LOCUS       NZ_CP053892            22538 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8150303
            Orig. end                         :: 8172841
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..22538
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="23"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22538
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22538
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12538](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12538
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    complement(37..48)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.75"
                     /tool="antismash"
     misc_feature    101..115
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.08"
                     /tool="antismash"
     gene            573..887
                     /gene="rsrA"
                     /locus_tag="ACTIVE_RS36620"
                     /old_locus_tag="ACTIVE_7347"
     CDS             573..887
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633248.1"
                     /locus_tag="ACTIVE_RS36620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7347"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_173099265.1"
                     /transl_table=11
                     /translation="MSCGDHHETSCEEVLARVYSYLDGELDQGGCGEVREHLDECGPCL
                     REYGLEEAVKKIVNKSCGCEQAPAELRSKVLGRIEEICGEIKATGGGVAAGGTGASESA
                     "
     gene            1034..1951
                     /locus_tag="ACTIVE_RS36625"
                     /old_locus_tag="ACTIVE_7348"
     CDS             1034..1951
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (59-219). E-value:
                     1.5e-11. Score: 35.8. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS36625_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633247.1"
                     /locus_tag="ACTIVE_RS36625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7348"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_173099266.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.2e-17, bitscore:
                     63.0, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 8.1e-09,
                     bitscore: 34.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLALVTGAAGFIGSHLVDRLLADGHEVVGVDDLSSGANQNPAIEL
                     WRMDVADPALAERMAARRPEVVCHLAAQVSVRASVADPLHDARVNVTGTANVLEAARAA
                     GSRKVVFTSSCAVYGVPDALPVPPDAPLRPASPYAASKVSGEVYAGMYRALHGLDFTTL
                     TLANVYGPRQTPEGEAGVISIFTDALLAGRPTTVFGDGKQTRDYVYVLDVVDAFARAAG
                     EAGGGGRFNVGTGLQTTDRDLHALVAAAVGAPDEPEFAPPRLGDLPAMAVDPGPTREAL
                     GWEPRVSLVDGLAETAAWARGRTA"
     aSDomain        1211..1690
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS36625_NAD_binding_4.1"
                     /evalue="1.50E-11"
                     /label="ACTIVE_RS36625_NAD_binding_4.1"
                     /locus_tag="ACTIVE_RS36625"
                     /protein_end="219"
                     /protein_start="59"
                     /score="35.8"
                     /tool="antismash"
                     /translation="AARRPEVVCHLAAQVSVRASVADPLHDARVNVTGTANVLEAARAA
                     GSRKVVFTSSCAVYGVPDALPVPPDAPLRPASPYAASKVSGEVYAGMYRALHGLDFTTL
                     TLANVYGPRQTPEGEAGVISIFTDALLAGRPTTVFGDGKQTRDYVYVLDVVDAFAR"
     misc_feature    2068..2081
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.32"
                     /tool="antismash"
     misc_feature    complement(2091..2107)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 24.84"
                     /tool="antismash"
     misc_feature    2135..2148
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.99"
                     /tool="antismash"
     misc_feature    complement(2140..2153)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.79"
                     /tool="antismash"
     misc_feature    2160..2175
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.21"
                     /tool="antismash"
     gene            2518..3864
                     /locus_tag="ACTIVE_RS36630"
                     /old_locus_tag="ACTIVE_7350"
     CDS             2518..3864
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658387.1"
                     /locus_tag="ACTIVE_RS36630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7350"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_173099267.1"
                     /transl_table=11
                     /translation="MRGLPLAAWAYVCGVVALAAALIATSSFTGVDWTKLAVLALLFLI
                     CDSAPARLNVERARVSLSFAASLAGVVLLGPAGAALLGLSALVTGQRFFAPEKRAFNGA
                     QFALSGFCAGTVFDLLGGDRFHPEQSRWVENVIGPFLGALVTFVLVNLLLMAGVLLLSR
                     QAAPRELLHESGQLAVGCLGYGMVGLLIAGLWPRIGAFAAVLVLLPLFIARWAMDQAYA
                     QQQAHAATLAALCQAVETKDYYTRGHSERVSRGSVMIAQEIGMRADRVEAIRYAGMLHD
                     VGKLGVPTKVLQKSGSLTEEEFAAIQLHPMRGLEIVREIGFLDEALAGIMHHHEKVNGR
                     GYPMGLAGDEIPEFARVISVADAFDSMTSTRSYRAARTVAEAVAELRRGMGDHFDPVMV
                     EAFLRALDRDGWEPPRPVVLPDDDVVETTQQDHDDPSAPLRVAGDEARR"
     gene            3876..5219
                     /locus_tag="ACTIVE_RS36635"
                     /old_locus_tag="ACTIVE_7351"
     CDS             3876..5219
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658386.1"
                     /locus_tag="ACTIVE_RS36635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7351"
                     /product="HD domain-containing phosphohydrolase"
                     /protein_id="WP_173099268.1"
                     /transl_table=11
                     /translation="MSSTQIRARRERAAWQTIDSGQLLLIATAGLFVVVAIAEVAAAGL
                     RQANVAIIFGVLIALGELFRMVMPGNREVAPIASAGAMGYALLVGIGPEGAPPDAPLGV
                     VPAEHSPLQVVAVTSVGMLVGSLPHILVGRSPRPDAMARRLFTVAVVALCFRPMLSLGL
                     PWQLLLAVMGLVVVLSCFTDVLIAAMIRAEAVRARFGIALRDEIDAKMALCAATSATAM
                     LIAVATTAMGEAALLIFTVPILVTQFAFRRYAGIRATYLQTVRALSRVTEVGGYVETGH
                     SRRVSRLSVAMGRELGMSEEELLELEYAALMHDIGQLSLGDPIPGGATVLASPAEQRRI
                     AELGAEVIKQTGVLDRVAHIVQLSSHPYRTGPETLAGPGEAGQPVPAPPLAGRIIKVAN
                     AYDDLVGDSADRDRGAAVLERLRLDSAAEYDPTVVEALSRVVDRRPRP"
     gene            5378..6712
                     /locus_tag="ACTIVE_RS36640"
                     /old_locus_tag="ACTIVE_7352"
     CDS             5378..6712
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633243.1"
                     /locus_tag="ACTIVE_RS36640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7352"
                     /product="biotin carboxylase N-terminal domain-containing
                     protein"
                     /protein_id="WP_173099269.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.7e-11,
                     bitscore: 42.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 4.3e-05, bitscore:
                     22.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFESVLVANRGEIAGRVVRTAQAMGLKAIAVYSEADAGLPYVAEA
                     DEAVLIGPADPARSYLNAAAVLEAAQRTNAQAVHPGYGFLAESAPFARAVAARDLVWVG
                     PPPLVVARMGDKINARNLMKEAGVPVSPGAWEPVRDAATAVEEAERIGYPVMVKPAAGG
                     GGAGLGSAYDAETLRTAFEAAHTAATRLFGHGDVLLERYVEGVRHVEVQILGLVDGTVV
                     ALGERECSVQRRYQKVAEETPSPGVGAALRERMLAAAVRAGEAVGYRGVGTVEFLVDPV
                     AQEFFFLELTARLQIEHPVTEMVTGVDLVEQQFRIAAGEQVAPPAAPRGHAIEFRVHAE
                     DPQGFRPGAGEIKVWEEPVGDGIRIDAGYYEGNTVTPYYDSLLAKLCVHGDDRAHALAR
                     ARAALGAFRIEGIATNLPFFAELLDHREFIDGTYDSGVVARMRIR"
     gene            complement(6728..7618)
                     /locus_tag="ACTIVE_RS36645"
                     /old_locus_tag="ACTIVE_7353"
     CDS             complement(6728..7618)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.4"
                     /locus_tag="ACTIVE_RS36645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7353"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_173099270.1"
                     /transl_table=11
                     /translation="MTVLASAWPALIAVLLVAAGGKVRDVRGFAAAIGAYRVLPARLTG
                     AAAVAVLSAEAAAAVLLAVPATRRWGALAAAALFAAFLGAMASVLRRGMVIDCGCFGSA
                     RRPAPVGAASVTRTALLLLLAVMAAVAGPAPFSPLQPVLAAVFVGAVAAVPRPRPGVAE
                     PEASPPAGPRPGTPFALNSAIEAPTVFALISPACGLCRTMLPVFAEAASGRRVVLVSAA
                     DEDGVRRHLDEHGVGDLPLVTDPDVYDANGIPWPPYVVVTDDAGTVLAAGGADTPPRFR
                     ALLHRADSAGARPAG"
     gene            complement(7615..9513)
                     /locus_tag="ACTIVE_RS36650"
                     /old_locus_tag="ACTIVE_7354"
     CDS             complement(7615..9513)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543927.1"
                     /locus_tag="ACTIVE_RS36650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7354"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_343062967.1"
                     /transl_table=11
                     /translation="MFRRSPALADDRSGLEITYWESRDEELLKAGLPAMLRRFPMLVTA
                     AVRLAWRASRADTAVALGGNLAAGVFTAFGLLATSDVLASLFAAGPTPGRVRAALPALA
                     LVGAAAALRGALLAAAGWAQARLKPQVERQAETRLFELTTRVELTAFDDHEFHNAMRRA
                     RDNGVPDTATVVEMTVSALTGAVGLAAPAVALGLLHPVLMPLLLVTAVPAGWAALRTAR
                     LRYAAFYRLSAARRRKFMLSDLMAERQPAAEVRAFTLRGFLLGEYDRVAELEQRVQLDV
                     ARRQTGAKAAGDLLTGAATVAVYAALGGLLAGGVIPLSVAGAAVLAIRAGQSSLAACVL
                     SLNKLYEAGLYFGDYLNFRALAAERLPPPDGAAPPAGDFRRVTAEGVTFRYPGAATPAL
                     TDVSVTVRRGEVIALVGENGSGKTTLAKLLAGLYRPDSGTIRWDDADLAGLDGDALRRR
                     VAVIAQDHTRWPLTVRENIVMGRPLDEDRLATAAAAAGADRVVEELPDGYDALLDRRFR
                     GGHDLSGGQWQRVAAARGFYRDAALVIFDEPTSALDARAEHALFERIRRHADGRTVVLI
                     THRLASVRFADRIYVLDRGRVAESGGHADLLAADGLYAELYRLQASAFQPDPQEVA"
     misc_feature    9575..9595
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.93"
                     /tool="antismash"
     misc_feature    complement(9586..9601)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            9731..9901
                     /locus_tag="ACTIVE_RS36655"
                     /old_locus_tag="ACTIVE_7355"
     CDS             9731..9901
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS36655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7355"
                     /product="hypothetical protein"
                     /protein_id="WP_173099271.1"
                     /transl_table=11
                     /translation="MSVLALEPRDAGVIDPEDLDVDFEMELLELLHGPQACVNTCKRTV
                     CSSYPCCPSIV"
     gene            10001..12538
                     /gene="lanL"
                     /locus_tag="ACTIVE_RS36660"
                     /old_locus_tag="ACTIVE_7356"
     CDS             10001..12538
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="ACTIVE_RS36660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7356"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_173099272.1"
                     /sec_met_domain="Pkinase (E-value: 1.2e-17, bitscore: 63.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.9e-16, bitscore:
                     57.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESSISGLISAIAREHGREIRSDDTWISVRDPGFAMPRQGWKLHV
                     SARPGTFAETLERILPLLLATPCDFKAARSAEMLRELNSGDLDAASVGKAVTVYPPQDD
                     VVRLGHALADALAGMAGPRVVSDRRVRPDAPVHYRYAPFVPQYKVDDNGDFELVVVGPD
                     GTAEPGAAGVEFSCPPWAADPFRPPAPEGGTAPAAPAAPSATSTEAPRVRTIGGRYRVT
                     TGVMRGPRGNVYRAEDPAGRPVVVKEARAYVGEHPEGYDLRMYLRNELRILTVLAGAGG
                     VPEALDHFRHGEDEFLVMSDAGATDLNRHVAEHGALTGPELSDLASRLLAVLDAVHARG
                     VVVRDLSPKNVVLGEDGGCTLIDFGTSRHGDLQMPGWSRGFSVPDQRTGRPSEPSDDLF
                     SLGATLFFAATGMNPVIIDPDPERGVERTLQCLARTSPGDGVVALVPRLLSLDPAVRTS
                     AAAEIRAGRHATAKAAAPVPVPRLTGDLLSSVLTHTVRECVRFAERLMDEPPDHRTSPP
                     VTNVYAGSAGVGTELLRHPEGKAAGTDLARWTAGNLPDANLPASLYFGLTGTAVFLAAA
                     GVAMPRPVRMSGGERADQAHGVAGIGTGHLLLDALAPDPANVEMAAECARRLLAGDVAA
                     PDAAVTVEQPGSGVAVDTAFAHGDAGVADFLLAYHRATGDEAAGAAARDAFAALAARAA
                     ALVGELGGPAARPMGASWCQGMSGVVGALLRAARAYDDAHYLDLAERGARACLAIAPRA
                     WVSSQCCGLAGMGEALIDVALATGDDAYWRGAEEIVELMLVRSGGEPARPVFPGNDLDT
                     QAFTWGTGTAGILSFLRRLDARSGPRLWASPAV"
     gene            complement(12552..13106)
                     /locus_tag="ACTIVE_RS36665"
                     /old_locus_tag="ACTIVE_7357"
     CDS             complement(12552..13106)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658382.1"
                     /locus_tag="ACTIVE_RS36665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7357"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_246342405.1"
                     /transl_table=11
                     /translation="MSRPPAASIPHHRLPRLEKHPMQPVTVRDARPHEYDLIGELTVEV
                     YVHGGLVSPESSYVGKLRDAADRAAKSQLLVAEIASEIAGAVAYCPPGSPYAELAAPDE
                     AEFRMLAVLAKARRSGAGRALVAECAARARAAGLTGLRLSTQANMEAAHRMYERLGFVR
                     TPDRDWSPVPGLRLLTYSLTF"
     gene            13256..14923
                     /locus_tag="ACTIVE_RS36670"
                     /old_locus_tag="ACTIVE_7358"
     CDS             13256..14923
                     /GO_function="GO:0016702 - oxidoreductase activity, acting
                     on single donors with incorporation of molecular oxygen,
                     incorporation of two atoms of oxygen [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854017.1"
                     /locus_tag="ACTIVE_RS36670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7358"
                     /product="carotenoid oxygenase family protein"
                     /protein_id="WP_173099273.1"
                     /transl_table=11
                     /translation="MPVPRSILGTQDVGDLELQVVAGAWPDDVRGHFVVSTSDQRTHPV
                     HAFFGDGIIARLPLRPDADGRFRWRARVIDTPSVRLRRRRPDLFTAGPVGTSSPWGFVN
                     AANTAPLPWGDRLFATWDAGRPVEVDPVTLEFVAEVGHRDDWKPAIDQAVLPLISTSAH
                     PVIDPERGCLWTVSRDVMTGTVSVIRYAGKGSRVERWEVADAVLPQATHTITQTRDWLV
                     LADTAYKIDTDEVFGAERTVANNPDGPVLLIRKDDLRPGGGTVACTEFRIAPEVNHFYA
                     KYDDSDGVQVVMEHTPGVDIGMYLREDDLDAFGRPVDPALRGMYCHGMTPALTTVLLFD
                     PETGRVSERARARDPERWWQAELSAIDWSIEGQTAPTRHHLVYLGFHPEAINQRALRNY
                     TGRIDADLFPPEETPAVLVSHDRDDLKPLAEWTFALDDYPTSPSFVPRGRGGTRYAGTD
                     PGGHDGYLVVAVHNDDRFRVELFDAADVGRGPLAVLAPPPGTTVPFLIHSAWMPEAVPA
                     PELERLGFADDLDDRLDQLAPDLRAITREVAAELAAGR"
     gene            complement(14952..15698)
                     /locus_tag="ACTIVE_RS36675"
                     /old_locus_tag="ACTIVE_7359"
     CDS             complement(14952..15698)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS36675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7359"
                     /product="hypothetical protein"
                     /protein_id="WP_173099274.1"
                     /transl_table=11
                     /translation="MIVALACAGTLTACGDASGVAKPPHTLEPGGSTATPAKDSPHGEH
                     LVLRMRKRGGMAGLGGPGALPDFSLYSTGRAVTASQGKPTEYRLKPAAVNRLLADARAA
                     GLGRSHTVGPGNVSDAFILEFTMGGAHSSIAQPGSRPDPAPAFQKRLDPSTWATSDVAS
                     GPAPFKPSKVAVLASQGAVADGPVKTWPLAPLGQGARVGAAVCTVASPAKVPATSPNTA
                     WRSGGATYTVRVRPLLPDEHSCADLR"
     gene            15841..16566
                     /gene="bioD"
                     /locus_tag="ACTIVE_RS36680"
                     /old_locus_tag="ACTIVE_7360"
     CDS             15841..16566
                     /EC_number="6.3.3.3"
                     /GO_function="GO:0004141 - dethiobiotin synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009102 - biotin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bioD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633238.1"
                     /locus_tag="ACTIVE_RS36680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7360"
                     /product="dethiobiotin synthase"
                     /protein_id="WP_173099275.1"
                     /transl_table=11
                     /translation="MSVLVVTGTCTGVGKTVVTAALAAVAAARGASVAVVKPGQTGMAG
                     GEPGDLDEVRRLAGVEDVHEAARFPDPLSPAAAARRAGVPPVRLPDVAKHVQELAATRR
                     LVLVEGAGGLLVRYDEEGTTIADLARWLGAAVVVATRPDLGTLNHTALTLEAMAHRGVQ
                     LAGVVIGSWPDEPDLAMRSNIRDLETIAARPLSGALPAGASALDPAEFLVAAHRGLAPA
                     FGGSFDPAAFREAHAPEAQ"
     gene            complement(16608..17342)
                     /locus_tag="ACTIVE_RS36685"
                     /old_locus_tag="ACTIVE_7361"
     CDS             complement(16608..17342)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633235.1"
                     /locus_tag="ACTIVE_RS36685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7361"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_173101664.1"
                     /transl_table=11
                     /translation="MGKHHTNQAPRIPKYYKLKELLVELIQSLPPGSPLPPERALAEKY
                     ETSRTTVRQALAELVVEGRLQRIQGKGTFVAKPKVSQELQLVSYTEDMRHHGLRPETRI
                     LDAGYVSADERLAALLCIRPGGRVLRVHRLRLADGEPMSIDTSHLPARRFPGLRRELPR
                     HRSLYETLATAYDVHLTEAEETIETVLATPHDAQLLGVDVGLPMLLLSRHAFDTTGQPV
                     EWAQSLYRGDRYKFITRLRRDT"
     misc_feature    17362..17377
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            complement(17455..18621)
                     /locus_tag="ACTIVE_RS36690"
                     /old_locus_tag="ACTIVE_7362"
     CDS             complement(17455..18621)
                     /EC_number="2.3.1.47"
                     /GO_function="GO:0008710 - 8-amino-7-oxononanoate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009102 - biotin biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (36-374). E-value:
                     3.4e-53. Score: 173.0. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS36690_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109: 8-amino-7-oxononanoate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633234.1"
                     /locus_tag="ACTIVE_RS36690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7362"
                     /product="8-amino-7-oxononanoate synthase"
                     /protein_id="WP_173099276.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.3e-51, bitscore:
                     172.9, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.3e-09,
                     bitscore: 34.2, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 4.8e-05, bitscore:
                     21.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDDPLARFRAAADRRAEAGLRRTLRPRDAAHGGLADLASNDYLG
                     LSRDPRLVDGAVAAARAWGTGSSGSRLVTGTTALHAELDRRLAAFTGSAAGLVFSSGFL
                     ANLGAVTALSGPGTLVVSDQLNHASIVDACRLSRARVVIVPHRDPAAVEQALAERDEDH
                     AIVVTDAVFSVDGDLAPLADLHRAARAHGALLVIDEAHALGVVGDGGRGAAHAAGLAGE
                     PDVVLTLTLSKSLAAQGGAVLGAPEVVQALLDTGRAFIFDTGLNPPAVGAALAALDVLE
                     ADPGLPARARATARAMANLAAGSGLETADPAAAVVPVFLGEPDDALRAAAICAEHGLRV
                     GCFRPPSVPKGRACLRLTARATVDESDLTRLRAALAEIAGSTGRSLHA"
     aSDomain        complement(17500..18513)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS36690_Aminotran_1_2.1"
                     /evalue="3.40E-53"
                     /label="ACTIVE_RS36690_Aminotran_1_2.1"
                     /locus_tag="ACTIVE_RS36690"
                     /protein_end="374"
                     /protein_start="36"
                     /score="173.0"
                     /tool="antismash"
                     /translation="DLASNDYLGLSRDPRLVDGAVAAARAWGTGSSGSRLVTGTTALHA
                     ELDRRLAAFTGSAAGLVFSSGFLANLGAVTALSGPGTLVVSDQLNHASIVDACRLSRAR
                     VVIVPHRDPAAVEQALAERDEDHAIVVTDAVFSVDGDLAPLADLHRAARAHGALLVIDE
                     AHALGVVGDGGRGAAHAAGLAGEPDVVLTLTLSKSLAAQGGAVLGAPEVVQALLDTGRA
                     FIFDTGLNPPAVGAALAALDVLEADPGLPARARATARAMANLAAGSGLETADPAAAVVP
                     VFLGEPDDALRAAAICAEHGLRVGCFRPPSVPKGRACLRLTARATVDESDLTRLRAA"
     misc_feature    complement(18689..18707)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.81"
                     /tool="antismash"
     gene            18695..20377
                     /locus_tag="ACTIVE_RS36695"
                     /old_locus_tag="ACTIVE_7363"
     CDS             18695..20377
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658374.1"
                     /locus_tag="ACTIVE_RS36695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7363"
                     /product="PAS domain-containing sensor histidine kinase"
                     /protein_id="WP_173099277.1"
                     /transl_table=11
                     /translation="MPTLTDLVRDHTDLTETDVEWLHALVSDWQLLADLSFADLLLWVP
                     LRSGAAVPADGPGARGGRRGGGTIDTGAAVQGWVAIAQMRPTTGPTAYPEDLVGKVVRT
                     GRRGLIDVAWRERRIVREGDPEWGSGIPVREESIPVRRGAKVLGVIQRSTNLSSARTPS
                     RLELTYLQSASDLAKMISEGRFPVPGEEPNMVRSPRVGDGLMRLDRGGSVTYASPNAQS
                     AYRRLGLPSDLAGESLGKVTAALCDTGEPLEEALSVVLSGRAPREVEVEAHGSVMQLRT
                     IPLVVGGTRIGAIVLCRDVTELRWRDRELMTKDATIREIHHRVKNNLQTVAALLRLQAR
                     RLQVPEGRAALDEAVRRVGSIAIVHETLSHTPDELIDFDDIADRVIMMAGEVSTPETKV
                     APKRTGSFGVLPAEIATPLAMALTELLQNALEHGLTNRFGTLEVVAHRYGEGTPPREPE
                     GVPVWGEWPGSDAHDPRAHKEPSAARPAATGPRLVAVVADDGVGLPADFDVESSNSLGL
                     QIVRTLIVGELGGSLDFRDRPGGGTEVIVDVPLDHTNRPPGHR"
     gene            complement(20562..20822)
                     /locus_tag="ACTIVE_RS36700"
                     /old_locus_tag="ACTIVE_7364"
     CDS             complement(20562..20822)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633232.1"
                     /locus_tag="ACTIVE_RS36700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7364"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_151541468.1"
                     /transl_table=11
                     /translation="MDWRHRAACRDVDPELFFPIGNTGPAILQIEEAKQVCRRCDVTDA
                     CLRWALESGQDSGVWGGMGEDERRALKRRASRARARANAGL"
     misc_feature    complement(20865..20880)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(20866..20877)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.18"
                     /tool="antismash"
     misc_feature    20875..20889
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.71"
                     /tool="antismash"
     gene            complement(21118..22059)
                     /locus_tag="ACTIVE_RS36705"
                     /old_locus_tag="ACTIVE_7365"
     CDS             complement(21118..22059)
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633231.1"
                     /locus_tag="ACTIVE_RS36705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7365"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_173099278.1"
                     /transl_table=11
                     /translation="MRAMLIANPKATSTSRRARDILVRAFTGDLDLEIAETAHRGHATE
                     LARRAAVEGYDAVIALGGDGTVNETVNGLLADGPSADLPALAVLPSGSANVFARALGLP
                     NDPVGATKAVLEALRAGRYRTVGLGAACLPDGVQRYFTFNAGVGLDAEVVREVERRRGA
                     GAKADPSLYVRAAVRHFFTGTDRRHPALTLEVPGRPPKAGLFLAFVSNTAPWTFAGRLP
                     VNPSPKSNFSRGLDVFGMRTMAAGPILGALAQMMLVRTRPVQGRHVLNVHDATEVTLRA
                     DRPIAFQLDGDYLGEQRSVTFRSVPKAVRILI"
ORIGIN
        1 gacgccgagg atctcgtaca ggagaccttc gccaaggcgt tcgcgtcctt ccaccagttc
       61 aaggaaggca ccaacctcaa ggcgtggctg taccgcatcc tgaccaacac gttcatcaac
      121 tcctaccgca aacggcagcg ccagccgcag cagtccgcgg ccgaggagat cgaggactgg
      181 cagctcgcgc gcgccgagtc gcacacctcc agcggcctga agtccgccga ggcggaggcg
      241 ctggagcacc tgcccgactc cgacgtgaag cgggcgctgc aggagctgcc cgaggagttc
      301 cgcatcgccg tctacctcgc cgacgtcgag ggcttcgcct acaaggagat cgccgacatc
      361 atgggcacgc ccatcggcac ggtgatgtcg cggctgcacc ggggacggcg gcagctgcgc
      421 gggatgctcg aggactacgc tcaggaccgc ggcctgacgc gcgccaccgg ggggccggca
      481 tgagccgggg acgcgccgga cgcgcagcac ggagcgacat gccggacacc gcggccgggc
      541 gcggcgcggt gagcgagagg ggtgcgtgag ccatgagctg tggcgaccac cacgagacgt
      601 cctgcgaaga ggtcctcgcg cgcgtctaca gctaccttga cggcgaactc gaccagggcg
      661 gctgcggcga ggtgcgcgag cacctcgacg agtgcgggcc ctgcctgcgc gagtacggcc
      721 tggaagaggc cgtcaagaag atcgtgaaca agtcctgcgg atgcgagcag gcgccggccg
      781 agctgcgctc caaggtgctc ggccggatcg aggagatctg cggcgagatc aaggcgaccg
      841 gcggcggcgt cgcggccggc ggcaccggcg cgtccgagtc cgcctgaccg ccgggtccgc
      901 ccggccgcag gagcccgcgc acgaccggcg ggcccggccg aggcgcgcgt ccgcgtgacg
      961 ccggccctcg catgtccggg gccggacggc gcgggcgccg gtcggcgggg ccccggctgg
     1021 gtatcgtgct ggggtgctcg ctctcgtcac cggcgcggcc ggcttcatcg ggtcccatct
     1081 cgtcgaccgg ctcctcgccg acggccacga ggtcgtcggc gtggacgacc tgtcgtcggg
     1141 cgccaaccag aacccggcca tcgagctgtg gcggatggac gtggccgatc cggcgctcgc
     1201 cgagcggatg gcggcgcgcc gtcccgaggt cgtctgccat ctggcggcgc aggtgagcgt
     1261 gcgcgcgagc gtggccgacc cgctgcacga cgcgcgggtg aacgtgacgg gcaccgcgaa
     1321 cgtgctggag gcggcgcggg cggcgggcag ccgcaaggtc gtcttcacct ccagctgcgc
     1381 ggtgtacggg gtgccggacg cgctgcccgt cccgccggac gcgccgctgc gtcccgcgtc
     1441 gccgtacgcg gcgtccaagg tgtcgggcga ggtctacgcc gggatgtacc gggcgctgca
     1501 cggcctcgac ttcacgacgc tgacgctggc gaacgtgtac gggccgcggc agacgccgga
     1561 gggcgaggcc ggcgtgatct cgatcttcac cgacgcgctg ctggcgggcc gcccgacgac
     1621 ggtgttcggc gacggcaagc agacgcgcga ctacgtgtac gtcctggacg tcgtggacgc
     1681 cttcgcgcgg gccgcgggcg aggcgggcgg cggcggacgg ttcaacgtcg gcacgggcct
     1741 gcagacgacc gaccgggacc tgcacgcgct cgtggccgcc gcggtgggcg caccggacga
     1801 gccggagttc gcgccgccgc gcctcggcga cctgccggcg atggcggtgg acccggggcc
     1861 gacgcgggag gcgctcggct gggagccgcg ggtgagcctc gtcgacggtc tcgccgagac
     1921 ggccgcgtgg gcgcgcgggc gcaccgcctg agcgcacccg cctgagcgca ccgcgcgggc
     1981 cgagggccgg ttccgtgccg gagagccgag gaatgcggct tggtgccatt gatgggttga
     2041 ttctgcccgg tttaggaatg ccatttgcgg atgcacgtgc attgagattg tgcagcggca
     2101 ttgtgcgggt acgctcagtg cattatcccc ggcaattgat cacttaaagt gacccttgct
     2161 tcacgctttg ctcacgattc ccgccatgcc tgtgtgacct gggcagttcg cgttaggctt
     2221 gggccgaaat cagcgacggg aacgcgtgca tgcccgggaa ttcggggtat gtggggacct
     2281 ggagatcggg gccgtgcggt tccggtgagc cggccgcgag gccggcgggc ccggtcaacg
     2341 gggggaggcg gaagccatgc tcaagtgcga gagtccggcc ggacgcggcc ggtgccaggg
     2401 cgccacggtg tcgtcgtcgc tgatgatgcc cgagggcgtt tcctgggtct gaggtgccgg
     2461 caggcacggt cgatcccggc ggcggcccgc tcgttcgtca ctccctaagg ggcggcaatg
     2521 cgtggactac ctctcgctgc ctgggcgtac gtgtgcgggg tggtcgcgct cgcggccgcg
     2581 ctgatcgcca cgtcgtcctt cacgggggtg gactggacga agctggccgt gctggccctg
     2641 ctcttcctga tctgcgactc ggcgcccgcc cggctgaacg tcgagcgggc ccgcgtctcg
     2701 ctgagcttcg ccgccagcct ggcgggggtc gtgctcctcg gcccggccgg cgcggcgctc
     2761 ctcgggctca gcgcgctggt caccgggcag cggttcttcg cgcccgagaa gcgcgccttc
     2821 aacggcgcgc agttcgcgct cagcggcttc tgcgccggca cggtcttcga cctgctcggc
     2881 ggtgaccgct tccaccccga gcagtcccgc tgggtggaga acgtgatcgg cccgttcctc
     2941 ggcgccctgg tcaccttcgt cctggtcaac ctgctgctga tggccggggt gctgctgctg
     3001 tcccggcagg ccgcgccgcg cgagctgctg cacgagagcg gccagctcgc cgtcggctgc
     3061 ctcggctacg gcatggtcgg gctgctgatc gccgggctgt ggccgcggat cggcgccttc
     3121 gccgccgtgc tggtgctgct gccgctgttc atcgcccgct gggcgatgga ccaggcgtac
     3181 gcgcagcagc aggcgcacgc cgccaccctc gccgcgctct gccaggccgt cgagaccaag
     3241 gactactaca cccgcggcca ctccgagcgg gtctcccgcg gctcggtgat gatcgcgcag
     3301 gagatcggca tgcgcgccga ccgggtcgag gcgatccggt acgcggggat gctgcacgac
     3361 gtcggcaagc tcggcgtccc gacgaaggtg ctgcagaagt ccggctcgct caccgaggag
     3421 gagttcgccg cgatccagct gcacccgatg cgcgggctgg agatcgtccg ggagatcggc
     3481 ttcctggacg aggcgctcgc cgggatcatg caccaccacg agaaggtgaa cggccgcggc
     3541 tacccgatgg gcctggccgg cgacgagatc cccgagttcg cccgggtgat ctccgtcgcg
     3601 gacgcgttcg actcgatgac ctccacccgc tcctaccggg ccgcccgcac cgtggcggag
     3661 gccgtggcgg aactgcgccg cggcatgggc gaccacttcg acccggtgat ggtggaggcg
     3721 ttcctgcgcg cgctggaccg ggacggctgg gagccgccgc ggcccgtcgt gctgccggac
     3781 gacgacgtcg tcgagaccac ccagcaggac catgacgacc cgagcgcccc gctgcgggtc
     3841 gccggagacg aagcacggcg gtgaccggac cccccatgag cagcacccag atccgggccc
     3901 gccgcgagcg ggccgcatgg cagaccatcg actccggcca gctgctgctg atcgcgaccg
     3961 ccgggctgtt cgtcgtcgtc gcgatcgccg aggtggccgc ggccgggctc cggcaggcca
     4021 acgtcgcgat catcttcggc gtgctgatcg cgctcggcga gctgttccgg atggtgatgc
     4081 cgggcaaccg cgaggtcgcg ccgatcgcca gcgccggcgc gatgggctac gcgctgctgg
     4141 tcggcatcgg ccccgagggc gccccgccgg acgcgccgct cggcgtcgtc cccgccgagc
     4201 actcgccgct gcaggtcgtc gcggtgacgt cggtcgggat gctggtcggc tcgctgccgc
     4261 acatcctggt cggccggtcg ccgcggccgg acgcgatggc gcgccggctg ttcaccgtcg
     4321 cggtcgtggc gctgtgcttc cggccgatgc tgtcgctcgg gctgccctgg cagctgctgc
     4381 tggcggtgat gggcctggtc gtcgtgctgt cctgcttcac cgacgtgctg atcgccgcga
     4441 tgatccgggc ggaggcggtg cgggcccggt tcgggatcgc gctgcgcgac gagatcgacg
     4501 cgaagatggc gctgtgcgcg gcgaccagcg ccaccgcgat gctgatcgcg gtcgcgacca
     4561 ccgcgatggg cgaggccgcg ctgctgatct tcacggtgcc gatcctcgtc acccagttcg
     4621 cgttccgccg gtacgcgggg atccgcgcga cgtacctgca gaccgtccgg gcgctgtcgc
     4681 gggtcaccga ggtcggcggg tacgtcgaga ccgggcactc gcggcgggtg tcgcggctgt
     4741 cggtcgcgat gggccgcgag ctcggcatgt ccgaggagga gctgctcgag ctggagtacg
     4801 cggcgctgat gcacgacatc gggcagctgt cgctcggcga cccgatcccc ggcggcgcga
     4861 ccgtgctcgc ctcgcccgcc gagcagcgcc gcatcgccga gctgggcgcc gaggtcatca
     4921 agcagaccgg cgtgctggac cgggtcgcgc acatcgtcca gctgtcgtcg cacccgtacc
     4981 ggacgggccc ggagacgctc gcggggcccg gggaggcggg gcagccggtc ccggcgccgc
     5041 cgctggccgg ccgcatcatc aaggtcgcca acgcctacga cgacctggtg ggcgactccg
     5101 ccgaccggga ccgcggcgcc gccgtgttgg agcggctgcg gctggactcc gccgccgagt
     5161 acgacccgac ggtcgtggag gcgctcagcc gcgtcgtcga ccgccgtccc cgcccctgac
     5221 cgcgccctgg ccgcgcctct gagcgcgctc cggccgcggg ccgcggccgg gtttgtgggc
     5281 ggtaccgcgg gaccgggggc ggcgcgggca ctagtgtcgg cctggtcagg gccgccgggg
     5341 cagccggcgg accgcagcgc gccgagggag tccgcaggtg ttcgagtccg tgctggtggc
     5401 gaaccggggt gagatcgccg gccgggtcgt gcgcaccgcg caggccatgg gcctgaaggc
     5461 gatcgccgtg tactccgagg ccgacgccgg cctgccctac gtcgccgagg cggacgaggc
     5521 ggtgctgatc ggcccggccg acccggcgcg cagctacctc aacgcggcgg cggtgctgga
     5581 ggccgcgcag cgcacgaacg cgcaggccgt ccacccgggc tacgggttcc tcgcggagag
     5641 cgccccgttc gcgcgggccg tcgccgcgcg ggacctggtc tgggtcggcc cgccgccgct
     5701 ggtcgtcgcc cggatgggcg acaagatcaa cgcccggaac ctgatgaagg aggcgggcgt
     5761 gccggtctcg ccgggcgcgt gggagcccgt ccgggacgcc gcgaccgcgg tggaggaggc
     5821 cgagcggatc ggctacccgg tgatggtgaa gcccgccgcc ggcgggggcg gcgccgggct
     5881 cggctccgcg tacgacgcgg agacgctgcg caccgcgttc gaggcggcgc acaccgccgc
     5941 gacgcggctg ttcgggcacg gcgacgtgct gctggagcgg tacgtggagg gcgtccggca
     6001 cgtcgaggtg cagatcctcg gcctggtgga cggcaccgtc gtggcgcttg gggagcggga
     6061 gtgctccgtc cagcggcggt accagaaggt cgccgaggag acgccgtcgc cgggcgtcgg
     6121 cgcggcgctg cgggagcgga tgctcgccgc ggcggtccgc gcgggcgagg ccgtcgggta
     6181 ccggggcgtg gggacggtcg agttcctggt cgacccggtc gcgcaggagt tcttcttcct
     6241 ggagctgacg gcccggctgc agatcgagca ccccgtcacc gagatggtga ccggcgtcga
     6301 cctcgtcgag cagcagttcc ggatcgcggc cggcgagcag gtcgcgccgc ccgccgcgcc
     6361 gcgcggccac gcgatcgagt tccgcgtgca cgccgaggac ccgcagggct tccggccggg
     6421 ggccggggag atcaaggtgt gggaggagcc ggtcggcgac ggcatccgca tcgacgccgg
     6481 ctactacgag ggcaacaccg tcacgccgta ctacgactcg ctgctggcga agctctgcgt
     6541 gcacggcgac gaccgtgcgc acgcgctggc tcgcgcgcgc gccgcgctgg gcgcgttccg
     6601 catcgagggc atcgcgacga acctgccgtt cttcgcggag ctgctcgacc accgcgagtt
     6661 catcgacggc acgtacgact ccggcgtggt ggcgcgcatg cgcatccgct gacgggcctc
     6721 cccggggtca gccggccgga cgcgctccgg ccgagtccgc ccggtgcagg agggcgcgga
     6781 accgcggagg cgtgtccgcg ccgcccgccg ccaggacggt cccggcgtcg tcggtgacga
     6841 cgacgtacgg cggccacggg atgccgttgg cgtcgtacac gtcggggtcg gtcaccagcg
     6901 gcaggtcgcc gacgccgtgc tcgtccaggt gccgccggac gccgtcctcg tcggccgcgc
     6961 tcaccaggac cacccgccgt ccggacgcgg cctcggcgaa gaccggcagc atggtccggc
     7021 agaggccgca cgccggcgag atcagcgcga acaccgtcgg cgcctcgatc gcggagttca
     7081 gcgcgaacgg cgtcccgggc cgcgggcccg cgggcggcga cgcctccggc tcggcgaccc
     7141 cgggacgcgg ccggggcacc gccgcgaccg cgccgacgaa gaccgccgcg agcaccggct
     7201 gcagcggcga gaacggcgcg ggcccggcca ccgccgccat cacggccagc agcaggagca
     7261 gcgccgtccg cgtcaccgac gcggcgccga ccggtgccgg gcgccgcgcc gacccgaagc
     7321 agccgcagtc gatcaccatg ccgcgccgca gcaccgaggc catcgcgccg aggaacgccg
     7381 cgaacagcgc cgccgcggcc agcgcgcccc agcgccgggt ggcgggcacg gccagcagca
     7441 cggccgccgc cgcctcggcg gacagcaccg ccaccgccgc cgcgccggtc agccgggcgg
     7501 gcagcacacg gtaggcgccg atcgccgccg cgaacccgcg cacgtcgcgg accttgccgc
     7561 ccgccgcgac gagcagcacc gcgatcagcg ccggccacgc cgacgccagg acggtcacgc
     7621 gacctcctgc gggtccggct ggaacgccga cgcctggagc cggtacagct cggcgtacag
     7681 cccgtccgcc gcgagcaggt cggcgtgccc gccgctctcc gcgacgcggc cgcggtccag
     7741 cacgtagatg cggtcggcga agcggacgct ggccagccgg tgggtgatca gcaccaccgt
     7801 ccggccgtcc gcgtgccgcc ggatccgctc gaacagggcg tgctcggcgc gggcgtcgag
     7861 cgcggaggtc ggctcgtcga agatgaccag cgcggcgtcc cggtagaagc cgcgcgcggc
     7921 ggcgacccgc tgccactgcc cgcccgacag gtcgtggccg ccgcggaagc gccggtccag
     7981 cagcgcgtcg tacccgtccg gcagctcctc gaccacccgg tccgcgcccg ccgcggcggc
     8041 ggcggtggcg agccggtcct cgtcgagggg gcggcccatc acgatgttct cgcggacggt
     8101 gagcggccag cgcgtgtggt cctgggcgat caccgcgacg cggcggcgga gcgcgtcgcc
     8161 gtccaggccc gcgaggtcgg cgtcgtccca gcggatcgtc ccggagtccg gccggtacag
     8221 cccggcgagc agcttggcca gggtggtctt gcccgagccg ttctcgccga ccagggcgat
     8281 cacctcgccg cgccgcacgg tgacgctgac gtcggtgagc gccggcgtgg cggcgcccgg
     8341 gtaccggaac gtcacccctt cggcggtgac gcggcggaag tcgccggcgg gcggggcggc
     8401 gccgtccggc ggcggcagcc tttccgcggc gagcgcgcgg aagttcaggt agtcgccgaa
     8461 gtacaggccc gcctcgtaca gcttgttcag gctcagcacg cacgccgcca gcgacgactg
     8521 cccggccctg atcgccagca cggccgcgcc cgcgaccgac agcgggatca cgccgccggc
     8581 gagcagcccg ccgagcgcgg cgtagacggc cacggtcgcg gcgccggtga gcaggtcgcc
     8641 ggccgccttg gcgccggtct gccggcgcgc gacgtccagc tggacgcgct gctcgagctc
     8701 cgcgacccgg tcgtactcgc cgagcaggaa gccgcgcagg gtgaacgcgc ggacctcggc
     8761 ggcgggctgc cgctcggcca tcaggtccga cagcatgaac ttgcgccgcc gcgccgccga
     8821 cagccggtag aacgccgcgt accgcagccg cgcggtgcgc agcgcggccc agcccgcggg
     8881 cacggccgtg acgagcagca gcggcatcag cacggggtgc agcaggccga gcgcgacggc
     8941 gggcgccgcc agcccgaccg cgccggtcag cgcgctgacc gtcatctcga cgacggtggc
     9001 ggtgtccggc acgccgttgt cgcgggcccg gcgcatcgcg ttgtggaact cgtggtcgtc
     9061 gaacgcggtc agctcgaccc gggtggtcag ctcgaacagc cgcgtctccg cctgccgttc
     9121 gacctgcggc ttcagccggg cctgcgccca gccggcggcg gccagcagcg cgccgcgcag
     9181 cgccgccgcc gcgcccacca gcgccagcgc gggcagcgcg gcgcggaccc ggccgggcgt
     9241 cggcccggcc gcgaacagcg acgccagcac gtcggaggtg gccagcagcc cgaacgcggt
     9301 gaagaccccg gcggcgaggt tgccgccgag cgcgaccgcc gtgtccgccc ggctcgcccg
     9361 ccaggccagc cggaccgccg ccgtgaccag catcggaaac cgccgcagca tcgccggaag
     9421 gccggctttc agcagttcct cgtcgcggct ttcccaatag gtgatttcga gccccgacct
     9481 gtcgtcggcg agggccgggg agcgtcggaa cacagagcca acctagatca tcgattgtcg
     9541 gctgtaaatg cctcgttcca gggccgggtt cgccataccg tgccggtgac gaatgagtgt
     9601 ctggacagcc cgctgatcat ctgctcataa tgcgtccgtt tgctctgggg agcccggcag
     9661 cacccgatgc cggctctccg ggctcagatc ccgagcggcc gcccgaacgg cggtcaagga
     9721 aggagccccc atgtccgtgc tggccctgga gccccgcgac gccggcgtca tcgacccgga
     9781 agacctcgac gtggacttcg agatggaact gctggagctg ctgcacggcc cgcaggcctg
     9841 cgtgaacacc tgcaagcgca cggtgtgcag cagctacccg tgctgcccgt ccatcgtctg
     9901 accctctccg acgcacgcgg gaaaggccat tggctcccac cggtggcctc ttcctgcgcg
     9961 ttcgccattg ccggatacgg gccgcgaccg aagggcgaca atggagtcat cgatatccgg
    10021 gctcatttct gcgatcgccc gtgagcacgg ccgggaaatc cggtcggacg acacctggat
    10081 cagcgtgcgc gatcccggct tcgccatgcc ccggcagggg tggaaactgc atgtctccgc
    10141 gcggcccggc acgttcgcgg aaacgctcga acgcatcctg ccgctgctgc tggccactcc
    10201 gtgcgacttc aaggcggcgc gctccgccga gatgctgcgc gaactcaact ccggtgacct
    10261 cgacgcggcc tccgtcggga aggccgtcac cgtctacccg ccgcaggacg acgtcgtccg
    10321 gctcgggcac gcgctggccg acgccctcgc cggcatggcc gggccgcgcg tggtcagtga
    10381 ccgccgcgtc cgccccgacg cccccgtcca ctaccgctac gccccgttcg tgccgcagta
    10441 caaggtggac gacaacggcg acttcgagct ggtcgtcgtc ggcccggacg gcacggcgga
    10501 gcccggtgcg gcgggcgtcg agttcagctg cccgccgtgg gcggccgacc cgttccgccc
    10561 gcccgccccg gaaggcggca ccgcgcccgc cgcgcccgcc gcgccctcgg ccacgagcac
    10621 ggaggcgccg cgcgtccgga cgatcggcgg ccgctaccgg gtgaccaccg gggtgatgcg
    10681 cggcccgcgc ggcaacgtct accgggccga ggacccggcc gggcggcccg tcgtcgtcaa
    10741 ggaggcccgc gcctacgtcg gggagcatcc cgagggctac gacctgcgga tgtacctccg
    10801 caacgagctg cgcatcctaa ccgtcctcgc cggggccggc ggcgtcccgg aggcgctcga
    10861 ccacttccgg cacggcgagg acgagttcct cgtcatgagc gacgccggcg ccaccgacct
    10921 caaccggcac gtcgccgagc acggcgcgct caccggcccc gagctctcgg acctggcgtc
    10981 ccggctgctc gcggtcctcg acgcggtgca cgcccgcggc gtggtcgtcc gcgacctgtc
    11041 gcccaagaac gtggtgctcg gcgaggacgg cgggtgcacg ctcatcgact tcggcaccag
    11101 ccgccacggc gacctgcaga tgccgggctg gagccgcggc ttcagcgtgc ccgaccagcg
    11161 caccggccgc ccgtcggagc cgtccgacga cctgttctcg ctcggcgcga cgctgttctt
    11221 cgccgccacc ggcatgaacc ccgtcatcat cgaccccgac ccggagcgcg gcgtcgagcg
    11281 gacgctgcag tgcctggcgc ggacgtcgcc gggggacggc gtcgtcgcgc tcgtgccgcg
    11341 gctgctcagc ctcgacccgg ccgtccggac gagcgccgcc gccgagatcc gcgccgggcg
    11401 gcacgccacc gcgaaggccg cggcgccggt gcccgtcccg cgcctgaccg gcgacctgct
    11461 gtcgtccgtc ctcacgcaca cggtgcgcga gtgcgtccgg ttcgccgagc gcctcatgga
    11521 cgagccgccg gaccaccgga cgagcccgcc cgtcacgaac gtctacgccg gttcggcggg
    11581 cgtcgggacg gagctcctcc ggcatcccga gggcaaggcc gcgggcaccg acctcgcccg
    11641 ctggacggcc gggaacctgc ccgacgcgaa cctgcccgcc tcgctctact tcggcctcac
    11701 cggcacggcg gtcttcctgg ccgccgccgg ggtcgcgatg ccccggcccg tccggatgtc
    11761 cggcggcgag cgcgcggacc aggcgcacgg cgtcgccggc atcggcaccg gccacctcct
    11821 cctcgacgcc ctcgcccccg acccggccaa cgtggagatg gcggccgagt gcgcgaggcg
    11881 gctgctggcg ggcgacgtcg ccgcgccgga cgcggcggtg acggtcgagc agccggggtc
    11941 gggcgtcgcc gtcgacaccg cgttcgcgca cggcgacgcg ggcgtcgccg acttcctgct
    12001 ggcctaccac cgcgccaccg gcgacgaggc cgccggcgcc gcggcccgcg acgcgttcgc
    12061 cgcgctcgcc gcccgggcgg ccgcgctggt cggcgagctg ggcggcccgg ccgcgcgccc
    12121 gatgggcgcc tcgtggtgcc agggcatgtc cggcgtcgtc ggcgcgctgc tgcgcgccgc
    12181 ccgcgcctac gacgacgcgc actacctcga cctcgccgaa cggggcgccc gcgcctgcct
    12241 ggcgatcgcg ccgcgcgcgt gggtgtcgtc ccagtgctgc ggcctggcgg gcatggggga
    12301 ggcgctcatc gacgtcgccc tggccacggg cgacgacgcg tactggcggg gcgccgagga
    12361 gatcgtcgag ctgatgctcg tgcgcagcgg aggcgagccc gcgcggccgg tcttccccgg
    12421 caacgacctc gacacccagg cgttcacctg gggcaccggc accgcgggga tcctgtcgtt
    12481 cctgcgccgc ctggacgccc ggtccgggcc gcgcctctgg gcgtccccgg ccgtctagac
    12541 ggcgcgggcg tctagaacgt cagggagtag gtgagcaggc gcaggccggg cacgggggac
    12601 cagtcgcggt ccggggtgcg gacgaagccg agccgctcgt acatccggtg cgcggcctcc
    12661 atgttcgcct gcgtggacag ccgcagcccg gtcagcccgg cggcgcgggc gcgcgccgcg
    12721 cactcggcga ccagggcgcg tcccgcgccg gaccgccggg ccttcgccag gacggcgagc
    12781 atgcggaact cggcctcgtc cggggccgcc agctcggcgt acgggctccc gggcgggcag
    12841 taggcgaccg cgcccgcgat ctcgctggcg atctcggcga cgagcagctg cgacttggcg
    12901 gcccggtcgg cggcgtcgcg gagcttgccg acgtaggacg actcgggcga gacgagcccg
    12961 ccgtgcacgt acacctcgac ggtcagctcg ccgatcaggt cgtactcgtg ggggcgcgcg
    13021 tcgcggacgg tgacgggctg catcgggtgc ttctccaggc gggggagccg gtggtgcggg
    13081 atcgacgcgg ccggaggccg cgacatatca ggctatccgc ccacgggacg ggcgggcgac
    13141 cggcggcccg cccgcgcgcg agccgttagt cgttagcggc ttgacgacta gcgtcggggg
    13201 cgtgttgatt ggcgggaggc aacgggcggc agcccgccgg accccaggag gcgccatgcc
    13261 ggtcccccgc tcgatcctcg gcacgcagga cgtcggcgac ctggagctgc aggtcgtcgc
    13321 cggcgcgtgg ccggacgacg tccgcggcca cttcgtcgtc agcacctccg accagcgcac
    13381 ccaccccgtg cacgcgttct tcggcgacgg gatcatcgcg cggctgccgc tgcggccgga
    13441 cgcggacggc cggttccgct ggcgcgcccg ggtgatcgat accccgtccg tccggctgcg
    13501 ccgccggcgc cccgacctgt tcaccgccgg acccgtcggg accagctcgc cgtgggggtt
    13561 cgtgaacgcc gccaacacgg cgccgctgcc gtggggcgac cggctgttcg ccacctggga
    13621 cgccgggcgg cccgtcgagg tcgacccggt cacgctggag ttcgtcgccg aggtcgggca
    13681 ccgcgacgac tggaagcccg cgatcgacca ggccgtgctg ccgctgatct ccacgtccgc
    13741 gcacccggtg atcgaccccg agcgcggctg cctgtggacg gtcagccgcg acgtcatgac
    13801 cggcacggtg tcggtgatcc ggtacgcggg gaaggggagc cgggtcgagc gctgggaggt
    13861 ggcggacgcc gtcctgccgc aggccacgca caccatcacc cagacccgcg actggctcgt
    13921 cctcgccgac accgcctaca agatcgacac cgacgaggtg ttcggcgcgg agcggaccgt
    13981 cgccaacaac cccgacgggc cagtcctgct gatccgcaag gacgacctgc gccccggcgg
    14041 cggcaccgtc gcctgcacgg agttccggat cgcgcccgag gtcaaccact tctacgccaa
    14101 gtacgacgac tcggacggcg tccaggtcgt catggagcac acgcccggcg tcgacatcgg
    14161 catgtacctg cgcgaggacg acctcgacgc gttcggccgc cccgtcgacc cggcgctgcg
    14221 cggcatgtac tgccacggca tgacgcccgc gctcaccacc gtcctgctgt tcgacccgga
    14281 gaccgggcgg gtgagcgagc gggcccgcgc ccgcgacccg gagcgctggt ggcaggcgga
    14341 gctgtcggcc atcgactgga gcatcgaggg gcagaccgcc ccgacccggc accacctcgt
    14401 ctacctcggc ttccaccccg aggcgatcaa ccagcgggcg ctgcggaact acaccggccg
    14461 catcgacgcc gacctgttcc cgccggagga gacccccgcc gtcctggtca gccacgaccg
    14521 cgacgacctg aaaccgctcg ccgagtggac cttcgcgctg gacgactacc cgacgtcgcc
    14581 gtcgttcgtg ccgcgcgggc ggggcggcac ccggtacgcg gggaccgacc cgggcgggca
    14641 cgacggctac ctcgtcgtcg ccgtccacaa cgacgaccgg ttccgcgtcg agctgttcga
    14701 cgccgccgac gtcgggcgcg gcccgctcgc cgtgctggcg ccgccgcccg gcaccaccgt
    14761 cccgttcctc atccactccg cgtggatgcc ggaggccgtc cccgcgcccg agctggagcg
    14821 gctgggcttc gccgacgacc tcgacgaccg cctcgaccag ctcgcccccg acctgcgggc
    14881 gatcacccgc gaggtcgccg ccgaactcgc cgccggacgc tgaccggcgg cgtgccgccg
    14941 gtgaacgcgg gtcagcggag gtcggcgcag gagtgctcgt cggggaggag gggacgcacg
    15001 cggacggtgt aggtcgcgcc gccgctgcgc caggcggtgt tcgggctggt cgccgggacc
    15061 ttcgcgggcg aggccaccgt gcacacggcc gctccgaccc gcgcgccctg accgagcggc
    15121 gccagcggcc acgtcttgac cgggccgtcg gccaccgcgc cctgcgacgc gagcaccgcc
    15181 accttcgacg gcttgaacgg ggccggcccc gacgccacgt ccgacgtcgc ccaagtgctc
    15241 gggtccagcc gcttctggaa cgccggcgcg gggtcaggcc gtgaccccgg ctgggcgatg
    15301 ctgctgtgcg cgccgcccat ggtgaactcc aggatgaacg cgtcggagac gttgcccggc
    15361 ccgaccgtgt gcgagcggcc gaggcccgcg gcgcgcgcgt cggccagcag gcggttcacc
    15421 gccgccggct tcaaccggta ctcggtcggc tttccctggg acgcggtgac ggcgcggccc
    15481 gtcgagtaca gcgagaagtc gggcagggcg cccgggccgc ccagcccggc catgccgccc
    15541 ctcttgcgca tccgcaggac gaggtgctcg ccgtgcggcg aatccttcgc gggggtcgcc
    15601 gtggacccgc cgggctccag cgtgtgcggc ggcttcgcga cgccggacgc gtcgccgcag
    15661 gccgtcagcg tgcccgcgca cgcgagcgcg acgatcaagc tggtgcgagt gtgcgaaccg
    15721 gccatgagcc ttggacgccc cgccgcgccg cccggttccc ccgcgataca aattccgcgc
    15781 cggaagactg tgggaatctg cgaccgacca ggccctgctc cccgcgctaa tgtgccgggc
    15841 gtgagcgtgc tcgtagtgac cggaacctgt acgggcgtcg gcaagaccgt cgtcaccgcg
    15901 gcgctggccg ccgtcgccgc cgcgcgcggc gcgtcggtcg ccgtggtcaa gcccggccag
    15961 accgggatgg ccggcggcga gcccggcgac ctcgacgagg tgcggcggct cgccggcgtc
    16021 gaggacgtgc acgaggccgc gcgcttcccc gacccgctgt cgcccgccgc cgcggcccgc
    16081 cgcgccggcg tcccgcccgt ccggctgccg gacgtcgcca agcacgtcca ggagctcgcc
    16141 gcgacccgcc ggctcgtgct cgtggagggc gcgggcgggc tgctcgtccg ctacgacgag
    16201 gagggcacca ccatcgccga cctggcgcgc tggctcggcg ccgcggtcgt cgtggcgacc
    16261 cgcccggacc tcggcacgct caaccacacc gcgctcacgc tggaggcgat ggcgcaccgc
    16321 ggcgtgcagc tcgcgggcgt ggtcatcggg tcctggccgg acgagccgga cctggcgatg
    16381 cgcagcaaca tccgcgacct ggagaccatc gcggcgcgcc cgctgtccgg cgcgctgccg
    16441 gccggcgcgt ccgcgctcga cccggccgag ttcctcgtcg ccgcgcaccg cggcctggcc
    16501 ccggcgttcg gcggctcctt cgaccccgcc gccttccgcg aggcccacgc ccccgaggcg
    16561 cagtagcgga tcggccggcc cccgcacccc acggcggctt cgccgggtca ggtgtcgcgg
    16621 cgcagccggg tgatgaactt gtaccggtcg ccgcggtaga gggactgcgc ccactcgacg
    16681 ggctggcccg tcgtgtcgaa cgcgtgccgg gacagcagca gcatcggcag gccgacgtcg
    16741 acgccgagca gctgcgcgtc gtgcggggtc gccagcaccg tctcgatcgt ctcctccgcc
    16801 tccgtcaaat ggacgtcgta ggcggtcgcg agggtctcgt acagggaccg gtgccggggc
    16861 agctcgcggc gcagccccgg gaagcggcgg gccggcaggt gcgaggtgtc gatcgacatc
    16921 ggctccccgt cggcgagccg gagccggtgg acgcgcagca cgcgcccgcc cggccggatg
    16981 cacagcagcg cggcgaggcg ctcgtcggcg ctgacgtagc cggcgtccag gatgcgggtc
    17041 tccggccgca gcccgtggtg ccgcatgtcc tcggtgtagg agacgagctg cagctcctgc
    17101 gacaccttcg gcttggcgac gaacgtgccc ttgccctgga tgcgctgcag gcgcccctcg
    17161 acgacgagct cggcgagagc ctgccgtacg gtggtccggg acgtctcgta cttctccgcc
    17221 agcgcccgct caggcggcag cgggctgccg ggcggcagcg actggatgag ctcgacgagg
    17281 agttctttga gcttgtagta cttcgggatg cgcggcgcct ggttggtgtg gtgcttgccc
    17341 aggtcgccga gcgccgcccg gtcgaatccg cgctcgaagc cgtccccgtg ccggggcccg
    17401 cccctgacct ccgtcacggc atctcctcac gttcatcatc ggtttccccc gatgttatgc
    17461 gtgaagacta cggccggtag agcccgcgat ctccgccagg gcggcccgca gccttgtgag
    17521 gtccgactcg tcgaccgtcg cccgcgcggt gagccgcagg caggcccggc ccttcgggac
    17581 ggacgggggc cggaagcagc cgacgcgcag cccgtgctca gcgcagatcg cggcggcgcg
    17641 cagcgcgtcg tcgggctcgc cgaggaacac cgggaccacc gcggcggccg gatcggcggt
    17701 ctccagtccg gaaccggccg cgaggttcgc catcgcgcgg gccgtggcac gcgcccgggc
    17761 cggcaggccg ggatcggcct ccaggacgtc gagggcggcg agcgcggcgc ccacggcggg
    17821 cgggttcagg ccggtgtcga agatgaacgc gcggccggtg tccagcagcg cctggaccac
    17881 ctccggggcg ccgaggacgg cgccgccctg cgcggccagc gacttcgaca gggtgagggt
    17941 gaggaccacg tcgggctcgc cggccagccc ggcggcgtgc gcggcgccgc gtccgccgtc
    18001 gccgacgaca ccgagcgcgt gcgcctcgtc gatcaccagc agcgccccgt gcgcccgcgc
    18061 cgcgcggtgc aggtccgcga gcggcgccag gtcgccgtcc acggagaaca ccgcgtcggt
    18121 gacgacgatc gcgtggtctt cgtcacgttc ggcgagggcc tgctcgacgg ccgccgggtc
    18181 ccggtgcggg acgatcacga cgcgggcccg cgacagccgg cacgcgtcca cgatcgaggc
    18241 gtggttgagc tggtccgaca ccaccagcgt gcccggcccg gacagcgccg tcacggcgcc
    18301 gaggttggcc aggaagccgg aggagaacac cagcccggcg gcgctgccgg tgaacgcggc
    18361 gagccgccgg tccagctcgg cgtgcagcgc ggtcgtgccg gtgaccagcc gggaccccga
    18421 cgacccggtg ccccaggcgc gggccgcggc gaccgcgccg tccaccagcc gcgggtcgcg
    18481 ggacaggccg aggtagtcgt tggacgcgag gtcggcgagg ccgccgtggg cggcgtcgcg
    18541 cgggcggagc gtccgccgca ggcccgcctc ggcgcgccgg tccgcggcgg cgcggaacct
    18601 ggcgaggggg tcgtcggtca tgtccgaatc ctgccaggtg gcgagggtcg gggacggcgg
    18661 cggggcacca gatccgatgg gcgatgattg tggtgtgcct accttgaccg atctggtccg
    18721 cgaccacacc gatctgaccg agaccgatgt ggagtggctg cacgcgctgg tgtcggactg
    18781 gcagctcctc gccgacctgt cgttcgccga cctgctgctg tgggtgccgc tgcggtccgg
    18841 cgcggcggtc cccgcggacg gcccgggcgc ccggggcggg cggcgcggcg gcggcacgat
    18901 cgacaccggc gccgccgtgc agggctgggt cgcgatcgcg cagatgcggc cgacgaccgg
    18961 ccccaccgcc taccccgagg acctggtcgg caaggtcgtc cggacgggcc gccgcgggct
    19021 gatcgacgtg gcgtggcggg agcggcggat cgtccgggag ggcgacccgg agtggggcag
    19081 cggcatcccc gtccgggagg agtcgatccc ggtgcgccgc ggcgcgaagg tcctcggggt
    19141 gatccagcgc agcaccaacc tcagctcggc gcgcaccccg tcccggctgg agctgaccta
    19201 cctgcagagc gccagcgacc tcgccaagat gatctccgag ggccggttcc ccgtgccggg
    19261 cgaggagccg aacatggtcc gctcgccgcg cgtcggcgac gggctgatgc ggctggaccg
    19321 gggcggctcg gtcacctacg ccagcccgaa cgcccagtcc gcctaccggc gcctcggcct
    19381 gccgtccgac ctggccggcg agtcgctcgg caaggtcacc gccgcgctgt gcgacaccgg
    19441 cgagccgctg gaggaggcgc tcagcgtcgt gctcagcggc cgcgccccgc gcgaggtgga
    19501 ggtcgaggcg cacggctcgg tcatgcagct gcggacgatc ccgctggtcg tcggcggcac
    19561 ccggatcggc gcgatcgtgc tgtgccggga cgtcaccgag ctgcgctggc gcgaccggga
    19621 gctgatgacc aaggacgcca ccatccggga gatccaccac cgggtgaaga acaatctgca
    19681 gaccgtcgcc gcgctgctgc ggctgcaggc ccgccggctg caggtcccgg aggggcgggc
    19741 ggcgctggac gaggcggtcc gccgggtcgg gtcgatcgcg atcgtgcacg agacgctgtc
    19801 gcacaccccg gacgagctga tcgacttcga cgacatcgcg gaccgggtga tcatgatggc
    19861 gggggaggtg tcgacgccgg agaccaaggt cgcgccgaag cggaccggca gcttcggcgt
    19921 gctgcccgcc gagatcgcga cgccgctggc gatggcgctc accgagctgc tgcagaacgc
    19981 gctggagcac ggcctcacga accggttcgg caccctggag gtcgtcgcgc accgctacgg
    20041 cgagggcacc ccgccccgcg agccggaagg ggtgccggtc tggggggagt ggcctggctc
    20101 cgacgcgcac gacccgcgcg cccacaagga gccgtccgcc gcgcgcccgg ccgcgaccgg
    20161 cccgcggctc gtcgcggtcg tcgccgacga cggcgtcggc ctgcccgccg acttcgacgt
    20221 ggagagcagc aacagcctcg ggctgcagat cgtccgcacg ctgatcgtcg gcgagctcgg
    20281 cggcagcctc gacttccgcg accggccggg cggcggcacc gaggtcatcg tggacgtccc
    20341 gctcgaccac accaacaggc cccccgggca ccgctaggcc cggcctcttt cggaacggcc
    20401 ccgccggggc ctgccatcac gagcccgaag acgccgagtg cccgcatgcc cgtttccggg
    20461 cagcgggcac tgcgaagtgc ggtgcgggcg gcgccggggc ttccggccct gggggttcgg
    20521 aggcggcgcc gcgcgtcggt cgagcggtcg tgcgagcggg gttacagacc ggcgttggcg
    20581 cgggcccggg cgcggctggc gcggcgcttg agggcgcggc gctcgtcctc gcccatcccg
    20641 ccccagacgc ccgagtcctg gccggactcc agcgcccagc gcaggcacgc gtcggtgacg
    20701 tcgcaacggc ggcagacctg cttggcctct tcgatctgca ggatcgccgg cccggtgttg
    20761 ccgatcggga agaacagctc ggggtccacg tcacggcagg cagcgcggtg gcgccagtcc
    20821 atgcggtcca ctccttcgtc aggtggtgtg agacactcca cgtttgtgaa cggtttcaca
    20881 tgtcgcgaac gcccggagcg gcggtggccg gcgatccagg ggtgattgtt ccgcggcgct
    20941 gcgatcagga ggcggacgac gttggggccc ctgtcggctg gcgcactttg agcgtgtcag
    21001 ccgggcgcgg gcaggcgcaa gacctttgag aaaggattct caaagtatgg gtgtcgcatg
    21061 tgtcacacca gtgggtcggc cgtgttactt ggctctcagc agggcgtgac ggcggtctca
    21121 gatgaggatg cggaccgcct tcggcaccga ccggaacgtc acgctgcgct gttctccgag
    21181 gtagtcgccg tccagctgaa aggcgatcgg acggtccgcg cgcaaggtga cctccgtcgc
    21241 gtcgtgcacg ttcagcacat ggcggccctg caccggacgc gtccgcacca gcatcatctg
    21301 cgcgagcgcg ccgaggatcg gcccggcggc catcgtccgc atcccgaaca cgtccagccc
    21361 gcgcgagaag ttcgacttcg gactcggatt caccggcagc cggcccgcga aagtccacgg
    21421 cgcggtattg gagacgaacg ccaggaacag gcccgctttc ggcgggcgcc ccggcacttc
    21481 cagcgtgagc gccggatggc gccgatccgt gcccgtgaag aaatggcgga ccgcggcccg
    21541 cacgtacagc gacggatcgg ccttcgcgcc cgctccgcgc cgccgctcca cctcccggac
    21601 gacctccgcg tccagcccca ctcccgcgtt gaaggtgaaa tagcgctgca cgccgtccgg
    21661 caggcacgcc gccccgagcc cgaccgtccg gtaccgcccg gcgcgcagcg cctccagcac
    21721 cgccttcgtc gcgccgaccg ggtcgttcgg cagcccgagc gcgcgggcga acacgttcgc
    21781 gctcccggac ggcagcaccg cgagggccgg caggtccgcc gacgggccgt ccgcgagcag
    21841 gccgttgacc gtctcgttca ccgtgccgtc gccgccgagc gcgatcaccg cgtcgtagcc
    21901 ctcgacggcg gcccgccggg ccagctcggt cgcgtgcccg cggtgggccg tctcggcgat
    21961 ctcgaggtcg agatcgccgg tgaaggcccg caccaggatg tcgcgggccc gccgggaggt
    22021 ggaggtcgcc ttggggttgg cgatgagcat ggcgcgcacg gcgccagcgt atcgagcgtt
    22081 tcccgtgcgt ttccccacgc atcggccgct gcggcgggcg agtagggttt cgttgtgacc
    22141 gaccgtccca tcaccgtgcg ggccgccgcc gccctggagg gcgcggaggg cctcggcgcc
    22201 gtcgcgttcg gcgtctacac cggcgtcgag accgccgccg gcgccgccgt cgacccggtg
    22261 agcgcgatcg gggtgaccgt cctctcgctc gccggcggcc tcggcatgct cgcctgcgcc
    22321 cgcggcctgc tccgcggcgc ccagggcagc cgcgccccca cggtcctgac ccagctgttc
    22381 gcgctgcccg tcgcctggtc gctgtggcag agcgagcggc ccgcgatcgc cgtgccgatg
    22441 gggatcgtcg ccgtgctcgc gctggtcgcc gtgctgagcc cggcgagcac cgcctggctc
    22501 gtccatgatc acgacgagga ggacgaggac gctccgga
//
