LOCUS       NZ_CP053892            46528 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6361910
            Orig. end                         :: 6408438
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..46528
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="T1PKS"
                     /region_number="18"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..46528
                     /SMILES="C([*])C(-O)"
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..46528
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="False"
                     /core_location="[20000:26528](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..26528
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     gene            complement(452..1624)
                     /locus_tag="ACTIVE_RS28285"
                     /old_locus_tag="ACTIVE_5664"
     CDS             complement(452..1624)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="ACTIVE_RS28285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5664"
                     /product="sensor histidine kinase"
                     /protein_id="WP_173097891.1"
                     /transl_table=11
                     /translation="MTMRFLDSGGIADADPGKARRRRAFWSSTGLIYLLPVTIDIAGYS
                     GARMALAIAGLIAFAALFLATPLSLRSWLEPVRTRTYVLLAAFAVLSAALPFAFGPAWL
                     GTSIYLSMVFAMTLPMNRVLWGVGGSMALAAVQCPLLGVPGALWPIALTTLSLGLFMVA
                     FRHARTLVQQLRIARGEVARLAAADERLRIARDLHDLLGHSLSLIVLKAELARRLGERD
                     AARAMAEVTDIESVARRSLADVRAAISGYRQRDLTEELDGARAVLSAAEVEVAVRTSGA
                     PLPDQVDGLFGWAVREGVTNIVRHARARRVTITVARERGEATLEIVDDGRGEVSEGHLP
                     GHGLEGLAERVADAAGTVAAGPREGGGFRLAVRVPLAPAGAERPAVESAM"
     misc_feature    1609..1623
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.7"
                     /tool="antismash"
     misc_feature    1819..1836
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.88"
                     /tool="antismash"
     gene            1901..3004
                     /locus_tag="ACTIVE_RS28290"
                     /old_locus_tag="ACTIVE_5665"
     CDS             1901..3004
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AurF"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654048.1"
                     /locus_tag="ACTIVE_RS28290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5665"
                     /product="ferritin-like domain-containing protein"
                     /protein_id="WP_173097892.1"
                     /sec_met_domain="AurF (E-value: 3.1e-15, bitscore: 55.2,
                     seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSYDLYTTPVPTETWNVPMSGEARFTWEYDEGRDRLLSLYQKGK
                     DKQWDATKRIDWDLEVDPVNVAGLPDNFNPLIGSDIWDKMSQKERDEFGRHQGSWLFSQ
                     FLHGEQGALNVSARIVQSVPDLDSKFYAATQTMDEARHVELYTKFLHEKIGMYYPINQD
                     LAKLLAESLEDSRWDLPYLGMQVLIEGLALAAFGLYRDMSTNPLVKQLLAYVMQDEARH
                     VAFGRLALKDYYAELTEKERAEREEFVVEGCYLMRDRFKGREVFEQMNMPVDKCMEYVD
                     NSDMYTLYQSLLFSRIVPCVRDVGLWGDKVKAAYADMGVLDNAKADLEALMRQDEEIAE
                     KVDEEKYAAELAARKTEVDDAIALGAE"
     misc_feature    complement(3183..3197)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.83"
                     /tool="antismash"
     misc_feature    3184..3195
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    complement(3239..3254)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     gene            3250..3552
                     /locus_tag="ACTIVE_RS28295"
                     /old_locus_tag="ACTIVE_5666"
     CDS             3250..3552
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_5666"
                     /product="hypothetical protein"
                     /protein_id="WP_173097893.1"
                     /transl_table=11
                     /translation="MNRSARKLLGLSAAAPLAAALTLAAAPAYAVQGPAADLVYGTVGQ
                     VGPALPPAPVPAPVSDAASRTAEAATGTADGALAAAPRPGGAGLAPRLPPSLLQL"
     misc_feature    complement(3571..3587)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.09"
                     /tool="antismash"
     assembly_gap    3597..3621
                     /estimated_length=25
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <3622..4361
                     /locus_tag="ACTIVE_RS28300"
                     /old_locus_tag="ACTIVE_5667"
     CDS             <3626..4361
                     /codon_start=3
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_5667"
                     /product="hypothetical protein"
                     /protein_id="WP_216857980.1"
                     /transl_table=11
                     /translation="LAPRLPVSRTAPAARTASAGPAARACRLDATKTVDGTRVTRLLPS
                     RTMALTPGRDGAPISAPRSGNCLGAADRTASGPGLGSGLPAPVGEAAKVPGRVVGRVTS
                     VPKRVVGSKVGKMGGGAVALPNARSGASGGGPLGDAVDLGLPGDASSLRSAAPISMVFP
                     DGVGARRSRPAPQNLVGEANDTVNQMHSQVGSVVNVLKTRERPSDTGRAGDGGLAGGGL
                     PGQGLADGLSGPPVYLPKLPAVR"
     misc_feature    complement(4432..4445)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.6"
                     /tool="antismash"
     misc_feature    complement(4441..4454)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.63"
                     /tool="antismash"
     misc_feature    complement(4445..4458)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            4459..4704
                     /locus_tag="ACTIVE_RS28305"
     CDS             4459..4704
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_173097894.1"
                     /transl_table=11
                     /translation="MSEITPSMASKLDLEMRSPSEVDQLHRAKREVTNPTKTGPALDSL
                     RAQRTVKDLCGAFEIKSEDATQPHLPDAEAAMTRTR"
     misc_feature    complement(4492..4505)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.94"
                     /tool="antismash"
     gene            4845..5492
                     /locus_tag="ACTIVE_RS48285"
                     /old_locus_tag="ACTIVE_5668"
     CDS             4845..5492
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017543368.1"
                     /locus_tag="ACTIVE_RS48285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5668"
                     /product="septal ring lytic transglycosylase RlpA family
                     protein"
                     /protein_id="WP_281382653.1"
                     /transl_table=11
                     /translation="MGNPDERPRLHARLQARLPRPRTRTLLIFSGVAAAVLAVGAFAIV
                     NGGKAPADSAQAAQTAPQATTPVADPPRPEPSRASRGEPRDPDPKHKKKAAPTKKARPA
                     ATAEHKAKPQKKTRVLQSGSCEASFYGEGQMTASGEPFDPGALTAAHKTLPMGSKVRVI
                     NKNNGKSVVVRINDRGPYAGGRCLDLSTAAMKKVGGTGSGVIPVRYEVLSKG"
     gene            complement(5569..>6174)
                     /locus_tag="ACTIVE_RS46845"
                     /old_locus_tag="ACTIVE_5669"
                     /pseudo=""
     CDS             complement(5569..>6174)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654046.1"
                     /locus_tag="ACTIVE_RS46845"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5669"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LLALARGEVAVSAAAAVAPVVAPARAARAVERRAGRDRAWSGPAQ
                     ELADRLDLGALAGDIAARDVPLLLVGGGRDRVVPAGEVTAFRDVLQRRGAGAVETATFR
                     MGHALAAEPGTEPRPPITDAVRVDGLLTDWFRERLADVRAEPDQDAVPADAVPADAVPA
                     DAVPGDSAHADPESVDAEPVDTTAVDTAPYPAPARAAR"
     assembly_gap    6175..6199
                     /estimated_length=25
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<6200..6623)
                     /locus_tag="ACTIVE_RS46850"
                     /old_locus_tag="ACTIVE_5670"
                     /pseudo=""
     CDS             complement(<6200..6623)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631823.1"
                     /locus_tag="ACTIVE_RS46850"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5670"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSGDHVNRPVHGTAGGAAYVALPPTAVDATASGPTLLMIAWPGFD
                     PPRTAAALAAAVPMTGVPVWRAYLDLPGRSPGGLGSGAILETEAIEAYGRAVEQAAAGL
                     PAAVAELRRDLALPDGPVALAGFSAGGAAALLALARG"
     misc_feature    6724..6742
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.16"
                     /tool="antismash"
     misc_feature    complement(6727..6742)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.0"
                     /tool="antismash"
     gene            6932..7294
                     /locus_tag="ACTIVE_RS28320"
                     /old_locus_tag="ACTIVE_5671"
     CDS             6932..7294
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631824.1"
                     /locus_tag="ACTIVE_RS28320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5671"
                     /product="YkvA family protein"
                     /protein_id="WP_173097895.1"
                     /transl_table=11
                     /translation="MDRNRRTAAAGQAWQIYSETLQPDVPGFWERFRAVPRMLKAVLRG
                     RYKGMSFGTLGLLALGLVYIISPIDAIPDVIPIAGIADDTGLALWLAAVLVKSAGDFVM
                     WERSGRPTVIVGEPID"
     gene            complement(7334..8077)
                     /locus_tag="ACTIVE_RS28325"
                     /old_locus_tag="ACTIVE_5672"
     CDS             complement(7334..8077)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654044.1"
                     /locus_tag="ACTIVE_RS28325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5672"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_281382654.1"
                     /transl_table=11
                     /translation="MAEAVRSLERAFELLEHLADAGGEMALSELTEVSGLPMPTIYRLM
                     RTLVNHGYVRQEPSKRYALGPRLIRLGEGANRLLGTWARPVLGRLVDDVGETANMAVLE
                     GDEAVYVAQVPSKHSMRMFTEVGRRVQPHCTGVGKALLSQLPDERVREILGRTGMAAHT
                     PNTFTDQDALLAELHRIREQGYALDDEEQEIGVRCVAVPLQGAPALTALSVSGPSARMT
                     HDAVADVVPIVRDAASRFAKELGGA"
     gene            8275..10044
                     /locus_tag="ACTIVE_RS28330"
                     /old_locus_tag="ACTIVE_5673"
     CDS             8275..10044
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_5673"
                     /product="hypothetical protein"
                     /protein_id="WP_173097896.1"
                     /transl_table=11
                     /translation="MRTGGSRTRSRARVGAIMAGGALAVPPMMMLGGAAANANPSAVRL
                     LAETSTSAGAVAGPGYALGHTVRVHAEGGTAHHAVLRMLAADPLTWANRPAGCARLDSG
                     RELRCDLGDVGGATVTRTGTVAVPASAVPRRAPGSRPAILTVAAADNAAPTTSRAVLDF
                     SPGGESGSATADDPPAQPQPAPNEGDAHCSADAKPCQDAVPEGQAPPQQSAQQSAPQKG
                     DPQCRGIADADRPKGALPASPCHNTPSPAGTAPAGQAEPAHEGRPAHNGRPPHHNRPPD
                     EPRPALQPAPAKPRHHGHPSAQGQPAHPRPIKPFTHGQPHPGKPSTPPFTDEQPPAPHG
                     NKLPHHSAPSRPAAPKHPASSQHSTSPQAGEPTQHNVTIYGDAPAGAAGGSTAHGHHTW
                     SYGDQAQSETGVPWGAPGAGKHKHHAGASAGSVPSTEDEYPADGYPADAYPAGADGGAG
                     YGGSAGGGHVKPGQVPELPAGPAPARPGVALPPLTAPGAMPAPNSQAMAGTTSDGTDHG
                     DGRMTLVSPVGMEQGNGTDWAVVLGVAIVAEIGLLWGAACFGLWRRRIALYRAETRAAE
                     ARAEAAAQGGAYI"
     gene            10226..10474
                     /locus_tag="ACTIVE_RS28335"
                     /old_locus_tag="ACTIVE_5674"
     CDS             10226..10474
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852083.1"
                     /locus_tag="ACTIVE_RS28335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5674"
                     /product="zf-TFIIB domain-containing protein"
                     /protein_id="WP_173097897.1"
                     /transl_table=11
                     /translation="MSEATMQCPKCESKLDTHERHGVVIEECPGCKGVFLDRGELEQLI
                     DAESRYLAELPEAENPDTTYQGRHRRGIMQQIFAADR"
     misc_feature    complement(10512..10526)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.79"
                     /tool="antismash"
     gene            10730..12526
                     /locus_tag="ACTIVE_RS28340"
                     /old_locus_tag="ACTIVE_5675"
     CDS             10730..12526
                     /NRPS_PKS="Domain: CAL_domain (53-502). E-value: 2.3e-97.
                     Score: 318.1. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS28340_CAL_domain.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FAAL_cd05931"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631827.1"
                     /locus_tag="ACTIVE_RS28340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5675"
                     /product="fatty acyl-AMP ligase"
                     /protein_id="WP_173097898.1"
                     /sec_met_domain="FAAL_cd05931 (E-value: 3e-212, bitscore:
                     706.6, seeds: 56, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.3e-75, bitscore:
                     252.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALGSLLPELLPGGSGRTPLIERVARWAREKPDAPAFTFVDYSLD
                     PAGRHLTLSWAETDRRARATATALRQVTGPGERAALLLPQTLEYMMTMLGAMYAHVIAV
                     PLFSPDLPGHADRLIGAYTDSEPAVIVTTRNALPHVEKFLADHDVPQPKEILFAEEVDL
                     GLADSWEDEPIGFDDLAYLQYTSGSTRRPAGVEITHGNVTANAAQLWSGWAPDKPDPEL
                     VSWLPLFHDMGLIATMALPLVRGDHAIYTDPVSFIMNPMRWLQLIAGRPGKNVYTAGPN
                     FAYEYVASMASPEKLAGLDLSGLTTCLNGAEPIRTSTLSTFAEALAPAGLRPGAQAPGY
                     GLAEATVFVTAAAEDVPPKIISVDREALTQGEVRLCAADAERASTLVSCGRPSGQLVAI
                     VDPDASTEQPDGRVGEIWVHGPNTAAGYWRNSERSQDTFGGELAEPGELPAGPWMKTGD
                     YGVVHEGELYVTGRIKDLIIVDGRNHYPQDIEVTAQEAHPAVRPDHVAAFALPGEETER
                     LVVVAERNRRVPLGRLDLDEVEAAVRGAVNVEHEMSVHAFLLVEPGAVSRTSSGKIARA
                     ATRQRYLDGALPTTAARLASRK"
     aSDomain        10889..12235
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS28340_CAL_domain.1"
                     /evalue="2.30E-97"
                     /label="ACTIVE_RS28340_CAL_domain.1"
                     /locus_tag="ACTIVE_RS28340"
                     /protein_end="502"
                     /protein_start="53"
                     /score="318.1"
                     /specificity="Minowa: NH2"
                     /tool="antismash"
                     /translation="SWAETDRRARATATALRQVTGPGERAALLLPQTLEYMMTMLGAMY
                     AHVIAVPLFSPDLPGHADRLIGAYTDSEPAVIVTTRNALPHVEKFLADHDVPQPKEILF
                     AEEVDLGLADSWEDEPIGFDDLAYLQYTSGSTRRPAGVEITHGNVTANAAQLWSGWAPD
                     KPDPELVSWLPLFHDMGLIATMALPLVRGDHAIYTDPVSFIMNPMRWLQLIAGRPGKNV
                     YTAGPNFAYEYVASMASPEKLAGLDLSGLTTCLNGAEPIRTSTLSTFAEALAPAGLRPG
                     AQAPGYGLAEATVFVTAAAEDVPPKIISVDREALTQGEVRLCAADAERASTLVSCGRPS
                     GQLVAIVDPDASTEQPDGRVGEIWVHGPNTAAGYWRNSERSQDTFGGELAEPGELPAGP
                     WMKTGDYGVVHEGELYVTGRIKDLIIVDGRNHYPQDIEVTAQEAHPAVRP"
     CDS_motif       11267..11326
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS28340_0001"
                     /evalue="5.70E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ACTIVE_RS28340"
                     /protein_end="199"
                     /protein_start="179"
                     /score="22.0"
                     /tool="antismash"
                     /translation="AYLQYTSGSTRRPAGVEITH"
     CDS_motif       11954..12043
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS28340_0002"
                     /evalue="4.40E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="ACTIVE_RS28340"
                     /protein_end="438"
                     /protein_start="408"
                     /score="28.6"
                     /tool="antismash"
                     /translation="PDGRVGEIWVHGPNTAAGYWRNSERSQDTF"
     CDS_motif       12137..12199
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS28340_0003"
                     /evalue="2.10E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="ACTIVE_RS28340"
                     /protein_end="490"
                     /protein_start="469"
                     /score="14.0"
                     /tool="antismash"
                     /translation="TGRIKDLIIVDGRNHYPQDIE"
     gene            12640..15348
                     /locus_tag="ACTIVE_RS28345"
                     /old_locus_tag="ACTIVE_5676"
     CDS             12640..15348
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654042.1"
                     /locus_tag="ACTIVE_RS28345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5676"
                     /product="MMPL family transporter"
                     /protein_id="WP_173097899.1"
                     /transl_table=11
                     /translation="MLSGLGRLIHRRRWISLVCILLLTGVAGAWGLGVFAKFKAGGFED
                     PNASSTLVARLGATYFGSTNPDVLVLYKSDTMTVDDPRYEAAVVTTVARLPKDRVEELI
                     SYWALDEKDAVSFASRDKHETFVALKLKGDDPTKLKNYQDIKERLKAPGLTVQFGGAVP
                     LGQEFGEQVTADIVRAELITALPLLTLLVLLFGAVVAASLPLFVALFSMIGGLAVLHIV
                     TYAADVTSFALEVVTMMGVGLAIDYSLFIISRFREELQRGMAAQGVPPGKPWKRERDKQ
                     ARKAAKKAHREAMRPLREDALAATLATAGRTIMVSGVTVSAALAGLLLFPQMFLRTIGL
                     AGIATVMVAVFGATVLLPTLLALLGPRVEGGRMPWRRPTSKRAQRDHDSGFWYRLGHSV
                     MKHPLPYFAVVLVILGVMFGPFLHVQFGSIDARVLPKDSATRAVVENVKADFPNGTAEP
                     IDVVISGDLIPRDWKPSKSSDNIPPYLEGFRKKLAALPGVTEAKFTGYSGAYGGVRISV
                     THKYEPMDEHAQDLVKRIRAMSLEKDGYPMHIDVGGSTAAQMDLMSSLMRSLPKMAVAV
                     GVATFILLFMFFGSIVLPLKAIVMNVLSIGASFGAIVWGFQYGHLAGILNFTPTGGVEA
                     TSMILILAVVFGLSMDYEVFLLSRIREEWDRTHDNRAAVARGMQHTGGIITSAALLFLV
                     VIGAFSMAGITVVKLIGVGMFVAVVVDAALVRSLLVPATMRFMGKANWWLPAPLAFLHA
                     KMDLREHSVAGAGAGPAAVAVPPPLPEAQPFPYRMHWEQGSAETPAPPAAPAAPPPPAP
                     PAPPAAPLNVHDAFKPAMQPAGERPQLVFRDPSPATAARPAQAQTPAPQPQAPWAPWAN
                     GRPQPRPVRPPRVKRRIVPSPDGSGWTWSSD"
     gene            complement(15352..16584)
                     /locus_tag="ACTIVE_RS28350"
                     /old_locus_tag="ACTIVE_5677"
     CDS             complement(15352..16584)
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1102: glycosyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012855060.1"
                     /locus_tag="ACTIVE_RS28350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5677"
                     /product="glycosyltransferase"
                     /protein_id="WP_173097900.1"
                     /sec_met_domain="MGT (E-value: 4.2e-33, bitscore: 114.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRIVIFAAGSRGDIQPCVALGRALRERGDEVRLVASARYAPMAV
                     AAGLELAALTADPTEILESDAGQELLAGGRNPVKFLGGFRRILGPMAERLLGECLDACK
                     GADLILGPTLGFLPEHIGEHLGVPRALIHFQPSRPTGAFPHPFVPQARMFGPWANRASF
                     GAVDQIAWQLSRPFINPWRDERLGLPRLPLRGLRRDGTTVLACFSEAVVPRPKDWPASV
                     HMTGYWFLDEPEWDPPEEIAAFMAAGPPPVYVGFGSMVPKDAEMTGRIVRAALRLAGVR
                     GVVQGDPATSDDEVLAVRDVPHSWLFPRMSAVVHHGGAGTTAAGLRFGVPTVVCPFFGD
                     QPYWGERVAALGAGPAPLPFRAMTVPRLARELRRVAEDQEMADRAYEVGRRIRAEDGVG
                     RAREIIAGLLR"
     gene            complement(16594..19710)
                     /locus_tag="ACTIVE_RS47635"
                     /old_locus_tag="ACTIVE_5678"
     CDS             complement(16594..19710)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0009410 - response to xenobiotic stimulus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="ACTIVE_RS47635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5678"
                     /product="MDR family MFS transporter"
                     /protein_id="WP_246342242.1"
                     /transl_table=11
                     /translation="MTRGRYRWALAVVAVSAFMTTMDNTVVFTALPRIMADLGMSSSAK
                     DWVATGYILMFSCLMITGGRLTDIYGCRVTFTTGMTVFTAASAVCGLAHGSEILILARI
                     VQGGGAALVLPATQVMVTVGRNDKQRSIGNIVFIGAASSATALGPTIGGIIVEHFHWGW
                     IFLINIVPGILVILLGAVVLTGRGKNRRARIDLPGVLISATMLFAFIYGLEDGNKHGWT
                     DPSVLSTFALGAIALVCFIVVESWAPEPMIDLRFFRNRVFTGGLVSQMLYGIGFNGMMF
                     YSQPFLQRFLGFSPPEAGLVMLPPALTIMVLTPVAFLLATKLGPRPAIGAGMALMGVGM
                     LLFSTLQIGDGYADLMPGVLLVGVGAALAMPLVMYVLKAVPEKRAGVASGVINVIREAS
                     GAFGIAIVGLLVHTIPDESASTKALESFRQGTSSGLALGAGLVLIGGVISALTLPSRRG
                     WLGPKHGKQAPLIAEPAAAPAPALATAAAAVTATPRDPLPVVPAPDPAGAAPSAEPVPA
                     PLPFRTETETMAAPRTPGPHWWSDTPDDDAPATWRPTPPDATSPWQDWADTAIPTWTTP
                     DDEPSPPTSKWFDDESAARSRGTLPLSGDPLATLPDRWTPGGTSPAPGSEPIADAVLKD
                     LASRGKNLPKPKPSPPAATHQPGTGSPEPQEAPEAADLDDPARPGEDQPIGQAEHTALP
                     APVPGTPHPSAEPPETPTPQSESTTPPTQSHNDERPATTATQDEPNHASDQHTGTPYPA
                     SEAPHSTTSPPPETAAPQSEAPSTTPPSQPLNDERPATAAQGEPGHAGDQHVGAPYPAH
                     GAAPPPPVTLKLGGTDPLGATAVNGLEDAEEAPPALGDRPLDEQLDGGAGGATTPVAAM
                     HETVTPDTAGPMAGTPSAAAPDAATPEAAVPDAMAPEAGTPDTATPAAATPVAITPVAG
                     APGAGGSGLGGVAGGGAESEAAGLREGEAREEPAADDRPRGVSGGEPGDAWVAGRGGAE
                     AGPDDDEVPEVGGPGWPPPPPDGWMYAPYVPEDEDPAGGPDVRPRSDAW"
     misc_feature    19777..19790
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.96"
                     /tool="antismash"
     misc_feature    complement(19872..19892)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.15"
                     /tool="antismash"
     gene            20001..26528
                     /locus_tag="ACTIVE_RS48290"
                     /old_locus_tag="ACTIVE_5679"
     CDS             20001..26528
                     /NRPS_PKS="Domain: ACP (27-95). E-value: 1.5e-17. Score:
                     55.7. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS48290_ACP.1"
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (120-548). E-value:
                     1.8e-178. Score: 585.7. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS48290_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (649-948). E-value: 7.3e-80.
                     Score: 260.4. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS48290_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (1010-1153). E-value: 8.9e-25.
                     Score: 79.9. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS48290_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (1430-1608). E-value: 9.7e-50.
                     Score: 161.0. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS48290_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (1690-1768). E-value: 3.5e-15.
                     Score: 48.1. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS48290_PKS_PP.1"
                     /NRPS_PKS="Domain: PCP (1803-1869). E-value: 1.6e-12.
                     Score: 39.4. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS48290_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1888-2009). E-value:
                     8.9e-26. Score: 83.6. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS48290_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012855058.1"
                     /locus_tag="ACTIVE_RS48290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5679"
                     /product="type I polyketide synthase"
                     /protein_id="WP_173097901.1"
                     /sec_met_domain="hyb_KS (E-value: 2.5e-179, bitscore:
                     595.7, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.6e-89, bitscore:
                     298.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.1e-77, bitscore: 260.4,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.4e-42, bitscore:
                     144.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.6e-09, bitscore:
                     37.2, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 2.5e-21, bitscore:
                     76.0, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQSNDRSGAARDNAEGEPRIGEDAIRRHLVEQIARRSRIAEAEVD
                     PDRPLEEFGLASRDAVAIAGDLEQMLGRALPATLVWEHPTISKLSRALAGGAGAAEAEA
                     ERAAAPVRAVVREDEPIAVVGIGCRFPGGDRDLTGPAEYWRFLTGRGDAIREVPDGRWD
                     PFDDGSPEVADRLARTTRLGGFLDDVAEFDAQFFGITPREAAVMDPQQRLVLEVAWEAF
                     EHAGIGPASLRGSRTGVFVGVSAPEYAAFTASDLASLEPFTATGAALSIIANRLSYLLD
                     LRGPSMIVDTACSSSLVSTHLAVQALRSGEADVALAGGVNVLLSPTVTMTFDLADATAK
                     DGHCKAFDASADGMVRAEGCGAVVLKRLSDAVRDGDRVLAVVKGSGVNSDGRSNGLVAP
                     NSDAQRALLRDVYAAAGVETGEVDYIEAHGTGTFLGDPIEAKAVGEVLGAGRAEDEPLL
                     IGSAKSNLGHMESAAGIAGLIKTVLALHHKVIPASAHYKEPNPHIPFDELRLKVVADET
                     PWPERSHPARAGVSGFGFGGTNAHVLLEEAPAQEFASQPAVIRTFPLSDTADDRVRDHA
                     ALLAAWAADRDDVKLADVARTLHRRGGRGRARAAVSARDRAGLVEGLKALAEGRPHPGV
                     VTGSALGVPGRPVWVFSGYGAQRAGMAQRLLEEEPAFAEAIDDLDGLFAEEGGPDLWSL
                     LEEGRKPDGPADTMPVLFAIQLGLARMWKAYGVVPGAVIGHSMGEVAAAVVAGALTPQD
                     GVRVIVRRSRLLTQLVGGGAMAVLGASAQEVERLADGLPEVYAAVHSSPKQTVVTGDAD
                     QVAEIVKRAEAEGRLARMIQAEGAGHSPQVDPLLPDLREQLAEVGLEPGTPLADGIRLY
                     TTALPDPRAFDGDGARLDVEYWAANLRNPVRLTDAVSAAAEDGFRTFVEINAHPILAHA
                     VGETLGGSGALVTHTLKRAPKGQETDDTLTFHAQLATLAAHGLAVAQPVDGRIVDVPQS
                     PWRHERHWVDLSSRNRGGRDEHPLLGAHVELPGEDRHAWRADVGLDAQPWLNDLTVHGL
                     HALPVAAFAEMALAAGAEALGTDAVRVNSLWIERPLALAEHTTVTTTFAEAEQRVEVHA
                     QTPAGTWARLASADVGEDTRPAPAPEPGAATEVAGAERGSRHYRLHPEVFDRCLAALSA
                     EAAAVAGGGVWLAETIGSLRVHGPAHRGGHVRAAVAEDGGELTGSVLLLDADGGVLVEA
                     SGIVLRRTERHDVPVPVADKLVELVWDEADASEPGDGDGTWLILAEDGDALAAATAAGL
                     GERGRRVTRRGFAEVGDASGAEGVVLVPSADLVDEDLVLAIADVSRSLPDGPRLYIATH
                     RAVPVLDGEAGEPGHGFAAALTRVLAFERTVQRATLVDVDRPTDLVAELLGGDGAREVA
                     RRGGRRYVARLAQAALPEAKAKRIVRRGGAYIITGGYGGIGLVTARLLAERGAGRIVLS
                     GRSGPGADAEKVIAKLREGGVDVGVVLGDIAAPGTAERLVKVAQEGGVRLCGVVHGAGA
                     IDDRLIADLGAEDLHRVWTAKVEGARRLSDATWDLGLDWFAVHSSAAALLGSPGQAAYA
                     AANAAIDALTAYRRAHGRPGTTINWGTWSRVGGAAETAVTVIDPISPEEGAEALEALLA
                     HGMTATGVLRFDPVTAVELFPEIRNMPYFAALTEAAAERGADDAGDWPGVDALKELDPA
                     EARTLIAAQIRYRIASVLGFDPERLDPAVPLTDLGLDSLVAVRIKSGVEHDLGLTVPPA
                     VLLQGASVNVFEEWASGELGLADAAAPTAVSNAESGYVMPRDAAERLAVRIFEDVLGLD
                     RVGVTADFFADLGGREHQADQVVAMVAAELGGEVTRGELFAVPTAENVAEVLRAADEEA
                     ARQTVRPLKPSGDRRPIFIAHPAGGTTACYRQLIDLLGDDQPVYGLERFEDAPPVEERA
                     ARYVQHLLEAQPEGAFRLGGWSFGGVLAYETARQLRAAGREVEFVALFDAGIPLPVDDE
                     SDTLARRFSAFADYINETYGLDVTLTYDELSGLDEEAQFALVMERAAPLVDYIPPAALT
                     HQLTSHQDTRSLEAYQPGTYDGRVVLYYAPEETPWAVRDARYVLDGTNGFGGLCSDLEI
                     VTIPGVHHLNLLDPPGVEILAAHLEGRLAGRAPAADGANRRPADGPDARDASGRARAAA
                     RSTMAR"
     aSDomain        20082..20285
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS48290_ACP.1"
                     /evalue="1.50E-17"
                     /label="ACTIVE_RS48290_ACP.1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="95"
                     /protein_start="27"
                     /score="55.7"
                     /tool="antismash"
                     /translation="HLVEQIARRSRIAEAEVDPDRPLEEFGLASRDAVAIAGDLEQMLG
                     RALPATLVWEHPTISKLSRALAG"
     aSDomain        20361..21644
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS48290_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="1.80E-178"
                     /label="ACTIVE_RS48290_PKS_KS.1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="548"
                     /protein_start="120"
                     /score="585.7"
                     /tool="antismash"
                     /translation="IAVVGIGCRFPGGDRDLTGPAEYWRFLTGRGDAIREVPDGRWDPF
                     DDGSPEVADRLARTTRLGGFLDDVAEFDAQFFGITPREAAVMDPQQRLVLEVAWEAFEH
                     AGIGPASLRGSRTGVFVGVSAPEYAAFTASDLASLEPFTATGAALSIIANRLSYLLDLR
                     GPSMIVDTACSSSLVSTHLAVQALRSGEADVALAGGVNVLLSPTVTMTFDLADATAKDG
                     HCKAFDASADGMVRAEGCGAVVLKRLSDAVRDGDRVLAVVKGSGVNSDGRSNGLVAPNS
                     DAQRALLRDVYAAAGVETGEVDYIEAHGTGTFLGDPIEAKAVGEVLGAGRAEDEPLLIG
                     SAKSNLGHMESAAGIAGLIKTVLALHHKVIPASAHYKEPNPHIPFDELRLKVVADETPW
                     PERSHPARAGVSGFGFGGTNAHVLLEEAP"
     aSModule        20361..25304
                     /complete
                     /domains="nrpspksdomains_ACTIVE_RS48290_PKS_KS.1"
                     /domains="nrpspksdomains_ACTIVE_RS48290_PKS_AT.1"
                     /domains="nrpspksdomains_ACTIVE_RS48290_PKS_DH.1"
                     /domains="nrpspksdomains_ACTIVE_RS48290_PKS_KR.1"
                     /domains="nrpspksdomains_ACTIVE_RS48290_PKS_PP.1"
                     /locus_tags="ACTIVE_RS48290"
                     /monomer_pairings="pk -> pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       20850..20897
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0001"
                     /evalue="2.70E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="299"
                     /protein_start="283"
                     /score="19.3"
                     /tool="antismash"
                     /translation="GPSMIVDTACSSSLVS"
     CDS_motif       21039..21077
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0002"
                     /evalue="1.10E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="359"
                     /protein_start="346"
                     /score="12.2"
                     /tool="antismash"
                     /translation="FDASADGMVRAEG"
     CDS_motif       21270..21317
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0003"
                     /evalue="7.20E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="439"
                     /protein_start="423"
                     /score="11.9"
                     /tool="antismash"
                     /translation="YIEAHGTGTFLGDPIE"
     CDS_motif       21378..21422
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0004"
                     /evalue="6.10E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="474"
                     /protein_start="459"
                     /score="9.5"
                     /tool="antismash"
                     /translation="GSAKSNLGHMESAAG"
     CDS_motif       21942..21998
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0005"
                     /evalue="1.60E-04"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="666"
                     /protein_start="647"
                     /score="14.3"
                     /tool="antismash"
                     /translation="VWVFSGYGAQRAGMAQRLL"
     aSDomain        21948..22844
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS48290_PKS_AT.1"
                     /evalue="7.30E-80"
                     /label="ACTIVE_RS48290_PKS_AT.1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="948"
                     /protein_start="649"
                     /score="260.4"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFSGYGAQRAGMAQRLLEEEPAFAEAIDDLDGLFAEEGGPDLWSL
                     LEEGRKPDGPADTMPVLFAIQLGLARMWKAYGVVPGAVIGHSMGEVAAAVVAGALTPQD
                     GVRVIVRRSRLLTQLVGGGAMAVLGASAQEVERLADGLPEVYAAVHSSPKQTVVTGDAD
                     QVAEIVKRAEAEGRLARMIQAEGAGHSPQVDPLLPDLREQLAEVGLEPGTPLADGIRLY
                     TTALPDPRAFDGDGARLDVEYWAANLRNPVRLTDAVSAAAEDGFRTFVEINAHPILAHA
                     VGETLGGSGALVTHTLKR"
     CDS_motif       22125..22172
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0006"
                     /evalue="1.30E-03"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="724"
                     /protein_start="708"
                     /score="12.1"
                     /tool="antismash"
                     /translation="PVLFAIQLGLARMWKA"
     CDS_motif       22176..22295
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0007"
                     /evalue="3.80E-17"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="765"
                     /protein_start="725"
                     /score="54.4"
                     /tool="antismash"
                     /translation="GVVPGAVIGHSMGEVAAAVVAGALTPQDGVRVIVRRSRLL"
     CDS_motif       22662..22709
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0008"
                     /evalue="8.50E-04"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="903"
                     /protein_start="887"
                     /score="11.9"
                     /tool="antismash"
                     /translation="LDVEYWAANLRNPVRL"
     aSDomain        23031..23459
                     /ASF="catalytic triad H,G,P found: False"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS48290_PKS_DH.1"
                     /evalue="8.90E-25"
                     /label="ACTIVE_RS48290_PKS_DH.1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="1153"
                     /protein_start="1010"
                     /score="79.9"
                     /tool="antismash"
                     /translation="HPLLGAHVELPGEDRHAWRADVGLDAQPWLNDLTVHGLHALPVAA
                     FAEMALAAGAEALGTDAVRVNSLWIERPLALAEHTTVTTTFAEAEQRVEVHAQTPAGTW
                     ARLASADVGEDTRPAPAPEPGAATEVAGAERGSRHYRLH"
     CDS_motif       23115..23192
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0009"
                     /evalue="5.40E-04"
                     /label="PKSI-DH_m2"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="1064"
                     /protein_start="1038"
                     /score="12.7"
                     /tool="antismash"
                     /translation="WLNDLTVHGLHALPVAAFAEMALAAG"
     aSDomain        24291..24824
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N found: True"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS48290_PKS_KR.1"
                     /evalue="9.70E-50"
                     /label="ACTIVE_RS48290_PKS_KR.1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="1608"
                     /protein_start="1430"
                     /score="161.0"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="GAYIITGGYGGIGLVTARLLAERGAGRIVLSGRSGPGADAEKVIA
                     KLREGGVDVGVVLGDIAAPGTAERLVKVAQEGGVRLCGVVHGAGAIDDRLIADLGAEDL
                     HRVWTAKVEGARRLSDATWDLGLDWFAVHSSAAALLGSPGQAAYAAANAAIDALTAYRR
                     AHGRPGTTINWGTWS"
     CDS_motif       24294..24392
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0010"
                     /evalue="8.00E-13"
                     /label="PKSI-KR_m1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="1464"
                     /protein_start="1431"
                     /score="40.9"
                     /tool="antismash"
                     /translation="AYIITGGYGGIGLVTARLLAERGAGRIVLSGRS"
     CDS_motif       24669..24779
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0011"
                     /evalue="1.70E-16"
                     /label="PKSI-KR_m4"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="1593"
                     /protein_start="1556"
                     /score="52.8"
                     /tool="antismash"
                     /translation="LDWFAVHSSAAALLGSPGQAAYAAANAAIDALTAYRR"
     aSDomain        25071..25304
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS48290_PKS_PP.1"
                     /evalue="3.50E-15"
                     /label="ACTIVE_RS48290_PKS_PP.1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="1768"
                     /protein_start="1690"
                     /score="48.1"
                     /tool="antismash"
                     /translation="LKELDPAEARTLIAAQIRYRIASVLGFDPERLDPAVPLTDLGLDS
                     LVAVRIKSGVEHDLGLTVPPAVLLQGASVNVFE"
     aSDomain        25410..25607
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS48290_PCP.1"
                     /evalue="1.60E-12"
                     /label="ACTIVE_RS48290_PCP.1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="1869"
                     /protein_start="1803"
                     /score="39.4"
                     /tool="antismash"
                     /translation="AVRIFEDVLGLDRVGVTADFFADLGGREHQADQVVAMVAAELGGE
                     VTRGELFAVPTAENVAEVLRA"
     aSModule        25410..26027
                     /domains="nrpspksdomains_ACTIVE_RS48290_PCP.1"
                     /domains="nrpspksdomains_ACTIVE_RS48290_Thioesterase.1"
                     /final_module
                     /incomplete
                     /locus_tags="ACTIVE_RS48290"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        25665..26027
                     /ASF="active site serine present: True"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS48290_Thioesterase.1"
                     /evalue="8.90E-26"
                     /label="ACTIVE_RS48290_Thioesterase.1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="2009"
                     /protein_start="1888"
                     /score="83.6"
                     /tool="antismash"
                     /translation="RPIFIAHPAGGTTACYRQLIDLLGDDQPVYGLERFEDAPPVEERA
                     ARYVQHLLEAQPEGAFRLGGWSFGGVLAYETARQLRAAGREVEFVALFDAGIPLPVDDE
                     SDTLARRFSAFADYINE"
     CDS_motif       25830..25904
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS48290_0012"
                     /evalue="2.60E-13"
                     /label="NRPS-te1"
                     /locus_tag="ACTIVE_RS48290"
                     /protein_end="1968"
                     /protein_start="1943"
                     /score="42.2"
                     /tool="antismash"
                     /translation="QPEGAFRLGGWSFGGVLAYETARQL"
     gene            26568..27887
                     /gene="ccrA"
                     /locus_tag="ACTIVE_RS28365"
                     /old_locus_tag="ACTIVE_5680"
     CDS             26568..27887
                     /EC_number="1.3.1.85"
                     /GO_function="GO:0043880 - crotonyl-CoA reductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (50-408). E-value: 3.4e-24.
                     Score: 77.5. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS28365_PKS_ER.1"
                     /codon_start=1
                     /gene="ccrA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018654035.1"
                     /locus_tag="ACTIVE_RS28365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5680"
                     /product="crotonyl-CoA carboxylase/reductase"
                     /protein_id="WP_173097902.1"
                     /sec_met_domain="ADH_N (E-value: 8.8e-07, bitscore: 27.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.6e-22, bitscore:
                     77.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANELLDAVRSGASGPELQDIDLPSRFRAAFTRKDEVGIFDGQAD
                     KDVRRSLHVGEVDMPELAPDECVVAVMAAAINFNTVWSAIFEPVPTFAFLEKFGRQGWY
                     GARHDLPYHILGSDGAGVVVRTGAGVKNWKVGDKVVLSPSYVDEEDHGSYDDGMMSESQ
                     LAWGFETNFGSLGEYCIVKANQLIKKPAHLTWEEAGSNTLCAGTAYRMLVGPHGARMKQ
                     GDVVLIWGATGGLGSFATQLVKNGGGIPVGVVSSEEKAEIVRAQGCEHVINRNELNLGE
                     QGLRHPKAGRMLGEAIRGLVGEDPGIVFEYLGRETFGASVYVAKRGGKIVTCGSSTGYK
                     HEYDNRFLWMRLKSIIGSHGFNYHEAVEVNRLFSLGMIHPTLSSVFPLDEAGEATRAVQ
                     TNQHIGKVAVLCGATGEGQGVDDPALRERIGEDKFNLYRR"
     aSDomain        26718..27791
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS28365_PKS_ER.1"
                     /evalue="3.40E-24"
                     /label="ACTIVE_RS28365_PKS_ER.1"
                     /locus_tag="ACTIVE_RS28365"
                     /protein_end="408"
                     /protein_start="50"
                     /score="77.5"
                     /tool="antismash"
                     /translation="SLHVGEVDMPELAPDECVVAVMAAAINFNTVWSAIFEPVPTFAFL
                     EKFGRQGWYGARHDLPYHILGSDGAGVVVRTGAGVKNWKVGDKVVLSPSYVDEEDHGSY
                     DDGMMSESQLAWGFETNFGSLGEYCIVKANQLIKKPAHLTWEEAGSNTLCAGTAYRMLV
                     GPHGARMKQGDVVLIWGATGGLGSFATQLVKNGGGIPVGVVSSEEKAEIVRAQGCEHVI
                     NRNELNLGEQGLRHPKAGRMLGEAIRGLVGEDPGIVFEYLGRETFGASVYVAKRGGKIV
                     TCGSSTGYKHEYDNRFLWMRLKSIIGSHGFNYHEAVEVNRLFSLGMIHPTLSSVFPLDE
                     AGEATRAVQTNQHIGKVA"
     CDS_motif       26910..26948
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS28365_0001"
                     /evalue="9.70E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="ACTIVE_RS28365"
                     /protein_end="127"
                     /protein_start="114"
                     /score="9.1"
                     /tool="antismash"
                     /translation="LGSDGAGVVVRTG"
     CDS_motif       27753..27794
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS28365_0002"
                     /evalue="5.50E-03"
                     /label="PKSI-ER_m9"
                     /locus_tag="ACTIVE_RS28365"
                     /protein_end="409"
                     /protein_start="395"
                     /score="10.1"
                     /tool="antismash"
                     /translation="RAVQTNQHIGKVAV"
     gene            27973..28932
                     /locus_tag="ACTIVE_RS28370"
                     /old_locus_tag="ACTIVE_5681"
     CDS             27973..28932
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_5681"
                     /product="hypothetical protein"
                     /protein_id="WP_173097903.1"
                     /transl_table=11
                     /translation="MTFRGGRRRGAREEAARFETRLTAFGELLAGHPFSADRLDATHEM
                     AVEYARALDAYEAAKRAASRDPALAGRELAAGLAALNRLNTHLVGTAAPEAPAKPKARR
                     PEPQVLEVEAEATPVEADHGDRRPSPGDRARRPGLRDRYTSVQLAKRTGLTVAAVYLLV
                     IALLGSWWLAFVGLMALTMGGGLAVFGGFLGWASASQLVGTVRGGLVSAEYLRTTKKVS
                     YGLRDAPYQHFYVYVGDDGEKVTYQRDAVSRSLAVLPTRRLWLVKGGGRTGMETHLSAL
                     WATPLSFVLLDLAVPLFLSGTAIVLYTCPGLLIRVLAG"
     gene            complement(28988..29638)
                     /locus_tag="ACTIVE_RS28375"
                     /old_locus_tag="ACTIVE_5682"
     CDS             complement(28988..29638)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018656744.1"
                     /locus_tag="ACTIVE_RS28375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5682"
                     /product="class F sortase"
                     /protein_id="WP_173097904.1"
                     /transl_table=11
                     /translation="MPESSARTAGRRRLQAAAAGALLTGLLLGGCGGGGGKAASSSSPA
                     PAASGTPGGTTAASNVSSLAPSEPVKITVPRIGVSAPVGQIGLKPDGRIEEPPLSRPNL
                     AGWYKEGPTPGEVGPAVILGHVDANKKAAVFFRLKELKPGDKIQVGRKDGTTATFTVER
                     SQSVNKDAFPHQKVFGESLDHPALRLVTCGGAFDPKAGHYTENLIVYARMTAS"
     gene            complement(29631..30365)
                     /locus_tag="ACTIVE_RS28380"
                     /old_locus_tag="ACTIVE_5683"
     CDS             complement(29631..30365)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_5683"
                     /product="hypothetical protein"
                     /protein_id="WP_173091509.1"
                     /transl_table=11
                     /translation="MRATRLSAAAVATGALVLGMAGPVLADSPGPVHPGAFCSPAGATG
                     KTAKGTPMVCAPGSDGKLRWKSGKGPTPPTTHKPLPPTTPKPVFRFGFDKVRLSSRVVA
                     PGRHTTFTVSCPSAVTITSNGYTRNPLPVRKTGKATWTASGTFKSSLPDPTVATVVCKG
                     FGSVKYSTHPSKNPSKGGNSMQPTTPKIPNGRIDTGDGSMYRPAAGSGAPLLAIGWGAL
                     AAAGLGAVALRRRTARERSTVA"
     misc_feature    30525..30538
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     misc_feature    30569..30584
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.72"
                     /tool="antismash"
     misc_feature    complement(30582..30596)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.44"
                     /tool="antismash"
     misc_feature    30602..30617
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.58"
                     /tool="antismash"
     gene            complement(30685..31245)
                     /locus_tag="ACTIVE_RS28385"
                     /old_locus_tag="ACTIVE_5684"
     CDS             complement(30685..31245)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017535312.1"
                     /locus_tag="ACTIVE_RS28385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5684"
                     /product="GNAT family protein"
                     /protein_id="WP_216857981.1"
                     /transl_table=11
                     /translation="MGDVELSDGVISLAPLRPEDAEAHLAGEDEPMVRWLSGGRSTRGD
                     VDAYIRHCQEQWDTGGSLRAFGIRAGSAGTLAGTVDLRFEAEGLGAGQVNVAYGIYPAW
                     RGRGLATRAVLLACGYAATAGGRQAVIQVEPENCASVAVARRAGFASAGYATGADGTRL
                     DRYVRDLPFTPDNAARSSTASGA"
     misc_feature    31675..31690
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     misc_feature    complement(31677..31690)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.5"
                     /tool="antismash"
     gene            31787..32611
                     /locus_tag="ACTIVE_RS28390"
                     /old_locus_tag="ACTIVE_5685"
     CDS             31787..32611
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="ACTIVE_RS28390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5685"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_173097905.1"
                     /transl_table=11
                     /translation="MSSRNEPYEAPAIQAFASELTAWREKAGLSKTALAETLGYTPQWI
                     CQVEAAKSIPSKDFAENLDTYFKTNGVFERQQKRIIETRHMAILPPGFTEYQQREAEAS
                     QIRTFELGLVHGLLQSEGYIRAVVGYDQEAETVERLVAERLKRQEILTRENPPNASFTL
                     DESALRREIGGPGVMREQLAHILALGERANVSIDVVPFNTGYYPGLIGSFTILSFSGAP
                     DVVYGEISGRGVLLQEPTIVSRFAVRYNSLRGEALRVRESRTLIKSVMEEYG"
     gene            32608..32817
                     /locus_tag="ACTIVE_RS28395"
     CDS             32608..32817
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630965.1"
                     /locus_tag="ACTIVE_RS28395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_173097906.1"
                     /transl_table=11
                     /translation="MTKPDLSTAKWRKSSHSGHDGGNCIEVANISPVVAVRDSKDPDGP
                     KLAFGASAWRAFAERIKADAHDLP"
     misc_feature    32890..32905
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.68"
                     /tool="antismash"
     gene            32891..33442
                     /locus_tag="ACTIVE_RS28400"
                     /old_locus_tag="ACTIVE_5687"
     CDS             32891..33442
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_5687"
                     /product="hypothetical protein"
                     /protein_id="WP_173097907.1"
                     /transl_table=11
                     /translation="MAMISEHGPAWTYIDYHQFFLTEPEQLDFVAEEVGDLISATGESV
                     IVHTGIANGHVAVHVQVHDDEPPLDEAGWEEIAEAAVQVENGPLMVRCLMEDAPDLPAL
                     TSGPGDYRVRAHARGRGIAYDACVHRSQEVYLFQVWPAPYLPLHVLEHTDHEQQRPAPQ
                     PCGAACARPARGRLFRARPT"
     misc_feature    complement(32917..32930)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.38"
                     /tool="antismash"
     gene            complement(33482..33775)
                     /locus_tag="ACTIVE_RS28405"
     CDS             complement(33482..33775)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="ACTIVE_RS28405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_173097908.1"
                     /transl_table=11
                     /translation="MNEHSPHYRWEPGTGRDSDEVRAGREEARLAFELGNAVRQRRLAL
                     GLTQSELARRAGMTQPALSRLESGGPTPTIGVLERLAHALDAKLKVEFTDAA"
     misc_feature    33748..33768
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     misc_feature    33753..33770
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.17"
                     /tool="antismash"
     gene            complement(33779..34138)
                     /locus_tag="ACTIVE_RS28410"
                     /old_locus_tag="ACTIVE_5689"
     CDS             complement(33779..34138)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012894658.1"
                     /locus_tag="ACTIVE_RS28410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5689"
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_173097909.1"
                     /transl_table=11
                     /translation="MELYGVEIEPEVREWLDSLPDREFGRVDWFVGLLAENAETLGEPW
                     SRHLGDGLRELRIHLHPHEVRITYWLASDRRVVLLTVFHKTKEREGAEVERAMRARKQC
                     EAEHAHARRNYIREV"
     gene            complement(34291..35250)
                     /locus_tag="ACTIVE_RS28415"
                     /old_locus_tag="ACTIVE_5690"
     CDS             complement(34291..35250)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012512.4"
                     /locus_tag="ACTIVE_RS28415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5690"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_173097910.1"
                     /sec_met_domain="PALP (E-value: 7.2e-68, bitscore: 228.2,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGVGEIEAAAELIAGHVVRTPTVPSPGLSDLLGVPVTVKLEMLQ
                     RTGSFKARGATAKLLGLGEAERAAGVVAVSGGNHAIAVAVMAAALDVKATVVMPRSAPA
                     RAVEIAESAGAAVRLADTVDAAFALMERLQGEGMTVVHPFDDPDVIAGQGTVGLELAED
                     AGELTDVLVSIGGGGLISGVAAALRARRPGVRVWGVETEGAETMSAALAAQGPVPVALS
                     SIVSTLSPPAVSQLTYEHVSALVNEVLVVSDAEAVQGVLDLAEHAKAWTEPAAGCLLPA
                     ARRVLDRVGDGARLGLVLCGANAAPATVTAQAAHFGLH"
     gene            complement(35292..35924)
                     /locus_tag="ACTIVE_RS28420"
                     /old_locus_tag="ACTIVE_5691"
     CDS             complement(35292..35924)
                     /NRPS_PKS="Domain: oMT (24-139). E-value: 9.2e-10. Score:
                     29.0. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS28420_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013382.4"
                     /locus_tag="ACTIVE_RS28420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5691"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_173097911.1"
                     /transl_table=11
                     /translation="MSDSVRMAEAFGELAGAYDHDHHDAVARALLELAPPAPGDAVADV
                     ACGAGAVALQVAARPPGPAPAVLAVDLSPDMIAVGRARAARQGCAGAIDWRAAPAVPLP
                     VPDSSLDLILCASSLHFLGMRALADWRRALRPGGRIGFTLPVASRFRPSGVFAELVAQD
                     LPLPEDAEQACSLATSAGFTDAGARTVTLGSRAVIAATAKNPHPDAV"
     aSDomain        complement(35508..35852)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS28420_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="9.20E-10"
                     /label="ACTIVE_RS28420_oMT.1"
                     /locus_tag="ACTIVE_RS28420"
                     /protein_end="139"
                     /protein_start="24"
                     /score="29.0"
                     /tool="antismash"
                     /translation="AVARALLELAPPAPGDAVADVACGAGAVALQVAARPPGPAPAVLA
                     VDLSPDMIAVGRARAARQGCAGAIDWRAAPAVPLPVPDSSLDLILCASSLHFLGMRALA
                     DWRRALRPGGR"
     gene            complement(36004..36573)
                     /locus_tag="ACTIVE_RS28425"
                     /old_locus_tag="ACTIVE_5692"
     CDS             complement(36004..36573)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547763.1"
                     /locus_tag="ACTIVE_RS28425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5692"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_173097912.1"
                     /transl_table=11
                     /translation="MARWEGNTRSRLERAALDLFAEQGYDRTTVAQIARRANLTERSFY
                     RWFADKREVLFAGDDLEQRFLAALDAVPAGTGALPALLAAFATAPEVFRPRDFLERRAA
                     VIAASPPLRERELIKLVALSEALTAALVRRGCEPQSARLATDAGLAVLRLATERWTADE
                     ETDFAEALSAGARDLLAVAAEAAPAG"
     gene            36666..37589
                     /locus_tag="ACTIVE_RS28430"
                     /old_locus_tag="ACTIVE_5693"
     CDS             36666..37589
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (12-174). E-value: 1.1e-30.
                     Score: 98.7. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS28430_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_179847451.1"
                     /locus_tag="ACTIVE_RS28430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5693"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_173097913.1"
                     /sec_met_domain="ADH_N (E-value: 2.5e-07, bitscore: 29.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTLRFHEHGAPLDVLRLEDAEPPEPASGMVRVRVEACGLTPADW
                     ALCGGLFPGDLPRGIGLEVAGTVDAVGDGVTGVGIGDPVFGPAPFTGPTAGASEQAVLE
                     MWFPRPPGLDPAGAAALPMAVETACRGLDALGVRDGMTVLVHGAGTTVGYAAVQMALQR
                     GARVVATAGETYAGALRAAGAEVTGHGDGMAERVAALAGGPVDLALDTAPVSGALPALV
                     RTVRAPEHVLTVSDFDAARKLGVRFSGPGGEGVMSHHVLGEYARLAAEGRFSIPVARTF
                     ALEDWRMAAELSQSGRARGKLVLEIG"
     aSDomain        36702..37187
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS28430_PKS_ER.1"
                     /evalue="1.10E-30"
                     /label="ACTIVE_RS28430_PKS_ER.1"
                     /locus_tag="ACTIVE_RS28430"
                     /protein_end="174"
                     /protein_start="12"
                     /score="98.7"
                     /tool="antismash"
                     /translation="LDVLRLEDAEPPEPASGMVRVRVEACGLTPADWALCGGLFPGDLP
                     RGIGLEVAGTVDAVGDGVTGVGIGDPVFGPAPFTGPTAGASEQAVLEMWFPRPPGLDPA
                     GAAALPMAVETACRGLDALGVRDGMTVLVHGAGTTVGYAAVQMALQRGARVVATAGET"
     CDS_motif       36843..36881
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS28430_0001"
                     /evalue="6.70E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="ACTIVE_RS28430"
                     /protein_end="72"
                     /protein_start="59"
                     /score="9.6"
                     /tool="antismash"
                     /translation="IGLEVAGTVDAVG"
     CDS_motif       37083..37145
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACTIVE_RS28430_0002"
                     /evalue="1.80E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="ACTIVE_RS28430"
                     /protein_end="160"
                     /protein_start="139"
                     /score="20.5"
                     /tool="antismash"
                     /translation="GMTVLVHGAGTTVGYAAVQMA"
     gene            37684..38013
                     /locus_tag="ACTIVE_RS28435"
                     /old_locus_tag="ACTIVE_5694"
     CDS             37684..38013
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_5694"
                     /product="hypothetical protein"
                     /protein_id="WP_173097914.1"
                     /transl_table=11
                     /translation="MADRKRAAQQALVDRVLGGDGRASADERARAFRDEGLEPPLDALI
                     GKVAGDAAQVTDADVAAAKASGRTEDELFELVVCAAVGRSARMYDAGLAALEEALAGEE
                     PGHAS"
     gene            38003..38584
                     /locus_tag="ACTIVE_RS28440"
                     /old_locus_tag="ACTIVE_5695"
     CDS             38003..38584
                     /GO_function="GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014664.4"
                     /locus_tag="ACTIVE_RS28440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5695"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_173097915.1"
                     /transl_table=11
                     /translation="MRLDVLNHGYRPGTKLLFAVVRLFSGHPLPDAAKLTFYRPDFYGA
                     RAKEFTHEAMRGPSAWSVGDRELMAAYVSKVNGSAFCIGAHTATATRAYQDEARVTAVL
                     DELDAPPVEEPLRSTLRMLGRLVRDGQVAAADMREVLAAGATPEQVRDALAVCAAFDTT
                     DRLADAFGFELLSPEGYAAGAKFLLKRGYR"
     gene            complement(38588..39211)
                     /locus_tag="ACTIVE_RS28445"
                     /old_locus_tag="ACTIVE_5696"
     CDS             complement(38588..39211)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852730.1"
                     /locus_tag="ACTIVE_RS28445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5696"
                     /product="LysE family translocator"
                     /protein_id="WP_173097916.1"
                     /transl_table=11
                     /translation="MMSSLVAFVGAAFLIAMVPGPSTAVILRRAVMNGRVNGMATVLGN
                     ECGVLLWGLAAAFGLSALLLASRLAYDAMRITGAVVLVYMGARALWKARHATEAEEEAP
                     QPSAVSHGRAFWQGAITNFANPKAGVFAVSFLPQFVPHGAPVLATLVLFSMIWAAIDMI
                     WYLPMVWLAGRARTVLQRASVRRRMEQVSGIVLVGLGIRLAAES"
     gene            39451..40017
                     /locus_tag="ACTIVE_RS28450"
                     /old_locus_tag="ACTIVE_5697"
     CDS             39451..40017
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03083.1"
                     /locus_tag="ACTIVE_RS28450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5697"
                     /product="TIGR03086 family metal-binding protein"
                     /protein_id="WP_173097917.1"
                     /transl_table=11
                     /translation="MDDVIERIDRALTATAAVVGGIGAARLAAPSPCPGWDVRDELNHL
                     VGGMRIFAAELTGTAAGADHEADWLGGDPHAAFGRAAGLDRAAWRRPDALQGTVRLGFG
                     EVPAPMAALIHLTEVLVHGVDLAVATGQDALADDAACAHLLTVMQGMDFGAFRRPGMFG
                     PERTAPAGAPAHRRLLAFLGRDLAR"
     gene            complement(40072..40542)
                     /locus_tag="ACTIVE_RS28455"
                     /old_locus_tag="ACTIVE_5698"
     CDS             complement(40072..40542)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1298: putative carboxymuconolactone decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009081960.1"
                     /locus_tag="ACTIVE_RS28455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5698"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_173097918.1"
                     /transl_table=11
                     /translation="MSARIDFYGNDLAMKVAKYLNSAGKAVADSTLPVATQELVRIRAS
                     QINGCGYCLDMHTKDAAAAGETQQRINLVGAWREATVYTEAERAALELAEEGTRLADGA
                     GVSDATWANAAKHFDEEQLAALVGTIAIINTYNRLNVITQQPAGDYVPGQFA"
     gene            complement(40618..41700)
                     /locus_tag="ACTIVE_RS28460"
                     /old_locus_tag="ACTIVE_5699"
     CDS             complement(40618..41700)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657892.1"
                     /locus_tag="ACTIVE_RS28460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5699"
                     /product="S1 family peptidase"
                     /protein_id="WP_216857982.1"
                     /transl_table=11
                     /translation="MAAASAAVAGAAALIAGSLYAVHGGQGPQAAKLAGADRPRTGPAR
                     AGSGDSAALAARVAGRLGDRTAGGYLDAAGRPVVTVTGAADAAMVRSAGAVPKTMRTSP
                     RTLHRATAALRRTMAGTPGTGWAVDPATSQVVMWTDGSVTGPRMAAARRAAAGLGAAVR
                     MVRVPGRLRTLALGGDAIFGGGARCSLGFNVQRAGRPFFLTAGHCGNIVQDWTADQEGA
                     QALGTTVQSDFPGNDFALVQETAGAQSAVDLHDGTAQPITKAADAVVGQRVARSGSTTG
                     VHTGRVTAVGATVNFPEGTVTGMIQTTVCAEPGDSGGPLFSGSTALGLTSGGSGDCRTG
                     GVTFFQPVTEALQAFGAQLP"
     gene            41956..42246
                     /locus_tag="ACTIVE_RS28465"
                     /old_locus_tag="ACTIVE_5700"
     CDS             41956..42246
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_5700"
                     /product="hypothetical protein"
                     /protein_id="WP_173097920.1"
                     /transl_table=11
                     /translation="MKIPSPLRSAVLTAAGLAMAAGLAAFAPAASASAAETAAAVQSHP
                     RHCPWGTHWDMRWHRCVRDRDDHGHGDHGGWHHGHGDWHHGHGHWHHGHRW"
     gene            complement(42340..42777)
                     /locus_tag="ACTIVE_RS28470"
                     /old_locus_tag="ACTIVE_5701"
     CDS             complement(42340..42777)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ACTIVE_RS28470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ACTIVE_5701"
                     /product="hypothetical protein"
                     /protein_id="WP_216857983.1"
                     /transl_table=11
                     /translation="MNTREESIVSGGERTGTSADEPGEGALAVALRGLAAGRIVLGAAA
                     LVAPNAMAKASGVRPTPELGYMTRIFGARAIALGLGYLTASGRDRSRWQRLALLVDVID
                     TAHGAARLARGDLPRPTALGYTALTGAYMAVGATRLARDLA"
     misc_feature    42818..42831
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.36"
                     /tool="antismash"
     gene            42833..43573
                     /locus_tag="ACTIVE_RS28475"
                     /old_locus_tag="ACTIVE_5702"
     CDS             42833..43573
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /locus_tag="ACTIVE_RS28475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5702"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_216857984.1"
                     /transl_table=11
                     /translation="MRLWVRLGHVVYVGPALGLGPHATAVACLGVGLDAPFTVRAGGLP
                     ERTVRSFLFRARVRHEVVGGTGRMLFCFFDPTSARMARCLGGMRRTAGGFGSDHHREAD
                     LIGLAGRDDVDLERLLAAASIPVATARDPRIARVAARIRDDPARPQRAEAAAREAGLSR
                     SHFLRTFSGQTGTSFRRYVQWARILRVAEAYAAGHDFTRAAADAGFASPSHLSGAFRGM
                     FGLTPSALAALGPEVVLDEPGRVP"
     gene            43742..44224
                     /locus_tag="ACTIVE_RS28480"
                     /old_locus_tag="ACTIVE_5703"
     CDS             43742..44224
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634590.1"
                     /locus_tag="ACTIVE_RS28480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5703"
                     /product="cation:proton antiporter regulatory subunit"
                     /protein_id="WP_173097922.1"
                     /transl_table=11
                     /translation="MDVERTALPGIGLQHVMTTERGRQLGIISHRSGRRDLVVYDREDP
                     DSCVATVALTAEEANAIAELLGTGRIVEHLAELHRQVEGLVTEQLPIAPGSPYVGRPLG
                     DTQARTRTSASIVAVVREGQVFASPRPDFVFAAGDVVVVVGTGEGTAAVAAILADG"
     gene            44231..45475
                     /locus_tag="ACTIVE_RS28485"
                     /old_locus_tag="ACTIVE_5704"
     CDS             44231..45475
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079552.1"
                     /locus_tag="ACTIVE_RS28485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5704"
                     /product="cation:proton antiporter"
                     /protein_id="WP_173097923.1"
                     /transl_table=11
                     /translation="MESAVQLIELGAIILALGVLGAVSVRFSISPIPLYLIAGLAFGSG
                     GVYPLTTSEDFVSIGAEVGVILLLFTLGLEYTADELVGTLKTSAPVGLADMALNALPGV
                     AAALLLGWGPVAAVAMGGITYVTSSGITAKVIGDLGWLGNRETPALLSVLVFEDLAMAA
                     YLPILTALLAGAGLVGGAVALAVAAATIAVILFVALRHGAWVERFVSSPSEEVLLLKVL
                     GLTLLVAGIAQQLQVSAAVGAFLVGIALSGSLAHTAHKLLSPLRDLFAAVFFVFFGLHT
                     DPHDLPPVLGIAAVLAAVGIATKLATGWFAARRAGVAATGRLRAGVALVPRGEFNIVIA
                     GLAVSAGTNARLGPLAAAYVLILAVAGPVLARGVEPLTRTVRARRTARRERTPQTDDDV
                     PVAPAPRPGPAGGGR"
     gene            complement(45479..46378)
                     /locus_tag="ACTIVE_RS28490"
                     /old_locus_tag="ACTIVE_5705"
     CDS             complement(45479..46378)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="ACTIVE_RS28490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_5705"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_246343193.1"
                     /transl_table=11
                     /translation="MHEGGPDRVRLEQAEVEVFLALAGELHFGRTAERLRISQPRVSQL
                     VRSLERRIGGRLFERSSRRVELTPLGERLLESAAPAYDALVLALTDARNIARGLRIGFL
                     GPFFSTLDAAIAAFRERHPACQVRTVQSSWTDPFAPLRSGEIDLLVCPWPVEQDDLRTG
                     PVVAEYPRLLAVAASDPLAARPSVDLEDLAGVRVIAAPPSGPPEWLRSFWPPERTPTGQ
                     PIPRAGQARTEPEMLSLVAQGAGVFVASTAMARHFSHPGVAFVPFTGMPPSRAVLVWHA
                     GNPNRRVAEFAGIAAGTG"
     misc_feature    46390..46404
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
ORIGIN
        1 cccgcctcca gcgcgtcgcg ctcgcgcggc gacagcgggt tcgggccggc gctgagcgcg
       61 gcggcggcga gcgccgggtc gatgacgcgc tcaccggcga cgacgcggcg gatcgcggcg
      121 gcgagctcct gcgccgggcc gtccttcacc aggaacgccg acgcgcccgc ctccatcgcg
      181 cggcgcaggt agccgggccg gccgaacgtc gtcaggatca tgatccggca gccgggggcg
      241 gcggcgcgga tctccggcgc cgcgtcgagc ccgtcgcggt ccggcatctc gatgtcgagc
      301 agcacgacgt cgggccgggt gcgggcggcg accgcgacgg cctccgcgcc cccggacgcc
      361 tccccgacga cctccaggtc gtcctccagg ctcagcagcg ccgccagtgc gccgcggacc
      421 atccgctggt cctcggcgag catcacgcgg atcacatggc ggactctacc gccggccgct
      481 ccgccccggc cggggccagg gggacgcgca ccgcgagccg gaagccgccg ccctcgcgcg
      541 ggcccgccgc cacggtcccg gccgcgtccg cgacccgctc cgccaggccc tccaggccgt
      601 gccccggcag gtgcccctcg ctcacctcgc cgcgcccgtc gtcgacgatc tccagggtgg
      661 cctcgccgcg ctcccgggcg accgtgatcg tgacgcggcg ggcgcgggcg tgccgcacga
      721 tgttggtgac gccctcccgg acggcccagc cgaacagccc gtcgacctgg tcgggcagcg
      781 gcgccccgga cgtccgcacg gcgacctcga cctccgcggc cgacagcacc gcgcgggcgc
      841 cgtccagctc ctcggtgagg tcgcgctgcc ggtagccgga gatcgcggcg cggacgtcgg
      901 cgagggaccg gcgcgccacc gactcgatgt cggtgacctc cgccatcgcg cgggcggcgt
      961 cccgctcgcc gagccgccgc gccagctccg ccttcagcac gatcagcgac aggctgtgcc
     1021 cgagcaggtc gtgcaggtcg cgggcgatgc gcagccgctc gtcggcggcg gcgagccggg
     1081 cgacctcgcc gcgcgcgatg cgcagctgct ggacgagggt gcgcgcgtgc cggaacgcga
     1141 ccatgaacag cccgagcgac agcgtggtga gcgcgatggg ccacagcgcg cccggcacgc
     1201 cgagcagcgg gcactgcacg gcggcgagcg ccatggaccc gccgacgccc cacagcaccc
     1261 ggttcatcgg cagcgtcatg gcgaagacca tcgacaggta gatcgaggtg cccagccagg
     1321 ccgggccgaa cgcgaacggc agcgcggcgg agagcaccgc gaacgccgcg agcaggacgt
     1381 acgtgcgggt cctgacgggt tcgagccagc tcctcaggct gagcggtgtc gcgaggaaca
     1441 gcgcggcgaa ggcgatcagt cccgcgatgg ccagggccat gcgggcaccg gagtagccgg
     1501 cgatgtcgat ggtgaccgga aggagataga tcagtccggt ggaggaccag aacgcgcgcc
     1561 gccgccgggc cttcccgggg tcggcgtcgg caatgccccc gctgtcgagg aacctcatgg
     1621 tcatgacgct cgcatcgtat gccggtgggc ggtctgggcc gcgccgtgga tccggacggg
     1681 ggcgaagggg atggcgtcca cgccgtcaac gctacgaatg cgcaggccgg gcggttagtg
     1741 aacgttgtcg tgggtccggg atgacttttg tcatggccgc cttgcccgcg catggggtct
     1801 ggcctccccg cgctttacat gttacgaagg tatgtaaagc ggtgggcgga gcacacccgc
     1861 gtcgcgacgc tgcggcgcaa ccccccgagg aggatccccc gtgagttcct acgacctcta
     1921 caccacgccc gtgcccacgg agacgtggaa cgtcccgatg tccggcgagg cccggttcac
     1981 ctgggagtac gacgagggcc gcgaccggct gctgagcctg taccagaagg gcaaggacaa
     2041 gcagtgggac gcgacgaagc gcatcgactg ggacctcgag gtcgatccgg tcaacgtcgc
     2101 cggcctgccg gacaacttca accccctcat cggctccgac atctgggaca agatgtccca
     2161 gaaggagcgt gacgagttcg gccgccacca ggggtcctgg ctgttcagcc agttcctgca
     2221 cggcgagcag ggcgcgctga acgtgtcggc gcgcatcgtc cagtccgtgc ccgacctgga
     2281 ctccaagttc tacgccgcca cccagacgat ggacgaggcg cggcacgtgg agctgtacac
     2341 caagttcctg cacgagaaga tcgggatgta ctacccgatc aaccaggacc tcgcgaagct
     2401 gctcgccgag tcgctggagg acagccgctg ggacctgccc tacctcggca tgcaggtgct
     2461 catcgagggc ctcgcgctcg ccgcgttcgg gctgtaccgc gacatgtcga cgaacccgct
     2521 ggtcaagcag ctgctcgcgt acgtcatgca ggacgaggcg cggcacgtcg cgttcggccg
     2581 gctggcgctc aaggactact acgcggagct caccgagaag gagcgggccg agcgcgagga
     2641 gttcgtggtc gagggctgct acctgatgcg cgaccggttc aagggccgcg aggtgttcga
     2701 gcagatgaac atgccggtcg acaaatgcat ggaatacgtc gacaactcgg atatgtacac
     2761 gctctatcag tcgctgctct tcagccggat cgtcccgtgc gtccgggacg tcggcctttg
     2821 gggcgacaag gtgaaggccg cctatgccga catgggcgtc ctcgacaatg ccaaggccga
     2881 cctcgaggcg ctgatgcgcc aggacgagga gatcgccgag aaggtcgacg aggagaagta
     2941 cgccgccgag ctggccgcgc gcaagaccga ggtcgacgac gccatcgccc tcggcgccga
     3001 atgacctgac gcccggcgcc ggaacggcgc cgccgtaccg gcggcgggat ggaacgcggg
     3061 gacgcccacg ggcgtccccg cgtcgcattt ccgtagatct ttaccgcccg cccctgatcg
     3121 attcccccat tcggcttgcg cggcatcacg gctgtactaa cgtgcccgct cgacggtgcg
     3181 ccggaaaacg aacgccatgg gcgcacgcac accgcgcaga gtcgatccga gaatttcggg
     3241 ggaaaagaca tgaaccgatc cgccaggaaa ctgctcggcc tgtcggccgc ggcgccgctg
     3301 gccgccgcgc tgacgctggc cgcggcgccg gcgtacgccg tccagggccc ggccgccgac
     3361 ctcgtctacg ggacggtcgg ccaggtcggc ccggcgctgc cgccggcgcc ggtgcccgcc
     3421 ccggtctcgg acgccgcgag tcgcaccgcg gaggccgcga ccggcaccgc cgacggcgcg
     3481 ctcgccgcgg cgccgcgtcc cggcggcgcc ggcctggccc cgcgcctgcc cccgtctctt
     3541 ctacaactct gacgcttccg acgaagagca tagtgggaat atcacagatc tccgagnnnn
     3601 nnnnnnnnnn nnnnnnnnnn ngcctggccc cgcgcctgcc cgtgtcccgc accgcgccgg
     3661 ccgcccgcac cgcgtccgcc ggccccgccg cccgcgcctg ccggctcgac gcgacgaaga
     3721 ccgtcgacgg cacccgcgtc acgcggctgc tgccgagccg gacgatggcc ctgacgcccg
     3781 gccgggacgg tgcgccgatc tccgcgccgc gcagcggcaa ctgcctcggc gcggccgacc
     3841 gcaccgcctc cgggcccggc ctcgggtccg gcctgccggc gccggtcggg gaggccgcca
     3901 aggtgcccgg acgggtcgtc gggcgcgtca cctccgtgcc gaagcgcgtc gtgggcagca
     3961 aggtcgggaa gatgggcggc ggcgcggtgg cgctgccgaa cgcccggtcc ggcgcgtccg
     4021 gcggcggccc gctcggcgac gcggtggacc tcgggctgcc gggcgacgcc tcctcgctgc
     4081 gctccgccgc gccgatctcg atggtgttcc cggacggcgt cggggcgcgg cggtcccggc
     4141 cggcgccgca gaacctcgtc ggcgaggcga acgacacggt gaaccagatg cactcgcagg
     4201 tcggcagcgt cgtcaacgtg ctgaagacgc gcgagcggcc gtccgacacc gggcgcgccg
     4261 gggacggcgg cctggccggc ggcgggctgc cgggccaggg gctggcggac gggctgtccg
     4321 gcccgccggt ctacctgccg aagctgccgg cggtgcgctg accgccggtc cggcgattca
     4381 ccctcttaac ggggcgtttc ggagatgcca ggtgcatccc ggaacgccct gttttattgc
     4441 caaacgaacg cttgttatat gtccgagatc acaccttcca tggcgagtaa attggatctt
     4501 gaaatgcgct cacccagcga agtggatcag cttcacaggg caaaaagaga ggtgacaaac
     4561 cccacaaaga ccgggcccgc gcttgattca ctccgggcgc aacgtacggt caaggacttg
     4621 tgcggcgctt tcgagatcaa aagtgaagat gcaacgcagc cgcacctgcc ggacgccgaa
     4681 gccgcgatga cgcggacgcg ctgagcgaga gcgcggagac gggcactgaa gcccatcggc
     4741 ggcgcgggac cagggggacg aggaggtcgc cccggcgcgc cgcgagaacg gcgctgagaa
     4801 acgcctgggc gtccggggtc ctgtccccta ccgaaggatc cttcgtgggc aaccctgacg
     4861 aacgaccccg tcttcacgcg cgccttcagg cccgtcttcc gcggccgcga acgcgcaccc
     4921 tgctgatctt ctccggcgtc gccgcggccg ttctcgcggt cggcgccttc gccatcgtca
     4981 acggcggaaa ggccccggcc gactcggccc aggccgcgca gaccgccccg caggcgacca
     5041 ctccggtcgc cgacccgccg cggccggagc cgtcccgggc gagccgcggc gagccgcgcg
     5101 acccggaccc gaagcacaag aagaaggccg cgcccaccaa gaaggcccgc ccggcggcca
     5161 ccgccgagca caaggccaag ccgcagaaga agacccgggt gctccagtcg ggcagctgcg
     5221 aggcgtcctt ctacggcgag gggcagatga ccgcgagcgg cgagccgttc gacccgggcg
     5281 cgctgaccgc ggcgcacaag acgctgccga tgggctccaa ggtccgcgtg atcaacaaga
     5341 acaacggcaa gtcggtcgtc gtccgcatca acgaccgggg cccgtacgcg ggcggccgct
     5401 gcctggacct gtccaccgcg gccatgaaga aggtcggcgg cacgggctcg ggcgtcatcc
     5461 cggtccgcta cgaggtcctg tccaagggct gagtcccacc gcacggtgaa ggcccgcctc
     5521 gcgggcggct cgacgccgcc cgcgaggcgg gctcacgcat gcgcccggtc agcgcgcggc
     5581 gcgcgccggg gcggggtagg gcgcggtgtc gacggccgtc gtgtcgacgg gttctgcgtc
     5641 gacggattct gggtcggcgt gcgcggagtc cccgggcacg gcgtcggcag ggacggcgtc
     5701 ggcagggacg gcgtcggcgg ggacggcgtc ctggtccggc tcggcgcgga cgtcggcgag
     5761 ccgctcccgg aaccagtcgg tgagcaggcc gtcgacccgc accgcgtcgg tgatcggcgg
     5821 ccgcggctcg gtgccgggct cggcggccag cgcgtgcccc atccggaacg tcgcggtctc
     5881 caccgcgccc gcgccgcgcc gctgcaggac gtcgcggaac gcggtgacct cgcccgccgg
     5941 gaccacccgg tcgcggccgc cgccgaccag cagcagcggc acgtcccgcg cggcgatgtc
     6001 gccggcgagc gcgccgaggt cgaggcggtc ggcgagctcc tgcgccggcc cgctccacgc
     6061 ccggtcgcgc cccgcgcggc gctccaccgc ccgcgccgcc cgcgccgggg cgacgacggg
     6121 cgcgacggcg gcggccgcgc tcaccgcgac ctcgccgcgc gcgagggcca gcagnnnnnn
     6181 nnnnnnnnnn nnnnnnnnnc gccgcgcgcg agggccagca gcgccgcggc gccgcccgcg
     6241 ctgaacccgg cgagcgcgac gggcccgtcc ggcagcgcca ggtcgcggcg cagctccgcg
     6301 accgcggcgg gcagcccggc cgcggcctgc tcgacggcgc ggccgtacgc ttcgatcgcc
     6361 tcggtctcca ggatcgcgcc cgagccgagc ccgcccggcg agcggccggg caggtcgagg
     6421 tacgcgcgcc acaccggcac gccggtcatc ggcaccgccg ccgccagcgc ggccgcggtg
     6481 cgcggcgggt cgaaaccggg ccaggcgatc atcagcaggg tcggccccga cgccgtcgcg
     6541 tccaccgcgg tcggcggcag cgccacatag gcggcgcccc ccgccgtgcc gtggacgggt
     6601 ctgttcacat ggtcgccgct catgtcgtgg atcagctcct gccgtgctcg acgggcggtg
     6661 ccggccgtgc ctcggggagg cggcgctcct ccctctcggg acctctcatg ctggcagcgg
     6721 ccgccggaga atgctccgca atcaccgcac gttgcccgcg agagtgacga agaactcact
     6781 tccggtaacc cgaaaccgcc ccgtccgggc ggccggttgt gatccgggac tcatgaccgg
     6841 tcgaagggaa caaaaccggc atcggtcgcg tcatagaggg acgtgggcgc tgcgggggcg
     6901 cgccctcacg acccctgacc gaggagtacc tgtggacagg aatcgcagga cggccgccgc
     6961 cgggcaggcc tggcagatct acagcgagac cctccagccc gacgtgcccg gcttctggga
     7021 gcggttccgc gccgtgccgc gcatgctgaa ggcggtgctg cggggccggt acaagggcat
     7081 gtcgttcggg acgctcggcc tgctcgcgct cggcctcgtg tacatcatct ccccgatcga
     7141 cgccatcccg gacgtcatcc cgatcgccgg catcgccgac gacaccggcc tcgcgctgtg
     7201 gctcgcggcg gtgctcgtca agtccgccgg cgacttcgtg atgtgggagc gcagcggccg
     7261 cccgaccgtc atcgtcggcg agccgatcga ctagcgccgc ggcgagccga tcgaccaacg
     7321 cggccgccgg cgctcaggcg ccgccgagtt ccttggcgaa gcggctcgcc gcgtcccgga
     7381 cgatgggcac gacgtcggcg acggcgtcgt gcgtcatccg ggcggacggc cccgacaccg
     7441 agagcgccgt cagcgcgggc gcgccttgca gcggcacggc gacgcaccgc accccgatct
     7501 cctgctcctc gtcgtccagc gcgtagccct gctcccggat ccggtgcagc tccgcgagta
     7561 gcgcgtcctg gtcggtgaac gtgttcggcg tgtgcgccgc catccccgtc cggccgagga
     7621 tctcccggac ccgctcgtcc ggcagctgcg acagcagcgc cttccccacg cccgtgcagt
     7681 gcggctgcac ccggcgtccc acctcggtga acatccgcat cgagtgcttg gacggcacct
     7741 gcgccacgta cacggcctcg tcgccctcca gcacggccat gttcgcggtc tcgcccacgt
     7801 cgtccaccag ccggccgagg acggggcgcg cccaggtccc gagcagccgg ttcgcgccct
     7861 cgccgagccg gatgaggcgc ggcccgaggg cgtaccgctt cgacggctcc tgccgcacgt
     7921 acccgtggtt caccagcgtc cgcatgagcc ggtagatggt cggcatcggc agcccggaca
     7981 cctcggtcag ctccgacagc gccatctcgc cgcccgcgtc cgccagatgc tccagcagct
     8041 cgaaagcgcg ctccagcgac cgtacggcct ccgccacccg cgtctcctct cctcgcgatc
     8101 ccccgattct acggagatcc gatttcactg cgcgaaagag ggtgtccgcg gagagagaac
     8161 gcggggacgg acgttacgca tggcgacact gtggaaacaa atgactacgc acggcaatga
     8221 accggaaccc ccctggcagc aagagagaca gcgagaaccg cgagagggga cagcgtgcgg
     8281 accggtggca gcaggacacg cagcagggcc cgcgtcggcg cgatcatggc gggcggcgcg
     8341 ctcgccgtcc cgccgatgat gatgctcggc ggggccgccg cgaacgcgaa cccgtccgcg
     8401 gtccggctgc tcgccgagac ctcgacgtcc gccggcgccg tcgccgggcc cggctacgcg
     8461 ctcggccaca ccgtccgcgt ccacgccgag ggcggcaccg cgcaccacgc cgtcctgcgc
     8521 atgctggccg ccgatccgct gacctgggcg aaccggcccg cgggctgcgc ccggctcgac
     8581 tccgggcgcg agctgcgctg cgacctcggc gacgtgggcg gcgcgaccgt gacgcggacc
     8641 ggcaccgtcg cggtcccggc gtccgcggtg ccgcggcgcg cgcccgggag ccggcccgcc
     8701 atcctcaccg tcgccgccgc ggacaacgcc gcgcccacca cgtcccgcgc cgtcctcgac
     8761 ttctcgccgg gcggcgagag cgggtcggcc accgccgacg atccccccgc ccagccccag
     8821 cccgccccca atgaaggcga cgcgcactgc tccgccgacg ccaagccctg ccaggacgcc
     8881 gtccccgagg gccaggcacc gccccagcag agcgcgcagc agagcgcgcc gcagaagggt
     8941 gacccgcaat gccgcggcat cgccgacgcc gaccggccga agggcgcact ccccgcctcg
     9001 ccctgccaca acaccccgtc cccggccggc acggcccccg ccggccaggc cgaaccggcg
     9061 cacgaaggtc gtcccgcgca caacgggcga cccccgcacc acaaccgccc gcccgacgag
     9121 ccccgccccg ccctgcagcc cgccccggcg aagccccgcc accacggcca cccgtccgcc
     9181 cagggacaac cggcgcaccc ccgccccatc aagccgttca cgcacgggca gccgcacccc
     9241 ggcaagccgt ccactccgcc cttcacggac gagcagccgc cggcacctca cggcaacaag
     9301 ctcccgcacc acagcgcacc gagccgcccg gccgcgccga agcaccccgc ctcgtcccag
     9361 cacagcacgt caccgcaggc cggcgagccg acccagcaca acgtgacgat ctacggcgac
     9421 gcgcctgcgg gcgccgccgg ggggagcaca gcgcacgggc accacacctg gtcgtacggc
     9481 gaccaagcgc agtccgagac cggggtgccg tggggtgcgc ccggcgccgg caagcacaag
     9541 catcacgccg gcgcgtccgc gggaagcgtt ccgtcgacgg aggatgagta cccggccgac
     9601 gggtaccccg ccgacgccta cccggccggg gcggacggcg gcgccggcta cggcggcagc
     9661 gccggaggcg ggcacgtgaa gccggggcag gtgccggagc tgcccgccgg accggcgccg
     9721 gcgcggccgg gcgtcgcgct cccgccgctg accgcgccgg gggcgatgcc cgcgccgaac
     9781 agccaggcca tggcgggcac cacgagtgac ggcaccgacc acggcgacgg ccggatgacg
     9841 ctggtgtcgc cggtcgggat ggagcagggc aacgggaccg actgggccgt ggtgctcggc
     9901 gtcgcgatcg tcgccgagat cgggctgctg tggggcgccg cctgcttcgg cctgtggcgg
     9961 cggcgcatcg cgctctaccg ggcggagacc cgggcggccg aggcccgcgc cgaagccgcc
    10021 gcccaaggcg gcgcctacat ctgaccccgc gttccgcgcc cctgccgtgt tgcggccggg
    10081 acggggtggc gaggggaacg gtgggacggg tgccggcggg ggtgcgaatc ggtggtggat
    10141 gtcgcggcac ggtgccaaat gggggaccgt gtcactaagc tgatccgctg acagtaaagc
    10201 tgcggttgcg gacaggggat ccggtatgtc agaggcgacg atgcagtgcc cgaagtgcga
    10261 gtccaagctc gacacccatg aacggcacgg cgtggtcatc gaggaatgcc cgggctgcaa
    10321 gggcgtgttc ctcgaccgcg gcgaactgga gcagctgatc gacgcggaga gccgctacct
    10381 ggccgaactc cccgaggccg agaaccccga caccacctac cagggacggc accgccgcgg
    10441 gatcatgcag cagatcttcg cggccgaccg gtagtccgca cacggtcggt aacggcgtcg
    10501 gcgcccaggc gtgaaaaggc atttcctctt gtcacggggg tgacaaaccc ggcgccgccg
    10561 aatgtggtgc gcagctaata tcgcgcgctg cctaccatcc ggtagcttca cgatcatcgc
    10621 cggttgccgg ggggcgccag acgagtcgtc cggccggccg cacgcaccgc cgacggcgcc
    10681 caccccccac gatggccccg cccggcccgt cccctcggga gattgatcaa tggcattggg
    10741 ctcgctgctt cccgaactcc tgcccggcgg ttccggccgc accccgctga tcgagcgggt
    10801 cgcgcggtgg gcgagggaga agccggacgc cccggccttc accttcgtcg actactcgct
    10861 ggacccggcg ggcaggcacc tcacgctgag ctgggcggag acggaccggc gggcccgcgc
    10921 gacggcgacc gcgctgcgcc aggtgacggg gccgggcgag cgggccgcgc tgctgctgcc
    10981 gcagacgctc gagtacatga tgacgatgct cggcgcgatg tacgcgcacg tcatcgcggt
    11041 gccgctgttc tcccccgacc tgccggggca cgccgaccgg ctgatcgggg cgtacaccga
    11101 cagcgagccc gcggtgatcg tcacgacccg caacgcgctg ccgcacgtgg agaagttcct
    11161 cgccgaccac gatgtcccgc agccgaagga gatcctgttc gccgaggagg tcgacctcgg
    11221 gctcgcggac tcctgggagg acgagccgat cgggttcgac gacctggcgt acctgcagta
    11281 cacgtcgggg tcgacgcgcc gcccggcggg cgtcgagatc acgcacggga acgtgacggc
    11341 gaacgcggcg cagctgtggt cggggtgggc gccggacaag ccggacccgg agctggtcag
    11401 ctggctgccg ctgttccacg acatggggct gatcgcgacg atggcgctgc cgctggtgcg
    11461 cggcgaccac gcgatctaca ccgacccggt gtcgttcatc atgaacccga tgcgctggct
    11521 gcagctgatc gcggggcggc cgggcaagaa cgtctacacg gcgggcccga acttcgcgta
    11581 cgagtacgtg gcgtcgatgg cgtcgccgga gaagctggcg ggcctggacc tgtccgggct
    11641 gacgacctgc ctgaacggcg cggagccgat ccgcacgtcg acgctgtcga cgttcgcgga
    11701 ggcgctggcg ccggcggggc tccgcccggg cgcgcaggcc cccgggtacg ggctggcgga
    11761 ggcgacggtg ttcgtcaccg cggcggccga ggacgtcccc ccgaagatca tctcggtgga
    11821 ccgggaggcc ctgacgcagg gcgaggtgcg gctgtgcgct gcggacgcgg agcgcgccag
    11881 cacgctggtg tcgtgcgggc ggccgtccgg gcagctcgtc gcgatcgtcg acccggacgc
    11941 gagcaccgag cagcccgacg gccgggtcgg cgagatctgg gtgcacggcc cgaacaccgc
    12001 cgccgggtac tggcgcaact ccgagcgcag ccaggacacc ttcggcggcg agctcgccga
    12061 gccgggcgag ctgcccgccg ggccgtggat gaagaccggc gactacggcg tcgtccacga
    12121 gggcgagctg tacgtcaccg gccgcatcaa ggacctgatc atcgtcgacg gccgcaacca
    12181 ctacccgcag gacatcgagg tcacggcgca ggaggcgcac ccggcggtgc ggcccgacca
    12241 cgtcgccgcg ttcgcgctgc ccggcgagga gaccgagcgg ctcgtcgtgg tcgccgagcg
    12301 gaaccggcgg gtgccgctcg gccggctgga cctggacgag gtcgaggcgg cggtgcgcgg
    12361 cgccgtgaac gtcgagcacg agatgagcgt gcacgcgttc ctgctcgtcg agccgggcgc
    12421 ggtgtcccgc acgtccagcg gcaagatcgc gcgggcggcg acgcggcagc ggtacctgga
    12481 cggcgcgctg cccaccacgg cggcgcggct ggcgtcccgc aagtagtctc ggcctcgcac
    12541 gcacgggcga ggcccgccgt acggcgcgcg ccgtacggca tcggctcgac aggggccgca
    12601 gggcgcggcg ccccgcggcc gtgacgacac aggaggacca tgctctcggg gctggggcgt
    12661 ctgatccatc ggcggcgctg gatcagcctc gtctgcatcc tgctgctgac cggcgtggcc
    12721 ggcgcctggg gcctcggggt gttcgcgaag ttcaaggcgg gcgggttcga ggacccgaac
    12781 gcgtcctcga cgctcgtcgc gcggctcggc gccacctact tcggcagcac gaaccccgac
    12841 gtcctcgtcc tctacaagag cgacacgatg acggtggacg acccgcgcta cgaggcggcc
    12901 gtcgtcacca ccgtcgcgcg gctcccgaag gaccgcgtcg aggagctcat ctcctactgg
    12961 gcgctggacg agaaggacgc ggtgtcgttc gcgtcccgcg acaagcacga gacgttcgtc
    13021 gcgctgaagc tgaagggcga cgacccgacc aagctgaaga actaccagga catcaaggag
    13081 cggctgaagg cgcccgggct gaccgtccag ttcggcgggg ccgtgccgct cgggcaggag
    13141 ttcggcgagc aggtcaccgc cgacatcgtc cgcgcggagc tcatcacggc gctgccgctg
    13201 ctgaccctgc tcgtgttgct gttcggcgcg gtggtggcgg cgtcgctgcc gctgttcgtc
    13261 gcgctgttct cgatgatcgg cggcctcgcc gtcctgcaca tcgtcaccta cgccgccgac
    13321 gtgacgtcgt tcgcgctcga ggtcgtcacg atgatgggcg tcggcctcgc gatcgactac
    13381 tcgctgttca tcatcagccg gttccgcgag gaactgcagc gcggcatggc cgcgcaaggg
    13441 gtcccgccag ggaaaccctg gaaacgagaa cgcgacaaac aggcgcgtaa ggcggcgaag
    13501 aaggcgcacc gggaggcgat gcggccgctc cgcgaggacg cgctcgccgc gaccctcgcg
    13561 accgccggcc gcaccatcat ggtctccggc gtcaccgtgt ccgcggccct cgcgggcctg
    13621 ctgctgttcc cgcagatgtt cctgcggacg atcgggctcg ccggcatagc caccgtcatg
    13681 gtcgccgtgt tcggcgcgac cgtcctgctc ccgacgctgc tcgccctcct cggcccgcgt
    13741 gtcgagggcg gccggatgcc gtggcggcgc cccacgtcca agcgcgcgca gcgcgaccac
    13801 gacagcggct tctggtaccg gctcggccac agcgtcatga agcacccgct gccgtacttc
    13861 gcggtcgtcc tggtgatcct cggcgtcatg ttcgggccgt tcctgcacgt ccagttcggc
    13921 agcatcgacg cccgcgtcct gccgaaggac agcgcgaccc gcgccgtcgt cgagaacgtc
    13981 aaggccgact tcccgaacgg caccgccgag cccatcgacg tcgtcatctc cggcgacctc
    14041 atcccgcgcg actggaagcc gtccaagtcg agcgacaaca tcccgcccta cctggagggc
    14101 ttccgcaaga agctcgccgc gctccccggc gtcaccgagg cgaagttcac cggctactcc
    14161 ggcgcgtacg gcggcgtccg catctccgtg acgcacaagt acgagccgat ggacgagcac
    14221 gcgcaggacc tcgtcaaacg gatccgcgcg atgagcctcg aaaaggacgg ctacccgatg
    14281 cacatcgacg tcgggggcag cacggccgcg cagatggacc tgatgtccag cctcatgcgc
    14341 agcctgccga agatggccgt cgccgtcggc gtcgccacgt tcatcctgct gttcatgttc
    14401 ttcggctcga tcgtgctgcc gctgaaggcc atcgtcatga acgtcctgtc gatcggggcg
    14461 tcgttcggcg cgatcgtgtg gggcttccag tacgggcacc tcgccgggat cctgaacttc
    14521 accccgaccg gcggcgtcga ggccaccagc atgatcctca tcctcgccgt cgtgttcggc
    14581 ctgtcgatgg actacgaggt cttcctgctc agccgcatcc gcgaggaatg ggaccgcacc
    14641 cacgacaacc gcgccgccgt cgcccgcggc atgcagcaca ccggcggcat catcaccagc
    14701 gccgcgctgc tgttcctcgt cgtcatcggc gcgttcagca tggccggcat caccgtcgtg
    14761 aagctgatcg gcgtcggcat gttcgtcgcg gtcgtcgtgg acgcggcgct cgtccggtcc
    14821 ctgctcgtcc ccgccaccat gcggttcatg ggcaaggcga actggtggct gcccgcgccg
    14881 ctggcgttcc tgcacgccaa gatggacctg cgcgagcaca gcgtcgccgg ggccggcgcc
    14941 ggaccggcgg ccgtggcggt gccgccgccc ctgccggagg cgcagccgtt cccgtaccgg
    15001 atgcactggg agcagggctc cgccgagacc cccgcaccgc ccgcggctcc tgcggcgccg
    15061 ccgccccccg ctcctccggc gcctccggct gctccgctga acgtgcacga cgcgttcaag
    15121 ccggccatgc agcccgccgg cgaacgcccg caactggtgt tccgcgaccc gagccccgcc
    15181 accgcggccc gtccggcgca ggcacagacg ccggcgccgc agccgcaggc gccgtgggcc
    15241 ccgtgggcca acggccggcc gcagccccgc cccgtccgtc ccccgcgggt caagcgccgg
    15301 atcgtcccgt cccccgacgg cagcggctgg acgtggagct ccgactgacc ctcagcgcag
    15361 cagcccggcg atgatctcgc gggcgcggcc cacgccgtcc tccgcccgga tccgccggcc
    15421 cacctcgtag gcgcggtccg ccatctcctg gtcctcggcg acccgccgca gctcccgcgc
    15481 gaggcgcggc accgtcatcg cgcggaacgg cagcggcgcc ggccccgcgc cgagcgccgc
    15541 gacccgctcg ccccagtacg gctggtcgcc gaagaacggg cacaccaccg tcggcacccc
    15601 gaaccgcagc cccgccgcgg tcgtccccgc gccgccgtgg tgcaccaccg ccgacatgcg
    15661 cgggaacagc cacgaatgcg ggacgtcccg caccgcgagg acctcgtcgt cggaggtggc
    15721 cgggtcgccc tgcaccacgc cgcggacgcc cgcgagccgc agcgccgccc gcacgatccg
    15781 cccggtcatc tccgcgtcct tcggcaccat gctcccgaac ccgacgtaga ccggcggcgg
    15841 acccgcggcc atgaacgcgg cgatctcctc cggcgggtcc cactccggct cgtccaggaa
    15901 ccagtacccg gtcatgtgca cgctcgccgg ccagtccttc ggacgcggca ccacggcctc
    15961 gctgaagcac gccagcaccg tcgtcccgtc ccgccgcagg ccccgcagcg gaagccgcgg
    16021 caggccgagc cgctcgtccc gccacgggtt gatgaacggc cgcgacagct gccacgcgat
    16081 ctggtcgacc gccccgaagc tcgcccggtt cgcccacggc ccgaacatcc gcgcctgcgg
    16141 cacgaacgga tgcgggaacg cccctgtcgg ccggctcggc tggaagtgga tcagcgcccg
    16201 cggcacgccg agatgctcgc cgatgtgctc cggcaggaac ccgagcgtcg gccccaggat
    16261 caggtcggcg cccttgcacg cgtccaggca ctcgcccagc agccgctcgg ccatcgggcc
    16321 gaggatccgc cggaacccgc cgaggaactt caccgggttc cgcccgccgg ccagcagctc
    16381 ctgccccgcg tccgactcca ggatctccgt cgggtccgcg gtcagcgccg cgagctccag
    16441 cccggccgcc accgccatcg gcgcgtaccg cgcgctcgcg accagccgga cctcgtcacc
    16501 ccgctcccgc agtgcccgcc cgagcgccac gcacggctgg atgtcccccc gcgatcccgc
    16561 ggcgaagatg acgattcggc tcacgaaagc tcctcaccag gcatcgctgc gcggacgcac
    16621 gtccggccca ccggccgggt cctcgtcctc gggcacatag ggcgcgtaca tccacccgtc
    16681 cggcggcggc ggaggccacc ccggcccccc gacctccggc acctcgtcgt cgtccggccc
    16741 ggcctccgcg cctccgcgcc cggccaccca cgcgtcccca ggctccccac ccgaaacccc
    16801 ccgcggccga tcatcggcgg ccggctcctc gcgagcctca ccctcccgaa gccccgccgc
    16861 ctccgattcc gcgccgcccc ccgccacacc accaagccca gagccccccg ccccaggcgc
    16921 ccccgcgacg ggcgtgatgg cgacgggcgt cgccgcggcg ggcgttgccg tgtcaggcgt
    16981 ccccgcctcg ggtgccatcg cgtcgggcac cgctgcctcg ggcgtcgctg cgtcgggtgc
    17041 cgccgcggaa ggtgttcccg ccatggggcc cgccgtgtcg ggtgtcaccg tctcgtgcat
    17101 tgccgccacg ggcgtcgtcg ctccgcctgc cccgccatca agttgttcgt ctagcggccg
    17161 gtcgcccagc gcgggcggcg cctcttcggc gtcctccagg ccgttcaccg ccgtggcgcc
    17221 gagcgggtcg gtgcccccca gtttcaacgt gacaggcggg ggcggtgcgg cgccgtgcgc
    17281 cgggtagggc gctccgacgt gctggtcgcc ggcgtggccg ggctcgcctt gggcggccgt
    17341 cgcggggcgc tcgtcgttga gcggctggga ggggggtgtc gtgctggggg cttcgctttg
    17401 aggcgccgcc gtttccggcg ggggcgatgt ggtgctgtgc ggggcctctg atgcggggta
    17461 aggcgtgccg gtgtgctggt cgctggcgtg gttcggctcg tcttgggtgg ccgtcgttgc
    17521 ggggcgctcg tcgttgtgcg actgggtggg gggcgtcgtg ctttcgcttt gaggtgtcgg
    17581 cgtttccggc ggttcggcgc tcggatgtgg tgttccgggg acgggtgccg gtagggcggt
    17641 gtgctcggcc tggccgatgg gctggtcttc gcccggccgg gcggggtcgt ccaggtcggc
    17701 ggcctcgggc gcttcctgcg gttctgggct gccggtgccg ggctggtgcg tggcggcggg
    17761 cggggagggc ttgggcttcg ggaggttctt gccgcgggac gcgaggtcct tgaggacggc
    17821 gtccgcgatg ggttccgagc cgggggcggg ggacgtgccg ccgggcgtcc agcggtcggg
    17881 gagggtggcg agggggtcgc cggagagggg gagggtgccg cgggagcggg cggcggactc
    17941 gtcgtcgaac cacttgctgg tgggcggcga aggctcgtcg tcgggggtgg tccaggtggg
    18001 gatggcggtg tcggcccagt cctgccaggg ggacgtcgcg tcgggcgggg tggggcgcca
    18061 ggtggcgggc gcgtcgtcgt cgggggtgtc gctccaccag tgcgggccgg gggtgcgggg
    18121 tgcggccatg gtctccgttt ccgtcctgaa ggggaggggg gcggggacgg gctcggcgga
    18181 cggggcggcg ccggcggggt cgggggcggg gacgacgggg agcgggtcgc ggggggtcgc
    18241 ggtgacggcc gcggcggcgg tggcgagggc cggtgcgggg gcggcggcgg gttcggcgat
    18301 gaggggcgcc tgcttgccgt gcttggggcc gagccagccg cgccggctgg gcagggtgag
    18361 ggcgctgatg acgccgccga tgaggacgag cccggcgccg agggcgaggc cggaggaggt
    18421 gccctgccgg aaggactcga gggccttggt gctcgcgctc tcgtccggga tggtgtggac
    18481 gaggaggccg acgatggcga tgccgaacgc gccggacgcc tcgcggatga cgttgatgac
    18541 gccgctggcg acgccggcgc gcttctcggg gacggccttg aggacgtaca tgacgagggg
    18601 catggcgagg gcggcgccga cgccgacgag gaggacgccc ggcatcaggt cggcgtagcc
    18661 gtcgccgatc tggagggtgg agaacagcag catgccgacg cccatgaggg ccattccggc
    18721 gccgatggcg gggcgggggc cgagcttggt ggcgagcagg aacgcgacgg gcgtcagcac
    18781 catgatggtg agggcggggg gcagcatgac gaggccggcc tcgggcgggg agaagccgag
    18841 gaagcgctgc aggaacggct gcgagtagaa catcatgccg ttgaagccga tgccgtagag
    18901 catctgcgag accagcccgc cggtgaagac gcggttgcgg aagaaccgca gatcgatcat
    18961 cggttcgggg gcccagctct cgacgacgat gaagcagacg agggcgatgg cgccgagggc
    19021 gaaggtgctg aggacggacg ggtcggtcca gccgtgcttg ttgccgtcct cgaggccgta
    19081 gatgaaggcg aacagcatcg tcgcggagat cagcacgccg ggcaggtcga tgcgggcgcg
    19141 ccggttcttg ccgcggccgg tgaggacgac ggcgccgagc aggatgacga ggatgccggg
    19201 gacgatgttg atgaggaaga tccagcccca gtggaagtgc tcgacgatga tgccgccgat
    19261 ggtggggccg agcgcggtgg cgctggacgc ggcgccgatg aagacgatgt tgccgatgga
    19321 gcgctgcttg tcgttgcgcc cgacggtgac catgacctgg gtggcgggca ggacgagcgc
    19381 ggcgccgccg ccctggacga tgcgggcgag gatgaggatc tcggagccgt gggcgaggcc
    19441 gcagacggcg gaggcggcgg tgaagacggt catgccggtg gtgaaggtga cgcggcagcc
    19501 gtagatgtcg gtgagccgcc cgccggtgat catcaggcag gagaacatca ggatgtagcc
    19561 ggtggcgacc cagtccttgg cggaggacga catgccgagg tcggccatga tcctgggcag
    19621 cgcggtgaag accaccgtgt tgtccatggt ggtcatgaac gcgctgacgg ccaccaccgc
    19681 cagcgcccat cggtatcggc cgcgggtcac ctgatcctgc ggcggggtcc cgtgccgccg
    19741 ggaaatccgc cgcttccccc taaaagcgtt cgtggctatt gttactattg gttggcatcc
    19801 ggtcactcgg cccgctgtta ggccagagtc cctcaactat cccatcaggc cacattggtt
    19861 actgccgagt cttgtcatca ccgtgacaag tagcggggga gaaaagtggt ctggatgcgc
    19921 atcgtgagcc ggtcaccgta ggacaaagtg gtccctccgc ttcgatgaac gatcccggtt
    19981 tcatgggggg aacccaccgc atgcagagca acgatcgttc cggagccgcg cgggacaacg
    20041 cggagggcga gccgcggatc ggtgaggacg cgattcgccg gcacctggtc gagcagatcg
    20101 cgcgccgctc ccggatcgcc gaggccgagg tcgacccgga ccgcccgctc gaggagttcg
    20161 ggctggcgtc gcgggacgcg gtggcgatcg cgggggatct cgagcagatg ctgggccggg
    20221 cgcttccggc gacgctggtg tgggagcacc cgacgatcag caagctgtcc cgggcgctgg
    20281 cgggcggagc gggcgcggcc gaggcggagg cggagcgggc ggcggcgccg gtccgggcgg
    20341 tggtgcggga ggacgagccg atcgcggtgg tcgggatcgg ctgccggttc ccgggcggcg
    20401 accgcgacct gacggggccg gcggagtact ggcggttcct gacgggccgg ggcgacgcga
    20461 tccgggaggt gccggacggc cgctgggacc cgttcgacga cggttccccg gaggtcgcgg
    20521 accggctggc gcggacgacg cggctcggcg ggttcctgga cgacgtggcg gagttcgacg
    20581 cgcagttctt cgggatcacg ccgcgcgagg cggcggtgat ggacccgcag cagcggctcg
    20641 tcctcgaggt ggcgtgggag gcgttcgagc acgcggggat cggcccggcg tcgctgcgcg
    20701 gcagccgcac cggggtgttc gtgggggtgt cggcgccgga gtacgcggcg ttcaccgcgt
    20761 cggacctggc gtcgctggag ccgttcacgg cgacgggcgc ggcgctgagc atcatcgcga
    20821 accggctgtc gtacctgctg gacctgcgcg gcccgagcat gatcgtggac acggcgtgct
    20881 cgtcgtcgct ggtgtcgacg catctggcgg tgcaggcgct gcgcagcggc gaggcggacg
    20941 tggcgctggc gggcggcgtg aacgtgctgc tgtcgccgac ggtgacgatg acgttcgacc
    21001 tggcggacgc gacggcgaag gacgggcact gcaaggcgtt cgacgcgtcg gcggacggga
    21061 tggtccgcgc ggagggctgc ggcgcggtgg tgctgaagcg gctgtcggac gcggtccgcg
    21121 acggcgaccg ggtcctcgcg gtggtcaagg ggtcgggcgt caattcggac ggccggtcca
    21181 acggcctggt ggcgccgaac tcggacgcgc agcgggcgct gctgcgggac gtgtacgcgg
    21241 cggcgggcgt ggagaccggc gaggtcgact acatcgaggc gcacgggacg gggacgttcc
    21301 tgggcgaccc gatcgaggcg aaggccgtcg gggaggtgct gggcgcgggc cgggcggagg
    21361 atgagccgct gctgatcggg tcggcgaaga gcaatctcgg ccacatggag tcggcggcgg
    21421 gcatcgcggg cctgatcaag acggttctgg cgctgcacca caaggtgatc ccggcgagcg
    21481 cgcactacaa ggagccgaac ccgcacatcc cgttcgacga gctgcggctg aaggtggtcg
    21541 cggacgagac gccgtggccg gagcggagcc atcccgcgcg cgcgggcgtg tcggggttcg
    21601 ggttcggcgg gacgaacgcg catgtgctgc tggaggaggc tccggcgcag gagttcgcgt
    21661 cccagccggc ggtgatccgg acgttcccgc tgtcggacac ggccgacgac cgcgtccgcg
    21721 accatgccgc gctgctggcg gcctgggcgg cggaccgcga tgacgtaaag ctcgccgacg
    21781 tggcgcggac gctgcaccgg cgcggcgggc ggggccgggc gcgcgcggcg gtgtcggccc
    21841 gggaccgcgc gggcctggtc gagggcttga aggcgctcgc ggagggccgt ccgcatccgg
    21901 gcgtggtgac gggttcggcg ctcggtgtcc cgggacgccc ggtctgggtg ttctccgggt
    21961 acggggcgca gcgcgcgggc atggcgcagc ggctgctgga ggaggagccg gcgttcgccg
    22021 aggcgatcga cgacctcgac ggcctgttcg ccgaggaggg cggccccgac ctgtggtcgc
    22081 tgctggagga gggccgcaag ccggacggcc cggccgacac gatgccggtg ctgttcgcga
    22141 tccagctcgg cctggcgcgg atgtggaagg cgtacggcgt cgtgccgggc gcggtgatcg
    22201 ggcattcgat gggcgaggtc gcggcggcgg tcgtcgcggg cgcgctcacc ccgcaggacg
    22261 gcgtccgggt gatcgtgcgc cggtcgaggc tgctgacgca gctggtcggt ggcggcgcga
    22321 tggcggtgct cggcgcgtcc gcgcaggagg tcgagcggct ggcggacggc ctgcccgagg
    22381 tgtacgcggc ggtgcactcg tcgccgaagc agacggtcgt gacgggcgac gccgaccagg
    22441 tggccgagat cgtcaagcgc gcggaggcgg agggacgcct cgcccggatg atccaggcgg
    22501 agggcgcggg ccactccccg caggtcgatc cgctgctgcc ggacctgcgc gaacagctcg
    22561 ccgaggtcgg tctcgaaccc ggcacgccgc tcgccgacgg catcaggctc tacacgacgg
    22621 cgctgcccga cccgcgcgcg ttcgacggcg acggcgcccg cctggacgtc gagtactggg
    22681 cggcgaacct gcgcaacccg gtccggctga cggacgcggt gtcggcggcg gccgaggacg
    22741 ggttccggac gttcgtcgaa atcaacgcgc acccgatcct cgcgcacgcg gtcggcgaga
    22801 cgctcggcgg cagcggcgcc ctggtcacgc acacgctgaa gcgcgcgccg aagggccagg
    22861 agaccgacga cacgctgacg ttccacgcgc agctcgcgac gctcgccgcg cacggactcg
    22921 ccgttgcaca gcctgtggac ggacggatcg tcgacgtccc gcagtcgccg tggcggcacg
    22981 agcgccactg ggtcgacctg tcgtcgcgca accgcggcgg ccgcgacgag cacccgctgc
    23041 tcggcgcgca cgtcgaactg cccggcgagg accggcacgc ctggcgcgcc gacgtcggcc
    23101 tggacgcgca gccctggctg aacgacctga ccgtgcacgg gctgcacgcg ctgcccgtcg
    23161 ccgcgttcgc ggagatggcg ctcgcggcgg gcgcggaggc gctcggcacg gacgccgtcc
    23221 gtgtcaacag cctgtggata gagcgcccgc tcgcgctcgc cgagcacacg acggtgacga
    23281 cgacgttcgc cgaggcggag cagcgcgtcg aggtgcacgc gcagacgccc gcgggcacgt
    23341 gggcgcggct ggccagcgcg gacgtcggcg aggacacccg tcccgccccc gcgcccgagc
    23401 ccggtgcggc gaccgaggtc gcgggcgccg aacgcgggtc gcggcactac cggctgcatc
    23461 ccgaggtgtt cgaccgctgc ctcgccgcgc tgtcggcgga ggccgcggcg gtcgcgggcg
    23521 gcggcgtctg gctcgccgag acgatcggga gcctgcgcgt gcacggcccg gcgcaccgcg
    23581 gcgggcacgt ccgcgcggcg gtcgccgagg acggcggcga gctgaccggt tccgtcctgc
    23641 tgctcgacgc ggacggcggc gtcctggtgg aggcgagcgg catcgtgctg cgccgcaccg
    23701 aacgccacga cgtgcccgtc cccgtcgccg acaagctggt cgagctggtc tgggacgagg
    23761 ccgacgcctc cgagcccggc gacggcgacg gcacctggct gatcctcgcc gaggacggcg
    23821 acgcgctcgc cgcggccacg gccgccggcc tgggggagcg cggccgccgc gtcacccgcc
    23881 gcggcttcgc cgaggtgggc gacgcctccg gggcggaggg cgtcgtgctc gtcccgtccg
    23941 ccgacctcgt cgacgaggac ctcgtgctcg ccatcgcgga cgtgagccgc tcgctgcccg
    24001 acggcccgcg cctgtacatc gcgacgcacc gcgccgtccc cgtcctcgac ggggaggcgg
    24061 gcgagcccgg gcacgggttc gccgccgcgc tgacccgtgt cctggcgttc gagcggaccg
    24121 tccagcgggc gacgctcgtc gacgtggacc gtcccacgga cctggtcgcc gagctgctcg
    24181 gcggcgacgg cgcccgcgag gtcgcccggc gcggcggccg ccggtacgtc gcgcgcctcg
    24241 cccaggccgc cctgccggag gcgaaggcga agaggatcgt ccggcgcggc ggcgcctaca
    24301 tcatcaccgg cgggtacggc gggatcggcc tggtcaccgc gcggcttctg gccgagcgcg
    24361 gcgccggccg gatcgtcctg tccggccgga gcggccccgg agccgacgcc gagaaggtga
    24421 tcgcgaagct gcgcgagggc ggcgtggacg tcggcgtcgt cctcggcgac atcgccgcgc
    24481 ccggcaccgc cgaacgcctc gtgaaggtcg cgcaggaggg cggcgtgcgg ctgtgcggcg
    24541 tcgtgcacgg cgccggcgcg atcgacgacc ggctgatcgc cgacctcggc gccgaggatc
    24601 tccacagggt gtggacggcg aaggtcgagg gcgcgcggcg gctcagcgac gccacctggg
    24661 acctcggtct cgactggttc gccgtgcact cgtcggcggc ggcgctgctc ggctcgcccg
    24721 gccaggccgc gtacgccgcg gcgaacgcgg cgatcgacgc gctcaccgcc taccggcgcg
    24781 cgcacggccg tcccggcacc acgatcaact ggggcacatg gtcgcgcgtc ggcggcgccg
    24841 ccgagaccgc ggtcaccgtc atcgacccga tcagccccga ggagggcgcc gaagccctcg
    24901 aagcgctcct cgcgcacggc atgaccgcga cgggcgtgct gcggttcgac ccggtcacgg
    24961 ccgtcgagct gttccccgag atccggaaca tgccgtactt cgcggcgctg accgaggcgg
    25021 cggccgagcg cggcgccgac gacgccggcg actggcccgg cgtcgacgcc ctcaaggaac
    25081 tcgacccggc cgaggcccgc acgctgatcg ccgcgcagat ccggtaccgg atcgcgtccg
    25141 tcctcgggtt cgaccccgag cgcctcgacc cggccgtccc gctcaccgac ctcggcctgg
    25201 actccctcgt cgccgtccgg atcaagagcg gcgtcgagca cgacctcggc ctcaccgtcc
    25261 cgcccgccgt gctgctgcag ggcgcgagcg tgaacgtgtt cgaggagtgg gcgtccggcg
    25321 agctcggcct cgccgacgcc gccgccccca ccgccgtgtc gaacgccgag tccggctacg
    25381 tgatgccccg cgacgccgcc gagcgcctcg ccgtccgcat cttcgaggac gtcctcggcc
    25441 tcgaccgcgt cggcgtcacc gccgacttct tcgccgacct cggcggccgg gagcaccagg
    25501 ccgaccaggt cgtcgcgatg gtcgccgccg agctcggcgg cgaggtcacc cgcggcgagc
    25561 tgttcgcggt gccgaccgcc gagaacgtcg ccgaggtcct gcgggccgcc gacgaggagg
    25621 ccgcgcggca gaccgtccgg ccgctcaagc cgtccgggga ccgccgcccg atcttcatcg
    25681 cgcaccccgc cggcggcacc accgcctgct accggcagct catcgacctg ctcggcgacg
    25741 accagcccgt ctacggcctc gagcggttcg aggacgcgcc gcccgtcgag gagcgcgccg
    25801 cccgctacgt ccagcacctg ctggaggcgc agcccgaggg cgcgttccgg ctcggcggct
    25861 ggtcgttcgg cggcgtcctc gcctacgaga ccgcccggca gctccgggcg gccggacgcg
    25921 aggtcgagtt cgtcgcgctg ttcgacgcgg gcatccccct cccggtggac gacgagtccg
    25981 acaccctcgc ccgccggttc tccgcgttcg ccgactacat caacgagacg tacggcctgg
    26041 acgtcacgct cacctacgac gagctgtccg ggctggacga ggaggcgcag ttcgcgctgg
    26101 tcatggagcg ggcggcgccg ctggtggact acatcccgcc ggcggccctc acccaccagc
    26161 tcacgtccca ccaggacacc cgatccctgg aggcgtacca gcccggcacc tacgacggcc
    26221 gcgtcgtcct ctactacgcg cccgaagaga ccccctgggc ggtgcgcgac gcgcgctacg
    26281 tgctcgacgg gaccaacggt ttcggcgggc tctgctccga cctggagatc gtcacgatcc
    26341 ccggggtgca ccacctgaac ctgctggacc cgccgggcgt ggagattctc gccgcgcacc
    26401 tggagggccg gctcgccgga cgcgcccccg ccgcggacgg tgcgaaccgg cggcccgcgg
    26461 acggcccgga cgcgcgcgac gcgtccggcc gcgcccgggc cgcggcacgg tcgaccatgg
    26521 cccgctgagg gccgcgcccc caccccgtcg ttccacggag gacacccatg gccaacgaac
    26581 tgctcgacgc cgtccgctcc ggagcgagcg gacccgagct gcaggacatc gacctgccgt
    26641 cccggttccg cgccgcgttc acccgcaagg acgaggtcgg catcttcgac ggccaggccg
    26701 acaaggacgt gcggaggtcg ctgcacgtcg gcgaggtcga catgcccgag ctggcgcccg
    26761 acgagtgcgt ggtcgcggtg atggcggccg cgatcaactt caacaccgtc tggtccgcga
    26821 tcttcgagcc ggtgccgacg ttcgcgttcc tggagaagtt cggccggcag ggctggtacg
    26881 gcgcccgcca cgacctgccg taccacatcc tcggctccga cggcgcgggc gtcgtcgtcc
    26941 gcaccggcgc cggcgtgaag aactggaagg tcggcgacaa ggtcgtgctg tccccgtcct
    27001 acgtggacga ggaggaccac ggctcctacg acgacggcat gatgtcggag tcgcagctcg
    27061 cctggggctt cgagaccaac ttcgggtcgc tcggcgagta ctgcatcgtc aaggcgaacc
    27121 agctcatcaa gaagcccgcg cacctcacct gggaggaggc gggctccaac acgctgtgcg
    27181 ccggcacggc gtaccggatg ctcgtcggcc cgcacggcgc ccgcatgaag cagggcgacg
    27241 tcgtgctgat ctggggcgcg accggcgggc tcggctcgtt cgcgacgcag ctggtcaaga
    27301 acggcggcgg catcccggtc ggcgtggtct cctccgagga gaaggcggag atcgtccggg
    27361 cgcagggctg cgagcacgtc atcaaccgca acgagctgaa cctcggcgag cagggcctgc
    27421 ggcacccgaa ggcgggccgg atgctcggcg aggcgatccg cggcctcgtc ggcgaggacc
    27481 ccggcatcgt gttcgagtac ctcggccgcg agacgttcgg cgcgtccgtc tacgtcgcca
    27541 agcgcggcgg caagatcgtc acctgcggct cgtcgaccgg ctacaagcac gagtacgaca
    27601 accggttcct gtggatgcgg ctgaagagca tcatcggctc gcacggcttc aactaccacg
    27661 aggccgtcga ggtgaaccgg ctgttctccc tcggcatgat ccacccgacg ctgtcctcgg
    27721 tgttcccgct ggacgaggcg ggcgaggcga cccgcgccgt gcagacgaac cagcacatcg
    27781 gcaaggtcgc cgtcctctgc ggcgccaccg gcgagggcca gggcgtcgac gacccggcgc
    27841 tgcgcgagcg catcggcgag gacaagttca acctgtaccg ccgctgacca cccccggaac
    27901 ggccccccgc gtgcaccgcg cgggggccgt ttcgttctgg tccggggcgg ttcggaggtt
    27961 catgatggcg gagtgacctt caggggtggg cgccggcggg gcgcgcgcga ggaagccgcc
    28021 cgtttcgaga cccggctgac ggcgttcggc gaactgctcg ccggtcaccc gttctcggcc
    28081 gaccgcctcg acgcgacgca cgagatggcg gtcgagtacg cgcgcgccct cgacgcctac
    28141 gaggccgcca agcgcgcggc gtcccgcgac ccggcactgg ccgggcggga actcgccgcg
    28201 ggactggcgg cgctgaaccg cctcaacacc cacctcgtcg gcaccgcagc gcccgaggct
    28261 ccggcgaagc cgaaggcccg gcgcccggaa ccgcaggtgc tggaagtgga ggccgaggcc
    28321 acaccggtcg aggcggacca cggggaccgg aggccgagcc cgggcgaccg cgcaaggcgg
    28381 cccggcctgc gcgaccgcta cacctcagtg cagctcgcga agcggacggg cctcacggtc
    28441 gcggccgtct atctcctcgt catcgccctc ctgggctcct ggtggctggc gttcgtcggt
    28501 ctgatggccc tgacgatggg tggcgggctg gccgtgttcg gcggcttcct gggatgggca
    28561 tcggcgtccc agctcgtggg caccgtcaga gggggactgg tcagcgccga gtacctccgc
    28621 accaccaaga aggtctcgta cggcctgcgc gatgctccct accagcactt ctacgtgtac
    28681 gtgggcgacg acggcgagaa ggtgacctac cagcgcgacg cggtgagccg gtcccttgcg
    28741 gtcttgccga cccggcggct ctggctggtg aagggcggcg gccggaccgg tatggagacc
    28801 cacctgagcg ccctctgggc aacgccgctg tcgttcgtcc ttctcgacct cgccgtgcct
    28861 ctgttcctgt ccggtacggc catcgtcctg tacacgtgcc cgggcctgct gatccgggtg
    28921 ctggccggtt gacgcggggg acgggaacgc ccgcccgtcc gcggatgcgg acgggcgggc
    28981 gcgctcgtca ggacgcggtc atcctggcgt agacgatcag gttctcggtg tagtggccgg
    29041 ccttcgggtc gaaggcgccg ccgcacgtca ccaggcgcag cgccgggtgg tccagcgact
    29101 cgccgaagac cttctggtgc gggaacgcgt ccttgttgac gctctgcgag cgttccacgg
    29161 tgaacgtggc ggtcgtcccg tccttgcggc cgacctggat cttgtcgccc ggcttcagct
    29221 ccttgagccg gaagaacacc gcggccttct tgttcgcgtc gacgtgcccg aggatcaccg
    29281 cgggcccgac ctcacccggc gtcggcccct ccttgtacca gcccgccagg ttcggccggc
    29341 tgagcggcgg ctcctcgatc cgcccgtccg gcttcagccc gatctgcccg accggcgcgg
    29401 acaccccgat cctcgggacc gtgatcttga cgggctcgga cggggcgagc gacgagacgt
    29461 tcgacgcggc cgtggtgccg cccggcgtcc cgctcgccgc gggcgccggc gacgacgagg
    29521 acgccgcctt cccgcccccg cctccacagc cgccgagcag cagtccggtg agcagcgcgc
    29581 cggccgccgc ggcctggagg cggcggcggc cggcggtccg tgcggaggac tcaggcaacg
    29641 gtcgaccgct cccgcgccgt ccggcggcgc agcgcgacgg cgccgagccc ggcggccgcg
    29701 agcgcgcccc agccgatcgc cagcagcggc gcgccggagc ccgccgccgg gcggtacatg
    29761 ctgccgtcgc cggtgtcgat ccgcccgttc gggatcttcg gcgtggtcgg ctgcatgctg
    29821 ttgccgccct tggaggggtt cttggacggg tgcgtgctgt acttcaccga cccgaagccc
    29881 ttgcagacca ccgtcgcgac cgtcgggtcc ggcaggctgc tcttgaacgt gccgctcgcc
    29941 gtccaggtgg ccttgccggt cttgcgcacc ggcagcgggt tgcgggtgta gccgttgctc
    30001 gtgatggtca ccgcgctggg gcagctcacc gtgaacgtcg tgtgccgccc gggcgccacg
    30061 acgcggctcg acagccgcac cttgtcgaac ccgaaccgga acaccggctt cggcgtggtc
    30121 ggcggcagcg gcttgtgcgt cgtggggggc gtcgggccct tgccggactt ccagcggagc
    30181 tttccgtcgg agcccggcgc gcagaccatg ggcgtgccct tggccgtctt gcccgtcgcg
    30241 ccggcgggag agcagaaggc gccggggtgg accgggccgg gagagtcggc gagtacggga
    30301 cccgccatcc cgagcaccag ggccccggtg gcgaccgccg ccgccgacag ccgagttgcg
    30361 cgcattggct tactcctctg ttcggggggg actcgccgtg cgtcccgggc tgggctcgca
    30421 ccttggccgg tggcggggga agccgcggga acgcgcggct tgcagaggcg ggtgcgctcg
    30481 tggttcgagg cccggtgtgc cggacgagaa cgatgggcct ggagtttagc gggatcaatc
    30541 accgcacaac cggaatgcga tggaaacatt ggctgactgg ccaattccgg aaacttgcgc
    30601 gaatggtgta aacctgcgac gacccctacg cgaccttccc atcgtcccag ctcatcccgg
    30661 ccgccaccgg accaatcaag atctttaagc gcccgatgcc gttgacgacc gtgcggcgtt
    30721 gtccggtgtg aagggaagat cgcgaacgta ccggtcgagt cgcgttccgt ccgcgccggt
    30781 ggcgtacccg gcggaagcga acccggccct ccgggcgacg gcgacggacg cgcagttctc
    30841 cggctccacc tggatcaccg cctgccgccc gcccgcggtc gccgcgtacc cgcaggccag
    30901 gagcaccgca cgcgtggcga gcccgcgtcc ccgccacgcc ggatagatgc cgtaggcgac
    30961 gttcacctgg ccggcgccca ggccctccgc ctcgaaccgc agatcgaccg tccccgcgag
    31021 cgtcccggcg gagccggccc ggatgccgaa agcgcggagc gacccaccgg tgtcccactg
    31081 ctcctggcag tgccggatgt aggcgtcaac gtcgccgcgc gtgctccggc ccccgctgag
    31141 ccaccggacc atcggctcgt cctcgcccgc cagatgcgcc tccgcgtcct ccggacgcaa
    31201 cggggccagg ctgatgaccc cgtcggacag ttccacgtca cccacccggc gattctgaac
    31261 cgccgggccc ccaccacgcc atccgataaa cgcccagctc cgtgcgggac ggccacggcg
    31321 gcgagatccc gggcccgcgc cggtgagccg ggggcgccca ccggccgggc ccctccgatg
    31381 accggatccg gccgttcatc ggaagctcct aatgcgcccc tgcgcgcgcg ccgcctcctt
    31441 tagcaactcg gtacgcagtt cctctatgca cgccctcatc gccgtcgcgt cgactcctgc
    31501 gcgcgcgtct aggagcgtcg ccacgtattc accgggcatc ccgtcccacc ggcgcgaacg
    31561 ccatatgcgg tgcccaggga attcctgtcg aaggcgctcg atagccgcgt catctggttt
    31621 cgattttctg tcttccacgg aaggtcccat gcgcggattc gcgggcgatg aatgtgttat
    31681 aagactcaca gaagcgcgcc gcctcccgcc ggcaatcact ccccgggaag gcgcaacccc
    31741 ccgaaagatc aaccaaaccc ggagccgggt ttcaggagga gatcccatga gctcgcgcaa
    31801 cgaaccatat gaagcccccg caattcaggc gttcgcctcg gagttgacgg cctggcgaga
    31861 aaaggccggc ctcagcaaga cggccctggc cgagaccctc ggctacaccc cgcagtggat
    31921 ctgccaggtc gaggccgcca agagcatccc gtccaaggac ttcgccgaga acctcgacac
    31981 ctacttcaag accaacggcg tcttcgagcg ccagcagaag cgcatcatcg agacccgcca
    32041 catggccatc ctcccgcccg gcttcaccga gtaccagcaa cgcgaagccg aagcgagcca
    32101 gattcggacg ttcgaactag ggttggtcca cggcctgctc cagtccgagg gctacatccg
    32161 cgcggttgtc ggttacgacc aagaggcgga gaccgtcgag cgtctcgtcg ccgagcgcct
    32221 caagcgacaa gagatcctca cgcgcgagaa cccgcccaac gcatcgttca ccctcgatga
    32281 gagcgcactg cgccgcgaga tcggtgggcc tggcgtcatg cgcgagcaac tggcgcacat
    32341 actcgctctg ggggaacgcg ccaacgtatc gatcgacgtg gtcccattta acacaggcta
    32401 ttatcctggc ctcattggaa gtttcaccat tctcagcttt tctggtgcgc cggacgtcgt
    32461 ttacggcgag atatcggggc ggggagtcct cttgcaagag ccgaccatcg tctctcgctt
    32521 cgcggtaaga tacaactcgc tgcgaggtga ggcactccgc gttcgagaat cgcggacgct
    32581 gatcaaaagc gtcatggagg agtacggatg accaagccgg atctctcgac cgcgaagtgg
    32641 cgcaaatcaa gccacagcgg ccacgatggt ggcaactgca tcgaggtcgc caatatctcg
    32701 ccggtcgtgg cagtacgtga ttccaaggac ccggacggcc cgaagctcgc gttcggcgcg
    32761 tccgcctggc gggccttcgc cgagcgcatc aaggctgacg cccacgacct gccctgacga
    32821 gacccgcaac gcacgaggga gcccccgccc gcatcgaccg gacgggggct cgccacgaac
    32881 ggacgtcttg atggcaatga tcagcgagca cggtcctgca tggacttaca tcgactacca
    32941 ccagttcttc ctgacggagc cggagcagtt ggacttcgtg gcggaggaag tcggcgacct
    33001 catctccgcg accggtgaat cggtcatcgt ccacacaggg atcgccaatg gccatgtggc
    33061 ggtgcacgtc caggtccatg acgatgagcc ccctttggat gaggcgggct gggaggaaat
    33121 cgccgaagcc gccgtccagg tggagaacgg cccgctcatg gtgcggtgcc tgatggagga
    33181 cgcgcccgac ctcccggccc tcacttccgg cccaggggac tacagggtcc gcgcgcacgc
    33241 tcgtggtcgc ggcatcgcct acgacgcgtg cgtccaccgt tcacaagagg tctacctgtt
    33301 ccaggtctgg cccgcgccgt acctgccgct gcacgtcctc gagcacaccg accatgagca
    33361 gcaaaggccg gcgccgcagc cctgcggagc agcctgcgcc cgtccagctc gcggtcggct
    33421 gtttcgagca cgtcccacct gagccgggaa ctcccattgc gatcgtgatc gggatgcgtc
    33481 gtcaggcggc gtcggtgaac tccaccttga gcttggcgtc gagggcatga gcgagcctct
    33541 cgaggacgcc gatggtcggt gtcgggccac ccgactccaa gcgggacagg gcgggctgag
    33601 tcatccccgc cctcctggcg agctccgact gtgtcaagcc cagcgccaga cgtcgctgcc
    33661 gaaccgcgtt gcccagttcg aacgccagac gggcttcctc ccggcccgcg cgcacctcat
    33721 cgctgtcacg gccggtacca ggctcccagc gatagtgagg gctgtgttca ttcacgcgtc
    33781 acacctccct gatgtagttc cgccgcgcgt gagcgtgttc ggcttcgcac tgtttacgtg
    33841 ctcgcatggc ccgttcgacc tcggcgccct cgcgttcctt ggtcttgtgg aacaccgtga
    33901 gcaggacgac ccgacgatcg gacgcgagcc agtaggtgat gcggacttca tgcggatgca
    33961 ggtggatgcg gagttcccgc agcccgtcgc cgagatgccg cgaccatggc tcccccaaag
    34021 tctcggcatt ctctgcgagg agcccgacga accagtccac gcgaccgaat tcacgatcgg
    34081 gtagtgaatc aagccactcg cggacctcgg gctcgatctc gacaccgtac agctccatgc
    34141 atcgaacgct atatgcatcc aacggtatca ggcggcggct ttggcggcca ggatgccgcg
    34201 aaccgtcggc gccatggatg gcaagcccgg cgcggcggac atgctggacg aagggccctc
    34261 tcgccggcca tggtccccgg ggctggaccg tcagtgcagg ccgaagtgtg cggcctgggc
    34321 ggtcacggtg gcgggggcgg cgttggcgcc gcacagcacc aggcccagcc gggcgccgtc
    34381 gccgacccgg tcgaggaccc gccgggcggc ggggagcagg cagccggccg ccggctcggt
    34441 ccaggccttc gcgtgctcgg cgaggtcgag gacgccctgc acggcctccg cgtctgacac
    34501 caccaagacc tcgttgacca gcgcagacac gtgctcgtag gtcagctggg agactgccgg
    34561 cgggctcagc gtggacacga tggacgacaa cgcgacgggc accggtccct gggcggcgag
    34621 cgccgcggac atcgtctcgg ccccttcggt ctcgactccc cagacccgca cgcccggccg
    34681 ccgcgcccgc agcgccgcgg ccaccccgga gatcagcccg ccgccgccga tgctgaccag
    34741 cacgtcggtc agctcgccgg cgtcctcggc cagttcgagc ccgaccgtgc cctgacctgc
    34801 gatgacgtcc ggatcgtcga acgggtgcac gaccgtcatg ccctcgcctt ggagccgctc
    34861 catcagcgcg aacgcggcgt ccacggtgtc ggccagccgg accgcggccc cggcggactc
    34921 ggcgatctcg acggcgcgcg ccggggccga ccgcggcatg acgacggtcg ccttgacgtc
    34981 gagcgcggcg gccatcaccg cgaccgcgat cgcatggttg ccgccgctca ccgccaccac
    35041 gcccgccgcg cgttcggcct cgccgagccc gagcagcttg gcggtggctc cccgcgcctt
    35101 gaaggacccg gtgcgctgca gcatctccag cttgaccgtg acggggacgc cgagcagatc
    35161 ggacagcccg gggctcggca ccgtcggtgt gcggacgacg tgaccggcga tcagctcggc
    35221 cgccgcctcg atctctccga caccgatcac cacggccacc tttcgccata ccgtcctggc
    35281 cgcacgcaaa cctacacagc gtccgggtgc gggttcttgg cggtggccgc tatgacggct
    35341 cgggagccga gagtgacggt ccgcgcgccg gcgtcggtga agccggcgga cgtggcgagg
    35401 gagcatgcct gttcggcgtc ctccggcaga ggcaggtctt gcgcgacgag ctcggcgaag
    35461 acgcccgacg ggcggaaccg ggacgccacc ggcagcgtga agccgatccg gccgccggga
    35521 cgcagggcgc ggcgccagtc ggccagggcg cgcatgccca ggaagtggag cgaggaggcg
    35581 cacaggatca ggtcgaggga ggagtcgggg accggcagcg ggacggccgg tgccgcgcgc
    35641 cagtcgatcg cgccggcgca gccctgccgc gcggcccggg ccctgccgac cgcgatcatg
    35701 tccggggaca ggtccaccgc gaggacggcc ggcgccgggc cgggcggccg cgccgcgacc
    35761 tgcagggcga ccgcgccggc gccgcaggcc acgtcggcca ccgcgtcccc gggggcgggc
    35821 ggcgcgagtt cgagcagggc gcgcgcgacg gcgtcgtggt gatcgtggtc gtacgcgccg
    35881 gccagctcgc cgaacgcctc ggccatccgc acggaatcgc tcatgatcga acgctagccc
    35941 gccgtggacg tccgcgcggc cgtccgccgg cggccgagcg ggcccggagg cctgatgaga
    36001 tcgtcatccg gcgggggcgg cctcggcggc gacggcgagg aggtcccggg cgccggccga
    36061 gagggcttcg gcgaagtcgg tctcctcgtc ggccgtccac cgttcggtcg ccaggcggag
    36121 gacggcgagg ccggcgtcgg tggcgagccg cgccgactgc ggttcgcagc cgcggcgcac
    36181 cagggcggcg gtgagggcct cggagagcgc gacgagcttg atcagctcgc gttcgcgcaa
    36241 cggcgggctg gccgcgatga ccgccgcccg cctctccagg aagtcgcggg ggcggaacac
    36301 ctccggcgcg gtggcgaacg cggccaggag cgccgggagc gcgccggtgc ccgccgggac
    36361 ggcgtccagc gcggcgagga accgctgctc gaggtcgtcg cccgcgaaca gtacctcgcg
    36421 cttgtcggcg aaccaccggt agaaggagcg ctcggtgagg ttcgcgcgcc gcgctatctg
    36481 cgccacggtc gtgcggtcgt agccctgctc ggcgaacagg tcgagcgccg cccgctcgag
    36541 gcggctccgc gtgttcccct cccagcgtgc catgcccgcg agtatagcga cagcagatgc
    36601 tgtcatcact ctgctagcgt ggaagtgatg acagcatctg ctgtcacttg ttctggggag
    36661 gttccatgcg cacccttcgc ttccatgagc acggagcacc gctcgacgtc ctgaggctcg
    36721 aggacgccga gccgcccgag cccgcctccg gaatggtccg ggtgcgggtc gaggcctgcg
    36781 ggctgacccc cgcggactgg gcgctgtgcg gcgggctctt ccccggcgac ctgccacgcg
    36841 gcatcgggct ggaggtcgcc ggcaccgtcg acgcggtcgg cgacggcgtg accggtgtcg
    36901 ggatcggcga tccggtgttc ggcccggcgc ccttcaccgg gccgaccgcc ggcgcctccg
    36961 agcaggcggt cctcgagatg tggttcccgc gcccgccggg gctcgacccg gccggcgccg
    37021 ccgcgctgcc gatggcggtg gagacggcct gccggggcct tgacgcactc ggcgtccgcg
    37081 acggcatgac cgtgctcgtg cacggcgccg ggaccaccgt cgggtatgcc gcggtgcaga
    37141 tggccctcca gcgcggggca cgcgtcgtcg ccaccgccgg cgagacctat gccggcgcgc
    37201 tgcgggccgc cggcgccgag gtcaccggtc atggcgacgg catggccgag cgcgtggcgg
    37261 ccctcgcggg cgggccggtc gacctcgccc tcgacacggc gccggtcagc ggcgcgctgc
    37321 cggcgctcgt gcgcaccgtc agggcgccgg aacacgtgct gacggtcagc gacttcgacg
    37381 cggcccggaa gctcggtgtc cggttcagcg gtcccggcgg tgagggcgtc atgagccacc
    37441 atgtgctcgg tgagtacgcg cggctcgcgg ccgaaggccg cttctcgatt ccggtcgctc
    37501 gcacgttcgc gctagaggac tggcgtatgg ccgcggaact gagccagtcg ggacgagcgc
    37561 gcggcaagct cgtcctggag atcgggtagt gcggtaggca tccggcgggt acgtccgggc
    37621 gtgtcacacg aggtccgtgc gaaacgtcgt ctccgtgacg gcagccgacg cagggagggt
    37681 gtcatggcgg acaggaagcg ggcggcgcag caggcgctgg tcgaccgcgt gctgggcggg
    37741 gacggcaggg cgtccgcgga cgagcgggcg cgcgccttcc gcgacgaggg cctcgaaccg
    37801 ccgctggacg cgctgatcgg caaggtcgcc ggcgacgcgg cgcaggtcac cgacgcggac
    37861 gtggcggcgg cgaaggcgtc cggccgcacc gaggacgagc tgttcgagct ggtggtgtgc
    37921 gccgcggtcg gccggtccgc gcggatgtac gacgccgggc tcgcggccct ggaggaggcg
    37981 ctcgccggag aggagcccgg gcatgcgtct tgacgtcctg aaccacggct accgtccggg
    38041 gacgaaactg ctgttcgcgg tcgtccggct gttctccggg catccgctgc cggacgcggc
    38101 gaagctgacg ttctaccgcc ccgacttcta cggtgcgcgg gccaaggagt tcacgcacga
    38161 ggcgatgcgc gggccgtcgg cctggtcggt cggcgaccgg gagctgatgg cggcctacgt
    38221 gtcgaaggtg aacgggtccg cgttctgcat cggcgcgcac accgcgaccg cgacgcgcgc
    38281 gtaccaggac gaggcgcggg tcacggcggt gttggacgag ctggacgcgc cgcccgtcga
    38341 ggagccgctg cggtcgacgc tgcggatgct cggcaggctg gtccgggacg ggcaggtcgc
    38401 cgccgccgac atgcgggagg tgctcgctgc cggcgcgacg cccgagcagg tgcgggacgc
    38461 cttggcggtc tgcgcggcct tcgacaccac cgaccggctc gccgacgcgt tcgggttcga
    38521 gctgctcagc cccgagggct acgcggcggg cgcgaagttc ctgctcaagc gcgggtaccg
    38581 gtagcggtca ggactcggcg gccaggcgga tgccgaggcc gacgaggacg atcccggaga
    38641 cctgctccat ccggcggcgg accgacgcgc gctggagcac cgtccgggcc cgtccggcca
    38701 gccagaccat cggcaggtac cagatcatgt cgatcgcggc ccagatcatg gagaacagga
    38761 cgagcgtcgc caggacgggc gcgccgtgcg ggacgaactg cggcaggaac gacaccgcga
    38821 acacccccgc cttcgggttg gcgaagttgg tgatggcgcc ctgccagaac gcgcgtccat
    38881 gcgagacggc cgacggctgg ggtgcctcct cctccgcctc ggtggcgtgc ctcgccttcc
    38941 acagcgcgcg cgcccccatg tacacgagga ccaccgcgcc cgtgatgcgc atcgcgtcat
    39001 aggcgaggcg cgaggcgagc aggagcgccg acaggccgaa cgcggcggcc aggccccaca
    39061 gcagcacccc gcactcgttg cccaggaccg tcgccatgcc gttgacgcgg ccgttcatca
    39121 ccgcccgccg aaggatcacg gcggtgctgg ggccggggac catcgcgatc aggaacgccg
    39181 cgccgacgaa tgccacgagc gaggacatca tccgtcgagt atccagagtc gcccatgtcc
    39241 cgacaacgcc tttcccacgc gaccggccgc cggcgccgag caggacgcgg atggtgtggc
    39301 gccggcggtg ccggcgctcg ccctggccac cgcttaacgc aactcgcact tgcgtttgcg
    39361 gtccggccgg acctacagtt ccgttaaacg cagtcgttga ctgctttagg aagcggcggc
    39421 gcatcccgcc gtgaacggga aggaaccgag atggacgacg tgatcgagcg gatcgaccgg
    39481 gccctcaccg cgacggccgc cgtcgtcggc gggatcggtg ccgcgcggct cgccgcgcca
    39541 tccccctgcc cgggctggga cgtgcgcgac gagctgaacc acctggtcgg cggcatgcgg
    39601 atcttcgccg ccgaactgac cggcaccgcc gccggcgccg accacgaggc cgactggctc
    39661 ggcggcgacc cgcacgccgc gttcggccgc gccgccggcc tcgaccgcgc ggcgtggcgg
    39721 cgtccggacg cgctccaggg caccgtgcgt ctcgggttcg gcgaggtccc cgcgccgatg
    39781 gccgcgctga tccacctcac cgaggtgctc gtccacggcg tggacctggc cgtcgccacc
    39841 ggtcaggacg ccctcgccga cgacgccgcc tgcgcgcacc tgctcacggt catgcagggc
    39901 atggacttcg gcgctttccg gcggcccggc atgttcggtc cggagcggac cgcccccgcc
    39961 ggcgcccctg cgcaccggcg gttgctcgcg ttcctcggcc gcgacctcgc ccgctgagac
    40021 gggcgtcggg ccgtccgatc ccggggcggc ggcgccgccc cggacgcggg gtcaggcgaa
    40081 ctggccgggg acgtagtcgc cggcgggctg ctgcgtgatg acgttcaggc ggttgtaggt
    40141 gttgatgatg gcgatcgtcc ccaccagcgc ggcgagctgc tcctcgtcga agtgcttcgc
    40201 ggcgttcgcc caggtcgcgt cgctcacccc ggccccgtcg gcgaggcggg tgccctcctc
    40261 ggcgagctcc agggcggcgc gctcggcctc ggtgtagacc gtcgcctccc gccacgcccc
    40321 gaccaggttg atccgctgct gggtctcccc ggcggccgcg gcgtccttgg tgtgcatgtc
    40381 gaggcagtag ccgcagccgt tgatctggct ggcgcggatc cgcaccagct cctgcgtcgc
    40441 gaccggaagc gtcgagtcgg cgacggcctt gcccgccgag ttgaggtact tcgcgacctt
    40501 catggcgagg tcgttcccat agaagtcgat acgggcgctc atggtgatcc ccttaaggcg
    40561 ttgggtccgt tgcctacacc cgtatgacgg gaccgcccgg cggaatgtga cgcgggatca
    40621 aggcagctgc gcgccgaacg cctggagcgc ctcggtgacc ggctggaaga acgtgacgcc
    40681 gcccgtccgg cagtcgcccg acccgcccga cgtcaggccg agcgcggtgg acccgctgaa
    40741 cagcggcccg ccgctgtcgc ccggctccgc gcacaccgtc gtctggatca tcccggtgac
    40801 cgtgccctcg gggaagttca ccgtcgcgcc gaccgccgtg acccggcccg tgtgcacgcc
    40861 cgtcgtgctg ccgctgcgcg cgacccgctg cccgaccacc gcgtccgcgg ccttcgtgat
    40921 cggctgcgcg gtgccgtcgt gcaggtcgac cgcgctctgc gcgccggccg tctcctggac
    40981 gagcgcgaag tcgttgcccg ggaagtcgct ctgcaccgtc gtgccgaggg cctgcgcgcc
    41041 ctcctgatcg gcggtccagt cctggacgat gttcccgcag tgcccggcgg tgaggaagaa
    41101 cggccgcccg gcccgctgca cgttgaagcc cagcgagcac cgcgcgccgc cgccgaagat
    41161 cgcgtcgccg ccgagcgcga gggtgcgcag ccgccccggg acgcgcacca tccgcacggc
    41221 cgcccccagg cccgccgccg cgcgccgcgc cgcggccatc cggggcccgg tgaccgagcc
    41281 gtcggtccac atcacgacct gcgacgtcgc cgggtcgacg gcccatccgg tgcccggcgt
    41341 cccggccatc gtgcggcgca gcgcggccgt cgcccggtgc agcgtccgcg ggctcgtgcg
    41401 catcgtcttc gggacggcgc ccgccgaccg caccatcgcc gcgtccgccg cgccggtgac
    41461 cgtgacgacg gggcgtcccg ccgcgtcgag gtacccgccc gcggtccggt cgccgagccg
    41521 cccggcgacc cgcgccgcga gcgccgcgga atcgcccgaa ccggcccttg ccgggcccgt
    41581 ccgcggccgg tcggctccgg ccagcttcgc ggcctgcggt ccctgcccgc cgtggacggc
    41641 gtacagcgat ccggcgatca gcgcggccgc gccggccacc gccgcgctcg ctgcggccac
    41701 ggtccgcgga cgacgttccc tcgcggcgtt ccggcgcctc atgagccctc cagctcccga
    41761 gttgacgatc tacgggaggt gttacggcgc ggcgcgttcc ggcgttcaac gcgccccgcg
    41821 ccgatgccgt gggacgccga cttcgctggt cagaggctta aggatctact tacggtcagt
    41881 agtcgcccgg atgcggtgcg ggtagatgag gtgacacggg cccagggcta gggcccatga
    41941 acccctggag ggaagatgaa gatcccgagt ccgctgcgct cggcggtgct gaccgccgcc
    42001 gggctggcga tggccgcagg gctggccgcc ttcgcccccg ccgcctcggc gagcgcggcg
    42061 gagacggccg cggccgtcca gtcgcacccc cggcactgcc cgtggggcac gcactgggac
    42121 atgcgctggc acagatgcgt tcgtgaccgc gacgaccacg gccacggcga ccacggcggc
    42181 tggcaccacg gccatggcga ctggcaccac ggccacggcc actggcacca cggccaccgc
    42241 tggtagagcg cactgaggcg accggccgtc ccgtccaccg agcgaggcgg ccggtcgctg
    42301 cgctcccgga cggcgccgcg ctcctggacg gcgccggggt cacgcgaggt cgcgggccaa
    42361 gcgggtcgcg ccgaccgcca tgtaggcgcc ggtcagcgcg gtgtagccca gggcggtggg
    42421 acgcgggagg tcgccgcggg cgaggcgggc ggcgccatga gcggtgtcga tgacgtcgac
    42481 cagcagcgcc agccgctgcc agcgggaccg gtcccgcccg gaggcggtca ggtaccccag
    42541 ccccagcgcg atcgcccgcg caccgaagat gcgggtcatg tagccgagct ccggcgtcgg
    42601 gcgcacgccg gacgccttcg ccatcgcgtt cggcgcgacg agcgccgcgg cgccgaggac
    42661 gatccgcccg gcggcgaggc cgcgcagcgc gaccgccaga gcgccctcac ccggctcgtc
    42721 ggcggacgtg ccggtgcgct cgccaccgga aacgatgctt tcttcacgag tgttcacggc
    42781 gcctatgctt caccgcatgg ccgtcccggc acttccacga acgtgcgctc gcgtgcggct
    42841 gtgggtgcgg ctcgggcacg tcgtctacgt cgggcccgcg ctcggcctcg gcccgcacgc
    42901 gacggcggtg gcctgcctgg gcgtcggcct cgacgcgccc ttcaccgtcc gcgccggcgg
    42961 gctgccggag cgcaccgtcc gcagcttcct gttccgcgcg cgggtccggc acgaggtcgt
    43021 cggcgggacg ggccggatgc tgttctgctt cttcgacccg acgtccgcgc ggatggcccg
    43081 gtgcctcggc ggcatgcggc gcaccgccgg cgggttcggc agcgaccacc accgcgaggc
    43141 cgacctgatc ggcctcgccg gccgcgacga cgtggacctc gaacggctgc tcgcggcggc
    43201 cagcatcccg gtggccacgg cccgcgaccc gcgcatcgcc cgcgtcgccg cccggatccg
    43261 cgacgacccg gcgcggccgc agcgcgcgga ggccgccgcc cgcgaggcgg ggctgtcccg
    43321 gtcgcacttc ctgcggacgt tctccggcca gaccggcacg agcttccgcc gctacgtcca
    43381 gtgggcgcgg atcctgcggg tcgccgaggc gtacgccgcc ggccacgact tcacccgcgc
    43441 cgccgccgac gccgggttcg cgtcgccgtc gcacctcagc ggcgccttcc gcggcatgtt
    43501 cgggctgacc ccgtcggcgc tcgccgcgct cggccccgag gtggtgctcg acgagccggg
    43561 ccgcgtcccc tgacctgcgg cggcgcgcgg gccggaggtg acctccgcgt ccgttatctg
    43621 cgatgatggc cggtcttgct cgtgaccgtg ccgtgatctt ccgcggcggc ggagcgggcg
    43681 gcgggcgccg gatcggccgc ggcacgggcc ggccggccag acgagggaag gacgcagcac
    43741 cgtggacgtc gaacggaccg ccctgccggg gatcggcctg cagcacgtca tgacgaccga
    43801 gcggggccgg cagctcggca tcatctcgca ccgctccggc cgccgcgacc tcgtcgtcta
    43861 cgaccgggag gaccccgaca gctgcgtcgc gacggtcgcc ctgaccgccg aggaggccaa
    43921 cgcgatcgcc gagctgctcg gcaccgggcg gatcgtcgag cacctcgcgg agctgcaccg
    43981 gcaggtcgag ggcctggtca ccgagcagct gccgatcgcg ccgggctcgc cctacgtcgg
    44041 ccggccgctc ggcgacaccc aggcccgcac ccggacgagc gcgtccatcg tcgcggtggt
    44101 ccgcgagggg caggtgttcg ccagcccccg gcccgacttc gtgttcgccg ccggggacgt
    44161 ggtggtggtc gtcgggacgg gcgagggcac ggcggccgtc gccgcgatcc tcgccgacgg
    44221 ctgaccccgc atggagtcgg ccgtccagct catcgaactc ggcgcgatca tcctggccct
    44281 cggggtgctc ggcgccgtgt ccgtccgctt ctccatctcc ccgatcccgc tctacctcat
    44341 cgccggcctc gcgttcgggt ccggcggcgt ctacccgctg acgaccagcg aggacttcgt
    44401 ctcgatcggc gccgaggtcg gcgtcatcct gctgctgttc acgctcggcc tggagtacac
    44461 cgccgacgag ctggtcggca cgctgaagac gtccgcgccc gtcgggctcg cggacatggc
    44521 gctgaacgcg ctgcccggcg tcgcggcggc gctgctgctc ggctgggggc cggtcgccgc
    44581 cgtcgcgatg ggcggcatca cctacgtcac ctcgtccggc atcaccgcga aggtgatcgg
    44641 cgacctcggc tggctcggca accgggagac gcccgcgctg ctgtcggtgc tggtgttcga
    44701 ggacctcgcg atggccgcct acctgccgat cctcacggcg ctgctggcgg gcgcggggct
    44761 ggtcggcggc gccgtcgcgc tcgcggtcgc cgccgcgacg atcgcggtga tcctgttcgt
    44821 cgcgctgcgg cacggcgcgt gggtggagcg gttcgtgtcc tcgccgagcg aggaggtgct
    44881 gctgctgaag gtgctcgggc tgacgctgct ggtcgcgggg atcgcgcagc agctgcaggt
    44941 gtccgcggcc gttggagcgt tcctggtcgg gatcgcgctg tcggggtcgc tggcgcacac
    45001 cgcgcacaaa ctgctgtcgc cgctgcgcga cctgttcgcc gccgtgttct tcgtcttctt
    45061 cggtctgcac accgacccgc acgacctgcc gccggtgctc ggcatcgccg cggtcctcgc
    45121 cgccgtcggc atcgccacca agctcgccac cggctggttc gccgcccggc gcgccggcgt
    45181 cgccgccacc gggcggctgc gcgccggcgt cgcgctcgtc ccgcggggcg agttcaacat
    45241 cgtcatcgcc gggctcgcgg tcagcgcggg caccaacgcc cgcctcggcc cgctcgccgc
    45301 cgcgtacgtc ctgatcctcg cggtggccgg gcccgtcctc gcgcgcggcg tcgaaccgct
    45361 gaccaggacc gtccgcgcgc gccggaccgc gcgccgcgaa cggacgccgc agaccgacga
    45421 cgacgtgccc gtcgcccccg cgccgcgccc cggcccggcg ggcggcggcc gctgaccgtc
    45481 agcccgtccc ggccgcgatc ccggcgaact ccgcgacgcg gcggttcggg ttcccggcgt
    45541 gccacaccag cacggcgcgg gacggcggca tgcccgtgaa cggcacgaac gccacgcccg
    45601 gatggctgaa atgccgcgcc atggcggtgc tcgcgacgaa cacgcccgcg ccctgcgcga
    45661 cgaggctgag catctccggc tcggtgcggg cctgcccggc gcgcgggatc ggctgcccgg
    45721 tgggtgtccg ctcgggcggc cagaacgatc gcagccactc cggcggcccg gacggcggcg
    45781 ccgcgatcac ccgcacgccg gcgaggtcct ccaggtcgac ggacggccgg gcggccagcg
    45841 ggtcggacgc ggcgaccgcc agcagccgcg ggtactcggc gacgaccggg ccggtgcgca
    45901 ggtcgtcctg ctcgaccggc cacgggcaca ccagcaggtc gatctcgccg ctgcgcagcg
    45961 gcgcgaacgg gtccgtccac gacgactgga cggtccggac ctggcaggcc ggatggcgct
    46021 cgcggaacgc ggcgatcgcc gcgtccagcg tgctgaagaa cgggccgagg aacccgatcc
    46081 gcagcccccg cgcgatgttg cgggcgtcgg tcagcgcgag gacgagcgcg tcgtaggcgg
    46141 gcgcggcgct ctccagcagg cgctcgccga gcggcgtcag ctccacccgg cggctggacc
    46201 gctcgaacag ccggccgccg atccgccgct ccagcgaccg gaccagctgg ctgacccgcg
    46261 gctgggagat ccgcagccgc tcggccgtcc ggccgaagtg cagctcgccc gccagcgcca
    46321 ggaacacctc gacctcggcc tgctccagcc gcacccggtc cggcccgccc tcatgcatta
    46381 actccactta tcaatcatgg cgaatgccgt ccttgatgcg gaagatcccc gtcccggatc
    46441 gtgtgacggg tggaaacgca acggcggctc gtcgtcggga tcagcggcgc gacgggcatc
    46501 gcctacgggg tgcgcgcgct ggagctcg
//
