LOCUS       NZ_CP053892            21773 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7884652
            Orig. end                         :: 7906425
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..21773
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="20"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21773
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21773
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11773](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11773
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(156..683)
                     /locus_tag="ACTIVE_RS35355"
                     /old_locus_tag="ACTIVE_7097"
     CDS             complement(156..683)
                     /EC_number="2.7.1.12"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046316 - gluconokinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0046177 - D-gluconate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854191.1"
                     /locus_tag="ACTIVE_RS35355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7097"
                     /product="gluconokinase"
                     /protein_id="WP_173099056.1"
                     /transl_table=11
                     /translation="MSNPPETKVVLIAGVSGSGKTTVGGMLAERLGWDYAEADAFHSPA
                     NIAKMRAGHPLTDADRAPWLRAIAAWIDDRLSSGRPGVVTCSALKRAYRDELAGGRPAV
                     RTVLLDGDRDVIAERMRRRHGHFFGAGLLDSQFADLERPAPDEHVLTVPITDSPEETVD
                     RIIKALDLSPKH"
     gene            complement(687..1268)
                     /locus_tag="ACTIVE_RS35360"
                     /old_locus_tag="ACTIVE_7098"
     CDS             complement(687..1268)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854190.1"
                     /locus_tag="ACTIVE_RS35360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7098"
                     /product="isochorismatase family protein"
                     /protein_id="WP_173099057.1"
                     /transl_table=11
                     /translation="MGKKALIIVDVQNDFCEGGSLAVGGGAGVATAISGHVAGRGGGYA
                     HIVATRDFHLDPGDHFSDRPDFVDSWPPHCVIGTPGADFHPNLALARIEAVFSKGRETA
                     AYSGFEGVSDDDVPLADWLASRGVDAVDVVGIATDHCVRATAVDAARAGLRTTVLLDLT
                     AGVAKTTVDRALDELGREGVILTGDPVVSD"
     gene            complement(1345..2664)
                     /locus_tag="ACTIVE_RS35365"
                     /old_locus_tag="ACTIVE_7099"
     CDS             complement(1345..2664)
                     /EC_number="6.3.4.21"
                     /GO_function="GO:0004514 - nicotinate-nucleotide
                     diphosphorylase (carboxylating) activity [Evidence IEA]"
                     /GO_function="GO:0004516 - nicotinate
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018655865.1"
                     /locus_tag="ACTIVE_RS35365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7099"
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="WP_281382710.1"
                     /transl_table=11
                     /translation="MDVDDGTALLTDRYELTMLQAALRSGTAGRRAVFEVFARSLPAGR
                     RYGVVAGVGRLLDAIEAFRFDTAELEFLTAGGIVDEPTAQWLEKYRFSGNVWGYAEGDC
                     YFPESPILVVEGTFAEAVLLETVALSILNHDCAIASAASRMVQAAHDRPIIEMGSRRTH
                     ERAAVAAARAAYIAGFTTTSNLEAGRLYGVPTAGTSAHSFTLLHDSERHAFEAQLASLG
                     DGTTLLVDTYDVERAVRTAVELAGPSLGAVRIDSGDLGVMARRVREQLDSLGAHDTRIV
                     VTGDLDEYGIAALAAAPVDGYGVGTSLVTGSGAPTASLVYKLVARTDGPDEDAPMRPVA
                     KRSTGKPSRGGRKSAVRRIDAHGTAYAETVSIGETAPGRRDRALLVPLVRDGEIVGRES
                     LRDARDRHVRAVAELPATALQLSKGEPALPTEFVEGGPRA"
     misc_feature    2659..2674
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     gene            2918..3214
                     /gene="clpS"
                     /locus_tag="ACTIVE_RS35370"
                     /old_locus_tag="ACTIVE_7100"
     CDS             2918..3214
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="clpS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017624981.1"
                     /locus_tag="ACTIVE_RS35370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7100"
                     /product="ATP-dependent Clp protease adapter ClpS"
                     /protein_id="WP_173099058.1"
                     /transl_table=11
                     /translation="MSTAPAPVELERPEIEEDVRADRPWLAIVWNDPINLMSYVTYVFQ
                     TVFGYPKSKAEKLMLDVHHKGRAVVAKGTREEMERDVEILHSYGLWATVKRDD"
     misc_feature    complement(3235..3254)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.27"
                     /tool="antismash"
     gene            3292..3819
                     /locus_tag="ACTIVE_RS35375"
                     /old_locus_tag="ACTIVE_7101"
     CDS             3292..3819
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854187.1"
                     /locus_tag="ACTIVE_RS35375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7101"
                     /product="DUF2017 domain-containing protein"
                     /protein_id="WP_173099059.1"
                     /transl_table=11
                     /translation="MSNVKKTREGVAVRLEPEEAALVRALMEQLVTLLGDVPGGDGELA
                     SLGIAEDAVKPDDPVLARLFPDAYREDGEAAGEFRRYTEMGLRDGKREAARTVLDGLKG
                     AAGKIVLDREQAQIWLRALNDVRLALGTRLDISEEWYEEAERLDPRDPRTAMFAAYDWL
                     TMLQEGLVRALW"
     misc_feature    3850..3867
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 18.77"
                     /tool="antismash"
     gene            3929..4963
                     /locus_tag="ACTIVE_RS35380"
                     /old_locus_tag="ACTIVE_7102"
     CDS             3929..4963
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF041045.1"
                     /locus_tag="ACTIVE_RS35380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7102"
                     /product="sensor histidine kinase"
                     /protein_id="WP_173099060.1"
                     /transl_table=11
                     /translation="MIAYPGGPPETAAAAPAAVRPDGRRDALVHRAIPYGWPRELALTA
                     VPFLRGGWRAGDAVVVIASEPVRVTLREELGVEVCAGIEFIDSGEWFGGPMRALAGYHD
                     RMRADWWPRGGLRLLAEPVWDGLSPLETREWQRHESLLNVVFAGTPTTIMCAYDAVALP
                     PDVLDAMARTHPELAGPDGPRPSPRFTDPAEFYAECNAGALPPPPDAAAHRTFGPGGLP
                     SLRAFLTVEAMRLGLPESRTLPFVLAANEVATLIIRTGGGCGSARLWTREGELVCEVAD
                     PGRALADRFLGYAPPRGPGPAAGPDGRDADGAMWAVRRLCRLVQIRSGTDGTRIRMHVR
                     LDGE"
     misc_feature    5041..5061
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.64"
                     /tool="antismash"
     gene            5049..5468
                     /locus_tag="ACTIVE_RS35385"
                     /old_locus_tag="ACTIVE_7103"
     CDS             5049..5468
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854186.1"
                     /locus_tag="ACTIVE_RS35385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7103"
                     /product="M67 family metallopeptidase"
                     /protein_id="WP_173099061.1"
                     /transl_table=11
                     /translation="MLTIERALVEKIVAHARADHPDEACGIIAGPIGSDRPVRYVAMTN
                     AERSPTFYRFDSQEQLKLWREMDDRDEEPVVIYHSHTATEAYPSRTDISYASEPNAHYV
                     LVSTRDESTEEFRSYRIVDGEVTEEEVRIVDAYGA"
     gene            5503..5676
                     /locus_tag="ACTIVE_RS35390"
     CDS             5503..5676
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS35390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_173099062.1"
                     /transl_table=11
                     /translation="MAAGNGGNAAGKLVDMWTSGDVTGARRRVPCSAVPPVQSFLFGHS
                     RAEVVYDCSPTR"
     gene            5759..6031
                     /locus_tag="ACTIVE_RS35395"
                     /old_locus_tag="ACTIVE_7104"
     CDS             5759..6031
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629417.1"
                     /locus_tag="ACTIVE_RS35395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7104"
                     /product="MoaD/ThiS family protein"
                     /protein_id="WP_173099063.1"
                     /transl_table=11
                     /translation="MAIEVRIPTILRNLTDGAKAVEGKGGTLDELFADLDTRHPGLRAR
                     LVDDKGLRKFVNVYLNDEDVRFLGGLETEVSDGDGVTILPAVAGG"
     gene            6052..6999
                     /locus_tag="ACTIVE_RS35400"
                     /old_locus_tag="ACTIVE_7105"
     CDS             6052..6999
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013151438.1"
                     /locus_tag="ACTIVE_RS35400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7105"
                     /product="cysteine synthase"
                     /protein_id="WP_173099064.1"
                     /sec_met_domain="PALP (E-value: 7.8e-65, bitscore: 218.2,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFDSLLDSLGGTPLVGLPRLSPSEDVRLWAKLEDRNPTGSVKDR
                     PAFYMIEKAEKDGLLTPGCTILEPTSGNTGISLAMVAKLRGYQMVCVMPENTSAERRQL
                     LEMWGARIISSPAAGGSNEAVRVAKGLAAENPDWVMLYQYGNEANALAHYETTGPEILA
                     DLPSVTHFVAGLGTTGTLMGVGRYLREQVPGVKIVAAEPRYGELVYGLRNIDEGFIPEL
                     YDDSVLTTRFSVGSRDALRRTRELLEQEGIFAGISTGGALHAAIGMASKAVKAGERADI
                     VFVVADGGWKYLSTGAYGGTLEEAEARLEGQLWA"
     gene            7203..8003
                     /locus_tag="ACTIVE_RS35405"
                     /old_locus_tag="ACTIVE_7106"
     CDS             7203..8003
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854181.1"
                     /locus_tag="ACTIVE_RS35405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7106"
                     /product="thioesterase family protein"
                     /protein_id="WP_173099065.1"
                     /transl_table=11
                     /translation="MSGFEAATAVKRIGEGRYEVDLDGDFGFAEALNGGYLMAVLDRAA
                     VDASPHEHPVSTAATFLRPAKPGRAELLVDARKTGRTAATSLVSLVQGDRPVVEALITT
                     GTLTGAAEPVFAGPAPAADVPPLEECTSMLPAEGTEGFAGQVDMRFDRSTMGWLDGTPS
                     GRPEIRAWFRLRDGYAPDAFSLALAVDALPPVALNLGSKGWAPTVELTWHMRAVPAPGW
                     LAVHGTGRLLSDGWFDEEVEVWDSAGRLVAQSRQIARVGTGARK"
     gene            8220..9092
                     /gene="murI"
                     /locus_tag="ACTIVE_RS35410"
                     /old_locus_tag="ACTIVE_7107"
     CDS             8220..9092
                     /EC_number="5.1.1.3"
                     /GO_function="GO:0008881 - glutamate racemase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="murI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018655845.1"
                     /locus_tag="ACTIVE_RS35410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7107"
                     /product="glutamate racemase"
                     /protein_id="WP_246342377.1"
                     /transl_table=11
                     /translation="MSATGDLDAMQPSSGGRSDLPIGIFDSGFGGLTVARAILDQLPNE
                     PIVYLGDSARQPYGPRPIAEVRAFALEMLDRLVDEGVKMLVIACNSASSAMLRDARERY
                     DVPVVEVINPATRRAARATSNGRVGLIATNATVTSRAYDDAFAAAPHIELVSAACPRFV
                     EFVEAGVTMGPDLLDAARGYLRPIVDAGCDTLILGCTHYPLLTGVISYVVGDGVTLVSS
                     ADETAKDVYRVLHDQGLARDEGRPRPRHRFRATGDPGVFAELGRRFLGPEIDVVETAPE
                     SVLNKALTT"
     gene            9123..9872
                     /locus_tag="ACTIVE_RS35415"
                     /old_locus_tag="ACTIVE_7108"
     CDS             9123..9872
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012854179.1"
                     /locus_tag="ACTIVE_RS35415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7108"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_173099066.1"
                     /transl_table=11
                     /translation="MRVTVIGCSGSFPGPDSPASSYLVEADGFSLLVDIGNGAIGTLQR
                     FHDVLDIDAICISHLHPDHCLDLTVYWIARTYCPYGRAPRIPVYGPPGTAEHMIKAYEL
                     APNPEMDDTFDFRTLGPGRLEIGPFAVTTALMNHPVETYGMRIEHGGSVLAYSGDSGHS
                     DALVELARGADLFLCEAAFAQRPDLPPDMHLTGREAGEHAERAGAGRLVLTHLLPWNDP
                     AQTLAEAKDSGFGGPIELAEVGAVYDL"
     gene            10001..11773
                     /locus_tag="ACTIVE_RS35420"
                     /old_locus_tag="ACTIVE_7109"
     CDS             10001..11773
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024640.4"
                     /locus_tag="ACTIVE_RS35420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7109"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_173099067.1"
                     /sec_met_domain="T2TS (E-value: 4e-13, bitscore: 47.7,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDGARRAEEGAAGPGARVPRLELILFAESRDGFVVLAEGGEIVP
                     LRLPAERRPGRDAGDGLGALVARAAKERFGLDVEYLGLLAAEPGPRRPRLTVGAVARGA
                     QDFGRAGTRSRVLSMADLEARRGEVRDADLFAAAHGWYRASAVARDLPVRIRRAVDRSL
                     LYLENHRSIEDGRWGWNLYMDGHSLGLLSTAEGILAHLHAGVTGDELSRPVASLVGMQN
                     PDGGWQVRKSLVGAQSDQSVTESTCAVLWALHGVGRSSSDPVIADGLAWLESLQHDGGW
                     PSAAPLDGAAPELRVFPTTCAVRTLARYGRGDAAKGVAWLRAAQNDDGGWGSRPAVAGQ
                     TQASSATHTAYTVIALLTAGVAATDPAVGRAVAYLRASFDPAKDEPWESSQDHSLINPA
                     TSARLEFRHFATPWALAALAMAGAGLDDPVILTGTDKLLGLQDPEGTWRSSLTGGARAM
                     WATHDALYALRAVSDTLRETVAPVVVDPYRSRERAALEHCAAELLAGDDRAPAAGARRW
                     WQTAWLSVLTVVVALVTLDRLAVFDALTSAKAGKAWAWAATAAVTLLVAVAPNVVGEEY
                     RVWRSRRGGRRPGG"
     gene            11774..12610
                     /locus_tag="ACTIVE_RS35425"
                     /old_locus_tag="ACTIVE_7110"
     CDS             11774..12610
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207: inositol monophosphatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012673.4"
                     /locus_tag="ACTIVE_RS35425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7110"
                     /product="inositol monophosphatase"
                     /protein_id="WP_173099068.1"
                     /transl_table=11
                     /translation="MIVSESQPRPGGAWEAQAAVALGCARSAGAYLRTQFGAASPRRYQ
                     GAHDVQLAADVEAQRRIVAGLTERFPGYGVLAEEGPVRRWPDAEHVWLVDPLDGTNNFG
                     YGIAHCAISISLFRRRRPVLALVVDPLLRREFVAVEPPSGEPPAAPPGPCVPLRRSTIS
                     LVTNYSAAGRVWGDRMSEALGGKCKRVTSLWAPALDLALVSCGQLDGMICHEGDLLDVG
                     GGTLLVRAAGGHVLDLSGEPFHAHGSMYRRPVSFVAARDERLARELLEYARTAAAG"
     gene            complement(12646..13371)
                     /locus_tag="ACTIVE_RS35430"
                     /old_locus_tag="ACTIVE_7111"
     CDS             complement(12646..13371)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS35430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7111"
                     /product="hypothetical protein"
                     /protein_id="WP_173099069.1"
                     /transl_table=11
                     /translation="MTLGELSSRLSAALGPAGKGARTGADGLRAALAPFAAPRATRRLL
                     CAALRDERWMAEMLAASYRHPNGFDKIVLLADAGCQLRLHVWRDDACETRVENVHNHRW
                     DFSSVLLLGGYRFQEFVPDPDGPDFHTYGYASERGAAEYSLEPLGPRGLTCSFDAHLGP
                     GTSYTLASDVLHRVSNVPGRLTVSLVLQGPHQAGTSVLVFAEDRLEAGEELHRAGFSRG
                     SLRRLLEQLVDELAIPQPN"
     gene            complement(13399..13887)
                     /locus_tag="ACTIVE_RS35435"
                     /old_locus_tag="ACTIVE_7112"
     CDS             complement(13399..13887)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS35435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7112"
                     /product="hypothetical protein"
                     /protein_id="WP_173099070.1"
                     /transl_table=11
                     /translation="MPIEIERKFLLGETPDWSHPVLAGADVIEYEQVYLRVAGGEQVRI
                     RRGVRDGRADHRLARLRRLSDGVREVEESELDAAEYARLRADRDPRREIVAKVRRCFRW
                     DGLLFELDDIRRPAARACHLLELQVASLEEPYTLPGFLVIDREVTTEPAFSNAAIALG"
     misc_feature    complement(13860..13873)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.83"
                     /tool="antismash"
     misc_feature    13860..13874
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.47"
                     /tool="antismash"
     misc_feature    13917..13930
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.82"
                     /tool="antismash"
     misc_feature    complement(13959..13974)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            14001..14735
                     /gene="rph"
                     /locus_tag="ACTIVE_RS35440"
                     /old_locus_tag="ACTIVE_7113"
     CDS             14001..14735
                     /EC_number="2.7.7.56"
                     /GO_function="GO:0004549 - tRNA-specific ribonuclease
                     activity [Evidence IEA]"
                     /GO_process="GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rph"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131199.1"
                     /locus_tag="ACTIVE_RS35440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7113"
                     /product="ribonuclease PH"
                     /protein_id="WP_173099071.1"
                     /transl_table=11
                     /translation="MARPDDRAPDQLRPVRIQRGWLDHAEGSVLVEFGRTRVLCAASVQ
                     DSVPRWRRDSGLGWVTAEYAMLPRATNTRNDRESIKGRVGGRTHEISRLIGRSVRACLD
                     FKALGENTVQLDCDVLQADGGTRTAAITGAYVALADAVSWMRERKMLRGNPLVTSVSAV
                     SVGVVAGEARLDLCYEEDSAAGTDMNVVCTGDGRFVEVQGTAEGAPFDRAELDALLDLA
                     AGGCAELTRLQDAALGKEKQAP"
     gene            14732..15385
                     /gene="rdgB"
                     /locus_tag="ACTIVE_RS35445"
                     /old_locus_tag="ACTIVE_7114"
     CDS             14732..15385
                     /EC_number="3.6.1.66"
                     /GO_function="GO:0035870 - dITP diphosphatase activity
                     [Evidence IEA]"
                     /GO_function="GO:0036222 - XTP diphosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="rdgB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629423.1"
                     /locus_tag="ACTIVE_RS35445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7114"
                     /product="RdgB/HAM1 family non-canonical purine NTP
                     pyrophosphatase"
                     /protein_id="WP_173099072.1"
                     /transl_table=11
                     /translation="MTRIVLATRNAGKIVELERILDGIAVAGLAAFPDAPEVPETEPTF
                     EGNALLKARAIAAHTGLPAVADDSGLCVDALNGMPGVLSARWSGRFGDATGDKDATGDK
                     DAANLRLVLDQLADVRDGLRGAAFVCAAALVVPANGDRSAVEHTVEGRMRGAIVREPRG
                     TGGFGYDPVFLPDGETRTTAEMAPEEKDAISHRGKAFRALAGLLPDALAAAGRL"
     misc_feature    complement(15467..15482)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.75"
                     /tool="antismash"
     gene            15526..16065
                     /locus_tag="ACTIVE_RS35450"
     CDS             15526..16065
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS35450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_173099073.1"
                     /transl_table=11
                     /translation="MIDKGRIRRGPLLALAGVAGAGALAAGIWASADSGSAPQVRPVAE
                     RNALTHTASPAPVPPVASARPCASARPSTRTPEPAPPKKARPATPPGVRSASPRPVPPH
                     TTPKPTASPTKARPVPSPTKARPVPSPTHCGSRPGVPAPSRTATPRPVPPGAHAPRPVP
                     SEPPVKPSPVPSAPRR"
     gene            16079..16591
                     /locus_tag="ACTIVE_RS35455"
                     /old_locus_tag="ACTIVE_7116"
     CDS             16079..16591
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02983.1"
                     /locus_tag="ACTIVE_RS35455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7116"
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_173099074.1"
                     /transl_table=11
                     /translation="MSAQEIRGAEITFDEFVTATAGRLLRTAVFLVYDRHLAEDLLQTA
                     YERVARKWKRVSGGNPEAYARRVLVNLAIDENKRRARRRDTPVGTVADVERLAGPPPAA
                     GVAGGDLDEVLRALPAKQRAVVVLRYWCDLGEQEIADTLGISRGTVKSHTARAMAALRE
                     HMKEGRA"
     gene            16588..17085
                     /locus_tag="ACTIVE_RS35460"
                     /old_locus_tag="ACTIVE_7117"
     CDS             16588..17085
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS35460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_7117"
                     /product="hypothetical protein"
                     /protein_id="WP_173099075.1"
                     /transl_table=11
                     /translation="MNDELEALLRDHYRAAADHVTADPGTVRRFQDAGRAAVAEPRTRW
                     RWAFPVLAAAVTAAVLVTIALFLWPGGGRPATPRPMGPPASPSVPGPQVPTEPPSARPS
                     PAPTSGTAGRVPPPGRSTPEASPTPRMPRTTTPLPGGTTPRPTTSPGAHGRPPAAVSPT
                     PS"
     gene            complement(17123..17446)
                     /locus_tag="ACTIVE_RS35465"
                     /old_locus_tag="ACTIVE_7118"
     CDS             complement(17123..17446)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024857.4"
                     /locus_tag="ACTIVE_RS35465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7118"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_173099076.1"
                     /transl_table=11
                     /translation="MEPLRIVRTDEPAGLALIGELDSARHAVLARALETALAELPPDRE
                     FHLGLGGLDFIDLGGIALLGDAAWSRACGAPVVLDRTPPDMRAVLETVGWGTLPGLCFG
                     DPA"
     misc_feature    17420..17438
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.14"
                     /tool="antismash"
     gene            complement(17451..18401)
                     /locus_tag="ACTIVE_RS35470"
                     /old_locus_tag="ACTIVE_7119"
     CDS             complement(17451..18401)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629426.1"
                     /locus_tag="ACTIVE_RS35470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7119"
                     /product="sensor histidine kinase"
                     /protein_id="WP_246342378.1"
                     /transl_table=11
                     /translation="MSMEDGAPKKRRALEHRAFVYGGTDHFLAVTEPFLRSGLEAGEAV
                     VAVARRSNLSALHDLFGDGAGIEWVDAAGFYLHPVRTLRDYQALVNKFAPRPVCALAEP
                     VWTGWDERQTLEWIRYESLINEVFKDSGARALCPYDGEALPPRIIEEARRTHPMVVTDG
                     PALASGAYVAPAAFGANCDRHRRFTRPDDAEYFAVDDADLHALRSFVAERALLHGLAKR
                     PAQNLVTAVNEVAANAVQHGLPPVGMWIWRDGPELLCEIGDNGLWRPAPSALTGFIPPR
                     SALQRGFGLWTVRLLVDLVELRAGWDGTFVRLHIR"
     gene            complement(18401..19315)
                     /locus_tag="ACTIVE_RS35475"
                     /old_locus_tag="ACTIVE_7120"
     CDS             complement(18401..19315)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018655839.1"
                     /locus_tag="ACTIVE_RS35475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7120"
                     /product="MEDS domain-containing protein"
                     /protein_id="WP_173099077.1"
                     /transl_table=11
                     /translation="METPWFAKRPVKDIRPGDHSWLAYSGPEERDSVIGPFVREGLETN
                     EKVVYVTDAPAELLPGLGPRHRVDVEALGRTGQLRIISRRDACLDRRGGFAPGKMLETI
                     GREVDAAFGQGFRAARFTTDYSCLIGEPGRSGLAVMLGCEHGVGNAVSPSTMAMAICQI
                     DRRACPPDELAALRDTHEVLVEVNPEFDDGILKISRTFEPNGLRVEGELDAARHQVFAE
                     QLAQVCLARRRVHLDFADLGFIDLGGLNLLAQQATVLPADEALVLDHLPPDVENVIEMV
                     GWHRLPGLERGRERAFPETEGIA"
     gene            complement(19396..20376)
                     /locus_tag="ACTIVE_RS35480"
                     /old_locus_tag="ACTIVE_7121"
     CDS             complement(19396..20376)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018655838.1"
                     /locus_tag="ACTIVE_RS35480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7121"
                     /product="sensor histidine kinase"
                     /protein_id="WP_173099078.1"
                     /transl_table=11
                     /translation="MSESFTHCVLPYDRVDDLLDGALPFLREGAEAGDRVVALCGIARE
                     MLLRDALGAEAASVEFVEPAAWYSHPARTLADCLSDADDTAWRGRRLRLLGEPVVWASR
                     PPLEVLEWQRVEAMLNVAFRGTGAAIMCPYSSSLPAGVVAAGRRTHPETVRGARSVANP
                     LYMDPWAYSAKCDGEPLPPPPADADELDVVRPDLYWLRAYVTEYAHRTPLPDEDLQRLL
                     VAVTEVVTNALRHGAPPIVLRMWTEASGADPALVCEVTDEGRWDPGAGRGLVPPRPSGT
                     ATGGRFGLWAVRLLCSIVQIRTGPGGSTVRLRLRLPAVPAAMNGV"
     misc_feature    20491..20506
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.34"
                     /tool="antismash"
     misc_feature    complement(20494..20512)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    20498..20512
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.02"
                     /tool="antismash"
     misc_feature    complement(20502..20516)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.01"
                     /tool="antismash"
     gene            complement(20503..21204)
                     /locus_tag="ACTIVE_RS35485"
                     /old_locus_tag="ACTIVE_7122"
     CDS             complement(20503..21204)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633592.1"
                     /locus_tag="ACTIVE_RS35485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_7122"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_246342379.1"
                     /transl_table=11
                     /translation="MMNKSGRPDPAAGRASRGRRRGSPDTRAQILDVARTRFLADGYAK
                     VTLRSIAAEADVDAALISYFFGSKKGLFGAVLGLMANPPDVLAAALPGDPATLPERILA
                     AMLATWDDPERGRPLILMVRAATQDAELTRLLRDVVGREMIDRIAEHIGGPDARHRAAA
                     CGAQLAGVIFGRYVLAVEPLASMTADELIAVLAPGMRAVLYRRARPDRRTRPDGGVRPG
                     ARTHPASRRTM"
     misc_feature    complement(20632..20634)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gcgagcgaag ccgggttcga gcttgcgaga acccgatcgc gcagcgaggc ccccagggcc
       61 gagccggagc gatgcagcga tcgcacgcag cgcccgttga agggaaggcg ttctagcgcc
      121 tgaccgccga gggcactgca ttcaagcacg acggatcagt gcttcggcga caggtccagg
      181 gccttgatga tgcggtccac cgtctcctcg ggggagtcgg tgatcgggac ggtcagcacg
      241 tgctcgtccg gcgcggggcg ctccaggtcg gcgaactggc tgtccagcag gccggcgccg
      301 aagaagtgcc cgtgccgccg gcgcatccgc tcggcgatga cgtcgcggtc gccgtcgagc
      361 agcacggtcc ggacggcggg ccgcccgccc gccagctcgt cgcggtaggc gcgcttgagc
      421 gccgagcagg tcacgacgcc gggccgcccg gagctcagcc ggtcgtcgat ccaggcggcg
      481 atcgcgcgca gccagggcgc gcggtcggcg tcggtcagcg gatggccggc ccgcatcttg
      541 gcgatgttcg cgggggagtg gaacgcgtcg gcctccgcgt agtcccagcc gagccgctcg
      601 gcgagcatgc cgccgacggt ggtcttgccg ctgccggaca cgccggcgat caggacgacc
      661 ttggtttcgg gggggttgct cacggttcag tcgctcacga ccgggtcgcc ggtgaggatg
      721 acgccctcgc gtccgagctc gtccagggcc cggtcgacgg tggtcttggc gacgcccgcc
      781 gtcaggtcca gcaggacggt ggtgcgcagc ccggcgcggg cggcgtcgac ggcggtggcg
      841 cggacgcagt ggtcggtggc gatgccgacg acgtcgacgg cgtcgacgcc gcgggacgcg
      901 agccagtccg ccagcggcac gtcgtcgtcg gagacgccct cgaagccgct gtaggcggcc
      961 gtctcgcggc ccttgctgaa caccgcctcg atccgggcga gcgccaggtt cgggtggaag
     1021 tcggcgccgg gcgtgccgat cacgcagtgc gggggccagc tgtcgacgaa gtcggggcgg
     1081 tcggagaagt ggtcgccggg gtcgaggtgg aagtcgcggg tcgcgacgat gtgcgcgtag
     1141 ccgccgcccc gcccggcgac gtgaccggag atggccgtgg ccacgcccgc gccgccgccg
     1201 acggcgagcg agccgccctc gcagaagtcg ttctgcacgt ccacgatgat cagagccttc
     1261 ttgcccatga ccgctcctct gccggtatct ccccgatgtc gacgctaccc cagcgccgcc
     1321 gccgcccctg cggccgtacg gccgtcaggc gcgcgggccg ccctcgacga actcggtcgg
     1381 cagggccggc tcgcccttgg acagctgcag cgcggtcgcc gggagctccg cgaccgcgcg
     1441 gacgtgccgg tcgcgggcgt cgcgcagcga ctcgcgcccg acgatctcgc cgtcgcggac
     1501 gagcgggacg agcagggcgc ggtcgcgccg ccccggcgcg gtctcgccga tcgacaccgt
     1561 ctcggcgtag gcggtgccgt gcgcgtcgat gcgccggacg gcgctcttgc ggccgccgcg
     1621 gctgggcttg ccggtggagc gcttcgcgac gggccgcatg ggcgcgtcct cgtccgggcc
     1681 gtcggtgcgg gcgacgagct tgtagacgag cgaggcggtc ggcgcgccgg acccggtgac
     1741 cagggacgtc cccaccccgt agccgtccac gggcgcggcg gcgagcgcgg cgatgccgta
     1801 ctcgtcgagg tcgccggtca ccacgatccg ggtgtcgtgc gcgcccagcg agtcgagctg
     1861 ctcgcggacg cggcgggcca tcacgccgag gtcgccgctg tcgatgcgga cggcgccgag
     1921 ggacggcccg gcgagctcca ccgccgtccg gacggcccgc tcgacgtcgt aggtgtcgac
     1981 cagcagcgtc gtcccgtcgc cgagggacgc cagctgcgcc tcgaacgcgt gccgctcgct
     2041 gtcgtgcagc agcgtgaacg agtgcgcgct cgtcccggcc gtgggcacgc cgtagaggcg
     2101 gcccgcctcc aggttcgacg tggtggtgaa cccggcgatg taggcggcgc gggcggcggc
     2161 gacggcggcg cgctcgtggg tgcggcgcga ccccatctcg atgatcggcc ggtcgtgcgc
     2221 cgcctgcacc atccgggacg cggcggacgc gatcgcgcag tcgtggttga ggatcgacag
     2281 ggcgacggtc tccagcagca ccgcctcggc gaaggtcccc tcgaccacca ggatcggcga
     2341 ttccgggaag tagcagtcgc cttcggcgta gccccagacg ttcccggaga agcggtactt
     2401 ctccagccac tgcgccgtgg gctcgtccac gatcccgccg gcggtgagga actccagctc
     2461 cgcggtgtcg aaccggaacg cctcgatcgc gtccagcagc cgcccgacgc ccgcgacgac
     2521 gccgtagcgg cgcccggcgg gcaggctgcg ggcgaacacc tcgaacaccg cgcgccgccc
     2581 ggccgtgccg ctgcgcagcg cggcctgcag catcgtcagc tcgtaccggt cggtgagcag
     2641 ggcggttccg tcgtcaacgt ccacaggtgg aaccctaagg ccaggtgcgg gcaccatgga
     2701 gatgcgggcc gccgcgcccg gcgcggatcg caccggggac ggtggagatc gccccggaag
     2761 gcgcgggggc gcatagcatc ggtgcggtgg gcggaccgac aacgcggggg aagggggaga
     2821 cgcggccgat gagcgtcacg agcagggcga gcgggccggg gcccgagagc acgccgagcg
     2881 gggcggggct catgagcacg ccgagcggag tgaggtcatg agcacggcac ccgcgcccgt
     2941 cgagctggag cggcccgaga tcgaggagga cgtccgcgcg gaccggcctt ggctggcgat
     3001 cgtctggaac gacccgatca acctgatgtc gtacgtcacg tacgtgttcc agaccgtctt
     3061 cggctatccc aagagcaagg ccgagaagct gatgctggac gtccaccaca agggccgcgc
     3121 cgtcgtggcc aagggcaccc gcgaggagat ggagcgggac gtcgagatcc tgcactccta
     3181 cgggctgtgg gccaccgtca agcgggacga ctgatcccga cgggctctcc ggggcgcggg
     3241 gcggacgtcc ccctcgggag ccaccgaagc ctttctgggc ggagcgatcc gatgagcaac
     3301 gtgaagaaga cccgcgaggg cgtcgccgta cggctggagc cggaggaggc ggcgctggtg
     3361 cgggcgctga tggagcagct ggtcacgctc ctcggcgacg tccccggcgg ggacggcgag
     3421 ctggcctcgc tgggcatcgc cgaggacgcc gtcaagccgg acgacccggt gctggcgcgg
     3481 ctgttccccg acgcctaccg cgaggacggc gaggcggcgg gggagttccg ccgctacacc
     3541 gagatggggc tgcgggacgg caagcgcgag gcggcccgga cggtgctgga cgggctgaag
     3601 ggggcggccg ggaagatcgt cctcgaccgg gagcaggcgc agatctggct gcgcgcgctg
     3661 aacgacgtgc ggctggcgct cggcacgcgg ctggacatca gcgaggagtg gtacgaggag
     3721 gccgagcggc tcgatccgcg cgatccgcgg acggcgatgt tcgccgcgta cgactggctg
     3781 acgatgctgc aggaggggct cgtccgcgcg ctctggtagc cggtccgtcc gcacccggcc
     3841 agcacggaat caccgattgt ccggatacgg acgcggtgcg tggtgtcaac tggaggcgag
     3901 aggacgccgc cgacgcggag gagatccgat gatcgcctat ccgggcgggc cgccggagac
     3961 cgcggccgcc gccccggccg ccgtccggcc ggacggccgg cgggacgcgc tggtgcaccg
     4021 ggcgatcccg tacgggtggc cgcgcgagct ggcgctgacc gccgtcccgt tcctgcgggg
     4081 cgggtggcgc gcgggcgacg ccgtcgtcgt gatcgcctcc gagccggtcc gggtgacgct
     4141 gcgcgaggag ctcggcgtgg aggtctgcgc ggggatcgag ttcatcgact cgggcgagtg
     4201 gttcggcggc ccgatgcggg cgctcgccgg gtaccacgac cggatgcgcg ccgactggtg
     4261 gccgcgcggc gggctgcggc tgctcgccga gccggtgtgg gacgggctgt cgccgctgga
     4321 gacgcgcgag tggcagcggc acgagtcgct gctgaacgtg gtgttcgcgg gcacccccac
     4381 cacgatcatg tgcgcgtacg acgcggtggc gctgccgccg gacgtgctgg acgcgatggc
     4441 ccgcacgcat cccgagctgg ccggcccgga cgggccgcgg ccgagccccc ggttcaccga
     4501 cccggccgag ttctacgccg agtgcaacgc gggcgcgctg ccgccgcccc cggacgccgc
     4561 cgcgcaccgc acgttcgggc cgggcgggct gccgtcgctg cgcgccttcc tcaccgtgga
     4621 ggcgatgcgg ctcgggctgc cggagagccg gacgctgccg ttcgtgctgg ccgccaacga
     4681 ggtggccacg ctgatcatcc ggaccggcgg cgggtgcggc tcggcgcggc tgtggacgcg
     4741 cgagggcgag ctggtctgcg aggtggccga tcccggccgc gcgctcgccg accggttcct
     4801 cggctacgcc ccgccgcgcg gccccggccc ggccgcgggc ccggacgggc gggacgccga
     4861 cggcgcgatg tgggcggtgc gccggctctg ccggctcgtg cagatccgct ccggcactga
     4921 cggcacccgg atccgcatgc acgtccgcct cgacggcgag tgagcgcgca cggcgggtga
     4981 gcgcgcactg cggccgagcg cacccggcgg gtgaggggcg cgccggccgg ggcggtagcc
     5041 ttcggggcat gctgacgatc gagcgtgccc tcgtcgagaa gatcgtcgcg catgcgcgcg
     5101 ccgaccaccc ggacgaggcg tgcggcatca tcgccggccc gatcgggtcg gaccggcccg
     5161 tccggtacgt cgcgatgacc aatgccgagc ggtccccgac cttctaccgg ttcgactcgc
     5221 aggagcagct gaagctgtgg cgcgagatgg acgaccggga cgaggagccg gtggtgatct
     5281 accactcgca caccgcgacc gaggcgtacc cgtcccgcac cgacatctcc tacgcctccg
     5341 agccgaacgc gcactacgtg ctcgtgtcca cccgcgacga gagcaccgag gagttccggt
     5401 cgtaccggat cgtcgacggc gaggtgaccg aggaagaggt ccggatcgtc gacgcctacg
     5461 gcgcctgacc gccgggcctg atcgcggggg tgcggagcgc cgatggcggc ggggaacggc
     5521 gggaacgcgg ccggtaaact ggtcgacatg tggacgagcg gggacgtgac gggcgcgcgg
     5581 cgccgcgtcc cgtgctccgc ggtgccaccc gtacagagct tcctgttcgg gcattcgcgc
     5641 gccgaggtcg tctacgactg ttcgccgacg cgctgatcct gcccggaatt cccccgctgc
     5701 ccgcccggtt gtgacgcaga gggcggggag ccccgtacga ccgaaggaga tcatcgcgat
     5761 ggcgatcgag gtccggatcc cgacgatcct gcgcaacctc accgacggcg ccaaggccgt
     5821 cgagggcaag ggcggcacgc tcgacgagct gttcgccgac ctggacaccc ggcaccccgg
     5881 gctgcgcgcc cggctggtgg acgacaaggg cctgcgcaag ttcgtcaacg tctacctcaa
     5941 cgacgaggac gtgcgcttcc tcggcggcct ggagaccgag gtctccgacg gcgacggcgt
     6001 gacgatcctg ccggccgtcg ccggcggctg agccgggctg gacgagctca catgcgattc
     6061 gactcgctgc tggactcgct cggcggcacc ccgctggtgg ggctgccgcg gctgtcgccg
     6121 agcgaggacg tccggctctg ggccaagctc gaggaccgca acccgaccgg gtcggtgaag
     6181 gaccgtcccg ccttctacat gatcgagaag gcggagaagg acgggctgct cacccccggc
     6241 tgcacgatcc tggagccgac gtccggcaac accggcatct ccctcgccat ggtcgcgaag
     6301 ctgcgcggct atcagatggt gtgcgtgatg ccggagaaca cctcggcgga gcgccgccag
     6361 ctgctggaga tgtggggcgc gcggatcatc tcctcgcccg ccgcgggcgg gtcgaacgag
     6421 gccgtccggg tggcgaaggg cctggcggcc gagaaccccg actgggtgat gctgtaccag
     6481 tacgggaacg aggccaacgc gctggcgcac tacgagacga cgggcccgga gatcctcgcg
     6541 gacctgccgt cggtgacgca cttcgtcgcg ggcctcggca ccaccggcac gctgatgggc
     6601 gtcggccgct acctgcgcga gcaggtgccc ggcgtcaaga tcgtcgcggc ggagccgcgg
     6661 tacggcgagc tggtgtacgg gctgcgcaac atcgacgagg gcttcatccc cgagctgtac
     6721 gacgactccg tcctgacgac ccggttctcc gtcgggtcgc gggacgcgct gcgccgcacc
     6781 cgcgagctgc tggagcagga gggcatcttc gccgggatct ccaccggcgg ggcgctgcac
     6841 gccgcgatcg gcatggcgag caaggcggtg aaggcgggcg agcgcgccga catcgtgttc
     6901 gtcgtcgcgg acggcggctg gaagtacctg tccaccggcg cgtacggcgg caccctggag
     6961 gaggccgagg cgcgcctcga aggccagctc tgggcctgac cgggccgtcc ccgggcctgc
     7021 acccggggcg gctccgggcc tgatcgggac cctgcgtccc gccctgtccc gagccctgtc
     7081 cgggtgagcg tgatcccggc cacggcgcgg tccccgaccg gcacggtaca gttcatattc
     7141 gaacgtgatt ctagaaccgt gccggccggg tggacgcccg ccggccggac ggggagcagg
     7201 cgatgagcgg gttcgaggcg gccaccgcgg tgaagcggat cggcgagggc cggtacgagg
     7261 tcgacctgga cggcgacttc ggcttcgccg aggcgctgaa cggcggctac ctgatggccg
     7321 tcctcgaccg cgccgccgtc gacgcctccc cgcacgagca ccccgtctcc acggccgcga
     7381 cgttcctgcg gcccgccaag cccggccgcg ccgagctgct cgtcgacgcc cgcaagaccg
     7441 ggcggaccgc cgcgacctcg ctggtcagcc tggtccaggg cgaccgcccc gtggtcgagg
     7501 cgctgatcac caccggcacc ctcaccggcg ccgccgagcc cgtgttcgcc gggcccgcgc
     7561 ccgccgccga cgtcccgccg ctcgaggagt gcacgagcat gctccccgcc gagggcaccg
     7621 agggcttcgc cgggcaggtc gacatgcgct tcgaccgttc cacgatgggc tggctggacg
     7681 ggaccccgag cggccgcccg gagatccgcg cctggttccg gctccgcgac ggctacgccc
     7741 ccgacgcctt ctccctcgca ctcgccgtcg acgcgctccc gcccgtcgcg ctcaacctcg
     7801 gctccaaggg ctgggcgccg accgtcgagc tcacctggca catgcgcgcc gtcccggcgc
     7861 ccggctggct cgccgtgcac ggcaccggcc ggctgctgtc ggacggctgg ttcgacgagg
     7921 aggtcgaggt ctgggactcc gccgggcgcc tcgtcgcgca gagccggcag atcgcccgcg
     7981 tcggcaccgg cgccaggaag tgacccgcgc cgggaagcga cctgtcggga cgtgaccggc
     8041 gccggggagt gattcgcgcc gagaagtgac ccgcgcgacg cacgcgaccg gcgtttcgcg
     8101 cgcccggcga cgggatcacg cgcgcatccc gtgaactgga gcgttttcca acgggtgacg
     8161 gtgtgatgtc caacgcatga cgcacctgcc cgggggtaag tcgcctagcc tgtaggacca
     8221 tgtcagcgac cggtgacctc gatgcgatgc agccctcttc cggtggccgg tcggaccttc
     8281 cgatcgggat cttcgacagc ggtttcgggg gcctcaccgt ggcccgcgcg atcctcgacc
     8341 agctgccgaa cgagccgatc gtctacctcg gcgactcggc ccgccagccg tacgggccgc
     8401 gccccatcgc cgaggtccgc gcgttcgcgc tggagatgct cgaccggctc gtcgacgagg
     8461 gcgtgaagat gctggtgatc gcctgcaaca gcgccagctc ggcgatgctg cgcgacgccc
     8521 gcgagcgcta cgacgtcccg gtcgtcgagg tgatcaaccc cgccacccgg cgcgcggccc
     8581 gcgccacctc caacggacgg gtcgggctga tcgccaccaa cgccaccgtc accagccgcg
     8641 cctacgacga cgcgttcgcc gccgccccgc acatcgagct ggtcagcgcg gcgtgcccgc
     8701 ggttcgtcga gttcgtcgag gcgggcgtga cgatgggccc ggacctgctg gacgcggcgc
     8761 gcggctacct gcggccgatc gtggacgcgg gctgcgacac cctcatcctc ggctgcacgc
     8821 attacccact gctgaccggc gtcatctcgt atgtcgtcgg cgacggggtc acactggtgt
     8881 cgagcgccga cgagaccgcc aaggacgtgt atcgagtgct gcacgaccag gggctggccc
     8941 gcgacgaggg gaggccccgg ccacggcacc ggttccgcgc gaccggtgac cccggggtgt
     9001 tcgccgagct cggccggcgc ttcctcgggc cggagatcga cgtggtggag accgcgcccg
     9061 aatccgtcct gaacaaggct ctgaccacct gattcctcgg ggacacaaga ggaggagtga
     9121 gcgtgcgggt cacagtgatc ggctgctccg gcagtttccc ggggccggac agccccgcgt
     9181 ccagctacct ggtcgaggcg gacgggttct cgctgctcgt cgacatcggc aacggtgcga
     9241 tcggcacgct ccagcggttc cacgacgtgc tggacatcga tgcgatctgc atctcgcacc
     9301 tgcaccccga ccactgcctg gacctcaccg tctactggat cgcgcggacg tactgcccgt
     9361 acggccgcgc cccgcgcatc ccggtgtacg gcccgcccgg gaccgccgag cacatgatca
     9421 aggcgtacga gctcgcgccg aacccggaga tggacgacac gttcgacttc cggacgctcg
     9481 gccccggccg gctggagatc ggcccgttcg ccgtgacgac cgcgctgatg aaccatccgg
     9541 tcgagacgta cgggatgcgg atcgagcacg gcggcagcgt cctggcctac tcgggggaca
     9601 gcgggcacag cgacgcgctc gtggagctgg cgcgcggcgc cgacctgttc ctgtgcgagg
     9661 cggcgttcgc gcagcggccg gacctgccgc cggacatgca cctgacgggc cgggaggcgg
     9721 gcgagcatgc ggagcgcgcg ggcgcgggcc ggctggtcct gacgcacctg ctgccgtgga
     9781 acgacccggc gcagaccctc gccgaggcca aggacagcgg tttcggcggc ccgatcgagc
     9841 tcgccgaggt cggcgcggtg tacgacctct gatcgccgcc ggaacgcggc cgtgactgtg
     9901 cacgaacgca cagtcgcgac agttcgggcg tgagagcatg accgcggacg tctgaaccgg
     9961 tgggtcgcgg ggcgcaccgg accgactcgc gggagtggtc gtgagcgacg gggcacgccg
    10021 ggcagaagag ggggccgcgg ggccgggcgc ccgggtcccc cggctggaac tgatcctttt
    10081 cgcggagagc cgggacggct tcgtcgtcct ggcggagggc ggggagatcg tcccgctgcg
    10141 gctgccggcg gagcggcgcc ccggccggga cgccggggac ggcctcggcg ccctcgtcgc
    10201 ccgggcggcg aaggagcggt tcggcctcga tgtcgagtac ctcggcctgc tggcggccga
    10261 gccgggcccg cggcgcccgc ggctgaccgt cggcgccgtg gcgcgcggcg cgcaggactt
    10321 cggacgcgcc gggacccgca gccgcgtcct gtcgatggcc gacctcgaag cgcgccgcgg
    10381 cgaggtccgc gacgccgacc tgttcgccgc cgcgcacggc tggtaccgcg cgtcggcggt
    10441 ggcgcgggac ctgccggtcc ggatccggcg ggccgtcgac aggtcgctgc tctacctgga
    10501 gaaccaccgc tccatcgagg acggccggtg gggctggaac ctctacatgg acggccactc
    10561 cctcggcctg ctgtccaccg cggagggcat cctcgcgcac ctgcacgccg gggtgaccgg
    10621 cgacgagctg agccggccgg tcgcgtcgct ggtcggcatg cagaacccgg acggcggatg
    10681 gcaggtgcgc aagtcgctcg tcggcgcgca gtccgaccag tcggtgaccg agagcacctg
    10741 cgccgtcctg tgggcgctgc acggcgtcgg gcggagcagc tccgacccgg tcatcgccga
    10801 cgggctcgcc tggctggagt cgctccagca cgacggcgga tggccgtccg ccgcgcccct
    10861 ggacggcgcc gcgccggaac tgcgggtgtt ccccacgacc tgcgccgtcc gcaccctcgc
    10921 ccggtacggg cgcggcgacg cggccaaggg ggtggcgtgg ctgcgggcgg cgcagaacga
    10981 cgacggcggc tgggggtccc ggccggccgt cgcggggcag acgcaggcgt cgtccgcgac
    11041 gcacaccgcc tacaccgtca tcgccctgct caccgccggg gtggcggcga ccgacccggc
    11101 cgtcgggcgg gccgtcgcgt acctgcgcgc gtccttcgac ccggccaagg acgagccgtg
    11161 ggagagctcg caggaccact cgctgatcaa cccggcgacg tcggcccgcc tggagttccg
    11221 gcacttcgcg acgccgtggg cgctcgccgc gctcgcgatg gcgggcgccg gcctcgacga
    11281 cccggtcatc ctgaccggca ccgacaagct cctcgggctg caggacccgg aggggacgtg
    11341 gcgctcgtcc ctcaccggcg gggcgcgcgc gatgtgggcg acgcacgacg ccctctacgc
    11401 gctgcgggcc gtctccgaca cgctgcgcga gaccgtggcg cccgtcgtcg tggacccgta
    11461 ccggtcgcgg gagcgcgccg cgctggagca ctgcgcggcg gagctgctgg ccggcgacga
    11521 ccgggcgccc gcggccggcg cgcggcgctg gtggcagacg gcgtggctgt cggtcctgac
    11581 cgtcgtcgtg gcgctcgtca ccctggaccg gctcgccgtc ttcgacgccc tgacctcggc
    11641 gaaggcgggc aaggcgtggg cctgggccgc gaccgccgcg gtcaccctgc tcgtggcggt
    11701 ggcgccgaac gtcgtcgggg aggagtatcg ggtctggcgg agccggcgcg gcggccggcg
    11761 tccgggaggc tgagtgatcg tgtcggagtc gcagccgcgc cccggcggcg catgggaggc
    11821 gcaggccgcg gtggcgctcg gctgcgcccg gtcggcgggc gcctacctgc ggacccagtt
    11881 cggggcggcg tcgccccgcc gctaccaggg cgcccacgac gtccagctcg ccgccgacgt
    11941 cgaggcgcag cggcggatcg tcgccgggct caccgagcgg ttccccgggt acggcgtcct
    12001 cgccgaggag gggccggtcc ggcggtggcc ggacgccgag cacgtctggc tggtcgaccc
    12061 gctcgacggc accaacaact tcggctacgg catcgcgcac tgcgcgatct cgatctccct
    12121 cttccggcgg cggcggcccg tcctcgcgct cgtcgtcgac ccgctcctgc ggcgcgagtt
    12181 cgtcgccgtg gagccgccgt ccggggagcc gcccgccgcg ccgcccggcc cgtgcgtccc
    12241 gctgcgcagg tccacgatct cgctggtcac gaactactcg gcggccgggc gcgtctgggg
    12301 cgaccggatg agcgaggcgc tcggcggcaa gtgcaagcgg gtcacgtcgc tgtgggcgcc
    12361 cgcgctggac ctcgcgctgg tctcctgcgg gcagctcgac ggcatgatct gccacgaggg
    12421 cgacctgctg gacgtcggcg gcgggaccct gctcgtccgc gccgccggcg gccacgtcct
    12481 ggacctgtcc ggcgaaccgt tccacgcgca cgggtcgatg taccggcggc cggtgtcgtt
    12541 cgtcgccgcc cgcgacgagc ggctggcccg cgagctcctg gagtacgcga ggacggcggc
    12601 ggccggctag cggggcggct cagttgggcg gctcagccgg gcggctcagt tgggctgcgg
    12661 gatcgccagc tcgtccacga gctgctccag tagccgccgc agggagccgc gggagaaccc
    12721 cgcccggtgc agttcctcac ccgcttcgag ccggtcctcg gcgaacacca ggacggacgt
    12781 ccccgcctgg tgcggccctt ggagcaccag gctcaccgtg agccgccccg ggacgttcga
    12841 cacccggtgg agcacgtcgg acgccagcgt gtacgacgtc cccggcccga gatgggcgtc
    12901 gaaggagcag gtgaggccgc gcggcccgag cggctccagc gagtactccg ccgccccgcg
    12961 ctccgacgcg tacccgtagg tgtggaagtc cgggccgtcc gggtcgggga cgaactcctg
    13021 gaagcggtag ccgccgagca ggagcaccga ggagaagtcc cagcggtggt tgtggacgtt
    13081 ctcgacccgc gtctcgcacg cgtcgtcccg ccagacgtgc aggcgcagct ggcacccggc
    13141 gtccgccagc aggacgatct tgtcgaagcc gttcgggtgc cggtacgagg ccgccagcat
    13201 ctccgccatc caccgctcgt cgcggagcgc ggcgcacagc agccggcggg tggcgcgcgg
    13261 cgcggcgaac ggcgccagcg cggcgcgcag cccgtccgcg cccgtcctcg cgcccttgcc
    13321 ggccggtccg agggccgccg acagccggct cgacagctca ccgagcgtca tggcgcctcc
    13381 cgggaacgag gccacgggtc agccgagcgc gatcgcggcg ttggagaacg cgggttccgt
    13441 ggtcacctcg cggtcgatga cgaggaagcc gggcagggtg tagggctcct ccaggctggc
    13501 gacctggagc tccagcagat ggcaggcgcg cgcggcgggc cgccggatgt cgtccagctc
    13561 gaacagcagg ccgtcccagc ggaagcagcg ccggaccttg gcgacgatct cgcgccgcgg
    13621 gtcccggtcc gcgcgcagcc gcgcgtactc cgccgcgtcc agctcgctct cctcgacctc
    13681 ccggacgccg tccgacagcc ggcgcagccg cgccagccgg tggtcggcgc ggccgtcccg
    13741 gacgccgcgg cggatccgga cctgctcgcc gccggccacc ctcaggtaga cctgctcgta
    13801 ctcgatgacg tccgctccgg ccagcaccgg atgcgaccag tcgggcgtct cgccgagcag
    13861 gaacttgcgt tcgatctcta tgggcatcag tccgcgccgc tcactcgccg gggatcttct
    13921 cccagaccaa cccatcggcc gacgggtgtc aacatgcggt gagatacgtg tgaccgcggg
    13981 cgggcactag ggtggtgcgc atggcacgcc ccgatgatcg cgcacccgac cagctccggc
    14041 ccgtccgcat ccagcgcggc tggctcgacc acgcggaggg gtcggtgctc gtcgagttcg
    14101 gccgcacccg cgtgctgtgc gcggcgtccg tgcaggactc ggtgccgcgc tggcgccgcg
    14161 actccgggct cggctgggtc accgccgagt acgcgatgct gccgcgcgcc accaacaccc
    14221 gcaacgaccg cgagtccatc aagggccggg tcggcggccg cacgcacgag atctcccggc
    14281 tgatcggccg gtccgtccgg gcctgcctgg acttcaaggc gctcggcgag aacaccgtcc
    14341 agctcgactg cgacgtgctg caggccgacg gcggcacccg cacggccgcg atcaccggcg
    14401 cgtacgtcgc gctcgccgac gcggtgtcct ggatgcgcga gcgcaagatg ctgcgcggga
    14461 acccgctggt cacctcggtc tccgcggtca gcgtcggcgt cgtcgcgggg gaggcccggc
    14521 tcgacctgtg ctacgaggag gactccgccg ccggcaccga catgaacgtg gtgtgcaccg
    14581 gcgacggcag gttcgtcgag gtgcagggca ccgccgaggg cgcccccttc gaccgcgccg
    14641 agctggacgc gctgctcgac ctcgccgcgg gcggctgcgc cgagctgacc cggctgcagg
    14701 acgcggcgct gggcaaggag aagcaggccc cgtgacgagg atcgtgctgg cgacccgcaa
    14761 cgcgggcaag atcgtcgaac tggagcggat cctcgacggc atcgccgtgg cgggcctcgc
    14821 cgcgttcccg gacgcccccg aggtgcccga gaccgagccg acgttcgagg gcaacgcgct
    14881 gctgaaggcc cgcgcgatcg ccgcgcacac cggcctgccc gccgtcgccg acgactccgg
    14941 cctgtgcgtc gacgcgctga acggcatgcc cggcgtgctg tcggcccgct ggtccgggcg
    15001 gttcggcgac gccaccggcg acaaggacgc caccggcgac aaggacgccg cgaacctgcg
    15061 gctcgtcctc gaccagctcg ccgacgtccg cgacggcctg cgcggcgccg cgttcgtgtg
    15121 cgcggcggcg ctggtcgtcc ccgcgaacgg cgaccgcagc gcggtcgagc acaccgtcga
    15181 gggccggatg cgcggcgcca tcgtccggga gccgcgcggc accggcggct tcggttacga
    15241 ccccgtcttc ctgccggacg gcgagacccg caccaccgcg gagatggcgc cggaggagaa
    15301 ggacgcgatc agccaccggg gcaaggcgtt ccgcgcgctg gcgggcctgc tgcccgacgc
    15361 gctcgccgcc gccggccgcc tgtagcgcgg gccgcctgga gtgcggggcg gcccgtccgc
    15421 cccgcgttcg cgccgccggg aaagtttctc cgggccgatg acaacctgat cgcccccggc
    15481 gggggttctc aagggtgtac ggacaccgtc ccctcgagga gcaacatgat cgacaagggt
    15541 cgcatccgcc gcgggccgct gctcgcgctg gccggcgtgg ccggcgcggg cgcgctcgcc
    15601 gccgggatct gggcgtcggc cgactccggc tcggcaccgc aggtcaggcc ggtcgcggag
    15661 cggaacgcgc tgacgcacac cgcgagcccg gccccggtgc cgccggtggc gtccgcgcgg
    15721 ccgtgcgcat cggcgcggcc gtccacccgc accccggagc cggcgccgcc gaagaaggcg
    15781 cggccggcca cgccgcccgg cgtgcggtcc gcgagcccgc gccccgtccc gccgcacacc
    15841 acgccgaagc cgacggcgtc cccgacgaag gcgcgtccgg tgccgtcccc gacgaaggcg
    15901 cgtccggtgc cgtcgccgac gcactgcggg tcgcggccgg gcgtcccggc cccgtccagg
    15961 acggcgacgc cgcgtccggt gccgcccggc gcgcacgccc cgcggccggt gccgtccgag
    16021 ccgccggtga agccgtcgcc cgtcccctcg gcgccccgga ggtagccgcc tgtccaccat
    16081 gagcgcccag gagatccgcg gggcggagat cacgttcgac gagttcgtga ccgccaccgc
    16141 gggccggctg ctgcgcaccg ccgtgttcct cgtctacgac cggcacctcg ccgaggacct
    16201 gctgcagacc gcctacgagc gcgtcgcgcg caagtggaag cgggtgtcgg gcggcaaccc
    16261 ggaggcgtac gcccgccggg tgctggtcaa cctcgccatc gacgagaaca agcggcgggc
    16321 gcgccgccgc gacactccgg tcggcacggt ggcggacgtg gagcgcctcg ccgggccgcc
    16381 cccggccgcg ggggtcgccg ggggagacct ggacgaggtg ctccgcgcgc tgcccgccaa
    16441 gcagcgcgcg gtggtcgtgc tgcgctactg gtgcgacctc ggggaacagg agatcgccga
    16501 caccctcggg atctcccggg ggacggtgaa gagccacacc gcgcgggcca tggcggcgct
    16561 gcgggagcac atgaaggagg gccgggcgtg aacgacgagc tcgaagccct gctgcgcgac
    16621 cactaccggg cggccgccga ccacgtcacc gcggacccgg gcacggtccg caggttccag
    16681 gacgcgggcc gcgcggcggt ggcggagccc cggacccgct ggcggtgggc gttcccggtg
    16741 ctcgcggcgg cggtgaccgc ggcggtgctg gtgacgatcg cgctgttcct gtggccgggc
    16801 ggcgggcggc ccgcgacgcc gcggccgatg ggaccgcccg cctccccgtc cgtcccgggg
    16861 ccgcaggtgc cgacggaacc gccgtcggcc cgcccgtcgc cggcgccgac gagcggcacc
    16921 gcaggacgcg tccccccgcc cggccggagc acgcccgagg cgtcgcccac cccgcgcatg
    16981 ccgaggacca cgacgcccct gccgggcggg acgactccga ggccgacgac gtcgccgggc
    17041 gcccacggcc ggccgccggc cgccgtgtcg ccgacgccca gctgacgcgg gacccgcgat
    17101 ggcggccccg ccggcggacg ggtcaggcgg ggtcgccgaa gcagaggccg gggagcgtgc
    17161 cccagccgac cgtctccagg acggcgcgca tgtccggcgg cgtccggtcc aggacgacgg
    17221 gcgcgccgca cgcgcggctc cacgccgcgt cgccgagcag cgcgatcccg ccgaggtcga
    17281 tgaagtcgag cccgccgagg ccgaggtgga actcgcggtc gggcggcagc tcggccagcg
    17341 cggtctccag cgcgcgggcg agcaccgcgt ggcgggcgga gtccagctcg ccgatcagcg
    17401 ccagaccggc gggctcgtcc gtgcggacga tcctcagcgg ctccacgcgg ctacctgatg
    17461 tgcagccgga cgaacgtgcc gtcccagccg gcccgcagct ccaccaggtc gaccagcagc
    17521 cgcaccgtcc acagcccgaa gccgcgctgc agcgccgagc ggggcgggat gaagccggtg
    17581 agggcgcttg gcgcggggcg ccacagcccg ttgtcgccga tctcgcacag cagctccggg
    17641 ccgtcccgcc agatccacat cccgaccggc ggcaggccgt gctgcaccgc gttcgccgcg
    17701 acctcgttca ccgcggtgac gaggttctgc gcgggccgct tggcgaggcc gtgcagcagc
    17761 gcccgctcgg cgacgaacga gcgcagcgcg tgcaggtcgg cgtcgtcgac cgcgaagtac
    17821 tccgcgtcgt cggggcgggt gaagcggcgg tgccggtcgc agttcgcgcc gaacgcggcc
    17881 ggggcgacgt aggcgccgct ggccagggcg ggcccgtcgg tcaccaccat cgggtgggtg
    17941 cgccgcgcct cctcgatgat ccggggcggc agcgcctcgc cgtcgtaggg gcacagcgcg
    18001 cgcgcgccgg agtccttgaa cacctcgttg atcagcgact cgtagcggat ccactccagc
    18061 gtctgccgct cgtcccagcc cgtccacacc ggctcggcca gtgcgcacac ggggcgcggc
    18121 gcgaacttgt tcaccagggc ctggtagtcg cgcagggtcc ggacgggatg caggtagaac
    18181 ccggccgcgt ccacccactc gatcccggcg ccgtcgccga acaggtcgtg cagcgccgac
    18241 aggttggacc ggcgggcgac cgcgacgacg gcctcgcccg cctccagccc ggaccgcagg
    18301 aagggctcgg tcaccgccag gaagtggtcc gtgccgccgt acacgaacgc cctgtgctcc
    18361 agcgcccgcc gcttcttcgg cgccccgtcc tccatgctca tcaggcgatg ccttccgtct
    18421 cggggaacgc gcgttcccgg ccgcgctcga gaccgggcag ccggtgccag ccgaccatct
    18481 cgatgacgtt ctccacgtcg ggcggcaggt ggtccaggac cagcgcctcg tcggccggca
    18541 gcacggtcgc ctgctgcgcc agcaggttca gcccgccgag gtcgatgaag ccgaggtcgg
    18601 cgaagtcgag gtggacgcgc cgccgggcca ggcacacctg ggccagctgc tcggcgaaca
    18661 cctggtgccg ggcggcgtcc agctcgccct cgacccgcag cccgttcggc tcgaacgtgc
    18721 ggctgatctt caggatcccg tcgtcgaatt cggggttcac ttccacgagc acctcatgcg
    18781 tgtcacgcag ggcggcgagc tcgtcgggcg ggcaggcgcg ccggtcgatc tggcagatcg
    18841 ccatcgccat cgtgctgggc gacaccgcgt tgccgacgcc gtgctcgcag cccagcatca
    18901 cggcgaggcc ggagcgtccc ggctcgccga tcaggcagct gtagtcggtg gtgaaccggg
    18961 cggcccggaa gccctggccg aacgccgcgt ccacctcccg gccgatcgtc tccagcatct
    19021 tgcccggcgc gaagccgccc cgccggtcga ggcaggcgtc ccggcgggag atgatccgca
    19081 gctggcccgt cctgccgagg gcctccacgt ccacgcggtg ccgcgggccg aggccgggca
    19141 gcagctcggc cggggcgtcg gtcacgtaga cgaccttctc gttggtctcc agcccctccc
    19201 ggacgaaggg gccgatgacg ctgtcgcgct cctcggggcc gctgtaggcc agccagctgt
    19261 gatcgcctgg ccggatgtct ttgacgggtc gcttggcgaa ccagggtgtc tccatggcct
    19321 gcccatcgag gtcggttcgg attcgttcag cgtacgcctc atggaggttc tcggaagccc
    19381 aacgcatcga gttcctcaca ctccgttcat cgcggccggt acggcgggca ggcggagccg
    19441 cagccggacg gtgctgccgc ccggtccggt gcggatctgg acgatcgagc agagcagccg
    19501 caccgcccac agcccgaacc ggccgccggt cgcggtgccg gacgggcggg gcgggacgag
    19561 cccgcggccg gcgccggggt cccagcggcc ctcgtcggtg acctcgcaga cgagggccgg
    19621 gtcggcgccg gacgcctcgg tccacatccg cagcacgatc ggcggcgcgc cgtgccgcag
    19681 cgcgttcgtg acgacctcgg tgaccgcgac gagcagccgc tgcaggtcct cgtcgggcag
    19741 cggggtgcgg tgcgcgtact cggtgacgta ggcccgcagc cagtacaggt cggggcggac
    19801 gacgtcgagt tcgtcggcgt cggcgggcgg cgggggcagg ggttcgccgt cgcatttggc
    19861 gctgtaggcc cacgggtcca tgtagagggg gttggctacg gaccgcgcgc cgcgcaccgt
    19921 ctcggggtgg gtgcggcgcc cggccgcgac cacgccggcg ggcagcgacg aggagtaggg
    19981 gcacatgatg gccgcgccgg tgccgcggaa ggcgacgttc agcatcgcct cgacccgctg
    20041 ccactccagc acctccagcg gcggccgcga cgcccacacc accggctcgc cgaggaggcg
    20101 cagccgccgg ccgcgccagg cggtgtcgtc ggcgtcgctc aggcagtcgg cgagggtccg
    20161 cgcggggtgg gagtaccagg ccgccggctc gacgaactcg acggacgcgg cctcggcgcc
    20221 gagggcgtcg cgcagcagca tctcgcgggc gatcccgcag agggcgacga cgcggtcgcc
    20281 ggcctcggcg ccctcccgca ggaacggcag ggccccgtcg agcaggtcgt cgaccctgtc
    20341 gtacggcagg acgcaatggg tgaaggattc gctcacggcg gccccaggtc gcgtcttcga
    20401 tgccggcgtt ctcggcctgc cgcggcgccg gcagaccaaa caagggtagg tcgccttccc
    20461 ctccgcgcgc cgatccgttc actaattacc ccgacgggtt tttcacatag tgcgacgaga
    20521 tgccgggtga gtgcgggcgc cggggcggac gccgccgtcc gggcgggtgc ggcggtccgg
    20581 gcgggcgcgg cggtagagga cggcgcgcat gcccggggcg agcacggcga ttaattcatc
    20641 ggccgtcatc gacgccagcg gttccacggc caggacgtag cggccgaaga tgacgccggc
    20701 gagctgggcg ccgcacgcgg cggcgcggtg ccgggcgtcg ggcccgccga tgtgctcggc
    20761 gatgcggtcg atcatctcgc ggccgacgac gtcgcgcagc agccgggtga gctcggcgtc
    20821 ctgcgtcgcg gcgcgcacca tcaggatcag cgggcggccg cgctcggggt cgtcccaggt
    20881 cgccagcatc gcggccagga tgcgttcggg cagcgtggcg gggtcgccgg ggagcgcggc
    20941 ggccagcacg tccggggggt tggccatcag cccgaggacc gcgccgaaca ggcccttctt
    21001 cgagccgaag aagtagctga tgagcgcggc gtccacgtcg gcctcggcgg cgatggagcg
    21061 cagcgtcacc ttggcgtacc cgtcggcgag gaagcgggtg cgcgcgacgt cgaggatctg
    21121 cgcgcgggtg tcggggctgc cgcgccgccg cccgcgcgac gcccgcccgg cggccgggtc
    21181 cggcctccca gatttattca tcatggttga aatgtagtgc gccgggagcc agattcgaag
    21241 tgtcaccgcg aagagatccc gtcacctgga ggctccgatg gccaccaccg gaacggcgcc
    21301 cggagggcag gtccaccggg ccgtgctgcc ggccgtcatg ctcgccctcg ccaccgtcgt
    21361 gtcggcggtc gcgtccctca acaccgcgat cccgtcgatc gcccgcgaca cccgcgccac
    21421 gcagacccag ctgtcctgga tcatcgacgc gtacgcgctg gtgttcgcgg cgctgctgct
    21481 gctcggcggc gcgatcggcg accgctacgg gcggcgccgc gcgctcgccg ccgggctcgt
    21541 ggtcttcggc gccggctcgg tcgcggcgat gttcgccagc gaccccggct ggctgatcgc
    21601 gatgcgcggc gtcctcggcg tcggcgcggc gctggtcatg cccgcgacgc tgtccacgat
    21661 cacctcgacg ttcccggcgc ggcagcggac ccgcgccgtc ggcgcctggg ccggcgtcgc
    21721 cggcgccagc gcgatcctcg gcctgctggt gtcgggcagc ctgctggagc agt
//
