LOCUS       NZ_CP053892            31161 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8069397
            Orig. end                         :: 8100558
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..31161
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NI-siderophore"
                     /region_number="22"
                     /rules="IucA_IucC"
                     /tool="antismash"
     cand_cluster    1..31161
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..31161
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[14000:17161](-)"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(14001..17161)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     misc_feature    2621..2636
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.58"
                     /tool="antismash"
     misc_feature    complement(2966..2979)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.57"
                     /tool="antismash"
     misc_feature    2967..2980
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.16"
                     /tool="antismash"
     gene            2991..4151
                     /locus_tag="ACTIVE_RS36255"
                     /old_locus_tag="ACTIVE_7277"
     CDS             2991..4151
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1192: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017589238.1"
                     /locus_tag="ACTIVE_RS36255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7277"
                     /product="RNA-guided endonuclease TnpB family protein"
                     /protein_id="WP_216858088.1"
                     /transl_table=11
                     /translation="MKIVVQVRLIPDAAQAVALECTLHTVNECANQVSAASFAAYGLNG
                     SVKNLRSMAYGQLKARGLGAQAAQHVIKRVVDAYTTLRANLRAGNLGGEGSKRRRKATS
                     KPIAFRADAAHTYDDRCLSWNYDGQTVSIWTMDGRLKNVRFACSAGALKQLTQYREGES
                     DLACRDGKWFLIATCEIPEAERYEPQDWLGVDRGIANLATTSDGDNHSGRRLDRYRRWK
                     ARKKAELQAKRTCSAKQLLKKRARRESRHATHINHKVSKTVVAVAQRTERGIALERLQG
                     IRERVTVRRDQRARQSSWPFHQLGAFIAYKARRAGVPFIEVDAAYTSQRCPRCGHTAKA
                     NRPSRDAFSCRRCGLAGPADVVAGVNVRDRARSAWVFVNMPQPAPA"
     misc_feature    complement(4173..4188)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.88"
                     /tool="antismash"
     misc_feature    complement(4261..4275)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.14"
                     /tool="antismash"
     gene            4342..5121
                     /locus_tag="ACTIVE_RS36260"
                     /old_locus_tag="ACTIVE_7278"
     CDS             4342..5121
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634679.1"
                     /locus_tag="ACTIVE_RS36260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7278"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_173099204.1"
                     /transl_table=11
                     /translation="MTVTHGDKVVREFSKQAAGFADPRLNVAFTRHLDDLVRFMDPELD
                     LEDNVLEVAAGTALVSRAIARRVRHVTALDLTPAMLAEGKREADRQGVTNVTFTRGDAT
                     ALPYLDRTFTLVVTRFSLHQVADPEAVVREMARVSRPGAALIIADLVRPDGLAGDPDRI
                     ERLRDPSHGTMLTRERIADLATAAGAEVKRTQWIDFTRPLEPWLELARTPADDAAQIRR
                     ELEDELSGGPATGMRPSREDGALHFTHSYLFQHAIVG"
     misc_feature    5146..5161
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.47"
                     /tool="antismash"
     misc_feature    complement(5147..5160)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.77"
                     /tool="antismash"
     gene            5195..5503
                     /locus_tag="ACTIVE_RS36265"
                     /old_locus_tag="ACTIVE_7279"
     CDS             5195..5503
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658155.1"
                     /locus_tag="ACTIVE_RS36265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7279"
                     /product="hypothetical protein"
                     /protein_id="WP_173099205.1"
                     /transl_table=11
                     /translation="MGSSTVRPLDREPAALAMRIGVVAAEAALATFARNLDLDDLEDGI
                     DFQGAIGPAEWPVFSLVIDTLAEAGPGDRRSLDERRADALNDLARICMAAKTRAGAA"
     gene            complement(5582..7177)
                     /locus_tag="ACTIVE_RS36270"
                     /old_locus_tag="ACTIVE_7280"
     CDS             complement(5582..7177)
                     /NRPS_PKS="Domain: AMP-binding (54-441). E-value: 2e-71.
                     Score: 232.7. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS36270_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658154.1"
                     /locus_tag="ACTIVE_RS36270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7280"
                     /product="AMP-binding protein"
                     /protein_id="WP_246342397.1"
                     /sec_met_domain="AMP-binding (E-value: 8.7e-74, bitscore:
                     247.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQRVRSVASLGVRATRAVRDTGIMHPVRPDRAARLLFPYVRFGP
                     VPATVGAMAALRFPGRTALIDERGALTYAELEERAASLATALRDRVGDGKVGVLCRNHR
                     GFVEAVLAASRLGNDVVLLNTDFSATQLGQVAEREGVELLVHDEEFGPAVDDSGFAGER
                     VLGWTDGAGDGDSIDALVAATDAEPLNPDRSSNVIVMTSGTTGTPKGARHDLSVTSLLP
                     AALSHLMRVPVRSGAPVVVAPPLFHILGFAYTSVGLGMGMPLVLFRRFDPDEVLKAIAD
                     REAETLVAVPVMLQRILDAARRERRRTPSLRVVVCGGSALHPHLSEAFMDEFGDVLINV
                     YGATETGWATIATPEDLRAAPGTVGRPSFRLTVRILDEDGNEVPDGGTGEIYTGGGLRF
                     AGYTGGGGKKVRDGLTGTGDLGHFDAEGRLFIDGRADDMIVSGGENVFPGEVENLLGEH
                     PEVAEVTVKGVDDEKFGQRLAAYVVRKENSQVTEDDLKAHVKKHLARYKVPRDVHFVDE
                     LPRTSTDKVRSKQL"
     aSDomain        complement(5855..7015)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS36270_AMP-binding.1"
                     /evalue="2.00E-71"
                     /label="ACTIVE_RS36270_AMP-binding.1"
                     /locus_tag="ACTIVE_RS36270"
                     /protein_end="441"
                     /protein_start="54"
                     /score="232.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ALRFPGRTALIDERGALTYAELEERAASLATALRDRVGDGKVGVL
                     CRNHRGFVEAVLAASRLGNDVVLLNTDFSATQLGQVAEREGVELLVHDEEFGPAVDDSG
                     FAGERVLGWTDGAGDGDSIDALVAATDAEPLNPDRSSNVIVMTSGTTGTPKGARHDLSV
                     TSLLPAALSHLMRVPVRSGAPVVVAPPLFHILGFAYTSVGLGMGMPLVLFRRFDPDEVL
                     KAIADREAETLVAVPVMLQRILDAARRERRRTPSLRVVVCGGSALHPHLSEAFMDEFGD
                     VLINVYGATETGWATIATPEDLRAAPGTVGRPSFRLTVRILDEDGNEVPDGGTGEIYTG
                     GGLRFAGYTGGGGKKVRDGLTGTGDLGHFDAEGRLFIDGRADDMIVS"
     CDS_motif       complement(6545..6586)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS36270_0001"
                     /evalue="1.80E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="ACTIVE_RS36270"
                     /protein_end="211"
                     /protein_start="197"
                     /score="14.5"
                     /tool="antismash"
                     /translation="IVMTSGTTGTPKGA"
     gene            7293..8303
                     /locus_tag="ACTIVE_RS36275"
                     /old_locus_tag="ACTIVE_7281"
     CDS             7293..8303
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024273.4"
                     /locus_tag="ACTIVE_RS36275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7281"
                     /product="VOC family protein"
                     /protein_id="WP_173099206.1"
                     /transl_table=11
                     /translation="MLSVFLACEDPYATADFFTGSLGWRLVFATPRASADRLACVSLGD
                     AQVMLSTDDEEFLPAASREHRGAGVTVYVRLPDTADIAAVHARHAEAGVVTAPLSAREW
                     GERAFDARIGGYRFLVAQEGTVDGMPSTVTADDLESAVRLAVTTLEKAPDGAWDGKAGG
                     LEWTCWETVEHLSDDLFAYAAQLGARPANREVPFLWESRRPGGPANVTYANRDAGPGGL
                     LEVLEACGAMLAALVRTTPPDVRAHHVFGASDPEGFAAMGIVETLVHTHDITQGLGLAW
                     DPPADVVARTLARLFPDAPRDTAPWPTLLWATGRGDLPGRERLTQWRWNGTPRLS"
     gene            complement(8296..10575)
                     /locus_tag="ACTIVE_RS36280"
                     /old_locus_tag="ACTIVE_7282"
     CDS             complement(8296..10575)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS36280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7282"
                     /product="hypothetical protein"
                     /protein_id="WP_173099207.1"
                     /transl_table=11
                     /translation="MTAPDKVSGGIDQIVFTWSDRLLTGGSGLGPVASSLDPNELARWS
                     ALLEGGAIATGQWLQGAAKCVALGALRVGRKGDLGAVLRLMPDRDPYGHSTQAMHALVG
                     KASVVNAELALGLHNWPGWITPDMVDNMVTTLQVRSAVGLREYAARQLDALTAPREPLA
                     ALLAGVLAAPDRAYLAALAPDDYGLVAGLVRRMAGLAGPEPWTIMLGATVTREEARPRL
                     LVLDLPDAGRGRTPLAPDAVAVQNLARAGRLLAGMPPASLNPPPTPLTDTAKLLAWVEA
                     EHQRTAGVLDLIDAALGGTLDEQDRRRLESAAGAEELRAELRSVDPADLAVRLERWPAA
                     PPPGLAGIGRTLRRVAVQRALTDVRAALQAAERLINAACDMGVTPEEASGVLADWRARS
                     PDITPTQRLAGVYVALRLEINPASDGTADDLLSGLAPRALLEWSTRLTTPLPPEVALRA
                     IRAAYARWRRSHGRTGDPQVRELLRTTGLLHETVREITQHRYDRTEVESELYRILLLMA
                     FGDEVGDVGDVGAILSMLPPDAPATAFRPWLGLAGALRGRDAVFQVAAHARERNAPVAL
                     LAEMLHRLPSHDLVLGLAEHRDRAALLLPVCSLLEAREPGRSELHDTREALFGAFFLIE
                     AAESALYAAPDRLRAYSILLRAAYPAGDRSEGGGLTAEEVAELLDLDGPPLFVAAVLDA
                     AAEDAVLPIVLDQMRRRLGEAGLEPAVVERVLRRPYRWINGRPHEERPPRPEPPVEHDP
                     EVWSLS"
     misc_feature    complement(10363..10365)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10645..11949)
                     /locus_tag="ACTIVE_RS36285"
                     /old_locus_tag="ACTIVE_7283"
     CDS             complement(10645..11949)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012862.4"
                     /locus_tag="ACTIVE_RS36285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7283"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_173099208.1"
                     /transl_table=11
                     /translation="MRLPHPHKSRVVLLGSSSYADESLPDVPAVRANLADLAAVFTDPD
                     HGIVAPENCVRILDESDLARLGSTLRTAFREAEDTLLVYFCGHGVTGGRRHDLYLALPG
                     SDAGYPEFNALEYDKLRSALLDSPAKTKIVILDCCLSARAFDHSLSDGTSVVDMLDVEG
                     GYVLASAGRDKVALAPEGERHTAFTGQLLRLLTDGVPEGPDLLTLDLLYRQLRTIMRGA
                     GLPEPERIGTNTADRLGLGRNRALTSGPALLERQAAAIALAESGDWPGATGLLRVILKD
                     QERVLGAAHEATLRTRQYLAHGQGQVGDPRGAAEDLERLLPEQSGVLPADHDDVLRTRQ
                     YLAVNLGEAGDRDRAVALLRVLLPDRRRVLGHQHPDTLRTSHMLARNLALTGCREEAAA
                     LLRELLDVREHLIGADHPHTVRTRRDLAALTDEPA"
     gene            complement(11952..12302)
                     /locus_tag="ACTIVE_RS36290"
                     /old_locus_tag="ACTIVE_7284"
     CDS             complement(11952..12302)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040404.3"
                     /locus_tag="ACTIVE_RS36290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7284"
                     /product="hypothetical protein"
                     /protein_id="WP_173099209.1"
                     /transl_table=11
                     /translation="MSATISLQGQSADLENLHDWLAGERELQGRVRPAAPEPSPGELGD
                     VSDILLVTLGSGGAVSVLAASLRGWLAQPRRASVKIQLKTEQGETLTIDAKNVKDRSVE
                     TILNRALDGGRD"
     gene            complement(12434..12919)
                     /locus_tag="ACTIVE_RS36295"
                     /old_locus_tag="ACTIVE_7285"
     CDS             complement(12434..12919)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS36295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7285"
                     /product="hypothetical protein"
                     /protein_id="WP_173099210.1"
                     /transl_table=11
                     /translation="MADIYDFFLAINLRDLPDAETAELRWHLGLGPQPAELTIPIDFSE
                     VIVDDDGEPTTVQTPEPQLAQRGPAWKIGGALFAALEPRENGGWALTARQELHPDYYDH
                     VEPLLEWLAARADYPYVDVDGTTKSGGAGNYVGHERWYEDSAIDRVLVIENFKLLRR"
     gene            complement(12931..14004)
                     /locus_tag="ACTIVE_RS36300"
                     /old_locus_tag="ACTIVE_7286"
     CDS             complement(12931..14004)
                     /EC_number="5.1.1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_DAP_Arg_deC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012855166.1"
                     /locus_tag="ACTIVE_RS36300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7286"
                     /product="alanine racemase"
                     /protein_id="WP_173099211.1"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.7e-16,
                     bitscore: 58.2, seeds: 500, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 8.3e-23, bitscore:
                     80.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLDDVRDLDRFPAYVYDLPGLETHVESIRAALGRTELFYAAKAN
                     PDAEILRAVAPHVDGIEVSSGGELAHVRETLPDIRLAFGGPGKSDEELALATGVDRLHV
                     ESPRELDRLRGPADVLLRANLPLHAPGAALTMSGPFGMDEDALEECARRITGNPHITLR
                     GVHAHLASGLDAPAMLDLAHRIAEWAIPWLKTHGVDDPELNIGGGMAVDYTSPESRFDW
                     RAYGAGLADIPTRLRIEPGRSMTAYHGWYVTDVLDVKTTRGETYVILRGGTHHLRTPVT
                     KGHDQPFKALTANGPESPATLVGQLCTPKDVFARDVPVPSLRPGDVIAFAMAGAYAWNI
                     SHHDFLMHPEPAFHYIR"
     gene            complement(14001..15593)
                     /locus_tag="ACTIVE_RS36305"
                     /old_locus_tag="ACTIVE_7287"
     CDS             complement(14001..15593)
                     /GO_process="GO:0019290 - siderophore biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658153.1"
                     /locus_tag="ACTIVE_RS36305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7287"
                     /product="IucA/IucC family protein"
                     /protein_id="WP_216858089.1"
                     /sec_met_domain="IucA_IucC (E-value: 1.6e-52, bitscore:
                     177.6, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLTERALTADDATSTALLNCLIREVCGPEQQVRPDGAHLVARLP
                     RAGVVLRTGLARPPAGPTYRLAPPYEERRGDAWIPASWDRLADLVAGELELATGQPNPE
                     FLAQVGDSHSALAAIIAARHAPQDDRYLESEQSLVAGHRFHPSPKSRQGSPAEWLRYAP
                     ETRARFRPRWLAVRDDAVAEEGDPQAFAALGGPSVPGCRTLPVHPWQFSLLAGNPLLQD
                     ALARGLVRDLGPSDVEAVPTSSVRTVYLPDADLFCKFSLDVRITNCVRKNAWYELSGAV
                     ALNDLLRPVFTSLGATLLAEPAYRSVALADRRLYEGLGVIVRQGVKHLPGTPLLAGALA
                     DPYNTLLNDLPALSTADGALAWWNAYVAQVAPPVLRAFLEHGVVLEPHLQNVLICVDED
                     GMPVHAAFRDLEGTKLTAGRWDLSHLPARVAESLTYTPAHGWNRVVYCLLVNHLTETAA
                     AVADLHPALEADLWKAARAHLAHLDHHPQIRALLAGVPLPAKANLRTRWSRSADRGAAY
                     VPAPNPLSAPLPL"
     gene            complement(15584..17161)
                     /locus_tag="ACTIVE_RS46950"
                     /old_locus_tag="ACTIVE_7288"
     CDS             complement(15584..17161)
                     /GO_process="GO:0019290 - siderophore biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013133201.1"
                     /locus_tag="ACTIVE_RS46950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7288"
                     /product="IucA/IucC family protein"
                     /protein_id="WP_216858090.1"
                     /sec_met_domain="IucA_IucC (E-value: 3.2e-25, bitscore:
                     88.1, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPDIEGRLAARVLDALIREDYAGVRRFVENRTLALPGRPVKLV
                     DADPAFLSELRVDPSQNLALRDVFALVRHLADPRDDTEAFERECLDALATVKLHNDARP
                     AVHRRLARIPDALRTGPGTFYESLAAYNDHPVHPTSRSRAGLSMADLSRYAPEFAPSFP
                     LRWASVRGATLVGEPPVWWPSPADVGLRSADALFPVHPLAVRLVRDQPAATMAPEPYLQ
                     VSPTLSMRTVAAAPLEHVKVPLPTSTLGLRNRRTIVPGTLPDGALVERVLRRVLDREPH
                     LPVLLADEQTYGHADNPLLAYLVRRFPAETARAHIVPIAALVAKAPDKGHVIERWDVEP
                     LFDTYLAALFAWNVTLFRYGIALEAHQQNVALVLDGHGPPRLLVKDNDGALINPARLRA
                     RLGPSPGADPRDLVDRRMVTADPDALARVFVTITLHLCAAAPALGLAERGLLPWRTGRA
                     LIRDRLDAALGPPDAFLRSRTLDADALPGKAMVTAGTLVDKARTGAADINKHYGPPGPN
                     YLRDATCF"
     misc_feature    complement(16430..16432)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(16832..16834)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17158..18300)
                     /locus_tag="ACTIVE_RS36310"
                     /old_locus_tag="ACTIVE_7289"
     CDS             complement(17158..18300)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634673.1"
                     /locus_tag="ACTIVE_RS36310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7289"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_246342398.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 7.3e-06, bitscore:
                     25.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAASLYLVAGKATDSVTHGFLPAAARLGLDVVLLTDRPAAHAHAA
                     GRVVECDVSDFRHIIDRVEGEPAGIFSNSDFLQVPAALAAAYFGLPGKDWRAAARAKNK
                     GLMRRHLAALDPVFSADAFHVPPDAPYPLVVKPREGVASEDVFLVHDARELETRREDIA
                     ARRSDPLVAEEYLPGRLHTLETLGDGRELRVLGSYRTTVSPPPFFVEERLEWAPPPPET
                     PQILAQLDALGVGFGACHTEFVVHEGRARIIEVNYRLIGDHCDFLMADLLGIPLFERIL
                     GVHLGEPPALEVPAVRGHAVAEAVIADRAGVLCAAPGPMELDDGAVRLAYLPQRAVGDP
                     VALTRTNRDYLGTVRAIGPGRDEVEAAVARFRSAHEWTIA"
     misc_feature    complement(18324..18342)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 27.98"
                     /tool="antismash"
     gene            18440..19048
                     /locus_tag="ACTIVE_RS36315"
                     /old_locus_tag="ACTIVE_7290"
     CDS             18440..19048
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658150.1"
                     /locus_tag="ACTIVE_RS36315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7290"
                     /product="HD domain-containing protein"
                     /protein_id="WP_173099214.1"
                     /transl_table=11
                     /translation="MDLVERWVALAGPQTRHIGTELDKRYGEPHRKYHTREHLTAVLDL
                     VDELAADAADPEAVRLAAWFHDAVYDPERADNEERSARLAARMLADTDLPAATIDEVVR
                     LVELTVTHAPGPGDRNGQVLCDADLAVLGADPGRYGAYAAAVREEYAFVPEDLFRAGRA
                     DVLNGLLALPHLFHTATARERYEDRARRNIETELMLLNA"
     gene            complement(19059..19337)
                     /locus_tag="ACTIVE_RS36320"
                     /old_locus_tag="ACTIVE_7291"
     CDS             complement(19059..19337)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013151835.1"
                     /locus_tag="ACTIVE_RS36320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7291"
                     /product="DUF4031 domain-containing protein"
                     /protein_id="WP_246342399.1"
                     /transl_table=11
                     /translation="MVLIDPPLWPARGRVWSHMVSDVSYEELHAFAAELGMPVRAFDRD
                     HYDVPSELYEAAVAQGAEAVGCQELLLRLTRAGLRRRKAVRRRSTAV"
     gene            complement(19448..20650)
                     /locus_tag="ACTIVE_RS36325"
                     /old_locus_tag="ACTIVE_7292"
     CDS             complement(19448..20650)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1192: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020380061.1"
                     /locus_tag="ACTIVE_RS36325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7292"
                     /product="RNA-guided endonuclease TnpB family protein"
                     /protein_id="WP_173101656.1"
                     /transl_table=11
                     /translation="MRTAYKCRAYPDPEQAAVFNRTFGCVRLVWNKTLAERHRAWHADG
                     NRGSYKETDAALTAWKKTEDLAFLNEVSSVPLQQALRHQHAAFANFFAGRARYPRFKNR
                     NSRQSAHYTRSAFRMRDGELRMAKTTAPLAFVWSFDDVDLVTLNPTMVVISRDCDGRWY
                     VTFAVDTDERVPLPAAEHQIGVDLGVKDFAVTSDGDRIANPRHLEKKQRNLARYQRRMA
                     RCRPGSNNRRKAKAKVARAHRKVRDARADFLHRTSTGLVRRADTIVIEDLNVSGMVRNR
                     TLARAISDCGWGEFRRQLEYKCERAGRTLVVIDRWYPSSKTCSACGHLLAELSLSTRRW
                     TCPGCRTRHDRDHNAAKNILAAGRAVAGDTPGDVCGADVRRQGTSLPQSAAKQKLPRRE
                     P"
     misc_feature    20650..20664
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.54"
                     /tool="antismash"
     misc_feature    20651..20664
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.13"
                     /tool="antismash"
     misc_feature    complement(20656..20669)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.37"
                     /tool="antismash"
     misc_feature    20658..20671
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.08"
                     /tool="antismash"
     misc_feature    complement(20692..20711)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 25.01"
                     /tool="antismash"
     gene            20802..22199
                     /locus_tag="ACTIVE_RS36330"
                     /old_locus_tag="ACTIVE_7293"
     CDS             20802..22199
                     /EC_number="3.4.13.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634669.1"
                     /locus_tag="ACTIVE_RS36330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7293"
                     /product="dipeptidase"
                     /protein_id="WP_173099216.1"
                     /transl_table=11
                     /translation="MNDPVQEIVDYIEAGRDRFIADLKEWLAIPSVSGDPAYATEVRRS
                     AEWLTGYLRGQGFPTVETWETPGLPAVFAEWPAADPSAPTVLIYGHHDVQPVEPLDEWD
                     TAPFEPVEKDGRLIGRGSSDDKGQVFFHTLGIRAGLAASGADAPPVTIKLLVEGEEESG
                     SVHFAGLLRERRDRLRCDAIVISDTTMWAADVPSMCTGMRGLTEAEVTLRGPSSDLHSG
                     SFGGAVPNPLHAMATLMAALHDADGRVTLPGFYDDVVPLTDEERALFAKLPFDEAEWLR
                     TAGGSRAADGEKGYTTLERVWARPTAEINGMWGGHTGPGGKTIVPREAHAKISFRLVAG
                     QDPAKVQQAFRDWVAANTPHGVEAEVHIPGGGVRPCFSPIDSPGVTAARRAMERAFGRE
                     VLFTREGGSGPEADLADILDAPLIFVAVGLDDDRIHAPNEKVEIPLLLKGAEAAAYLWE
                     ELATALR"
     gene            22235..23152
                     /gene="nudC"
                     /locus_tag="ACTIVE_RS36335"
                     /old_locus_tag="ACTIVE_7294"
     CDS             22235..23152
                     /EC_number="3.6.1.22"
                     /GO_function="GO:0000210 - NAD+ diphosphatase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="nudC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658147.1"
                     /locus_tag="ACTIVE_RS36335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7294"
                     /product="NAD(+) diphosphatase"
                     /protein_id="WP_173099217.1"
                     /transl_table=11
                     /translation="MTVTEGPLEWLALARGTLDRVALKRRDDAWLAAAWADPATRVLVV
                     QDGRTLVTYTPEPALAFVAPAQAPDGDRWLLGVDDAGTAYFGVPGELPALDGAEPAGLR
                     RVGALLADRDAGLLTHAVALEHWHGTNRFCPRCGAETRVTSAGHVRVCSQDGSQHFPRV
                     DPAVIMLVTDADDRILLARGPQWPADRRSILAGFVEPGESLEQTVAREVEEEVGLAVRD
                     VRYLGSQPWPLPQSLMLGFTATADGTLPLRPDPEEILDAGWYTRDELRAAIEAEEIVAP
                     GPLSIAAQLIMRWYGGELPRMPAF"
     gene            complement(23233..23514)
                     /locus_tag="ACTIVE_RS36340"
                     /old_locus_tag="ACTIVE_7295"
     CDS             complement(23233..23514)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017574120.1"
                     /locus_tag="ACTIVE_RS36340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7295"
                     /product="mycoredoxin"
                     /protein_id="WP_173099218.1"
                     /transl_table=11
                     /translation="MATPTTDRAEGPTGQLTMYTTTWCGFCRRLKSQLARDGIEMVEID
                     IERDPKAAEFVMSVNGGNQTVPTIVYPDGSAATNPSAKAVKAKLASLT"
     gene            23688..25754
                     /locus_tag="ACTIVE_RS36345"
                     /old_locus_tag="ACTIVE_7296"
     CDS             23688..25754
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658145.1"
                     /locus_tag="ACTIVE_RS36345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7296"
                     /product="ATP-dependent DNA helicase UvrD2"
                     /protein_id="WP_173099219.1"
                     /transl_table=11
                     /translation="MLAESVLEGLDPEQREVAEAVQGPVCVLAGAGTGKTRAITHRIAY
                     ATLTGVVTPQRVLAVTFTTRAAGELRSRLRQLGAPGVQARTFHAAALRQLSYFWPRVIG
                     GDPPKIIDSKIGLVADAARACGLSLGRTEMRDVAGEIEWAKVTQNRPEDYPAAVVRAGR
                     RPSTEAVDVARVYAMYEQLRRERNLLDFEGMLELTAAVLTEHREVANQVREQYRYFVVD
                     EFQDVNPLQKMLLDTWLGGRHDLCVVGDPNQTIYSFTGASPSYLLGFTREHPDAKVVKL
                     VRDYRSTPQVVRLANGVIDQAKGTRHRLELVAQRENGPEPVFNEYDDEVAEADDTARRA
                     RKLIDEGVPAREIAVLFRINAQSQTYEAALAAVGVPYVLRGAERFFERPEVREAVVRLR
                     GAARAGADAETDGTGLIMTVRHVLSGAGFSDRPPEGAGAARARWESLAALAQLAEDMAA
                     DDPKAGLPEFVAEIEERAAAQHAPPLEGVTLASLHAAKGLEWDAVFLVGLAEGTLPIVY
                     AKTPEQIEEERRLLYVGVTRARVHLTLSWALARSPGGSQMRRPSRFLDGLTGKTTTHTP
                     ARVDRTKRRVTKGPQPCRVCGRPLTAAVERKLGRCEDCPSELNEELFVALKDWRAEVSA
                     EQRIPAYVVFTDATLQAIAENRPDSMEDLARIPGVGKVKLDRYGEAVLGLCGT"
     misc_feature    complement(25798..25813)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     gene            25840..26715
                     /gene="tesB"
                     /locus_tag="ACTIVE_RS36350"
                     /old_locus_tag="ACTIVE_7297"
     CDS             25840..26715
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006637 - acyl-CoA metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="tesB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854059.1"
                     /locus_tag="ACTIVE_RS36350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7297"
                     /product="acyl-CoA thioesterase II"
                     /protein_id="WP_173099220.1"
                     /transl_table=11
                     /translation="MSDSLKALLDLLDLEQIENDIFRGRSPEERRQRVFGGQVAGQALV
                     AAGRTVPVNRPVHSLHAYFIRPGDPLVPIVYTVDRVRDGRSFTTRRVSAVQHGKVIFTL
                     SASFQVVEDGPAHHAPMPDAPDPETLPDSLTRLTPLFGEAGARAFVERRPFDVRHATPL
                     TWEAAKDPALASPESVVWLKVLGDLPDDPLLHVCLMTYASDMTLLDTVLLNHGLAWGDK
                     RTMGASLDHAMWFHRPFRADDWLLYYQDTPFAGGARGLARGQVFNRAGELVVSVMQEGL
                     VRVSDSGRER"
     misc_feature    complement(26835..26850)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.15"
                     /tool="antismash"
     gene            26964..27314
                     /locus_tag="ACTIVE_RS36355"
                     /old_locus_tag="ACTIVE_7298"
     CDS             26964..27314
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS36355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7298"
                     /product="hypothetical protein"
                     /protein_id="WP_173099221.1"
                     /transl_table=11
                     /translation="MINTSMKSLSSWTAACPGTSTAYAVSCVRTPLGVKPGGPARHGVA
                     LSANAAGERLRVDGTRLRDLRDLRLEQRIQDEQGWSVFAFEGMTSQAPATAHMGATPAG
                     GVSGPYPWRRPV"
     misc_feature    26981..26992
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.68"
                     /tool="antismash"
     gene            27436..27714
                     /locus_tag="ACTIVE_RS36360"
                     /old_locus_tag="ACTIVE_7299"
     CDS             27436..27714
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017542399.1"
                     /locus_tag="ACTIVE_RS36360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7299"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_173099222.1"
                     /transl_table=11
                     /translation="MQGALAISEEDLTLPCRTDPELFFAEAPADVELAKALCLECPLRK
                     ECLAGALERKEPWGVWGGELFVRGVIVARKRPRGRPRKHPLPDEAAV"
     gene            27812..27976
                     /locus_tag="ACTIVE_RS36365"
                     /old_locus_tag="ACTIVE_7300"
     CDS             27812..27976
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS36365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7300"
                     /product="hypothetical protein"
                     /protein_id="WP_173099223.1"
                     /transl_table=11
                     /translation="MTLLSQDLSRERIPATAPDALAVRVRALRRARREAQTRASRVRRV
                     LLAPTSSRD"
     gene            complement(28270..29601)
                     /locus_tag="ACTIVE_RS36370"
                     /old_locus_tag="ACTIVE_7301"
     CDS             complement(28270..29601)
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634662.1"
                     /locus_tag="ACTIVE_RS36370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7301"
                     /product="AarF/ABC1/UbiB kinase family protein"
                     /protein_id="WP_246342400.1"
                     /transl_table=11
                     /translation="MSDLPRRAVTRSAKLASLPLGFAGRTALGIGKRTIGRPAEAVAME
                     IQTRTAEQLFKVLGELKGGAMKLGQMLSIFEAALPPEIAGPYRATLTRLQEAAPPLPAS
                     AVHKVLAEALGEDWRDSFESFDDKPAAAASIGQVHRAVWSDGRAVAVKVQYPGAGKALI
                     SDFNQLARLGRLFGILMPGLDVKSMLSELKERVVEELDYTIEAESQTIIRDAYADDPDF
                     YIPEVIAQSGDVLVTEWMEGTPLSKIISDGDQDTRNHAALLYCRFLLSGPKRSGMLHGD
                     PHPGNFRLLDDGRLGVLDFGAVDRIPGGFQKRLGLLLRIGTMADIDEIEDALRDEDFIR
                     EGVEVDAEALQAFLAPITEPFVTETFKFNREWLRDMAARVTDLRPTNVVRQLNLPPEYV
                     IIHRVLSAGTGVLCQLECEIPARAESLKWVPGFADDEDGELVTG"
     misc_feature    29707..29722
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.8"
                     /tool="antismash"
     gene            29812..30612
                     /locus_tag="ACTIVE_RS36375"
                     /old_locus_tag="ACTIVE_7302"
     CDS             29812..30612
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (13-257). E-value: 1.9e-56. Score:
                     183.1. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS36375_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658137.1"
                     /locus_tag="ACTIVE_RS36375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7302"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_173099225.1"
                     /transl_table=11
                     /translation="MSGEQPEVLRVERRPDGVAVLTLNDPGRRNAMSDEMTAAYKQAIA
                     DLRGDSGLRCVVLTGAGTAFSSGGDLSWLADTNSVAVPALRDRMLEFYRTWLTIRSLEV
                     PTLAAVNGHAVGAGLCLALACDLRYAAEDAKLLAPFTALGLHPGMAATWLFPEVAGLPL
                     AREMLLAGRVLTGAEAERKGLVNQAFPRADVLAETLKIAERIAANAPIATRLTKVALAG
                     GGHADMDAALRWESLAQPVTMASEDMIEGLTAQREKRPARFTGA"
     aSDomain        29851..30582
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS36375_ECH.1"
                     /evalue="1.90E-56"
                     /label="ACTIVE_RS36375_ECH.1"
                     /locus_tag="ACTIVE_RS36375"
                     /protein_end="257"
                     /protein_start="13"
                     /score="183.1"
                     /tool="antismash"
                     /translation="RPDGVAVLTLNDPGRRNAMSDEMTAAYKQAIADLRGDSGLRCVVL
                     TGAGTAFSSGGDLSWLADTNSVAVPALRDRMLEFYRTWLTIRSLEVPTLAAVNGHAVGA
                     GLCLALACDLRYAAEDAKLLAPFTALGLHPGMAATWLFPEVAGLPLAREMLLAGRVLTG
                     AEAERKGLVNQAFPRADVLAETLKIAERIAANAPIATRLTKVALAGGGHADMDAALRWE
                     SLAQPVTMASEDMIEGLTAQRE"
ORIGIN
        1 gacgcctacg acggcccgat ggaccgcatc gagtggcagc ccgacaccgt caccaaggcc
       61 gtcatggagc tgtccggcga cctgtcggag cacctgcgca ccgccgacga cgtccgcaag
      121 gtcggcgcgt ggctggacga gcggttcgcc gcgctgaaga agccgctgaa ggcgcagcgc
      181 gacatcctcg cgaggcaggc cgtccgcgag cagatgatgc cgctgatcga gaagtacggg
      241 caggcgaagg ccggacggga ggtcatcgac cacggcgacc agatggccct ggccgctcgc
      301 atcgcctaca agcatcccga ggtcgggatg atcgagcggt cccggttctc ggtcgtgctg
      361 ctcgacgagt accaggacac cagccaggcg cagctcgtcc tgctgaagtc gctgttcgcg
      421 ggcgggcatc cggtgacggc ggtcggcgac ccgtgccagt cgatctacgg gtggcgcggc
      481 gcgagcgccg ggaacctgct gcggttcgcc tacgacttcc cgtcgcagcc cgcggtcggc
      541 tccgggcgcc cggttccggc gccggtcgtg cagctgagca ggtcgttccg caacggcgag
      601 cagatcctgg aggccgccgc gcggatccag gaggagctgc gggcggagac cgaggccgtg
      661 ccgcggctga tccccggcgc cgggcgcgag gggcgcgggc gtgtcgagtg cgcgctgttc
      721 gagaccgtcg aggacgaggc cgaccggatc gcggggcgca tcgccgggct gatggccggc
      781 gaccccggcg tcgcgccgga cggcggcccg caggccgagc cgctgcggta ctccgacgtc
      841 gccgtcctcg cccggaagcg gtcgcagttc ccgctgatca ggcgggccct ggaggcgcgc
      901 gggatcccgg tcgaggtggt cgggctcggc gggctgctga ccgtccccga ggtgcaggac
      961 gtcgtcgcga ccctgcgcgt catgcacgac ccgacggcgg gcgcgtcgct cgcccggctg
     1021 ctcaccggcc cgcgctggcg gctcggcccg cgcgacctgg tcgcgctcgg ccggcgggcg
     1081 cgcgcgctgg cgcaggagtc ggcgcgtgac gtcaccccgc ccgaacgccc cgcggacgag
     1141 ccgcccgaga gcggcggcga cccggacgcc cccgacgccg cggacgctcc cgagacgccg
     1201 gacgacccgc tgcggcagct cgtcagcgag ctgaaccagg agaccggcag cctcgtcgac
     1261 gcgctcgacg acctcggcgc gcccgaggcg tactcgccgg aggggtacgg gcggctgcgg
     1321 cggctgcgcg acgagctgcg ggggctgcgg agccaggtcg ggctgccgct gcccgacctg
     1381 gtcaacgagg tcgagcgggc gctcggcctc gacatcgagg tcgccgcccg gtccggcctc
     1441 gaccccgtca ccgcgcgcgc cgacctcgac gcgttcatcg acgccgccgc caccttcgcc
     1501 ggcgacgccg aggacccgac gctcggcgcg ttcctcgcct acctcaaggc cgccgagacc
     1561 gaggagttcg ggctggaggc gggccgcgtc ggcgagaccg acagcgtcaa gctgctgacc
     1621 gtccacgcgt ccaagggcct ggaatggccg gtcgtcgtcg tgccgggcct gtcgtacgtg
     1681 ccgcagaaga gcggcggccc cgcgaagggg tcgatcttcc cgtcgccgcc gcagaacgcg
     1741 acccgctgga cggcgaaccc gcgcgtcctg ccgttcatgc tgcgcggcga ccgcgccgac
     1801 ctgccgccgc tgaacggcct ggagaaggac gacctcgccg cgttcgaccg ggcgtgctcc
     1861 gaacgcgacc tgcgcgagga acgccgcctc gcctacgtcg ccgtcacgcg cgcgtcgagc
     1921 ctgctcatca ccaccgggta ctggtgggga tcgtcgggcc ggccgctcgg cccgtcgccg
     1981 ttcctggagg aggtccgggc ggtgtgcctc gccggggccg ggacggtcgc ggtctgggcc
     2041 gacccgcccg aggagggcga gacgaacccg ctgctcgccg accccgaaga ggcgcagtgg
     2101 ccgatcgcgc cgggcgagcg cggcaggacc gacgcgtccg cccgcgaacg ctacgaggcc
     2161 gtcgtcgagg ccgcccgcat ggtcgaggac gccatggccg ggcggaaccg gctgtgggcc
     2221 ggcgacgacg gcctgtccga cgccgaccgc ggccgcatga ccgcgtgggc gcgcgacgtc
     2281 gaactcctcc tcgccgaacg cgaccggggc cgcggcggcg acggcctcct cgtcgagctg
     2341 cccgcgcacc tgtcggtgtc gtcgctggtg tccctcgccc gcgaccccgc cgcgctcgcc
     2401 cggcagatcc gccgcccgat gccgcgcccg cccgccccct acgcgcggcg cggcaccgcg
     2461 ttccacgcct ggctggaggg gcggtggggg cagcagcgcc tcctcgaccc cgacgagctg
     2521 cccggcgccg ccgacgaggg cgccctcgac gactcgcacc tgcgccgcct gcaggagcgg
     2581 ttcgaggagt cggaatgggc gtcccgcgaa cccctcgaca tcgaggtccc gttcgagacc
     2641 atcatcggcg accggctcgt ccgcggtcgg atggacgcgg tgttccggcg gcgcggcggc
     2701 ggctacgagg tcgtcgactg gaagaccggc cggccgccgt ccggcgacga ggcccggttc
     2761 gcgtccgtgc agctcgccgc gtaccggctc gcgtgggcgg agctcgcggg cgtcgacgtc
     2821 ggcgaggtca gcgccgcgtt ccactacgtc gccgcgaacg ccaccgtccg gccggcggat
     2881 ctgctggacg ccgccggcct cgccgccctc ctcgaatccg tccccgccgc ctgaccgccg
     2941 cccgccctcc accagccgtc ttcgcgtaga gtaatgatac ggtcacggat atgaagatcg
     3001 tggtgcaggt cagactcatt ccggacgcgg cgcaggccgt ggcccttgag tgcactctgc
     3061 atacggtcaa cgaatgtgca aaccaggtgt ccgccgcctc attcgccgcc tacggcctca
     3121 acgggtcggt caagaacctg cggtccatgg cctatgggca gctcaaggcc cgtggtctgg
     3181 gcgcgcaggc cgcgcagcac gtcatcaaac gggtggtgga cgcctacacc actctgcggg
     3241 ccaacctgcg ggccgggaac ctcggcggcg agggctccaa gcggcgccgc aaagccacct
     3301 ctaagcccat cgcctttcgg gcggacgccg cgcataccta cgacgaccgg tgcctgtcgt
     3361 ggaactacga cggccagacc gtgtccatct ggaccatgga cgggcgcctg aagaatgtcc
     3421 gcttcgcctg ctcggcgggg gcgctcaagc aactcaccca ataccgtgaa ggcgaatcgg
     3481 acctcgcctg ccgggacggg aagtggtttt tgatcgccac ctgcgagatc cccgaagccg
     3541 aacggtacga gccgcaggac tggctcggtg tggatcgagg catcgccaac ctggccacca
     3601 ccagcgacgg cgacaaccac tctgggcgac gcctggaccg ctaccggcgc tggaaggccc
     3661 gcaagaaggc cgagctccaa gccaagagga catgctcggc caagcaactt ctcaagaaac
     3721 gagcacgccg cgagtcacgg cacgcgactc acatcaacca caaggtctcc aagactgtcg
     3781 ttgctgtcgc ccaacgcacc gaacgcggta tcgccctgga acggcttcag ggcatccgcg
     3841 agcgggtcac ggttcgacgc gaccagcgag cacggcagtc ctcttggccg ttccaccagt
     3901 tgggggcgtt catcgcctac aaggcccgcc gcgccggcgt gccgttcatc gaggtggacg
     3961 cggcctacac ctcgcagcgc tgcccgcgct gcggccacac cgcgaaggcc aaccggcctt
     4021 cgcgggacgc cttctcctgt cgccggtgcg gtctcgctgg gcccgccgac gtcgtcgccg
     4081 gggtcaacgt gcgcgaccgc gcacgctcgg cgtgggtatt cgtcaacatg ccccaaccgg
     4141 ctcccgcctg agcgggagcc ggcgatgtga cctgtgaccg ccctcccata acgggcagcc
     4201 caggagcata agcagagcct tttcggccga gccgataagc ccggtcctgc agaggcgagt
     4261 agttgactga aaggtgtcac tgcccctggt caccgaacgc cgtttcggag atgatccggg
     4321 gaacgcatcc agggaggcga cgtgacggtg acccacggcg acaaggtcgt acgcgagttc
     4381 tccaagcagg cggccggatt cgccgacccg cggctgaacg tcgcgttcac ccggcacctg
     4441 gacgacctcg tccgcttcat ggaccccgag ctcgacctgg aggacaacgt cctggaggtc
     4501 gccgcgggca ccgcgctcgt ctcccgcgcg atcgcccgcc gcgtccggca cgtcaccgcc
     4561 ctcgacctca ccccggcgat gctcgccgag ggcaagcggg aggccgaccg gcagggcgtc
     4621 accaacgtca ccttcacccg cggcgacgcg accgcgctgc cctacctcga ccggacgttc
     4681 accctggtcg tgacccgttt ctcgctgcac caggtcgccg acccggaggc ggtcgtgcgg
     4741 gagatggcgc gggtcagccg gcccggcgcc gcgctgatca tcgccgacct cgtccggccg
     4801 gacggcctgg cgggcgaccc cgaccggatc gagcggctcc gcgacccctc gcacggcacc
     4861 atgctcaccc gcgagcggat cgcggacctc gccaccgccg ccggcgccga ggtgaagcgg
     4921 acgcagtgga tcgacttcac ccgcccgctc gagccgtggc tggagctggc gcggaccccc
     4981 gcggacgacg ccgcgcagat ccgccgcgag ctggaggacg agctgtccgg cggccccgcg
     5041 accggcatgc gcccgagccg cgaggacggc gcgcttcact tcacgcactc ctacctgttc
     5101 cagcacgcga tcgtcggctg aatcgcgcgt ttcgccggaa tgttttcgag cgaatgttcg
     5161 acttgcatcg ctcatgtgtt ctatcttgtc ggccatgggt tccagcaccg tgcgtcccct
     5221 cgaccgcgag cctgccgcgc tggcgatgcg catcggggtg gtggccgccg aggccgcgct
     5281 cgccaccttc gcccgcaacc tcgacctcga cgacctcgag gacggcatcg acttccaggg
     5341 cgccatcggg cccgccgaat ggccggtgtt ctccctggtc atcgacacgc tcgcggaggc
     5401 gggcccgggg gatcgccgca gcctcgacga gcgccgcgcc gacgccctca acgacctcgc
     5461 ccgcatctgc atggccgcca agacccgcgc cggcgccgcg tagcccgccg cgatcgcggc
     5521 gccgggggcc ggccggccgc gtccggggtc ggcggccctg agcccggacg tggccccagc
     5581 cctacagctg cttcgaccgg accttgtcgg tgctggtgcg cggcagctcg tccacgaagt
     5641 gcacgtcccg cggcaccttg taacgggcga ggtgcttctt cacatgggcc ttcaggtcgt
     5701 cctcggtgac ctgcgagttc tccttgcgga cgacgtacgc ggcgagccgc tggccgaact
     5761 tctcgtcgtc gacgcccttc accgtcacct cggcgacctc cgggtgctcg ccgagcaggt
     5821 tctccacctc gccggggaac acgttctccc cgcccgagac gatcatgtcg tcggcgcggc
     5881 cgtcgatgaa cagccgcccc tcggcgtcga agtggccgag gtcgccggtg ccggtcaggc
     5941 cgtcccgcac cttcttcccg ccgcccccgg tgtatccggc gaaccgcagg ccgccgccgg
     6001 tgtagatctc gccggtcccg ccgtccggga cctcgttccc gtcctcgtcg aggatccgga
     6061 ccgtcagccg gaacgacggc cggcccaccg tccccggcgc cgcccgcagg tcctccggcg
     6121 tcgcgatcgt cgcccagccc gtctccgtcg cgccgtacac gttgatcagc acgtcgccga
     6181 actcgtccat gaacgcctcg gacaggtgcg ggtgcagcgc cgacccgccg cacacgacga
     6241 cgcgcagcga cggcgtccgg cgccgctcgc gccgcgcggc gtccaggatc cgttgcagca
     6301 tcaccggcac cgcgaccagc gtctccgcct cgcggtcggc gatcgccttc agcacctcgt
     6361 ccgggtcgaa gcgccggaac agcacgagcg gcatccccat gccgagcccc accgacgtgt
     6421 acgcgaagcc gaggatgtgg aagagcggcg gcgccaccac gacgggcgcc cccgaccgca
     6481 cggggacgcg catcagatgg ctgagcgcgg cgggcagcag cgacgtcacc gacaggtcgt
     6541 gccgcgcgcc cttcggcgtg ccggtggtgc cggacgtcat cacgatcacg ttgctggacc
     6601 ggtccgggtt cagcggctcg gcgtccgtcg ccgcgaccag cgcgtcgatc gagtcgccgt
     6661 caccagcgcc gtccgtccag ccgagcaccc gctcgcccgc gaaccccgag tcgtccacgg
     6721 cgggcccgaa ctcctcgtcg tggacgagca gctcgacgcc ctcccgctcg gcgacctgcc
     6781 cgagctgcgt cgcggagaag tcggtgttca gcagcaccac gtcgttgccc agccgggacg
     6841 ccgccagcac ggcctcgacg aacccccggt ggttgcggca cagcacgccg accttcccgt
     6901 cgccgacccg gtcgcgcagc gccgtcgcca gcgacgccgc ccgctcctcc agctccgcgt
     6961 acgtgagcgc gccccgctcg tcgatgagcg ccgtccgccc cgggaaccgc agcgccgcca
     7021 tcgccccgac cgtcgccggg acgggcccga accgcacgta cgggaacagc agccgcgccg
     7081 cccggtcggg ccgcaccggg tgcatgatcc cggtatcgcg cacggcccgc gtcgcccgca
     7141 cgcccagact cgccaccgac cgcacccgct gaagcaccgc aatctcctca catcgcccag
     7201 ccacttacgt tgccgcgaca aacactttgt aacgcatgcc gcgccgacgg cacgacggcc
     7261 gcggtgtcgg accccgccct tagggtgccg ccatgctgtc cgtcttcctc gcatgcgagg
     7321 acccgtacgc caccgcggat ttcttcaccg ggagcctcgg ctggcgcctg gtcttcgcca
     7381 ccccgcgcgc ctccgccgac cgtctcgcct gcgtgtcgct cggcgacgcg caggtcatgc
     7441 tcagcaccga cgatgaggag ttcctgcccg cggcgtcccg cgagcaccgc ggcgccggcg
     7501 tgacggtcta cgtccgcctg ccggacaccg ccgacatcgc ggccgtccac gcccggcatg
     7561 ccgaagcggg cgtggtcacg gccccgctct ccgcccgcga atggggcgag cgggccttcg
     7621 acgcccgcat cggcggctac cgcttcctcg tcgcgcagga aggtacggtc gatggcatgc
     7681 cgtccaccgt caccgccgac gacctcgagt cggccgttcg actcgccgtg accacgctgg
     7741 agaaggcccc cgacggggcg tgggacggca aggcgggagg gctggagtgg acgtgctggg
     7801 agaccgtcga gcacctgagc gatgacctgt tcgcgtacgc ggcgcaactg ggcgcacgcc
     7861 ccgccaatcg ggaagtgccg ttcctctggg agagccgccg ccccggcggc cccgcgaacg
     7921 tcacctacgc gaaccgcgac gccgggcccg gcggactgct ggaagtgctg gaggcgtgcg
     7981 gcgcgatgct cgccgcgctg gtccggacga cgccgcccga cgtccgcgcc catcacgtct
     8041 tcggagcgtc cgaccccgag ggcttcgccg ccatggggat cgtcgagacg ctcgtccaca
     8101 cccacgacat cacccaggga ctcggcctcg cctgggaccc gcccgccgac gtggtcgcca
     8161 ggacgctcgc gcgcctgttc ccggacgccc cgcgcgacac cgccccgtgg ccgaccctcc
     8221 tctgggcgac cggacgcggc gacctccccg gccgcgaacg cctaacccaa tggcgctgga
     8281 acggcacccc ccgcctcagc tgagcgacca gacctccgga tcgtgctcca ccggcggttc
     8341 gggacgaggc gggcgttctt cgtgcggtcg cccgttgatc caacggtacg gacggcgcag
     8401 gacgcgctcg accacggccg gctccagccc cgcctcgccg agccgccgcc gcatctgatc
     8461 caggacgatg ggcagcaccg cgtcctcagc ggcggcgtcc agcaccgccg ccacgaacag
     8521 cggcgggcca tccaagtcga gcagctccgc gacctcctcg gccgtgaggc caccgccttc
     8581 tgagcggtca ccggccgggt aggcggcgcg gagcaggatc gagtacgccc ggagccggtc
     8641 gggagccgcg tacagggccg attccgccgc ctcgatcagg aagaacgcgc cgaacagtgc
     8701 ttcgcgcgtg tcgtgcagtt cgctcctgcc gggttcgcgg gcctccagca gggagcacac
     8761 gggcaggaga agggcggctc gatcgcgatg ctcggccagc ccgaggacca ggtcgtggct
     8821 cggcagccgg tgcagcatct ccgccagcag cgcgaccggc gcgttgcgtt cgcgagcgtg
     8881 cgccgcgacc tggaagaccg cgtcgcggcc ccgcaaggcg cccgcgaggc ccagccacgg
     8941 gcggaacgcc gtcgccgggg cgtccggcgg cagcatcgac aggatcgcgc cgacgtcgcc
     9001 gacgtcgccg acctcgtcgc cgaacgccat cagcaggagg atccggtaga gctcgctctc
     9061 gacctcggtt ctgtcgtacc tgtgctgggt gatctcgcgg acggtttcgt ggagcaggcc
     9121 ggtcgtccgc agcagctcac ggacctgagg gtcgcccgtc cggccgtgtg agcggcgcca
     9181 tcgcgcgtac gcggcgcgga tggcgcgcag cgccacctcc gggggcaagg gggtcgtcag
     9241 cctcgtgctc cactcgagga gcgcgcgcgg cgccagtccg gacaacaggt cgtccgccgt
     9301 gccgtccgag gccgggttga tctccaggcg gagcgcgacg tacacgccgg cgaggcgctg
     9361 cgtcggcgtg atgtccgggg acctcgcacg ccagtccgcc aggaccccgg acgcctcttc
     9421 gggcgtcacc cccatgtcgc acgccgcgtt gatgagccgt tcggcggcct gcaacgccgc
     9481 ccggacgtcg gtgagggccc gctggacggc gacccgccgc agcgtacgcc cgattcccgc
     9541 gaggcccggt ggcggtgcgg ccggccaccg ctccaaccgg acggcgagat ccgccggatc
     9601 cacggagcgc agttcggccc gcagctcctc cgccccggcc gcgctctcca gacggcggcg
     9661 atcctgctcg tccagcgtgc cgccgagcgc cgcgtcgatg agatcgagca cgccggccgt
     9721 gcgctgatgc tcggcctcca cccaagccag cagcttcgcc gtgtcggtca gcggtgtcgg
     9781 cggagggttc agcgaggccg gcggcatccc cgccagcagc ctgccggccc gtgccaggtt
     9841 ctggacggcg accgcatcag gagcaagcgg tgtccggccg cgcccggcat ccggaaggtc
     9901 gagtacgagg agccgcggcc gggcctcctc acgcgtcacc gttgcgccca gcatgatcgt
     9961 ccagggttcc ggacccgcca gccctgccat tcgccggacc aggcccgcta ccagcccgta
    10021 gtcgtccgga gcgagagcgg ccaggtacgc ccggtccggt gcggcaagca cgcccgccag
    10081 cagagcggcc aggggttcac gcggcgccgt cagtgcgtcc aactgccggg ctgcgtactc
    10141 ccgcagcccc accgcgctcc ggacctgcag cgtcgtgacc atgttgtcga ccatgtctgg
    10201 agttatccat ccaggccagt tgtgcagacc cagcgcgagc tccgcgttca ccactgacgc
    10261 tttcccgacc aacgcgtgca tggcctgcgt gctgtggccg tacgggtcgc gatccggcat
    10321 caaacgcagc accgctccga gatcgccctt ccggccgacg cgtaacgcgc ccagcgcgac
    10381 gcacttggcc gcgccttgga gccattgacc ggtcgcgatc gcgccgcctt ccagcagcgc
    10441 gctccatctc gccagctcat tcgggtccag cgacgaggcg acggggccga gcccgctgcc
    10501 gccggtcagc agccggtccg accacgtgaa cacgatctgg tcgatcccgc cgctcacctt
    10561 gtcgggagcc gtcatggcgt cccggcctca gggggccgga cgccgtcccc cggttcgcgg
    10621 cgttcgtggg acatgtcgcc tcctctacgc gggctcgtcc gtcagggcgg ccaggtcgcg
    10681 gcgggtccgg acggtgtgcg gatggtcggc gccgatgagg tgctcgcgga cgtccagcag
    10741 ttcgcggagc agcgcggcgg cctcctcgcg gcagccggtc agcgccaggt tccgggcgag
    10801 catgtggctg gtccggagcg tgtccgggtg ctggtggccg aggacgcggc ggcggtcggg
    10861 cagcaggacg cggagcagcg cgaccgcgcg gtcgcggtca ccggcctcgc cgaggttgac
    10921 ggcgaggtac tgccgggtgc ggagcacgtc gtcatggtcg gcgggcagga cgccggactg
    10981 ttcgggcagg agccgttcga ggtcctcggc ggcgccgcgc gggtcgccca cctgcccctg
    11041 cccgtgcgcg aggtactggc gggtgcgcag cgtcgcctcg tgggcggcgc ccaggacgcg
    11101 ttcctgatcc ttcaggatga cccggaggag cccggtcgcc ccgggccagt cgccggactc
    11161 ggcgagggcg atggcggcgg cctggcgttc gagcagcgcg ggcccggacg tgagcgcgcg
    11221 gttgcggccg agcccgagcc ggtcggcggt gttcgtgccg atccgctccg gctccggcag
    11281 cccggcaccg cgcatgatcg tccggagttg ccggtagagg aggtcgaggg tcagcaggtc
    11341 cggcccctcc gggacgccgt cggtgaggag ccggagaagc tgcccggtga aggcggtgtg
    11401 ccgctcgccc tccggcgcga gcgcgacctt gtcccggccg gcggacgcga ggacgtagcc
    11461 gccctcgacg tcgagcatgt cgacgacgga cgtcccgtcc gagagggagt ggtcgaaggc
    11521 gcgcgcggag aggcagcagt cgaggatcac gatcttcgtc ttcgccgggc tgtccaggag
    11581 ggcgctgcgg agcttgtcgt actcgagcgc gttgaactcc gggtatccgg cgtcgcttcc
    11641 ggggagggcg aggtacaggt cgtgccgccg gccgccggtc acgccgtgcc cgcagaagta
    11701 gacgagaagg gtgtcctcgg cctcccggaa ggcggtgcgc agggtggaac cgagccgtgc
    11761 gaggtcgctc tcgtcgagga tccggacgca gttctcgggg gcgacgatgc cgtggtcggg
    11821 gtcggtgaac acggcggcca ggtccgccag gttggcgcgg accgcgggga cgtcgggcag
    11881 gctctcgtcg gcataggaac tgctgccgag cagcaccact cgcgacttgt gggggtgcgg
    11941 cagccgcatg ctcagtcgcg ccctccgtcc agcgcccggt tcaggatcgt ctcgacgctg
    12001 cggtccttga cgttcttcgc gtcgatggtg agggtctcgc cctgctccgt cttgagctgg
    12061 atcttcaccg acgcgcggcg cggctgcgcg agccatccgc gcagggaggc ggcgaggacg
    12121 gagaccgctc cgccgctgcc gagcgtgacc agcaggatgt cggacacgtc gccgagctca
    12181 ccgggcgacg gctccggcgc ggccgggcgg acccggccct ggagttccct ctcaccggcg
    12241 agccagtcgt gcaggttctc gaggtcggcg gactgtccct gcagcgagat ggtcgcgctc
    12301 acatggcccc cagacgcttc ggcgtgacga gcgaataccg aatccttcca tgtccgcgct
    12361 cgaaggcggg acatgtcgcg ggtcctagtc cattaacgga catgagggcg ccgtttcccg
    12421 gcgggacgca gggtcagcgg cggaggagct tgaagttctc gatgacgagg acgcggtcga
    12481 tcgcgctgtc ctcgtaccag cgttcgtggc cgacgtagtt gccggcgccg ccgctcttcg
    12541 tggtgccgtc cacgtcgacg tacggatagt cggcgcgggc ggcgagccat tcgagaagcg
    12601 gctctacatg gtcgtagtag tcggggtgga gttcctggcg ggcggtgagg gcccagccgc
    12661 cgttctcgcg gggttccagc gcggcgaaga gcgccccgcc gatcttccag gccgggccgc
    12721 gctgggcgag ttgcggttcg ggggtctgga cggtggtcgg ctctccgtcg tcgtccacga
    12781 tgacctcgga gaagtcgatc gggatcgtca gttccgcggg ctgcgggccg aggccgaggt
    12841 gccagcggag ttcggcggtc tcggcgtcgg ggagatcgcg caggttgatc gccaggaaga
    12901 agtcgtagat gtcggccacg ggcggtgacc ttagcggatg tagtggaacg ccggttcggg
    12961 atgcatgagg aaatcgtggt gcgagatgtt ccacgcgtag gcgccggcca tggcgaaggc
    13021 gatcacgtcg ccgggccgca aggacgggac ggggacgtcg cgggcgaaga cgtccttggg
    13081 agtgcagagt tggcccacga gggtcgccgg tgattccggg ccgttcgcgg tgagggcctt
    13141 gaacggctgg tcgtggcctt tcgtgaccgg tgttctgagg tggtgggtgc cgccgcggag
    13201 aatgacgtag gtctcgcctc gtgtcgtttt cacgtcgagg acgtcggtga cgtaccagcc
    13261 gtggtaggcg gtcatggacc ggcccggttc gatgcgcagg cgggtgggga tgtcggccag
    13321 tccggcgccg taggcccgcc agtcgaagcg gctttccggg gaggtgtagt cgacggccat
    13381 tccgccgccg atgttcagtt cggggtcgtc cacgccatgg gttttcagcc aggggatcgc
    13441 ccattcggct atccggtggg ccaggtcgag catggcgggc gcgtccaggc cggaggcgag
    13501 atgggcgtgg acgccgcgca gggtgatgtg cgggtttccg gtgatgcggc gggcgcattc
    13561 ttcgagggcg tcctcgtcca tgccgaacgg gccgctcatg gtgagggcgg cgccgggggc
    13621 gtggagcggg aggttggccc ggagcaggac gtcggcgggg ccgcggaggc ggtcgagttc
    13681 tctcgggctt tccacgtgga gtcggtcgac gccggtggcg agggcgagtt cttcgtcgct
    13741 ctttccgggg ccgccgaagg cgaggcgtat gtccgggagg gtttcgcgga cgtgggccag
    13801 ttcgccgccc gaggagacct cgatgccgtc cacatgaggg gcgacggcgc ggaggatttc
    13861 ggcgtcgggg ttggctttgg cggcgtagaa gagttcggtg cggccgagcg ccgcgcggat
    13921 ggattccacg tgcgtttcca ggccgggcag gtcgtagacg taggcgggga agcggtcgag
    13981 gtcgcggacg tcgtcgaggt tcacagcgga aggggcgcgg agagcgggtt gggggcgggg
    14041 acgtaggcgg cgccgcggtc ggcggaacgg gaccagcggg tgcgcaggtt cgccttcgcg
    14101 ggaagcggga cgccggcgag gagcgccctg atctgcgggt ggtggtcgag gtgcgcgaga
    14161 tgcgcccggg ccgctttcca caggtcggct tcgagcgcgg gatgcaggtc ggcgacggcg
    14221 gccgccgttt cggtgaggtg gttgacgagc aggcagtaga cgacgcggtt ccagccgtgc
    14281 gcgggcgtgt aggtgaggct ctcggcgacg cgggcgggca ggtgcgacag gtcccagcgg
    14341 ccggcggtga gcttggtccc ttcgaggtcg cggaacgcgg catggaccgg catgccgtcc
    14401 tcgtcgacgc agatcaggac gttctgcagg tgcggctcca ggacgacgcc gtgttcgagg
    14461 aacgcgcgga gcaccggcgg cgcgacctgc gcgacgtagg cgttccacca ggcgagggcg
    14521 ccgtcggcgg tcgacagggc gggcaggtcg ttcaggaggg tgttgtacgg gtcggccagt
    14581 gcccccgcca aaagcggtgt accgggaagg tgcttcacgc cctgccggac gatgacgccc
    14641 aggccctcgt agaggcggcg gtcggcgagg gcgacgctgc ggtaggcggg ctccgcgagg
    14701 agcgtcgcgc ccagcgacgt gaagaccggg cgcaggaggt cgttcagggc caccgcaccg
    14761 gacagctcgt accaggcgtt cttgcggacg cagttggtga tgcgcacgtc caggctgaac
    14821 ttgcagaaca ggtcggcgtc aggcaggtac acagtgcgga cggacgacgt cggtacggcc
    14881 tcgacatcgg acggccccag atcacgcact agcccccgcg ccagtgcgtc ctgtagcagc
    14941 gggttcccgg cgagcagcga gaactgccac ggatgcaccg ggagcgtccg gcagccgggc
    15001 acggacggcc cgcccagcgc cgcgaacgcc tgcgggtcgc cctcctccgc gacggcgtcg
    15061 tcccgcacgg cgagccagcg cggccggaac cgggccctgg tctcgggcgc gtagcggagc
    15121 cactcggcgg gggagccctg ccgggacttc ggcgacgggt ggaagcggtg gcccgcgacg
    15181 agcgactgct ccgattcgag gtaccggtcg tcctgggggg cgtgcctggc ggcgatgatg
    15241 gcggcgagcg cgctgtggct gtcgccgacc tgcgcgagga actccgggtt gggctgcccg
    15301 gtcgccagtt cgagctcgcc ggcgacgagg tcggcgaggc ggtcccagga ggcggggatc
    15361 cacgcgtcgc cccgccgctc ctcgtacggc ggcgcgaggc ggtacgtggg gccggcgggc
    15421 gggcgggcga ggccggtgcg cagcacgacg ccggcgcgcg gcagccgggc gacgaggtgc
    15481 gcgccgtccg gccgcacctg ctgctcgggg ccgcacacct cgcggatcag gcagttgagc
    15541 agcgcggtgg aggtggcgtc gtcggccgtc agggcccgtt cggtcagaag cacgtcgcat
    15601 cccgtaggta gttcggcccg ggcgggccgt agtgcttgtt gatgtcggcg gcgccggtcc
    15661 tggccttgtc gacgagggtc ccggcggtga ccatcgcctt gcccggcagc gcgtccgcgt
    15721 cgagcgtgcg ggagcgcagg aacgcgtcgg gcgggccgag cgccgcgtcg agccggtcgc
    15781 ggatcagggc gcggccggtg cgccagggca gcaggccccg ctcggcgagg ccgagggcgg
    15841 gcgccgcggc gcacaggtgc agggtgatcg tgacgaacac gcgggcgagc gcgtcggggt
    15901 cggcggtgac catccgccgg tcgacgaggt cgcgggggtc ggcgccgggg gacgggccga
    15961 ggcgcgcgcg gagccgggcg gggttgatga gggcgccgtc gttgtccttg acgagcaggc
    16021 gcggcggccc gtgcccgtcc aggacgagcg cgacgttctg ctggtgggcc tccagcgcga
    16081 tcccgtagcg gaacagcgtg acgttccatg cgaacagcgc cgcaaggtag gtgtcgaaga
    16141 gcggctcgac gtcccagcgt tctatgacat ggcccttgtc cggggccttc gcgaccaggg
    16201 cggcgatggg gacgatgtgc gcgcgcgccg tttccgctgg gaagcgtcgc acgaggtagg
    16261 cgaggagcgg gttgtcggcg tgcccgtagg tctgctcatc ggccagcagt acgggaaggt
    16321 gcggttcgcg gtcgaggacg cgccgcagga cgcgttccac gagcgcgccg tccggcagcg
    16381 tgccggggac gatcgtgcgg cggttgcgca gccccagcgt gctcgtcggt aacgggacct
    16441 tcacgtgctc tagcggcgcc gccgcgacgg tccgcatcga cagggtcggg gagacctgga
    16501 ggtacggctc cggggccatc gtcgcggccg gttggtcgcg caccagccgg acggccagcg
    16561 ggtggacggg gaacagcgcg tccgccgacc gcagccccac gtcggcgggg gagggccacc
    16621 acaccggcgg ctcgcccacc agggtcgcgc cgcggacgga cgcccagcgc agcgggaacg
    16681 acggcgcgaa ctccggggcg tagcggctca ggtccgccat gctgagccct gcgcggctgc
    16741 ggctcgtcgg gtggacgggg tggtcgttgt aggcggcgag gctctcgtag aacgtccctg
    16801 ggccggtcct cagcgcgtca ggtatccgcg ctaagcgccg gtgtacggcg ggacgcgcgt
    16861 cgttatggag cttcaccgtg gcgagcgcgt ccaggcactc gcgctcgaac gcctcggtgt
    16921 cgtcccgggg atcggccagg tgacgcacca gcgcgaagac gtcccgtagc gcgaggttct
    16981 gcgacgggtc gacgcgcagt tcggacagga aggcggggtc ggcgtccacc agcttcacgg
    17041 gacggcccgg cagcgcgagc gtccggttct cgacgaaccg ccgcacgccc gcgtagtcct
    17101 cgcggatcag ggcgtccagg acccgggccg ccagccgtcc ctcgatgtcg ggaaccgtca
    17161 cgcgatcgtc cactcgtggg cggagcggaa gcgcgccacc gcggcctcca cctcgtcccg
    17221 ccccgggccg atcgcgcgga cggtccccag gtagtcgcgg ttcgtgcggg tgagggcgac
    17281 cgggtcgccg acggcgcgct gcgggaggta ggccagccgc acggcgccgt cgtccagctc
    17341 catggggccg ggggcggcgc acaggacgcc tgcgcggtcc gcgatgacgg cctccgcgac
    17401 cgcatgcccc cgcaccgccg gaacctccaa cgccggcggc tccccgaggt ggacgcccag
    17461 gatccgctcg aacagcggga tgccgagcag atcggccatc aggaagtcgc agtggtcgcc
    17521 gatcagccgg tagttcacct cgatgatgcg ggcgcggccc tcgtggacga cgaactcggt
    17581 gtggcacgcg ccgaatccga cgcccagcgc gtcgagctgc gcgaggatct gcggcgtctc
    17641 cggaggcggc ggcgcccact ccagccgctc ctccacgaag aacggcggcg gcgacacggt
    17701 cgtccggtac gagccgagga cgcgcagctc acggccgtcg ccgagcgtct ccagcgtgtg
    17761 cagccgcccc ggcaggtact cctcggcgac cagcgggtcg ctccggcgcg ccgcgatgtc
    17821 ctcgcgccgc gtctccagct cccgcgcgtc gtggacgagg aagacgtcct cgctggcgac
    17881 gccctcgcgc ggcttcacga cgagcgggta cggcgcgtcc ggcggcacgt ggaaggcgtc
    17941 cgccgagaag acggggtcca gcgcggcgag atggcggcgc atcaggccct tgttcttcgc
    18001 gcgcgccgcg gcccgccagt ccttgccggg cagcccgaag taggcggcgg cgagcgcggc
    18061 gggcacctgc aggaagtcgc tgttggagaa gatcccggcg ggctcgccct cgacccggtc
    18121 gatgatgtgc cggaagtcgg agacgtcgca ttcgacgacc cgtccggcgg cgtgcgcgtg
    18181 ggcggcgggg cggtcggtga gcagcaccac gtccagcccg aggcgcgcgg cggcgggcag
    18241 gaacccgtgc gtcaccgagt cggtcgcctt gccggcgacc aggtagaggg aggcggccac
    18301 ggtcggcctt tccagtgagt gtgtgaggta agccttgcct aactcgcaac cgtcaccata
    18361 gtggccgggc aggggcccgc aggcaagaac gatggcatcg cgtgtcccgc cgcgtccggc
    18421 gatccgggag gatggcccca tggatctcgt cgagcggtgg gtcgcgctgg ccggccccca
    18481 gacccggcac atcgggacgg agctggacaa gcggtacggc gaaccgcacc gcaagtacca
    18541 cacccgcgag cacctcaccg ccgtcctcga cctcgtcgac gagctcgccg ccgacgccgc
    18601 cgaccctgag gccgtgcggc tcgccgcctg gttccacgac gccgtctacg accccgagcg
    18661 cgccgacaac gaggagcgca gcgcccgcct cgccgcccgc atgctcgccg acaccgacct
    18721 gcccgccgcg acgatcgacg aggtcgtccg gctcgtcgag ctgaccgtca cccacgcccc
    18781 cgggcccggc gaccgcaacg gccaggtgct ctgcgacgcc gacctcgccg tcctcggcgc
    18841 cgaccccggc cggtacggcg cctacgccgc cgccgtccgc gaggagtacg cgttcgtccc
    18901 cgaggacctc ttccgcgccg gacgcgccga cgtcctcaac ggcctcctcg cgctcccgca
    18961 cctgttccac accgccaccg cccgcgaacg ctacgaggac cgggcgcgcc gcaacatcga
    19021 gacggagctg atgctcctca acgcctagac cccgacgcct agaccgccgt ggaccggcgc
    19081 cggaccgcct tccgccgccg cagccccgca cgggtcagcc gcaggagcag ctcctggcag
    19141 ccgaccgcct ccgctccctg cgccaccgcc gcctcgtaca gctcggacgg cacgtcgtaa
    19201 tggtcccggt cgaacgcccg caccggcatc ccgagctccg ccgcgaacgc gtgcagctcc
    19261 tcgtacgaca cgtcgctcac catgtgcgac cacacgcgcc cgcgcgccgg ccacagcggc
    19321 ggatcgatga ggaccaaagc tcctcctggg gggccggcgg aacaggatcc cttaccgcgc
    19381 ctgacagtac gacacacagt gcaaaggggc atgcagttga cttcctcccc tcgtcgcgag
    19441 gggattccta cggctcgcgc cgtgggagtt tctgcttcgc agccgactgc ggaagggagg
    19501 tcccttgccg tctgacatca gctccacaga catcgccggg ggtgtccccg gctacggctc
    19561 gaccagccgc aaggatgttc ttggccgcgt tgtggtcccg gtcgtgccgg gtgcggcagc
    19621 ccgggcacgt ccagcgccgg gtggaaaggc tcagctccgc gagcaggtgc ccgcaggcgg
    19681 agcaggtctt ggaggagggg taccagcggt cgatcaccac cagggtgcgc ccggcccgct
    19741 cgcacttgta ctccagctgg cggcggaact cgccccagcc gcagtcggag atggcacggg
    19801 cgagcgtgcg gttgcgcacc atgccggaga cgttcaggtc ttcgatgacg atggtgtcgg
    19861 ctcgacggac gaggccggtg ctggtgcggt gcaggaagtc ggcacgggcg tcgcggacct
    19921 tgcggtgagc gcgggcgacc ttggccttgg ccttgcgacg gttgttggac ccgggccggc
    19981 atcgggccat gcgccgctgg taacgggcga ggttccgctg cttcttctcc agatgcctgg
    20041 ggttggcgat gcggtctccg tcggaggtca ccgcgaagtc cttgaccccc aggtcgacgc
    20101 cgatctggtg ttcggcggcc ggcaggggga cgcgctcgtc ggtgtcgacg gcgaaggtga
    20161 cgtaccagcg gccgtcgcag tcccgcgaga tcacgaccat cgtcgggttc agcgtcacca
    20221 ggtccacgtc gtcgaaggac cagacgaacg ccaggggcgc ggtggtcttg gccatccgca
    20281 gttcgccgtc gcgcatgcgg aacgccgagc gggtgtagtg cgcggactgg cgggagttcc
    20341 ggttcttgaa acgcgggtag cgggcgcgtc cggcgaagaa gttggcgaag gcggcatgct
    20401 ggtggcgcaa cgcctgctgc agcggcaccg aggacacctc gttgaggaac gccaggtcct
    20461 cggtcttctt ccatgccgtc agcgccgcgt cggtctcctt gtaggagccg cggttgccat
    20521 cggcatgcca ggcgcggtgc cgctcggcca gcgtcttgtt ccacaccagg cgcacacacc
    20581 cgaacgtacg gttgaacacg gccgcttgct cggggtcggg gtaggcccga cacttgtacg
    20641 ctgtccgcac gaccatcatt tttacatatc gggcttacgg ctgtaagaga tctcgggtcg
    20701 gtggaccccg ccgccggtgg gtccaggctg taccgggccg cctcggacgg agcacgagtt
    20761 ccttcccgtc ctgaaggccg gggtatcttt cggaggatca ggtgaacgac ccagttcagg
    20821 agatagtcga ctacatcgag gccggccgcg accggttcat cgccgacctc aaggaatggc
    20881 tggcgatccc gtcggtctcc ggggaccccg cctacgccac cgaggtgcgg cgctccgccg
    20941 agtggctcac cgggtacctg cgcggacagg gcttccccac cgtcgagacc tgggagacgc
    21001 cgggcctccc ggccgtgttc gccgaatggc ccgccgccga cccgtccgcc cccaccgtcc
    21061 tgatctacgg gcaccacgac gtccagcccg tcgaaccgct ggacgagtgg gacaccgcgc
    21121 cgttcgagcc cgtcgagaag gacggccggc tcatcggccg cggctcgtcc gacgacaagg
    21181 gccaggtgtt cttccacacc ctcggcatcc gcgccggcct cgccgcgtcc ggcgccgacg
    21241 ccccgcccgt caccatcaag ctgctggtcg agggcgagga ggagtccggc tccgtgcact
    21301 tcgccggcct gctgcgcgag cgccgcgacc ggctccgctg cgacgcgatc gtcatcagcg
    21361 acaccaccat gtgggccgcc gacgtcccgt cgatgtgcac cggcatgcgc ggcctcaccg
    21421 aggccgaggt caccctccgc ggcccgtcct ccgacctgca ctccggctcg ttcggcggcg
    21481 ccgtcccgaa cccgctgcac gccatggcga cgctgatggc cgcgctgcac gacgccgacg
    21541 gccgcgtcac cctccccggc ttctacgacg acgtcgtccc gctcaccgac gaggagcgcg
    21601 cgctgttcgc caagctcccg ttcgacgagg cggaatggct gcggaccgcc ggcggcagcc
    21661 gcgccgccga cggcgagaag ggctacacca ccctggagcg cgtctgggcg cgcccgaccg
    21721 ccgagatcaa cggcatgtgg ggcggccaca ccggccccgg cggcaagacg atcgtccccc
    21781 gcgaggcgca cgccaagatc tccttccggc tcgtcgccgg ccaggacccc gccaaggtcc
    21841 agcaggcgtt ccgcgactgg gtcgccgcca acacccccca cggcgtcgag gccgaggtgc
    21901 acatccccgg cggcggcgtc cggccctgct tctcgcccat cgactcgccc ggcgtcacgg
    21961 ccgcccgccg cgccatggag cgcgcgttcg gccgcgaggt cctgttcacc cgcgagggcg
    22021 gcagcggccc cgaggccgac ctcgccgaca tcctcgacgc gccgctgatc ttcgtcgcgg
    22081 tcgggctcga cgacgaccgc atccacgcgc cgaacgagaa ggtcgagatc cccctgctgc
    22141 tcaagggcgc cgaggccgcg gcctacctgt gggaagaact cgccaccgca ctccgctgaa
    22201 cagggagtcg ggtacgacgg gagaaaggag cccgatgacg gtgaccgaag gaccgctcga
    22261 atggctcgcg ctcgcgcgcg gcacgctcga ccgcgtcgcg ctgaagcggc gcgacgacgc
    22321 atggctcgcc gccgcgtggg ccgacccggc gacgcgggtc ctggtcgtcc aggacgggcg
    22381 gacgctcgtc acctacacgc ccgagccggc gctcgcgttc gtcgcgcccg cgcaggcccc
    22441 ggacggcgac cggtggctgc tcggcgtcga cgacgccggc accgcctact tcggcgtccc
    22501 cggtgagctg cccgcgctgg acggcgccga gcccgccggc ctgcgccgcg tcggcgcgct
    22561 gctcgccgac cgcgacgccg gcctgctcac gcacgccgtc gcgctcgagc actggcacgg
    22621 caccaaccgg ttctgccccc gctgcggcgc ggagacccgc gtcacctccg ccgggcacgt
    22681 ccgcgtctgc tcgcaggacg gctcccagca cttcccccgc gtcgaccccg ccgtgatcat
    22741 gctggtcacc gacgccgacg accggatcct gctggcccgc ggcccgcagt ggcccgccga
    22801 ccgccgctcg atcctcgccg ggttcgtcga gcccggcgag tccctggagc agaccgtcgc
    22861 gcgggaggtg gaggaggagg tcggcctcgc cgtccgggac gtccgctacc tcggcagcca
    22921 gccgtggccg ctgccgcaga gcctcatgct cggcttcacc gccaccgccg acggcaccct
    22981 cccgctgcgc cccgaccccg aggagatcct cgacgccggc tggtacaccc gcgacgagct
    23041 gcgcgccgcg atcgaggccg aggagatcgt cgcccccggc ccgctctcca tcgccgccca
    23101 gctcatcatg cgctggtacg gcggcgaact ccccagaatg ccggcgttct gacaagcccg
    23161 tcgggcacgc cgtggagacg ggacgagccc ggcgactcgt gggagtcgcc gggctcggtc
    23221 gttcgcaggg gatcaggtga gggacgcgag cttcgccttg accgccttcg cgctcgggtt
    23281 ggtcgcggcg gagccgtccg ggtagacgat cgtcggtacc gtctggttgc cgccgttgac
    23341 gctcatcacg aactcggcgg ccttcgggtc gcgctcgatg tcgatctcca ccatctcgat
    23401 cccgtcgcgg gccagctggc tcttcagccg ccggcagaac ccgcaccagg tcgtcgtgta
    23461 catggtgagc tggccggtcg ggccctcggc ccggtcggtc gtcggcgtcg ccatcggtac
    23521 gtcgtctccc tcgttcgttc ggacgatctg tgctctcgcc tcccgaagaa cactagatac
    23581 ccgtccggca ttccgcgagc gccggcacgg ccgccaccgg cgcggccgtc cgtccacaat
    23641 tcgtgtggcg ggcggatacg gtcggggcgg gctgggagta tgggggaatg ttggctgagt
    23701 cggtgctgga ggggctcgac cccgaacagc gggaggtcgc cgaggcggtg cagggcccgg
    23761 tgtgcgtcct cgcgggcgcc gggacgggca agacgcgcgc catcacgcac cggatcgcgt
    23821 acgcgacgct cacgggcgtg gtgacgccgc agcgagtgct ggcggtgacg ttcaccacgc
    23881 gcgcggcggg ggagctgcgc agccggctgc ggcagctcgg cgcgcccggc gtgcaggccc
    23941 gcacgttcca cgcggcggcg ctgcgccagc tcagctactt ctggccgcgg gtcatcggcg
    24001 gcgacccccc gaagatcatc gactcgaaga tcgggctggt cgcggacgcg gcgcgcgcct
    24061 gcgggctgtc gctcggccgc accgagatgc gcgacgtcgc cggcgagatc gagtgggcga
    24121 aggtcaccca gaaccgcccc gaggactacc cggccgcggt cgtgcgggcg gggcgccggc
    24181 cgtccaccga ggcggtggac gtggcgcgcg tctacgcgat gtacgagcag ctgcggcgcg
    24241 agcgcaacct gctcgacttc gaggggatgc tggagctgac cgcggccgtg ctcaccgagc
    24301 accgcgaggt cgccaaccag gtccgcgagc agtaccggta cttcgtcgtg gacgagttcc
    24361 aggacgtcaa cccgctgcag aagatgctgc tggacacctg gctcggcggc cgccacgacc
    24421 tgtgcgtcgt cggcgacccg aaccagacga tctactcctt caccggcgcc agcccgtcct
    24481 acctgctcgg cttcacccgc gagcacccgg acgcgaaggt cgtgaagctg gtccgcgact
    24541 accggtcgac gccgcaggtc gtccggctgg cgaacggggt gatcgaccag gcgaagggca
    24601 cccggcaccg gctggagctg gtcgcgcagc gcgagaacgg ccccgagccg gtgttcaacg
    24661 agtacgacga cgaggtcgcc gaggccgacg acacggcgcg gcgggcccgc aagctgatcg
    24721 acgagggcgt cccggcccgc gagatcgcgg tccttttccg gatcaacgcg cagtcgcaga
    24781 cgtacgaggc ggcgctcgcc gcggtcggcg tcccgtacgt gctgcgcggc gcggagcggt
    24841 tcttcgagcg gcccgaggtg cgggaggcgg tcgtgcggct gcgcggcgcg gcccgcgcgg
    24901 gcgccgacgc cgagaccgac gggacgggcc tgatcatgac ggtccggcac gtgctgtccg
    24961 gcgcggggtt ctccgaccgg ccgccggagg gcgccggcgc ggcccgcgcg cgctgggagt
    25021 cgctcgcggc gctggcgcag ctcgccgagg acatggccgc cgacgatccg aaggcgggcc
    25081 tgcccgagtt cgtcgccgag atcgaggagc gcgccgcggc gcagcacgcg ccgccgctgg
    25141 agggcgtgac gctcgcgtcg ctgcacgccg ccaagggcct ggagtgggac gcggtgttcc
    25201 tcgtcggcct cgcggagggc accctcccga tcgtctacgc caagacgccc gagcagatcg
    25261 aggaggagcg ccggctcctc tacgtcggtg tcacgcgcgc gcgcgtccat ctgacgctgt
    25321 cgtgggcgct ggcgcgctcg ccgggcgggt cgcagatgcg ccgcccgtcc cggttcctcg
    25381 acggcctgac cggcaagacc accacgcaca cgcccgcccg cgtcgaccgc accaagcggc
    25441 gcgtcaccaa gggcccgcag ccgtgccggg tgtgcggccg cccgctgacc gccgccgtcg
    25501 agcgcaagct cggccgctgc gaggactgcc cgtccgagct gaacgaggag ctgttcgtcg
    25561 cgctgaagga ctggcgcgcc gaggtgtcgg cggagcagcg gatcccggcc tacgtggtgt
    25621 tcaccgacgc caccctccag gcgatcgccg agaaccggcc cgactcgatg gaggacctgg
    25681 cccgcatccc cggcgtcggc aaggtcaagc tcgaccgcta cggcgaagcc gtcctgggcc
    25741 tctgcggcac ctgaccggcc cgtccggcgg cgcgcccggc caggggcgac ccgggggtga
    25801 gacaccgctc acacgggtgt atagggaaga ctggcggccg tgagcgattc cctgaaggca
    25861 ctgctcgatc tgctggatct cgagcagatc gagaacgaca tcttccgcgg ccgcagcccc
    25921 gaggagcgcc ggcagcgggt cttcggcggc caggtggccg ggcaggcgct ggtcgccgcc
    25981 ggacgcaccg tcccggtgaa ccggccggtg cactcgctgc acgcctactt catccggccc
    26041 ggcgacccgc tcgtcccgat cgtctacacc gtcgaccggg tccgggacgg gcggtccttc
    26101 acgacccgcc gcgtcagcgc cgtccagcac ggcaaggtga tcttcacgct ctcggcgtcg
    26161 ttccaggtcg tcgaggacgg ccccgcgcac cacgcgccga tgccggacgc ccccgacccc
    26221 gagacgctgc cggactcgct gacccggctg accccgctgt tcggcgaggc cggcgcccgc
    26281 gcgttcgtcg agcggcgccc gttcgacgtg cggcacgcga ccccgctgac ctgggaggcg
    26341 gccaaggacc cggcgctggc ctcgccggag tcggtggtgt ggctgaaggt gctcggcgac
    26401 ctgcccgacg acccgctgct gcacgtgtgc ctgatgacct acgcctcgga catgacgctg
    26461 ctcgacaccg tcctgctcaa ccacgggctg gcctggggcg acaagcggac gatgggcgcg
    26521 agcctggacc acgcgatgtg gttccaccgg ccgttccgcg ccgacgactg gctgctgtac
    26581 taccaggaca ccccgttcgc gggcggcgcc cggggcctcg cccgcgggca ggtgttcaac
    26641 cgcgccgggg agctcgtggt gtcggtgatg caggagggac tcgtccgcgt gtccgactcc
    26701 ggccgggagc gatgacggga cgcgtcgcgt cccgtatgag atgatcgtct tgtaaggcgc
    26761 tcccgggagt ttcgacgccg cgcgagcggc gccggttccg gggaacgagg gtgaagtcac
    26821 ccacaaaacc gcaggtcaaa aataccttga ttgcttcggt gaagtccccg tacgctcgtc
    26881 gcgagcaatc aaccggccga ccggtgtgga tcttgaatcc gccggccccg gcccgaggag
    26941 ccagagaggt ggtgtgcagt ccggtgatca acacgtcgat gaaatcgctg tcgtcctgga
    27001 ccgcggcctg ccccggcacc tcgaccgcgt atgccgtctc gtgtgtccgg accccgctcg
    27061 gcgtgaagcc cggcggaccg gcgcgtcacg gcgtcgccct gtcggccaat gcggccggag
    27121 agcggctccg cgtcgacggc acccgtctgc gcgatctacg tgatctgcgc cttgagcagc
    27181 gaatccagga cgagcagggg tggagtgtct tcgcattcga aggcatgacg tcccaggctc
    27241 cggccacggc ccacatgggc gccaccccgg cgggtggcgt gtcgggtccg tatccctgga
    27301 ggcgaccggt ctagcaagac accggcgagc ccccaggccg cggatccgat accggatccg
    27361 cggccttctc ttttgcccgg acgacccaac cgacacgccc gttgagatcc aacgagagga
    27421 accagggtga ctgtgatgca gggggctctc gccatcagcg aggaggacct cactcttccg
    27481 tgccggaccg accccgagct gttcttcgcc gaggcgcccg ccgacgtcga gctcgccaag
    27541 gcgctgtgcc tggagtgccc gctccgcaag gagtgcctcg ccggcgcgct cgagcgcaag
    27601 gagccgtggg gggtgtgggg cggcgagctg ttcgtccgcg gcgtgatcgt cgcgcgcaag
    27661 cggccccgcg gccgcccgcg caagcacccg ctcccggacg aagcggccgt gtgaggccct
    27721 gatgccgacc gcaccgacgc tcagccggat cgaacccgca ggcgcggtcc ccgcgcgggg
    27781 accccgcctg cgggcggcga gggagaacga gatgacattg ctcagccagg acctgtcccg
    27841 ggagcgaata cccgcgaccg cgcccgacgc gctggccgtc cgcgtgcgcg ccctgcggcg
    27901 cgcgcgccgg gaggcgcaga cgagggcgtc gcgggtgcgg cgcgtgctgc tcgcgccgac
    27961 ctcgtcccgc gactgacgac cacctccggt ccgccggtag caggccgtcc gcccgccgct
    28021 tcttggatgg tttcggcggg cgccaccgga tgatcgggac gcgcctcccg gcggacacac
    28081 cggtgcaccg gcccccactt gccggacgca ccgcgacggg ccccgcccgc gcctcatcag
    28141 cgcgggcggg gcccgtcgtt cttccaggcg cccgtcagcg ttccggtggg gggacgaccc
    28201 cccacgcccc ccggcaaggg cggctgaccg tcgccttccg ctccgctgga gctccgctcc
    28261 aggcgccggt cagccggtga cgagttcgcc gtcctcgtcg tcggcgaagc cgggcaccca
    28321 cttcagcgac tcggcgcggg ccgggatctc gcactccagc tggcacagca cgccggtgcc
    28381 cgccgacagc acccggtgga tgatcacgta ctcgggcggc aggttgagct gccggacgac
    28441 gttggtcggc cgcaggtcgg tgacgcgggc ggccatgtcg cgcagccact cgcggttgaa
    28501 cttgaacgtc tcggtgacga acggctcggt gatcggtgcg aggaacgcct gcagcgcctc
    28561 ggcgtcgacc tccacgccct cgcggatgaa gtcctcgtcg cgcagggcgt cctcgatctc
    28621 gtcgatgtcg gccatcgtgc cgatccgcag cagcagcccg agccgcttct ggaagccgcc
    28681 ggggatgcgg tcgacggcgc cgaagtcgag gacgccgagc cggccgtcgt ccagcagccg
    28741 gaagttgccg gggtgcgggt cgccgtgcag catcccggac cgcttcggcc ccgacagcag
    28801 gaaccggcag tacagcagcg ccgcgtggtt ccgggtgtcc tggtcgccgt cgctgatgat
    28861 cttcgagagc ggggtgccct ccatccactc ggtgaccagc acgtcgccgg actgggcgat
    28921 gacctcgggg atgtagaagt cggggtcgtc ggcgtaggcg tcccggatga tcgtctggga
    28981 ctcggcctcg atcgtgtagt cgagctcctc gacgacccgt tccttcagct cggacagcat
    29041 cgacttgacg tccaggcccg gcatgaggat gccgaacagc cggccgagcc gggcgagctg
    29101 gttgaagtcg ctgatcagcg ccttgccggc gccggggtac tgcaccttca cggcgaccgc
    29161 gcggccgtcg gaccacacgg cgcggtgcac ctggccgatg gacgccgcgg cggcgggctt
    29221 gtcgtcgaac gactcgaagc tgtcgcgcca gtcctcgccg agcgcctcgg cgagcacctt
    29281 gtggacggcc gaggcgggca gcgggggagc ggcctcctgc agccgggtga gggtggcgcg
    29341 gtacggcccg gcgatctccg gcggcagcgc cgcctcgaag atcgacagca tctggccgag
    29401 cttcatcgcg ccgcccttga gctcgccgag caccttgaac agctgctcgg cggtgcgcgt
    29461 ctggatctcc atggcgacgg cctcggcggg ccggccgatg gtccgcttcc cgatgccgag
    29521 ggcggtgcgc cccgcgaagc cgagggggag ggacgccagc tttgctgacc gcgtcaccgc
    29581 gcggcgggga agatcgctca cgcggaccat tgtcggtgat ccgctgtcgt tcgcgccaca
    29641 acgaccggga ggcaaatccg gagtcgcggc ggaacggaac gctgtgacct gcacttccgt
    29701 ggtaagtgtg cgctttctca cgcatctcgc gcggcccggc gcggccacga tccggcccct
    29761 ggagggggcg cgtgaacccg gcgggggcgc cgcacggtac ggtgcggagc catgtccgga
    29821 gaacagcccg aggtgctgcg ggtcgagcgc cgtcccgacg gcgtcgccgt cctgacgctg
    29881 aacgaccccg gccggcgcaa cgcgatgtcc gacgagatga ccgccgcgta caagcaggcc
    29941 atcgcggacc tgcgcggcga ctccgggctg cgctgcgtgg tgctcaccgg ggccggcacc
    30001 gcgttcagct ccggcggcga cctctcctgg ctggccgaca ccaacagcgt cgccgtcccc
    30061 gcgctccgcg accgcatgct cgagttctac cggacgtggc tgacgatccg gagcctcgaa
    30121 gtccccaccc tcgccgccgt caacgggcac gccgtcggcg ccgggctgtg cctcgccctc
    30181 gcctgcgacc tgcgctacgc cgcggaggac gccaagctgc tcgccccgtt caccgcgctc
    30241 ggcctgcacc ccggcatggc cgccacctgg ctgttccccg aggtcgccgg gctgccgctg
    30301 gcccgcgaga tgctgctggc cggacgggtc ctcaccggcg ccgaggccga gcggaagggc
    30361 ctggtcaacc aggcgttccc gcgcgcggac gtgctcgccg agaccttgaa gatcgccgag
    30421 cggatcgccg cgaacgcgcc catcgccacc cggcttacca aggtcgccct cgcaggcggc
    30481 ggccacgcgg acatggacgc cgcgctgcgc tgggaatccc ttgcccagcc cgtcaccatg
    30541 gcgtccgagg acatgatcga ggggctgacg gcccagcggg agaagcggcc cgcgcgcttc
    30601 accggcgctt gagcaggttg tggaaagccc ctgaccgtcg accaaaagat gggctctgac
    30661 ctgcgctgac gtcaaacacc ccctgtggag gacgcaaaat tttgggtacg gttgcgccgt
    30721 gccccctaac gttgaggtcc gccgcagcac caggcgccgc cggaccgtgt ccgcctaccg
    30781 cgacggggac aaggtggtgg tgatggtgcc ctccaggctc agcaaggccg aagaggagca
    30841 gtggatcgcc accatcctgg aacggctgga ggagcgcgaa cgccgccgcc gcccctccga
    30901 cgccgccctc cagtcgcgcg cccacgagct gtcccgccgc tacctggacg gccgcgccga
    30961 cccggtcagc gtccggtggg tcgacaacca gcgcacccgc tggggctcgt gcacccccga
    31021 cgacggcacc atccggctgt ccacccggct gcggggcatg ccgtcctggg tcgtcgacta
    31081 cgtgctggtg cacgagctgg cgcacctgct gatcccgggg cacggctccg acttctggca
    31141 gctcgtcggc aactacccca a
//
