGPVPEVAAPFSPARFSTEVQ"
     misc_feature    3006..3018
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.82"
                     /tool="antismash"
     regulatory      complement(3009..3122)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(3039..3052)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    3117..3126
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 12.77"
                     /tool="antismash"
     misc_feature    complement(3146..3161)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.83"
                     /tool="antismash"
     gene            3231..4454
                     /locus_tag="ACTIVE_RS40705"
                     /old_locus_tag="ACTIVE_8169"
     CDS             3231..4454
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658557.1"
                     /locus_tag="ACTIVE_RS40705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8169"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_173099940.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.6e-45, bitscore:
                     154.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRVIVVGGGLAGVRAAEALRSKGYEGALTLVSAERHMPYDRPPL
                     SKAVLAGDSDDTTVDADWDALRCDLLLGERATALRLAEPGRGGTVASTAGDLPFDGLVI
                     ATGAEPVTLPGDGHQHVLRTIDEARDLRERLTEGARIVIVGAGWIGAEVATAAAKKGCA
                     VTVVEAADTPLAGAIGPEVGALTAPWYAEAGVALRTGVKVAAVEHGGLALAGPGGGERI
                     DADEVVVGIGVRPALGWLDGSGLLLERGVVTDGSFRTVTDDEAGAVRPDVVAVGDCAAW
                     WSGRYGRRLLVEHWDTALNAPDVAAAALLGQDAAYDAVPYFWSEQFGRMVQYAGDHTRS
                     ERLVRRGDPSGRKWAVAWLTGDRLDAILTVDRPRDLVQARRVIAAGTPVDPDAVADPDV
                     PVRQAVRG"
     gene            4524..4907
                     /locus_tag="ACTIVE_RS40710"
                     /old_locus_tag="ACTIVE_8170"
     CDS             4524..4907
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658558.1"
                     /locus_tag="ACTIVE_RS40710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8170"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_173099941.1"
                     /transl_table=11
                     /translation="MTQTHATVDSALDPRTDALAGDWLSLRETAERLGIKTSRIKQLIS
                     ERKLLAVRRGGEPMVPAAFIRDGQVIKGLSGTLTLLSDAGFDEVETIRWLFTADDTLPG
                     TPVQALSENRGTEVRRRAQALAF"
     gene            5004..5675
                     /gene="thiE"
                     /locus_tag="ACTIVE_RS40715"
                     /old_locus_tag="ACTIVE_8171"
     CDS             5004..5675
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853356.1"
                     /locus_tag="ACTIVE_RS40715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8171"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_173099942.1"
                     /transl_table=11
                     /translation="MSRHIPTERAVALRARLSRARLYLCTDARERQGDLPAFLDAVLGN
                     GVDIVQLRQKGLEARQEMACLEVFRAACERHGALLAVNDRADVARAVGADVLHLGQDDL
                     PVPAAREIVGGDVLIGRSTHSDEQASAASAEPGVDYFCAGPVWPTPTKPGRPAPGPKLL
                     EYVAAQRQPRPWFGIGGIDLGNLGEVLEAGAERVVVVRAITEAADPGAAAAEFARRLAA
                     A"
     misc_feature    5739..5754
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.05"
                     /tool="antismash"
     gene            5749..5910
                     /locus_tag="ACTIVE_RS40720"
                     /old_locus_tag="ACTIVE_8172"
     CDS             5749..5910
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630836.1"
                     /locus_tag="ACTIVE_RS40720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8172"
                     /product="hypothetical protein"
                     /protein_id="WP_173099943.1"
                     /transl_table=11
                     /translation="MSVGPDDDRPVDLGDDLEILPDQTSDDTDAGWGEWRGGGDDDARL
                     IEERPPHW"
     gene            complement(5917..7032)
                     /locus_tag="ACTIVE_RS40725"
                     /old_locus_tag="ACTIVE_8173"
     CDS             complement(5917..7032)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853354.1"
                     /locus_tag="ACTIVE_RS40725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8173"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_246342490.1"
                     /sec_met_domain="Pkinase (E-value: 2.7e-42, bitscore:
                     144.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPHDTSRGRTTPHTARSAQSRNGQQSRGGQGRAGQAHGRPAKPRS
                     GQAAQGAGKRPAARQGGGRRHERPLSSGDPRSIGGYRLLGRLGEGGQGVVYLGRDGDGG
                     LVTVKVLRGGLDAGQRARSRFVKEADAARKVAGRHTARVLDADVTGDRPYIVSEFVEGP
                     PLQRVVAEDGPLPAPQLRKVALRTAGALAAIHRAGIVHRDFKPANVVLGPDGAKVIDFG
                     IARAADALARTEPLTTSPIGTPGYMAPEQIEDEPVGPPADVFAWGAAMVFAATGRPPFG
                     TGPSAAVMRRVTSRPPDLGEMDGPLRDLAARCLDKNPAARPTAPQLVRALREGQGPAPK
                     PRPTRIPRYRWRMMLALAVVIIAGFALGVLF"
     gene            complement(7119..9311)
                     /locus_tag="ACTIVE_RS40730"
                     /old_locus_tag="ACTIVE_8174"
     CDS             complement(7119..9311)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658561.1"
                     /locus_tag="ACTIVE_RS40730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8174"
                     /product="glycoside hydrolase family 3 C-terminal
                     domain-containing protein"
                     /protein_id="WP_173099944.1"
                     /transl_table=11
                     /translation="MRRTGRRTGNPTGLRSERWTPAAAALVSVLALAAPLSGAVPAGAA
                     QTRCGDPAQRPWCDASLGADRRTALLMAKMTGDEKIAMLASDDPLGGPLGGFIDTAHAD
                     TGNGVPRLGIPPVYMADGPAGVRQGKATRLPAPISLAAGFDPAAARLYGGTVGWEARHR
                     GNDLIFGPTVDVLRAPRNGRSFEGFGEDPYLSSGLGAEWIRGAQAQGVMASVKHLAVYT
                     QESDRLSLDMKVDPRTLREVYLPPFEAAVKQGGAATVMCGFGKLNGRWACQDGGVLNGI
                     LRSEWGFKGFVPSDHTAVQDTVAAANGGLDMELPIGMKYNAFLLKMAVAQKKVTQAAID
                     GHVRNVLRTMFAFGVFDRAAYPNDLAAIDRTTSGTAARTIAEGGITLLRNAGGILPLRS
                     PSSIALIGRAAQQSQSGTGSANVVPFASVSAQDGIARRAGSGTKITFNNGDDAGAAADA
                     ARKADVAIVFATDSEGEFFDRSCLTLKCGDPLRGDQDALIGTVAKANPNTIVVLQTGGA
                     VLTPWRNQVKGIVEAWYPGQEGGNALARVLYGDVDPGGRLPVTFPAAENDAPTAGNPAQ
                     FPGVNKTVTFSEGVMVGYRHYDAKGLTPAYPFGYGLSYTTFKYGGLTASSTSVQVTVTN
                     TGTRAGTAVPQLYLGLPSPGVDVPQPPRQLKGYAKVQLAPGQSKRVTFPLTSRSLAYWN
                     QGAKAWKVAGGCYKVMVGGSERGIEQTGSFGTCTAG"
     gene            complement(9311..9853)
                     /locus_tag="ACTIVE_RS40735"
                     /old_locus_tag="ACTIVE_8175"
     CDS             complement(9311..9853)
                     /GO_function="GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1298: putative carboxymuconolactone decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630833.1"
                     /locus_tag="ACTIVE_RS40735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8175"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_173099945.1"
                     /transl_table=11
                     /translation="MCADIPGERAPRLAPLPEAEWDGTLRAVAATTGPLNVFTTLGRHP
                     RLFEKWIGFGTALLMKGLLGDRDRELAIMRTAHLRDCAYEWGHHRRLALAAGLSEAEIA
                     ALRLPLDDHGWSDDDLMVLTAADELDERSTLTDATWAALSARFGERELIELVMLIGHYH
                     MVAFALNALRVQDEEGH"
     gene            complement(10001..11110)
                     /locus_tag="ACTIVE_RS40740"
                     /old_locus_tag="ACTIVE_8176"
     CDS             complement(10001..11110)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017541915.1"
                     /locus_tag="ACTIVE_RS40740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8176"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_173099946.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.5e-47, bitscore:
                     161.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSLPAGGRPIASPGSLHSSWSRIRKQVDEALPAFVDRQRPGLLA
                     ISDDLGPLLSALDALLAGGKRLRPAFCYWGWRAAGGGTDDPAIVHAAASLELLQASALI
                     HDDVMDSSDTRRGQPSVHRRFEALHRAHGWPGAAGPFGTGTAILLGDLCLSWSSEMFET
                     CGLDEERRSRGRAVYDLMRTEVMCGQYLDMLEGTRGGATAETALRVVEFKSAKYTVERP
                     LHLGAALAGADPRVTAALTGYGLPLGIAFQLRDDVLGVFGDPAETGKPAGDDLREGKRT
                     VLVALTLERATDAQAAALERRLGDPELDRPGVDEARTIIEETGGLAACEAMIDGYLDEV
                     GRALAGAPVAEDARDALAELAIAATARRT"
     misc_feature    11154..11169
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.99"
                     /tool="antismash"
     misc_feature    11161..11175
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.69"
                     /tool="antismash"
     gene            11305..12240
                     /gene="metF"
                     /locus_tag="ACTIVE_RS40745"
                     /old_locus_tag="ACTIVE_8177"
     CDS             11305..12240
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630831.1"
                     /locus_tag="ACTIVE_RS40745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8177"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_173099947.1"
                     /transl_table=11
                     /translation="MRPVRPDRPPTVRELLASGERSFSFEFFPPKTDKGARNLWRTIRE
                     LEPLHPTFVSVTYGAGGGTRDTTVDIVERIATDTTLTPVAHFTAVNHSQAELRNLIGRF
                     AAAGVRNVLALRGDPPGDPMGEWVKHPEGVEYAAELVRMIRSYGDFSVGVAAFPYKHPR
                     SPDVESDTRYFVEKCRAGADYAITQMFFRAEDYLRLRDRVAATGCATPIIPGIMPVTKY
                     STIERSEQLSGAPFPPEVRARFDAVADDPDAVRRLGIEHAAELCRDLLDEGAPGIHFIT
                     FNQSTATREVYGLLESGGYGAKGSVPPMTA"
     gene            complement(12177..12779)
                     /locus_tag="ACTIVE_RS40750"
                     /old_locus_tag="ACTIVE_8178"
     CDS             complement(12177..12779)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630830.1"
                     /locus_tag="ACTIVE_RS40750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8178"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_173099948.1"
                     /transl_table=11
                     /translation="MRDPKLREIDERAFLRRLNPMLEVYRAAMEPPDEQLPGRHTIMER
                     HAAYPSFRAFVAERRGALPGLPGPVHGFAYGFRGARGQWWHDVVYQALADLGGEEHAAT
                     WMDDSFEVAELHVHPQAQGRGLGRALLTSLCEGRPERTVVLSTLDKRPETPARHLYRSV
                     GMVDLLSDFEFPGGGPRYAVMGGTLPLAPYPPDSSSP"
     gene            complement(12790..13122)
                     /locus_tag="ACTIVE_RS40755"
                     /old_locus_tag="ACTIVE_8179"
     CDS             complement(12790..13122)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630829.1"
                     /locus_tag="ACTIVE_RS40755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8179"
                     /product="hypothetical protein"
                     /protein_id="WP_173099949.1"
                     /transl_table=11
                     /translation="MAAPPPPGSLPPPYTAAGAAQLPPGEQPNPEYERLYHAYADAYGS
                     IDGVRRALDAPVRTLGSTDAWLGPEARAWGGQLDGQRGALQKAADRILWDIYDRLSSTQ
                     RTTSRV"
     gene            complement(13135..14088)
                     /locus_tag="ACTIVE_RS40760"
                     /old_locus_tag="ACTIVE_8180"
     CDS             complement(13135..14088)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS40760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_8180"
                     /product="hypothetical protein"
                     /protein_id="WP_173099950.1"
                     /transl_table=11
                     /translation="MTAQMRTGPAARDPDFRGIDPPALAQVIKQLRDAQAAISGWLNGH
                     RPPAGVSQAGYRQADQVAHWVSGQLGMLERRYNFAVSHPDPGGGVDAPPVPRPAPAPKR
                     TGGTPGGTPRPVRPPGRTSPVHKVAPTPHGAGDLGGYPDRPAAQKAARADALAVAAAVR
                     GGKAVPDAVWKRLKADAGDPDYTETLYARLGPEGAAGLVGAAHGDAARLKVIQESLGTS
                     SRHLTIDVKWLRAFLAEADRAGVRPSAVRVVTEADLSARTREAVARLHLDGTVHAEAAP
                     PDGQAAPHHPAGTQQHPTSTPQHPTSIPKSTPSTVA"
     gene            complement(14161..14511)
                     /locus_tag="ACTIVE_RS40765"
                     /old_locus_tag="ACTIVE_8181"
     CDS             complement(14161..14511)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853348.1"
                     /locus_tag="ACTIVE_RS40765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8181"
                     /product="arsenate reductase family protein"
                     /protein_id="WP_173099951.1"
                     /transl_table=11
                     /translation="MEIWHNPRCSKSRAAKAALDEAGVEYTERRYLDEPPTAEELDAVL
                     TRIGAEPWDVARLNEPVAKELGLKDLEHDRARWIEVMVANPVLIQRPIVLTGGEAVVAR
                     DPDSVKKALDSR"
     gene            complement(14523..14987)
                     /locus_tag="ACTIVE_RS40770"
                     /old_locus_tag="ACTIVE_8182"
     CDS             complement(14523..14987)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291495.1"
                     /locus_tag="ACTIVE_RS40770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8182"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_173099952.1"
                     /transl_table=11
                     /translation="MHPNVERVAAALRGHGAAGEIVELPDSARTAQAAADQLGCEVGAI
                     ANSLVFDADGAPLLVMTSGAHRVDTGKVALLVGAEKVKRATPEFVRAATGQPIGGVAPV
                     GHPAPIRTLVDVWLDKYEEVWAAGGHPHTVFPTSYAELLRMTGGDPAEVG"
     misc_feature    15119..15134
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 25.93"
                     /tool="antismash"
     misc_feature    complement(15120..15133)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 24.0"
                     /tool="antismash"
     gene            15269..15751
                     /locus_tag="ACTIVE_RS40775"
                     /old_locus_tag="ACTIVE_8183"
     CDS             15269..15751
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853345.1"
                     /locus_tag="ACTIVE_RS40775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8183"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_173099953.1"
                     /transl_table=11
                     /translation="MSATMAARGVHSAAQPAPGPRHRALPAPRPVHTAVGQLHAARMGL
                     AEAAEATSPAVRYVCAHLAALRAAAAVLASKEPLETHRRGRPRSVWVLLPEAEPALREW
                     AAFFAAGADKRAAAEAGLPRAVTPREAEELLHDAEVFVTLVEDTLGVTSQPTLPTP"
     gene            15982..17178
                     /locus_tag="ACTIVE_RS40780"
                     /old_locus_tag="ACTIVE_8184"
     CDS             15982..17178
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854940.1"
                     /locus_tag="ACTIVE_RS40780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8184"
                     /product="CoA transferase"
                     /protein_id="WP_173099954.1"
                     /transl_table=11
                     /translation="MENDATPPLAGLRVVELSSFVASPLGGMSLAQLGADVIRVDQIGG
                     GPDIDRWPLAPSGRSLYWAGLNKGKRSFTADLRSAEGRALVARLAADAGVVLTNAPPRD
                     GLTYEALRELRPDLIHVQLLGTREGGNAVDYTVNAAVGFPSLTGPAASAEPSNHVMPAW
                     DVACGLYLAIGLLAAERHRLRTGEGTRLRVALSDVALATAGNLGMLAEAQLGQVRPRLG
                     NHLFGDFGRDFATADGRVMVAVLTARHWRDLVAATGLTEVADALERALGADFRTAGDRY
                     AYRDALGGVLAPWFASRTCAEVEDGLKGTSVLCSRYRELAEVAAGLHDEPLMGEIDQPG
                     IGRHLAPASPMRLGDAVPAPAPAPELGQDTGEILRDVLGVPDEEAADLRARGVAGEPG"
     misc_feature    17247..17261
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    17252..17266
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.56"
                     /tool="antismash"
     gene            17317..18561
                     /locus_tag="ACTIVE_RS40785"
                     /old_locus_tag="ACTIVE_8185"
     CDS             17317..18561
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="ACTIVE_RS40785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8185"
                     /product="cytochrome P450"
                     /protein_id="WP_173099955.1"
                     /sec_met_domain="p450 (E-value: 5.1e-10, bitscore: 37.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDAGLEQSATAPIRHPLDSDAEGVNRPGLHKNARYHEIRETGT
                     GVAEVTRHDGTVAKLVTRYHDVEQVLRNQEVFSREAALDADAVDLEGTMLGLDLDDHAA
                     VRGAVKDWFSPQAVERLRAVAGERAAEALAAMRGAGEPADLVTAFALPFSLDLICDMMG
                     LPREDRLRFHGWGDAFLGTSEQTRVNAEESQVAMVTYLAGLVAERGGGTADDLLTHIAA
                     GAAGLSFDRQVKLPMTLVLGGWETVASSIGTQVHVLLTHPYEGHETAYAYLTAHPEAVP
                     GAVTEMERLFSTTAADDLPRRVTREVTLPSGARLEPGELVIPSHDAANCDPRVFDDPHR
                     MDFARTPNRHLSFGYGPHHCIGRHLGHMEVVTAVALLTRELPSLRLAVPSEEIQRKPGH
                     VINGPSALPVAWSPA"
     gene            18631..20043
                     /locus_tag="ACTIVE_RS40790"
                     /old_locus_tag="ACTIVE_8186"
     CDS             18631..20043
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853344.1"
                     /locus_tag="ACTIVE_RS40790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8186"
                     /product="MFS transporter"
                     /protein_id="WP_246342491.1"
                     /transl_table=11
                     /translation="MTARGGRGLVPLLAFLGMMAYSLSMAVVTPALALIQQGLHTTAAG
                     AAWAITAMTLSAAVATPVVGRLGDLYGPRRVLLAVLAIATVGMVIAAAAGSLPLMLVGR
                     MLSGIGGGVFPLAYTIIRDVYPPARTASAVGLMSSMLGLGGAVSWCLAGPIIDLLGWRW
                     LLWVPVAGLVPGVLLAWWIVPASPPREAAKVDWWGAALFGGWLVAALTALTEGMDWGWT
                     SPGVLGLLGLAALLALVWLRVEARVAEPLVDLRLMRVRGVWTANAASLLSGYALMAGGL
                     LFPLLVQLPASTGYGFGGTATQAALLQLPASIGMTAAGMTAGLLDRRIGSRLVLLGGAV
                     LTAAGYAFVVVEHAAMWQLYVGGLGRGIGLGFAYAAVANLVVAAVPAGETGVATGINTL
                     IRTVGASLGTQVSAVIVAGLPGERGFSAGFAVSSAVMVAVLPLALLVPPRARRSGKGAP
                     CRGEERSAAPVT"
     gene            complement(20135..20629)
                     /locus_tag="ACTIVE_RS40795"
                     /old_locus_tag="ACTIVE_8187"
     CDS             complement(20135..20629)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622275.1"
                     /locus_tag="ACTIVE_RS40795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8187"
                     /product="transcriptional regulator"
                     /protein_id="WP_030145002.1"
                     /transl_table=11
                     /translation="MPSEYAKALGARLRAIRTQQGLSLHGVEEKSRGRWKAVVVGSYER
                     GDRAVTVQKLAELADFYGVPVSELLPGGAAPSPLGPTPKLVIDLERLQQLPKDKAGPLA
                     RYAATIQSQRGDYNGKVLSIRQEDLRSLAVIYDKSPTELTEELITWGVLDPEARRAVES
                     F"
     misc_feature    complement(20610..20624)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.18"
                     /tool="antismash"
     misc_feature    complement(20778..20791)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.29"
                     /tool="antismash"
     misc_feature    complement(20779..20792)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.59"
                     /tool="antismash"
     misc_feature    complement(20903..20918)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
ORIGIN
        1 ggtggtgaag gcgatcgcgg tcgggaagac gccgaggtag accatgttca gggtcgcgcc
       61 ggccggcgcg tgcgcggcct gcgagaccag ctgcggcgcg aacggcaggc agacgaccgt
      121 gccgacggcg cacgcccagg tggtgaactg cagcggcgac gcgtgccgga gcgcgggctt
      181 ctggctgacg acgccgaacg cgtaggtgat cgcggcgacg acgcacagca gcacgccgcc
      241 gaccggggag cctccgccgc cggacatcga cagcccgacg atcgcggcgc ccgcgaacga
      301 caccgccatg ccggccagca gccgcggcgc gaagccctcc ttcagcagcc agccgccgag
      361 cagcgcgatc aggatcgggc cgatgttgac gacgagggcc gcggtgccgg cgtccacgag
      421 ccgctcgccc cagttcagcg cgaccatgta ggcgccgaac cacagcacgc ccgccgcggc
      481 gatgccgggc caggcgccct tcggcggcag gccctcgcgg cggacgacgc agaggaccgc
      541 gagcacgacg gtcccggaca gcagccggcc gagggcgagg gcgccggggc cgtactccgc
      601 gccggcgctg cggatcgcga cgaacgccga ggcccacagc acgacggtga cggccgcggc
      661 cgcgacggcg agccggtcga cgccggtccg ctgggctccg tccccgagag cggcaccgtc
      721 ctgctgcctg acactggcct gttgcatgtg acgcacctta ggttcgcgac tcttccatga
      781 acaccgaagg atgcggccag gttgcggcgt catctcccgg tggacgcccc tcagtctgcg
      841 gacgcccacc gttcaggtcc agcgaatatt tcttcagccg aagctttagt tctgcttcat
      901 cgaccggtta ggacgaggcg agtccctcga acggcgagga cgcctgggcg tagcggcgct
      961 tcgggatccg gcccgccagc cgggccagcc gcccggcctc gacggcgtgc cgcatcgccg
     1021 ctgccatccg cgcgggcgac tgcgcgcggg tgacggcggt cgcgagcagc accgcgtcgc
     1081 agccgagctc catcgccagc gccgcgtcgg acgcggtgcc gagccccgcg tccaggatca
     1141 ccgggacgcc cgcccgctcg acgatcagct cgatgttgtg cgggttgcgg atgccgagcc
     1201 ccgacccgat cggggagccc agcggcatga ccgccgcgca gccgagctgc tccagccggt
     1261 gcgcgagcac cgggtcgtcg ttggtgtagg gcagcacgac gaagccgtcg tcgacgagct
     1321 gctcggcggc ctccaccagc tcgatcgggt ccggcagcag cgtccgctcg tccgcgatca
     1381 cctcgagctt gacccagttc gtgccgagcg cctcgcgcgc catcttcgcg gtcagcacgg
     1441 cctcgcccgc cgtgaagcag cccgcggtgt tcggcagcac ccggatgccg cagccggtga
     1501 ggacgttcag caccgagccg cgcgccgacg ggtcgacccg ccgcatcgcg accgtggtca
     1561 gcgccgtccc ggacgcggtc agcgcctcgc gcagcacctg catgctgggc gccccgccgg
     1621 tgcccgtgat cagccgggag ccgatctcct cgcccgcgat caccagggcg tcgttcgccg
     1681 tctccgtcac cggtcagccc ccctgcaccg cggtcagcac ctcgaggcgg tccgcctcgc
     1741 gcagcgtcgt cgcctcccac gccgaccggc ggacgacctc gtcgttcagc gcggcggcca
     1801 cgccggacgc ggcggcggtg acggccgcga ccgcctgcgc caccgacgca ccgtcgggca
     1861 gctcgcgcgg ctctccgttc acgatgatcc tcatcactgc acctcggtgg agaaacgggc
     1921 gggggagaag ggggccgcga cctcggggac gggcccgtcc agcagcatcg cggcgagggc
     1981 gtcggcgctg accggcgcca gcaggatgcc gttgcggaag tggccggtgc ccaggtagaa
     2041 gccggggagg gcggtcgggc ccatcagcgg cgcgttgtcc ggggagccgg ggcgcaggcc
     2101 cgcggtgacc tcggcgaact ccagctcggt gatgccgggc agcagctcgc gggcgtcccg
     2161 cagcagctcc cacaggccgc ccgcggtgac ccgcgtgtcg aagcccagct cctcctgcgt
     2221 cgcgccgatg acgatctcgc cgtccgcgcg cggcaccagg tacaccgacg agcccttcac
     2281 caggccgcgg gtggtgcgcc gcaggaacgg caccggcgtg cggagcctga tcacctggcc
     2341 cttgacgggg cggacgggtg gaacggtccc gggaggcagg cccgcgaggt cgccggacca
     2401 cggcccggcg gccagcagca cccggtcggc gcggatctcg gtgccgtcgt ccaagcggac
     2461 cccgacggcg gcgtcgcgct cgaccaggac gccctccgcg cgccgccgca ccagccggac
     2521 gccgagccgc tcgcccgccg ccagcagcgc cggggcgagc cggcgcgggt cgaccgagcc
     2581 gtcctcgggg gcgagcaggc cgccgcgcac gccgggcgcg agcatcggct cggccctgcg
     2641 gcactcgcgg ccggtgagcg cctcgacggg gatgccgagg ccctcctgga aggcgcgcag
     2701 gtcgtccagg agcttcaggt cgtcggcgtc gaacgcgacc tgcagcgtgc cgtcgtcgcg
     2761 gtagccggtg tccaggccgg tggcctcggc cagctcggcg gcgaacgcgc cgtagcggtc
     2821 gcgggaggcg aggccgagcc gcagcagcgg ctcctcgccg tagctgagct cgctgacggg
     2881 ggtgagcatg cccgcggcga ccgacgaggc gccgctcgcg ggcgccgggt cgacgagggt
     2941 gacggcggcg ccgccctgcg cggcccgcca ggcggtggcc aggccgatga ccccggcccc
     3001 gatgatcgcg atctgcaatg cgcgctccct tcgccggcat gatccggatc aggtcgtggc
     3061 ggtcggcggc ccgctcagcc gccctctcag cccggtcgca ccggactccc gcgccctgtt
     3121 gtgttatgca cgtgccgtta tgtcccccac catacggcca acggccggaa tgcacctgtc
     3181 tggacacccg tccaaaagcg ctccggcggg cccggttagg gtgggcgccc atggacaggg
     3241 tgatcgtcgt gggcggcggg ctggcgggcg tgcgggccgc cgaggcactg aggagcaagg
     3301 ggtacgaggg cgcgctgacc ctcgtctcgg cggagcggca catgccctat gaccggccgc
     3361 cgctgtcgaa ggccgtgctc gcgggcgact ccgacgacac caccgtcgac gcggactggg
     3421 acgcgctccg ctgcgacctg ctgctcggcg agcgcgccac cgcgctgcgc ctggccgagc
     3481 ccggacgcgg cggcaccgtc gcctccaccg ccggcgacct gcccttcgac ggcctggtca
     3541 tcgccaccgg cgccgagccc gtgacgctgc cgggcgacgg gcaccagcac gtcctgcgca
     3601 ccatcgacga ggcccgcgac ctgcgcgaac ggctcaccga gggggcccgg atcgtgatcg
     3661 tcggcgcggg ctggatcggc gccgaggtcg ccaccgccgc cgcgaagaag ggctgcgccg
     3721 tcaccgtcgt cgaggccgcc gacaccccgc tcgcgggcgc gatcgggccc gaggtcggcg
     3781 cgctcaccgc cccctggtac gccgaggcgg gcgtcgcgct gcgcaccggc gtcaaggtcg
     3841 ccgccgtcga gcacggcggg ctcgccctcg ccggccccgg cggcggcgag cggatcgacg
     3901 ccgacgaggt cgtcgtcggc atcggcgtgc ggcccgcgct cggctggctg gacggctccg
     3961 gcctgctgct ggagcgcggc gtcgtcaccg acggctcgtt ccggacggtg accgacgacg
     4021 aggcgggcgc cgtccgcccg gacgtcgtcg cggtcggcga ctgcgccgcc tggtggtcgg
     4081 gccgctacgg gcggcgcctg ctcgtcgagc actgggacac cgcgctcaac gcccccgacg
     4141 tcgccgccgc ggcgctcctc ggccaggacg ccgcctacga cgccgtcccc tacttctggt
     4201 ccgagcagtt cggccggatg gtgcagtacg cgggcgacca cacgcgctcc gagcggctcg
     4261 tgcgccgcgg cgacccgtcc ggccgcaagt gggcggtggc gtggctcacc ggcgaccggc
     4321 tcgacgcgat cctcaccgtc gaccggcccc gcgacctggt gcaggcgagg cgggtgatcg
     4381 ccgccgggac gccggtcgat ccggacgcgg tcgcggaccc ggacgtgccc gtccgccagg
     4441 ccgttcgcgg gtagcggaac ctcaccgccg gtaacggcgg ccgggcgggt ttgagggttc
     4501 cgaaggcgtg gtagcaaggg ggcgtgaccc agacgcacgc aaccgttgac agcgcactgg
     4561 acccccgcac cgacgccctc gccggcgact ggctctccct ccgggagacg gcggagcgcc
     4621 tcggcatcaa gaccagccgg atcaagcagc tcatcagcga gcgcaagctg ctggcggtcc
     4681 gccgcggcgg cgagccgatg gtgccggcgg cgttcatccg cgacggccag gtcatcaagg
     4741 gcctgtccgg cacgctgacg ctgctgtcgg acgccggctt cgacgaggtc gagacgatcc
     4801 gctggctgtt caccgccgac gacacgctgc ccggcacgcc cgtccaggcg ctcagcgaga
     4861 accgggggac cgaggtgcgg cgacgcgccc aggccctggc attctgaccc gcacgcccac
     4921 ccgaccagag cgaccggccg cggggccgcg ccgacgtgcg cggccccgcg ccgcatgccc
     4981 cgcgaaagga aaccgccccc accgtgtcca ggcacatccc gaccgagagg gccgtggcgc
     5041 tgcgcgcccg gctcagccgc gcccgcctct acctctgcac ggacgcgagg gagcggcagg
     5101 gcgacctccc cgcgttcctg gacgcggtgc tcggcaacgg cgtcgacatc gtccagctgc
     5161 gccagaaggg cctggaggcc cggcaggaga tggcctgcct ggaggtgttc cgggcggcgt
     5221 gcgagcggca cggggcgctg ctggcggtca acgaccgcgc cgacgtcgcc cgcgcggtcg
     5281 gcgccgacgt gctgcacctc gggcaggacg acctgccggt cccggccgcc cgcgagatcg
     5341 tcggcgggga cgtgctgatc ggccggtcca cgcactccga cgagcaggcg tccgcggcgt
     5401 ccgcggagcc gggcgtggac tacttctgcg cgggcccggt gtggcccacg ccgaccaagc
     5461 cgggacgtcc cgcgcccggc ccgaagctgc tggagtacgt ggcggcgcag cgccagcccc
     5521 ggccctggtt cgggatcggc ggcatcgacc tcggcaacct cggcgaggtg ctggaggcgg
     5581 gcgccgagcg cgtcgtggtc gtccgggcga tcaccgaggc cgccgacccg ggcgcggccg
     5641 ccgcggagtt cgcccgccgg ctcgccgccg cctgaccggg cgggggtccc ggccgggcga
     5701 cggggatcac ggtgcgggcg gccgccccga tgaccgacaa tggggatcat gagcgtggga
     5761 cccgacgacg accggcccgt cgacctcggc gacgacctgg agatcctgcc ggaccagacc
     5821 tccgacgaca ccgacgccgg ctggggcgag tggcgcggcg gcggcgatga cgacgcgcgg
     5881 ctgatcgagg agcgcccgcc gcactggtga gcgccgctag aacagcacgc cgagcgcgaa
     5941 cccggcgatg atcacgacgg cgagcgccag catcatccgc caccggtagc gcgggatgcg
     6001 ggtcggccgc ggcttcggcg ccgggccctg cccctcgcgc agcgcgcgga cgagctgcgg
     6061 cgcggtgggc cgggcggccg ggttcttgtc caggcagcgg gcggcgaggt cgcgcagcgg
     6121 cccgtccatc tcgccgaggt cgggcggccg cgacgtgacc cgccgcatca ccgccgcgct
     6181 cggcccggtg ccgaacggcg gccggccggt cgcggcgaac accatcgcgg cgccccaggc
     6241 gaacacgtcg gcgggcggcc cgaccggctc gtcctcgatc tgctcgggcg ccatgtagcc
     6301 gggcgtgccg atcgggctcg tggtgagcgg ctcggtgcgg gccagcgcgt cggcggcgcg
     6361 cgcgatgccg aagtcgatca ccttggcgcc gtccgggccg agcaccacgt tggcgggctt
     6421 gaagtcgcgg tgcacgatcc cggcgcggtg gatcgcggcg agcgcgcccg cggtgcgcag
     6481 cgccaccttg cgcagctgcg gcgcgggcag cggtccgtcc tcggccacga cccgctgcag
     6541 cggcgggccc tcgacgaact cgctgacgat gtaggggcgg tcgccggtga cgtcggcgtc
     6601 cagcacccgc gcggtgtgcc gcccggcgac cttccgcgcg gcgtccgcct ccttgacgaa
     6661 ccggctgcgc gcgcgctgcc cggcgtccag cccgccccgc agcaccttga cggtgacgag
     6721 cccgccgtca ccgtcgcggc cgaggtagac cacgccctgg ccgccctcgc cgagccgtcc
     6781 gagcagccgg tagccgccga tgctgcgcgg gtcgccggag ctcagcggcc gttcgtgccg
     6841 ccggcctccg ccctgccgcg ccgcgggccg cttgccggcc ccctgagcgg cctggccgga
     6901 gcgcggtttg gccggccggc catgggcctg ccccgcgcgc ccctgcccgc cacgggactg
     6961 ctgcccgttg cgtgattggg cggaacgcgc ggtgtggggg gtcgtcctcc cgcgggaggt
     7021 gtcgtgcggc aaggggggac tccgactcgg cggggacgga cgaagaattc ctcatttgta
     7081 ccttgtcacc ccggggcggg gcagcggaac cccgatcttc accccgcggt gcacgtcccg
     7141 aaggaccccg tctgctcgat gccgcgctcg gagccgccga ccatcacctt gtagcagccg
     7201 cccgcgacct tccacgcctt cgcgccctgg ttccagtacg ccagcgaccg cgaggtcagc
     7261 gggaacgtca cgcgcttgct ctggccgggg gccagctgca ccttggcgta gcccttgagc
     7321 tgccggggcg gctgcgggac gtccacgccg ggggagggca gcccgaggta cagctgcggg
     7381 acggcggtcc ccgcgcgggt gccggtgttg gtcaccgtga cctgcacgga cgtggacgac
     7441 gcggtgagcc cgccgtactt gaacgtcgtg tacgacagcc cgtacccgaa cgggtacgcg
     7501 ggcgtgaggc ccttggcgtc gtagtgccgg tagccgacca tgacgccctc ggagaacgtg
     7561 acggtcttgt tcacgccggg gaactgggcg gggttcccgg cggtgggcgc gtcgttctcg
     7621 gcggcgggga aggtgacggg gagccgcccg ccagggtcca cgtccccgta caggacgcgg
     7681 gccagcgcgt tcccgccctc ctggcccggg taccaggcct cgacgatccc cttcacctgg
     7741 ttccgccacg gggtcagcac ggccccgccg gtctgcagca cgacgatcgt gttggggttg
     7801 gccttggcga ccgtcccgat cagcgcgtcc tggtcgccgc gcagcgggtc gccgcacttg
     7861 agcgtcaggc acgagcggtc gaagaactcg ccctcgctgt cggtggcgaa cacgatcgcg
     7921 acgtcggcct tgcgggccgc gtcggccgcg gcgcccgcgt cgtcgccgtt gttgaacgtg
     7981 atcttggttc cggagcccgc gcggcgcgcg atcccgtcct gcgcgctcac ggacgcgaac
     8041 ggcacgacgt tcgccgaccc cgtcccgctc tggctctgct gcgccgcccg cccgatcagc
     8101 gcgatcgacg acggcgacct cagcggcagg atcccgcccg cgttgcgcag cagcgtgatc
     8161 ccgccctccg cgatcgtccg cgcggcggtc ccgctcgtcg tccggtcgat cgccgcgagg
     8221 tcgttcgggt acgcggcccg gtcgaacacc ccgaacgcga acatcgtccg cagcacgttg
     8281 cggacgtgcc cgtcgatcgc cgcctgcgtg accttcttct gcgcgaccgc catcttcagc
     8341 aggaacgcgt tgtacttcat gccgatcggc agttccatgt cgagcccgcc gttggcggcg
     8401 gccacggtgt cctgcacggc ggtgtggtcg gacggcacga accccttgaa gccccactcc
     8461 gaccgcagga tcccgttcag gacgccgccg tcctggcagg cccagcggcc gttcagcttc
     8521 ccgaacccgc acatgacggt ggccgcgccg ccctgcttca ccgccgcctc gaacggcggc
     8581 aggtagacct cgcgcagcgt ccgcgggtcg accttcatgt ccagcgacag ccggtcgctc
     8641 tcctgggtgt agacggccag gtgcttgacc gacgccatca cgccctgcgc ctgcgcgccg
     8701 cggatccact ccgcgccgag cccggacgac aggtacgggt cctcgccgaa gccctcgaac
     8761 gagcggccgt tgcgcggcgc gcgcagcacg tccacggtcg gcccgaagat caggtcgttg
     8821 ccgcggtgcc tggcctccca gccgaccgtc ccgccgtaca gccgcgccgc cgccgggtcg
     8881 aacccggcgg ccagcgagat cggcgcgggc agccgcgtcg ccttgccctg ccggacgccc
     8941 gccggtccgt cggccatgta gaccggcggg atcccgagcc gtggaacgcc gttgccggtg
     9001 tcggcgtgcg cggtgtcgat gaagccgccg agcgggccgc cgagcgggtc gtccgacgcg
     9061 agcatcgcga tcttctcgtc gccggtcatc ttcgccatca gcagcgcggt ccggcggtcc
     9121 gcgccgagcg aggcgtcgca ccagggccgc tgcgccgggt cgccgcagcg ggtctgcgcg
     9181 gcgcccgccg ggacggcgcc ggagaggggc gccgcgagcg cgagcaccga caccagcgcg
     9241 gccgcggccg gcgtccagcg ctccgacctg aggcccgtcg ggttccccgt ccttcgtccg
     9301 gtgcgccgca tcagtgcccc tcctcgtcct ggacgcgcag cgcgttcagc gcgaaggcga
     9361 ccatgtggta atgcccgatg agcatcacca gctcgatcag ctcccgctcg ccgaaccggg
     9421 cggacagcgc cgcccacgtc gcgtcggtga gcgtgctgcg ctcgtccagc tcgtccgccg
     9481 ccgtcaggac catcaggtcg tcgtcggacc agccgtggtc gtccagcggc agccggagcg
     9541 ccgcgatctc ggcctcggag aggcccgcgg cgagcgcgag ccggcggtgg tgcccccact
     9601 cgtacgcgca gtcccgcagg tgcgcggtgc gcatgatcgc aagctcccgg tcgcggtcgc
     9661 cgagcaggcc cttcatcagc agcgccgtgc cgaatccgat ccacttctcg aacagcctcg
     9721 gatgccggcc gagggtggtg aagacgttca gcgggccggt cgtcgcggcc acggcccgca
     9781 gcgtgccgtc ccactccgcc tcgggcagcg gggcgaggcg cggcgcgcgc tccccgggaa
     9841 tgtctgcgca catggcgaca tttctgccac caaatggtgg gacggtgcta ccccatcagt
     9901 cccacttggc cggattgtta catttcgatc acgtgcgcca cgggcgcccg gaggcgcccg
     9961 ggacgcgccc ggggagcgcc cgggacgccg gcggaccggg tcaggtgcgc cgggcggtgg
    10021 cggcgatcgc cagctcggcg agcgcgtcgc gggcgtcctc ggcgaccggc gcgcccgcca
    10081 gcgcccggcc gacctcgtcc aggtagccgt cgatcatcgc ctcgcaggcc gcgaggccgc
    10141 cggtctcctc gatgatcgtg cgcgcctcgt ccacgccggg acggtccagc tccgggtcgc
    10201 cgagccgccg ctccagcgcc gccgcctgcg cgtccgtggc gcgttccagg gtgagcgcga
    10261 ccagcaccgt ccgcttgccc tcgcgcaggt cgtcgcccgc cggcttgccg gtctcggcgg
    10321 ggtcgccgaa cacgccgagc acgtcgtcgc gcagctggaa ggcgatgccg agcggcaggc
    10381 cgtacccggt gagcgcggcg gtcacccgcg ggtccgcgcc ggccagcgcg gcgccgaggt
    10441 gcagcggccg ctcgaccgtg tacttggcgc tcttgaactc caccacccgc agcgcggtct
    10501 cggccgtcgc cccgccgcgg gtgccctcga gcatgtcgag gtactggccg cacatgacct
    10561 cggtgcgcat caggtcgtag acggcccggc cgcggctccg ccgctcctcg tccagcccgc
    10621 acgtctcgaa catctcgctc gaccaggaca ggcacaggtc gccgagcagg atcgcggtgc
    10681 cggtgccgaa cggcccggcg gcgcccggcc agccgtgcgc ccggtgcagc gcctcgaacc
    10741 tgcggtgcac cgacggctgc ccgcgccggg tgtcgctgga gtccatcacg tcgtcgtgga
    10801 tcagcgcgct cgcctggagc agctccaggg acgccgccgc gtgcacgatc gccgggtcgt
    10861 cggtgccgcc gcccgccgcg cgccagcccc agtagcagaa cgcggggcgc agccgcttgc
    10921 cgcccgcgag cagcgcgtcc agcgccgaca gcagcggacc gaggtcgtcg ctgatggcca
    10981 gcaggccggg gcgctggcgg tcgacgaagg ccggcagggc ctcgtcgacc tgcttgcgga
    11041 tgcggctcca ggacgagtgg agcgagccgg gggatgcgat gggtcgtcct cccgcgggca
    11101 ggcttggcat gcccgtgatc gtatccagcc ggacggaaga caccggtcgg ctattgagcg
    11161 atttgtcagt ccatcctagg aaatgagggc aatacagcgg tgcagacgtg tgcaggatca
    11221 cgcgtaacgg accttggccc cggtcgcggc cgcggtgtcc gcacgggccg gagcccgcgc
    11281 ccggccccac tgtaggcttg gggaatgcga cccgtacgtc ccgaccggcc cccgaccgtc
    11341 cgcgagctgc tggcctcggg cgagcggtcg ttctccttcg agttcttccc gcccaagacc
    11401 gacaagggcg cgcggaacct gtggcgtacg atccgcgagc tggagcccct gcacccgacg
    11461 ttcgtgtcgg tcacctacgg ggcgggcggc ggcacccgcg acaccaccgt cgacatcgtc
    11521 gagcgcatcg ccaccgacac caccctcacc ccggtcgcgc acttcaccgc cgtgaaccac
    11581 tcccaggccg agctgcgcaa cctgatcggc cggttcgccg ccgccggcgt ccgcaacgtg
    11641 ctcgcgctgc gcggcgaccc gcccggcgac ccgatggggg agtgggtcaa gcaccccgag
    11701 ggcgtcgagt acgccgccga gctcgtccgc atgatccgct cctacggcga cttcagcgtc
    11761 ggcgtggccg cgttcccgta caagcacccg cgctcgcccg acgtcgagag cgacacccgg
    11821 tacttcgtcg agaagtgccg cgccggcgcc gactacgcga tcacgcagat gttcttccgc
    11881 gccgaggact acctgcggct ccgcgaccgg gtcgccgcca ccggctgcgc gacgccgatc
    11941 atccccggga tcatgccggt caccaagtac agcaccatcg agcggtccga gcagctgtcg
    12001 ggcgcgccgt tcccgcccga ggtcagggcc cgcttcgacg ccgtcgccga cgaccccgac
    12061 gcggtgcgcc ggctcggcat cgagcacgcc gccgagctgt gccgcgacct gctcgacgag
    12121 ggcgcgcccg gcatccactt catcaccttc aaccagtcga ccgcgacgcg cgaggtctac
    12181 gggctgctgg agtccggcgg gtacggcgcc aagggcagcg tcccgcccat gaccgcgtag
    12241 cgggggccgc cgccggggaa ctcgaagtcg ctcagcaggt cgaccatccc gacggagcgg
    12301 tacaggtgcc gggccggcgt ctcgggccgc ttgtccagcg tcgacagcac gaccgtccgc
    12361 tccgggcggc cctcgcacag cgacgtcagc agggcgcgcc cgagccccct gccctgcgcc
    12421 tgcgggtgca cgtgcagctc cgcgacctcg aacgagtcgt ccatccacgt cgcggcgtgc
    12481 tcctcgccgc cgaggtcggc gagcgcctgg tacaccacgt cgtgccacca ctgcccgcgc
    12541 gcgccgcgga acccgtaggc gaacccgtgg accggccccg gcaggccggg cagcgcgccg
    12601 cgccgctccg cgacgaacgc gcggaacgac gggtaggcgg cgtgccgctc catgatggtg
    12661 tgccggcccg gcagctgctc gtccggcggc tccatcgcgg cccggtacac ctccagcatg
    12721 gggttgagcc ggcgtaggaa ggcgcgttcg tcgatctcgc gcagcttcgg gtccctcacc
    12781 cgacagagac tagacccgcg aggtggtccg ctgcgtggac gacagacggt cgtagatgtc
    12841 ccagaggatc cggtcggccg ccttctgcag cgccccgcgc tggccgtcga gctgcccgcc
    12901 ccacgcgcgc gcctccgggc cgagccacgc gtcggtcgac ccgagcgtcc tcaccggcgc
    12961 gtccagggcc cgccggacgc cgtcgatgct gccgtaggcg tcggcgtacg cgtggtagag
    13021 ccgctcgtac tcggggttcg gctgctcccc gggcggcagc tgcgcggccc cggcggcggt
    13081 gtacggcggg ggcaggctcc ccggaggcgg cggagcggcc atggcgacct cacatcaggc
    13141 gacggtgctc ggtgtgctct tcgggatgct cgtggggtgc tgcggggtgc tcgtggggtg
    13201 ctgctgggta ccggcagggt ggtgcggggc ggcctgcccg tcgggcgggg cggcttcggc
    13261 gtgcaccgtg ccgtccagat gcagccgggc gacggcctcg cgggtccggg cgctcaggtc
    13321 ggcctcggtg acgacccgca ccgcggaggg acgcaccccg gcccggtcgg cctccgccag
    13381 gaacgcccgc agccacttca cgtcgatcgt caggtggcgg ctcgacgtgc cgagcgactc
    13441 ctggatcacc ttcagccgcg ccgcgtcgcc gtgcgccgcg ccgaccaggc cggcggcgcc
    13501 ctccggcccg agccgcgcgt acagcgtctc ggtgtagtcg gggtcgccgg cgtcggcctt
    13561 caaccgcttc cacaccgcgt ccgggacggc cttgccgccg cggacggcgg cggcgacggc
    13621 cagcgcgtcc gcgcgggccg ccttctgcgc cgccggacgg tccggatacc cgccgaggtc
    13681 gccggcgccg tgcggcgtcg gcgcgacctt gtgcaccggg gacgtccggc ccggcgggcg
    13741 caccggacgg ggcgtcccgc ccggcgtccc gccggtccgc ttcggggccg gcgcgggcct
    13801 cggcacgggc ggggcgtcca ccccgccgcc gggatcgggg tgggagaccg cgaagttgta
    13861 ccgccgctcg agcatcccca gctggccgga cacccagtgc gccacctggt cggcctgccg
    13921 gtacccggcc tgcgacaccc cggccggcgg gcggtgcccg ttcagccagc cggagatcgc
    13981 ggcctgcgcg tcgcgcagct gcttgatcac ctgggcgagc gcgggcgggt cgatgccccg
    14041 gaagtccggg tcgcgcgcgg ccgggccggt gcgcatctgc gccgtcatcg cccctcccgg
    14101 acgtcaccca tcgtcggcgt ggaacgccgc agcgttccga tccccagaat cacacccgca
    14161 tcagcggctg tcgagggcct tcttgacgga gtcggggtcg cgcgcgacca cggcctcccc
    14221 gccggtcagc acgatcggcc gctggatcag caccgggttc gccaccatga cctcgatcca
    14281 tcgggcccgg tcgtgctcga ggtccttcag gccgagctcc ttggcgaccg gctcgttcag
    14341 gcgcgccacg tcccacggct ccgcgccgat gcgggtcagc accgcgtcca gctcctcggc
    14401 cgtcggcggc tcgtccaggt agcgccgctc ggtgtactcc acgcccgcct cgtccagcgc
    14461 ggccttggcg gcgcggctct tcgagcagcg ggggttgtgc cagatctcca tgttcggccc
    14521 tctcagccca cctcggcggg gtcgccgccg gtcatcctca gcagttccgc gtaggaggtc
    14581 gggaagacgg tgtgcggatg cccgcccgcc gcccagacct cctcgtactt gtccagccac
    14641 acgtccacca gcgtgcggat cggggccggg tgcccgacgg gcgcgacgcc gccgatcggc
    14701 tgcccggtcg ccgcccggac gaactcgggc gtcgcccgct tcaccttctc cgccccgacc
    14761 agcagcgcga ccttgccggt gtcgacccgg tgcgcgccgc tcgtcatcac cagcagcggc
    14821 gccccgtcgg cgtcgaacac caggctgttg gcgatcgcgc cgacctcgca gccgagctgg
    14881 tccgcggccg cctgcgcggt gcgggccgag tcggggagct cgacgatctc tccggccgcg
    14941 ccgtgcccgc gcagcgccgc ggcgacccgt tcgacattgg gatgcatgcc tgcaccctac
    15001 ggtgccgggc gccgtccgga cccgccgttc gcctgcgcgg acgcctccgg cctgcggaag
    15061 gcgacacccg ttcgaacacg ttgacgaatc gacggcgggg cgctttactg tgagtgcgtc
    15121 gaacttatgt tcgatgtggt gcgggactcg cggcccgcgc cagggcgacg tccccgaccg
    15181 gcgcagcggt ggccggcggg acggacggcc gggcggagtg aggggaagct ctccgcccgg
    15241 ccggcccgag ccccggaagg aggcagtcat gtccgcaacg atggccgcgc gcggagtcca
    15301 ctccgccgcc cagcccgcgc cgggcccgcg ccaccgcgcg ctgcccgcgc cccgcccggt
    15361 gcacacggcg gtcggccagc tgcacgccgc ccgcatgggc ctcgccgagg cggccgaggc
    15421 cacctcgccc gccgtccgct acgtctgcgc gcacctcgcc gcgctgcgcg ccgccgccgc
    15481 ggtgctggcg tccaaggagc ccctggagac gcaccgccgc ggccgtccgc gcagcgtctg
    15541 ggtgctgctg ccggaggccg agcccgcgct gcgcgagtgg gccgcgttct tcgccgccgg
    15601 cgccgacaag cgcgccgccg ccgaggccgg cctgccccgc gccgtcaccc cgcgcgaggc
    15661 cgaggagctc ctgcacgacg ccgaggtctt cgtcaccctc gtcgaggaca ccctcggcgt
    15721 cacgagccag cccacgttgc cgacgccctg acccgagacc ccctcgaagg gccgcccgac
    15781 cctccccagg gcccggccct gccgccggcc gggccgccgt ccgccgtcct cacgagggcg
    15841 gtggcccggc ccgcggcgct cccgcccccg gacgaccgcg tcggcgccgg ccgcgtatcc
    15901 ccccgagccg gccgggccgg cgcggtcccg ccgtcggggc gtctcggtgg gccgcgggag
    15961 ggcaccggca tactccgtgg gatggagaat gacgcgacgc cgccgctcgc ggggctgcgg
    16021 gtggtcgagc tgtccagctt cgtcgcctcg ccgctcggcg ggatgtccct cgcccagctc
    16081 ggcgcggacg tgatccgcgt cgaccagatc ggcggcggcc ccgacatcga ccggtggccg
    16141 ctcgccccgt ccggccgcag tctgtactgg gccgggctca acaagggcaa gcggtcgttc
    16201 accgcggacc tgcgctcggc cgagggccgc gcgctcgtcg cgcggctggc ggccgatgcc
    16261 ggcgtggtgc tgacgaacgc gccaccgcgc gacgggctga cgtacgaggc gctgcgcgag
    16321 ctgcggcccg acctgatcca cgtgcagctg ctcggtaccc gggagggcgg caacgccgtg
    16381 gactacacgg tgaacgccgc ggtgggcttc ccgtcgctca ccgggccggc cgcgagcgcc
    16441 gagccgtcca accacgtcat gcccgcctgg gacgtggcct gcgggctgta cctcgcgatc
    16501 gggctgctgg cggccgagcg gcaccggctg cgcaccgggg aggggacgcg gctgcgggtc
    16561 gcgctgtccg acgtcgcgct cgccaccgcc gggaacctcg ggatgctcgc cgaggcgcag
    16621 ctcgggcagg tccggccgcg gctcggcaac cacctgttcg gcgacttcgg ccgcgacttc
    16681 gccaccgccg acgggcgcgt catggtcgcg gtcctcaccg cccgccactg gcgcgacctg
    16741 gtcgccgcca ccggcctcac cgaggtcgcg gacgccctgg agcgcgcgct cggcgccgac
    16801 ttccgcaccg cgggcgaccg ctacgcctac cgggacgccc tcggcggcgt cctcgcgccg
    16861 tggttcgcgt cccggacgtg cgccgaggtc gaggacgggc tgaagggcac ctccgtgctg
    16921 tgctcccggt accgggagct cgccgaggtc gccgccggcc tgcacgacga gccgctcatg
    16981 ggcgagatcg accagccggg catcggccgc cacctggccc cggcgtcccc gatgcggctc
    17041 ggcgacgcgg tccccgcgcc ggcgcccgcg ccggagctcg ggcaggacac cggcgagatc
    17101 ctccgcgacg tgctgggcgt cccggacgag gaggcggcgg acctgcgcgc ccgcggcgtc
    17161 gcgggcgagc ccggctgagc gggccgtcac gcggcggcgc cggggccgga cgcacggcga
    17221 tcaagggttt gcggcgagcg ccggggtgga aatccttctg acagttcgac cggaatgtgg
    17281 ttttcgcccc tcgttcgtgt cagaagggac cccccgatgg cgatcgacgc cggcctggaa
    17341 cagtccgcga ccgcaccgat ccggcacccg ctggacagcg acgccgaggg cgtcaaccgt
    17401 cccggcctgc acaagaacgc ccggtaccac gagatacgcg agaccggcac cggcgtcgcc
    17461 gaggtgaccc ggcacgacgg gacggtggcc aagctcgtca cccgctacca cgacgtcgag
    17521 caggtgctgc gcaaccagga ggtgttctcc cgggaggccg cgctcgacgc cgacgccgtg
    17581 gacctcgagg ggacgatgct cggcctcgac ctggacgacc acgcggccgt ccggggcgcc
    17641 gtcaaggact ggttctcgcc gcaggcggtc gagcggctgc gggcggtcgc gggggagcgg
    17701 gcggccgagg cgctcgcggc gatgcgcggc gcgggcgagc cggccgacct cgtcaccgcc
    17761 ttcgcgctgc cgttctcgct ggacctgatc tgcgacatga tgggcctgcc gcgcgaggac
    17821 cggctgcgct tccacggctg gggcgacgcg ttcctcggca cgagcgagca gacccgcgtc
    17881 aacgcggagg agtcgcaggt cgcgatggtg acctacctcg ccggcctggt cgccgagcgg
    17941 ggcggcggca cggccgacga cctgctcacc cacatcgccg cgggggcggc cgggctgtcc
    18001 ttcgaccggc aggtcaagct gccgatgacg ctcgtcctcg gcgggtggga gaccgtggcc
    18061 agcagcatcg gcacgcaggt ccacgtgctg ctcacccacc cctacgaggg ccacgagacg
    18121 gcctacgcct acctcaccgc gcaccccgag gccgtgccgg gggccgtcac cgagatggag
    18181 cggctgttct ccacgaccgc ggccgacgac ctgccccggc gggtcacccg cgaggtgacg
    18241 ctgccgagcg gcgcccggct ggagccgggc gagctggtga tcccgtccca cgacgcggcg
    18301 aactgcgacc cccgcgtgtt cgacgacccg caccgcatgg acttcgcgcg cacgccgaac
    18361 cggcacctgt cgttcgggta cgggccgcac cactgcatcg ggcgccatct cgggcacatg
    18421 gaggtggtga cggcggtcgc gctgctcacc cgggaactgc cgtcgctgcg cctggcggtg
    18481 ccgtcggagg agatccagcg caagcccggg cacgtcatca acgggccgtc ggcgcttccg
    18541 gtggcctgga gtcccgcctg agtatgaccc gctttgtcct tactttgccc gcccgtgaga
    18601 tcgttagggc ggcgaagtaa gggagggtgc gtgacggcgc ggggcggacg agggctggtg
    18661 ccgctgctgg cgttcctcgg catgatggcg tactcgctgt cgatggcggt cgtgacgccg
    18721 gcgctcgcgc tgatccagca gggcctgcac accacggcgg ccggcgccgc gtgggcgatc
    18781 acggcgatga cgctgtcggc cgccgtggcg acgccggtgg tcggccgtct gggcgacctg
    18841 tacgggccgc gccgggtgct gctcgccgtg ctggcgatcg ccaccgtcgg catggtcatc
    18901 gccgcggcgg cggggtcgct cccgctgatg ctggtcggcc ggatgctgag cgggatcggc
    18961 ggcggcgtct tcccgctcgc ctacacgatc atccgggacg tctacccgcc cgcccggacg
    19021 gcgtccgcgg tcggcctgat gtcgtcgatg ctcgggctcg gcggggcggt gtcgtggtgc
    19081 ctggccgggc cgatcatcga cctgctgggc tggcgctggc tgctctgggt gccggtggcc
    19141 gggctcgtgc cgggcgtcct gctcgcctgg tggatcgttc cagcgtcccc gccccgggag
    19201 gccgccaagg tcgactggtg gggcgccgcg ctgttcggcg gctggctcgt cgcggcgctg
    19261 accgcgctca ccgaggggat ggactggggc tggacgtccc cgggcgtcct cggcctgctc
    19321 ggcctcgcgg cgctcctggc cctggtgtgg ctgcgggtcg aggcccgcgt cgccgaaccc
    19381 ctcgtcgacc tgcggctgat gcgggtgcgc ggggtctgga cggcgaacgc cgcgtccctg
    19441 ctgtccggct acgcgctgat ggccggcggc ctgctgttcc cgctgctcgt ccagctcccc
    19501 gcgagcaccg gctacggctt cggtgggacg gccacccagg cggccctgct gcagctgccc
    19561 gccagcatcg ggatgacggc cgcggggatg accgcggggc tcctcgaccg ccggatcggg
    19621 tcgcgcctgg tcctgctcgg cggggccgtg ctgaccgccg ccggctacgc cttcgtggtc
    19681 gtcgagcacg cggcgatgtg gcagctctac gtcggcggcc tcggccgcgg catcggcctc
    19741 gggttcgcct acgccgccgt cgcgaacctc gtcgtcgcgg ccgtcccggc gggggagacg
    19801 ggcgtcgcca ccggcatcaa caccctcatc cgcaccgtcg gcgcgtccct cggcacgcag
    19861 gtcagcgccg tgatcgtggc gggccttccg ggggagcgcg gcttctccgc cgggttcgcg
    19921 gtcagctccg ccgtcatggt cgcggtgctg ccgctcgccc tgctcgtccc gccccgggcc
    19981 cgccgctccg ggaagggcgc gccctgccga ggcgaggagc gcagtgccgc ccccgtcaca
    20041 tgaggtccgc cggtggacgc agagtgatgg gcggcgcgcg ggtacacgga acggggcccg
    20101 gctgccgcca ggccccgtct cgtcatgcgg tcggtcagaa cgactcgacg gcgcggcgcg
    20161 cctccgggtc gagcaccccc caggtgatga gctcctcggt cagctcggtc ggggacttgt
    20221 catagatgac cgccagggac cgcaggtctt cctggcggat ggacaggacc tttccgttgt
    20281 agtcgccccg ctggctctgg atcgtcgcgg cgtagcgggc gagaggaccg gccttgtcct
    20341 tcggaagctg ctgcaggcgc tcaaggtcga tgacgagctt gggcgtgggc ccgagcgggc
    20401 tcggcgcggc tccgccgggc agcaactcgg aaaccggcac gccgtagaaa tcggcgagct
    20461 cggccagctt ctgaacggtg acggcgcggt cgccccgctc gtacgaaccc acgacgacgg
    20521 ccttccagcg gccgcgggac ttctcctcca caccgtgcag cgacagcccc tgctgcgtgc
    20581 ggatggcgcg caggcgcgcg ccgagagcct ttgcgtattc agacggcatt ctgcggcccc
    20641 ccaggctcac ttcgtcgtcg ttggaccccg gcgggcgccg gggggagaca gattcccgga
    20701 gccatggggc cccaagaccc tgtccccagg gatggttacg gacagtgacg gtaaaacggt
    20761 gagggcccta ggtcaagctg attggaaaaa agcggtcgaa tccgcaggtc tcgatccggg
    20821 ccgtccggat ccccgcgacc cccggcgggc agggcggcgc gggtcgccgc gggccgtccg
    20881 gcgaccccgc gtgaaggccg agtgtgaccc ctctcaccag gcaagacgcg ggagggccgg
    20941 gtgcggggca gtcgcgcccg gctgctaccg tgtccgggac aagacgtcct ttaagacccg
    21001 tcccgtgagg cgggaaagga ggtttcggtg gtgaatgctg cctccaggcc ggaacggcct
    21061 gcgggggcgc gcgcggagac cgacccccgg cccaaggccg ttctggaggg
//
