LOCUS       NZ_CP053892            21011 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8910350
            Orig. end                         :: 8931361
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..21011
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="24"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21011
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21011
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11011](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11011)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    383..397
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     misc_feature    584..595
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.47"
                     /tool="antismash"
     gene            747..2312
                     /locus_tag="ACTIVE_RS40130"
                     /old_locus_tag="ACTIVE_8052"
     CDS             747..2312
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017588816.1"
                     /locus_tag="ACTIVE_RS40130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8052"
                     /product="MFS transporter"
                     /protein_id="WP_246342472.1"
                     /transl_table=11
                     /translation="MDSQTVQRRRWYILGVLTVSLLVVVLDNTILNVALKTIADPDKGL
                     GATQSQLEWAINSYTLVFAGLLFTFGVLGDRLGRKRVLMGGMAVFALASLVSAYAQSPD
                     QLIYARALMGLGGAAIMPQTLSIITNVFEPHERARAIGIWAGAVGLGVAIGPLTGGLLL
                     AHFWWGSVFLINVPVIAAGVALMAFLVPESRNPNPGRLDPLGVLLSVAGLVVLSYGIIQ
                     GGDKGEWLTTGTLGPILAGAAVLALFVWHEARTASPAFDVRLFKDARMSAAVASIALCF
                     FAATGVFFFANFYMQSVRGLTPLQSGLMVLPFAAAQLIFSPRSASLVRRFGAKAVCTSG
                     LLAVTVALIGYQFVGTTTPLWVLGAVFFVQGAGMANVMPPATESVMSALPREKAGAGSA
                     VNNVARQVAVAMGVAVLGSVVASVYRGELHDRLAALPAGAREAAGESIEGAHAVAARMG
                     AAGHGLIGPADTAFVHAMHAASIAAAVVSFLGAMVVLKWMPGRAAAVPAAENQAAPEPE
                     KAGV"
     gene            2328..2918
                     /locus_tag="ACTIVE_RS40135"
                     /old_locus_tag="ACTIVE_8053"
     CDS             2328..2918
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547732.1"
                     /locus_tag="ACTIVE_RS40135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8053"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_173099850.1"
                     /transl_table=11
                     /translation="MNDTTTNRAPGRPRSERAEKAIIEATLDLLAAESGVAAVSIEAVA
                     ARAGVGKTTIYRRWPSKEALIVGALGAAKGELPRPSGASVREDLLEIARTFAAERKKRY
                     SRCFWNVVGGAEKHPELYARYKQDVIEPRRAVIREVLRRGVETGELRADLDIEAGISML
                     TGSLSTKTPQETLPEGYAETVVDLLLTGIGAPS"
     misc_feature    2999..3019
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            3112..5217
                     /locus_tag="ACTIVE_RS40140"
                     /old_locus_tag="ACTIVE_8054"
     CDS             3112..5217
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630926.1"
                     /locus_tag="ACTIVE_RS40140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8054"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_173099851.1"
                     /transl_table=11
                     /translation="MAPRGDAPATDSASRTLVLGVDGARRIVQCGPNSAAVIGRAPQDL
                     IGRPAADLVADEAKAELETLLEALAAGQERTAVLAVPRGDGGPSPDAVVTAQPMLGGDA
                     GTGPAGLLYVRVPLPPSERYQDPALMRRALMDDQLTRFGASLDLDQSARGLVDVVVPHY
                     CNAASVLVLESLVAADEVHSESGAAVLRRIAVTSDDGNPAWGATFPVGEVLVFPEGTPY
                     RQVMETAQPVHLPHIDAAAAGDIGAKWRRNPAGDLLSGVSMVLLPMIARDTLLGFIACT
                     RIPGFRKFDAYDVEIGMEFAARAAIVIDNARQFSRERSTALALQRSLLPLRLSAPSSVE
                     VRHRYLPGSKLVEVGGDWYESIALPGARVALIVGDVAGHGVRAAVTMGRLRTALHTLAN
                     LELPPADALHVMHELMIELGEQEPHFATCVYAVYDATTGTIEIASAGHLPPLLAAPTGD
                     NEYLTVPPAPPLGVAGGAAIESREFTVEDGSLFVIYTDGLVENRGRDIDDGLARLKGIF
                     GPGAVDRPMEDLAKATLAGVYADQHRDDIAVLIARLRRIPEDRFVSWTLPADPAAVRRA
                     RGLVRTRLEEWGLDELDYTTELLASELITNALRYAPGPIELRLLFERTLVCEVLDRSAA
                     LPRLRRAEDDDENGRGLLVVSQLAHRWGTRRTAAGKVVWCEQIVPGIDPDPVDLDSAWP
                     GESHHRE"
     gene            complement(5412..7196)
                     /locus_tag="ACTIVE_RS40145"
                     /old_locus_tag="ACTIVE_8055"
     CDS             complement(5412..7196)
                     /EC_number="6.3.5.1"
                     /GO_function="GO:0003952 - NAD+ synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630925.1"
                     /locus_tag="ACTIVE_RS40145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8055"
                     /product="NAD+ synthase"
                     /protein_id="WP_173099852.1"
                     /transl_table=11
                     /translation="MAQLRIALAQVNPTVGDLDGNAGLIVEWAARAAAAGAHLAAFPEM
                     MLTGYPVEDLALRGSFVEASRHALERVAARLADEGLGDLPVVTGHLDRPPVGLVRAGQP
                     SGLPLNAAAWLHRGEVLVRSAKHHLPNYGVFDEYRVFVRGDRLPVVRVHGVDVATAICE
                     DLWQDGGPVGVAGEAGAGLLLVLNASPYERDKDDVRLDLCAARAREAGCALAYVNMVGG
                     QDELVFDGDSIIVGADGSLLARAPQFVEHLLVADLALPAAGPTAEPGRTPVDAHDGTTI
                     TLDRIVLSPRPVPAYPVAPQTVAAPLDDLAEIYAALVLGTRDYVRKNGFRSVILGLSGG
                     IDSALVATIASDALGPENVHAVLLPSRYSSEGSVTDAEDLVKRQGINARIVPIADMVDA
                     FEDELDLHGLAAENLQARIRANVWMGLSNEHGHLVLTGGNKSELATGYSTLYGDSAGGF
                     APIKDVFKSTVWDLARWRDAQAGVDLPFLHPFAQEPIPQAIIDKEPSAELRPGQRDIDS
                     LPDYAVLDPLLADYVERDLGRDALVAAGHDPALADRVIRLVDLAEYKRRQYPPGPKITP
                     KNFGRDRRLPITNRWQEH"
     misc_feature    7224..7244
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.8"
                     /tool="antismash"
     gene            complement(7233..8492)
                     /locus_tag="ACTIVE_RS40150"
                     /old_locus_tag="ACTIVE_8056"
     CDS             complement(7233..8492)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630924.1"
                     /locus_tag="ACTIVE_RS40150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8056"
                     /product="MFS transporter"
                     /protein_id="WP_246342473.1"
                     /transl_table=11
                     /translation="MTTLDDTPVGPPAGRIATFLRPRVGGLPRTFWVLWAGTLLNRLGT
                     MVEPFLGLYLTTARGLSLGQAGAVMAVLGAGSFAGQIAGGALADRIGRRATLTTATVGT
                     GAAMLALGYAHGIAMITVAALVLGLLLDMYRPASQAMVADIISPAERPRAFGLLFWAVN
                     LGWAFSMVLGGTLAREGFQLLFWIDALTCAAFGVLVWRAVPETRVRGGGREDGPGGFVQ
                     VLRDRVMVGYAAVMLCYTFVLMQGMTTMPLAMKEAGLGPQDYGIAIAANGALIIIVQPL
                     VNAWLSRRDHSLVMVAGFVLVGAGYGLTALVSSLPGFTATILVWTLGEITAASVLQAVV
                     ADLAPPHLRGRYSGLYGMAWSGGFLLAPLGGTQLLGTGGPALLWLSCTGLALAAAAGQL
                     ALAPAVRRRRAAVIDDSFSS"
     misc_feature    8530..8550
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.49"
                     /tool="antismash"
     gene            8565..9569
                     /locus_tag="ACTIVE_RS40155"
                     /old_locus_tag="ACTIVE_8057"
     CDS             8565..9569
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630923.1"
                     /locus_tag="ACTIVE_RS40155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8057"
                     /product="DUF5937 family protein"
                     /protein_id="WP_173099853.1"
                     /transl_table=11
                     /translation="MIEFVFAPDDAARVRFAFSPLWEMVRSLRVLTDPSGRALHLPWVH
                     GVRPRLRGLGVEPLLAVVPSTGYIPDFLTPPPETPLPDLGAELETVRNTPPEVVADELS
                     WTEPGRRADPARLALAADPERTLETLADLLERYWAAAVEPYWPRLRDLLEGDVLRRTRA
                     LAAHGIAGVFGDLHDDVRWRSGTLMIDRRWDFRGELLGRGLLLVPSAFVWPHVSVMVPP
                     YQPMLSYPPNGVGTLWETGRDRGAGPGALAALIGRRRAELLTALATPASTTELAARMGV
                     TAGAVSQHLGVLRACGLVTGHRLGRRVLYARTPTGDTLATSTGNGRRRSPDRP"
     misc_feature    8569..8584
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            complement(10001..11011)
                     /locus_tag="ACTIVE_RS40160"
                     /old_locus_tag="ACTIVE_8058"
     CDS             complement(10001..11011)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654913.1"
                     /locus_tag="ACTIVE_RS40160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8058"
                     /product="terpene synthase family protein"
                     /protein_id="WP_246342474.1"
                     /sec_met_domain="T1TS (E-value: 3.5e-48, bitscore: 164.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRAAALASPSAMHPESWQLGAQVEAWARGRGLVLGDPDTSPLG
                     RARCERLAARVFPDAELASVDLFARWLTWALALDDTLDHPPLADSGSAVHALYDDLLRA
                     MRRGHARPGARPLESALVELWQATSKGMSRDWRRRFILQLEAHRDGCAEEAVNRRIRHV
                     PTPPEFAALRRRACGPFLYDLVEPVLGVELPARLLRTPRWLTVAESVADVVAWSNDLAS
                     HEMESARGDVHGLPAVLAAAHHLAPEQAAELVADRIAARLEQAWKAARRLPEMLDRLQL
                     TVAQRAAAAQVVKVLLDTPRAHMDWLAESGRYESAAPAQLRLNALSDCRILGVGR"
     misc_feature    complement(11048..11063)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.07"
                     /tool="antismash"
     gene            11195..12013
                     /locus_tag="ACTIVE_RS40165"
                     /old_locus_tag="ACTIVE_8059"
     CDS             11195..12013
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630921.1"
                     /locus_tag="ACTIVE_RS40165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8059"
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="WP_246342475.1"
                     /transl_table=11
                     /translation="MSRRTMRWALCAGVAALALTASACGGSDGATVQGVKLIKKGALTS
                     CTHLPYPPFQVEQGGKVVGFDVDMIDLVAKKLGVTQKVVDTPFETMKTGAALNAGKCDI
                     VMGGMTIKPDRVKFMDVSEPYFDATQSLMAKKGSGITSLEDVKAKKLKLGSQASTTGED
                     FVKGKGFDPSSFDNSNAELDGLRTGQVDVIVQDDPVVKGWLKDPANSKYEIVANLNTGE
                     QYGFWIRKDYNKKLVELTNQAIQQAKQDGTYKKIYEKWIGPMPAAAGKPS"
     gene            12010..12843
                     /locus_tag="ACTIVE_RS40170"
                     /old_locus_tag="ACTIVE_8060"
     CDS             12010..12843
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654911.1"
                     /locus_tag="ACTIVE_RS40170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8060"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_173099855.1"
                     /transl_table=11
                     /translation="MTTEQVTPVAAPGGLSRRARRRLSLGGQYGLFIVIVVLVASLANW
                     PQLHTNFANWQVAKGLFPEIITVGLRNTATYTAVGFGIGLVLGLVVALMRLSPVLPYRW
                     FATAYIEMFRGLPLLLIFIFVGVGVPLAFPGTNIPGGAVGQAGLALGLAAAAYMAETIR
                     AGIEAVPKGQLEAARSLGMSQGRSMRSIILPQAFRIIIPPLTNELVLLCKDSSLVLFLG
                     ITLEQRELTKFGRDLAGQQGNTTPIIVAGICYLIITIPLSLLARRLEARQRREQR"
     gene            12849..13679
                     /locus_tag="ACTIVE_RS40175"
                     /old_locus_tag="ACTIVE_8061"
     CDS             12849..13679
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654910.1"
                     /locus_tag="ACTIVE_RS40175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8061"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_173101746.1"
                     /transl_table=11
                     /translation="MEKDAGRAGGTGRAVEISGLHKSFGSNEVLRGIDFHVERGEVVCV
                     IGPSGSGKSTLLRCVNLLEEPTAGTVRVAGAEITDPDVDIDAVRRRIGMVFQSFNLFPH
                     LTALGNVTIAQRKVLKRDKAEAERIARENLERVGLADKVDAYPGKLSGGQQQRVAIARA
                     LAMGPEVMLFDEPTSALDPELVGDVLGVMRGLAEAGMTMLVVTHEMSFAREVADRVVFM
                     DGGVVVEEGPPARVISAPEHERTRAFLSRVLDPAAARVEGSGPSDKFGSDEANA"
     gene            13760..15121
                     /gene="glnA"
                     /locus_tag="ACTIVE_RS40180"
                     /old_locus_tag="ACTIVE_8062"
     CDS             13760..15121
                     /EC_number="6.3.1.2"
                     /GO_function="GO:0004356 - glutamine synthetase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glnA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686332.1"
                     /locus_tag="ACTIVE_RS40180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8062"
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="WP_173099856.1"
                     /transl_table=11
                     /translation="MDRQQEFVLRTLEERDIRFIRLWFTDVLGFLKSVAVAPAELEGAF
                     GEGIGFDGSAIEGFARVYEADMIAKPDPSTFQVLPWRSESPGVGRMFCDILMPDGAPSF
                     ADPRYVLKRALARAADLGFTFYTHPEIEFFLLNDKPEDGSEPEPADAGGYFDHTPHSAA
                     HDFRRNAIMMLEAMGISVEFSHHEGAPGQQEIDLRYADALTTADNIMTFRLVMKEVALD
                     QGVHATFMPKPFTEHPGSGMHTHMSLFEGDRNAFFEPGAEYKLSKVGRAFIAGLLRHSA
                     EITAVCNQWVNSYKRLWGNVGSAAGAGGEAPSYICWGHNNRSALVRVPMYKPHKGHSTR
                     IEFRSLDTAANPYLAFAAILGAGLKGIEEGYELPQGAEDDVWALTPAERRALGIEPLPQ
                     NLDEAVHAMERSELMADVLGEHVFDFFLRNKRQEWEDYRRQVTEFERKRLLAVL"
     gene            15141..18191
                     /locus_tag="ACTIVE_RS40185"
                     /old_locus_tag="ACTIVE_8063"
     CDS             15141..18191
                     /EC_number="2.7.7.42"
                     /EC_number="2.7.7.89"
                     /GO_function="GO:0008882 - [glutamate-ammonia-ligase]
                     adenylyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853431.1"
                     /locus_tag="ACTIVE_RS40185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8063"
                     /product="bifunctional [glutamine synthetase]
                     adenylyltransferase/[glutamine
                     synthetase]-adenylyl-L-tyrosine phosphorylase"
                     /protein_id="WP_246342476.1"
                     /transl_table=11
                     /translation="MSEPWTSDRRRPSLAGRLARLGFTDAGRAERLLAEAERDAGAAIG
                     DDLLDALGGTADPDLALNGLLRVLASAAERGVADELRAALHREPGTRERIAAVLGVSDA
                     LADHLVRHPEHWRVLRDDGAPGEPGRPSAAALRTGLLEAVGADPSAEDPVASGAGTEAL
                     VALRAAYRARVLSLAGRDLIGVADVAEVAAELADLAAAALEAGLAIARAEVDGHAACRL
                     AVIGMGKCGGRELNYVSDVDVIFVAEAREGVDEDAALRTATRLASAMMRACSASTEEGA
                     LWEVDAALRPEGKAGPLVRTLASHRAYYERWAKTWEFQALLKARPIAGDPGLGARYMDA
                     ITPIVWKAAEGESFVQDVQDMRRRVEKDLDRRTGDSERQLKLGPGGLRDVEFAVQLLQL
                     VHGRADATLRSPGTLDALAELSQGGYVGRDDAAALASAYRFLRRVEHLIQLHHLRRTHL
                     VPDDAADLRRLGRALGLRTDPVGEFTALWRRHAREVRRIHEKLFYRPLLRAVARLPGEE
                     ARLTPEAARTRLEALGYADPAGALRHIEALTSGVSRRAAIQRTLLPVMLGWFADAPDPD
                     AGLLGFRKVSDALGTTPWYLRLLRDEVSVAERMACLLGSSRYATDLLLRAPEAVALLVG
                     ADGLRPRPHEALRAEMLAAVRRHAEGGGPAEEAVAVVRGLRRRELFRVSAADLLGLADV
                     ETVGAALTDIAAVTIEAALRAAVSKIEMEAREPLPTRMAVVAMGRFGGHELGYGSDADV
                     MFVHDPCPGADERAAGRAAHAVAEELRRLLALPAPDPPLDIDPNLRPEGRQGPLVRTLA
                     SYAAYYRRWSQPWEAQALLRADPVIGDPGLCERFRALIDPIRWPEDGVGEDALRQIRTL
                     KARMESERLPRGVDRRLHIKLGPGGLSDVEWVAQLLQLRHAHAVPALRTTRTLAALEAA
                     ADAGLLDRDDAEVLTDAWCLATRIRGSLMLVRGRASDLLPTDHHRERTAVSSVLGYPGA
                     GALLEDYQRHARRARAVVDRVFYGAED"
     gene            complement(18277..19083)
                     /locus_tag="ACTIVE_RS40190"
                     /old_locus_tag="ACTIVE_8064"
     CDS             complement(18277..19083)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630915.1"
                     /locus_tag="ACTIVE_RS40190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8064"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_246342477.1"
                     /transl_table=11
                     /translation="MLTAPPVWRELLLLVLFYTGYTLTRIVLVQDGTGPAFTHAYQILH
                     AEKLVGLDVELGLNKTLINVPWLARTANMFYATMHFILTALVVVWLYRYRPREYRWLRT
                     GIMAATALALIGFWLYPLAPPRFLHSAGFVDPVTYLHSFGLYSSDASGSLTNQYAAMPS
                     MHAGWALWCGFVLVKFVSQRWAKVLGVIYPATTVFVILSTANHYVLDAVIGMALIGGSL
                     GVAWLLYTRCPQPVIDLRDRAVQRIRHPHGSRRPDGAAGAASGSRC"
     gene            19404..20966
                     /locus_tag="ACTIVE_RS40195"
                     /old_locus_tag="ACTIVE_8065"
     CDS             19404..20966
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (134-277). E-value:
                     7.3e-16. Score: 50.4. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS40195_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540185.1"
                     /locus_tag="ACTIVE_RS40195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_8065"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_173099858.1"
                     /sec_met_domain="PF00561 (E-value: 2.5e-25, bitscore: 88.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALIGSIPGITTASTATLAAFGLISCSGWADGPDGSAAVRAAAAV
                     TGGTVPKPVWRPCTGLPAPDQGVSQARYRCATLRVPLDHADPSSGTIGIALMKIPAKGP
                     GRRIGSLLFNFGGPGGDGVDTLAQAAPQYATLNARYDLVGFDPRGVGRSAPVTCVDDRT
                     MDQIAAEDDTPDTPAEETAYLARRASYARACEARSGRLLPHVGTLSAARDLDAIREAVG
                     DPKLNYFGISYGTWLGGNYAHQFPGGVGRAVLDGAVDTRLNTADLGLQQAAGFQRALVD
                     FGAACAKLGAKSCPLGGDGESVAAATGKILASLDRKPLKTSGGRKLTQSLGDTGAAAAL
                     YSKQAWPYLAQGLVDAVKRHDGTLLLMLADLQNGRKSSGAYANLTAANTAITCADGSDR
                     YTVADVRRLMPAFRKASPVFGPSMAWGLLQCTGWPVKGDDAAREVSAPDAAPILVVGNT
                     GDPATPYAWASALVKSLGGSAALLTLKGEGHGAYDTGDPCVRRVVDSYLLDGLLPAAGA
                     TCG"
     aSDomain        19806..20234
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS40195_Abhydrolase_1.1"
                     /evalue="7.30E-16"
                     /label="ACTIVE_RS40195_Abhydrolase_1.1"
                     /locus_tag="ACTIVE_RS40195"
                     /protein_end="277"
                     /protein_start="134"
                     /score="50.4"
                     /tool="antismash"
                     /translation="TLNARYDLVGFDPRGVGRSAPVTCVDDRTMDQIAAEDDTPDTPAE
                     ETAYLARRASYARACEARSGRLLPHVGTLSAARDLDAIREAVGDPKLNYFGISYGTWLG
                     GNYAHQFPGGVGRAVLDGAVDTRLNTADLGLQQAAGFQR"
     misc_feature    20991..21006
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.72"
                     /tool="antismash"
ORIGIN
        1 cgccgaagac gttgacggac tgcggggtga ggccgaggtg gcccatcacc gggatgccgg
       61 cggagaccat cgcctcgacc tgcggcagga tccggcggcc gccctcgacc ttgaccgcgt
      121 gcgcgccggt ctccttgagg aaccgggtgg cggcggcgag cgcctcgggg acgccggtct
      181 ggtacgagcc gaacggcagg tcggcgacga ccatcgcgcg cttggagccg cgcacgaccg
      241 cggcggcgag cgggatcagg tcgtcgaccg tgacggggat cgtcgagtcg tagccgtaca
      301 cgaccatggc ggcggagtcg ccgacgagca gcacggggat gccggcctcg tcgaagatcc
      361 gcgcggtgag ggcgtcgtag gcggtgagca tcggccactt ctcgtgccgc tccttggcgg
      421 ccgcgatgtc gcggacggtg acccttcgcc cgccggtacc gccgtagagc gcggccggct
      481 gcgcgggggg cgtcgcggaa gaggacgcag aagaagacat ggagaacctc cggtcttgag
      541 gcgccacggt ggcgtaccca gacggatccg atggtgccac ttcgaaaacg attcgggtac
      601 cccccgggat tccccgatcc gccgggcgcc ggccggaaca aattacgaaa cgctacggtt
      661 gcgtatcgaa gcagggcggc gtacgctccc tacgaaacga cacgtacccg tatcgcattc
      721 cccccgtcca cgattcaagg agcgctgtgg actcccagac cgtccagcgg cgccggtggt
      781 acatcctcgg cgtgctgacc gtgagcctgc tggtggtggt gctcgacaac accatcctca
      841 acgtcgcgct caagaccatc gccgaccccg acaagggcct cggcgccacc cagagccagc
      901 tcgaatgggc gatcaactcc tacacgctgg tcttcgccgg gctgctgttc accttcggcg
      961 tcctcggcga ccgcctcggc cgcaagcgcg tgctgatggg cggcatggcc gtgttcgccc
     1021 tcgcctcgct ggtgtcggcg tacgcccagt cgcccgacca gctcatctac gcccgcgccc
     1081 tgatgggcct cggcggcgcc gcgatcatgc cgcagacgct gtcgatcatc accaacgtgt
     1141 tcgagccgca cgagcgcgcc cgcgccatcg gcatctgggc cggcgccgtc ggcctcggcg
     1201 tcgccatcgg ccccctcacc ggcggcctgc tgctcgccca cttctggtgg ggctcggtct
     1261 tcctgatcaa cgtgccggtc atcgccgccg gcgtcgcgct gatggccttc ctcgtgcccg
     1321 agtcgcgcaa cccgaacccg ggccgcctcg acccgctcgg cgtcctgctg tcggtcgccg
     1381 gcctggtcgt gctgtcctac ggcatcatcc agggcggcga caagggcgag tggctgacca
     1441 ccggcaccct cggcccgatc ctcgccggcg ccgccgtcct cgccctgttc gtctggcacg
     1501 aggcccgcac cgcctcgccc gccttcgacg tccggctgtt caaggacgcg cgcatgtcgg
     1561 ccgccgtcgc gtccatcgcg ctgtgcttct tcgccgcgac cggcgtgttc ttcttcgcca
     1621 acttctacat gcagtcggtg cgggggctga ccccgctgca gtccggcctg atggtgctgc
     1681 cgttcgccgc ggcccagctg atcttctccc cgcgcagcgc gtcgctggtc cgccggttcg
     1741 gcgccaaggc cgtctgcacg tccgggctgc tcgcggtcac ggtcgcgctg atcggctacc
     1801 agttcgtcgg caccaccacc ccgctgtggg tgctgggcgc cgtgttcttc gtgcagggcg
     1861 ccgggatggc caacgtgatg ccgcccgcca ccgagtcggt catgtccgct ctgccgcgcg
     1921 agaaggccgg cgcgggatcg gccgtcaaca acgtcgcccg ccaggtcgcg gtcgcgatgg
     1981 gcgtcgccgt cctcggctcc gtcgtcgcgt ccgtctaccg cggcgagctg cacgaccggc
     2041 tcgccgcact gcccgccggg gcccgcgagg ccgccggcga gtccatcgag ggcgcgcacg
     2101 ccgtcgccgc ccggatgggc gccgcgggcc acggcctcat cggccccgcc gacaccgcgt
     2161 tcgtgcacgc catgcacgcc gcgtcgatcg ccgcggccgt cgtgtccttc ctcggcgcca
     2221 tggtcgtcct gaagtggatg cccggacgcg ccgccgccgt tcccgccgcg gagaaccagg
     2281 cggctccgga accggagaag gccggcgtgt gagaacgtga gcatgcgatg aacgacacga
     2341 cgaccaaccg cgcgccggga cgcccgcgca gcgagcgggc cgagaaggcc atcatcgagg
     2401 ccaccctcga cctgctcgcc gcggagtccg gggtcgccgc cgtctccatc gaggcggtgg
     2461 cggcccgggc cggcgtcggc aagacgacga tctaccggcg ctggcccagc aaggaggcgc
     2521 tgatcgtggg cgcgctcggc gcggccaagg gcgagctgcc ccggccgtcc ggcgcgtccg
     2581 tccgcgagga cctcctggag atcgcgcgga ccttcgccgc cgagcgcaag aagcgctact
     2641 cccgctgctt ctggaacgtg gtcggcggcg cggagaagca ccccgagctg tacgcccgct
     2701 acaagcagga cgtcatcgag ccgcgccgcg ccgtcatccg cgaggtgctg cgccgcggcg
     2761 tcgagaccgg ggagctgcgc gccgacctcg acatcgaggc cggcatctcg atgctgaccg
     2821 ggtcgctgtc caccaagacc ccgcaggaga ccctcccgga gggctacgcg gagaccgtcg
     2881 tggacctcct cctgaccggg atcggcgccc cgtcctgacc ggatccggcg gggcggggcg
     2941 gggccgcgga ggcccttgtc ctcgggagat atcgcccgag aacccgcata ccgcacggtt
     3001 ttcgtcgcgg taaccgtgat cttctcccgc cgatcacgtg tcatgcccca tactgtcgct
     3061 gggtagtgct aagacgaccg gctgtctgga gcgcgtcagg tgagatccgt catggcgccg
     3121 cgaggcgatg cgcccgccac cgattcggcg tcccggaccc tggtcctggg cgtggacggg
     3181 gcccggcgga tcgtccagtg cggacccaac agcgcggccg tcatcggccg cgccccgcag
     3241 gacctgatcg gccgcccggc cgccgacctc gtcgccgacg aggccaaggc cgagctggag
     3301 accctgctgg aggccctggc cgccgggcag gagcgcaccg ccgtgctcgc cgtcccgcgc
     3361 ggcgacggcg gaccgtcccc ggacgccgtc gtcaccgccc agccgatgct cggcggcgac
     3421 gccggcaccg gccccgccgg gctgctgtac gtccgggtcc cgctgccgcc cagcgagcgc
     3481 taccaggacc cggcgctcat gcgccgcgcc ctgatggacg accagctcac ccggttcggc
     3541 gcgtccctcg acctcgacca gtccgcccgc ggcctcgtcg acgtcgtcgt cccgcactac
     3601 tgcaacgccg cgtccgtgct ggtgctggag agcctcgtcg ccgccgacga ggtgcacagc
     3661 gagtccggcg cggccgtgct gcgccgcatc gccgtcacct ccgacgacgg caaccccgcc
     3721 tggggcgcca ccttccccgt cggcgaggtc ctggtgttcc ccgagggcac cccctaccgc
     3781 caggtgatgg agaccgccca gcccgtccac ctgccgcaca tcgacgccgc cgccgccggc
     3841 gacatcggcg ccaaatggcg ccgcaacccc gccggcgacc tgctcagcgg cgtgtccatg
     3901 gtgctgctgc cgatgatcgc ccgcgacacc ctgctcggct tcatcgcctg cacccgcatc
     3961 cccggcttcc gcaagttcga cgcctacgac gtcgagatcg gcatggagtt cgccgcccgc
     4021 gccgccatcg tcatcgacaa cgcccggcag ttcagccgcg agcgctccac cgccctcgcc
     4081 ctgcagcgca gcctgctgcc gctgcggctg tccgcgccgt cctcggtcga ggtccggcac
     4141 cgctacctgc ccggcagcaa gctcgtcgag gtcggcggcg actggtacga gtcgatcgcg
     4201 ctgcccggcg cccgcgtcgc cctcatcgtc ggcgacgtcg ccgggcacgg cgtccgcgcc
     4261 gccgtcacca tgggccggct gcgcaccgcg ctgcacaccc tcgccaacct ggaactgccg
     4321 cccgccgacg ccctgcacgt catgcacgag ctgatgatcg agctcggcga gcaggaaccg
     4381 cacttcgcca cctgcgtgta cgcggtctac gacgccacca ccggcaccat cgagatcgcc
     4441 tccgccgggc acctgccgcc gctgctggcc gcccccaccg gcgacaacga gtacctgacc
     4501 gtcccgcccg cgccgccgct cggcgtcgcc ggcggcgccg ccatcgagag ccgcgagttc
     4561 accgtcgagg acggcagcct cttcgtcatc tacaccgacg gcctcgtcga gaaccgcggc
     4621 cgcgacatcg acgacggcct cgcccgcctc aagggcatct tcggccccgg cgccgtcgac
     4681 cgcccgatgg aggacctcgc caaggccacc ctcgccggcg tctacgccga ccagcaccgc
     4741 gacgacatcg ccgtcctcat cgcccggctg cgccgcatcc ccgaggaccg gttcgtctcc
     4801 tggacgctgc ccgccgaccc cgccgccgtc cgccgcgccc gcggcctcgt ccgcacccgc
     4861 ctggaggaat ggggcctgga cgagctggac tacaccaccg agctcctcgc gtccgagctc
     4921 atcaccaacg cgctgcgcta cgcgcccggc ccgatcgagc tgcgcctgct gttcgagcgc
     4981 accctcgtgt gcgaggttct ggaccggtcc gcggcgctgc cccggctgcg ccgcgccgag
     5041 gacgacgacg agaacggccg cggcctcctc gtcgtcagcc agctcgcgca ccgctggggc
     5101 acccgccgca ccgccgcggg caaggtcgtc tggtgcgagc agatcgtccc cggcatcgac
     5161 cccgacccgg tcgacctcga ctccgcctgg ccaggcgaaa gccaccatcg cgaatgacaa
     5221 cgacgggcaa agcgttcccg ctccgccggc gccccctagg ggtgcccgtc cttgcccctg
     5281 ggccgcgcac gaacctcagc gttgcgatcg cgtgcgaagc cggatacgag cggagcgatg
     5341 cagcgatcgc cgcatcgccc gttgaaggga gggcccccag ggcccgaccg ccgagggcgg
     5401 tgcaatgagc actagtgctc ttgccagcgg ttggtgatgg ggaggcggcg gtcgcggccg
     5461 aagttcttcg gggtgatctt ggggccgggc gggtactggc ggcgcttgta ctcggcgagg
     5521 tcgaccaggc ggatgacgcg gtcggccagg gcggggtcgt ggccggcggc gacgagggcg
     5581 tcgcggccga ggtcgcgctc gacgtagtcg gcgaggagcg ggtcgaggac ggcgtagtcg
     5641 gggaggctgt cgatgtcgcg ctggccgggg cgcagctcgg cggacggctc cttgtcgatg
     5701 atcgcctgcg ggatcggctc ctgcgcgaac gggtgcagga acggcaggtc gacgccggcc
     5761 tgggcgtcgc gccagcgggc gaggtcccac acggtggact tgaagacgtc cttgatgggg
     5821 gcgaacccgc ccgccgagtc gccgtagagg gtggagtagc cggtggccag ctcgctcttg
     5881 ttgccgccgg tgaggacgag gtggccgtgc tcgttggaca ggcccatcca gacgttggcg
     5941 cggatgcggg cctgcaggtt ctcggcggcg aggccgtgca ggtcgagttc gtcctcgaac
     6001 gcgtcgacca tgtcggcgat cgggacgatc cgggcgttga tcccctggcg tttgacgagg
     6061 tcctcggcgt cggtgacgga gccctcggag gagtagcggc tcggcagcag gacggcgtgc
     6121 acgttctcgg ggccgagggc gtcggaggcg atggtggcga cgagcgcgga gtcgatgccg
     6181 ccggacagcc cgaggatgac cgagcggaag ccgttcttgc ggacgtagtc gcgggtgccg
     6241 aggacgagcg cggcgtagat ctcggcgagg tcgtcgagcg gggcggcgac ggtctgcggt
     6301 gcgacggggt aggcgggcac cggacggggg gacagcacga tccggtcgag ggtgatggtg
     6361 gtgccgtcgt gcgcgtcgac cggggtgcgg ccgggctcgg cggtgggacc ggcggcgggc
     6421 agcgcgaggt cggcgacgag gaggtgctcg acgaactggg gcgcgcgggc gagcagggag
     6481 ccgtccgcgc cgacgatgat cgagtcgccg tcgaagacca gctcgtcctg gccgccgacc
     6541 atgttgacgt aggcgagcgc gcagccggcc tcgcgggcgc gcgcggcgca caggtcgagg
     6601 cggacgtcgt ccttgtcgcg ttcgtagggg gaggcgttga ggacaagcag cagcccggcg
     6661 ccggcctcgc cggcgacgcc gacggggccg ccgtcctgcc agaggtcctc gcagatcgcg
     6721 gtggcgacgt cgacgccgtg gacgcggacg accggcagcc ggtcgccgcg cacgaagacg
     6781 cggtactcgt cgaacacgcc gtagttgggc aggtggtgct tggcggaccg gacgagcacc
     6841 tcgccgcggt gcagccaggc ggcggcgttc agcggcaggc cggacggctg cccggcgcgg
     6901 acgagcccga cgggcggccg gtcgaggtgg ccggtgacga ccggcaggtc gccgaggccc
     6961 tcgtcggcga gccgcgcggc gacgcgttcg agggcgtgcc gggacgcctc gacgaaggag
     7021 ccgcgcaggg cgaggtcctc gacggggtag ccggtcagca tcatctcggg gaaggcggcc
     7081 agatgcgcgc ccgcggcggc ggcgcgggcg gcccattcca cgatcagtcc ggcgttgccg
     7141 tcgaggtcgc cgacggtcgg gttcacctgc gcgagcgcga tcctcagctg tgccacggcg
     7201 cccagcctag ttccgccgca gtggtttcgt cactatgacg agaaggagtc gtcgatcacc
     7261 gcggcgcggc gccgccggac ggccggggcg agcgcgagct gcccggcggc ggcggcgagc
     7321 gcgagcccgg tgcagctcag ccagagcagc gccggcccgc cggtgccgag cagctgcgtg
     7381 ccgccgagcg gcgccagcag gaacccgccc gaccacgcca tcccgtacag gccgctgtag
     7441 cggccgcgca ggtgcggcgg cgcgaggtcg gcgacgacgg cctgcagcac ggacgcggcg
     7501 gtgatctcgc cgagcgtcca gaccaggatc gtcgcggtga agccgggcag cgaggacacc
     7561 agcgcggtca gcccgtagcc ggcgccgacc agcacgaacc cggccaccat caccaggctg
     7621 tggtcgcgcc ggctcagcca cgcgttgacc agcggctgca cgatgatgat cagcgcgccg
     7681 ttggcggcga tggcgatgcc gtagtcctgc ggcccgagcc ccgcctcctt catcgcgagc
     7741 ggcatcgtcg tcatgccctg catcagcacg aacgtgtagc acagcatcac cgccgcgtag
     7801 ccgaccatga cccggtcgcg cagcacctgg acgaacccgc ccggcccgtc ctcccggccg
     7861 ccgccgcgca cccgggtctc cgggacggcg cgccacacca gcaccccgaa cgccgcgcag
     7921 gtcagggcgt cgatccagaa cagcagctgg aagccctcgc gggcgagggt gccgccgagc
     7981 accatcgaga acgcccagcc gaggttgacc gcccagaaca gcagcccgaa cgcccgcggc
     8041 cgctccgcgg gcgagatgat gtcggcgacc atcgcctgcg acgcgggccg gtacatgtcc
     8101 agcagcaggc cgaggacgag cgccgcgacc gtgatcatcg cgatcccgtg cgcgtagccg
     8161 agcgcgagca tcgccgcgcc cgtcccgacg gtcgcggtgg tcagcgtcgc gcggcggccg
     8221 atccggtcgg cgagcgcgcc gcccgcgatc tgcccggcga acgagcccgc gccgagcacc
     8281 gccatcacgg cgcccgcctg ccccagcgac aggccccgcg ccgtggtcag gtacaggccg
     8341 aggaacggct cgaccatcgt gccgagccgg ttgaggaggg tgcctgccca cagcacccag
     8401 aacgtccggg gcaggccgcc gacccgcggc cgcaggaacg tcgcgatccg gcccgccggg
     8461 ggaccgacag gagtgtcgtc caatgtggtc acttgcacga tggtccggga acgcggcgga
     8521 catcggcatt gatttagtgt gggctaaatg accgaggtcg cgcagtgatc gagttcgtgt
     8581 tcgcgccgga cgacgccgcc cgcgtccggt tcgcgttctc gccgctgtgg gagatggtgc
     8641 gcagcctgcg ggtgctcacc gacccctccg ggcgcgcgct gcacctgccc tgggtgcacg
     8701 gcgtccggcc ccggctgcgc ggcctcggcg tcgagccgct gctggcggtc gtcccgtcca
     8761 cggggtacat ccccgacttc ctcacgccgc cgccggagac gccgctgccc gacctgggcg
     8821 ccgagctgga gaccgtccgc aacacgccgc ccgaggtcgt cgccgacgag ctgagctgga
     8881 ccgagccggg ccgccgcgcg gaccccgcgc gcctggcgct ggccgccgac cccgaacgca
     8941 ccctcgagac gctcgccgac ctgctcgaac ggtactgggc tgcggccgtg gagccgtact
     9001 ggccgcggct gcgcgacctc ctcgagggcg acgtcctgcg ccgcacccgc gcgctcgccg
     9061 cgcacggcat cgccggggtg ttcggcgacc tgcacgacga cgtccgctgg cgctcgggaa
     9121 ccctgatgat cgaccggcgg tgggactttc gcggcgagct gctcggccgc gggctgctgc
     9181 tggtcccgag cgcgttcgtg tggccgcacg tgtcggtcat ggtgccgccc taccagccga
     9241 tgctcagcta cccgccgaac ggcgtcggga cgctgtggga gaccggccgc gaccgcggcg
     9301 cgggcccggg cgccctggcc gcgctgatcg gccgccgccg cgccgagctg ctcaccgccc
     9361 tcgccacgcc cgcgtccacg acggaactgg ccgcccgcat gggcgtgacc gccggcgcgg
     9421 tcagccagca cctcggcgtc ctccgcgcct gcggcctggt cacgggccac cgcctgggcc
     9481 gccgcgtcct ctacgcccgt acccccaccg gcgacaccct cgccaccagt accggcaacg
     9541 gccgccgccg atcccccgac cgcccgtaag cccgcccccg caccgacccg agcgcagccc
     9601 gattagagcc cgttcgccga cagcaagacg atcgtccgca agaccaacca cgcaccgacc
     9661 cgagcgccgc gaccgccgac agtaagacga tcgtccgtag gcccggcccc gcgccgacat
     9721 acgcgttgtg atcgcgagcg cggccggctt cgagcacgtt cgccgtccgc cagccgaccg
     9781 tccgtaagcc cggccatgcg ccggcctacg cgttgcgatc gcgtgcgaag ccggattcga
     9841 gcttgcgaga atccgatcgc gcagcgaggc ccccagggcc gagccggagc gatgcagcga
     9901 tcgccgcaga atccgccgaa ggagggcgcc ctggcgcccg acgccaagga ttctgcagtc
     9961 gacgaagcga tcgccgcaga atccgccgaa ggagggcgcc ctagcgcccg acgccaagga
    10021 ttctgcaatc agacagagcg ttgaggcgga gttgggcggg tgcggcggat tcgtagcggc
    10081 cggattcggc gagccagtcc atgtgggcgc gcggggtgtc cagcagcacc ttgacgacct
    10141 gcgcggcggc ggcgcgttgc gcgacggtca gttgcagccg gtcgagcatc tccggcaggc
    10201 ggcgggccgc cttccatgcc tgctcgagcc gcgccgcgat gcggtcggcg accagttcgg
    10261 cggcctgctc gggcgcgagg tggtgcgccg ccgcgaggac ggccggcagg ccgtgcacgt
    10321 cgccgcgcgc gctctccatc tcgtgcgagg cgaggtcgtt ggaccaggcg acgacgtccg
    10381 cgacgctctc ggcgaccgtc agccagcggg gcgtgcggag cagccgcgcg ggcagttcga
    10441 cgccgagcac cggttcgacg aggtcgtaca ggaacggccc gcacgcgcgg cggcgcagcg
    10501 cggcgaactc cggcggcgtc gggacgtgcc ggatgcgccg gttcacggcc tcctcggcgc
    10561 agccgtcgcg gtgcgcctcc agctgcagga tgaaccgcct tcgccagtcc cggctcatcc
    10621 ccttggacgt ggcctgccag agttcgacca gcgcggactc cagcgggcgg gcgccgggcc
    10681 gggcgtggcc gcgccgcatg gcgcgcagca ggtcgtcgta cagggcgtgc acggcgctgc
    10741 cgctgtcggc gagcggcgga tggtcgaggg tgtcgtccag tgcgagcgcc caggtgagcc
    10801 agcgcgcgaa caggtcgacg gaggccagtt ccgcgtccgg gaagacgcgg gcggccagtc
    10861 gctcgcagcg ggcgcggccg agcggcgagg tgtccggatc tccgagcacc aggccgcggc
    10921 cgcgcgccca ggcctccacc tgcgcgccca gctgccagga ctccgggtgc atggccgacg
    10981 gggaggccag cgcggccgcc cggtcggtca tcgagagaag aagagagatg tccacgacac
    11041 ggcccacgct aatgatcaac gtccggacgg accatgatcg caacgtcaat tctcgggcaa
    11101 caccgggcgc gccgggtcag ggcggggtat gccgtgcgcc caggtcggca tggcatagtt
    11161 cggggatcgc gaagagctcg actcaggagg aaacgtgtcc agacggacca tgcgttgggc
    11221 actgtgcgcg ggtgtcgccg ccctcgcgct gaccgcttcg gcgtgcggcg gcagcgacgg
    11281 cgcgaccgtg cagggcgtga agctgatcaa gaagggcgcg ctgacctcgt gcacccatct
    11341 gccctacccg ccgttccagg tggagcaggg cggcaaggtg gtcggcttcg acgtcgacat
    11401 gatcgacctc gtcgccaaga agctgggcgt gacccagaag gtcgtcgaca ccccgttcga
    11461 gacgatgaag acgggcgcgg cgctgaacgc cggcaagtgc gacatcgtca tgggcggcat
    11521 gacgatcaag ccggaccggg tgaagttcat ggacgtgagc gagccgtact tcgacgccac
    11581 gcagtcgctg atggcgaaga agggcagcgg catcacgagc ctggaggacg tgaaggccaa
    11641 gaagctgaag ctgggctcgc aggcgagcac caccggtgag gacttcgtca agggcaaggg
    11701 cttcgacccg tcctcgttcg acaactccaa cgccgagctg gacggcctgc gcaccggcca
    11761 ggtggacgtg atcgtgcagg acgacccggt cgtgaagggc tggctgaagg acccggcgaa
    11821 ctccaagtac gagatcgtcg cgaacctcaa caccggcgag cagtacgggt tctggatccg
    11881 caaggactac aacaagaagc tcgtcgagct gacgaaccag gcgatccagc aggcgaagca
    11941 ggacggcacc tacaagaaga tctacgagaa gtggatcggt cccatgccgg ccgccgccgg
    12001 taagccgtcg tgaccacgga gcaggtgacg cccgtcgcgg cgcccggcgg gctgtcccgc
    12061 cgggcccgcc ggcggctgtc gctgggcggc cagtacggcc tgttcatcgt catcgtggtg
    12121 ctggtcgcgt cgctggcgaa ctggccgcag ctgcacacga acttcgccaa ctggcaggtc
    12181 gccaaggggc tgttcccgga gatcatcacc gtcgggctgc gcaacaccgc gacctacacc
    12241 gcggtcgggt tcggcatcgg gctggtcctc ggcctcgtcg tcgcgctgat gcggctgtcg
    12301 cccgtgctgc cgtaccgctg gttcgccacg gcctacatcg agatgttccg cggcctgccg
    12361 ctgctgctga tcttcatctt cgtcggcgtc ggcgtgccgc tggcgttccc cggcacgaac
    12421 atcccgggcg gcgcggtcgg gcaggcgggc ctcgccctcg ggctggccgc cgccgcgtac
    12481 atggcggaga cgatccgggc cggcatcgag gcggtcccga aggggcagct ggaggcggcg
    12541 cgctcgctcg gcatgtcgca gggccggtcg atgcggtcga tcatcctgcc gcaggcgttc
    12601 cggatcatca tcccgccgct caccaacgag ctggtgctgc tgtgcaagga ctcctcgctg
    12661 gtgctgttcc tcggcatcac gctggagcag cgcgagctca ccaagttcgg tcgggacctc
    12721 gccggccagc agggcaacac cacgccgatc atcgtggcgg gcatctgcta cctgatcatc
    12781 acgatcccgc tgagcctgct ggccaggcgg ctggaggcgc ggcagcgcag ggagcagcga
    12841 tgacgatcat ggagaaggac gccggccggg cgggcggcac cggccgggcc gtcgagatca
    12901 gcgggctgca caagtcgttc ggctccaacg aggtgttgcg gggcatcgac ttccacgtcg
    12961 agcgcggcga ggtggtgtgc gtcatcggcc cgtccgggtc gggcaagtcg acgctgctgc
    13021 gctgcgtgaa cctgctggag gagccgaccg cgggcacggt gcgggtcgcc ggcgccgaga
    13081 tcaccgaccc cgacgtcgac atcgacgcgg tgcgccgccg gatcggcatg gtgttccagt
    13141 cgttcaacct gttcccgcac ctcaccgcgc tcggcaacgt gacgatcgcg cagcgcaagg
    13201 tgctgaagcg ggacaaggcg gaggccgagc ggatcgcccg cgagaacctg gagcgggtcg
    13261 ggctcgccga caaggtggac gcctacccgg gcaagctgtc cggcgggcag cagcagcgcg
    13321 tcgcgatcgc ccgcgcgctc gcgatgggcc ccgaggtgat gctgttcgac gagccgacgt
    13381 cggcgctgga ccccgagctc gtcggcgacg tcctcggcgt catgcgcggc ctcgccgagg
    13441 cggggatgac catgctcgtc gtcacgcacg agatgtcgtt cgcgcgcgag gtcgccgacc
    13501 gggtcgtgtt catggacggc ggcgtggtcg tcgaggaggg cccgccggcg cgggtgatct
    13561 ccgccccgga gcacgagcgg acccgcgcgt tcctgtcccg ggtgctcgat ccggcggccg
    13621 cccgcgtgga aggttccggt ccgtcggata agttcggttc tgacgaggcg aacgcgtaac
    13681 gtcgcggtaa cagcgtccgg gcatactgca acttgggccg gacaatgcgg ccggcaccgc
    13741 gtcaccgagg gagagggctt tggaccgtca gcaggagttc gtgctccgca cgctggagga
    13801 gcgcgacatc cgcttcatcc ggctgtggtt caccgacgtg ctcgggttcc tgaagtcggt
    13861 ggccgtggcg cccgccgaac tggagggcgc cttcggcgag ggcatcgggt tcgacggctc
    13921 ggcgatcgag ggcttcgccc gggtgtacga ggccgacatg atcgccaagc ccgacccgtc
    13981 caccttccag gtgctgccgt ggcgctcgga gtcgcccggc gtcggccgga tgttctgcga
    14041 catcctgatg ccggacggcg cgccgagctt cgccgacccg cgctacgtgc tgaagcgcgc
    14101 gctggcccgc gccgccgacc tcgggttcac cttctacacc caccccgaga tcgagttctt
    14161 cctgctcaac gacaagccgg aggacggcag cgagcccgag ccggcggacg cgggcggcta
    14221 cttcgaccac accccgcaca gcgccgcgca cgacttccgg cgcaacgcga tcatgatgct
    14281 ggaggcgatg ggcatctcgg tggagttcag ccaccacgag ggcgcccccg gccagcagga
    14341 gatcgacctg cggtacgccg acgccctcac caccgccgac aacatcatga cgttccggct
    14401 ggtgatgaag gaggtcgcgc tcgaccaggg cgtgcacgcc accttcatgc cgaagccgtt
    14461 caccgagcac cccggctccg gcatgcacac ccacatgtcg ctgttcgagg gcgaccgcaa
    14521 cgccttcttc gagccgggcg cggagtacaa gctctccaag gtcggccgcg cgttcatcgc
    14581 gggcctgctg cggcactccg ccgagatcac cgcggtgtgc aaccagtggg tcaactccta
    14641 caagcggctg tggggcaacg tcggctccgc ggcgggcgcc gggggagagg ccccgtccta
    14701 catctgctgg ggccacaaca accggtccgc gctcgtccgc gtgccgatgt acaagccgca
    14761 caagggccac tcgacccgca tcgagttccg gtcgctggac accgccgcca acccgtacct
    14821 ggcgttcgcg gcgatcctcg gcgccggcct caagggcatc gaggagggct acgagctgcc
    14881 gcagggcgcc gaggacgacg tgtgggcgct caccccggcc gagcggcgcg ccctcggcat
    14941 cgagccgctg ccgcagaacc tcgacgaggc cgtccacgcg atggagcgca gcgagctgat
    15001 ggcggacgtc ctcggcgagc acgtgttcga cttcttcctg cgcaacaagc gccaggagtg
    15061 ggaggactac cgcaggcagg tcaccgagtt cgagcgcaag aggctgctgg cggtcctctg
    15121 accggaatac ggtggggacc gtgagcgagc cgtggacctc cgaccgccga cgtccgtccc
    15181 tcgccggccg gctggcgcgg ctcgggttca ccgacgcggg acgcgccgag cggctgctgg
    15241 cggaggccga gcgggacgcc ggcgcggcga tcggcgacga tctcctcgac gcgctgggcg
    15301 gcaccgccga ccccgacctc gcgctgaacg gcctgctgcg ggtgctcgcg tccgccgcgg
    15361 agcggggcgt cgccgacgag ctgcgggcgg cgctgcaccg ggagccgggc acccgggagc
    15421 ggatcgccgc cgtcctcggg gtgagcgacg cgctcgccga ccacctcgtc cggcatccgg
    15481 agcactggcg ggtcctccgc gacgacggcg cgccgggcga gccgggccgc ccgtcggcgg
    15541 ccgcgctgcg caccgggctg ctggaggcgg tgggcgccga cccgtccgcc gaggacccgg
    15601 tggcgtccgg ggcgggcacc gaggcgctcg tcgcgctgcg cgccgcgtac cgggcgcggg
    15661 tgctgtcgct ggcgggccgc gacctgatcg gagtcgcgga cgtggcggag gtcgccgcgg
    15721 agctggccga cctcgccgcc gccgcgctgg aggcgggcct cgcgatcgcc cgcgcggagg
    15781 tcgacgggca cgccgcctgc cggctcgcgg tgatcgggat gggcaagtgc ggcggccgcg
    15841 agctgaacta cgtcagcgac gtcgatgtga tcttcgtggc ggaagcgcgc gagggtgtgg
    15901 acgaggacgc cgcgctgcgc accgcgaccc ggctggcctc ggcgatgatg cgggcctgct
    15961 ccgcctcgac ggaggagggc gcgctctggg aggtggacgc ggcgctgcgt cccgagggca
    16021 aggccggccc cctcgtgcgg accctcgcca gccaccgcgc ctactacgag cggtgggcca
    16081 agacctggga gttccaggcg ctgctgaagg cccgccccat cgccggcgac ccggggctcg
    16141 gcgcccggta catggacgcg atcaccccga tcgtctggaa ggccgccgag ggggagagct
    16201 tcgtccagga cgtccaggac atgcggcgcc gcgtcgagaa ggacctggac cgccgcaccg
    16261 gcgactccga gcggcagctc aagctcggcc ccggcggcct gcgcgacgtc gagttcgccg
    16321 tgcagctgct gcagctcgtg cacggccgcg ccgacgcgac gctgcgcagc ccgggcaccc
    16381 tggacgcgct cgccgagctg tcccagggcg gctacgtcgg gcgcgacgac gcggcggcgc
    16441 tggcctcggc gtaccggttc ctgcggcgcg tcgagcacct gatccagctg caccacctgc
    16501 gccgcaccca cctcgtcccc gacgacgcgg cggacctgcg gcgcctcggc cgcgccctcg
    16561 ggctgcgcac cgacccggtc ggcgagttca ccgcgctgtg gcggcggcac gcccgcgagg
    16621 tccgccgcat ccacgagaag ctgttctacc ggccgctgct gcgcgccgtg gcgcggctgc
    16681 cgggggagga ggcccggctc accccggagg ccgcccgcac ccggctggag gcgctcggct
    16741 acgccgaccc ggcgggcgcc ctgcggcaca tcgaggcgct cacctcgggc gtgtcgcggc
    16801 gcgccgcgat ccagcggacg ctgctgccgg tgatgctcgg ctggttcgcc gacgcgcccg
    16861 accccgacgc cgggctgctg gggttccgga aggtcagcga cgcgctcggc accacgccgt
    16921 ggtacctgcg gctgctgcgc gacgaggtga gcgtcgccga gcggatggcg tgcctgctcg
    16981 ggtccagccg gtacgccacg gacctgctgc tgcgcgcccc cgaggccgtc gcgctgctcg
    17041 tcggcgccga cgggctccgg ccgcgcccgc acgaggcgct gcgggccgag atgctcgccg
    17101 cggtccgccg gcacgccgag ggcggcggcc cggcggagga ggcggtcgcg gtcgtgcgcg
    17161 ggctgcgccg ccgcgagctg ttccgcgtgt cggccgccga cctgctcggc ctcgccgacg
    17221 tggagacggt cggcgcggcg ctcaccgaca tcgccgccgt cacgatcgag gccgcgctgc
    17281 gcgccgccgt cagcaagatc gagatggagg cgcgggagcc gctgccgacc cggatggcgg
    17341 tggtcgccat gggccggttc ggcggccacg agctcggcta cggcagcgac gccgacgtga
    17401 tgttcgtgca cgacccgtgc cccggcgcgg acgagcgggc cgcgggccgc gccgcgcacg
    17461 ccgtcgccga ggagctgcgc cggctgctcg cgctgcccgc ccccgacccg ccgctggaca
    17521 tcgacccgaa cctgcgcccg gagggccgcc aggggccgct cgtgcgcacc ctcgcctcct
    17581 acgcggcgta ctaccggcgc tggtcgcagc cgtgggaggc gcaggcgctg ctgcgcgccg
    17641 accccgtgat cggcgacccg gggctgtgcg agcggttccg cgcgctgatc gacccgatcc
    17701 gctggccgga ggacggcgtc ggcgaggacg cgctgcgcca gatcaggacg ctgaaggcgc
    17761 ggatggagtc ggagcggctg ccgcgcggcg tggaccgccg gctgcacatc aagctcggcc
    17821 cgggcggcct gtcggacgtg gagtgggtcg cgcagctgct gcagctgcgg cacgcccacg
    17881 cggtcccggc gctgcgcacc acccggaccc tcgcggccct ggaggcggcg gcggacgcgg
    17941 ggctgctgga ccgcgacgac gcggaggtgc tgacggacgc gtggtgcctg gcgacccgga
    18001 tccgcggctc gctcatgctg gtgcggggcc gcgcgtcgga cctgctgccg accgaccacc
    18061 accgggagcg caccgccgtc agcagcgtcc tcggctatcc gggggccggc gccctgctgg
    18121 aggactacca gcggcacgcc cgccgcgccc gcgcggtcgt ggaccgcgtc ttctacggcg
    18181 ccgaggactg atcgcggggc cggccggtca cgggcggtcc gggcgcgagc cgtccgggcg
    18241 cgggtgatcc gggcccggcg gcgggccgga cccggatcag cagcgcgatc ccgacgcggc
    18301 tcccgcggcc ccgtcggggc ggcgggagcc gtgcgggtgc cggatccgct ggacggcccg
    18361 gtcccgcagg tcgatgaccg gctgcgggca ccgggtgtag agcagccagg cgacgccgag
    18421 cgatccgccg atcagcgcca tcccgatcac cgcgtccagc acgtagtggt tggcggtcga
    18481 caggatcacg aacaccgtgg tcgcggggta gatcacgccg agcaccttcg cccagcgctg
    18541 cgagacgaac ttgaccagca cgaacccgca ccacagcgcc cagccggcgt gcatcgacgg
    18601 catcgccgcg tactggttgg tgaggctgcc ggacgcgtcg ctggagtaca gcccgaagga
    18661 gtgcaggtag gtcaccgggt cgacgaaccc ggcgctgtgc aggaaccgcg gcggcgcgag
    18721 cgggtacagc cagaagccga tcagggccag cgcggtcgcc gccatgatcc cggtgcgcag
    18781 ccagcggtac tcccgcggcc ggtaccggta cagccagacg acgaccagcg ccgtcaggat
    18841 gaagtgcatg gtggcgtaga acatgttggc ggtgcgggcg agccacggca cgttgatcag
    18901 cgtcttgttc aggcccagtt ccacgtccag gcccaccagc ttctccgcgt gcaggatctg
    18961 gtaggcgtgc gtgaacgcag ggccggtgcc gtcctgaacc aggacgatgc gcgtcagcgt
    19021 atagcccgtg tagaagagca cgagcaggag cagctcgcgc cacaccggcg gtgccgtgag
    19081 cacccggggc cgcttcgtcg cggcgctgcg tcgcggctca ccgcggccgg cgtcggaccg
    19141 gcctcggcgc gctgctgggg gggcggaatg agccatgcta cctatctttg cctcgcggcc
    19201 cccagttgag atcaccgccg cgaatggtct tcgtctcaga cctgagtagt acgaccccga
    19261 cgcggcatcc ggactttcgg gggaggggcc cctgaggtgc cggggtcctg cctccgtatg
    19321 gagcctgtga acttgatcag gaatcagcat aggaggcgtt gggtagatca tcgtcggccc
    19381 cccacgaacg agcaggggga cgaatggcgt tgatcgggtc catacccggc attacgacgg
    19441 caagcacggc gacgctggcc gctttcggac tgatctcgtg ctccggatgg gcggacggcc
    19501 cggacggttc ggcggccgtc cgcgcggccg ccgccgtgac cggcgggacc gtcccgaagc
    19561 cggtgtggcg gccctgcacc ggcctcccgg cccccgacca gggcgtctcg caggcccggt
    19621 accggtgcgc gaccctgcgg gtccccctcg accacgcgga cccgtcctcc gggacgatcg
    19681 gcatcgcgct gatgaagatc ccggcgaagg gccccggccg ccggatcggc tcgctgctgt
    19741 tcaacttcgg cgggccgggc ggcgacggcg tcgacaccct cgcccaggcc gcgccgcagt
    19801 acgccaccct caacgcccgc tacgacctgg tcggcttcga cccgcgcggc gtcggccgca
    19861 gcgccccggt cacctgcgtg gacgaccgga ccatggacca gatcgccgcc gaggacgaca
    19921 cccccgacac gcccgccgag gagaccgcct acctcgcgcg gcgcgcgtcc tacgcccggg
    19981 cgtgcgaggc gaggtcgggc aggctgctgc cccatgtcgg gacgctcagc gccgcccgcg
    20041 acctggacgc gatccgcgaa gccgtcggcg acccgaagct gaactacttc gggatctcct
    20101 acggcacgtg gctcggcggc aactacgccc accagttccc cggcggcgtc gggcgcgccg
    20161 tcctggacgg ggcggtcgac acccggctga acaccgccga cctgggactc cagcaggccg
    20221 ccgggttcca gcgcgccctg gtcgacttcg gcgcggcctg cgcgaagctc ggcgcgaagt
    20281 cgtgccccct cggcggcgac ggcgagtccg tcgcggcggc caccgggaag atcctcgcta
    20341 gcctcgaccg caagccgctc aagacgtccg gaggccgcaa gctcacgcag agcctcggcg
    20401 acaccggcgc cgccgcggcg ctctacagca agcaggcgtg gccctacctc gcccaggggc
    20461 tcgtcgacgc cgtcaagcgc cacgacggga cgctgctgct gatgctcgcg gacctgcaga
    20521 acggccgcaa gagcagcggc gcctacgcca acctgacggc cgcgaacacc gcgatcacct
    20581 gcgcggacgg ctccgaccgc tacaccgtcg ccgacgtccg ccggctgatg ccggcgttcc
    20641 gcaaggcctc cccggtcttc gggccgtcga tggcgtgggg cctgctgcag tgcacgggct
    20701 ggcccgtcaa gggcgacgac gcggcgcgcg aggtgtccgc cccggacgcc gcgccgatcc
    20761 tggtcgtcgg caacaccggc gaccccgcca ccccgtacgc gtgggcgtcc gcgctcgtga
    20821 agtcgctcgg cgggagcgcc gcgctcctca ccctcaaggg ggaggggcac ggcgcgtacg
    20881 acaccggcga cccctgcgtc cgccgcgtcg tcgactccta cctgctggac gggctgctcc
    20941 cggcggccgg cgcgacgtgc ggctgatccc cgtgccggca ggcgcggcgt cagacgatct
    21001 ggtcgatctt c
//
