LOCUS       NZ_CP053892            24672 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7977086
            Orig. end                         :: 8001758
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..24672
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="21"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24672
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24672
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14672](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14672
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    111..124
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            722..1360
                     /locus_tag="ACTIVE_RS35865"
                     /old_locus_tag="ACTIVE_7197"
     CDS             722..1360
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS35865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7197"
                     /product="hypothetical protein"
                     /protein_id="WP_173099140.1"
                     /transl_table=11
                     /translation="MEWTPRQRDHKALGAFLTLCVIGAIYLAIANRGFAWVLDWRMSAL
                     LFALSGLGALFGLIEWRIDCGADWLRHAWRWVKLYELTEIEVVKAQELRLKDRGEREVK
                     IELKEFGKNQELWDLVYNGIQHSYHYGGATADSGTRLSLSLYKPVLVPLTGFEDESEIV
                     EHDVDAAVRDFLAWEPDSPEDRARMRKREAELREAWWPGGGDEEPPPGG"
     gene            complement(1362..2204)
                     /gene="ddaH"
                     /locus_tag="ACTIVE_RS35870"
                     /old_locus_tag="ACTIVE_7198"
     CDS             complement(1362..2204)
                     /EC_number="3.5.3.18"
                     /GO_function="GO:0016403 - dimethylargininase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ddaH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854129.1"
                     /locus_tag="ACTIVE_RS35870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7198"
                     /product="dimethylargininase"
                     /protein_id="WP_173099141.1"
                     /transl_table=11
                     /translation="MTVMPATEPSTPRRTALRRHYLMCRPDHFAVTYAINPWMDPAAGA
                     DAGRAVEQWEALRAAYAALGHEVSLIDPIEGLPDMVFAANGALVVGGRAYGAKFTFPER
                     AAEGPAYADWLRKNGFPDVLPPEHTNEGEGDFLTLDHVILAGTGFRTDIAAHQEAQEFL
                     GRPVVTLRLVDPRFYHLDTALFPLGGSNVAYYPGAFSPGSRAVLERLFPDALIAGEADA
                     AVLGLNAVCDGRNVVINAEAAGLIGTLREHGYEPVPVDLSELRKAGGGPKCCTLELRA"
     gene            complement(2366..2980)
                     /locus_tag="ACTIVE_RS35875"
                     /old_locus_tag="ACTIVE_7199"
     CDS             complement(2366..2980)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="ACTIVE_RS35875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7199"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_173099142.1"
                     /transl_table=11
                     /translation="MGGTEEDRLIETATRIFAELGYDGTSLQMIADAAGYDIGAVHGIA
                     ATKADLYRAVMRNADESEEAALREALAGFTADRGGVIMLADAYLDFYVSHPQVLALWQH
                     RWMGDAADLPDLEEIYTRPLSRDIADTVRDLVPPDVDPDYLIWSVVWCVYGFLTGGLVR
                     SGPDEAPQRHTPSSAPCPHDDIAGFRTFLHTMLDHMFTPLP"
     misc_feature    2984..2997
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.55"
                     /tool="antismash"
     gene            complement(3070..3396)
                     /locus_tag="ACTIVE_RS35880"
                     /old_locus_tag="ACTIVE_7200"
     CDS             complement(3070..3396)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889224.1"
                     /locus_tag="ACTIVE_RS35880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7200"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_173099143.1"
                     /transl_table=11
                     /translation="MTARIGRDELKAAIDAGTVTVVDALGGEYYAKQHLPGAVPLVAAD
                     VDAQAPALLPDRGAAIVTYCSNPACPNSGQVADRLTALGYTHVRKYREGIEDWVSAGLP
                     TESA"
     gene            3436..4053
                     /locus_tag="ACTIVE_RS35885"
                     /old_locus_tag="ACTIVE_7201"
     CDS             3436..4053
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017599884.1"
                     /locus_tag="ACTIVE_RS35885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7201"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_173099144.1"
                     /transl_table=11
                     /translation="MPRDDTGPQSASAMPLELLRTPPPKERSDAARNRAAVLEAAGRLF
                     AERGVEAVSMDQVAAEAGVGKGTLFRRFGDKAGLAAALLDARERVLQEAILHGPPPLGP
                     GAGEEERLAAFVGAYLDYLLEHLALVRMSETAAPGARYRIGAYRFWHRHVAILAAGAED
                     PEYTAHAVLAALSAEHVAALLPELGEERVREGGVRLARSVLR"
     gene            complement(4168..5571)
                     /gene="lpdA"
                     /locus_tag="ACTIVE_RS35890"
                     /old_locus_tag="ACTIVE_7202"
     CDS             complement(4168..5571)
                     /EC_number="1.8.1.4"
                     /GO_function="GO:0004148 - dihydrolipoyl dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /GO_process="GO:0051068 - dihydrolipoamide metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="lpdA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013156354.1"
                     /locus_tag="ACTIVE_RS35890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7202"
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="WP_173099145.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.8e-68, bitscore:
                     228.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEHFDVVVLGAGPGGYVAAIRSAQLGLKTAIIEERYWGGVCLNV
                     GCIPSKALLRNAELAHIFTQEQKTYGISVEGSVTFDYGVAYQRSRQVSDKLVKGVQFLM
                     KKNKITSYDGRGTFTDANTLQVAKADGSSETVTFDNCIIAAGAHTKLLPGTSLSERVVT
                     YEEQILSSELPGSIVIAGAGAIGVEFAYVLHNYGVKVTIVEFLDRMVPNEDADVSKELA
                     KRYRKLGIDVLTSTRVDGIDDSGDKVKVTVTGKDGAQQVIETDKVLQAIGFQPNVDGYG
                     LDKTGVRLTDRGAIDVDGRCRTSVPHIYAIGDVTAKLMLAHAAESMGIVAAETIAGAET
                     MELEYVMIPRATYCQPQVASFGWTEAQAKEQGFDVKVAKFPYSANGKALGMGEGDGFVK
                     VISDAKYGEILGAHMVGPEVTELLPELTLAQQWDLTVHEVARNVHAHPTLGEAVKEAVH
                     GLAGHMINL"
     misc_feature    5670..5683
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.85"
                     /tool="antismash"
     misc_feature    complement(5720..5731)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.02"
                     /tool="antismash"
     gene            6008..6586
                     /locus_tag="ACTIVE_RS35895"
                     /old_locus_tag="ACTIVE_7203"
     CDS             6008..6586
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS35895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7203"
                     /product="hypothetical protein"
                     /protein_id="WP_173099146.1"
                     /transl_table=11
                     /translation="MRIPKRVNAVLDWMEQHFGALAVVVALVIVALVATLAPALVGLPV
                     AGFVIGIAAGGFLVHVRLTRRIARARAEVDDLLRENGALRHRNTVLASGVISRGAQETQ
                     ALVAIPEDDEDLVEDDPTRTAALPELTDELLGGDPGDTLGDGTSPGLDAEPDAAPAEDG
                     TEAARTGAAKGGPAADEADEDTAGNARKG"
     gene            6673..8082
                     /locus_tag="ACTIVE_RS35900"
                     /old_locus_tag="ACTIVE_7204"
     CDS             6673..8082
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658246.1"
                     /locus_tag="ACTIVE_RS35900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7204"
                     /product="MFS transporter"
                     /protein_id="WP_216858078.1"
                     /transl_table=11
                     /translation="MNAESGPEPAESAGTETARGGDHAAKEDVDLGAVHKAVIASAMGN
                     CIEWFDFGVFSAGVMTSIIGTRFFPEGSAGSATLRSFALIAAAFLARPFGGMFFGPMGD
                     KLGRKRVLATTIILMSGSTFVIGILPGYHAIGIAAPLLLLAVRLVQGFSTGGEYGGAAT
                     MIAEYAPTNRRGYFGSFLEFGTLTGYIMGAGLVLLVNLAVGDTAMHDWGWRIPFLIALP
                     LGAVGLYVRTRIEDTPTFQRMEAAGKKARSPLKETLEHYWKIILMLIGIVFLLNVADYT
                     LLTFMPSYLVDFLHLGSVTSQLITIGVEAAMMAVILPTGHLSDRIGRKPVLTIAAVGFL
                     LLSWPAFALMQTNNWLGVGLGYAIIGALLVLMLAVIGATFPAMFPTKVRYGAFAIGYNI
                     STSIFGGTAAVLVGSLIDVTGSNYIPAYYIMIAAAVALVPILMIKETANVPIERVGMEN
                     APEPVGSGAER"
     misc_feature    complement(8321..8336)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.38"
                     /tool="antismash"
     gene            8568..10001
                     /locus_tag="ACTIVE_RS35905"
                     /old_locus_tag="ACTIVE_7206"
     CDS             8568..10001
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017595267.1"
                     /locus_tag="ACTIVE_RS35905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7206"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_173099147.1"
                     /transl_table=11
                     /translation="MADPRRIGGADVTEEQLSLSTSAARNLATTTKSVPQMQGITSRWL
                     LKLLPWVEAHGGAYRVNRRLTYTVGDGRVTFVTTGADVRVIPRELGELPPLRGYDDELA
                     LDALAGRFTQQEYEPGDVVVEEGRPVDRVVLVVHGKLSRVGAGEYGAEAVHGTLADGDF
                     FGEQALLGTEAGAEPATWDTTVKALTTVTVLSMSESDFQETLGQSASLREHLDAYRASP
                     ERASNAHGEAAIDLASGHEGEPVLPGTFVDYEGSPREYELSVAQTVLRVHTRVADLYNE
                     PMDQVEQQLRLTVEALRERQEHELVNNRDFGLLHNTDLTQRVHTRSGPPTPDDMDDLLG
                     LVWKDPAFFLAHPKAIAAFGRECSARGVYPDSVDVGGHKVPGWRGIPIFPCNKIPVSKT
                     RTSSILLMRTGEATQGVIGLHRTGLPDEYQPGLSVRYMGIDDKALINYLVSCYYSAAVL
                     VPDALGMLESVEIAHGGAA"
     gene            10001..12262
                     /locus_tag="ACTIVE_RS35910"
                     /old_locus_tag="ACTIVE_7207"
     CDS             10001..12262
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017595266.1"
                     /locus_tag="ACTIVE_RS35910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7207"
                     /product="hypothetical protein"
                     /protein_id="WP_216858079.1"
                     /sec_met_domain="T1TS (E-value: 1.1e-83, bitscore: 281.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPFELPEFYMPHPARLNPHAEAAREHSRRWAHAMGILGPDPTGP
                     EVWDEDEYDAHDYALLTAYTHPDAPGPVLDLVNDWYVWVFYFDDHFLERYKRPRDLAGA
                     KEYLARLPAFMPVKAGGPPPPEPANPVERGLADLWERTVPLMSREWRARFAESTRNLLQ
                     ESAWELANIDEARVPNPVDYVQMRRKVGGAPWSADLVEVAAGAEVPARVAGTRPLRVLK
                     DAFSDAVHLRNDIFSYQRETESEGEVNNGVLVMERFFGTDPQRAAEITNDLLTSRMQQF
                     EHTAVTELPALFEEHGLSPAERRDVLRYARGLQDWQSGGQQWHLRSSRYMNQGAVPRRG
                     LTGLPEIAGLLGLGTSAVRIRSLTRPPGPPPGGGGFRLPEFSLPYEPLLNPRIAGLRAH
                     TAEWARHMGMLDGAVPGTWTPEAFDAADYALFAALTHPGAPGPELELIADWHLWRFFFD
                     DLFAERFKVPRDLLGARAYTARLLDPPSGHEPSDPVERGLADLRARTAAAMTEDERAGL
                     DAALRQLTDSWLWELAGLVHNRVPDPVDYIEMRRRTSGAAFTAALLRHAHAGGLPPDVL
                     AATPMQALHDTFADIAGLRNDLLSYPKEIGPEGEHHNAVVAVERFLGCGTQQAADIVAD
                     LVEARVRQFERTAESELPILAAESGLDAAARDGLARYVRAMRDWTAGDLRWSTTTGRYA
                     PPGGGTGPAPPPAPDTGFRVPSGPSGLGAAAARPPFRPVRPAPDRHNEAQPAIPGGSGT
                     "
     gene            12259..13629
                     /locus_tag="ACTIVE_RS35915"
                     /old_locus_tag="ACTIVE_7208"
     CDS             12259..13629
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630109.1"
                     /locus_tag="ACTIVE_RS35915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7208"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_173099148.1"
                     /transl_table=11
                     /translation="MTDPQLALSTRAARNLATTTKSVPQMQGITPRWLLTLLPWVRADA
                     GSYRVNRRLTYELGDGRVTFVNDGAAVRVIPGELAELPQLSGLDPMVLDAVAGRFAQTE
                     YAPGDTIAAAGDPLDRVHLIAHGKVAETGTGEYGGETQIAIRDGGDFFGDEALLGDAGT
                     WPHTFRALTPTIVLTLSPAAIVEVTERSETLRARLEEYRNAPKPPQTRHGEAAIDLASG
                     HEGEPALPGTFVDYETSPREYEMSVTQTLLRIHTRVADLYNEPMDQVEQQLRLTIEEIR
                     ERQEHELVNNRDFGLLHNADLRHRIQTRGGPPTPDDMDELLARRRKTRFYLAHPRAIAA
                     FGRECTRRGVYPGTAEIEGGRRIQAWRGVPIYPCDKIPVTPTGTTSIIAMRTGEDDQGV
                     IGLRRTGIPDEVQPGLSVRFTGIDDRAIMSYLVSAYYSAAVLVPDALGVLENVEIGR"
     gene            13644..14672
                     /locus_tag="ACTIVE_RS35920"
                     /old_locus_tag="ACTIVE_7209"
     CDS             13644..14672
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073756.1"
                     /locus_tag="ACTIVE_RS35920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7209"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_173099149.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8.8e-63, bitscore:
                     211.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVETSARSAAEILAWSRGLVEPALRSVVGAMPPAMRGIAEFHFG
                     WRDEAGRAAAGAGGKSVRPALTLLAAEASGGTAAAAVPAAVAVELTHNFSLLHDDVMDG
                     DRTRRHRPTAWTVFGVSAAILAGDALLAGAYEALAEAPSPDPAGAVRVLSRAVLELVEG
                     QSADTAFEDRTDVTLAECLAMAGGKTGALLGGACALGALYGGGAGRAGRYRAFGERLGL
                     AFQLVDDLLGIWGDPEVTGKPVHSDLRNRKKSLPVVAALTSGTPAGEELAALYLRRGAL
                     AGDEPARAAALIEAAGGRAWAAAEADALVAGALTELDAADPVPAAAGELRSVAHMLTHR
                     DH"
     gene            14771..16240
                     /locus_tag="ACTIVE_RS46940"
                     /old_locus_tag="ACTIVE_7210"
     CDS             14771..16240
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851499.1"
                     /locus_tag="ACTIVE_RS46940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7210"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_216858080.1"
                     /sec_met_domain="Pkinase (E-value: 1.1e-40, bitscore:
                     138.8, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDLHPLEPTDPQRLGGYRVTGRIGEGGQGVVYAAVPDGGGDRVA
                     VKLFHAQLTGDPGALDTFARELEAAKQVARFCTAQVLDSGAFGNRRFIVSEYIDGPPLS
                     SVVRDGGPRSGSALDRLAIATATALVALHDAGVVHRDVKPHNVLIGADGPRVIDFGISR
                     ALSGAQTVVSRAVGTPAYMAPEQLQPGELGPAVDVFAWASTMVFAATGRPPFGNESIPV
                     VMNRIAHEPPRLDGVEEPLRGLLAECLAKDPARRPTAQNVLDRLVRRSQQTSPGGVPAP
                     GPAPEPAVEAAADVSTLPRDRRRNRRRAGVLAGAGAAVVAGAAVFGIVQMADGDTGGGG
                     PHATPQGTAGTAAGQGGTAEAGHAAVPGSGSPSASASAGRSPAAGPSTAASRPATSGKP
                     SGGPSASPSYQRVELGPGHFSAYCAKLGWEWEEYRTAPAPGAYCVAHKRAAQLMSKAQL
                     DAGCRWRYDDPRARHYFKGQSNYCYTLKQVS"
     gene            complement(16237..16659)
                     /locus_tag="ACTIVE_RS35930"
                     /old_locus_tag="ACTIVE_7211"
     CDS             complement(16237..16659)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017569030.1"
                     /locus_tag="ACTIVE_RS35930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7211"
                     /product="DUF6069 family protein"
                     /protein_id="WP_173099150.1"
                     /transl_table=11
                     /translation="MNEMTETRPATGGTAVRRSLTVAAAAAAALAIWVVAGPVLGAGMH
                     AGGRHVGPVMVVVSSLVAGLAGWGLLAVMERRAKRPARTWAITAAVVLGVSLTGPRSAH
                     GGTFAALTAMHLVVGVIVIAGLAATARGRGRARRQG"
     gene            16791..17948
                     /locus_tag="ACTIVE_RS35935"
                     /old_locus_tag="ACTIVE_7212"
     CDS             16791..17948
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890862.1"
                     /locus_tag="ACTIVE_RS35935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7212"
                     /product="histidine kinase"
                     /protein_id="WP_216858081.1"
                     /transl_table=11
                     /translation="MNSENACEVEQRDPRLAAGSAVVVATVGALGALTVWGRSGGPPGA
                     LAVDIAAGVLACVLAPVVLWRPVAGTLALTVLAALSPAATPAATFGALHVAQRRRFPVA
                     LAVGAAGVAGHAVQGLWRPEGGITYGWWLLVVALAYGALVGWGALAQARRALLASLRER
                     ARRAEAEQGRRVAEARMLERTRMAREMHDVLAHRLSLLATYAGALEYRPDAPPEKLAQA
                     AGVVRAGVHQALDELREVISVLRDEDARDDDRPQPVLADLPALVAESRDAGGSVQLRDE
                     VVEPAALPAAAGRTAYRVVQEGLTNARKHAAGRPVRVAVEGRPGTRLVIDIRNPLPPDG
                     AVPLAPGTGTGLVGLTERVQLAGGRLDHEIAAGEFRLRAWLPWPA"
     gene            17936..18598
                     /locus_tag="ACTIVE_RS35940"
                     /old_locus_tag="ACTIVE_7213"
     CDS             17936..18598
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153057.1"
                     /locus_tag="ACTIVE_RS35940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7213"
                     /product="response regulator transcription factor"
                     /protein_id="WP_173099151.1"
                     /transl_table=11
                     /translation="MARVNRPLRVLIVDDDALVRAGLSMMLDGVHGISVAGEAADGAEV
                     PEAADLHAPDVVLMDLRMPRVDGITATRALRGRDPAPEVIVLTTFDTDENILHALRAGA
                     SGFLLKDTPPAQIVEAVRRVAAGEPILSPRITRRLMDRAATQAGAYERARAALGRLSPR
                     ENDVVAAIAAGRSNAEIGAALFMSVATVKAHVSSILTKLDLDNRTQIALLAHDAGLA"
     gene            complement(18606..19037)
                     /locus_tag="ACTIVE_RS35945"
                     /old_locus_tag="ACTIVE_7214"
     CDS             complement(18606..19037)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024559.4"
                     /locus_tag="ACTIVE_RS35945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7214"
                     /product="DUF3995 domain-containing protein"
                     /protein_id="WP_173099152.1"
                     /transl_table=11
                     /translation="MSILELAALLAAAVLGLDALLHVYWMTGRTWPARDVTTLSQGLLN
                     ADVPFTPRVLAPLVAVLTAGAIAVPARAGLILSGVPGWIPAAGTVAVAAGVALRAGAGV
                     VWALGVGARRDSAFYKLNLALYTPLCLVLTAATLRVAVA"
     misc_feature    complement(19026..19041)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.26"
                     /tool="antismash"
     misc_feature    complement(19073..19088)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            complement(19084..19542)
                     /locus_tag="ACTIVE_RS35950"
                     /old_locus_tag="ACTIVE_7215"
     CDS             complement(19084..19542)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS35950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7215"
                     /product="hypothetical protein"
                     /protein_id="WP_173099153.1"
                     /transl_table=11
                     /translation="MTWPLGELDDVRRLRALAAAFPGVLLEEAVLPAAFEDVWAVLGDP
                     EGGFPGLVPDVRSLRVTERESERMRALVRGRSGLRARFDMVLRPGWCLMQSRFLVFGMA
                     AVRDGDATRFAYMAGLRVPGVRFAGPVLRRVLGPVVLRRFVRRFTPAE"
     gene            complement(19539..20051)
                     /locus_tag="ACTIVE_RS35955"
                     /old_locus_tag="ACTIVE_7216"
     CDS             complement(19539..20051)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="ACTIVE_RS35955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7216"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_216858082.1"
                     /transl_table=11
                     /translation="MSAPDPDVVRRAQRGDLMALDEVLDALAPYVRRLCGPIALQDAPD
                     AAQETLIAVMRGLKTLRDPAALLGWVRVIAVREAVRAARQSARSVPAEPADLPAPGDPS
                     LAADVRDVLDRLPPEQRAVLVLRDLEGLDEATAARMLRVPEGTVRSRLFRARARFRLNW
                     RDEGSPP"
     misc_feature    20077..20092
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 23.31"
                     /tool="antismash"
     misc_feature    complement(20078..20091)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.96"
                     /tool="antismash"
     gene            20096..20317
                     /locus_tag="ACTIVE_RS35960"
                     /old_locus_tag="ACTIVE_7217"
     CDS             20096..20317
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS35960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7217"
                     /product="hypothetical protein"
                     /protein_id="WP_173099154.1"
                     /transl_table=11
                     /translation="MHVPFLCPRGHRLVPGRVIVGWSPCVCPPCGGRARGLRGHRTYLC
                     LDCKDEHVTTKCYLPYHVPAQGTAYRWP"
     gene            20341..21195
                     /locus_tag="ACTIVE_RS35965"
                     /old_locus_tag="ACTIVE_7218"
     CDS             20341..21195
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634238.1"
                     /locus_tag="ACTIVE_RS35965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7218"
                     /product="oxidoreductase"
                     /protein_id="WP_173099155.1"
                     /transl_table=11
                     /translation="MTGRWALGGDLDVARIGYGAMRLSGWPGGPRPDRYTALAVLHRAV
                     ELGVNHLDTSNYYSHDGVSANELIREALHPYPDDLVIVTKVGALVEGSDVHLPAGEHTG
                     LTPSGLRRAVEANLRTLGLDRLDVVNLRMGLFGTSEESLAEPLETMAALRDEGLIRHLG
                     VSNVTPAQVAEARGIAPIACVQNEYNVSRRDDDPLVDACAGAGIAYVPFSPVGGFQPLT
                     ADHLDTVAARHGATVPQVALAWLLARSPNILLIPGTGSPAHLEENLAAAGLRLTPEDLA
                     DLA"
     misc_feature    21231..21246
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     gene            21304..21906
                     /locus_tag="ACTIVE_RS35970"
                     /old_locus_tag="ACTIVE_7219"
     CDS             21304..21906
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012886889.1"
                     /locus_tag="ACTIVE_RS35970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7219"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_173099156.1"
                     /transl_table=11
                     /translation="MIGIRARPGPAAGTARGDAEPIRRSLAEPEAFTALYDRHAPAIHR
                     YVARRLGPDAADDLMAETFLIAFRKRSRYDLARADARPWLYGIATRLVARHRKAETSRY
                     LLLERLGGETAADPVDSEARVSAQALRGPLARALAGLPAIYREPLLLVAWADLSYEEVA
                     AALEIPVGTVRSRLSRGRARLRAALGGADPTEEDIDG"
     gene            21899..22837
                     /locus_tag="ACTIVE_RS35975"
                     /old_locus_tag="ACTIVE_7220"
     CDS             21899..22837
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038083.1"
                     /locus_tag="ACTIVE_RS35975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7220"
                     /product="CU044_5270 family protein"
                     /protein_id="WP_173099157.1"
                     /transl_table=11
                     /translation="MDEMALLREAGADVAPPTDAALQAGRDRLAAAARPARRRPPRLRR
                     PAALGLLAAAAAVAGAAAITMAQVVAPDGHGSATAAAAEVLRDAAATARGGPPVRPSAY
                     SYTRELLVFPGEPGRQCEETWLRRDGSLAAGGTFPERRGGHCDPHEPGRWLPSLRDGDA
                     DRRPHADVRTLPTVPSALRARLYSDAAHGRGQNADDKGPRDQLVFNRIGRLLRMPLPPE
                     LRAALFQTLATVPGVDVVRGERDALGRQGIALARSFGDPGDTTRVEIILAPGTYRYLGM
                     KAVQDMGAPAPLTRLSALLTTAAVTTPYQRP"
     gene            complement(22880..23473)
                     /locus_tag="ACTIVE_RS35980"
                     /old_locus_tag="ACTIVE_7221"
     CDS             complement(22880..23473)
                     /EC_number="1.-.-.-"
                     /EC_number="1.4.3.5"
                     /GO_function="GO:0004733 - pyridoxamine phosphate oxidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017602727.1"
                     /locus_tag="ACTIVE_RS35980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7221"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_173099158.1"
                     /transl_table=11
                     /translation="MGKSYERIEGRLRAFIEAQHIFFTATAPLDGDGTVNLSPKGLTGS
                     FAVLDELTLAYLDFAGSNAETIAHLRENGRITLMWCAFEGPPNIVRVHGRGEPVFRDDP
                     RWDGLMRHFPDIDVTVHGLRAIIVVKAEKIRDTCGYAVPFMTYGEDRPLHASRFAREDD
                     ASLDAYFHKKEHVATSIDGLPGLPLPLPPLPPTA"
     misc_feature    23750..23764
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.87"
                     /tool="antismash"
     misc_feature    24054..24068
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.45"
                     /tool="antismash"
ORIGIN
        1 aggcgctcga aggagccaaa cttctcgaca aggacctgcc gccggtcacc aggcggagcg
       61 tcatcatcag gaaggccacc tacgacgtcg aagccaaccg gtaccggcag ttgagccagg
      121 acaacaagat cttgacggct ctggagcacg tgcccggcgg gaaatggctg ctcgacggtg
      181 accggattcc gcggagcctc accgaggtcc cgggcctggg gaaggtcggg ctggcgagca
      241 agggcatccc ggtcgccggc tggatcgtca cagggctcgc catcgggaat gacatccgcc
      301 agggaaagaa gccggcgaag tcggccgcgg ccgagatcgg cggcaccgtg gccggttccg
      361 ccgtcaccgg cgcggtggac ggggcgatca cggggcccga gggggccgtg atcggcgggc
      421 ccgccggcgt catcgtcggg gcgggcgtgt ccttcggcat cgacaagtgg ggcgggacgg
      481 tcgcctccaa gttcgccgaa tcgggaagcg gactgctcca tggtgccgcc gacggcgcca
      541 aggagctctc ttggccgagg ttccggtgaa aggaccgacg agggggagac tgcctccgag
      601 gccggatgag ctgaccggga tgccgaggcc gccggaggct ccggacttcc gcgaatggga
      661 cgggccattg aaggccccga ggaggcggcg tccgcggccg cctcgcgggc agggcgtcac
      721 cttggaatgg acgccgcggc agcgggacca caaggccctt ggggcgttcc tcactctctg
      781 cgtcatcgga gcgatctacc tcgcgatcgc gaaccggggc ttcgcctggg tgctggactg
      841 gcgcatgtcg gctctgctgt tcgcgctctc gggcctgggg gcgcttttcg gcctcatcga
      901 atggcggatc gactgcgggg ccgactggct tcgccacgcc tggaggtggg tgaagctgta
      961 cgagctgacc gagatcgagg tcgtcaaggc gcaggaactg cggctcaagg acagggggga
     1021 gcgggaggtc aagatcgagc tgaaggagtt cggcaagaat caggagctct gggatctcgt
     1081 ctacaacggg atccagcact cgtatcacta cggcggggcg acggcggatt ccgggactcg
     1141 gttgtcgctg agtctctaca agccggttct ggtgccgctc accggattcg aggacgagag
     1201 cgagatcgtc gagcacgacg tggacgcggc cgtccgggac ttcctcgcgt gggagccgga
     1261 ctcgccggag gaccgggccc ggatgcgcaa gcgggaggcc gagctgcgcg aggcgtggtg
     1321 gcccggcggc ggggacgagg agccgccgcc gggcgggtga gtcaggcgcg cagttccagc
     1381 gtgcagcact tcgggccgcc gccggccttg cggagctcgg acaggtccac cgggacgggc
     1441 tcgtacccgt gctcgcgcag cgtgccgatc aggcccgcgg cctcggcgtt gatgacgacg
     1501 ttgcggccgt cgcagacggc gttgaggccg aggacggccg cgtccgcctc gccggcgatg
     1561 agggcgtccg ggaagagccg ttcgaggacc gcgcggctgc cgggggagaa ggcgcccggg
     1621 tagtaggcga cgttcgagcc gccgagcggg aacagcgcgg tgtccaggtg gtagaagcgc
     1681 gggtcgacca gccgcagggt caccacgggg cggccgagga actcctgcgc ctcctggtgg
     1741 gcggcgatgt cggtgcggaa gcccgtcccg gcgaggatga cgtggtcgag ggtgaggaag
     1801 tcgccctcgc cctcgttggt gtgctcgggc ggcaggacgt ccgggaagcc gttcttgcgg
     1861 agccagtcgg cgtaggcggg gccttcggcc gcccgctcgg ggaaggtgaa cttcgcgccg
     1921 taggcgcgcc cgccgacgac gagggcgccg ttcgcggcga acaccatgtc cggaaggccc
     1981 tcgatcgggt cgatgaggct gacctcgtgc ccgagcgcgg cgtaggcggc gcgcagcgcc
     2041 tcccactgct cgacggcccg ccccgcgtcc gcgccggcgg ccgggtccat ccacgggttg
     2101 atggcgtagg tcacggcgaa gtggtcgggt cggcacatca ggtagtgccg ccgcagcgcg
     2161 gtgcgccgcg gggtgctcgg ctccgtcgcc ggcatcacgg tcatgctcgt ctcctgggct
     2221 tccaaaggga ctcgactgag cgaaagccta gaaacgaaac cgccgcattc caatgcgtcg
     2281 gccttgcgct gacctgcgga ttcgttgcgt gttcgacggg ctgggcggcg attcgttgcg
     2341 gcccgggaag cgggttgacg ggccgtcagg gcagcggcgt gaacatgtgg tcgagcatgg
     2401 tgtgcaggaa ggtgcggaag cccgcgatgt cgtcgtgcgg gcagggcgcg ctgctcggcg
     2461 tgtggcgctg gggcgcctcg tccgggccgc tgcggaccag gccgccggtg aggaagccgt
     2521 agacgcacca gacgacggac cagatcaggt agtccgggtc gacgtcgggc gggacgaggt
     2581 cgcgcaccgt gtcggcgatg tcgcgcgaca gcggcctggt gtagatctcc tcgaggtcgg
     2641 gcaggtcggc ggcgtcgccc atccaccggt gctgccagag cgccagcacc tgcgggtggg
     2701 agacgtagaa gtccaggtag gcgtccgcga gcatgatgac gccgccccgg tccgccgtga
     2761 acccggcgag cgcctcgcgc agcgccgcct cctcgctctc gtcggcgttg cgcatcacgg
     2821 cgcggtacag gtccgccttg gtcgcggcga tgccgtggac ggcgccgatg tcgtagcccg
     2881 ccgcgtcggc gatcatctgc agcgacgtcc cgtcgtaccc gagttcggcg aagatccgcg
     2941 tcgcggtctc gatcagccgg tcctcttcgg ttccccccat gtgctcactc taagtgacgc
     3001 cttcgggacg gttccggggg tgccgccgtg cgggccgggc gccgggcgcg cccggcccgc
     3061 tccggcgggt caggcggact cggtgggcag cccggcggac acccagtcct cgatgccctc
     3121 gcggtacttg cggacgtggg tgtagccgag cgcggtgagc cggtcggcga cctggccgct
     3181 gttggggcag gccgggttgg agcagtaggt gacgatcgcg gcgccgcggt cgggcagcag
     3241 ggcgggcgcc tgcgcgtcga cgtccgccgc gacgagcggc acggctcccg gcaggtgctg
     3301 cttggcgtag tactcgccgc cgagcgcgtc gacgacggtg acggtgccgg cgtcgatcgc
     3361 ggccttgagc tcgtcccggc cgatccgtgc ggtcatggca gtgcctccag agatgagacg
     3421 gactatagtc cggttatgcc tcgagacgat accggaccgc agtccgcttc tgcaatgccg
     3481 ctggaactgc tccgcacccc gccgcccaag gagcgctcgg acgcggcccg caaccgggcc
     3541 gccgtgctgg aggcggccgg gcggctgttc gccgagcggg gcgtcgaggc ggtgtcgatg
     3601 gaccaggtgg cggcggaggc cggcgtcggc aaggggacgc tgttccggcg gttcggcgac
     3661 aaggcggggc tggccgcggc cctcctggac gcgcgggagc gcgtgctgca ggaggcgatc
     3721 ctgcacgggc cgccgccgct cggcccgggg gcgggggagg aggagcgcct ggccgcgttc
     3781 gtcggggcgt atctcgacta cctgctggag cacctggcgc tcgtgcggat gtcggagacc
     3841 gcggcgccgg gcgcgcggta ccggatcggc gcgtaccggt tctggcaccg ccacgtcgcg
     3901 atcctggcgg cgggcgcgga ggaccccgag tacaccgcgc atgccgtgct cgcggcgctg
     3961 tccgccgagc acgtggcggc gctcctgccg gaactgggcg aggagcgcgt cagggaaggg
     4021 ggcgtccggc tcgcccggtc cgtcctgcgg tgaccgggcg gcgggacacg gggaggtggg
     4081 ccccggggag gcgggctccc ggggagccgg ggaggtggga cgcgacgcgg cgtgcccgtc
     4141 cggggcgggc gggcacgccg gatcggatca gaggttgatc atgtggccgg cgaggccgtg
     4201 cacggcctcc ttgacggcct cgcccagggt cgggtgggcg tgcacgttgc gggcgacctc
     4261 gtggacggtg aggtcccact gctgcgcgag ggtcagctcg ggcagcagct cggtcacctc
     4321 ggggccgacc atgtgggcgc cgaggatctc gccgtacttg gcgtcgctga tcaccttgac
     4381 gaagccgtcg ccctcgccca tgccgagcgc cttgccgttg gcgctgtagg ggaacttggc
     4441 gaccttgacg tcgaagccct gctccttcgc ctgcgcctcc gtccagccga acgaggcgac
     4501 ctgcggctgg cagtaggtcg cgcgggggat catcacgtac tcgagctcca tggtctcggc
     4561 gcccgcgatg gtctcggcgg cgacgatgcc catggactcg gcggcgtgcg cgagcatcag
     4621 cttggcggtg acgtcgccga tcgcgtagat gtgcgggacg gacgtgcggc agcggccgtc
     4681 cacgtcgatc gcgccgcggt cggtgagccg cacgccggtc ttgtcgaggc cgtagccgtc
     4741 cacgttcggc tggaagccga tcgcctgcag caccttgtcg gtctcgatga cctgctgcgc
     4801 gccgtccttg ccggtgacgg tcaccttgac cttgtcgccg gagtcgtcga tgccgtcgac
     4861 ccgggtggag gtcagcacgt cgatgccgag cttgcggtac cgcttggcca gctccttgga
     4921 cacgtccgcg tcctcgttcg ggaccatccg gtcgaggaac tcgacgatcg tgaccttgac
     4981 gccgtagttg tgcaggacgt aggcgaactc gacgccgatg gcgcccgcgc cggcgatgac
     5041 gatgctcccc ggcagctcgg agctgaggat ctgctcctcg taggtgacga cccgctccga
     5101 cagcgacgtg ccgggcagca gcttggtgtg cgcgcccgcc gcgatgatgc agttgtcgaa
     5161 ggtgacggtc tcggacgagc cgtcggcctt ggccacctgc agggtgttgg cgtcggtgaa
     5221 cgtcccgcgc ccgtcatagg aggtgatctt gttcttcttc atcaggaact ggacgccctt
     5281 gacgagcttg tccgatacct ggcggctgcg ctggtaggcg acgccgtagt cgaaggtgac
     5341 gctgccctcg acgctgatcc cgtaggtctt ctgctcctgg gtgaagatgt gcgccagctc
     5401 ggcgttgcgt agcagcgcct tcgaggggat gcagccgacg ttgaggcaca cgccgcccca
     5461 gtaccgctcc tcgatgatcg ccgtcttcag cccgagctgt gccgaccgga tcgcggcgac
     5521 atatccaccc gggcccgcgc ccaggaccac gacgtcaaag tgttcgctca tatccactga
     5581 cgatattcgg cgcggggccg tgctcgcatc ccggacggcg cggcgcggcg gccccggcgg
     5641 gccgtgcggc gcgccgtacg gaccggccgg ccacgccgcg tgaccgcggg gctccggtac
     5701 ggctccgtcg tcacatgctg ttaaggtttt cggagtcccc cgcccgctga actttcgcgg
     5761 gggcgggcgg cgcccgggcg gcgcgacggc accgtcgccg gtggcgcgca cccgtgacct
     5821 ccggccgcga gcccggcggc gttcccggaa cggcccgcgg gcggcgccga ctcccgggcc
     5881 gctccccggc cgcgccgccg cccggacacg gcggcgccgg aacaccgcgg tgcccgccga
     5941 tcgttgccct cgaacgcccc tgccccgggc gcagcggccg tcccgagccg agtggaggag
     6001 aagccgagtg aggattccca agcgcgtcaa cgccgtcctg gactggatgg agcagcactt
     6061 tggcgcactt gcggtggtcg tcgcgctggt gatcgtggcg ctggtcgcca cgctcgcgcc
     6121 ggcgctggtc gggcttcccg tcgccggctt cgtgatcggg atcgccgcgg gcggcttcct
     6181 cgtgcacgtc cggctgaccc ggcggatcgc gcgggcccgc gcggaggtcg acgacctgct
     6241 ccgcgagaac ggcgcgctgc ggcaccgcaa caccgtcctc gccagcggcg tgatcagccg
     6301 cggcgcgcag gagacgcagg cgctggtggc catcccggag gacgacgagg acctcgtgga
     6361 ggacgacccg acccgcaccg cggcgctccc ggagctgacc gacgagctgc tcggcggcga
     6421 cccgggtgac accctcggcg acggcacgtc cccgggcctc gacgccgagc ccgacgccgc
     6481 accggcggag gacgggaccg aggccgcgag gaccggcgcc gcgaagggcg ggcccgcggc
     6541 cgacgaggcc gacgaggaca ccgccgggaa cgcccggaag ggctgaccgg gcgaccgcac
     6601 cgagacatcg cgccgcaaaa ccgggcgtta actccgccga tcttcgggca gagggaaggc
     6661 cgggaggtgc ggatgaacgc agagtccggt cccgagcccg cggaatcggc ggggacggag
     6721 acggcgcggg gaggcgacca cgccgcgaag gaggacgtgg acctcggggc ggtgcacaag
     6781 gccgtcatcg cgtccgcgat gggcaactgc atcgagtggt tcgacttcgg cgtgttcagc
     6841 gccggggtga tgacctcgat catcggcacg aggttcttcc ccgagggcag cgccggcagc
     6901 gccacgctgc gctcgttcgc gctgatcgcc gcggcgttcc tcgcccgccc gttcggcggg
     6961 atgttcttcg gcccgatggg cgacaagctc ggccgcaagc gggtgctcgc caccacgatc
     7021 atcctgatgt cgggctccac gttcgtgatc ggcatcctgc ccggctacca cgcgatcggg
     7081 atcgcggcgc cgctgctgct gctggcggtg cggctcgtcc aggggttctc cacgggcggc
     7141 gagtacggcg gcgccgccac gatgatcgcc gagtacgcgc cgacgaaccg gcgcggctac
     7201 ttcggcagct tcctggagtt cggcacgctg accggctaca tcatgggcgc cgggctcgtg
     7261 ctgctggtga acctcgcggt cggggacacc gcgatgcacg actggggctg gcggatcccg
     7321 ttcctgatcg cgctgccgct cggcgccgtc gggctgtacg tgcggacccg gatcgaggac
     7381 accccgacgt tccagcggat ggaggcggcc ggcaagaagg cgcggtcgcc gctgaaggag
     7441 acgctggagc actactggaa gatcatcctg atgctgatcg ggatcgtctt cctgctgaac
     7501 gtcgcggact acacgctgct caccttcatg ccgtcctacc tggtcgactt cctgcatctc
     7561 ggcagcgtga cgtcgcagct gatcaccatc ggggtggagg ccgcgatgat ggcggtgatc
     7621 ctgccgaccg ggcacctgtc cgaccggatc ggccgcaagc ccgtgctgac catcgcggcg
     7681 gtcgggttcc tgctgctgag ctggcccgcg ttcgcgctga tgcagaccaa caactggctc
     7741 ggcgtcgggc tcggctacgc gatcatcggc gcgctgctgg tgctgatgct cgcggtgatc
     7801 ggcgcgacgt tccccgcgat gttcccgacg aaggtgcggt acggggcgtt cgcgatcggc
     7861 tacaacatct cgacgtcgat cttcggcggg acggcggcgg tgctggtcgg gtcgctcatc
     7921 gacgtgacgg gcagcaatta catcccggcg tactacatca tgatcgcggc ggcggtggcg
     7981 ctggtcccga tcctgatgat caaggagacg gcgaacgtgc cgatcgagcg ggtcgggatg
     8041 gagaacgccc cggaaccggt gggctccggg gcggaacgct gacccccgcg ccgtaggggc
     8101 gggggcggcg gcgtcagcgg gcgaagtgcc ggcgggccca gcccgccagc gaacccgcga
     8161 tcacgagcgc ggcggtcgtc tcgagcgcca gtgcggtcca cacggtggtc accgggggcc
     8221 tccctccgtc tccggcggga cgcgtccgtc ccgcgtccga tatgcacctg gagtaacacc
     8281 agaatgcggt cacggtttcc ctgcccgagc cgccgcagag cgtgattccg gtcacgtccc
     8341 accgcgctga cctgggatga aacctccatg gacggtaaaa accctggtcg tcgccgcgcc
     8401 agcgggcccc gggccgcggg agagaggcgg cggcccgccc gtcacgggcg cgcggcggtt
     8461 ccgggccggg ctatcgcccg gcggtgtgac ttgtgtggcc ggaaggcgaa catatagctc
     8521 gttgcgcccg ttcgattacc gtgggtagcg tctccgttgg ttcatccatg gcagacccac
     8581 gacgaatcgg tggtgcggac gtgacggaag agcagttgag cctcagtaca tctgcggcac
     8641 ggaacctggc gaccacgacc aagtccgtcc cccagatgca ggggatcacc tcccggtggc
     8701 ttctgaagct gctgccgtgg gtggaggcgc acggcggcgc ctaccgcgtc aaccggcggc
     8761 tcacctacac ggtcggcgac gggcgggtga cgttcgtgac gaccggcgcc gacgtgcggg
     8821 tcatcccgcg cgagctcggc gagctccccc cgctgcgcgg ctacgacgac gagctcgcgc
     8881 tggacgccct cgcgggccgg ttcacccagc aggagtacga gcccggcgac gtcgtcgtcg
     8941 aggagggccg gccggtcgac cgggtcgtgc tggtcgtgca cggcaagctc agccgggtcg
     9001 gggcgggcga gtacggcgcg gaggccgtgc acggcaccct cgccgacggc gacttcttcg
     9061 gcgagcaggc cctgctcggc accgaggcgg gtgcggagcc cgcgacctgg gacaccaccg
     9121 tcaaggcgct gaccaccgtc acggtgctca gcatgagcga gagcgacttc caggagacgc
     9181 tcggccagtc cgcctcgctg cgcgagcacc tggacgccta ccgggcgagc ccggagcggg
     9241 cgagcaacgc gcacggcgag gccgcgatcg acctggcgtc cgggcacgag ggcgagccgg
     9301 tgctgcccgg cacgttcgtc gactacgagg gctccccgcg cgagtacgag ctgagcgtcg
     9361 cgcagacggt gctgcgcgtc cacacccgcg tcgccgacct ctacaacgag ccgatggacc
     9421 aggtggagca gcagctccgg ctgaccgtcg aggcgctgcg cgagcggcag gagcacgagc
     9481 tggtcaacaa ccgggacttc gggctgctgc acaacaccga cctgacgcag cgcgtccaca
     9541 cccggtccgg ccccccgacc cccgacgaca tggacgacct gctcggcctc gtctggaagg
     9601 acccggcgtt cttcctcgcc cacccgaagg cgatcgcggc gttcggccgc gagtgcagcg
     9661 cccgcggcgt ctaccccgac agcgtcgacg tcggcggcca caaggtgccg ggctggcgcg
     9721 gcatcccgat cttcccctgc aacaagatcc cggtcagcaa gacccgcacc agctcgatcc
     9781 tgctgatgcg caccggcgag gcgacgcagg gcgtcatcgg cctgcaccgg accgggctgc
     9841 cggacgagta ccagccgggc ctgtccgtcc ggtacatggg catcgacgac aaggcgctca
     9901 tcaactacct ggtcagctgc tactactcgg cggccgtcct ggtccccgac gcgctcggca
     9961 tgctggagtc cgtcgagatc gcgcacggtg gtgcggcgta gtgcagccgt tcgaactccc
    10021 cgagttctac atgccgcacc ccgcgcggct gaacccccat gccgaggcgg cccgcgagca
    10081 ctcccgccgc tgggcgcacg ccatggggat cctcggcccc gatccgacgg ggcccgaggt
    10141 ctgggacgag gacgagtacg acgcgcacga ctacgcgctg ctcaccgcgt acacgcaccc
    10201 ggacgcgccc ggtcccgtcc tggacctggt gaacgactgg tacgtgtggg tgttctactt
    10261 cgacgaccac ttcctcgagc ggtacaagcg gccccgcgac ctcgcgggcg ccaaggagta
    10321 cctcgcgcgg ctccccgcct tcatgccggt gaaggcgggg ggtccgccgc cccccgagcc
    10381 ggcgaacccg gtcgagcggg gcctcgccga cctgtgggag cggaccgtcc cgctcatgtc
    10441 gcgggagtgg cgggcccggt tcgccgagag cacccgcaac ctgctgcagg agtcggcgtg
    10501 ggagctggcg aacatcgacg aggcgcgcgt cccgaacccg gtcgactacg tgcagatgcg
    10561 ccgcaaggtg ggcggcgcgc cctggtcggc ggacctcgtc gaggtcgcgg cgggcgcgga
    10621 ggtgccggcg cgggtcgcgg ggacgcgccc gctgcgggtg ctgaaggacg cgttctccga
    10681 cgccgtccac ctgcgcaacg acatcttctc ctaccagcgg gagaccgaga gcgaaggcga
    10741 ggtcaacaac ggcgtcctgg tgatggagcg gttcttcggg accgatccgc agcgcgccgc
    10801 ggagatcacc aacgacctgc tgacgtcgcg gatgcagcag ttcgagcaca ccgccgtcac
    10861 cgagctgccc gccctgttcg aggagcacgg gctgagcccg gcggagcgcc gcgacgtgct
    10921 gcgctacgcg cgcggcctgc aggactggca gtccggcggg cagcagtggc acctgcggtc
    10981 cagccgctac atgaaccagg gcgcggtgcc gcggcgcggg ctgacgggcc tgccggagat
    11041 cgccgggctg ctcgggctcg gcacgtccgc ggtgcggatc cggtcgctga cccgcccgcc
    11101 ggggccgccg cccggcggcg gggggttccg gctgcccgag ttctcccttc cgtacgagcc
    11161 gctgctcaac ccccggatcg ccgggctccg cgcgcacacc gcggagtggg cccggcacat
    11221 gggcatgctg gacggcgccg tccccggcac gtggacgccg gaggcgttcg acgccgccga
    11281 ctacgccctg ttcgccgcgc tcacccatcc cggcgcgccc ggtcccgagc tcgagctgat
    11341 cgccgactgg cacctgtgga ggttcttctt cgacgacctc ttcgccgagc ggttcaaggt
    11401 tccccgcgac ctgctcggcg cccgggcgta cacggcccgg ctgctcgatc cgccgagcgg
    11461 gcacgagccg tccgacccgg tggagcgggg gctcgccgac ctgcgggccc gcaccgccgc
    11521 cgccatgacc gaggacgagc gcgccgggct cgacgcggcg ctgcggcagc tcaccgacag
    11581 ctggctgtgg gagctggcgg gactcgtcca caaccgcgtc cccgaccccg tcgactacat
    11641 cgagatgcgc cgccggacga gcggcgccgc gttcaccgcc gcgctgctgc gccatgccca
    11701 cgcgggcggg ctgcccccgg acgtcctcgc ggccacgccg atgcaggcgc tgcacgacac
    11761 gttcgccgac atcgccgggc tccgcaacga cctgctctcc taccccaagg agatcgggcc
    11821 ggagggcgag caccacaacg cggtcgtggc cgtcgagcgg ttcctcggct gcgggacgca
    11881 gcaggccgcc gacatcgtcg ccgacctcgt cgaggcgcgc gtccggcagt tcgagcggac
    11941 cgccgagagc gagctgccga tcctcgccgc cgagtccggg ctggacgccg ccgcccgcga
    12001 cggcctcgcc cggtacgtcc gggcgatgcg cgactggacg gccggcgacc tgcgctggtc
    12061 cacgacgacc ggccggtacg cgccgcccgg cggcggcacc ggccccgccc cgccaccggc
    12121 cccggacacc gggttccgcg tcccgtccgg cccgtccggg ctcggcgcgg cggcggcccg
    12181 cccacccttc cggccggtgc gccccgcacc ggaccggcac aacgaggcac aaccagccat
    12241 ccccggaggt agcggcacat gaccgacccg cagctggccc tgagcacgcg ggcagcgcgc
    12301 aatctcgcga cgaccaccaa gtccgtgccg cagatgcagg gcatcacccc gcggtggctg
    12361 ctgaccctgc tgccgtgggt gcgggcggac gcgggctcct accgggtgaa ccggcggctc
    12421 acctacgagc tcggcgacgg gcgcgtcacg ttcgtcaacg acggcgccgc cgtccgcgtc
    12481 atccccggcg agctggcgga gctgccgcag ctcagcgggc tggacccgat ggtgctggac
    12541 gcggtcgccg gccgcttcgc gcagaccgag tacgcgcccg gcgacacgat cgccgccgcc
    12601 ggcgacccgc tcgaccgcgt ccacctcatc gcgcacggca aggtcgccga gaccgggacc
    12661 ggcgagtacg gcggcgagac gcagatcgcg atccgcgacg gcggcgactt cttcggcgac
    12721 gaggccctgc tcggcgacgc cggcacctgg ccgcatacgt tccgggccct caccccgacg
    12781 atcgtgctga cgctgtcccc ggccgcgatc gtggaggtca ccgagcggtc ggagacgctg
    12841 cgcgcccgcc tggaggagta ccgcaacgcg ccgaagccgc cgcagacccg gcacggcgag
    12901 gccgccatcg acctggcgtc cggccacgag ggcgagcccg cgctgcccgg cacgttcgtc
    12961 gactacgaga cctcgccccg cgagtacgag atgagcgtca cgcagacgct gctgcgcatc
    13021 cacacccggg tcgccgacct ctacaacgag ccgatggacc aggtcgagca gcagctccgc
    13081 ctcaccatcg aggagatccg cgagcggcag gagcacgagc tggtcaacaa ccgcgacttc
    13141 ggcctgctgc acaacgccga cctgcggcac cgcatccaga cccgcggcgg cccgcccacc
    13201 cccgacgaca tggacgagct gctcgcccgg cgccgcaaga cccgcttcta cctcgcccac
    13261 ccgagggcga tcgccgcgtt cggccgcgag tgcacccggc gcggcgtgta cccgggcacc
    13321 gccgagatcg agggcgggcg gcgcatccag gcgtggcgcg gcgtcccgat ctacccgtgc
    13381 gacaagatcc cggtcacccc gaccggcacc acgtcgatca tcgcgatgcg gacgggggag
    13441 gacgaccagg gtgtcatcgg cctgcggcgc accgggatcc ccgacgaggt gcagccgggc
    13501 ctgtcggtgc gcttcaccgg catcgacgac cgggcgatca tgtcgtacct ggtcagcgcc
    13561 tactactcgg ccgccgtgct ggtgcccgac gcgctcggtg tcctggagaa cgtcgagatc
    13621 ggccgctgac ggggggaggg ggcatgtcgg tggagacgtc cgcccggtcc gccgccgaga
    13681 tcctggcgtg gagccgggga ctggtggagc ccgcgctgcg gtccgtggtc ggggcgatgc
    13741 ccccggcgat gcgcggcatc gccgagttcc acttcggctg gcgggacgag gcgggccggg
    13801 ccgcggcggg ggcgggcggc aagtccgtcc gcccggcgct gacgctgctg gcggccgagg
    13861 cgtccggcgg gacggcggcc gccgccgtgc ccgccgccgt cgcggtcgag ctgacgcaca
    13921 acttctcgct gctgcacgac gacgtcatgg acggcgaccg cacccgccgg caccggccga
    13981 ccgcgtggac ggtgttcggg gtcagcgccg cgatcctcgc cggggacgcg ctgctcgccg
    14041 gcgcctacga ggcgctcgcg gaggcgccgt ccccggaccc ggcgggcgcg gtccgggtgc
    14101 tcagccgcgc ggtcctggag ctggtggagg ggcagagcgc cgacaccgcg ttcgaggacc
    14161 gcaccgacgt cacgctcgcc gagtgcctgg cgatggccgg cgggaagacc ggcgcgctgc
    14221 tcggcggcgc gtgcgcgctc ggcgccctgt acgggggcgg cgccgggcgc gcgggccggt
    14281 accgggcgtt cggcgagcgg ctcggcctgg cgttccagct ggtggacgac ctgctcggca
    14341 tctggggcga cccggaggtc acgggcaagc ccgtccactc cgacctgcgc aaccgcaaga
    14401 agtcgctgcc ggtggtggcg gcgctgacgt cggggacgcc ggcgggggag gagctggcgg
    14461 cgctgtacct gcggcggggg gcgctcgcgg gcgacgagcc ggcccgcgcc gccgcgctga
    14521 tcgaggcggc cggcgggcgg gcgtgggcgg cggcggaggc ggacgcgctg gtcgcgggcg
    14581 ccctcaccga gctggacgcg gccgacccgg tcccggcggc cgccggggag ctgcggtcgg
    14641 tggcgcacat gctcacccac cgggaccact gagggcgcac tgagggcccg cggtacgggc
    14701 gctgggaggc tgccggacag acgttgtcaa ccccgggaaa acccggcgtc gccgtcgtta
    14761 tagtgcgggt gtgccggacc ttcaccccct cgaacccacc gatccgcagc ggctcggcgg
    14821 ctaccgggtc accgggcgga tcggggaggg cgggcagggc gtcgtgtacg ccgccgtccc
    14881 cgacggcggc ggcgaccggg tcgcggtgaa gctgttccac gcgcagctga ccggcgaccc
    14941 gggcgcgctc gacaccttcg cccgggagct ggaggcggcc aagcaggtcg cccggttctg
    15001 caccgcccag gtgctggact cgggcgcgtt cggcaaccgg cgcttcatcg tcagcgagta
    15061 catcgacggg ccgccgctca gcagcgtcgt ccgggacggc gggccgcggt cgggcagcgc
    15121 cctggaccgg ctggcgatcg cgacggcgac ggcgctggtc gcgctgcacg acgccggggt
    15181 ggtgcaccgc gacgtcaagc cgcacaacgt gctgatcggc gcggacggcc cgcgcgtcat
    15241 cgacttcggc atctcgcggg cgctgtcggg cgcgcagacc gtggtgagcc gcgccgtcgg
    15301 cacccccgcg tacatggcgc ccgagcagct ccagccgggg gagctcgggc ccgcggtgga
    15361 cgtgttcgcg tgggcgtcga cgatggtgtt cgccgcgacg ggccgtccgc cgttcgggaa
    15421 cgagtccatc ccggtcgtga tgaaccggat cgcgcacgag ccgccgcgcc tggacggcgt
    15481 cgaggagccg ctgcgcgggc tgctcgccga gtgcctcgcg aaggacccgg cgcggcgccc
    15541 gacggcgcag aacgtgctgg accgcctcgt ccgccgctcc cagcagacgt ctcccggcgg
    15601 cgtccccgcg cccggccccg cgccggaacc ggcggtcgag gctgcggcgg acgtgtcgac
    15661 gctgccgcgc gaccggcggc gcaaccggag gcgtgcgggc gtcctggcgg gcgcgggcgc
    15721 cgcggtcgtc gcgggcgccg ccgtgttcgg gatcgtgcag atggcggacg gcgacacggg
    15781 cggcggcggc ccgcacgcga cgccgcaggg gacggcgggg acggccgcgg gccagggcgg
    15841 cacggcggag gcgggccacg cggcggtgcc gggaagcggg tcgccgagcg cgagcgcaag
    15901 cgcgggccgg agccccgctg cgggcccgag cacggcggcg tcgcgtccgg cgacgtcggg
    15961 gaagccgtcc ggcgggccgt cggcgagccc gtcctaccag cgggtcgagc tggggcccgg
    16021 ccacttctcg gcgtactgcg cgaagctcgg ctgggagtgg gaggagtacc ggaccgcgcc
    16081 ggcgccgggc gcgtactgcg tggcgcacaa gcgcgccgcg cagctgatgt cgaaggcgca
    16141 gctcgacgct ggatgccgct ggcggtacga cgacccccgc gcccggcact acttcaaggg
    16201 ccagtcgaac tactgctaca cgctgaagca ggtctcctag ccctggcggc gggcccggcc
    16261 gcggccgcgc gcggtggcgg ccaggccggc gatcacgatg acgccgacga ccaggtgcat
    16321 cgcggtcagc gccgcgaagg tgccgccgtg cgcggagcgc ggcccggtca gcgacacccc
    16381 gaggacgacc gccgcggtga tcgcccaggt gcgggccggg cgcttcgcgc ggcgctccat
    16441 gacggccagc agcccccagc cggccagccc cgccaccagc gaggacacga ccaccatgac
    16501 gggcccgacg tgccggccgc cggcgtgcat gccggcgccg aggacggggc cggcgaccac
    16561 ccagatggcg agcgcggcgg cggccgcggc ggcgacggtg agggagcgcc ggacggcggt
    16621 gcctccggtg gcgggacggg tctcggtcat ctcgttcatg gccgcaacga tcgccgtccg
    16681 gcgggcggcg gcgcatcggg cgcggggctg cggcgggtcc gtccgccggc cgggggcacc
    16741 ccctacttcg gtaggtgtcg cggcgcgcgg gcccgtccta cgctgacccc gtgaacagcg
    16801 agaacgcctg cgaggtggag cagcgcgacc cgcggctcgc cgccggttcg gccgtggtgg
    16861 tcgccacggt gggcgcgctc ggcgcgctga cggtgtgggg ccggtccggc gggccgccgg
    16921 gggcgctcgc cgtcgacatc gccgccgggg tgctggcctg cgtgctggcg cccgtcgtgc
    16981 tgtggcggcc ggtggcgggc acgctcgcgc tgaccgtgct cgccgcgctg tccccggcgg
    17041 cgacgcccgc ggcgacgttc ggcgcgctgc acgtcgcgca gcggcgccgg ttcccggtcg
    17101 cgctcgcggt cggcgcggcg ggcgtcgcgg ggcacgcggt gcaggggctc tggcggcccg
    17161 agggcggcat cacctacggc tggtggctgc tggtcgtcgc gctcgcgtac ggcgcgctgg
    17221 tcggctgggg cgcgctggcg caggcgcgcc gcgcgctgct cgcctcgctg cgcgagcggg
    17281 cccgccgcgc cgaggccgag caggggcggc gcgtcgccga ggcccggatg ctggagcgca
    17341 cccgcatggc ccgcgagatg cacgacgtcc tcgcgcaccg gctgtcgctg ctggccacct
    17401 acgcgggcgc gctggagtac cgtccggacg cgccgccgga gaagctcgcg caggccgccg
    17461 gggtcgtgcg cgccggggtg caccaggccc tcgacgagct gcgcgaggtg atcagcgtgc
    17521 tgcgggacga ggacgcccgc gacgacgacc gcccccagcc cgtcctcgcc gacctgccgg
    17581 cgctcgtcgc ggagtcccgc gacgcgggcg gcagcgtgca gctgcgggac gaggtggtcg
    17641 agcccgccgc gctgcccgcc gccgccgggc gcaccgcgta ccgggtcgtc caggaggggc
    17701 tgacgaacgc ccgcaagcac gcggcgggcc gcccggtgcg ggtggcggtc gagggccgtc
    17761 ccggcacccg gctggtgatc gacatccgga acccgctccc gccggacggt gccgtcccgc
    17821 tcgcccccgg caccgggacg ggcctggtcg ggctgaccga gcgggtgcag ctcgcgggcg
    17881 gccggctgga ccacgagatc gccgcggggg agttccggct gcgcgcctgg ctaccatggc
    17941 ccgcgtgaac cgccccctgc gcgtgctgat cgtcgacgac gacgccctcg tccgcgcggg
    18001 cctgtcgatg atgctggacg gcgtgcacgg gatctccgtc gccggggagg cggcggacgg
    18061 cgccgaggtg ccggaggctg cggacctgca cgcgcccgac gtcgtcctga tggacctgcg
    18121 gatgccgcgc gtcgacggca tcaccgccac ccgcgccctg cgcggccgcg accccgcgcc
    18181 cgaggtcatc gtcctcacca cgttcgacac cgacgagaac atcctgcacg cgctgcgcgc
    18241 cggggcgagc ggcttcctgc tgaaggacac cccgcccgcg cagatcgtcg aggcggtccg
    18301 gcgggtggcg gccggcgagc cgatcctgtc gccgcggatc acccgccggc tgatggaccg
    18361 ggccgccacc caggccggcg cctacgagcg cgcccgcgcc gcgctcggcc ggctcagccc
    18421 gcgcgagaac gacgtggtcg ccgcgatcgc ggcgggccgg tcgaacgccg agatcggcgc
    18481 cgcgctgttc atgagcgtgg cgaccgtcaa ggcgcacgtg tcgagcatcc tcaccaagct
    18541 ggacctcgac aaccgcaccc agatcgcgct gctcgcccac gacgccggcc tcgcctgaac
    18601 cggcgtcagg ccacggccac gcgcagcgtc gcggccgtca gcacgaggca cagcggggtg
    18661 tagagggcca ggttgagctt gtagaaggcc gaatccctgc gggcgccgac gcccagcgcc
    18721 cagacgacgc ccgcgcccgc gcggagggcg acgcccgcgg cgacggcgac ggtcccggcc
    18781 gccgggatcc agccggggac gccggagagg atcagtccgg cccgggccgg cacggcgatc
    18841 gcaccggccg tcaggacggc gacgagcggc gccagcaccc gcggagtgaa cgggacgtcg
    18901 gcgttcagca ggccctggga cagggtggtg acatcgcggg cgggccaggt gcggcccgtc
    18961 atccagtaca cgtgcaggag ggcgtcgaga ccgaggaccg cggcggcgag aagagccgcc
    19021 agttcgagaa tgctcatgac tggaagagga cgcggacgtc ccgcatcact cccgtgatcc
    19081 gcgtcactcc gccggagtga accgccggac gaaccggcgc agcacgacgg gaccgagcac
    19141 ccggcgcagt accggccccg cgaagcggac gcccgggacg cggagcccgg ccatgtaggc
    19201 gaaccgggtc gcgtccccgt cccttaccgc cgccatgccg aacaccagga aacggctctg
    19261 catcaggcac cagccgggac gcagcaccat gtcgaagcgc gcgcgcagac cggagcggcc
    19321 gcgcaccagc gcgcgcatcc gctcgctctc ccgctcggtg acgcgcaggg accggacgtc
    19381 cggcaccagg ccggggaacc cgccctccgg gtcgcccagc accgcccaca cgtcctcgaa
    19441 cgccgccggc aggaccgcct cctccagcag gacgccgggg aacgcggcgg ccagcgcgcg
    19501 gagccggcgc acgtcgtcca gctctccgag cggccaggtc acggcgggct cccttcgtcg
    19561 cgccagttca gccggaagcg cgcccgcgcc cggaacagcc gggaccggac ggtcccttcc
    19621 ggcacccgca gcatccgcgc cgcggtcgcc tcgtccagcc cctccaggtc gcgcagcacc
    19681 agcacggcgc gctgctcggg cggcagccgg tcgagcacgt cgcggacgtc ggcggccagc
    19741 gacgggtcgc cgggcgcggg caggtccgcc ggctcggcgg ggaccgaccg cgccgactgc
    19801 cgggcggccc ggaccgcctc ccggacggcg atgacccgca cccacccgag gagcgcggcg
    19861 gggtcgcgca gcgtcttcag gccccgcatg accgcgatga gcgtctcctg cgcggcgtcc
    19921 ggcgcgtcct gcagcgcgat cggcccgcag agccgccgca cgtacggggc gagcgcgtcg
    19981 agcacctcgt ccagcgccat caggtcgccg cgctgcgcgc gcctcacgac gtcgggatcg
    20041 ggcgcgctca ccggcccgac actacccccg aatgcctcga tagtatgttc gagtcgtgca
    20101 tgtcccgttc ctgtgccccc gcggccaccg cctcgtcccc ggccgcgtca tcgtcggctg
    20161 gtcgccctgc gtctgcccgc cctgcggcgg ccgcgcccgc ggcctgcgcg gccaccgcac
    20221 ctacctgtgc ctcgactgca aggacgagca cgtcaccacc aagtgctacc tgccgtacca
    20281 cgtccccgcc cagggcaccg cctaccgctg gccgtgacgc cggaggctag gctggcgatc
    20341 atgaccggac gatgggcgct gggcggcgac ctcgacgtcg ccaggatcgg gtacggcgcg
    20401 atgcggctgt cgggctggcc gggcggcccg cgccccgacc gctacaccgc cctcgccgtc
    20461 ctgcaccgcg ccgtcgagct cggcgtgaac cacctcgaca cctcgaacta ctactcccac
    20521 gacggggtgt ccgccaacga gctgatccgc gaggcgctgc acccctaccc ggacgacctg
    20581 gtgatcgtca ccaaggtcgg cgcgctcgtc gagggctccg acgtccacct gccggccggc
    20641 gagcacaccg gcctcacccc gtccggcctg cgccgcgccg tcgaggcgaa cctccgcacc
    20701 ctcggcctgg accgcctcga cgtcgtgaac ctccgcatgg gcctcttcgg gacgtccgag
    20761 gagtccctcg ccgagcccct ggagaccatg gccgcgctcc gcgacgaggg cctgatccgc
    20821 cacctcggcg tgtccaacgt cacgcccgcg caggtcgccg aggcccgcgg gatcgcgccg
    20881 atcgcctgcg tccagaacga gtacaacgtc tcccggcgcg acgacgaccc gctcgtggac
    20941 gcctgcgccg gagccggcat cgcctacgtg ccgttctccc cggtcggcgg cttccagccg
    21001 ctcaccgccg accacctcga caccgtcgcc gcccgccacg gcgcgaccgt cccgcaggtc
    21061 gccctcgcct ggctgctggc ccgctccccg aacatcctcc tcatccccgg caccggctcc
    21121 ccggcccacc tggaggagaa cctcgccgcc gccggcctcc gcctcacccc cgaggacctc
    21181 gccgacctcg cctgaccccc gccgcgggaa cccggaagcg gcctccgagg gataaccggt
    21241 gtagacaccg cgaaccctgg gaggcccccc gatgacagag ccgccgacgc gaccggccgc
    21301 gtggtgatcg gtatccgggc gcggccgggc cccgcggccg ggacggcgcg gggcgacgcc
    21361 gagccgatcc gcaggtccct cgcggaaccg gaggcgttca ccgccctgta cgaccggcac
    21421 gcgcccgcga tccaccggta cgtcgcgcgc cgcctcggcc ccgacgcagc cgacgacctg
    21481 atggccgaga cgttcctgat cgccttccgc aaacggtcgc gctacgacct ggcccgcgcc
    21541 gacgcccggc cctggctgta cgggatcgcg acccggctcg tcgcgcggca ccgcaaggcc
    21601 gagacctccc gctacctgct gctggaacgg ctcggcggcg agacggcggc cgaccccgtc
    21661 gacagcgagg cgcgggtgag cgcgcaggcg ctgcgcggcc cgctcgcccg ggcgctcgcc
    21721 ggcctgcccg cgatctaccg ggaaccgctg ctcctggtcg cctgggccga cctgagctac
    21781 gaggaggtgg ccgcggcgct ggagatcccc gtgggcaccg tccggtcccg gctgtcgcgc
    21841 ggccgggccc ggctccgcgc ggcgctcggc ggcgccgacc cgaccgagga ggacatcgat
    21901 ggatgagatg gcgctgctgc gcgaggccgg agccgacgtc gcgccgccca cggacgccgc
    21961 cctgcaggcg ggacgcgacc ggctcgccgc cgccgcgcgg cccgcccgcc ggcggccgcc
    22021 gcgcctgcgg aggcccgcgg ccctcggcct gctcgccgcg gccgccgcgg tggccggcgc
    22081 cgccgcgatc acgatggcgc aggtcgtcgc gccggacggc cacgggtccg ccacggccgc
    22141 cgccgcggag gtgctgcgcg acgccgcggc caccgcccgc ggcggccccc cggtcagacc
    22201 gtccgcgtac agctacacga gggaactgct cgtcttcccc ggcgagccgg gaaggcagtg
    22261 cgaggagacc tggctccggc gggacggctc gcttgcggcc ggaggcacct tcccggagcg
    22321 gcgtggtggc cattgcgacc cccacgaacc ggggcgctgg cttccgtccc tccgggacgg
    22381 cgacgccgac cggcgcccgc acgccgatgt ccgcaccctg ccgaccgtcc cgtccgcgct
    22441 ccgcgcgcgg ctgtactccg acgccgccca cggcaggggc cagaacgcgg acgacaaggg
    22501 gccgcgcgac cagctcgtct tcaaccgcat cggccggctg ctgcgcatgc cgctcccgcc
    22561 cgagctgcgg gccgcgctgt tccagacgct cgcgaccgtc cccggcgtcg acgtcgtccg
    22621 cggcgagagg gacgcgctcg gacggcaggg gatcgcgctg gcccggtcct tcggcgaccc
    22681 gggggacacg acccgcgtgg agatcatcct cgccccgggc acgtaccgct acctcggcat
    22741 gaaggcggtg caggacatgg gggcgccggc ccccttgacc cgcctctcgg ccctgctgac
    22801 caccgccgcc gtcacgacgc cctaccagcg cccctgagat ccccgcccgg ccccgggccg
    22861 gtcccggggc cgggcggggt cacgcggtcg gcgggagcgg gggcagcggg agcggcaggc
    22921 ccggcaggcc gtcgatgctg gtcgcgacgt gctccttctt gtggaagtac gcgtcgagcg
    22981 acgcgtcgtc ctcccgcgcg aaccgcgacg cgtgcagcgg gcggtcctcc ccgtacgtca
    23041 tgaacgggac ggcgtacccg caggtgtcgc ggatcttctc ggccttgacg acgatgatcg
    23101 cgcgcagccc gtgcacggtc acgtcgatgt ccgggaagtg ccgcatcagc ccgtcccagc
    23161 gcggatcgtc ccggaacacc ggctcgcccc gcccgtgcac ccgcacgatg ttcggcgggc
    23221 cctcgaacgc gcaccacatc agcgtgatcc ggccgttctc ccgcaggtgg gcgatcgtct
    23281 cggcgttgct gcccgcgaag tcgaggtagg ccagcgtgag ctcgtcgagc accgcgaacg
    23341 acccggtcag ccccttcggc gacaggttga cggtcccgtc cccgtccagc ggcgccgtcg
    23401 cggtgaagaa gatgtgctgc gcctcgatga acgcccgcaa cctgccctca atacgctcat
    23461 aactcttccc catcccccga gtatgaccac ccgcccggcc taggatgagg gtgcggtggc
    23521 cgggaggagt tcggcgtggc cgatacagcc atgactcgcc gagcaaatgc cgggagcccg
    23581 acgctgtctg gtagctgacc gcctcctgcc ctcagaacca gaggcctacg attcggacgc
    23641 aggctcgtta ctcggtggcg gttctagtag ctcctccgtg aagggtgatc cgtggccgga
    23701 gttggacctt gacggcgccc tgcttgaagg cgccatcggt cgccttgctg gaccagatgt
    23761 aggcctcgcc gggggagagg gccgccagct tcgagggggt caggccggtc agcgaggtga
    23821 tcgccttctg catgtgcttg agccaggccg gcgaggtgaa cttatgcagg atcacatggt
    23881 tcgagagctc gatcagcttg atggggaccg atggcggatc ctgactcgcg acgagtacgc
    23941 tcatgccctt gtgacgcatc tcgcggacgc tcgccacgag ttcgtcgacc aggtccgggc
    24001 tgtcgatgta cttgtgcgcc tcgtcgaaga ccacgagctt gttgaaccgc ccgttctcgt
    24061 tctgcgcttc ggcgaacaat tgcatgagga caacgaacaa tcccagggcg tcgtcctttt
    24121 cgacgaactc gtcgcgcaga tcgacgatga tcacacggcc gggccggacg agctccttga
    24181 cacgggcctc gtcgtcgatg tagtcggagg cgagatcgag gcgttgctgt gcgagttgct
    24241 tcaggtggtc tggcagggcc gagtggtcga cggcgtcgcg gatgacgtcc aggcggagat
    24301 cgcggcgatg cgctctcatg atccgctgga gctggcggat gtaggtggac tggtttccga
    24361 cagcacccat gaggaaacgc cagtgctctg cgcgtagctc cgcggagctg aacttgagcg
    24421 gccggacctg gatctctgga tactcagcga tacgctgatc cagctgatct tcgggtacga
    24481 gcatgatgac atcgctcaga gcggcgggct cgacgccgta cgttgccctc agcgccgcga
    24541 cctggtcggt gctgtcgttc gcgctgacca tgcttgtgaa ttccggagcg taatccagtg
    24601 tctggctgta gtggaaaacg atcgttgcga gggggttggg gagcgcgttg accggcggtg
    24661 ccggtagcga tg
//
