LOCUS       NZ_CP053892            22781 bp    DNA     circular CON 05-MAY-2024
DEFINITION  Actinomadura verrucosospora strain NRRL:B18236 chromosome.
ACCESSION   NZ_CP053892
VERSION     NZ_CP053892.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura verrucosospora
  ORGANISM  Actinomadura verrucosospora
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M.
  TITLE     Actinomadura verrucosospora NRRL-B18236 (PFL_A860) Genome sequencing
            and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10214634)
  AUTHORS   Samborskyy,M., Dickens,S. and Scott,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2020) Biochemistry, DNA Sequencing Facility,
            University of Cambridge, 80 Tennis Court Road, Cambridge,
            Cambridgeshire CB2 1GA, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-DEC-2016
            Assembly Method                   :: Newbler v. 3.0
            Assembly Name                     :: A860_AS2.mpe1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_013211575.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 03:37:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,277
            CDSs (total)                      :: 9,181
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 96
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 18 of 71
            Pseudo Genes (incomplete)         :: 57 of 71
            Pseudo Genes (internal stop)      :: 2 of 71
            Pseudo Genes (multiple problems)  :: 6 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:15:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5274118
            Orig. end                         :: 5296899
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP053892.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Peter Leadlay,
            NRRL-B18236 (patent collection, not in online catalogue).
FEATURES             Location/Qualifiers
     region          1..22781
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="17"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22781
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22781
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12781](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12781
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    1267..1280
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            complement(1407..4223)
                     /locus_tag="ACTIVE_RS22905"
                     /old_locus_tag="ACTIVE_4577"
     CDS             complement(1407..4223)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012906.4"
                     /locus_tag="ACTIVE_RS22905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4577"
                     /product="sugar-binding domain-containing protein"
                     /protein_id="WP_173096969.1"
                     /transl_table=11
                     /translation="MSGSRTRTTALCAALALAGTILPTMPAHAFSAPRASVQKVQPSGT
                     TELTSGWAIRSSADTGDTGAEISKPGYSTQGWLPLSRPETLMAGLLENGKYPNIFHNDN
                     MAKVPAKQFDVNWWYREQLTLHPRKDGRTFLVMNGVSGKADLWVNGTKVAAGAQFQGSY
                     ARLEYDITPYVRDGANAIALDVSRNDSDITKFDTPMRYLTQNQVDWNPMAPDQNTGLQY
                     APQIVQEGPVSVRNAHVLQDDAADLSTADLTVKADVRNNTASAQRVTVSGTITHGSTRI
                     ACTATVTVPARATRTVTITKADCPGLHLRHPAVWWPYQMGDQPMYHLALNASVGGTVSG
                     SAAEDFGIRTVTSRLTKPVAGKTHGKNGYRQFIVNGKPLVIRGAGWSPDLFLRYSRSDI
                     ADQISYIRNMGLNAVRFEGNFPPDDMFAQLDRAGVLAMPGWQCCALWEGESSTWSDEVK
                     ANASNQARTMAERLRDHPSVFTFFQGSDNAPDAEKEALFLKAFKEADFRLPQVAAAEYK
                     SSPKLGPAGTKEGGYNYFPPNALWNNKRETVNTKDPSLSMTGSAWGFDTEVSTGNTIPT
                     QDSLNRFLPADEQKKIWDPATAKGQTAGQDMYHTFFYSDYTRLSRMGVYNTPLWHRYGP
                     WKDAGSYQKTVQLGEYEVTRAQFESYIGNSTDKANPSTGIIYWMLNKAWPSLQWSMYGS
                     DFDQPGVYFGAKKANEPVHIMYSYADGSIKAANLTGARQAGLRATAQIIDLDGKVRATA
                     SAPVGALGSQDVRTVLHPKVPAGISKTYFEKLTLTRGSEVVSRNVYWLSTKADQVDWPK
                     THAPGKYTPSNGFAVFQKDGYADLTGLRSLKPADIKVDATTRREGGDMVTTVTVRNTGH
                     GGTPALFTRADLFAGGEQVLPIRWSDNDITLWPGEQQTITARYSATSAKPDVRVNGFNV
                     PTQTHPTR"
     gene            complement(4344..5810)
                     /locus_tag="ACTIVE_RS22910"
                     /old_locus_tag="ACTIVE_4578"
     CDS             complement(4344..5810)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="ACTIVE_RS22910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4578"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_173096970.1"
                     /transl_table=11
                     /translation="MVTAGLTVTGLTADVPGRRVVHGVDLAVPAGRVLALVGPSGSGKT
                     LTARAVAGLHPHGGTVLVDGRPPVRGRDVGYAFQDALASLNPTVTVRRHLTETVKAHGT
                     GDPAAALARFGLDPALAAAHPFELSGGQAQRVALALATVHEPPVLIADEVTTALDPVTQ
                     ATVLDLVRAQARDRAVLLITHDLTAAARWADDIAVMRDGRIVEHGPAERILGEPESDLA
                     RELVAAATAEVPADGPAAAVAEGEAVAVRGLRRVLRSRRRTTVALDGADLAVRPGEAVA
                     IVGRSGSGKSTLVGALAALDRPDGGSVLRAGADVWALRDRERRAVRRRTGLVFQDPLAS
                     FDPRHTVRQAIAEAGPYDDDLLRYVGLDPAMAARRPGTLSGGECQRVAIARALAQKPDV
                     LLADEPTSGLDVLTEERVLRLLTALRRDHGITIALVTHDLRVARRVADRVVVLHAGRIV
                     EDLPAHALDSASHPETRRLLDATALTGKWA"
     gene            complement(5804..6712)
                     /locus_tag="ACTIVE_RS22915"
                     /old_locus_tag="ACTIVE_4579"
     CDS             complement(5804..6712)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017626114.1"
                     /locus_tag="ACTIVE_RS22915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4579"
                     /product="ABC transporter permease"
                     /protein_id="WP_173096971.1"
                     /transl_table=11
                     /translation="MPPDAPAPATATASATASAPARVRGLLAVRLRPRRPALIAAVAVL
                     AALALLAILAPLFTSLDPVATDTSATSLKPGSPGHPLGTDLLGRDLWTRMLYGARTSLL
                     VGLTAAAITVGLGLLIGGLAAIAPRWLDGLIARTADVLLALPLLVIVLALAAVAGPSRG
                     LVVAAIALTSWMPVALIVRAELRSRRERLYVRAAYALGLSRRQVMWRHLLPGALPPVAS
                     IAAFEVGHAVLTESTLSFLGLGVPPNRPSWGNLLTEAQSHLLTGEWYTVAIPAAAVVAT
                     IIAVNVVAGAVAGPADEGRTW"
     gene            complement(6702..7685)
                     /locus_tag="ACTIVE_RS22920"
                     /old_locus_tag="ACTIVE_4580"
     CDS             complement(6702..7685)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658538.1"
                     /locus_tag="ACTIVE_RS22920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4580"
                     /product="ABC transporter permease"
                     /protein_id="WP_173096972.1"
                     /transl_table=11
                     /translation="MALRAVRRLATAALVVAALSAVCFGLLDAAPGDPAASVLESRSGG
                     RPPSPAAVAELRGEMGLDDPPPVRYWRWASHAVRGDLGTSYMSGRPVTETLGDTVPWTL
                     LLTAAAILLSFTAALAVGLVAALTRRAWLRRGIDLLLFVTGGMPGFVVALLLLYAFAAA
                     THLMPSGGVSRPGEPVTAYGLLAHLALPACALAFGHHFGVYVRLVENGVGRLRDAPHVQ
                     NARVRGLPRRTVVARHLMRPGLVPFTARLGVGVGTLIAGVYATEVIFSWPGMGREAITA
                     ARAQDYPLLIAIVLVTGLIVIAANLAAELIVAALDPRARTGRADAA"
     gene            complement(7686..9251)
                     /locus_tag="ACTIVE_RS22925"
                     /old_locus_tag="ACTIVE_4581"
     CDS             complement(7686..9251)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658539.1"
                     /locus_tag="ACTIVE_RS22925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4581"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_246342031.1"
                     /transl_table=11
                     /translation="MVKRPVLAVMAVVMAASVASACGQGDGPASGTKDGSLTYAIGDEP
                     ETFNPGLQDEHTDPVTELVFRGLTRHDKDNKVVPGLARSWTIAPDGRTYTFALRPGATW
                     QDGRPFTADDVKFTIEAVRDAGADSPLSRNFTMVKSVETPDPATVRLVLDEPFAPMLDA
                     VSMGMLPKHLLQGKKLTDPGFGQHPVGTGPFTLTTYKHGQYAELTAFDGYYEGKPGLKK
                     VVIKYVPDDSARLIQLRNGEVDAANLAPQQAGKAGGHRLEVYPTADYRALMFNMKDPVF
                     ADRRVRQAMNHAVDRDAIAKSVVLGYGSPAKGPLDAGPYAAAPGFTFDPAKTASLMKDA
                     GYAKNGQGLWAKNGRTVKFELTTFAEDSLRVAILNVSATQLKQQGFEVDPRPRPRDWVR
                     KHWGDLQGMVVGWGTPYDPDSSVYGPFATSQALAKGGSNYGSYSNPAADKALEEGRSTL
                     DPAKRKAAYTAFQQALQDDPPFVWISYLKTINAVPKNLTGPAQRTLGHHGYGFFWNAET
                     WRYN"
     misc_feature    complement(9233..9246)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.44"
                     /tool="antismash"
     misc_feature    9260..9278
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 21.35"
                     /tool="antismash"
     misc_feature    complement(9264..9282)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.93"
                     /tool="antismash"
     misc_feature    9267..9285
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    9279..9297
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 19.93"
                     /tool="antismash"
     misc_feature    9520..9534
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     misc_feature    complement(9665..9682)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.53"
                     /tool="antismash"
     misc_feature    complement(9681..9694)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.73"
                     /tool="antismash"
     misc_feature    complement(9683..9696)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.47"
                     /tool="antismash"
     misc_feature    9685..9698
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.14"
                     /tool="antismash"
     misc_feature    complement(9831..9844)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.04"
                     /tool="antismash"
     misc_feature    9831..9844
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.65"
                     /tool="antismash"
     misc_feature    9831..9845
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 13.83"
                     /tool="antismash"
     misc_feature    complement(9832..9845)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.74"
                     /tool="antismash"
     misc_feature    complement(9836..9849)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.86"
                     /tool="antismash"
     gene            10001..12781
                     /gene="lanL"
                     /locus_tag="ACTIVE_RS22930"
                     /old_locus_tag="ACTIVE_4582"
     CDS             10001..12781
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="ACTIVE_RS22930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4582"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_216857905.1"
                     /sec_met_domain="Pkinase (E-value: 1.9e-19, bitscore: 69.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.8e-06, bitscore: 27.1,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1e-45, bitscore:
                     155.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDFNFSVFSAAPAAADEDTALTDLLATAVGRAPAARRWRTGRAG
                     LWCTAVPDGAPRRGQGWKLHVTGTPAAAPEILERCLEVLLGAGSAFKFAATTDYVAAMN
                     ARNTPRGHSGKFITVYPESDDEAVRLAAALHAATAGLPGPRILSDRPYAPDSLVHYRYG
                     AFTEDRRLTNDGFYAWMIIDPDGNPVEDRRLGRYTPPPWATCPFPDNGRRVTRAEGRSG
                     KDIVIGGRFAVKNAIRHTNKGGVYRAVDVRTGDAVVLKEARPHVAADPEGRDTRDRLRA
                     EARALERIRHRGIAPRPAGLFTESGHLFLAQEMIPGTPLREWTSDSIRDAGWGPHLAPA
                     LEMARRLADLMIEAHATGLVLRDFNPNNVMVRPDGAPVLIDLELAVVAGDGEETPLRAG
                     TPAFSSPEQFEGAPPHATADYYSLGATLCYVLTGGPPYFMEERPRSRPLTQRLTEWLAA
                     RTQGLDLPESLRAVLVELMADDPGRRCTPARARSVLASISSSPVPAQSRADEDAGPDEW
                     LQEACEQAVRGITGRLLAAMEPESAQALWPMSCVHGAPDPCCVQHGAAGGLGALVRYMR
                     HTSDPRLPDASATAARWMLDRLRDGARRPSGLYFGTAGVAWALLDAGLALGDDGLAEEA
                     AAIAEALPVTAPGPDVTHGTAGIGMTALHLWARTGRKPFAERAQAAADALAASVEEGPD
                     GLVWRTPAHVESKLAGKSYYGFAHGIAGVGYFLLACAEATGRAEHRELAVRVGESLLDA
                     AVVTPRSAMWGAGTGDPPTAPYWCHGASGIGTFLVRLGAATGDARFARAADLSARAVTD
                     QSWRAVLGQCHGLAGNGDFLLDMADVTGDARHRAAAWRLARIIIASRAHRDGRIVLPDE
                     RGDVSMSWGEGLSGVLAFLVRLRYGGERLWMADAASAPGAAEDAVAGTAVRGSAP"
     misc_feature    10004..10020
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.24"
                     /tool="antismash"
     misc_feature    10005..10019
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.4"
                     /tool="antismash"
     gene            12778..14715
                     /locus_tag="ACTIVE_RS22935"
                     /old_locus_tag="ACTIVE_4583"
     CDS             12778..14715
                     /NRPS_PKS="Domain: Abhydrolase_1 (411-526). E-value:
                     3.1e-12. Score: 38.6. Matches aSDomain:
                     nrpspksdomains_ACTIVE_RS22935_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.4"
                     /locus_tag="ACTIVE_RS22935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4583"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_173096973.1"
                     /sec_met_domain="PF00561 (E-value: 2.9e-09, bitscore: 36.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 3.6e-19, bitscore:
                     68.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATVNGTVNGTAGDAAEAAVPALPGIPSRFGLAFSAGGRWAACL
                     SAVDDHVTLERWNLARAVPSRRVFGGGTVASGPGRREPVDRHSRPLPLDDGRLLVVRAE
                     VDAHGTPAGHGTVVAAQAGHGGTTVGRSWAVPSMLAGYALASPGAPQTVVLVTVQDEHR
                     SRIWELSLATGTLEPVMEIPGALSGGVWLDDGRTLALDQATADHRADGIAVDLRERSWR
                     RVWSVAAATADRIVACDRRSGTLAVTTGLPGAQWTGALRIGLWTPGGGRVRFPAALNRP
                     AGGMVPLAFDDTGAHLLVSEVSGAVSRLLVHTRADDRLEPVAVPPGLAGAPASWTGDRI
                     HLRFSAPHLPPTLATAHTAAAHPPLAGWAPVRRAPDVAADWRAADLVELPGPAGPIEAI
                     VYGGPRWRERRHLVLALHGGPLSAWRFEFDPLFQHLAAAGVAVVAPNQRGSTGYGEPHL
                     RAVIGDWGGPDLDDVVHLARGIVRPRRDAGLPEPVVLGGSYGAFLALLAACHSPDLWSG
                     CVALAPFTSADGLYRDAPGPVRDRVARLDRVGGGTDGARDVLRRCDALTAPLLLAHGTR
                     DEVIPVAHSRALRRRLLELGRTEGTGLGYIEVDDGHTAVVQAWSRVLRTAVVRFCLTAE
                     RISATTTEGR"
     aSDomain        14011..14355
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACTIVE_RS22935_Abhydrolase_1.1"
                     /evalue="3.10E-12"
                     /label="ACTIVE_RS22935_Abhydrolase_1.1"
                     /locus_tag="ACTIVE_RS22935"
                     /protein_end="526"
                     /protein_start="411"
                     /score="38.6"
                     /tool="antismash"
                     /translation="LVLALHGGPLSAWRFEFDPLFQHLAAAGVAVVAPNQRGSTGYGEP
                     HLRAVIGDWGGPDLDDVVHLARGIVRPRRDAGLPEPVVLGGSYGAFLALLAACHSPDLW
                     SGCVALAPFTS"
     misc_feature    14720..14735
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.06"
                     /tool="antismash"
     gene            14721..14879
                     /locus_tag="ACTIVE_RS22940"
                     /old_locus_tag="ACTIVE_4584"
     CDS             14721..14879
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038147.1"
                     /locus_tag="ACTIVE_RS22940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4584"
                     /product="VenA family class IV lanthipeptide"
                     /protein_id="WP_173096974.1"
                     /transl_table=11
                     /translation="MENIFEGDLVAELQELPETDPIEIEGVQLSGTCACAGLLTLLNSV
                     CVGISCA"
     gene            15042..16826
                     /locus_tag="ACTIVE_RS22945"
                     /old_locus_tag="ACTIVE_4585"
     CDS             15042..16826
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="ACTIVE_RS22945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4585"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_173096975.1"
                     /transl_table=11
                     /translation="MPEPESEAGAPAALRREGRRLLRAAARRFRALLALLAAATVVRVA
                     AMLATPVMLGRAIDAVRSGHGLGAAIAGLAFVLLTAALADAAEELLGTYCGSRITAWLR
                     HRLVGRVLELGVPGRRRFPAGDVLSRLTESAGGPAAFPALLLSGAAALATTAGAVVALA
                     LIDWTLALVFALGVPPAVLALRMFVAKAGAPFADYQRHQAEIGTRLLDARQGARTIRAS
                     GTTAREVRRILRPLPLLGAAGRLTWDAQGQVGWRLSLLAPLLQITVVGAAGFRLAAGDV
                     TAGELVAAASYTAMAVGAAALFDTFVALLNCEVGAGRVAEVLDAVPAVRPPERPVPLPD
                     GPGALRLRGVTVRVGGRTVLDRLDLAVPPNTAVAVVGTSGSGKSVLVAAIARLVDPDEG
                     RVELDGVDVADVALPELRRAVAYAFERPALLGATVHDMIAYARPGAARAEVRRAARTAA
                     ADGFVRALPAGYDTPLAEAPMSGGELQRLGLARAALADARLLVLDDATSSLDTATEMRV
                     TRALREVLAGRTSLVVARRPATAARADLVAWLDAGRIRALAPHAELWADPRYRAVFAAE
                     PGEPGDPVPAAAAPGPAA"
     gene            16823..18610
                     /locus_tag="ACTIVE_RS22950"
                     /old_locus_tag="ACTIVE_4586"
     CDS             16823..18610
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="ACTIVE_RS22950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4586"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_216857906.1"
                     /transl_table=11
                     /translation="MTAAPAASAAERAAVPAAKGRTAAPAARLLRRHLRGRGPALRRLA
                     LWSAVESLPAFASGLLLAHAIDDGFLARRPFTGLAWLAALGALQAAGALGTRRIYPWLA
                     ATVEPLRDSLVGEVVAGALRRTVDRAADPSSGGAGAGISQVTEQAEAVRMLLGTALRNV
                     RQMLAAGLAALLGLTLLAPLPALTAAVSVALALGLFAALLGVQVRRYRAVVREAERIGE
                     TATEIVQGVRDVVACAAEPRAARTVGEAIDAQAGALRSFARSRLVRLPVLALGVHLPLL
                     ALLALSPRLVDDHRLTTGQVAGGVSYLVTGLQPAMVLLVDAGGTLLLSLAVVLGRLAEV
                     CAGPDAAPRPAAPVAATSYGLEAEHVTFAYSASAAPVLADLSLHIPEGTHLAVVGPSGT
                     GKSTLADVLTGLARPQRGSVTLGKVALADLGEERLRAAVALVPQESYVFAGTLRENLAY
                     LRPDASDADLDAAVDAIGLRATVDRLGGYDAAVPPGGGTLSQGERQLVTLVRAHVSGAP
                     VTILDEATCHLHPAAEARAERALAARGGTLIVIAHRISSAQRAQRVLLLDGSAPLLGTH
                     DALLALSPLYAELVGHWRT"
     gene            18725..20875
                     /locus_tag="ACTIVE_RS22955"
                     /old_locus_tag="ACTIVE_4587"
     CDS             18725..20875
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015155.4"
                     /locus_tag="ACTIVE_RS22955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4587"
                     /product="MMPL family transporter"
                     /protein_id="WP_173096976.1"
                     /transl_table=11
                     /translation="MPTAAPERRPAGLARLGAFCARHPWWVLAAWIVLLVAALGGRKAV
                     GPTFSDQVSLPGTQSDTGKILLTASDPAANRPNGQVVFHVAAGTVSAHQQAVDQSLGNL
                     KALPHVTGVPTPLTSTDGRTVSATVSFDEQLAQLGHGYTARLDDATEPARAAGVGVGYG
                     GDFTQIVRPPANDLLSELVGIGAALVVLLAAFGSVGAAVTPLITALVAVAVGTGVVGIV
                     AGVITFATAAPTLATMLGLGVGIDYALFLTTRFRQDLIEGRSPVDAAGRAAGTSGHAIA
                     VAAITVVVALLSLYASGLSFIGRLGLAATIAVLISAAAALTLVPAALGLAGRSIDRLAV
                     RRPVAETSSARDSWHRYAGLIERHRWTSLAAGLVLPVVCAVPVFSMRLGHVDAGADPSG
                     STTRNAYDWVAGATGPGFGPGANGPFTVVTDVRHATVPAGQISSDLSHALQSTHGVASA
                     TQPQPSPDGALLVSTVTPTTGPQTASTSDLFRTLTDDTLPGALHGTGAKAYLTGTTAGR
                     LDFRDTVARRLPIIIGIVLVLAYLLLMSVFRSLVIPLKAVLLNLLTTAASWGALVAVFQ
                     WGWGDAVLGLPEGVPIESYVPMMMFAIVFGLSMDYEIFLLSRMAAVWDGTHDNTRAVAG
                     GLAVTGRVVSSAALIMTVVFLSFTASPTVVVKMLALGLAFSVILDATIVRLVLVPSLMF
                     LMGSSNWWLPRRLARTLPHLHA"
     gene            complement(20843..21619)
                     /locus_tag="ACTIVE_RS22960"
                     /old_locus_tag="ACTIVE_4588"
     CDS             complement(20843..21619)
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012517.4"
                     /locus_tag="ACTIVE_RS22960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ACTIVE_4588"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_246342033.1"
                     /transl_table=11
                     /translation="MDGLLIPAPFDVTRLAASAAFGLHGALLQQPGAESPDFADAVDDI
                     AALIAGTYAKDGHEAHANPGEGAALDLWILGSSGGQSARVAGARGLPFAANYHVSPSNV
                     LEAVEAYRAAFRPSDVLDEPYVIVSADVVVAPTDAEARDLASPYALWVHSIRSRLAAIP
                     FPTPAEAAAHDWRPEDLDLVADRVDTQFTGAPGTVADGLATLQRVTGADELLITTITHD
                     HADRVRSYDLLAEAWATTTPKPPPAPLGVEVGERAG"
     gene            complement(<21748..22011)
                     /locus_tag="ACTIVE_RS47540"
                     /pseudo=""
     CDS             complement(<21748..22011)
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012517.4"
                     /locus_tag="ACTIVE_RS47540"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="LLM class flavin-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTPLSVLDLAPISAGGTARDALRNTLDLARRTEAAGYRRYWLAEH
                     HLAPGVASAAPQILIEAVAAATSRIRVGSGAVQTGHWTPLSIV"
ORIGIN
        1 gcgcagatcg gccggctgct ggacttcctg gacgatctcg gacggctcga cgacacgctc
       61 atcgtcgtca tgtccgacaa cggggcgagc gcggagggcg gtcggctcgg cactccgaac
      121 gagcaccgct tctcggcgcg catgggcgac acccacgagc agaacctggc ggcgctggac
      181 gactggggct cccccgagac gtacccgcac tacgcgtggg gctgggcgtg ggcgggcaac
      241 acgccgctgc ggctgtggaa gcgctacacc tggctcggcg gcacccgcgt cccgctgatc
      301 atgcactggc cgcgccgcat caccgcgcgc ggcgaggtcc gcgagcaggt cgtgcacgcc
      361 gtcgacctga tgccgacgat cctggaggcg gccggcgtgc ccgcgccgcg ggtcgtggac
      421 ggggtcgagc agcagcccgt cgacggccgc agcctgttcc ccaccttcga cgacccggac
      481 gcgccgccgc cccgcgagac gcagtacttc gagatgctcg gctcccggtc gatcatccac
      541 ggccgctgga aggcgaccac cgaccacgtc tcgcgcggcg tcctggacga ggaggccctg
      601 atccgcggca gccgcgactt cgcgacggac cgctggtcgc tgttcgacct gtccgccgac
      661 ttcgccgagg ccgtcgacct cgccggcgag caccccggcg tcgtcgccga cctggaggcg
      721 cgctgggccg ccgaggcgga gcgcaaccac gtgctgcccc tgcaggactc gctgcaggac
      781 cggctcgcgc acctggtcct cccgccgtac gggttcccgc gccgggccgt ctaccggccg
      841 ggcggcggtc ccgtccacga cgagtcgctg ccgctgctga ccggcgggtt cacgctgacg
      901 gccgacgtcg acatcgcgga cggcggcgcg gacggcgtcg tctgcgcgct cggcgaccgc
      961 atcggcgggt tcgtgctgca cgcggtcggc gggcgcctcg ccttcgcgtg ctcccgcgcc
     1021 ggcgacctcg accgcgtcac cgccgcggag ccgctgccgt ccggccgcca ccgcatcggc
     1081 gtcggcgtcc gcggcggcac gatcacgctg tacctggacg gccgggacat cgcgtccggg
     1141 ccgctcggcg gcgagtggcc cgtcacgttc cagcacggcg gcgccggcct gcgcatcggc
     1201 cacgacgccg ggctgcccgt cgaggacggc taccgtcccc cggcccgctg gaacggcacc
     1261 gtccacctga tcgagatcga caccgcgccc gtccccgatc ccaccgcgca ggacggcctg
     1321 cgcaccgccc tgcacagcga ctgacccctg cgaagtgcgc gaaggccgga cggaggtgag
     1381 tccgtccggc cttcgcgtga gaagggtcag cgggtggggt gggtctgggt ggggacgttg
     1441 aagccgttga cgcggacgtc gggcttggcg gacgtggcgg agtagcgggc ggtgatggtc
     1501 tgctgctcgc ccggccagag cgtgatgtcg ttgtcgctcc agcggatcgg cagcacctgc
     1561 tcgccgccgg cgaacaggtc ggcgcgggtg aacagggccg gcgtgccgcc gtggccggtg
     1621 ttgcggacgg tcacggtggt caccatgtcg ccgccctcgc ggcgggtggt ggcgtcgacc
     1681 ttgatgtcgg cgggcttgag ggagcgcagg ccggtgaggt cggcgtagcc gtccttctgg
     1741 aagaccgcga acccgttgga cggggtgtac ttgccgggcg cgtgggtctt cggccagtcg
     1801 acctggtcgg ccttggtgga cagccagtag acgttgcggc tgacgacctc ggagccgcgg
     1861 gtgagggtga gcttctcgaa gtaggtcttg gagatcccgg cggggacctt cgggtgcagg
     1921 acggtccgga cgtcctggct gcccagcgcg ccgaccgggg cgctcgcggt ggcgcggacc
     1981 ttgccgtcga ggtcgatgat ctgggcggtg gcgcgcaggc cggcctggcg ggcgccggtg
     2041 aggttcgcgg ccttgatgga gccgtcggcg taggagtaca tgatgtgcac cggctcgttg
     2101 gccttcttgg cgccgaagta gacgccgggc tggtcgaagt cggagccgta catgctccac
     2161 tggagcgacg gccacgcctt gttcagcatc cagtagatga tcccggtgct ggggttggcc
     2221 ttgtcggtgg agttgccgat gtacgactcg aactgcgcgc gggtgacctc gtattcaccg
     2281 agctggacgg tcttctgata cgagccggcg tccttccacg ggccgtaccg gtgccacagc
     2341 ggggtgttgt agacgcccat ccgggaaagg cgcgtgtagt cggagtagaa gaacgtgtgg
     2401 tacatgtcct ggccggcggt ctggcccttc gcggtggccg ggtcccagat cttcttctgc
     2461 tcgtccgcgg gcaggaagcg gttcagcgag tcctgcgtcg ggatggtgtt gccggtgctg
     2521 acctcggtgt cgaatcccca ggcgctgccg gtcatgctga gcgacgggtc cttggtgttg
     2581 acggtctcgc gcttgttgtt ccacagggcg ttcggcggga agtagttgta gccgccctcc
     2641 ttggtgcccg ccgggccgag tttcggcgac gacttgtatt cggcggcggc gacctgcggc
     2701 agccggaagt cggcctcctt gaaggccttc aggaaaaggg cctccttctc ggcgtcggga
     2761 gcgttgtcgc tgccctggaa gaaggtgaag acgctcgggt ggtcgcgcag ccgctccgcc
     2821 atggtccggg cctggttgga cgcgttggcc ttcacctcgt ccgaccaggt ggacgactcg
     2881 ccctcccaga gggcgcagca ctgccagccc ggcatggcga ggacgccggc ccggtcaagc
     2941 tgggcgaaca tgtcgtccgg cgggaagttg ccctcgaacc ggacggcgtt gaggcccatg
     3001 ttgcggatgt aggagatctg gtcggcgatg tcgctccgcg agtagcgcag gaacaggtcg
     3061 ggcgaccatc cggcgccgcg gatgacgagc ggcttcccgt tgacgatgaa ctgccggtag
     3121 ccgttcttgc cgtgcgtctt gccggcgacg ggcttggtga gccgcgaggt gacggtgcgg
     3181 atgccgaagt cctcggcggc ggagccggag acggtcccgc cgacggacgc gttgagcgcg
     3241 aggtggtaca tcggctggtc gcccatctgg tagggccacc acacggccgg gtgcctgagg
     3301 tgcaggccag ggcagtccgc cttggtgatc gtgacggtgc gggtcgcgcg ggcgggcacc
     3361 gtgaccgtgg ccgtgcaggc gatgcgggtg gagccgtgcg tgatcgtgcc ggacaccgtc
     3421 acccgctgcg ccgacgcggt gttgttgcgc acgtcggcct tgacggtgag gtcggcggtg
     3481 gacaggtcgg cggcgtcgtc ctgcaggacg tgcgcgttgc ggaccgagac cgggccctcc
     3541 tggacgatct gcggcgcgta ctgcagcccg gtgttctggt cgggcgccat cgggttccag
     3601 tcgacctggt tctgggtcag gtaccgcatg ggcgtgtcga acttggtgat gtcggagtcg
     3661 ttgcgggaga cgtcgagcgc gatcgcgttc gcgccgtccc ggacgtacgg cgtgatgtcg
     3721 tattcgaggc gcgcgtacga gccctggaac tgcgcccccg cggcgacctt ggtgccgttg
     3781 acccagaggt cggcctttcc ggagacgccg ttcatcacca ggaacgtccg cccgtccttg
     3841 cgggggtgca gggtgagctg ctcgcggtac caccagttca cgtcgaactg cttggccggc
     3901 accttcgcca tgttgtcgtt gtggaagatg ttcgggtact tgccgttctc cagcaggccc
     3961 gccatcagcg tctcgggccg ggacagcggc agccagccct gcgtggaata gcccggcttg
     4021 gagatctcgg cgccggtgtc gccggtgtcg gcggacgacc ggatcgccca gccggaggtc
     4081 agttccgtgg tgccggacgg ctggaccttc tgtaccgagg cccggggcgc ggaaaaggcg
     4141 tgcgccggca ttgtgggaag gatcgtcccg gcaagggcga gtgcggcgca cagcgccgtc
     4201 gtccgcgtcc tggacccgct catctgtcca tcactccctg gtgcggccgg agccgggagc
     4261 ttttccccgg cggctgatgt cgtcaatgct ccggccggag ccgccccgcg ggccgtaggg
     4321 gcaggacgcc aatgggggta gtgctaggcc cactttccgg tgagggcggt ggcgtccagg
     4381 agccgcctcg tctcggggtg gctcgccgag tcgagcgcgt gcgcgggcag gtcctcgacg
     4441 atccgtccgg cgtgcaggac gacgacgcgg tcggcgacgc ggcgggcgac gcgcaggtcg
     4501 tgggtgacca gcgcgatcgt gatgccgtgg tcgcggcgca gcgcggtcag cagccgcagg
     4561 acgcgctcct cggtgagcac gtcgaggccg ctggtgggct cgtcggcgag cagcacgtcc
     4621 ggcttctggg cgagcgcgcg ggcgatcgcg acgcgctggc actcgccgcc ggacagggtg
     4681 ccggggcggc gcgccgccat ggcggggtcg aggccgacgt agcggagcag gtcgtcgtcg
     4741 tagggaccgg cctccgcgat ggcctgccgg acggtgtgcc gggggtcgaa ggaggcgagc
     4801 gggtcctgga acaccaggcc ggtgcggcgc cggacggcgc gccgctcgcg gtcgcgcagc
     4861 gcccagacgt ccgcgccggc gcgcagcacc gagccgccgt cggggcggtc gagggcggcg
     4921 agggcgccga cgagcgtgga cttgcccgac ccgctgcgtc cgacgatcgc gacggcctcg
     4981 ccggggcgga cggccaggtc ggcgccgtcc agcgcgacgg tcgtgcggcg ccgggaccgc
     5041 aggacgcgcc gcagtccccg gacggcgacg gcctcgccct ccgccaccgc cgcggccggt
     5101 ccgtccgcag ggacctcggc ggtggcggcg gcgaccagtt cccgcgccag gtcgctctcc
     5161 ggctcgccga ggatccgctc ggcgggcccg tgctcgacga tgcgcccgtc gcgcatgacc
     5221 gcgatgtcgt cggcccaccg tgcggcggcg gtcaggtcgt gggtgatgag caggacggcc
     5281 cggtcgcggg cctgcgcgcg gacgaggtcg agcacggtcg cctgggtgac cgggtccagc
     5341 gcggtggtga cctcgtcggc gatgaggacg ggcggttcgt gcacggtggc gagcgcgagc
     5401 gcgacccgct gcgcctgccc gccggacagc tcgaaggggt gcgcggcggc cagcgccggg
     5461 tcgaggccga accgggccag cgcggcggcc gggtcgccgg tgccgtgcgc cttcacggtc
     5521 tcggtgaggt gccgccggac ggtgacggtc gggttgagcg aggcgagcgc gtcctggaac
     5581 gcgtacccga cgtcccgccc gcgcaccggg ggccggccgt ccaccaggac ggtcccgccg
     5641 tgcgggtgca ggcccgcgac ggcgcgggcg gtgagggtct tgccgctgcc gctcggcccg
     5701 acgagcgcga ggacgcgccc ggcggggacg gcgaggtcga cgccgtgcac gacgcggcgt
     5761 ccggggacgt ccgcggtcag cccggtgacg gtgagtccgg cggtcaccat gtcctgcctt
     5821 cgtccgcggg gccggcgacc gcgccggcga cgacgttgac cgcgatgatc gtggcgacca
     5881 cggcggccgc ggggatcgcg acggtgtacc actcgccggt gagcaggtgc gactgcgcct
     5941 cggtgagcag gttgccccag ctcggccggt tcggcgggac gccgaggccg aggaagctga
     6001 gcgtcgactc ggtcagcacg gcgtgcccga cctcgaacgc ggcgatggac gcgacgggcg
     6061 gcagcgcgcc gggcagcagg tgccgccaca tcacctgccg gcgggacagg ccgagcgcgt
     6121 aggcggcgcg gacgtagagg cgctcgcggc ggctgcgcag ctcggcgcgg acgatcagcg
     6181 cgaccggcat ccagctcgtc agcgcgatcg cggcgacgac gaggccgcgg gacgggcccg
     6241 cgacggcggc gagcgcgagc acgatgacca gcagcggcag ggcgagcagc acgtcggcgg
     6301 tgcgggcgat gaggccgtcg agccagcgcg gcgcgatcgc ggcgagcccg ccgatgagca
     6361 gcccgagccc gaccgtgatc gcggcggcgg tcagcccgac gagcagggac gtgcgggcgc
     6421 cgtagagcat ccgggtccac aggtcgcggc cgagcaggtc ggtgccgagc gggtggccgg
     6481 gcgagccggg cttcagcgac gtcgcggacg tgtcggtggc gaccgggtcc agcgaggtga
     6541 acagcggcgc gaggatcgcg agcagcgcca gcgcggcgag cacggcgacg gcggcgatca
     6601 gcgcggggcg ccggggccgc agccggacgg cgagcagccc gcgcacgcgg gccggcgcgg
     6661 aggcggtggc ggaggcggtg gcggtggcgg gggcgggggc gtcaggcggc atcggcacgt
     6721 cccgtccggg cgcgggggtc cagcgccgcg acgatcagct cggcggccag gttcgcggcg
     6781 atcacgatga ggccggtgac cagcacgatg gcgatgagca gcgggtagtc ctgggcgcgc
     6841 gccgcggtga tcgcctcgcg gcccatgccg ggccaggaga agatcacctc ggtggcgtag
     6901 acgccggcga tcagcgtccc gacgccgacg ccgagccggg cggtgaacgg cacgagcccg
     6961 ggccgcatca ggtgccgggc gacgacggtc cggcggggca gcccgcggac gcgggcgttc
     7021 tgcacgtgcg gcgcgtcccg cagccgtccg acgccgttct ccacgagccg cacgtacacg
     7081 ccgaagtggt ggccgaacgc gagcgcgcag gcgggcagcg ccaggtgcgc gagcagcccg
     7141 tacgcggtga cgggctcgcc ggggcggctg accccgccgg acggcatcag gtgcgtcgcc
     7201 gccgcgaacg cgtacagcag cagcagcgcg acgacgaacc cgggcatgcc gcccgtcacg
     7261 aacagcagga ggtcgatgcc gcgtcgcagc cacgcccgcc gggtgagcgc ggcgacgagc
     7321 ccgaccgcga gcgcggcggt gaagctcagc aggatcgcgg cggcggtgag cagcagcgtc
     7381 cacgggacgg tgtcgccgag cgtctcggtg acgggccgcc ccgacatgta ggaggtgccg
     7441 aggtcgccgc gcacggcgtg cgacgcccac cgccagtacc ggacgggcgg cgggtcgtcg
     7501 aggcccatct ccccgcgcag ctcggcgacg gcggccgggg acggcgggcg cccgcccgac
     7561 cgcgactcca gcacggacgc ggccgggtcg ccgggcgcgg cgtccaggag cccgaagcac
     7621 accgccgaca gggcggcgac gaccagcgcc gccgtcgcca gccggcggac cgcacgcagg
     7681 gccatctagt tgtagcgcca ggtctcggcg ttccagaaga acccgtagcc gtggtggccc
     7741 agcgtgcgct gcgcgggccc ggtgaggttc ttcgggacgg cgttgatcgt cttgaggtag
     7801 gagatccaca cgaacggcgg gtcgtcctgg agcgcctgct ggaacgcggt gtaggcggcc
     7861 ttccgcttgg cggggtcgag ggtggagcgg ccctcctcca gcgccttgtc ggcggccggg
     7921 ttgctgtagg agccgtagtt ggagccgccc ttggcgagcg cctgcgacgt ggcgaacggc
     7981 ccgtacaccg aggagtccgg gtcatagggg gtgccccagc cgaccaccat gccctgcagg
     8041 tcgccccagt gcttgcgcac ccagtcgcgc gggcgcgggc gcgggtcgac ctcgaagccc
     8101 tgctgcttga gctgcgtcgc ggacacgttg aggatcgcga cgcgcagcga gtcctcggcg
     8161 aaggtcgtca gctcgaactt caccgtcctg ccgttcttcg cccacagccc ctggccgttc
     8221 ttggcgtacc cggcgtcctt catgagcgac gccgtcttgg cggggtcgaa cgtgaagccg
     8281 ggggcggccg cgtacgggcc ggcgtccagc gggcccttcg ccggggagcc gtagccgagg
     8341 acgacgctct tggcgatggc gtcgcggtcg acggcgtggt tcatcgcctg ccggacccgg
     8401 cggtcggcga acaccgggtc cttcatgttg aacatgagcg cccggtagtc ggcggtcggg
     8461 tacacctcca gccggtgccc gccggccttg cccgcctgct gcggcgcgag gttcgcggcg
     8521 tcgacctcgc cgttgcgcag ctggatcagg cgggccgagt cgtccgggac gtacttgatg
     8581 acgaccttct tcaggccggg cttgccctcg tagtagccgt cgaacgcggt cagctcggcg
     8641 tactggccgt gcttgtaggt ggtgagggtg aacgggccgg tgcccacggg gtgctgcccg
     8701 aagccggggt cggtgagctt cttgccctgg agcaggtgct tgggcagcat gcccatcgac
     8761 accgcgtcga gcatcggcgc gaacggctcg tcgaggacga gcctgaccgt cgccgggtcg
     8821 ggcgtctcga ccgacttcac catcgtgaag ttgcgcgaca gcggcgagtc ggcgcccgcg
     8881 tcgcggacgg cctcgatggt gaacttcacg tcgtcggcgg tgaacggcct gccgtcctgc
     8941 caggtcgcgc cgggccgcag cgcgaacgtg tacgtcctgc cgtcgggcgc gatcgtccac
     9001 gacctcgcca gccccgggac gaccttgttg tccttgtcgt gcctggtcag gccgcggaag
     9061 acgagttcgg tcaccgggtc agtgtgctcg tcctggaggc ccgggttgaa ggtctccggc
     9121 tcgtccccga tcgcgtacgt gagcgacccg tccttcgtgc cggaggccgg tccgtccccc
     9181 tgcccgcacg cggacgccac cgaggccgcc atgacaacgg ccatcaccgc caaaaccgga
     9241 cgtttcacca tggcgggcat tattgcaaac tctatgcagt agcgagcaac tcgcatctac
     9301 ctcccggcga gcccggcccg ccggcgccgc cgccgcgccg gcccggaggc gggcgcccgg
     9361 gacccggctc cggccagcct ccggaccgcg cagcggatcc gcatttctgg cgcggtccat
     9421 ccttctttcc gcaacccttc gagccttccc aaaggtgaag tgagcgagcg gaatatcggc
     9481 ggacgtgcgg cccgcatccc atcctcagtc ggacaatccg gataaattcg gacagtagaa
     9541 ttgccttcgg tcgcgccgcc attgcccatc cgggccgggc cgatctccgc gccggcgccg
     9601 cccgctgggt cgtaaaaggg cccacgagct gccgcttcgc cggccgcccg gcctgatgcg
     9661 gacagaaact ggatcataac ttttttgttg agatcaaagt ttacgaaagg ccccggtcaa
     9721 gcccgccgca ggtcctcttg cggacagttg atcgcctctg ccgtcacacc ggtcacaccc
     9781 gtcacggcga ttaatgcgcc cggagaatat tccctactga accgatcggc ttgatttaga
     9841 ataatgcctc tggatttctc cgcgaaaccg tggttaccgt gttcccgttc gccgagaagt
     9901 ccccggccgg caccggaaga ggcggacccg atcaaggcgg cattcgatct ttgcgtgcgt
     9961 agggcggcac tctaaacgcg caatgagagc ggagatcctc atggtggatt tcaatttcag
    10021 tgtcttctcg gctgccccgg cggccgccga cgaggacacg gctctcaccg atctcctcgc
    10081 gacggcggtc gggcgggcgc ccgccgcgcg gcggtggcgg acgggccggg ccggcctgtg
    10141 gtgcaccgcc gtcccggacg gggcgccccg ccgcgggcag ggctggaaac tgcacgtcac
    10201 gggcactccc gcggcggcgc ccgagatcct cgagcgctgc ctggaggtgc tgctcggggc
    10261 cggctcggcg ttcaagttcg ccgccacgac cgactacgtc gcggccatga acgcgcgcaa
    10321 cacgccgcgc gggcattcgg gcaagttcat cacggtctat cccgaaagtg acgacgaggc
    10381 cgtccggctc gccgccgcgc tgcacgcggc gacggccggc cttccgggcc cgcgcatcct
    10441 ttccgaccgg ccctacgcgc cggacagcct cgtgcattac cgctacgggg ctttcaccga
    10501 ggaccggcgg ctcaccaatg acggattcta cgcgtggatg atcatcgacc cggacggcaa
    10561 tccggtcgag gatcggcgcc tcggccgcta cacccctccc ccctgggcca cctgcccctt
    10621 tcccgacaac ggcaggcgcg tcacccgcgc ggaaggtcgt tccggaaagg acattgtgat
    10681 cggcgggcgc ttcgcggtca agaacgcgat ccggcacacc aacaagggcg gcgtttaccg
    10741 cgccgtggac gtccgcaccg gcgacgcggt ggtgctcaag gaagcacggc cgcatgtcgc
    10801 cgccgatccg gaaggccgcg acacccgcga ccggctgcgc gcggaggcgc gcgcactcga
    10861 acgcattcgg caccgcggga tcgcgccccg gcccgccggc ctgttcaccg agagcgggca
    10921 cctgttcctc gcgcaggaga tgattccggg aacgccgctg cgggaatgga cgtccgattc
    10981 catccgcgac gccggctggg gcccgcacct cgctccggcg ctggagatgg cgcgccggct
    11041 ggccgacctg atgatcgagg cgcacgccac cgggctcgtc ctgcgcgact tcaaccccaa
    11101 caacgtcatg gtgcgcccgg acggcgctcc ggtcctgatc gacctcgagc tggccgtggt
    11161 ggcgggcgac ggcgaggaga cgccgctgcg cgcgggcacc cccgccttca gctcgccgga
    11221 gcagttcgag ggcgcgccgc cgcacgcgac ggccgactac tacagcctcg gcgcgaccct
    11281 ctgctacgtc ctcaccggcg ggccgccgta cttcatggag gagcgcccgc ggtcccggcc
    11341 gctgacgcag cggctcaccg aatggctcgc ggcccgcacc cagggcctcg acctgccgga
    11401 atccctgcgg gcggtgctcg tggagctgat ggcggacgac cccggacgcc gctgcacgcc
    11461 ggcaagggca cggtccgtcc tggcctcgat ctcctcgtcc cccgtccccg ctcagagccg
    11521 ggccgacgag gacgccggac cggacgagtg gctgcaggag gcgtgcgagc aggccgtcag
    11581 gggcatcacc gggcggctgc tcgcggccat ggagccggag tcggcgcagg cgctgtggcc
    11641 gatgtcctgc gtgcacggcg cgcccgaccc gtgctgcgtc cagcacggcg ccgcgggcgg
    11701 cctcggcgcg ctggtgcggt acatgcggca cacctccgac ccgcgcctgc cggacgcgtc
    11761 cgccaccgcg gcgcgctgga tgctggaccg cctgcgggac ggcgcccggc ggccgtccgg
    11821 cctctacttc gggacggccg gcgtcgcgtg ggcgctgctc gacgcgggcc tcgcgctcgg
    11881 cgacgacggc ctggccgagg aggccgccgc gatcgcggag gcgctgcccg tcaccgcccc
    11941 cggcccggac gtgacccacg gcaccgcggg catcggcatg accgccctgc acctgtgggc
    12001 caggaccggc cggaagccgt tcgccgagcg cgcgcaggcc gccgcggacg cgctggccgc
    12061 ctccgtcgag gagggcccgg acgggctcgt ctggcggacg cccgcccacg tggagtccaa
    12121 gctggcgggc aagtcgtact acgggttcgc gcacggcatc gcgggcgtcg ggtacttcct
    12181 gctcgcctgc gcggaggcga cgggccgcgc cgagcaccgg gagctggccg tccgggtcgg
    12241 ggagagcctg ctggacgcgg cggtcgtcac gccgcggtcg gcgatgtggg gcgccgggac
    12301 cggcgacccg cccaccgccc cctactggtg ccacggcgcg tccgggatcg ggacgttcct
    12361 cgtccggctg ggcgccgcca ccggcgacgc gcggttcgcg cgggcggccg acctgtccgc
    12421 ccgcgcggtg accgaccagt cgtggcgcgc ggtgctcggg cagtgccacg gcctggcggg
    12481 caacggcgac ttcctgctcg acatggccga cgtcaccggc gacgcccggc accgggccgc
    12541 cgcctggcgg ctcgcccgga tcatcatcgc gagccgcgcg caccgcgacg gccggatcgt
    12601 cctgcccgac gagcgcggcg acgtctcgat gagctggggc gaggggctga gcggggtgct
    12661 ggccttcctg gtccggctgc ggtacggcgg ggagcggctc tggatggccg acgccgcgtc
    12721 cgcgccgggt gcggccgagg acgcggtggc cgggacggcc gtgcgggggt ccgccccgtg
    12781 agcgccacag tgaacggaac ggtgaacggc accgcgggcg acgccgcgga ggcggcggtg
    12841 cccgccctgc cggggatccc gagccggttc gggctcgcgt tctccgccgg cggccggtgg
    12901 gcggcctgcc tgagcgccgt cgacgaccac gtgacgctgg agcggtggaa cctcgcccgc
    12961 gccgtgccgt cccggcgggt gttcggcggc gggaccgtcg cctcggggcc cggccgccgg
    13021 gagcccgtcg accggcacag ccgcccgctg ccgctggacg acggccgcct cctcgtggtg
    13081 cgcgccgagg tcgacgcgca cgggacgccc gccggccacg gcacggtggt cgcggcgcag
    13141 gccgggcacg gcggcacgac cgtcgggcgg tcgtgggcgg tcccgtcgat gctggccggg
    13201 tacgcgctgg cgagccctgg cgccccgcag accgtcgtcc tggtgaccgt gcaggacgag
    13261 caccggtcgc ggatctggga gctgtcgctc gcgaccggga cgctcgaacc ggtcatggag
    13321 atccccggcg cgctgtcggg cggcgtgtgg ctcgacgacg ggcgcacgct cgcgctcgac
    13381 caggcgaccg cggaccaccg cgccgacggg atcgccgtcg acctgcgcga acgctcgtgg
    13441 cggcgggtct ggtcggtggc ggcggcgacg gccgaccgga tcgtcgcctg cgaccgccgc
    13501 tcggggaccc tcgcggtgac caccggcctg cccggcgccc agtggaccgg cgccctgcgg
    13561 atcgggctgt ggacgcccgg cggcgggcgc gtccggttcc ccgccgcgct caaccggccc
    13621 gccggcggca tggtcccgct ggccttcgac gacaccggcg cgcacctgct ggtgagcgag
    13681 gtgtcgggcg cggtgtcccg gctcctggtg cacacccggg ccgacgaccg gctcgaaccg
    13741 gtggccgtcc cgcccgggct ggccggggcg cccgcctcgt ggacgggcga ccgcatccac
    13801 ctgcggttct cggcgccgca cctgccgccg acgctggcga cggcgcacac ggcggcggcc
    13861 catccgccgc tcgcgggctg ggcgccggtg cggcgggcgc ccgacgtcgc ggcggactgg
    13921 cgggccgccg acctggtcga gctgccgggc ccggcggggc cgatcgaggc gatcgtctac
    13981 ggcggcccgc gctggcgcga gcggcggcac ttggtgctgg cgctgcacgg cggcccgctg
    14041 tcggcgtggc ggttcgagtt cgacccgctt ttccagcacc tcgccgcggc cggcgtcgcg
    14101 gtggtggcgc ccaatcagcg cggcagtacc ggctacggcg agccgcacct gcgcgcggtc
    14161 atcggcgact ggggcggccc cgacctggac gacgtcgtcc atctggcgcg cggcatcgtc
    14221 cggccccggc gggacgccgg gctgccggag ccggtcgtgc tcggcggcag ctacggcgcg
    14281 ttcctcgcgc tgctggccgc ctgccacagc ccggacctgt ggtccggttg cgtggcgctg
    14341 gcaccgttca cctccgccga cggcctgtac cgcgacgcgc ccggccccgt ccgggaccgc
    14401 gtcgcccggc tcgaccgggt cggcggcgga acggacggag cgcgcgacgt cctgcgcagg
    14461 tgcgatgcgc tcacggcgcc gctgctgctg gcgcacggga cccgcgacga ggtcatcccc
    14521 gtcgcgcact cccgggcgct gcggcggcgc ctcctcgaac tcggcaggac cgaagggacc
    14581 ggcctcggct acatcgaggt cgacgacggg cacaccgccg tcgtccaggc atggtcccgg
    14641 gtcctccgga cggcggtggt ccgcttctgc ctcacggcgg agcggatctc ggcgacgacc
    14701 accgaaggga ggtgaaccga atggagaaca tcttcgaggg cgacctcgtg gcggagctgc
    14761 aggagctgcc cgagaccgac cccatcgaga tcgagggcgt tcagctcagc ggcacgtgcg
    14821 cgtgcgccgg cctgctgacc ctgctgaact ccgtctgcgt cggcatctcc tgcgcgtgat
    14881 gccggcaccc tccgcgggcc cgggcgcctg aggtgacccc cgtccgctga caccggtcac
    14941 ggatcggccg gaaggccggt ccgtgaccgg acccactttc cactgtaacc cgatgcccgc
    15001 cgagaaccca tgcccgccga gcgagaacgg agccgacgcg cgtgcccgag ccggagtccg
    15061 aagcgggggc gcccgcggcg ctgcgccggg agggccggcg gctgctgcgc gcggcggcgc
    15121 gccggttccg cgcgctgctg gccctgctcg cggccgccac ggtcgtgcgc gtcgcggcga
    15181 tgctggcgac cccggtcatg ctcggccggg cgatcgacgc ggtgcgctcc ggccacggcc
    15241 tcggcgccgc gatcgccggg ctcgcgttcg tcctgctcac cgccgcgctc gccgacgcgg
    15301 ccgaggagct cctcggcacc tactgcggca gccgcatcac cgcctggctc cggcaccgcc
    15361 tcgtcgggcg ggtcctggag ctcggcgtgc ccggccggcg ccgcttcccc gccggggacg
    15421 tgctgtcccg gctcaccgag agcgcgggcg ggccggccgc gttcccggcc ctgctgctgt
    15481 ccggcgcggc ggcgctggcg acgacggccg gcgcggtcgt cgcgctcgcc ctgatcgact
    15541 ggacgctcgc gctggtcttc gccctcgggg tgccgccggc cgtcctcgcg ctgcggatgt
    15601 tcgtcgccaa ggccggcgca cccttcgccg actaccagcg ccaccaggcg gagatcggca
    15661 cgcggctgct cgacgcccgg cagggcgccc ggaccatccg ggcctccggc accaccgccc
    15721 gcgaggtccg gcggatcctg cggccgctgc cgctgctcgg cgcggccggg cggctgacct
    15781 gggacgcgca ggggcaggtc ggctggcggc tgtcgctgct cgcgccgctg ctgcagatca
    15841 cggtcgtcgg cgccgccggg ttccggctcg cggccggtga cgtcacggcg ggcgagctcg
    15901 tcgccgcggc gtcctacacg gccatggcgg tcggcgcggc ggcgctgttc gacaccttcg
    15961 tcgcgctgct gaactgcgag gtcggcgcgg gacgcgtcgc ggaggtcctc gacgcggtcc
    16021 cggccgtccg gccgccggag cggccggtgc cgctgccgga cggtcccggc gcgctgcggc
    16081 tgcgcggggt caccgtccgg gtcgggggcc ggacggtgct cgaccgcctc gacctcgcgg
    16141 tgccgcccaa caccgccgtc gcggtcgtcg ggacgtccgg gtcgggcaag agcgtgctgg
    16201 tggcggcgat cgcgcggctc gtcgacccgg acgagggccg cgtcgagctc gacggcgtgg
    16261 acgtcgcgga cgtcgcgctc ccggagctgc ggcgcgccgt cgcgtacgcc ttcgagcgtc
    16321 ccgcgctgct cggcgcgacc gtgcacgaca tgatcgccta cgcgcgtccg ggcgccgcgc
    16381 gcgccgaggt gcggcgcgcc gcgcggacgg cggcggccga cgggttcgtc cgggcgctgc
    16441 ccgccgggta cgacaccccg ctggcggagg cgccgatgtc gggcggcgag ctgcagcggc
    16501 tcgggctggc ccgcgcggcg ctggcggacg cgcggctcct cgtcctcgac gacgccacca
    16561 gcagcctcga caccgcgacg gagatgcggg tgacgcgggc gctgcgggag gtcctcgcgg
    16621 gacgcaccag cctggtggtg gcgcgccgtc ccgcgacggc ggcccgcgcg gacctcgtcg
    16681 cctggctcga cgcgggccgg atccgcgcgc tcgcgccgca cgccgaactg tgggccgacc
    16741 cccggtaccg cgccgtgttc gccgccgagc ccggcgagcc aggcgacccg gtgccggccg
    16801 ccgccgcccc gggaccggcc gcgtgaccgc cgcacccgcc gcgtccgccg cagagcgcgc
    16861 cgccgtgccc gccgcgaagg ggcgcacggc cgcgcccgcc gcccggctgc tccgccgtca
    16921 cctgcgcggg cgggggcccg cgctgcgccg gctcgcgctg tggtcggcgg tcgagagcct
    16981 gccggcgttc gcgtccgggc tgctgctcgc ccatgccatc gacgacggct tcctggcccg
    17041 ccgcccgttc accgggctcg cctggctcgc cgccctcggc gccctccagg cggccggcgc
    17101 gctcggcacg cggcggatct acccgtggct cgccgccact gtcgagccgc tccgcgactc
    17161 gctcgtcggc gaggtcgtcg ccggggcgct gcgccgcacg gtcgaccggg ccgccgatcc
    17221 ctcgtcgggc ggcgccggcg ccgggatctc gcaggtcacc gagcaggcgg aggccgtccg
    17281 gatgctgctc gggacggcgc tgcgcaacgt ccggcagatg ctcgcggccg gcctcgccgc
    17341 gctgctcggg ctgacgctgc tcgccccact gcccgccctc accgccgccg tgtcggtggc
    17401 gctcgcgctc gggctgttcg cggcgctgct cggcgtgcag gtccgccgct accgcgcggt
    17461 cgtgcgggag gccgagcgca tcggcgagac ggcgacggag atcgtgcagg gcgtccggga
    17521 cgtggtggcg tgcgcggccg aaccgcgcgc cgcccggacc gtcggcgagg cgatcgacgc
    17581 gcaggccggg gcgctgcggt cgttcgcgcg gtcccggctc gtccggctgc cggtgctggc
    17641 gctcggggtg cacctgccgc tgctcgcgct gctcgccctg tcgccgcggc tcgtcgacga
    17701 ccaccggctc accaccgggc aggtcgcggg cggggtgagc tacctggtca ccgggctgca
    17761 gccggcgatg gtgctgctgg tcgacgcggg cgggacgctg ctgctcagcc tggccgtggt
    17821 cctcggccgg ctcgccgagg tctgcgccgg gccggacgcg gcgccgcgcc ccgccgcgcc
    17881 ggtcgccgcc acgtcctacg gcctggaggc cgagcacgtg acgttcgcct actccgcctc
    17941 cgccgcgccc gtcctcgccg acctgtccct gcacatcccc gagggcacgc acctggccgt
    18001 ggtcgggccg agcgggacgg gcaagtcgac gctcgccgac gtcctcaccg gcctcgcccg
    18061 cccccagcgg ggaagcgtca cgctcggcaa ggtggcgctg gccgacctcg gcgaggagcg
    18121 gctgcgggcg gccgtcgcgc tcgtcccgca ggagagctac gtcttcgccg ggacgctccg
    18181 ggagaacctc gcctacctgc gcccggacgc ctcggacgcc gatctcgacg cggccgtcga
    18241 cgcgatcggg ctgcgcgcga ccgtggaccg gctcggcggc tacgacgccg ccgtcccgcc
    18301 cggcggcggc accctgtcgc agggcgagcg ccagctcgtc acgctcgtcc gcgcgcacgt
    18361 gtccggcgcg cccgtcacga tcctggacga ggcgacctgc cacctgcacc ccgccgcgga
    18421 ggcccgcgcg gaacgggcgc tggccgcgcg cggcggcacg ctcatcgtca tcgcgcaccg
    18481 catcagctcc gcccagcgcg cccagcgcgt cctcctcctg gacggctccg ccccgctcct
    18541 cggcacccac gacgcgctgc tcgccctcag ccccctttac gccgagctcg tcggccactg
    18601 gcggacctga ccgcccggat ggtcctggac cgatcctttg ccaacggcgg agggtcggcg
    18661 gcggggcccg gcggcgccgc gaccgtacgg tttctgccag tctcgacatc gctggggagg
    18721 ccgcgtgccg accgccgcac ccgaacgccg gcccgccggt ctcgcgcgcc tgggcgcgtt
    18781 ctgcgcccgc cacccgtggt gggtgctcgc cgcgtggatc gtgctgctgg tggccgcgct
    18841 cggcggccgc aaggccgtcg gccccacgtt cagcgaccag gtcagcctgc cgggcaccca
    18901 gtccgacacc ggcaagatcc tgctcaccgc gtccgacccc gcggcgaacc ggcccaacgg
    18961 ccaggtcgtg ttccacgtcg ccgccggcac cgtgtcggcg caccagcagg cggtcgacca
    19021 gagcctcgga aacctgaagg cgctgccgca cgtcaccggc gtcccgaccc cgctgaccag
    19081 caccgacggc cggacggtgt ccgccaccgt gtcgttcgac gagcagctcg cacagctcgg
    19141 ccacggctac accgcacggc tcgacgacgc caccgagccg gcgcgcgccg ccggcgtcgg
    19201 cgtcggctac ggcggggact tcacccagat cgtccgcccg cccgccaacg acctgctgag
    19261 cgagctcgtc ggcatcggcg ccgcgctcgt cgtcctgctc gccgcgttcg gcagcgtcgg
    19321 cgcggccgtg accccgctga tcaccgcgct cgtcgcggtg gccgtgggga cgggcgtggt
    19381 cggcatcgtc gcgggcgtca tcacgttcgc gaccgccgcg ccgaccctcg ccaccatgct
    19441 cggtctcggc gtcggcatcg actacgcgct gttcctgacc acccggttcc ggcaggacct
    19501 catcgagggc cgctcgcccg tcgacgccgc gggccgcgcc gcgggcacca gcgggcacgc
    19561 catcgccgtc gccgcgatca ccgtcgtcgt ggcgctgctc agcctctacg ccagcggcct
    19621 gtcgttcatc ggcaggctcg ggctggccgc gaccatcgcc gtgctgatca gcgccgccgc
    19681 ggcgctgacc ctcgtccccg ccgcgctcgg gctggcgggc cggagcatcg accggctcgc
    19741 cgtccggcgg cccgtcgccg agacctccag cgcccgcgac tcctggcacc ggtacgcggg
    19801 gctgatcgag cgccaccggt ggacgtccct cgccgccggg ctcgtcctgc ccgtcgtgtg
    19861 cgcggtgccg gtgttctcga tgcggctcgg gcacgtcgac gcgggcgcgg acccgtccgg
    19921 cagcaccacc cgcaacgcct acgactgggt cgccggcgcc accggccccg gcttcgggcc
    19981 gggcgcgaac gggccgttca cggtggtcac cgacgtccgg cacgcgaccg tccccgccgg
    20041 ccagatcagc agcgacctct cgcacgcgct gcagagcacg cacggggtcg cgagcgccac
    20101 gcagccgcag ccgagcccgg acggcgcgct cctcgtctcc accgtcacgc ccaccaccgg
    20161 gccgcagacc gcgtccacgt ccgatctgtt ccgcaccctg accgatgaca cgctgcccgg
    20221 cgcgctgcac ggcaccggcg cgaaggccta cctcaccggc accaccgccg gccggctcga
    20281 ctttcgcgac accgtcgccc gccgcctgcc gatcatcatc gggatcgtcc tggtcctggc
    20341 gtacctcctg ctcatgtcgg tgttccgcag cctggtgatc ccgctcaagg ccgtcctgct
    20401 caacctgctc accaccgccg cgtcctgggg cgcgctcgtc gcggtgttcc agtggggctg
    20461 gggcgacgcc gtgctgggcc tgcccgaggg cgtgccgatc gagtcgtacg tgccgatgat
    20521 gatgttcgcg atcgtcttcg gcctgtccat ggactacgag atcttcctgc tctcccggat
    20581 ggccgccgtc tgggacggga cgcacgacaa cacccgcgcg gtggccggcg gcctcgccgt
    20641 caccggccgg gtcgtctcca gcgccgcgct gatcatgacg gtggtgttcc tgtccttcac
    20701 cgcctcgccg accgtcgtgg tgaagatgct ggcgctgggc ctggccttca gcgtcatcct
    20761 cgacgccacc atcgtccgcc tggtgctggt cccgtcgctc atgttcctca tgggctcctc
    20821 caactggtgg ctcccccgcc gcctagcccg cacgctcccc cacctccacg cctagtggcg
    20881 cggggggcgg cttcggcgtc gtcgtggccc aggcttcggc gagcaggtcg taggagcgga
    20941 cgcggtcggc gtggtcgtgg gtgatcgtcg tgatgagcag ctcgtcggcg ccggtgacgc
    21001 gctgcagggt ggcgaggccg tccgcgacgg tgccgggcgc ccccgtgaac tgggtgtcga
    21061 cgcggtcggc gaccaggtcg aggtcctccg gacgccagtc gtgggcggcg gcctcggccg
    21121 gggtggggaa cgggatcgcg gcgagccggg accggatgct gtgcacccac agcgcgtacg
    21181 gggacgcgag gtcgcgggcc tccgcgtcgg tcggcgcgac gacgacgtcg gcggacacga
    21241 tgacgtacgg ctcgtccagc acgtccgacg gccggaacgc cgcccggtac gcctcgacgg
    21301 cctccagcac gttggacggg ctgacgtggt agttcgccgc gaacggcagc ccgcgcgccc
    21361 ccgcgacgcg ggcgctctgc ccgccgctgc tgccgaggat ccacaggtcg agcgcggcgc
    21421 cttcgccggg gttggcgtgc gcctcgtggc cgtccttggc gtaggtgccg gcgatgagcg
    21481 cggcgatgtc gtcgacggcg tcggcgaagt cgggggactc ggcgccgggc tgctggagga
    21541 gggcgccgtg caggccgaac gcggcggacg cggcgagccg cgtgacgtcg aacggcgccg
    21601 ggatgagcag gccgtccacg agttcggcct cccgggcggg tgcgggcggc ggggtgcggc
    21661 gggacgcctc ggcgcggcgc tgcccggagc ggccgggccg aggtcgatcc ggccggggtg
    21721 cagcgcgtcg atcgtgccga actgctcgac gatggacagc ggcgtccagt gcccggtctg
    21781 gacggcgccg gagccgacgc ggatccggga cgtggccgcc gcgaccgcct cgatgaggat
    21841 ctgcggcgcg gcgctcgcga cgccgggcgc gaggtggtgc tcggcgagcc agtagcggcg
    21901 gtagccggcg gcctcggtgc ggcgggcgag gtcgagggtg ttgcggagcg cgtcgcgcgc
    21961 ggtgccgccg gcggagatgg gggcgaggtc gaggacggac agcggggtca cgggcgcctc
    22021 cctgcggggg tcgggaacgg ccggctcggt atctccgcgc gcaggacggg cgcgacgtcg
    22081 ctctggaaca gctccaggga cgcgcggtgc aggtcctcgg ggatcccgtc ggggtcggcc
    22141 tggacgtgca tgacctcgtg cccgagccgg tcgtggtagc ggtggacctt gtcgatgatc
    22201 tgctgggggc tgccgacgag cgcggagccg cgttcgacgg cgtcctcgac ggagtcgaag
    22261 acgggtgtga cgccgttgcg gcggaacagt tcctgcctcg cctcgaacac cggccggtac
    22321 acctcgacgg cgtcctggga cttcggggcg acgtagaggc cggcggttcc ggctccgacg
    22381 agggcgtcgg aggggtcgtg gccgtggtgc gcccaccgct cccggtagta ggagaccagc
    22441 tcggcgtacg gctcgacggg gttggtgacg ttcgcggaga acagcgggtc gccgtagcgg
    22501 gcggccagct cgacggactc cctgctggtg gcgctgccgt gccagacgcg gacgggccgc
    22561 tggagcgggc gcggcagcac ctcggcgccg tcgagcggcg ggcggtgctt gccccaccag
    22621 gtgacgctgt cctcgcgcca gagccggcgg aacagctcgt agccctcgcg gttgcggtcc
    22681 cactggtcct cggcggtgac gtcgaacagc gcggcctgcg cggtgccgtt gcccttgccg
    22741 atgatcagtt cgaggcgtcc gccggacagg tggtcgaggg t
//
